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Citations to this article

Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.
S Kagami, … , D E Miller, N A Noble
S Kagami, … , D E Miller, N A Noble
Published June 1, 1994
Citation Information: J Clin Invest. 1994;93(6):2431-2437. https://doi.org/10.1172/JCI117251.
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Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.

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Abstract

Angiotensin II (Ang II) has been implicated in the development of progressive glomerulosclerosis, but the precise mechanism of this effect remains unclear. In an experimental model, we have shown previously that TGF-beta plays a key role in glomerulosclerosis by stimulating extracellular matrix protein synthesis, increasing matrix protein receptors, and altering protease/protease-inhibitor balance, thereby inhibiting matrix degradation. We hypothesized that Ang II contributes to glomerulosclerosis through induction of TGF-beta. Ang II treatment of rat mesangial cells in culture increased TGF-beta and matrix components biglycan, fibronectin, and collagen type I at both the mRNA and protein levels in a time- and dose-dependent manner. Saralasin, a competitive inhibitor of Ang II, prevented the stimulation. Ang II also promoted conversion of latent TGF-beta to the biologically active form. Coincubation of mesangial cells with Ang II and neutralizing antibody to TGF-beta blocked the Ang II-induced increases in matrix protein expression. Continuous in vivo administration of Ang II to normal rats for 7 d resulted in 70% increases in glomerular mRNA for both TGF-beta and collagen type I. These results indicate that Ang II induces mesangial cell synthesis of matrix proteins and show that these effects are mediated by Ang II induction of TGF-beta expression. This mechanism may well contribute to glomerulosclerosis in vivo.

Authors

S Kagami, W A Border, D E Miller, N A Noble

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P Trindade, B Hampton, AC Manhães, AE Medina
Journal of Neurochemistry 2016
Glomerular Function and Structure in Living Donors: Lessons from Single Nephron Studies
CR Lenihan, BD Myers, JC Tan
Current Transplantation Reports 2016
The cellular and signalling alterations conducted by TGF-β contributing to renal fibrosis
G Vega, S Alarcón, RS Martín
Cytokine 2016
New molecular insights in diabetic nephropathy
IA Checheriţă, G Manda, ME Hinescu, I Peride, A Niculae, Ş Bîlha, A Grămăticu, L Voroneanu, A Covic
International Urology and Nephrology 2016
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee
Endocrinology: Adult and Pediatric 2016
Serum levels of TGF-β1 in patients of diabetic peripheral neuropathy and its correlation with nerve conduction velocity in type 2 diabetes mellitus
G Hussain, SA Rizvi, S Singhal, M Zubair, J Ahmad
Diabetes and Metabolic Syndrome: Clinical Research and Reviews 2016
Sodium-Glucose Linked Cotransporter-2 Inhibition Does Not Attenuate Disease Progression in the Rat Remnant Kidney Model of Chronic Kidney Disease
Y Zhang, K Thai, DM Kepecs, RE Gilbert, JC Dussaule
PloS one 2016
An additive effect of eplerenone to ACE inhibitor on slowing the progression of diabetic nephropathy in the db/db mice
Guangyu Zhou, Ulrika Johansson, Xiao-Rong Peng, Krister Bamberg, Yufeng Huang
American journal of translational research 2016
Role of the intrarenal renin–angiotensin system in the progression of renal disease
M Urushihara, S Kagami
Pediatric Nephrology 2016
Specific MAPK inhibitors prevent hyperglycemia-induced renal diseases in type 1 diabetic mouse model
Z Hong, Z Hong, D Wu, H Nie
Molecular and Cellular Biochemistry 2016
Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension
N Muñoz-Durango, C Fuentes, A Castillo, L González-Gómez, A Vecchiola, C Fardella, A Kalergis
International journal of molecular sciences 2016
Renal functional responses in diabetic nephropathy following chronic bilateral renal denervation
Y Yao, G Davis, JC Harrison, RJ Walker, IA Sammut
Autonomic Neuroscience 2016
Role of Angiotensin-(1-7) on Renal Hypertrophy in Streptozotocin-Induced Diabetes Mellitus
D Amato, AR Núñez-Ortiz, JC Benítez-Flores, D Segura-Cobos, P López-Sánchez, B Vázquez-Cruz
Pharmacology & Pharmacy 2016
Urinary Angiotensinogen Could Be a Prognostic Marker of the Renoprotection of Olmesartan in Metabolic Syndrome Patients
T Mizushige, H Kobori, H Hitomi, Y Nishijima, F Tomoda, S Morimoto, M Kohno, A Nishiyama
International journal of molecular sciences 2016
Sprue-Like Enteropathy Associated With Oxcarbazepine
PL González-Cordero, N Fernandez-Gonzalez, J Molina-Infante
The American Journal of Gastroenterology 2016
Endocrinology
C Napier, SH Pearce
Endocrinology 2016
Apelin-13 protects against myocardial infarction-induced myocardial fibrosis
X Zhang, W Hu, F Feng, J Xu, F Wu
Molecular medicine reports 2016
Involvement of the renin–angiotensin system in the development of nephrogenic systemic fibrosis-like lesions in the RenTag mouse model
S Sexton, R Tulowitzki, CA Jones, S Shah, G Hajduczok, KW Gross, M Panesar
Clinical and Experimental Nephrology 2015
Renin-angiotensin system blockade: Its contribution and controversy
A Miyajima, T Kosaka, E Kikuchi, M Oya
International Journal of Urology 2015
Histopathology of aortic complications in bicuspid aortic valve versus Marfan syndrome: relevance for therapy?
N Grewal, R Franken, BJ Mulder, MJ Goumans, JH Lindeman, MR Jongbloed, MC DeRuiter, RJ Klautz, AJ Bogers, RE Poelmann, AC Groot
Heart and Vessels 2015
Gastrointestinal Disorder Associated with Olmesartan Mimics Autoimmune Enteropathy
S Scialom, G Malamut, B Meresse, N Guegan, N Brousse, V Verkarre, C Derrieux, E Macintyre, P Seksik, G Savoye, G Cadiot, L Vuitton, L Marthey, F Carbonnel, N Cerf-Bensussan, C Cellier, AP Sampson
PloS one 2015
Urinary Angiotensinogen Could Be a Prognostic Marker of Renoprotective Effects of Alogliptin in Patients with Type 2 Diabetes
T Mizushige, H Kobori, Y Nishijima, Y Yano, K Sakata, M Hayakawa, A Nishiyama
Journal of Diabetes Research 2015
Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin
N Bertoncello, RP Moreira, DY Arita, DS Aragão, IK Watanabe, PS Dantas, R Santos, R Mattar-Rosa, R Yokota, TS Cunha, DE Casarini
Journal of Diabetes Research 2015
Angiotensin II Levels in Gingival Tissues from Healthy Individuals, Patients with Nifedipine Induced Gingival Overgrowth and Non Responders on Nifedipine
A Balaji
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH 2015
Role of upstream stimulatory factor 2 in diabetic nephropathy
S Wang
Frontiers in Biology 2015
Clinical-Pathological Conference Series from the Medical University of Graz: Case No 156: 82-year-old woman with chronic diarrhea and weight loss of 20 kilograms
E Fabian, D Schiller, H Wenzl, C Lackner, J Donnerer, A Ziachehabi, R Silye, R Schöfl, GJ Krejs
Wiener klinische Wochenschrift 2015
Olmesartan-induced enteropathy: Letters to the Editor
N Heerasing, C Hair, S Wallace
Internal Medicine Journal 2015
Add-on Protective Effect of Pentoxifylline in Advanced Chronic Kidney Disease Treated with Renin-Angiotensin-Aldosterone System Blockade - A Nationwide Database Analysis
KL Kuo, SC Hung, JS Liu, YK Chang, CC Hsu, DC Tarng
Scientific Reports 2015
Follistatin-like 3 suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose
Xiaohong Wang, Liyin Shi, Zhe Han, Baoshan Liu
International journal of clinical and experimental medicine 2015
Pediatric Nephrology
ED Avner, WE Harmon, P Niaudet, N Yoshikawa, F Emma, S Goldstein
Pediatric Nephrology 2015
Extracellular matrix-induced Hic-5 expression in glomerular mesangial cells leads to a prosclerotic phenotype independent of TGF-β
N Hornigold, A Mooney
The FASEB Journal 2015
Identification of new cases of severe enteropathy has recently increased the spectrum of intestinal non-celiac villous atrophy
G Malamut, N Cerf-Bensussan, C Cellier
Expert Review of Gastroenterology & Hepatology 2015
Central role of IL-17/Th17 immune responses and the gut microbiota in the pathogenesis of intestinal fibrosis:
S Ray, CD Salvo, TT Pizarro
Current Opinion in Gastroenterology 2014
Cardiac valve cells and their microenvironment—insights from in vitro studies
H Wang, LA Leinwand, KS Anseth
Nature Reviews Cardiology 2014
Targeting reduction of proteinuria in glomerulonephritis: Maximizing the antifibrotic effect of valsartan by protecting podocytes
C Gu, G Zhou, NA Noble, WA Border, AK Cheung, Y Huang
Journal of Renin-Angiotensin-Aldosterone System 2014
Hypoxia and the extracellular matrix: drivers of tumour metastasis
DM Gilkes, GL Semenza, D Wirtz
Nature Reviews Cancer 2014
Ghrelin Protects against Renal Damages Induced by Angiotensin-II via an Antioxidative Stress Mechanism in Mice
K Fujimura, S Wakino, H Minakuchi, K Hasegawa, K Hosoya, M Komatsu, Y Kaneko, K Shinozuka, N Washida, T Kanda, H Tokuyama, K Hayashi, H Itoh
PloS one 2014
Signaling Pathways Involved in Renal Oxidative Injury: Role of the Vasoactive Peptides and the Renal Dopaminergic System
NL Mikusic, MC Kravetz, NM Kouyoumdzian, SL Penna, MI Rosón, BE Fernández, MR Choi
Journal of Signal Transduction 2014
Olmesartan attenuates tacrolimus-induced biochemical and ultrastructural changes in rat kidney tissue
NO Al-Harbi, F Imam, MM Al-Harbi, M Iqbal, A Nadeem, MM Sayed-Ahmed, AD Alabidy, AF Almukhallafi
BioMed Research International 2014
Drug-induced injury in the gastrointestinal tract
NC Panarelli
Seminars in Diagnostic Pathology 2014
The comparative effects of perindopril and catechin on mesangial matrix and podocytes in the streptozotocin induced diabetic rats
SP Ertürküner, M Başar, M Tunçdemir, İ Seçkin
Pharmacological Reports 2014
Renoprotective Effects of Direct Renin Inhibition in Glomerulonephritis:
K Miyata, R Satou, D Inui, A Katsurada, D Seth, A Davis, M Urushihara, H Kobori, KD Mitchell, LG Navar
The American Journal of the Medical Sciences 2014
Changes in urinary angiotensinogen posttreatment in pediatric IgA nephropathy patients
M Urushihara, T Nagai, Y Kinoshita, S Nishiyama, K Suga, N Ozaki, A Jamba, S Kondo, H Kobori, S Kagami
Pediatric Nephrology 2014
Angiotensin II: immunohistochemical study in Sardinian pterygium
P Demurtas, M Corrias, I Zucca, C Maxia, F Piras, P Sirigu, MT Perra
European Journal of Histochemistry : EJH 2014
Diabetes mellitus, a complex and heterogeneous disease, and the role of insulin resistance as a determinant of diabetic kidney disease
J Karalliedde, L Gnudi
Nephrology Dialysis Transplantation 2014
A new saikogenin from the roots of Bupleurum bicaule
N XU, YN SHI, X ZHONG, Y CAO, L WANG, TZ JIA
Chinese Journal of Natural Medicines 2014
Renal renin-angiotensin system —What supports and breaks the circle of life—
S Kagami
Nihon Shoni Jinzobyo Gakkai Zasshi 2014
Pharmacologic Targets and Peritoneal Membrane Remodeling
K Farhat, AW Stavenuiter, RH Beelen, PM Wee
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2014
Regulator of G protein signaling 2 (RGS2) deficiency accelerates the progression of kidney fibrosis
HS Jang, JI Kim, M Noh, MH Rhee, KM Park
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2014
Angiotensin II stimulates fibronectin protein synthesis via a G  /arachidonic acid-dependent pathway
LD Alexander, Y Ding, S Alagarsamy, X Cui
American journal of physiology. Renal physiology 2014
Textbook of Organ Transplantation
J Stehlik, MS Kiernan, D Budge, MR Johnson
Textbook of Organ Transplantation 2014
The atypical chemokine receptor CCX-CKR regulates metastasis of mammary carcinoma via an effect on EMT
Y Harata-Lee, ME Turvey, JA Brazzatti, CE Gregor, MP Brown, MJ Smyth, I Comerford, SR McColl
Immunology and Cell Biology 2014
Ghrelin Protects against Renal Damages Induced by Angiotensin-II via an Antioxidative Stress Mechanism in Mice
K Fujimura, S Wakino, H Minakuchi, K Hasegawa, K Hosoya, M Komatsu, Y Kaneko, K Shinozuka, N Washida, T Kanda, H Tokuyama, K Hayashi, H Itoh, MC Vinci
PloS one 2014
Signaling Mechanism Underlying the Promotion of Keratinocyte Migration by Angiotensin II
H Sakai, K Matsuura, Y Tanaka, T Honda, T Nishida, M Inui
Molecular pharmacology 2014
Vascular Complications of Diabetes: Mechanisms of Injury and Protective Factors
C Rask-Madsen, GL King
Cell Metabolism 2013
Angiotensin II Type 1 Receptor Antagonist Attenuates Lacrimal Gland, Lung, and Liver Fibrosis in a Murine Model of Chronic Graft-Versus-Host Disease
S Yaguchi, Y Ogawa, S Shimmura, T Kawakita, S Hatou, S Satofuka, S Nakamura, T Imada, H Miyashita, S Yoshida, T Yaguchi, Y Ozawa, T Mori, S Okamoto, Y Kawakami, S Ishida, K Tsubota, PC Yang
PloS one 2013
Prevention of TGFβ induction attenuates angII-stimulated vascular biglycan and atherosclerosis in Ldlr-/- mice
T Tang, PG Wilson, JC Thompson, C Nelson, MH Yoder, LR Tannock
Journal of lipid research 2013
Beneficial Effects of the Activation of the Angiotensin-(1–7) Mas Receptor in a Murine Model of Adriamycin-Induced Nephropathy
KD Silveira, LC Barroso, AT Vieira, D Cisalpino, CX Lima, M Bader, RM Arantes, RA Santos, AC Simões-e-Silva, MM Teixeira, JC Dussaule
PloS one 2013
The role of urinary TGF-β1, TNF-α, IL-6 and microalbuminuria for monitoring therapy in posterior urethral valves
A Mandelia, M Bajpai, S Agarwala, AK Gupta, R Kumar, A Ali
Pediatric Nephrology 2013
Seldin and Giebisch's The Kidney
CJ Cooper, LD Dworkin, WL Henrich
Seldin and Giebisch's The Kidney 2013
Molecular mechanisms in the pathogenesis of diabetic nephropathy: An update
MK Arora, UK Singh
Vascular Pharmacology 2013
Cross talk between toll-like receptor-4 signaling and angiotensin-II in liver fibrosis development in the rat model of non-alcoholic steatohepatitis: Innate immunity in the liver fibrosis
Y Shirai, H Yoshiji, R Noguchi, K Kaji, Y Aihara, A Douhara, K Moriya, T Namisaki, H Kawaratani, H Fukui
Journal of Gastroenterology and Hepatology 2013
Plasma renin activity: An early marker of progressive renal disease in posterior urethral valves
M Bajpai, A Singh
Journal of Indian Association of Pediatric Surgeons 2013
Renoprotective effects of telmisartan after unilateral renal ablation in rats
T Matsuo, Y Miyata, Y Sagara, Y Higami, S Tobu, M Matsuo, M Noguchi, I Shimokawa, H Kanetake, H Sakai
International journal of nephrology and renovascular disease 2013
Therapeutic potential of targeting the renin angiotensin system in portal hypertension
CB Herath, JA Grace, PW Angus
World journal of gastrointestinal pathophysiology 2013
Losartan reverses permissive epigenetic changes in renal glomeruli of diabetic db/db mice
MA Reddy, P Sumanth, L Lanting, H Yuan, M Wang, D Mar, CE Alpers, K Bomsztyk, R Natarajan
Kidney international. Supplement 2013
The effect of RAAS blockade on the progression of diabetic nephropathy
SS Roscioni, HJ Heerspink, D Zeeuw
Nature Reviews Nephrology 2013
Time-course morphological and functional disorders of the kidney induced by long-term high-fat diet intake in female rats
CS Pinhal, A Lopes, DB Torres, SL Felisbino, JA Gontijo, PA Boer
Nephrology Dialysis Transplantation 2013
Prophylactic Add-on Antiplatelet Therapy in Chronic Kidney Disease With Type 2 Diabetes Mellitus: Comparison Between Clopidogrel and Low-dose Aspirin
A Dash, R Maiti, TK Bandakkanavar, A Bhaskar, J Prakash, BL Pandey
International journal of preventive medicine 2013
Prevention of TGFβ induction attenuates angII-stimulated vascular biglycan and atherosclerosis in Ldlr−/− mice1[S]
T Tang, PG Wilson, JC Thompson, C Nelson, MH Yoder, LR Tannock
Journal of lipid research 2013
Pathogenesis and Novel Treatment from the Mouse Model of Type 2 Diabetic Nephropathy
M Furukawa, T Gohda, M Tanimoto, Y Tomino
The Scientific World JOURNAL 2013
Prevention of TGFβ induction attenuates angII-stimulated vascular biglycan and atherosclerosis in Ldlr−/− mice
T Tang, PG Wilson, JC Thompson, C Nelson, MH Yoder, LR Tannock
Journal of lipid research 2013
Brazilian embauba ( Cecropia pachystachya ) extract reduces renal lesions in 5/6 nephrectomized rats
CC Maquiaveli, ER da Silva, HD Francescato, RS Costa, CG Silva, DE Casarini, FA Ronchi, TM Coimbra
Journal of Renin-Angiotensin-Aldosterone System 2013
The role of oxidative stress in renal injury induced in rats by losartan exposure during lactation
EC Marin, HD Francescato, RS Costa, CG da Silva, TM Coimbra
Journal of Renin-Angiotensin-Aldosterone System 2013
The effect of RAAS blockade on the progression of diabetic nephropathy
SS Roscioni, HJ Heerspink, D de Zeeuw
Nature Reviews Nephrology 2013
Transforming Growth Factor Beta, Bioenergetics and Mitochondria in Renal Disease
C Gabriella, D Ilse, B Erwin
Seminars in Nephrology 2012
Biological approaches to improve skeletal muscle healing after injury and disease
B Gharaibeh, Y Chun-Lansinger, T Hagen, SJ Ingham, V Wright, F Fu, J Huard
Birth Defects Research Part C Embryo Today Reviews 2012
Brenner and Rector's The Kidney
C Brugnara, KU Eckardt
Brenner and Rector's The Kidney 2012
Update on new aspects of the renin–angiotensin system in liver disease: clinical implications and new therapeutic options
JA Grace, CB Herath, KY Mak, LM Burrell, PW Angus
Clinical Science 2012
Severe Spruelike Enteropathy Associated With Olmesartan
A Rubio-Tapia, ML Herman, JF Ludvigsson, DG Kelly, TF Mangan, TT Wu, JA Murray
Mayo Clinic Proceedings 2012
Muscle
ML Martin, SL Belmonte, R Ram, FA Kamal, BC Blaxall
Muscle 2012
Garlic (Allium sativum) down-regulates the expression of angiotensin II AT1 receptor in adrenal and renal tissues of streptozotocin-induced diabetic rats
MH Mansour, K Al-Qattan, M Thomson, M Ali
Inflammopharmacology 2012
Captopril avoids hypertension, the increase in plasma angiotensin II but increases angiotensin 1-7 and angiotensin II-induced perfusion pressure in isolated kidney in SHR
P Castro-Moreno, JP Pardo, R Hernández-Muñoz, JJ López-Guerrero, LD Valle-Mondragón, G Pastelín-Hernández, M Ibarra-Barajas, R Villalobos-Molina
Autonomic and Autacoid Pharmacology 2012
Renoprotective Effects of Sildenafil in DOCA-Salt Hypertensive Rats
EH Bae, IJ Kim, SY Joo, EY Kim, CS Kim, JS Choi, SK Ma, SH Kim, JU Lee, SW Kim
Kidney and Blood Pressure Research 2012
Nop-7-associated 2 (NSA2), a candidate gene for diabetic nephropathy, is involved in the TGFβ1 pathway
R Shahni, A Czajka, BS Mankoo, AK Guvenel, A King, AN Malik
The International Journal of Biochemistry & Cell Biology 2012
Protective Effects of Quercetin on Streptozotocin-induced Diabetic Nephropathy in Rats: PROTECTIVE EFFECTS OF QUERCETIN ON DIABETIC NEPHROPATHY
H Hao, Q Lu, D Tang, Z Shao, X Yin, J Mou, Q Du
Phytotherapy Research 2012
Organ fibrosis inhibited by blocking transforming growth factor-β signaling via peroxisome proliferator-activated receptor γ agonists
YL Deng, XZ Xiong, NS Cheng
Hepatobiliary & Pancreatic Diseases International 2012
JAK-STAT and the renin-angiotensin system: The role of the JAK-STAT pathway in blood pressure and intrarenal renin-angiotensin system regulation
R Satou, RA Gonzalez-Villalobos
JAK-STAT 2012
Effects of Angiotensin Converting Enzyme Inhibitors on Liver Fibrosis in HIV and Hepatitis C Coinfection
LJ Reese, DS Tider, AC Stivala, DA Fishbein
AIDS Research and Treatment 2012
Role of the Transcription Factor Erythroblastosis Virus E26 Oncogen Homolog-1 (ETS-1) as Mediator of the Renal Proinflammatory and Profibrotic Effects of Angiotensin II
W Feng, P Chumley, P Hua, G Rezonzew, D Jaimes, MW Duckworth, D Xing, EA Jaimes
Hypertension 2012
The transcription factor ETS-1 regulates angiotensin II-stimulated fibronectin production in mesangial cells
P Hua, W Feng, G Rezonzew, P Chumley, EA Jaimes
American journal of physiology. Renal physiology 2012
Smoking in diabetic nephropathy: sparks in the fuel tank?
VA Chakkarwar
World journal of diabetes 2012
The periprosthetic capsule and connective tissue diseases: a piece in the puzzle of autoimmune/autoinflammatory syndrome induced by adjuvants
F Bassetto, C Scarpa, V Vindigni, A Doria
Experimental biology and medicine (Maywood, N.J.) 2012
Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in a murine model
Megan Podowski, Carla Calvi, Shana Metzger, Kaori Misono, Hataya Poonyagariyagorn, Armando Lopez, Therese Ku, Thomas Lauer, Sharon McGrath-Morrow, Alan Berger, Christopher Cheadle, Rubin Tuder, Harry C. Dietz, III, Wayne Mitzner, Robert Wise, Enid Neptune
Journal of Clinical Investigation 2011
Activation of Src mediates PDGF-induced Smad1 phosphorylation and contributes to the progression of glomerulosclerosis in glomerulonephritis
A Mima, H Abe, K Nagai, H Arai, T Matsubara, M Araki, K Torikoshi, T Tominaga, N Iehara, A Fukatsu, T Kita, T Doi
PloS one 2011
Impaired Vascular Contractility and Aortic Wall Degeneration in Fibulin-4 Deficient Mice: Effect of Angiotensin II Type 1 (AT(1)) Receptor Blockade
E Moltzer, L Riet, SM Swagemakers, PM van Heijningen, M Vermeij, R Veghel, AM Bouhuizen, JH van Esch, S Lankhorst, NW Ramnath, MC de Waard, DJ Duncker, PJ van der Spek, EV Rouwet, AH Danser, J Essers
PloS one 2011
Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis
M Urushihara, N Ohashi, K Miyata, R Satou, OW Acres, H Kobori
Hypertension 2011
EGFR Signaling Promotes TGFβ-Dependent Renal Fibrosis
J Chen, JK Chen, K Nagai, D Plieth, M Tan, TC Lee, DW Threadgill, EG Neilson, RC Harris
Journal of the American Society of Nephrology : JASN 2011
TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis
R Samarakoon, JM Overstreet, SP Higgins, PJ Higgins
Cell & Tissue Research 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production
K Siddiquee, J Hampton, S Khan, D Zadory, L Gleaves, DE Vaughan, LH Smith
Journal of Hypertension 2011
Involvement of glomerular renin−angiotensin system (RAS) activation in the development and progression of glomerular injury
S Kagami
Clinical and Experimental Nephrology 2011
New Insights and Perspectives on Intrarenal Renin-Angiotensin System: Focus on Intracrine/Intracellular Angiotensin II*
JL Zhuo, XC Li
Peptides 2011
Renal (pro)renin receptor contributes to development of diabetic kidney disease through TGFβ1-CTGF signaling cascade
J Huang, LC Matavelli, HM Siragy
Clinical and experimental pharmacology & physiology 2011
Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications
JM López-Novoa, AB Rodríguez-Peña, A Ortiz, C Martínez-Salgado, FJ Hernández
Journal of Translational Medicine 2011
Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases
JL Barnes, Y Gorin
Kidney international. Supplement 2011
The Ayurvedic medicine Salacia oblonga attenuates diabetic renal fibrosis in rats: suppression of angiotensin II/AT1 signaling
L He, Y Qi, X Rong, J Jiang, Q Yang, J Yamahara, M Murray, Y Li
Evidence-based complementary and alternative medicine : eCAM 2011
Angiotensin II type I receptor blockade suppresses glomerular renin-angiotensin system activation, oxidative stress, and progressive glomerular injury in rat anti- glomerular basement membrane glomerulonephritis
Y Kinoshita, S Kondo, M Urushihara, K Suga, S Matsuura, M Takamatsu, M Shimizu, A Nishiyama, H Kawachi, S Kagami
Translational Research 2011
The role of the renin–angiotensin system in thoracic aortic aneurysms: Clinical implications
E Moltzer, J Essers, JH van Esch, JW Roos-Hesselink, AH Danser
Pharmacology & Therapeutics 2011
Association between two genetic polymorphisms of the renin-angiotensin-aldosterone system and diabetic nephropathy: a meta-analysis
W Ding, F Wang, Q Fang, M Zhang, J Chen, Y Gu
Molecular Biology Reports 2011
Postnatal Renal Abnormalities in Rats Exposed to Losartan during Lactation
EC Marin, HD Francescato, CG da Silva, RS Costa, TM Coimbra
Nephron Experimental Nephrology 2011
Blood Pressure Lowering Effect of a Pea Protein Hydrolysate in Hypertensive Rats and Humans
H Li, N Prairie, CC Udenigwe, AP Adebiyi, PS Tappia, HM Aukema, PJ Jones, RE Aluko
Journal of Agricultural and Food Chemistry 2011
Furosemide induces mortality in a rat model of chronic heart failure
H Rokutan, C Suckow, S Haehling, S Strassburg, B Bockmeyer, W Doehner, C Waller, J Bauersachs, K Websky, B Hocher, SD Anker, J Springer
International Journal of Cardiology 2011
Renoprotective efficacy of valsartan in chronic non-diabetic proteinuric nephropathies with renin-angiotensin system gene polymorphisms
YJ Lee, HR Jang, SG Kim, DW Chae, JY Do, JE Lee, W Huh, DJ Kim, HY Oh, YG Kim
Nephrology 2011
Masa ventricular izquierda, función diastólica y marcadores de metabolismo del colágeno en la hipertensión arterial refractaria
CM Blanco, D Fatela-Cantillo, L Jiménez-Jiménez, RL Aguilar, R Moreno-Luna, AD Delgado, P Stiefel
Medicina Clínica 2011
Serum transforming growth factor-beta levels in patients with vitamin D deficiency
S Isik, U Ozuguz, YA Tutuncu, G Erden, D Berker, K Acar, Y Aydin, G Akbaba, N Helvaci, S Guler
European Journal of Internal Medicine 2011
Regulation of a novel angiotensin II precursor, proangiotensin-12, in the tissues by blockade of the rennin–angiotensin system
R Satou, H Kobori
Hypertension Research 2011
Irbesartan delays progression of nephropathy as measured by estimated glomerular filtration rate: post hoc analysis of the Irbesartan Diabetic Nephropathy Trial
M Evans, SC Bain, S Hogan, RW Bilous
Nephrology Dialysis Transplantation 2011
Angiotensinogen Expression Is Enhanced in the Progression of Glomerular Disease
M Urushihara, H Kobori
International Journal of Clinical Medicine 2011
A low-dose combination of valsartan and low molecular weight heparin better improved glomerular permeability than did high-dose monotherapy in rats with diabetic nephropathy
B Jiao, Y Zhang, Y Cheng, J Gao, Q Zhang
Drug discoveries & therapeutics 2011
Jak2-Independent Activation of Stat3 by Intracellular Angiotensin II in Human Mesangial Cells
R Singh
Journal of Signal Transduction 2011
Angiotensin II Sustains Brain Inflammation in Mice via Transforming Growth Factor Beta
Tobias Lanz, Zhaoqing Ding, Peggy Ho, Jian Luo, Ankur Agrawal, Hrishikesh Srinagesh, Robert Axtell, Hui Zhang, Michael Platten, Tony Wyss-Coray, Lawrence Steinman
Journal of Clinical Investigation 2010
Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension
M Ryuzaki, A Ichihara, Y Ohshima, M Sakoda, A Kurauchi-Mito, T Narita, K Kinouchi, K Murohashi-Bokuda, A Nishiyama, H Itoh
Hypertension Research 2010
Oxidative Stress in Diabetic Nephropathy
Kashihara N, Haruna Y, Kondeti VK, Kanwar YS
Current medicinal chemistry 2010
Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF-β1 synthesis
F Mihout, N Shweke, N Bigé, C Jouanneau, JC Dussaule, P Ronco, C Chatziantoniou, JJ Boffa
The Journal of Pathology 2010
Tissue Renin-Angiotensin-Aldosterone Systems: Targets for Pharmacological Therapy
M Bader
Annual Review of Pharmacology and Toxicology 2010
New insights into the renoprotective actions of the renin inhibitor aliskiren in experimental renal disease
DL Feldman
Hypertension Research 2010
Vascular Basement Membrane Thickening in Diabetic Retinopathy
S Roy, J Ha, K Trudeau, E Beglova
Current Eye Research 2010
Common pathophysiological mechanisms of chronic kidney disease: Therapeutic perspectives
JM López-Novoa, C Martínez-Salgado, AB Rodríguez-Peña, FJ Hernández
Pharmacology & Therapeutics 2010
Stimulation of Reactive Oxygen Species and Collagen Synthesis by Angiotensin II in Cardiac Fibroblasts
PJ Lijnen, JF van Pelt, RH Fagard
Cardiovascular Therapeutics 2010
High glucose-induced apoptosis in bovine retinal pericytes is associated with transforming growth factor β and βIG-H3: βIG-H3 induces apoptosis in retinal pericytes by releasing Arg-Gly-Asp peptides
JH Han, SW Ha, IK Lee, BW Kim, JG Kim
Clinical & Experimental Ophthalmology 2010
Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: current status
TK Ma, KK Kam, BP Yan, YY Lam
British Journal of Pharmacology 2010
Urinary angiotensinogen accurately reflects intrarenal Renin-Angiotensin system activity
M Urushihara, S Kondo, S Kagami, H Kobori
American Journal of Nephrology 2010
Enhanced angiotensin-converting enzyme 2 attenuates angiotensin II-induced collagen production via AT1 receptor–phosphoinositide 3-kinase–Akt pathway
L Bu, S Qu, X Gao, JJ Zou, W Tang, LL Sun, ZM Liu
Endocrine 2010
Fibronectin synthesis by high glucose level mediated proliferation of mouse embryonic stem cells: Involvement of ANG II and TGF-β1
YH Kim, JM Ryu, YJ Lee, HJ Han
Journal of Cellular Physiology 2010
Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet
K Tashiro, S Takai, D Jin, H Yamamoto, K Komeda, M Hayashi, K Tanaka, N Tanigawa, M Miyazaki
Hepatology Research 2010
Angiotensin AT1 receptor activation mediates high glucose-induced epithelial-mesenchymal transition in renal proximal tubular cells
L Zhou, H Xue, P Yuan, J Ni, C Yu, Y Huang, LM Lu
Clinical and Experimental Pharmacology and Physiology 2010
Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters
K Komeda, S Takai, D Jin, K Tashiro, M Hayashi, N Tanigawa, M Miyazaki
Hepatology Research 2010
Tranilast attenuates the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy
SM Tan, Y Zhang, AJ Cox, DJ Kelly, W Qi
Nephrology Dialysis Transplantation 2010
A review of mast cells and liver disease: What have we learned?
H Francis, CJ Meininger
Digestive and Liver Disease 2010
Differential expression of angiotensin II type 1 and type 2 receptors at the maternal-fetal interface: potential roles in early placental development
CL Tower, S Lui, NR Charlesworth, SD Smith, JD Aplin, RL Jones
Reproduction 2010
Angiotensin II mediates epithelial-to-mesenchymal transformation in tubular cells by ANG 1–7/MAS-1-dependent pathways
WC Burns, E Velkoska, R Dean, LM Burrell, MC Thomas
American journal of physiology. Renal physiology 2010
Glomerular type 1 (AT1) angiotensin receptors augment kidney injury and inflammation in autoimmune nephritis
Steven D. Crowley, Matthew Vasievich, Phillip Ruiz, Samantha K. Gould, Kelly K. Parsons, A. Kathy Pazmino, Benny J. Chen, Hyung-Suk Kim, Trinh T. Tran, David S. Pisetsky, Laura Barisoni, Minolfa C. Ptrieto-Carrasquero, Marie Jeansson, Mary H. Foster and Thomas M. Coffman
Journal of Clinical Investigation 2009
Vascular consequences of dietary salt intake
PW Sanders
American journal of physiology. Renal physiology 2009
Mechanism of VEGF expression by high glucose in proximal tubule epithelial cells
D Feliers, BS Kasinath
Molecular and Cellular Endocrinology 2009
Mechanisms of renal injury and progression of renal disease in congenital obstructive nephropathy
RL Chevalier, BA Thornhill, MS Forbes, SC Kiley
Pediatric Nephrology 2009
Protective Effect of Tanshinone IIA on the Early Stage of Experimental Diabetic Nephropathy
SK Kim, KH Jung, BC Lee
Biological & Pharmaceutical Bulletin 2009
The Rowett rat strain is resistant to renal fibrosis
G Kokeny, Z Nemeth, M Godo, P Hamar
Nephrology Dialysis Transplantation 2009
The Role of Na+-H+Exchanger Isoform 1 in Aldosterone-Induced Glomerulosclerosis in Vivo
M Zhang, J Chen, S Liu, L You, S Lin, Y Gu
Renal Failure 2009
Inhibition of intracellular Angiotensin II formation blocks high glucose effect on mesangial matrix
R Singh, D Choubey, J Chen, DJ Leehey
Regulatory Peptides 2009
Aldosterone-induced TGF-β1Expression is Regulated by Mitogen-Activated Protein Kinases and Activator Protein-1 in Mesangial Cells
JS Han, BS Choi, CW Yang, YS Kim
Journal of Korean Medical Science 2009
Losartan chemistry and its effects via AT1 mechanisms in the kidney
F Xu, C Mao, Y Liu, L Wu, Z Xu, L Zhang
Current medicinal chemistry 2009
The Relationship between Thymic Size and Vesicoureteral Reflux in Infants with Febrile Urinary Tract Infection
SK Jung, KH Park, HE Yim, KH Yoo, YS Hong, JW Lee
Journal of the Korean Society of Pediatric Nephrology 2009
Renoprotective effect of rosuvastatin in DOCA-salt hypertensive rats
EH Bae, IJ Kim, JW Park, SK Ma, JU Lee, SW Kim
Nephrology Dialysis Transplantation 2009
Angiotensin II activates connective tissue growth factor and induces extracellular matrix changes involving Smad/activation and p38 mitogen-activated protein kinase signalling pathways in human dermal fibroblasts
GY Zhang, X Li, CG Yi, H Pan, GD He, Q Yu, LF Jiang, WH Xu, ZJ Li, J Ding, DS Lin, WY Gao
Experimental Dermatology 2009
Combination Therapy with SMP-534 and an Angiotensin-Converting Enzyme Inhibitor Provides Additional Renoprotection in 5/6 Nephrectomized Rats
T Tsujimura, J Nagamine, E Sugaru, M Ono-Kishino, T Tokunaga, M Kitoh, R Nagata, T Nakagawa, M Taiji
Biological & Pharmaceutical Bulletin 2009
Rehmannia glutinosa ameliorates the progressive renal failure induced by 5/6 nephrectomy
BC Lee, JB Choi, HJ Cho, YS Kim
Journal of Ethnopharmacology 2009
Ocular Manifestations of Scleroderma
R Tailor, A Gupta, A Herrick, J Kwartz
Survey of Ophthalmology 2009
Intramuscular renin–angiotensin system is activated in human muscular dystrophy
G Sun, K Haginoya, H Dai, Y Chiba, M Uematsu, N Hino-Fukuyo, A Onuma, K Iinuma, S Tsuchiya
Journal of the Neurological Sciences 2009
Survival in type 2 diabetic patients in dialysis and the number of risk alleles in polymorphisms of the renin-angiotensin system genes
A Padromiquel, P Aliaramos, M Gonzalezalvarez, M Navarromoreno
Clinical Biochemistry 2009
Genetic Diseases of the Kidney
K Ichida, M Hosoyamada, T Hosoya, H Endou
Genetic Diseases of the Kidney 2009
Peptide Hormone Regulation of Angiogenesis
C Clapp, S Thebault, MC Jeziorski, GM de la Escalera
Physiological reviews 2009
Vascular consequences of dietary salt intake
PW Sanders
American journal of physiology. Renal physiology 2009
Roles of mitogen-activated protein kinases and angiotensin II in renal development
AP Balbi, HD Francescato, EC Marin, RS Costa, TM Coimbra
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2009
JunD and HIF-1α mediate transcriptional activation of angiotensinogen by TGF-β1 in human lung fibroblasts
A Abdul-Hafez, R Shu, BD Uhal
The FASEB Journal 2009
Angiotensin-(1–7) activates growth-stimulatory pathways in human mesangial cells
J Zimpelmann, KD Burns
American journal of physiology. Renal physiology 2009
NOX enzymes and diabetic complications
T Kakehi, C Yabe-Nishimura
Seminars in Immunopathology 2008
Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase
Z Zhang, Y Zhang, G Ning, DK Deb, J Kong, YC Li
Proceedings of the National Academy of Sciences 2008
Expression of AT1 and AT2 angiotensin receptors in astrocytomas is associated with poor prognosis
O Arrieta, B Pineda-Olvera, P Guevara-Salazar, N Hernández-Pedro, D Morales-Espinosa, TL Cerón-Lizarraga, CH la Rosa, D Rembao, B Segura-Pacheco, J Sotelo
British Journal of Cancer 2008
Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aorta
JM Luther, Z Wang, J Ma, N Makhanova, HS Kim, NJ Brown
Endocrinology 2008
Novel mechanisms of protein synthesis in diabetic nephropathy--role of mRNA translation
BS Kasinath, MM Mariappan, K Sataranatarajan, MJ Lee, GG Choudhury, D Feliers
Reviews in Endocrine and Metabolic Disorders 2008
Therapy in Nephrology & Hypertension
WL Whittier, JB Lewis, EJ Lewis
Therapy in Nephrology & Hypertension 2008
Fever Duration and Renal Scar in Pediatric Urinary Tract Infection
JI Jung, DH Lim, HE Yim, MS Park, KH Yoo, YS Hong, JW Lee
Journal of the Korean Society of Pediatric Nephrology 2008
Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy
M Takamatsu, M Urushihara, S Kondo, M Shimizu, T Morioka, T Oite, H Kobori, S Kagami
Pediatric Nephrology 2008
VASOPRESSIN STIMULATES THE PRODUCTION OF EXTRACELLULAR MATRIX BY CULTURED RAT MESANGIAL CELLS
A Tahara, J Tsukada, Y Tomura, T Suzuki, T Yatsu, M Shibasaki
Clinical and Experimental Pharmacology and Physiology 2008
Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Type 1 Receptor Blockade on Streptozotocin-Induced Diabetic Nephropathy
S Sen, M Kanter, S Ustundag, C Aktas, H Dogutan, O Yalcin
Renal Failure 2008
Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection
N Perico, A Benigni, G Remuzzi
Nature Reviews Drug Discovery 2008
Low-Dose Losartan Therapy Reduces Proteinuria in Normotensive Patients with Immunoglobulin A Nephropathy
A SHIMIZU, T TAKEI, K UCHIDA, K TSUCHIYA, K NITTA
Hypertension Research 2008
Olmesartan Ameliorates Progressive Glomerular Injury in Subtotal Nephrectomized Rats through Suppression of Superoxide Production
S FUJIMOTO, M SATOH, H HORIKE, H HATTA, Y HARUNA, S KOBAYASHI, T NAMIKOSHI, S ARAKAWA, N TOMITA, N KASHIHARA
Hypertension Research 2008
Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenicRen-2rats
KJ Wiggins, V Tiauw, Y Zhang, RE Gilbert, RG Langham, DJ Kelly
Nephrology 2008
Influence of Cytokine Gene Polymorphisms on IgA Nephropathy
C Bantis, P Heering, S Aker, N Kuhr, B Grabensee, K Ivens
Renal Failure 2008
Fibrosis in diabetes complications: pathogenic mechanisms and circulating and urinary markers
CR Ban, SM Twigg
Vascular Health and Risk Management 2008
Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice
Y Waseda, M Yasui, Y Nishizawa, K Inuzuka, H Takato, Y Ichikawa, A Tagami, M Fujimura, S Nakao
Respiratory Research 2008
Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension
SD Crowley, CW Frey, SK Gould, R Griffiths, P Ruiz, JL Burchette, DN Howell, N Makhanova, M Yan, HS Kim, PL Tharaux, TM Coffman
American journal of physiology. Renal physiology 2008
Angiotensin II- and glucose-stimulated extracellular matrix production: mediation by the insulin-like growth factor (IGF) axis in a murine mesangial cell line
LK Davis, BD Rodgers, KM Kelley
Endocrine 2008
The renin-angiotensin system and diabetes: an update
A Ribeiro-Oliveira, AI Nogueira, RM Pereira, WW Boas, RA Santos, AC Silva
Vascular Health and Risk Management 2008
Rosiglitazone Treatment Attenuates Expression of Inflammatory Hallmarks in the Remaining Kidney following Contralateral Nephrectomy
S Efrati, S Berman, A Chachashvili, N Cohen, Z Averbukh, J Weissgarten
American Journal of Nephrology 2008
MAPK and angiotensin II receptor in kidney of newborn rats from losartan-treated dams
AP Balbi, EC Marin, HD Francescato, RS Costa, TM Coimbra
Pediatric Nephrology 2008
Pathological Regression by Angiotensin II Type 1 Receptor Blockade in Patients with Mesangial Proliferative Glomerulonephritis
T OHTAKE, M OKA, K MAESATO, T MANO, R IKEE, H MORIYA, S KOBAYASHI
Hypertension Research 2008
Laminin and transforming growth factor beta-1 in children with vesicoureteric reflux
A Sabasiñska, W Zoch-Zwierz, A Wasilewska, T Porowski
Pediatric Nephrology 2008
Understanding the role of genetic polymorphisms in chronic kidney disease
K Luttropp, P Stenvinkel, JJ Carrero, R Pecoits-Filho, B Lindholm, L Nordfors
Pediatric Nephrology 2008
A positive effect of AII inhibitors on peritoneal membrane function in long-term PD patients
I Kolesnyk, M Noordzij, FW Dekker, EW Boeschoten, RT Krediet
Nephrology Dialysis Transplantation 2008
Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation
G Carvajal, J Rodríguez-Vita, R Rodrigues-Díez, E Sánchez-López, M Rupérez, C Cartier, V Esteban, A Ortiz, J Egido, SA Mezzano, M Ruiz-Ortega
Kidney International 2008
Transforming growth factor- 1 is associated with kidney damage in patients with essential hypertension: renoprotective effect of ACE inhibitor and/or angiotensin II receptor blocker
S Zhu, Y Liu, L Wang, QH Meng
Nephrology Dialysis Transplantation 2008
All-transretinoic acid inhibits the increases in fibronectin and PAI-1 induced by TGF-β1 and Ang II in rat mesangial cells1
X LIU, L LÜ, B TAO, Y ZHU
Acta Pharmacologica Sinica 2008
ACE inhibitors and angiotensin II receptor antagonists in Crohn’s disease management
GE Hume, GL Radford-Smith
Expert Review of Gastroenterology & Hepatology 2008
Targeting the angiotensin pathway in idiopathic pulmonary fibrosis
SA Antoniu
Expert Opinion on Therapeutic Targets 2008
Effect of Pentoxifylline in Addition to Losartan on Proteinuria and GFR in CKD: A 12-Month Randomized Trial
SL Lin, YM Chen, WC Chiang, KD Wu, TJ Tsai
American Journal of Kidney Diseases 2008
Glomerular renin angiotensin system in streptozotocin diabetic and Zucker diabetic fatty rats
DJ Leehey, AK Singh, JP Bast, P Sethupathi, R Singh
Translational Research 2008
Renin–angiotensin system blockade in diabetic nephropathy
J Ahmad
Diabetes and Metabolic Syndrome Clinical Research and Reviews 2008
Renal Protective Effects of Leukotriene Receptor Blockers in an Experimental Model of Cyclosporine Nephrotoxicity
A Atakan, H Arikan, B Macunluoglu, S Tuglular, G Ulfer, F Cakalagaoglu, C Ozener, E Akoglu
Transplantation Proceedings 2008
Effects of Spironolactone in an Experimental Model of Chronic Cyclosporine Nephrotoxicity
B Macunluoglu, H Arikan, A Atakan, S Tuglular, G Ulfer, F Cakalagaoglu, C Ozener, E Akoglu
Transplantation Proceedings 2008
Local renal aldosterone production induces inflammation and matrix formation in kidneys of diabetic rats: Aldosterone and renal inflammation
HM Siragy, C Xue
Experimental Physiology 2008
Aldosterone and TGF- 1 synergistically increase PAI-1 and decrease matrix degradation in rat renal mesangial and fibroblast cells
W Huang, C Xu, KW Kahng, NA Noble, WA Border, Y Huang
AJP Renal Physiology 2008
Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension
SD Crowley, CW Frey, SK Gould, R Griffiths, P Ruiz, JL Burchette, DN Howell, N Makhanova, M Yan, HS Kim, PL Tharaux, TM Coffman
American journal of physiology. Renal physiology 2008
Intracellular ANG II directly induces in vitro transcription of TGF-β1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT 1a receptors
XC Li, JL Zhuo
American journal of physiology. Cell physiology 2008
Angiotensin II increases the expression of the transcription factor ETS-1 in mesangial cells
DD Pearse, RX Tian, J Nigro, JB Iorgulescu, L Puzis, EA Jaimes
American journal of physiology. Renal physiology 2008
Systemic and local effects of angiotensin II blockade in experimental diabetic nephropathy
P Vieitez, O Gómez, ER Uceda, ME Vera, E Molina-Holgado
Journal of Renin-Angiotensin-Aldosterone System 2008
In-Stent Restenosis of the Renal Artery in a Single Kidney Patient: The Role of ACEI in the Therapeutic Choice
R Cianci, A Gigante, L Polidori, DD Donato, P Martina, B Barbano, R Renzulli, A Zaccaria, G Fuiano
Angiology 2008
Transforming Growth Factor-β in Cancer Therapy, Volume II
SB Jakowlew
2008
Effect of valsartan on the expression of angiotensin II receptors in the lung of chronic antigen exposure rats:
T WANG, K YIN, K LIU, G LU, Y LI, J CHEN
Chinese Medical Journal 2008
Diuretic Renography in Hydronephrosis: Delayed Tissue Tracer Transit Accompanies Both Functional Decline and Tissue Reorganization
A Schlotmann, JH Clorius, WK Rohrschneider, SN Clorius, F Amelung, K Becker
Journal of Nuclear Medicine 2008
MAPK and angiotensin II receptor in kidney of newborn rats from losartan-treated dams
AP Balbi, EC Marin, HD Francescato, RS Costa, TM Coimbra
Pediatric Nephrology 2008
Understanding the role of genetic polymorphisms in chronic kidney disease
K Luttropp, P Stenvinkel, JJ Carrero, R Pecoits-Filho, B Lindholm, L Nordfors
Pediatric Nephrology 2008
Laminin and transforming growth factor beta-1 in children with vesicoureteric reflux
A Sabasiñska, W Zoch-Zwierz, A Wasilewska, T Porowski
Pediatric Nephrology 2008
Crucial role of Rho-nuclear factor-kappaB axis in angiotensin II-induced renal injury
Y Ozawa, H Kobori
American journal of physiology. Renal physiology 2007
Pathogenesis and Classification of Proliferative Diabetic Vitreoretinopathy
P Kroll, EB Rodrigues, S Hoerle
Ophthalmologica 2007
Anti-inflammatory Renoprotective Effect of Clopidogrel and Irbesartan in Chronic Renal Injury
X Tu, X Chen, Y Xie, S Shi, J Wang, Y Chen, J Li
Journal of the American Society of Nephrology : JASN 2007
Expression of Angiotensin II Receptor Type 1 Is Reduced in Advanced Rat Liver Fibrosis
U Töx, I Scheller, N Kociok, MA Kern, D Klanac, SM Daudi, O Laue, P Schirmacher, T Goeser, S Schulte, HM Steffen
Digestive Diseases and Sciences 2007
Functional renin receptors in renal mesangial cells.
Huang Y, Border WA, Noble NA
Current Hypertension Reports 2007
Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells
S Giunti, GH Tesch, S Pinach, DJ Burt, ME Cooper, P Cavallo-Perin, G Camussi, G Gruden
Diabetologia 2007
Nitric oxide and vascular remodeling: Spotlight on the kidney
W Eberhardt, J Pfeilschifter
Kidney International 2007
Angiotensin II Receptor Blockade Ameliorates Mesangioproliferative Glomerulonephritis in Rats through Suppression of CTGF and PAI-1, Independently of the Coagulation System
N Liu, S Shimizu, T Ito-Ihara, K Takagi, T Kita, T Ono
Nephron Experimental Nephrology 2007
Functional renin receptors in renal mesangial cells
Y Huang, WA Border, NA Noble
Current Hypertension Reports 2007
Novel therapies blocking the renin–angiotensin–aldosterone system in the management of hypertension and related disorders
H Krum, RE Gilbert
Journal of Hypertension 2007
Angiotensin mediates renal fibrosis in the nephropathy of glycogen storage disease type Ia
WH Yiu, CJ Pan, RA Ruef, WT Peng, MF Starost, BC Mansfield, JY Chou
Kidney International 2007
New insights into the importance of aminopeptidase A in hypertension
S Mizutani, M Ishii, A Hattori, S Nomura, Y Numaguchi, M Tsujimoto, H Kobayshi, T Murohara, JW Wright
Heart Failure Reviews 2007
Enhanced TGF-b/Smad signaling in the early stage of diabetic nephropathy is independent of the AT1a receptor
Y Okazaki, Y Yamasaki, HA Uchida, K Okamoto, M Satoh, K Maruyama, Y Maeshima, H Sugiyama, T Sugaya, N Kashihara, H Makino
Clinical and Experimental Nephrology 2007
Resolving fibrosis in the diseased liver: Translating the scientific promise to the clinic
AK Muddu, IN Guha, AM Elsharkawy, DA Mann
The International Journal of Biochemistry & Cell Biology 2007
The Renin-Angiotensin System and Diabetic Nephropathy
SB Gurley, TM Coffman
Seminars in Nephrology 2007
Sphingosylphosphorylcholine stimulates expression of fibronectin through TGF-β1-Smad-dependent mechanism in human mesenchymal stem cells
HJ Moon, ES Jeon, YM Kim, MJ Lee, CK Oh, JH Kim
The International Journal of Biochemistry & Cell Biology 2007
Therapeutic potential of TGF-β inhibition in chronic renal failure
E Gagliardini, A Benigni
Expert Opinion on Biological Therapy 2007
TGF-β in Renal Injury and Disease
EP Böttinger
Seminars in Nephrology 2007
Effect of ACE inhibitors on angiotensin II in rat mesangial cells cultured in high glucose
R Singh, DJ Leehey
Biochemical and Biophysical Research Communications 2007
Mast cells and inflammatory kidney disease
U Blank, M Essig, L Scandiuzzi, M Benhamou, Y Kanamaru
Immunological Reviews 2007
Blockade of renin?angiotensin system in antifibrotic therapy
H Yoshiji, S Kuriyama, H Fukui
Journal of Gastroenterology and Hepatology 2007
Angiotensin receptor antagonist vs. angiotensin-converting enzyme inhibitor in Asian subjects with type 2 diabetes and albuminuria ? a randomized crossover study
SC Lim, AF Koh, SK Goh, CL Chua, BL Heng, T Subramaniam, CF Sum
Diabetes, Obesity and Metabolism 2007
Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis
K Kitamura, S Tada, N Nakamoto, K Toda, H Horikawa, S Kurita, S Tsunematsu, N Kumagai, H Ishii, H Saito, T Hibi
Journal of Gastroenterology and Hepatology 2007
The Effects of Angiotensin-Converting Enzyme Inhibitors on the Fibrous Envelope around Mammary Implants
OA Zimman, J Toblli, I Stella, M Ferder, L Ferder, F Inserra
Plastic and Reconstructive Surgery 2007
The up-regulation of angiotensin II receptor type 1 and connective tissue growth factor are involved in high-glucose-induced fibronectin production by cultured human dermal fibroblasts
N Yevdokimova, S Podpryatov
Journal of Dermatological Science 2007
Renoprotective role of the vitamin D receptor in diabetic nephropathy
Z Zhang, L Sun, Y Wang, G Ning, AW Minto, J Kong, RJ Quigg, YC Li
Kidney International 2007
Differential gene expression in response to transforming growth factor-β1 by fetal and postnatal dermal fibroblasts
KJ Rolfe, LM Irvine, AO Grobbelaar, C Linge
Wound Repair and Regeneration 2007
Losartan-hydrochlorothiazide association promotes lasting blood pressure normalization and completely arrests long-term renal injury in the 5/6 ablation model
CK Fujihara, DM Malheiros, R Zatz
American journal of physiology. Renal physiology 2007
The blockade of the renin-angiotensin system reverses tacrolimus related cardiovascular toxicity at the histopathological level
M Agirbasli, N Papila-Topal, B Ogutmen, H Deniz, F Cakalagaoglu, S Tuglular, E Akoglu
Journal of Renin-Angiotensin-Aldosterone System 2007
A Novel Phosphoinositide 3-Kinase-dependent Pathway for Angiotensin II/AT-1 Receptor-mediated Induction of Collagen Synthesis in MES-13 Mesangial Cells
N Yano, D Suzuki, M Endoh, TC Zhao, JF Padbury, YT Tseng
The Journal of biological chemistry 2007
Captopril Reduces Interstitial Renal Fibrosis and Preserves More Normal Renal Tubules in Neonatal Dogs with Partial Urethral Obstruction: A Preliminary Study
M Shirazi, A Noorafshan, MA Bahri, N Tanideh
Urologia Internationalis 2007
The Combination of ACE Inhibition plus Sympathetic Denervation Is Superior to ACE Inhibitor Monotherapy in the Rat Renal Ablation Model
P Hamar, G Kokeny, P Liptak, J Krtil, M Adamczak, K Amann, E Ritz, ML Gross
Nephron Experimental Nephrology 2007
Effects of Renin-Angiotensin System Blockade on Macrophage Infiltration in Patients with Hypertensive Nephrosclerosis
T IMAKIIRE, Y KIKUCHI, M YAMADA, T KUSHIYAMA, K HIGASHI, N HYODO, K YAMAMOTO, T ODA, S SUZUKI, S MIURA
Hypertension Research 2007
Impact of ACE Inhibitors and AII Receptor Blockers on Peritoneal Membrane Transport Characteristics in Long-Term Peritoneal Dialysis Patients
I Kolesnyk, FW Dekker, M Noordzij, S le Cessie, DG Struijk, RT Krediet
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2007
Loss of ACE2 leads to a late development of angiotensin II dependent glomerulosclerosis and compartmentalization of renal injury
Gavin Y. Oudit, Andrew M. Herzenberg, Zamaneh Kassiri, Mark C. Chappell, Heather Reich, Rama Khokha, Michael A. Crackower, Peter H. Backx, Josef M. Penninger, James W. Scholey
The American Journal of Pathology 2006
Plasminogen activator inhibitor-1 deficiency protects against aldosterone-induced glomerular injury
J Ma, A Weisberg, JP Griffin, DE Vaughan, AB Fogo, NJ Brown
Kidney International 2006
The link between Glut-1 and hypertension in diabetic nephropathy
L Gnudi, L Raij
Current Hypertension Reports 2006
ACE inhibition reduces glomerulosclerosis and regenerates glomerular tissue in a model of progressive renal disease
A Remuzzi, E Gagliardini, F Sangalli, M Bonomelli, M Piccinelli, A Benigni, G Remuzzi
Kidney International 2006
Interacting molecule of AT1 receptor, ATRAP, is colocalized with AT1 receptor in the mouse renal tubules
Y Tsurumi, K Tamura, Y Tanaka, Y Koide, M Sakai, M Yabana, Y Noda, T Hashimoto, M Kihara, N Hirawa, Y Toya, Y Kiuchi, M Iwai, M Horiuchi, S Umemura
Kidney International 2006
Combinational effect of genes for the renin–angiotensin system in conferring susceptibility to diabetic nephropathy
N Osawa, D Koya, S Araki, T Uzu, T Tsunoda, A Kashiwagi, Y Nakamura, S Maeda
Journal of Human Genetics 2006
Blockade of the renin–angiotensin–aldosterone system: a key therapeutic strategy to reduce renal and cardiovascular events in patients with diabetes
M Burnier, A Zanchi
Journal of Hypertension 2006
Renal injury due to renin–angiotensin–aldosterone system activation of the transforming growth factor-β pathway
G Wolf
Kidney International 2006
Renin increases mesangial cell transforming growth factor-β1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
Y Huang, S Wongamorntham, J Kasting, D McQuillan, RT Owens, L Yu, NA Noble, W Border
Kidney International 2006
Preventive and therapeutic effects of angiotensin II type 1 receptor blocker on hepatic fibrosis induced by bile duct ligation in rats
M Ueki, M Koda, S Yamamoto, Y Matsunaga, Y Murawaki
Journal of Gastroenterology 2006
Renal artery stenosis and accelerated atherosclerosis: which comes first?
C Fava, P Minuz, P Patrignani, A Morganti
Journal of Hypertension 2006
Angiotensin II-stimulated collagen production in cardiac fibroblasts is mediated by reactive oxygen species
P Lijnen, I Papparella, V Petrov, A Semplicini, R Fagard
Journal of Hypertension 2006
Pharmacological management of renal fibrotic disease
J Gaedeke, HH Neumayer, H Peters
Expert Opinion on Pharmacotherapy 2006
Angiotensinogen and transforming growth factor beta1: novel genes in the pathogenesis of Crohn's disease
GE Hume, EV Fowler, D Lincoln, R Eri, D Templeton, TH Florin, JA Cavanaugh, GL Radford-Smith
Journal of medical genetics 2006
Young Scholars Award Lecture: Intratubular angiotensinogen in hypertension and kidney diseases
H Kobori, Y Ozawa, Y Suzaki, MC Prieto-Carrasquero, A Nishiyama, T Shoji, EP Cohen, LG Navar
American Journal of Hypertension 2006
Effect of salt intake on progression of chronic kidney disease
PW Sanders
Current Opinion in Nephrology and Hypertension 2006
Aldosterone promotes fibronectin production through a Smad2-dependent TGF-β1 pathway in mesangial cells
L Lai, J Chen, CM Hao, S Lin, Y Gu
Biochemical and Biophysical Research Communications 2006
Accurate Measurement and Clinical Significance of Urinary Transforming Growth Factor-Beta<sub>1</sub>
S Tsakas, DS Goumenos
American Journal of Nephrology 2006
The aetiology and pathogenesis of chronic allograft nephropathy
PJ Yates, ML Nicholson
Transplant Immunology 2006
Polymorphism of the renin–angiotensin–aldosterone system in patients with chronic allograft dysfunction
K Ayed, S Ayed-Jendoubi, TB Abdallah, R Bardi, Y Gorgi, I Sfar, B Dhrif, E Abderrahim, A Kheder
Transplant Immunology 2006
Cyclosporine reduction causes decreasing of angiotensin II and transforming growth factor-beta expression in chronic allograft nephropathy
MR Weir, JC Papadimitriou, CI Drachenberg, H Song, ST Bartlett, C Wei
Journal of Cardiothoracic-Renal Research 2006
Impact of Lotensin and Salviae on the Changes of TGF-Beta1 and Its Receptors in a Rat Model of Chronic Cyclosporine-Induced Nephropathy
B Peng, M Li, T Niu, S He
Transplantation Proceedings 2006
Inhibition of the Renin Angiotensin System Decreases Fibrogenic Cytokine Expression in Tacrolimus Nephrotoxicity in Rats
H Deniz, B Öğütmen, F Çakalağaoğlu, S Tuğlular, Ç Özener, E Akoğlu
Transplantation Proceedings 2006
Transforming Growth Factor-  in Human Diabetic Nephropathy: Effects of ACE inhibition
RG Langham, DJ Kelly, RM Gow, Y Zhang, DJ Cordonnier, N Pinel, P Zaoui, RE Gilbert
Diabetes care 2006
Short-term nitric oxide inhibition induces progressive nephropathy after regression of initial renal injury
CK Fujihara, CR Sena, DM Malheiros, AL Mattar, R Zatz
American journal of physiology. Renal physiology 2006
Microalbuminúria: fator de risco cardiovascular e renal subestimado na prática clínica
MT Zanella
Arquivos brasileiros de endocrinologia e metabologia 2006
Angiotensin II formation in the kidney and nephrosclerosis in Ren-2 hypertensive rats
A Hartner, M Porst, B Klanke, N Cordasic, R Veelken, KF Hilgers
Nephrology Dialysis Transplantation 2006
The Diabetic Kidney
P Cortes, CE Mogensen
2006
Renovascular Hypertension: A Unique Cause of Unilateral Focal Segmental Glomerulosclerosis
B ALCHI, A SHIRASAKI, I NARITA, S NISHI, M UENO, T SAEKI, S MIYAMURA, F GEJYO
Hypertension Research 2006
Dual Blockade of the Renin-Angiotensin System in the Progression of Renal Disease: The Need for More Clinical Trials
G Fernandez-Juárez, V Barrio, SG de Vinuesa, M Goicoechea, M Praga, J Luño
Journal of the American Society of Nephrology : JASN 2006
Molecular Mechanisms and Therapeutic Strategies of Chronic Renal Injury: Role of Rho-Kinase in the Development of Renal Injury
K Hayashi, S Wakino, T Kanda, K Homma, N Sugano, T Saruta
Journal of Pharmacological Sciences 2006
Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney
CC Hou, W Wang, XR Huang, P Fu, TH Chen, D Sheikh-Hamad, HY Lan
The American Journal of Pathology 2005
Up-regulation of glomerular COX-2 by angiotensin II: Role of reactive oxygen species
EA Jaimes, RX Tian, D Pearse, L Raij
Kidney International 2005
Blockage of angiotensin II type I receptor decreases the synthesis of growth factors and induces apoptosis in C6 cultured cells and C6 rat glioma
O Arrieta, P Guevara, E Escobar, R García-Navarrete, B Pineda, J Sotelo
British Journal of Cancer 2005
Tissue-Specific Expression of Renin-Angiotensin System Components in IgA Nephropathy
C Miyake-Ogawa, M Miyazaki, K Abe, T Harada, Y Ozono, H Sakai, T Koji, S Kohno
American Journal of Nephrology 2005
An extremely high dose of losartan affords superior renoprotection in the remnant model
CK Fujihara, M Velho, DM Malheiros, R Zatz
Kidney International 2005
Imidapril, an Angiotensin-Converting Enzyme Inhibitor, Reduces Diabetes-Induced Renal Oxidative Damage in Mice
Y Naito, K Uchiyama, S Akagiri, W Aoi, G Hasegawa, N Nakamura, S Kokura, N Yoshida, H Ichikawa, S Toyokuni, T Yoshikawa
Journal of Clinical Biochemistry and Nutrition 2005
Renoprotective Effect of Early Inhibition of the Renin-Angiotensin System in Renal Transplant Recipients
D Montanaro, M Gropuzzo, P Tulissi, C Vallone, G Boscutti, R Mioni, A Risaliti, U Baccarani, GL Adani, M Sainz, F Bresadola, G Mioni
Transplantation Proceedings 2005
Agents in development for the treatment of diabetic nephropathy
K Fukami, ME Cooper, JM Forbes
Expert Opinion on Investigational Drugs 2005
Bone morphogenetic proteins in development and homeostasis of kidney
P Simic, S Vukicevic
Cytokine & Growth Factor Reviews 2005
Suppressive Effects of Iron on TGF-&beta;<sub>1</sub> Production by Renal Proximal Tubular Epithelial Cells
T Horino, H Ito, T Yamaguchi, M Furihata, K Hashimoto
Nephron Experimental Nephrology 2005
Dual angiotensin-converting enzyme/neutral endopeptidase inhibition on cardiac and renal fibrosis and inflammation in DOCA-salt hypertensive rats
Q Pu, F Amiri, P Gannon, EL Schiffrin
Journal of Hypertension 2005
Angiotensin II receptor blocker inhibits p27Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruli
ZG Xu, TH Yoo, DR Ryu, HC Park, SK Ha, DS Han, SG Adler, R Natarajan, SW Kang
Kidney International 2005
Levels of transforming growth factor beta 1 in south Indian type 2 diabetic subjects
V Viswanathan, C Snehalatha, MB Nair, R Kumutha, A Ramachandran
Diabetes/Metabolism Research and Reviews 2005
LOW RENIN-ANGIOTENSIN SYSTEM ACTIVITY GENE POLYMORPHISM AND DYSPLASIA ASSOCIATED WITH POSTERIOR URETHRAL VALVES
L Peruzzi, F Lombardo, A Amore, E Merlini, G Restagno, L Silvestro, T Papalia, R Coppo
The Journal of Urology 2005
Can Angiotensin Converting Enzyme Inhibitors Prevent Postoperative Adhesions?
N Bulbuller, YS Ilhan, C Kirkil, M Cetiner, Ö Gogebakan, N Ilhan
Journal of Surgical Research 2005
Advanced glycation end-product induces fractalkine gene upregulation in normal rat glomeruli
Y Kikuchi, T Imakiire, T Hyodo, T Kushiyama, K Higashi, N Hyodo, S Suzuki, S Miura
Nephrology Dialysis Transplantation 2005
Can Advanced Glycation End Product Inhibitors Modulate More than One Pathway to Enhance Renoprotection in Diabetes?
MT Coughlan, ME Cooper, JM Forbes
Annals of the New York Academy of Sciences 2005
The Renoprotective Potential of Pentoxifylline in Chronic Kidney Disease
SL Lin, WC Chiang, YM Chen, CF Lai, TJ Tsai, BS Hsieh
Journal of the Chinese Medical Association 2005
Effect of Valsartan versus Lisinopril on Peritoneal Sclerosis in Rats
S Duman, S ŞEn, C Duman, DG Oreopoulos
The International Journal of Artificial Organs 2005
POSTERIOR URETHRAL VALVES: PRELIMINARY OBSERVATIONS ON THE SIGNIFICANCE OF PLASMA RENIN ACTIVITY AS A PROGNOSTIC MARKER
M Bajpai, A Pratap, MA Tripathi, C Bal
The Journal of Urology 2005
Expression and Response to Angiotensin-Converting Enzyme Inhibition of Matrix Metalloproteinases 2 and 9 in Renal Glomerular Damage in Young Transgenic Rats with Renin-Dependent Hypertension
J Bolbrinker, S Markovic, M Wehland, WB Melenhorst, H van Goor, R Kreutz
The Journal of pharmacology and experimental therapeutics 2005
Angiotensin II Mediates High Glucose-Induced TGF-β1 and Fibronectin Upregulation in HPMC through Reactive Oxygen Species
H Noh, H Ha, MR Yu, YO Kim, JH Kim, HB Lee
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2005
Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1
KN Lai, LY Chan, SC Tang, AW Tsang, FF Li, MF Lam, SL Lui, JC Leung
Kidney International 2004
Translational regulation of vascular endothelial growth factor expression in renal epithelial cells by angiotensin II
D Feliers, S Duraisamy, JL Barnes, G Ghosh-Choudhury, BS Kasinath
American journal of physiology. Renal physiology 2004
Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors
Y Kawaguchi, K Takagi, M Hara, C Fukasawa, T Sugiura, E Nishimagi, M Harigai, N Kamatani
Arthritis & Rheumatism 2004
Androgen Contributes to Gender-Related Cardiac Hypertrophy and Fibrosis in Mice Lacking the Gene Encoding Guanylyl Cyclase-A
Y Li, I Kishimoto, Y Saito, M Harada, K Kuwahara, T Izumi, I Hamanaka, N Takahashi, R Kawakami, K Tanimoto, Y Nakagawa, M Nakanishi, Y Adachi, DL Garbers, A Fukamizu, K Nakao
Endocrinology 2004
Microvascular complications of diabetes
Z He, GL King
Endocrinology & Metabolism Clinics of North America 2004
AGEs activate mesangial TGF-beta-Smad signaling via an angiotensin II type I receptor interaction
K Fukami, S Ueda, S Yamagishi, S Kato, Y Inagaki, M Takeuchi, Y Motomiya, R Bucala, S Iida, K Tamaki, T Imaizumi, ME Cooper, S Okuda
Kidney International 2004
From Hyperglycemia to Diabetic Kidney Disease: The Role of Metabolic, Hemodynamic, Intracellular Factors and Growth Factors/Cytokines
BF Schrijvers, AS Vriese, A Flyvbjerg
Endocrine reviews 2004
Diabetic nephropathy: Linking histology, cell biology, and genetics
S Adler
Kidney International 2004
Dual Effects of Endothelin-1 (1-31): Induction of Mesangial Cell Migration and Facilitation of Monocyte Recruitment through Monocyte Chemoattractant Protein-1 Production by Mesangial Cells
K ISHIZAWA, M YOSHIZUMI, K TSUCHIYA, H HOUCHI, K MINAKUCHI, Y IZAWA, Y KANEMATSU, S KAGAMI, M HIROSE, T TAMAKI
Hypertension Research 2004
The role of bradykinin in the antifibrotic actions of perindoprilat on human mesangial cells
IZ Pawluczyk, SR Patel, KP Harris
Kidney International 2004
Combining TGF-beta inhibition and angiotensin II blockade results in enhanced antifibrotic effect
L Yu, WA Border, I Anderson, M McCourt, Y Huang, NA Noble
Kidney International 2004
Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist
M Otsuka, H Takahashi, M Shiratori, H Chiba, S Abe
Thorax 2004
An ACE inhibitor reduces Th2 cytokines and TGF-beta1 and TGF-beta2 isoforms in murine lupus nephritis
DA de Albuquerque, V Saxena, DE Adams, GP Boivin, HI Brunner, DP Witte, RR Singh
Kidney International 2004
Combination Therapy with Angiotensin-Converting Enzyme Inhibitor and Oral Adsorbent of Uremic Toxins Can Delay the Appearance of Glomerular Sclerosis and Interstitial Fibrosis in Established Renal Failure
K Okada, E Okawa, H Shibahara, T Maruyama, N Maruyama, K Matsumoto, S Takahashi
Kidney and Blood Pressure Research 2004
Role of nitric oxide in diabetic nephropathy
SS Prabhakar
Seminars in Nephrology 2004
Effect of Angiotensin II on Glomerular Structure in Streptozotocin-Induced Diabetic Rats
SB Nicholas, M Mauer, JM Basgen, E Aguiniga, Y Chon
American Journal of Nephrology 2004
PREVENTION OF RENAL FIBROSIS BY SPIRONOLACTONE IN MICE WITH COMPLETE UNILATERAL URETERAL OBSTRUCTION
H Trachtman, AC Weiser, E Valderrama, M Morgado, LS Palmer
The Journal of Urology 2004
Review Article. Pentoxifylline: A potential therapy for chronic kidney disease
SL Lin, YM Chen, WC Chiang, TJ Tsai, WY Chen
Nephrology 2004
Transforming growth factor beta1 at clinical onset of Type 1 diabetes mellitus. A pilot study
L Flores, S Naf, R Hernaez, I Conget, R Gomis, E Esmatjes
Diabetic Medicine 2004
Hypertension, transforming growth factor-β, angiotensin II and kidney disease
A Bobik
Journal of Hypertension 2004
Imidapril improves l-NAME-exacerbated nephrosclerosis with TGF-β1 inhibition in spontaneously hypertensive rats
H Ono, M Saitoh, Y Ono, T Ishimitu, H Matsuoka
Journal of Hypertension 2004
Role of endothelin ETB receptor in partial ablation-induced chronic renal failure in rats
Y Okada, M Nakata, H Izumoto, M Takasu, N Tazawa, M Takaoka, CE Gariepy, M Yanagisawa, Y Matsumura
European Journal of Pharmacology 2004
Antifibrotic effect of the Chinese herbs, Astragalus mongholicus and Angelica sinensis, in a rat model of chronic puromycin aminonucleoside nephrosis
H Wang, J Li, L Yu, Y Zhao, W Ding
Life Sciences 2004
.BETA.1-integrins and glomerular injury
S Kagami, S Kondo
The Journal of Medical Investigation 2004
Renal synthesis of urokinase type-plasminogen activator, its receptor, and plasminogen activator inhibitor-1 in diabetic nephropathy in rats: Modulation by angiotensin-converting–enzyme inhibitor
M Kenichi, M Masanobu, K Takehiko, T Shoko, F Akira, A Katsushige, H Takashi, O Yoshiyuki, K Shigeru
Journal of Laboratory and Clinical Medicine 2004
Renal allograft protection with early angiotensin-converting enzyme inhibitors administration
D Montanaro, M Gropuzzo, P Tulissi, G Boscutti, R Mioni, A Risaliti, U Baccarani, GL Adani, M Sainz, F Bresadola, G Mioni
Transplantation Proceedings 2004
Effect of aldosterone on renal transforming growth factor- 
I Juknevicius
AJP Renal Physiology 2004
Angiotensin II type 1 receptor interaction is an important regulator for the development of pancreatic fibrosis in mice
Y Nagashio, H Asaumi, S Watanabe, Y Nomiyama, M Taguchi, M Tashiro, T Sugaya, M Otsuki
AJP Gastrointestinal and Liver Physiology 2004
High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells
DB Vidotti, DE Casarini, PC Cristovam, CA Leite, N Schor, MA Boim
American journal of physiology. Renal physiology 2004
Ultrastructural alterations in capillaries of the diabetic hypertensive rat retina: protective effects of ACE inhibition
AA Dosso, E Rungger-Brändle, PM Leuenberger
Diabetologia 2004
Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: a mechanism for activation of latent TGF-β 1
T Naito, T Masaki, DJ Nikolic-Paterson, C Tanji, N Yorioka, N Kohno
American journal of physiology. Renal physiology 2004
Postnatal renal development of rats from mothers that received increased sodium intake
AP Balbi, RS Costa, TM Coimbra
Pediatric Nephrology 2004
Hexosamines and TGF-β 1 use similar signaling pathways to mediate matrix protein synthesis in mesangial cells
LP Singh, K Green, M Alexander, S Bassly, ED Crook
American journal of physiology. Renal physiology 2004
Molecular and clinical response to angiotensin�II receptor antagonist in kidney transplant patients with chronic allograft nephropathy
VR Mas, T Alvarellos, DG Maluf, A Ferreira-Gonzalez, L Oliveros, RA Maldonado, G Boccardo
Transplant International 2004
Urinary transforming growth factor-β1 in various types of nephropathy
PD Muro, R Faedda, P Fresu, A Masala, A Cigni, G Concas, MG Mela, A Satta, A Carcassi, GM Sanna, GM Cherchi
Pharmacological research : the official journal of the Italian Pharmacological Society 2004
Beneficial Effect of Angiotensin-Blocking Agents on Graft Fibrosis in Hepatitis C Recurrence after Liver Transplantation:
A Rimola, MC Londoo, G Guevara, M Bruguera, M Navasa, X Forns, M Garca-Retortillo, JC Garca-Valdecasas, J Rodes
Transplantation 2004
Angiotensin Vol. II
T Unger, BA Schölkens
2004
Bone Morphogenetic Proteins: Regeneration of Bone and Beyond
S Vukicevic, KT Sampath
2004
Combination Therapy with an Angiotensin-Converting Enzyme Inhibitor and an Angiotensin II Receptor Blocker Synergistically Suppresses Chronic Pancreatitis in Rats
T Yamada, A Kuno, K Ogawa, M Tang, K Masuda, S Nakamura, T Ando, T Okamoto, H Ohara, T Nomura, T Joh, T Shirai, M Itoh
The Journal of pharmacology and experimental therapeutics 2004
The Renin–Angiotensin System and Peritoneal Dialysis
S Duman, A Breborowicz
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2004
Dietary salt intake modulates progression of antithymocyte serum nephritis through alteration of glomerular angiotensin II receptor expression
H Suzuki, T Yamamoto, N Ikegaya, A Hishida
American journal of physiology. Renal physiology 2003
Extracellular Matrix Metabolism in Diabetic Nephropathy
RM Mason, NA Wahab
Journal of the American Society of Nephrology : JASN 2003
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini
International Textbook of Diabetes Mellitus 2003
Angiotensin II and the glomerulus: Focus on diabetic kidney disease
JW Scholey
Current Hypertension Reports 2003
Long-term treatment with ramipril attenuates renal osteopontin expression in diabetic rats
C Li, CW Yang, CW Park, HJ Ahn, WY Kim, KH Yoon, SH Suh, SW Lim, JH Cha, YS Kim, J Kim, YS Chang, BK Bang
Kidney International 2003
Abnormal angiogenesis in diabetes mellitus
A Martin, MR Komada, DC Sane
Medicinal Research Reviews 2003
Hypertension Accelerates Diabetic Nephropathy in Wistar Fatty Rats, a Model of Type 2 Diabetes Mellitus, via Mitogen-Activated Protein Kinase Cascades and Transforming Growth Factor-.BETA.1
G IMAI, T SATOH, T KUMAI, M MURAO, H TSUCHIDA, Y SHIMA, G OGIMOTO, T FUJINO, S KOBAYASHI, K KIMURA
Hypertension Research 2003
Effects of Exercise Training on Glomerular Structure in Fructose-Fed Spontaneously Hypertensive Rats
K YOSHIDA, T KAWAMURA, HL XU, L JI, N MORI, M KOHZUKI
Hypertension Research 2003
A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C β inhibition
KR Tuttle, PW Anderson
American Journal of Kidney Diseases 2003
Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats
T Kanda, S Wakino, K Hayashi, K Homma, Y Ozawa, T Saruta
Kidney International 2003
Changes of angiotensin-converting enzyme activity in the pancreas of chronic hypoxia and acute pancreatitis
SP Ip, PC Kwan, CH Williams, S Pang, NM Hooper, PS Leung
The International Journal of Biochemistry & Cell Biology 2003
An angiotensin II type 1 receptor antagonist, olmesartan medoxomil, improves experimental liver fibrosis by suppression of proliferation and collagen synthesis in activated hepatic stellate cells
N Kurikawa, M Suga, S Kuroda, K Yamada, H Ishikawa
British Journal of Pharmacology 2003
Gene therapy and tissue engineering for sports medicine
J Huard, Y Li, H Peng, FH Fu
The Journal of Gene Medicine 2003
TGF-beta isoforms in renal fibrogenesis
L Yu, WA Border, Y Huang, NA Noble
Kidney International 2003
Effect of enalapril and losartan on the events that precede diabetic nephropathy in rats
RA Volpini, CG da Silva, RS Costa, TM Coimbra
Diabetes/Metabolism Research and Reviews 2003
The intrarenal renin–angiotensin system and diabetic nephropathy
RM Carey, HM Siragy
Trends in Endocrinology & Metabolism 2003
Induction of MIF synthesis and secretion by tubular epithelial cells: A novel action of angiotensin II
EK Rice, GH Tesch, Z Cao, ME Cooper, CN Metz, R Bucala, RC Atkins, DJ Nikolic-Paterson
Kidney International 2003
Diabetic nephropathy and transforming growth factor-β: transforming our view of glomerulosclerosis and fibrosis build-up
S Chen, B Jim, FN Ziyadeh
Seminars in Nephrology 2003
Cardiac allograft vasculopathy: current concepts and treatment
J Waller, NR Brook, ML Nicholson
Transplant International 2003
Evaluation of p53, bcl-2, and Interleukin-15 Levels in Gingival Crevicular Fluid of Cyclosporin A-Treated Patients
E Buduneli, F Genel, G Atilla, N Kütükçüçler
Journal of Periodontology 2003
Regulation of Glucose Transporter (GLUT1) Gene Expression by Angiotensin II in Mesangial Cells: Involvement of HB-EGF and EGF Receptor Transactivation
A NOSE, Y MORI, Y UCHIYAMA-TANAKA, N KISHIMOTO, K MARUYAMA, H MATSUBARA, T IWASAKA
Hypertension Research 2003
Role of protein kinase C-angiotensin II pathway for extracellular matrix production in cultured human mesangial cells exposed to high glucose levels
K Ikehara, H Tada, K Kuboki, T Inokuchi
Diabetes Research and Clinical Practice 2003
Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on blood pressure and the kidney
JM Thurman, RW Schrier
The American Journal of Medicine 2003
Progression of chronic renal disease
S Klahr, J Morrissey
American Journal of Kidney Diseases 2003
Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats
A Kuno, T Yamada, K Masuda, K Ogawa, M Sogawa, S Nakamura, T Nakazawa, H Ohara, T Nomura, T Joh, T Shirai, M Itoh
Gastroenterology 2003
Amino acids induce indicators of response to injury in glomerular mesangial cells
RL Meek, SK Cooney, SD Flynn, RF Chouinard, MH Poczatek, JE Murphy-Ullrich, KR Tuttle
American journal of physiology. Renal physiology 2003
Smad3 and PKCδ mediate TGF-β 1 -induced collagen I expression in human mesangial cells
CE Runyan, HW Schnaper, AC Poncelet
American journal of physiology. Renal physiology 2003
Angiotensin II mediates LDL-induced superoxide generation in mesangial cells
SY Park, CY Song, BC Kim, HK Hong, HS Lee
American journal of physiology. Renal physiology 2003
TA Repeat Variation, Npr1 Expression, and Blood Pressure: Impact of the Ace Locus
J Tremblay, DH Hum, R Sanchez, P Dumas, M Pravenec, D Křenova, V Křen, J Kuneš, Z Pausova, F Gossard, P Hamet
Hypertension 2003
Angiotensin-Converting Enzyme Inhibition but not Angiotensin II Receptor Blockade Regulates Matrix Metalloproteinase Activity in Patients with Glomerulonephritis
N Lods, P Ferrari, FJ Frey, A Kappeler, C Berthier, B Vogt, HP Marti
Journal of the American Society of Nephrology : JASN 2003
Angiotensin II AT1 Receptor Antagonists. Clinical Implications of Active Metabolites
B Schmidt, B Schieffer
Journal of Medicinal Chemistry 2003
Polymeric IgA1 from Patients with IgA Nephropathy Upregulates Transforming Growth Factor-β Synthesis and Signal Transduction in Human Mesangial Cells via the Renin-Angiotensin System
KN Lai, SC Tang, JY Guh, TD Chuang, MF Lam, LY Chan, AW Tsang, JC Leung
Journal of the American Society of Nephrology : JASN 2003
Transforming growth factor-beta1 is up-regulated by podocytes in response to excess intraglomerular passage of proteins: a central pathway in progressive glomerulosclerosis
M Abbate, C Zoja, M Morigi, D Rottoli, S Angioletti, S Tomasoni, C Zanchi, L Longaretti, R Donadelli, G Remuzzi
The American Journal of Pathology 2002
Role of Hypolipidemic Drug Clofibrate in Altering Iron Regulatory Proteins IRP1 and IRP2 Activities and Hepatic Iron Metabolism in Rats Fed a Low-Iron Diet
HL Huang, NS Shaw
Toxicology and Applied Pharmacology 2002
The Renin-Angiotensin-Aldosterone System and Fibrinolysis in Progressive Renal Disease
NJ Brown, DE Vaughan, AB Fogo
Seminars in Nephrology 2002
Response of mesangial cells to low-density lipoprotein and angiotensin II in diabetic (OLETF) rats
M Okada, T Takemura, H Yanagida, K Yoshioka
Kidney International 2002
Additive antiproteinuric effect of combined ACE inhibition and angiotensin II receptor blockade
P Ferrari, HP Marti, M Pfister, FJ Frey
Journal of Hypertension 2002
Chronic Angiotensin-Converting Enzyme Inhibition and Angiotensin II Antagonism in Rats With Chronic Renal Failure
K Yoshida, HL Xu, T Kawamura, L Ji, M Kohzuki
Journal of Cardiovascular Pharmacology 2002
The role of angiotensin II antagonism in type 2 diabetes mellitus: a review of renoprotection studies
MT Zanella, AB Ribeiro
Clinical Therapeutics 2002
Class benefits of AT1antagonists in Type 2 diabetes with nephropathy
SA Doggrell
Expert Opinion on Pharmacotherapy 2002
Angiotensin converting enzyme inhibitors and angiotensin II receptor blockers: Evidence for and against the combination in the treatment of hypertension and proteinuria
NH Andersen, CE Mogensen
Current Hypertension Reports 2002
Angiotensin II and progressive renal insufficiency
J Gaedeke, NA Noble, WA Border
Current Hypertension Reports 2002
THE ACE INHIBITOR, QUINAPRIL, AMELIORATES PERITONEAL FIBROSIS IN AN ENCAPSULATING PERITONEAL SCLEROSIS MODEL IN MICE
T Sawada, Y Ishii, T Tojimbara, I Nakajima, S Fuchinoue, S Teraoka
Pharmacological Research 2002
Renal Protective Effect of Candesartan Cilexetil in Spontaneously Hypercholesterolemic Rats
T Matsuo, E Ishikawa, M Ohta, Y Shibouta, Y Ishimura, Y Imura, Y Sugiyama
The Japanese Journal of Pharmacology 2002
Perindopril: possible use in cancer therapy
H Yoshiji, S Kuriyama, H Fukui
Anti-Cancer Drugs 2002
Effects of Angiotensin II Subtype 1 Receptor Blockade by Losartan on Tubulointerstitial Lesions Caused by Hyperoxaluria
JE Toblli, L Ferder, I Stella, EM de Cavanagh, M Angerosa, F Inserra
The Journal of Urology 2002
Increased transforming growth factor-β1 and tubulointerstitial fibrosis in rats with congenital hydronephrosis
Y Zhou, G Takahashi, T Shinagawa, T Okuhara, K Yonamine, Y Aida, M Tadokoro
International Journal of Urology 2002
Effects of amino acids and glucose on mesangial cell aminopeptidase a and angiotensin receptors
RF Chouinard, RL Meek, SK Cooney, KR Tuttle
Kidney International 2002
Myocardial fibrosis in transforming growth factor-beta1 (TGF-beta1) transgenic mice is associated with inhibition of interstitial collagenase
U Seeland, C Haeuseler, R Hinrichs, S Rosenkranz, T Pfitzner, K Scharffetter-Kochanek, M Bohm
European Journal of Clinical Investigation 2002
Towards a biological characterization of focal segmental glomerulosclerosis
P Devarajan, A Spitzer
American Journal of Kidney Diseases 2002
Renoprotective effects of valsartan and enalapril in STZ-induced diabetes in rats
B Kalender, M Öztürk, M Tunçdemir, Ö Uysal, FK Dağıstanlı, I Yeğenağa, E Erek
Acta Histochemica 2002
Expression of glomerular plasminogen activator inhibitor type 1 in glomerulonephritis
K Hamano, M Iwano, Y Akai, H Sato, A Kubo, Y Nishitani, H Uyama, Y Yoshida, M Miyazaki, H Shiiki, S Kohno, K Dohi
American Journal of Kidney Diseases 2002
Effects of Anti-α1 Integrin Subunit Antibody on Anti-Thy-1 Glomerulonephritis
S Kagami, M Urushihara, S Kondo, T Hayashi, H Yamano, K Löster, D Vossmeyer, W Reutter, Y Kuroda
Laboratory Investigation 2002
Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-β levels
R Agarwal, S Siva, SR Dunn, K Sharma
American Journal of Kidney Diseases 2002
The spectrum of long-term renal transplantation: Outcomes, complications, and clinical studies
WE Braun, NG Yadlapalli
Transplantation Reviews 2002
Upregulation of angiotensin II receptors in reflux nephropathy
B Chertin, U Rolle, S Cascio, M McDermot, S O'Briain, A Farkas, P Puri
Journal of Pediatric Surgery 2002
The Role of the Renin-Angiotensin System in Cholesterol and Puromycin Mediated Renal Injury
S Ghosh, D Sica, AC Schoolwerth, I Fakhry, TW Gehr, RJ Quigg, M Haas
The American Journal of the Medical Sciences 2002
MUSCLE INJURIES AND REPAIR: CURRENT TRENDS IN RESEARCH
J Huard, Y Li, FH Fu
The Journal of Bone and Joint Surgery. American volume. 2002
Transforming Growth Factor-β Signal Transduction and Progressive Renal Disease 1
J Cheng, JP Grande
Experimental biology and medicine (Maywood, N.J.) 2002
Experimental and clinical rationale for use of MMF in nontransplant progressive nephropathies
R Zatz, IL Noronha, CK Fujihara
American journal of physiology. Renal physiology 2002
High glucose-enhanced activation of mesangial cell p38 MAPK by ET-1, ANG II, and platelet-derived growth factor
E Tsiani, P Lekas, IG Fantus, J Dlugosz, C Whiteside
American journal of physiology. Endocrinology and metabolism 2002
Angiotensin II induces apoptosis in rat glomerular epithelial cells
G Ding, K Reddy, AA Kapasi, N Franki, N Gibbons, BS Kasinath, PC Singhal
American journal of physiology. Renal physiology 2002
Angiotensin II stimulates migration of retinal microvascular pericytes: involvement of TGF-β and PDGF-BB
JA Nadal, GM Scicli, LA Carbini, AG Scicli
American journal of physiology. Heart and circulatory physiology 2002
ACE-I and ARBs in early diabetic nephropathy
M Mauer, B Zinman, R Gardiner, KN Drummond, S Suissa, SM Donnelly, TD Strand, MS Kramer, R Klein, AR Sinaiko
Journal of Renin-Angiotensin-Aldosterone System 2002
Angiotensin II-Induced Mesangial Cell Apoptosis: Role of Oxidative Stress
S Lodha, D Dani, R Mehta, M Bhaskaran, K Reddy, G Ding, PC Singhal
Molecular Medicine 2002
Recipient ras gene variants and renal allograft function1:
J Nicod, A Richard, FJ Frey, P Ferrari
Transplantation 2002
CS-866, a New Angiotensin II Type 1 Receptor Antagonist, Ameliorates Glomerular Anionic Site Loss and Prevents Progression of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty Rats
K Koga, S Yamagishi, M Takeuchi, Y Inagaki, S Amano, T Okamoto, T Saga, Z Makita, M Yoshizuka
Molecular Medicine 2002
Improving Prognosis for Kidney Disorders
MM Avram
2002
The Angiotensin Type 1 Receptor Antagonist, Eprosartan, Attenuates the Progression of Renal Disease in Spontaneously Hypertensive Stroke-Prone Rats with Accelerated Hypertension
CT Abrahamsen, FC Barone, WG Campbell, AH Nelson, LC Contino, MA Pullen, ET Grygielko, RM Edwards, NJ Laping, DP Brooks
The Journal of pharmacology and experimental therapeutics 2002
Inhibition of TGFβ1 by Anti-TGFβ1 Antibody or Lisinopril Reduces Thyroid Fibrosis in Granulomatous Experimental Autoimmune Thyroiditis
K Chen, Y Wei, GC Sharp, H Braley-Mullen
Journal of immunology (Baltimore, Md. : 1950) 2002
Molecular and Cellular Biology of Neuroprotection in the CNS
C Alzheimer
2002
The inflammatory component in progressive renal disease—are interventions possible?
IL Noronha, CK Fujihara, R Zatz
Nephrology Dialysis Transplantation 2002
Variation in the Renin Angiotensin System throughout the Normal Menstrual Cycle
M Chidambaram, JA Duncan, VS Lai, DC Cattran, JS Floras, JW Scholey, JA Miller
Journal of the American Society of Nephrology : JASN 2002
The genetics of human hypertension
ED Crook
Seminars in Nephrology 2002
Systemic infusion of angiotensin II into normal rats activates nuclear factor-kappaB and AP-1 in the kidney: role of AT(1) and AT(2) receptors
M Ruiz-Ortega, O Lorenzo, M Rupérez, J Blanco, J Egido
The American Journal of Pathology 2001
Role of immunocompetent cells in nonimmune renal diseases
B Rodriguez-Iturbe, H Pons, J Herrera-Acosta, RJ Johnson
Kidney International 2001
Effect of Telmisartan on Angiotensin II-Mediated Collagen Gel Contraction by Adult Rat Cardiac Fibroblasts
PJ Lijnen, VV Petrov, KC Jackson, RH Fagard
Journal of Cardiovascular Pharmacology 2001
Pathogenesis of diabetic nephropathy: focus on transforming growth factor-β and connective tissue growth factor
OV Sakharova, MW Taal, BM Brenner
Current Opinion in Nephrology and Hypertension 2001
Evolving strategies for renoprotection: non-diabetic chronic renal disease
MW Taal, BM Brenner
Current Opinion in Nephrology and Hypertension 2001
Angiotensin II signaling and HB-EGF shedding via metalloproteinase in glomerular mesangial cells
Y Uchiyama-Tanaka, H Matsubara, Y Nozawa, S Murasawa, Y Mori, A Kosaki, K Maruyama, H Masaki, Y Shibasaki, S Fujiyama, A Nose, O Iba, T Hasagawa, E Tateishi, S Higashiyama, T Iwasaka
Kidney International 2001
Genetic polymorphisms of the renin-angiotensin-aldosterone system in end-stage renal disease
E Lovati, A Richard, BM Frey, FJ Frey, P Ferrari
Kidney International 2001
New immunosuppressive drugs: an update
E Pohanka
Current Opinion in Urology 2001
Identification of New Therapies for Leiomyomas: What In Vitro Studies Can Tell Us
RA Nowak
Clinical Obstetrics and Gynecology 2001
Inhibition of Progression of Heart Failure and Expression of TGF-β1 mRNA in Rats with Heart Failure by the ACE Inhibitor Quinapril
M Ma, K Watanabe, MI Wahed, M Inoue, T Sekiguchi, T Kouda, Y Ohta, M Nakazawa, Y Yoshida, T Yamamoto, H Hanawa, M Kodama, K Fuse, Y Aizawa
Journal of Cardiovascular Pharmacology 2001
PROTECTIVE ROLE OF ENALAPRIL FOR CHRONIC TUBULOINTERSTITIAL LESIONS OF HYPEROXALURIA
JE Toblli, LN Ferder, IS Stella, M Angerosa, F Inserra
The Journal of Urology 2001
Non-penetrating Vascular Clips Anastomosis Inhibited Intimal Thickening Under Poor Runoff Conditions in Canine Autogenous Vein Grafts
K Komori, T Shoji, T Furuyama, Y Yonemitsu, E Mori, T Yamaoka, T Matsumoto, K Sugimachi
European Journal of Vascular and Endovascular Surgery 2001
Increased secretion of TGF-β1 by peripheral blood mononuclear cells from patients with Type 1 diabetes mellitus with diabetic nephropathy
E Korpinen, PH Groop, JA Fagerudd, AM Teppo, HK Åkerblom, O Vaarala
Diabetic Medicine 2001
IMPAIRED NEPHROGENESIS IN RATS WITH CONGENITAL OBSTRUCTIVE UROPATHY
F Seseke, P Thelen, M Heuser, G Zöller, RH Ringert
The Journal of Urology 2001
Homozygosity for angiotensinogen 235T variant increases the risk of myocardial infarction in patients with multi-vessel coronary artery disease
O Olivieri, C Stranieri, D Girelli, F Pizzolo, S Grazioli, C Russo, PF Pignatti, R Corrocher
Journal of Hypertension 2001
Involvement of Angiotensin II in Progression of Renal Injury in Rats With Genetic Non-insulin-Dependent Diabetes Mellitus (Wistar Fatty Rats)
M Noda, T Matsuo, H Nagano, M Ohta, M Sekiguchi, Y Shibouta, T Naka, Y Imura
The Japanese Journal of Pharmacology 2001
Increased D allele frequency of the angiotensin-converting enzyme gene in pulmonary fibrosis
CD Morrison, AC Papp, AQ Hejmanowski, VM Addis, TW Prior
Human Pathology 2001
Progression of Chronic Renal Disease
S Klahr
Heart Disease 2001
High glucose levels enhance TGF-β1–thrombospondin-1 pathway in cultured human mesangial cells via mechanisms dependent on glucose-induced PKC activation
H Tada, K Kuboki, K Nomura, T Inokuchi
Journal of Diabetes and its Complications 2001
Achieving maximal renal protection in nondiabetic chronic renal disease
MW Taal, BM Brenner
American Journal of Kidney Diseases 2001
New pharmacologic aspects of CS-866, the newest angiotensin II receptor antagonist
H Koike
The American Journal of Cardiology 2001
Angiotensin II and the pathophysiology of cardiovascular remodeling
B Williams
The American Journal of Cardiology 2001
Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt DNA replication in transgenic fibroblasts
M Iwano, A Fischer, H Okada, D Plieth, C Xue, TM Danoff, EG Neilson
Molecular Therapy 2001
Mechanisms underlying renoprotection during renin-angiotensin system blockade
MW Taal, GM Chertow, HG Rennke, A Gurnani, T Jiang, A Shahsafaei, JL Troy, BM Brenner, HS Mackenzie
American journal of physiology. Renal physiology 2001
Overexpression of brain natriuretic peptide in mice ameliorates immune-mediated renal injury
T Suganami, M Mukoyama, A Sugawara, K Mori, T Nagae, M Kasahara, K Yahata, H Makino, Y Fujinaga, Y Ogawa, I Tanaka, K Nakao
Journal of the American Society of Nephrology : JASN 2001
Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis
G Paizis, RE Gilbert, ME Cooper, P Murthi, JM Schembri, LL Wu, JR Rumble, DJ Kelly, C Tikellis, A Cox, RA Smallwood, PW Angus
Journal of Hepatology 2001
Requirement for Tyrosine Kinase-ERK1/2 Signaling in α1β1 Integrin-Mediated Collagen Matrix Remodeling by Rat Mesangial Cells
S Kagami, M Urushihara, S Kondo, K Löster, W Reutter, T Tamaki, M Yoshizumi, Y Kuroda
Experimental Cell Research 2001
Estrogen-induced cardiorenal protection: potential cellular, biochemical, and molecular mechanisms
RK Dubey, EK Jackson
American journal of physiology. Renal physiology 2001
Early streptozotocin-diabetes mellitus downregulates rat kidney AT 2 receptors
GJ Wehbi, J Zimpelmann, RM Carey, DZ Levine, KD Burns
American journal of physiology. Renal physiology 2001
Glomerular hypertension—an under‐appreciated aspect of chronic rejection
LC Paul
Nephrology Dialysis Transplantation 2001
Renin-angiotensin blockade improves renal cGMP production via non-AT2-receptor mediated mechanisms in hypertension-induced by chronic NOS inhibition in rat
N Uhlenius, O Vuolteenaho, I Tikkanen
Journal of Renin-Angiotensin-Aldosterone System 2001
Molecular mechanisms of renal allograft fibrosis
JR Waller, ML Nicholson
The British journal of surgery 2001
alpha-Smooth muscle actin and proliferating cell nuclear antigen expression in focal segmental glomerulosclerosis: functional and structural parameters of renal disease progression
TJ Geleilete, RS Costa, M Dantas, TM Coimbra
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2001
Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors
PJ Lijnen, VV Petrov, RH Fagard
Journal of Renin-Angiotensin-Aldosterone System 2001
TREATMENT OF CHRONIC RENAL ALLOGRAFT REJECTION IN RATS WITH A LOW-MOLECULAR-WEIGHT HEPARIN (REVIPARIN):
C Braun, M Schultz, L Fang, M Schaub, WE Back, D Herr, V Laux, P Rohmeiss, P Schnuelle, FJ van der Woude
Transplantation 2001
Angiotensin Type 1 Receptor Antagonism and ACE Inhibition Produce Similar Renoprotection in Nω -Nitro- l >-Arginine Methyl Ester/Spontaneously Hypertensive Rats
Y Nakamura, H Ono, X Zhou, ED Frohlich
Hypertension 2001
Expression and Function of Peroxisome Proliferator–Activated Receptor-γ in Mesangial Cells
SB Nicholas, Y Kawano, S Wakino, AR Collins, WA Hsueh
Hypertension 2001
ACE Inhibitors and Appearance of Renal Events in Hypertensive Nephrosclerosis
J Segura, C Campo, JL Rodicio, LM Ruilope
Hypertension 2001
Klinische Endokrinologie und Stoffwechsel
PP Nawroth, R Ziegler
2001
Role of Mast Cell Tryptase in Renal Interstitial Fibrosis
S Kondo, S Kagami, H Kido, F Strutz, GA Müller, Y Kuroda
Journal of the American Society of Nephrology : JASN 2001
Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo
NJ Brown, S Nakamura, L Ma, I Nakamura, E Donnert, M Freeman, DE Vaughan, AB Fogo
Kidney International 2000
Renoprotective benefits of RAS inhibition: From ACEI to angiotensin II antagonists
MW Taal, BM Brenner
Kidney International 2000
Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (mRen-2)27 rat
DJ Kelly, SL Skinner, RE Gilbert, AJ Cox, ME Cooper, JL Wilkinson-Berka
Kidney International 2000
Lack of evidence of blood pressure-independent protection by renin-angiotensin system blockade after renal ablation
AK Bidani, KA Griffin, G Bakris, MM Picken
Kidney International 2000
Proinflammatory gene expression and macrophage recruitment in the rat remnant kidney
MW Taal, K Zandi-Nejad, B Weening, A Shahsafaei, S Kato, KW Lee, F Ziai, T Jiang, BM Brenner, HS Mackenzie
Kidney International 2000
Angiotensin II induces renal oxidant stress in vivo and heme oxygenase-1 in vivo and in vitro
EN Haugen, AJ Croatt, KA Nath
Kidney International 2000
Cellular and molecular mediators in common pathway mechanisms of chronic renal disease progression
MW Taal, SA Omer, MK Nadim, HS Mackenzie
Current Opinion in Nephrology and Hypertension 2000
Renal allograft protection with losartan in FisherLewis rats: Hemodynamics, macrophages, and cytokines
F Ziai, H Nagano, M Kusaka, AJ Coito, JL Troy, KC Nadeau, HG Rennke, NL Tilney, BM Brenner, HS Mackenzie
Kidney International 2000
Role of angiotensin II in diabetic nephropathy
DJ Leehey, AK Singh, N Alavi, R Singh
Kidney International 2000
ACE inhibitors and angiotensin II antagonists in renal transplantation: An analysis of safety and efficacy
CE Stigant, J Cohen, M Vivera, JS Zaltzman
American Journal of Kidney Diseases 2000
Calcium channel blockers and angiotensin-converting enzyme inhibitors in the prevention of graft vasculopathy
LC Paul
The Journal of Heart and Lung Transplantation 2000
CAFFEINE AUGMENTS PROTEINURIA IN PUROMYCIN-AMINONUCLEOSIDE NEPHROTIC RATS1*
SP Tofovic, BR Rominski, S Bastacky, EK Jackson, CK Kost
Renal Failure 2000
Activated STAT1 suppresses proliferation of cultured rat mesangial cells
O Nakashima, Y Terada, S Hanada, K Yamamoto, M Kuwahara, S Sasaki, F Marumo
Kidney International 2000
Effect of angiotensin-converting enzyme inhibition on growth factor mRNA in chronic renal allograft rejection in the rat
A Szabo, J Lutz, K Schleimer, B Antus, P Hamar, T Philipp, U Heemann
Kidney International 2000
Angiotensin II blockade and low-protein diet produce additive therapeutic effects in experimental glomerulonephritis
H Peters, WA Border, NA Noble
Kidney International 2000
Tandem antifibrotic actions of L-arginine supplementation and low protein diet during the repair phase of experimental glomerulonephritis
H Peters, WA Border, NA Noble
Kidney International 2000
Vasoactive substances in renal transplantation
D Demetriou, C Wenter, B Watschinger
Current Opinion in Urology 2000
ANGIOTENSIN II TYPE 1 RECEPTOR ANTAGONIST (LOSARTAN) DOWN-REGULATES TRANSFORMING GROWTH FACTOR-β IN EXPERIMENTAL ACUTE PYELONEPHRITIS
A Khalil, K Tullus, M Bakhiet, LG Burman, G Jaremko, A Brauner
The Journal of Urology 2000
ANGIOTENSIN II TYPE 1 RECEPTOR ANTAGONIST (LOSARTAN) DOWN-REGULATES TRANSFORMING GROWTH FACTOR-?? IN EXPERIMENTAL ACUTE PYELONEPHRITIS
A Khalil, K Tullus, M Bakhiet, LG Burman, G Jaremko, A Brauner
The Journal of Urology 2000
Smad proteins and transforming growth factor-beta signaling
M Schiffer, GV Gersdorff, M Bitzer, K Susztak, EP Bottinger
Kidney International 2000
Plasminogen activator inhibitor type 1 is a potential target in renal fibrogenesis
JP Rerolle, A Hertig, G Nguyen, JD Sraer, EP Rondeau
Kidney International 2000
Osteopontin expression in progressive renal injury in remnant kidney: Role of angiotensin II
XQ Yu, LL Wu, XR Huang, N Yang, RE Gilbert, ME Cooper, RJ Johnson, KN Lai, HY Lan
Kidney International 2000
The HOPE Study: practical implications for people with diabetes
B Kennon, M Fisher
Practical Diabetes International 2000
Activation of transforming growth factor-β1 in diabetic kidney disease
B Hellmich, M Schellner, H Schatz, A Pfeiffer
Metabolism 2000
Molecular mechanism of diabetic nephropathy
R Lehmann, ED Schleicher
Clinica Chimica Acta 2000
Role of leukocyte adhesion molecules in monocyte/macrophage infiltration in weanling rats with unilateral ureteral obstruction
A Takeda, A Fukuzaki, H Kaneto, S Ishidoya, Y Ogata, T Sasaki, R Konda, K Sakai, S Orikasa
International Journal of Urology 2000
TUMOR NECROSIS FACTOR-?? AND TUMOR GROWTH FACTOR-??1 GENOTYPE: PARTIAL ASSOCIATION WITH INTRAGRAFT GENE EXPRESSION IN TWO CASES OF LONG-TERM PERIPHERAL TOLERANCE TO A KIDNEY TRANSPLANT1
WJ Burlingham, PJ O???Connell, LM Jacobson, BN Becker, AD Kirk, V Pravica, IV Hutchinson
Transplantation 2000
Effects of imidapril and captopril on streptozotocin-induced diabetic nephropathy in mice
M Katoh, Y Ohmachi, Y Kurosawa, H Yoneda, N Tanaka, H Narita
European Journal of Pharmacology 2000
ACE inhibitors attenuate expression of renal transforming growth factor-β1 in humans
GT Shin, SJ Kim, KA Ma, HS Kim, D Kim
American Journal of Kidney Diseases 2000
A DNA element in the alpha1 type III collagen promoter mediates a stimulatory response by angiotensin II
GM Ghiggeri, R Oleggini, L Musante, G Caridi, R Gusmano, R Ravazzolo
Kidney International 2000
Angiotensina II e hipertensión arterial: consecuencias del antagonismo de sus receptores
V Lahera, S Vázquez-Pérez, N las Heras, E Cediel, J Navarro-Cid, V Cachofeiro
Hipertensión y Riesgo Vascular 2000
Functional and structural correlates of glomerulosclerosis after renal mass reduction in the rat
KA Griffin, MM Picken, M Churchill, P Churchill, AK Bidani
Journal of the American Society of Nephrology : JASN 2000
Ameliorated glomerular injury in mice overexpressing brain natriuretic peptide with renal ablation
M Kasahara, M Mukoyama, A Sugawara, H Makino, T Suganami, Y Ogawa, M Nakagawa, K Yahata, M Goto, R Ishibashi, N Tamura, I Tanaka, K Nakao
Journal of the American Society of Nephrology : JASN 2000
Expression of LOX-1, an oxidized low-density lipoprotein receptor, in experimental hypertensive glomerulosclerosis
M Nagase, S Kaname, T Nagase, G Wang, K Ando, T Sawamura, T Fujita
Journal of the American Society of Nephrology : JASN 2000
Angiotensin II and its receptors in the diabetic kidney
KD Burns
American Journal of Kidney Diseases 2000
ACE gene polymorphism and renal responsiveness to ACE inhibitors in IgA nephropathy patients
S Y Han, Y J Kwon, S K Jo, J H Shin, D R Cha, W Y Cho, H J Pyo, H K Kim
The Korean Journal of Internal Medicine 2000
The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease
S Klahr, JJ Morrissey
Kidney International 2000
Gene expression in rats with renal disease treated with the angiotensin II receptor antagonist, eprosartan
VY Wong, NJ Laping, LC Contino, BA Olson, E Grygielko, DP Brooks
Physiological genomics 2000
Dietary docosahexaenoic acid ameliorates, but rapeseed oil and safflower oil accelerate renal injury in stroke-prone spontaneously hypertensive rats as compared with soybean oil, which is associated with expression for renal transforming growth factor-β, fibronectin and renin
M Miyazaki, N Takemura, S Watanabe, N Hata, Y Misawa, H Okuyama
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2000
Biology of Renal Aging in Humans
B Clark
Advances in renal replacement therapy 2000
Hexosamine regulation of glucose-mediated laminin synthesis in mesangial cells involves protein kinases A and C
LP Singh, ED Crook
American journal of physiology. Renal physiology 2000
GLUT‐1 and TGF‐β: the link between hyperglycaemia and diabetic nephropathy
G Gambaro, M Ceol, DD Prete, A D'Angelo
Nephrology Dialysis Transplantation 2000
Aminopeptidase-A. II. Genomic cloning and characterization of the rat promoter
Q Jiang, M Troyanovskaya, G Jayaraman, DP Healy
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2000
Selective estrogen receptor modulators suppress mesangial cell collagen synthesis
J Neugarten, A Acharya, J Lei, S Silbiger
American journal of physiology. Renal physiology 2000
Should the use of short acting angiotensin-converting enzyme inhibitors be abandoned?
A Erman, G Boner, DJ van Dijk
Journal of Renin-Angiotensin-Aldosterone System 2000
THE ROLE OF TRANSFORMING GROWTH FACTOR BETA IN CHRONIC RENAL ALLOGRAFT NEPHROPATHY:
S Jain, PN Furness, ML Nicholson
Transplantation 2000
Blood Pressure–Independent Effects in Rats With Human Renin and Angiotensinogen Genes
E Mervaala, DN Müller, F Schmidt, JK Park, V Gross, M Bader, V Breu, D Ganten, H Haller, FC Luft
Hypertension 2000
The Kidney and Hypertension in Diabetes Mellitus
CE Mogensen
2000
Effect of Angiotensin II Blockade on Renal Injury in Mineralocorticoid-Salt Hypertension
M Sorooshian, JL Olson, TW Meyer
Hypertension 2000
Locally Activated Renin-Angiotensin System Associated with TGF-β1 as a Major Factor for Renal Injury Induced by Chronic Inhibition of Nitric Oxide Synthase in Rats
M Kashiwagi, M Shinozaki, H Hirakata, K Tamaki, T Hirano, M Tokumoto, H Goto, S Okuda, M Fujishima
Journal of the American Society of Nephrology : JASN 2000
Glycosaminoglycans: Use in Treatment of Diabetic Nephropathy
G Gambaro, FJ Woude
Journal of the American Society of Nephrology : JASN 2000
Catecholamines and angiotensinogen gene expression in kidney proximal tubular cells
J S Chan, T T Wang, S L Zhang, X Chen, S Carrière
Molecular and Cellular Biochemistry 2000
Angiotensin II-induced transactivation of epidermal growth factor receptor regulates fibronectin and transforming growth factor-beta synthesis via transcriptional and posttranscriptional mechanisms
RK Dubey, EK Jackson, TF Lüscher
Journal of Clinical Investigation 1999
Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice
Y Hisada, T Sugaya, M Yamanouchi, H Uchida, H Fujimura, H Sakurai, A Fukamizu, K Murakami
Journal of Clinical Investigation 1999
Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice
RJ Fern, CM Yesko, BA Thornhill, HS Kim, O Smithies, RL Chevalier
Journal of Clinical Investigation 1999
Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice
T Matsusaka, H Katori, T Inagami, A Fogo, I Ichikawa
Journal of Clinical Investigation 1999
TGF-beta receptor expression and binding in rat mesangial cells: Modulation by glucose and cyclic mechanical strain
BL Riser, S Ladson-Wofford, A Sharba, P Cortes, K Drake, CJ Guerin, J Yee, ME Choi, PR Segarini, RG Narins
Kidney International 1999
Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats
S Kato, VA Luyckx, M Ots, KW Lee, F Ziai, JL Troy, BM Brenner, HS Mackenzie
Kidney International 1999
Pathological Expression of Renin and Angiotensin II in the Renal Tubule after Subtotal Nephrectomy
RE Gilbert, LL Wu, DJ Kelly, A Cox, JL Wilkinson-Berka, CI Johnston, ME Cooper
The American Journal of Pathology 1999
The concept of glomerular self-defense
M Kitamura, LG Fine
Kidney International 1999
Effect of candesartan cilexetil (TCV-116) in rats with chronic renal failure
M Noda, T Matsuo, R Fukuda, M Ohta, H Nagano, Y Shibouta, T Naka, K Nishikawa, Y Imura
Kidney International 1999
Blocking angiotensin II ameliorates proteinuria and glomerular lesions in progressive mesangioproliferative glomerulonephritis
T Nakamura, JE Obata, H Kimura, S Ohno, Y Yoshida, H Kawachi, F Shimizu
Kidney International 1999
The transforming growth factor beta system in kidney disease and repair: recent progress and future directions
DP Basile
Current Opinion in Nephrology and Hypertension 1999
Increased levels of transforming growth factor-beta in HIV-associated nephropathy
T Yamamoto, NA Noble, DE Miller, LI Gold, A Hishida, M Nagase, AH Cohen, WA Border
Kidney International 1999
Angiotensin-converting enzyme gene and diabetes mellitus
B Kennon, JR Petrie, M Small, JM Connell
Diabetic Medicine 1999
Angiotensin II inhibits interleukin-1beta-induced nitric oxide production in cultured rat mesangial cells
M Kihara, M Yabana, Y Toya, S Kobayashi, T Fujita, T Iwamoto, T Ishigami, S Umemura
Kidney International 1999
Captopril-induced reduction of serum levels of transforming growth Factor-β1 correlates with long-term renoprotection in insulin-dependent diabetic patients☆☆☆
K Sharma, BO Eltayeb, TA McGowan, SR Dunn, B Alzahabi, R Rohde, FN Ziyadeh, EJ Lewis
American Journal of Kidney Diseases 1999
TGF-β and fibrosis
MH Branton, JB Kopp
Microbes and Infection 1999
TGF-β: from latent to active
N Khalil
Microbes and Infection 1999
Pathophysiological Role of Growth Factors in Diabetic Kidney Disease: Focus on Innovative Therapy
A Flyvbjerg, C Hill, A Logan
Trends in Endocrinology & Metabolism 1999
Changes in collagenases and TGF-beta precede structural alterations in a model of chronic renal fibrosis
W Mo, C Brecklin, SL Garber, RH Song, AA Pegoraro, J Au, JA Arruda, G Dunea, AK Singh
Kidney International 1999
Angiotensin II type I receptor antagonist suppresses proteinuria and glomerular lesions in experimental nephritis
T Nagamatsu, K Hayashi, T Oka, Y Suzuki
European Journal of Pharmacology 1999
New insights into the genetics of preeclampsia
T Morgan, K Ward
Seminars in Perinatology 1999
Angiotensin II Inhibits Insulin-Induced egr-1 Expression in Mesangial Cells
BT Solow, A Derrien, JA Smith, L Jarett, S Harada
Archives of Biochemistry and Biophysics 1999
Angiotensin II-induced transactivation of epidermal growth factor receptor regulates fibronectin and transforming growth factor-beta synthesis via transcriptional and posttranscriptional mechanisms
RK Dubey, EK Jackson, TF Lüscher
Journal of Clinical Investigation 1999
Zonal heterogeneity in action of angiotensin-converting enzyme inhibitor on renal microcirculation: role of intrarenal bradykinin
H Matsuda, K Hayashi, K Arakawa, M Naitoh, E Kubota, M Honda, A Matsumoto, H Suzuki, T Yamamoto, F Kajiya, T Saruta
Journal of the American Society of Nephrology : JASN 1999
Juxtaglomerular cell tumor with retroperitoneal fibrosis and secondary immune-complex glomerulonephritis: A possible contribution of the renin angiotensin system to renal fibrosis
H Moriya, A Ishida, I Nakabayashi, J Nishiyama, S Kobayashi
American Journal of Kidney Diseases 1999
Remission of nephrotic syndrome in type 1 diabetes: Long-term follow-up of patients in the Captopril Study
WA Wilmer, LA Hebert, EJ Lewis, RD Rohde, F Whittier, D Cattran, AS Levey, JB Lewis, S Spitalewitz, S Blumenthal, RP Bain
American Journal of Kidney Diseases 1999
Sodium bicarbonate treatment reduces renal injury, renal production of transforming growth Factor-β, and urinary transforming growth Factor-β excretion in rats with doxorubicin-induced nephropathy
EA Baroni, RS Costa, R Volpini, TM Coimbra
American Journal of Kidney Diseases 1999
Association of TGF-beta signaling in angiotensin II-induced PAI-1 mRNA upregulation in mesangial cells: role of PKC
M Motojima, J Kakuchi, T Yoshioka
Biochimica et Biophysica Acta 1999
Transforming growth factor beta activity in urine of patients with type 2 diabetes and diabetic nephropathy
EW Rivarola, M Moyses-Neto, M Dantas, CG da-Silva, R Volpini, TM Coimbra
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 1999
LDL stimulates collagen mRNA synthesis in mesangial cells through induction of PKC and TGF-β expression
HS Lee, BC Kim, HK Hong, YS Kim
American journal of physiology. Renal physiology 1999
Angiotensin II (ATII)-inducible Platelet-derived Growth Factor A-chain Gene Expression Is p42/44 Extracellular Signal-regulated Kinase-1/2 and Egr-1-dependent and Mediated via the ATII Type 1 but Not Type 2 Receptor: INDUCTION BY ATII ANTAGONIZED BY NITRIC OXIDE
FL Day, LA Rafty, CN Chesterman, LM Khachigian
The Journal of biological chemistry 1999
CYCLOSPORINE-INDUCED INTERSTITIAL FIBROSIS AND ARTERIOLAR TGF-?? EXPRESSION WITH PRESERVED RENAL BLOOD FLOW:
JM Vieira, IL Noronha, DM Malheiros, EA Burdmann
Transplantation 1999
Angiotensin II Stimulates Collagen Synthesis in Human Vascular Smooth Muscle Cells: Involvement of the AT 1 Receptor, Transforming Growth Factor-β, and Tyrosine Phosphorylation
CM Ford, S Li, JG Pickering
Arteriosclerosis, thrombosis, and vascular biology 1999
Interaction of Angiotensin II and Mechanical Stretch on Vascular Endothelial Growth Factor Production by Human Mesangial Cells
G Gruden, S Thomas, DA Burt, W Zhou, G Chusney, L Gnudi, G VIBERTI
Journal of the American Society of Nephrology : JASN 1999
Ischaemic nephropathy—is the diagnosis excluded by heavy proteinuria?
AD Makanjuola, JE Scoble
Nephrology Dialysis Transplantation 1999
Acute and Chronic Renal Effects of Recombinant Human TGF-β2 in the Rat
FJ Kelly, S Anderson, MM Thompson, TT Oyama, TM Kennefick, CL Corless, RJ Roman, L Kurtzberg, BM Pratt, SR Ledbetter
Journal of the American Society of Nephrology : JASN 1999
α1β1 Integrin-Mediated Collagen Matrix Remodeling by Rat Mesangial Cells Is Differentially Regulated by Transforming Growth Factor-β and Platelet-Derived Growth Factor-BB
S Kagami, S Kondo, K Löster, W Reutter, T Kuhara, K Yasutomo, Y Kuroda
Journal of the American Society of Nephrology : JASN 1999
Autocrine and paracrine mechanisms in the early stages of diabetic nephropathy
G Pugliese, F Pricci, G Romeo, G Leto, L Amadio, C Iacobini, UD Mario
Journal of Endocrinological Investigation 1999
Signal transduction in hepatic stellate cells
DE Clouthier, SA Comerford, RE Hammer
Journal of Clinical Investigation 1998
High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells
V Kolm-Litty, U Sauer, A Nerlich, R Lehmann, ED Schleicher
Journal of Clinical Investigation 1998
A new model of diabetic nephropathy with progressive renal impairment in the transgenic (mRen-2)27 rat (TGR)
DJ Kelly, JL Wilkinson-Berka, TJ Allen, ME Cooper, SL Skinner
Kidney International 1998
Angiotensin II induces superoxide anion production by mesangial cells
EA Jaimes, JM Galceran, L Raij
Kidney International 1998
Serotonin enhances the production of type IV collagen by human mesangial cells
M Kasho, M Sakai, T Sasahara, Y Anami, T Matsumura, T Takemura, H Matsuda, S Kobori, M Shichiri
Kidney International 1998
Sequential effects of high glucose on mesangial cell transforming growth factor-β1 and fibronectin synthesis
JH Oh, H Ha, MR Yu, HB Lee
Kidney International 1998
Protective Effects of CGS 30440, a Combined Angiotensin-Converting Enzyme Inhibitor and Neutral Endopeptidase Inhibitor, in a Model of Chronic Renal Failure
DS Cohen, JE Mathis, RA Dotson, SR Graybill, NJ Wosu
Journal of Cardiovascular Pharmacology 1998
Renal effects of renin—angiotensin
M Franco, R Paniagua, J Herrera-Acosta
Current Opinion in Nephrology and Hypertension 1998
RENAL ANGIOTENSIN CONVERTING ENZYME PROMOTES RENAL DAMAGE DURING URETERAL OBSTRUCTION
BJ Stoneking, TE Hunley, H Nishimura, J Ma, A Fogo, T Inagami, M Tamura, MC Adams, JW Brock, V Kon
The Journal of Urology 1998
Targeting TGF-beta overexpression in renal disease: Maximizing the antifibrotic action of angiotensin II blockade
H Peters, WA Border, NA Noble
Kidney International 1998
Signal transduction in hepatic stellate cells
DE Clouthier, SA Comerford, RE Hammer
Journal of Clinical Investigation 1998
Transforming growth factor-β (TGF-β) activity in urine of patients with glomerulonephritis is related to their renal functional and structural changes
G Dominguez, R Costa, M Dantas, T Kimachi, C Piuci, T Coimbra
Nephrology 1998
Genetic polymorphisms of the renin-angiotensin system and the outcome of focal segmental glomerulosclerosis in children
Y Frishberg, R Becker-Cohen, D Halle, E Feigin, B Eisenstein, R Halevy, D Lotan, I Juabeh, N Ish-Shalom, D Magen, Y Shvil, L Sinai-Treiman, A Drukker
Kidney International 1998
Angiotensin converting enzyme inhibition reduces the expression of transforming growth factor-β1 and type IV collagen in diabetic vasculopathy
JR Rumble, RE Gilbert, A Cox, L Wu, ME Cooper
Journal of Hypertension 1998
Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis
SE Thomas, TF Andoh, RH Pichler, SJ Shankland, WG Couser, WM Bennett, RJ Johnson
Kidney International 1998
Mesangiolytic glomerulopathy in severe congestive heart failure
H Yoshida, M Yashiro, P Liang, E Muso, E Takeuchi, T Shimada, KI Sekita, T Ono, K Kanatsu, T Sugiyama, C Kawai, S Sasayama
Kidney International 1998
Upper urinary tract obstruction: experimental and clinical aspects
NGUYEN, KOGAN
BJU International 1998
Collagen Type I Modulates the Platelet-Derived Growth Factor (PDGF) Regulation of the Growth and Expression of β1 Integrins by Rat Mesangial Cells
S Kagami, S Kondo, K Löster, W Reutter, M Urushihara, A Kitamura, S Kobayashi, Y Kuroda
Biochemical and Biophysical Research Communications 1998
Significant Role of the Increase in Renin-Angiotensin System in Cardiac Hypertrophy and Renal Glomerular Sclerosis in Double Transgenic Tsukuba Hypertensive Mice Carrying Both Human Renin and Angiotensinogen Genes
T Kai, H Kino, K Sugimura, S Shimada, A Kurooka, KI Akamatsu, T Takenaka, A Fukamizu, K Murakami, K Ishikawa, R Katori
Clinical and Experimental Hypertension 1998
Efficacy and safety of losartan in the treatment of hypertension in renal transplant recipients
D Castillo, JM Campistol, L Guirado, L Capdevilla, JG Martinez, P Pereira, J Bravo, R Perez
Kidney International 1998
Attenuation of diabetes-associated mesenteric vascular hypertrophy with perindopril: Morphological and molecular biological studies
ME Cooper, Z Cao, JR Rumble, K Jandeleit, TJ Allen, RE Gilbert
Metabolism 1998
Pathophysiology of diabetic nephropathy
ME Cooper, RE Gilbert, M Epstein
Metabolism 1998
Renal expression of transforming growth factor-beta inducible gene-h3 (beta ig-h3) in normal and diabetic rats
RE Gilbert, JL Wilkinson-Berka, DW Johnson, A Cox, T Soulis, LL Wu, DJ Kelly, G Jerums, CA Pollock, ME Cooper
Kidney International 1998
Angiotensin-converting Enzyme Inhibition Delays Pulmonary Vascular Neointimal Formation
K Okada, ML Bernstein, W Zhang, DP Schuster, MD Botney
American journal of respiratory and critical care medicine 1998
Strategies to prolong long-term renal allograft function
JA Velosa
Transplantation Reviews 1998
A central role for protein kinase C overactivity in diabetic glomerulosclerosis: implications for prevention with antioxidants, fish oil, and ACE inhibitors
MF McCarty
Medical Hypotheses 1998
The use of angiotensin-converting enzyme inhibitors in renal transplant patients
LC Paul, J Zaltzman
Transplantation Reviews 1998
Combined treatments with Ninjin-youei-to (Ren-shen-yang-rong-tang) plus a suboptimal dose of prednisolone on autoimmune nephritis in MRL\lpr mice
S Nakai, T Kawakita, K Himeno, K Nomoto
International Journal of Immunopharmacology 1998
Early induction of transforming growth factor-beta via angiotensin II type 1 receptors contributes to cardiac fibrosis induced by long-term blockade of nitric oxide synthesis in rats
H Tomita, K Egashira, Y Ohara, M Takemoto, M Koyanagi, M Katoh, H Yamamoto, K Tamaki, H Shimokawa, A Takeshita
Hypertension 1998
Transforming growth factor-β1 hyperexpression in African American end-stage renal disease patients
M Suthanthiran, A Khanna, D Cukran, R Adhikarla, VK Sharma, T Singh, P August
Kidney International 1998
Glycated albumin stimulates fibronectin gene expression in glomerular mesangial cells: Involvement of the transforming growth factor-β system
FN Ziyadeh, DC Han, JA Cohen, J Guo, MP Cohen
Kidney International 1998
TGF-β type II receptor in rat renal vascular development: Localization to juxtaglomerular cells
A Liu, BJ Ballermann
Kidney International 1998
Tissue Angiotensin II Concentration in the Heart and Kidneys in Transgenic Tsukuba Hypertensive Mice
TK Atsuh
Blood Pressure 1998
Transforming growth factor β1 and renal disease in African Americans
S Klahr
Kidney International 1998
Mechanism of Angiotensin II-mediated Regulation of Fibronectin Gene in Rat Vascular Smooth Muscle Cells
K Tamura, N Nyui, N Tamura, T Fujita, M Kihara, Y Toya, I Takasaki, N Takagi, M Ishii, K Oda, M Horiuchi, S Umemura
The Journal of biological chemistry 1998
Dietary salt modulates renal production of transforming growth factor-β in rats
WZ Ying, PW Sanders
American journal of physiology. Renal physiology 1998
Salt Induces Myocardial and Renal Fibrosis in Normotensive and Hypertensive Rats
HC Yu, LM Burrell, MJ Black, LL Wu, RJ Dilley, ME Cooper, CI Johnston
Circulation 1998
Factors Influencing Arteriovenous Fistula Dysfunction in Japanese Patients on Chronic Hemodialysis
T Masaki, N Yorioka, Y Kyuden, K Yamashita, Y Taniguchi, M Yamakido, J Tanaka, S Harada
The International Journal of Artificial Organs 1998
Interactions of Transforming Growth Factor-β and Angiotensin II in Renal Fibrosis
WA Border, NA Noble
Hypertension 1998
Transcription-Modulating Drugs: A New Frontier in the Treatment of Essential Hypertension
TW Kurtz, DG Gardner
Hypertension 1998
Vascular hypertrophy in experimental diabetes. Role of advanced glycation end products
JR Rumble, ME Cooper, T Soulis, A Cox, L Wu, S Youssef, M Jasik, G Jerums, RE Gilbert
Journal of Clinical Investigation 1997
Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients
Y Pei, J Scholey, K Thai, M Suzuki, D Cattran
Journal of Clinical Investigation 1997
The renoprotective properties of angiotensin-converting enzyme inhibitors in a chronic model of membranous nephropathy are solely due to the inhibition of angiotensin II: Evidence based on comparative studies with a receptor antagonist
C Zoja, R Donadelli, D Corna, D Testa, D Facchinetti, R Maffi, E Luzzana, V Colosio, T Bertani, G Remuzzi
American Journal of Kidney Diseases 1997
Modulation of plasminogen activator inhibitor-1 in vivo: A new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition
T Oikawa, M Freeman, W Lo, DE Vaughan, A Fogo
Kidney International 1997
Tyrosine kinase dependent expression of TGF-β induced by stretch in mesangial cells
M Hirakata, S Kaname, UG Chung, N Joki, Y Hori, M Noda, Y Takuwa, T Okazaki, T Fujita, T Katoh, K Kurokawa
Kidney International 1997
The role of angiotensin II in diabetic nephropathy: Emphasis on nonhemodynamic mechanisms
G Wolf, FN Ziyadeh
American Journal of Kidney Diseases 1997
Angiotensin II and L-arginine in tissue fibrosis: More than blood pressure
H Peters, NA Noble
Kidney International 1997
Therapeutic approaches to organ fibrosis
TJ Franklin
The International Journal of Biochemistry & Cell Biology 1997
Transforming growth factor βs and wound healing
S O'Kane, MW Ferguson
The International Journal of Biochemistry & Cell Biology 1997
Renal artery stenosis and unilateral focal and segmental glomerulosclerosis
AM Alkhunaizi, A Chapman
American Journal of Kidney Diseases 1997
Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass
T Konta, N Degawa, S Kato, H Tomoike
Clinical and Experimental Nephrology 1997
Dual effects of angiotensin II on the plasminogen/plasmin system in rat mesangial cells
S Kagami, T Kuhara, K Okada, Y Kuroda, WA Border, NA Noble
Kidney International 1997
Potential Risk Factors Associated With Progressive Renal Damage in Childhood Urological Diseases
JW Brock, M Adams, T Hunley, A Wada, L Trusler, V Kon
The Journal of Urology 1997
BIOLOGICAL FUNCTIONS OF ANGIOTENSIN AND ITS RECEPTORS
T Matsusaka, I Ichikawa
Annual Review of Physiology 1997
Potential Risk Factors Associated With Progressive Renal Damage in Childhood Urological Diseases: The Role of Angiotensin-Converting Enzyme Gene Polymorphism
JW Brock, M Adams, T Hunley, A Wada, L Trusler, V Kon
The Journal of Urology 1997
Latent transforming growth factor-β: Structural features and mechanisms of activation
JS Munger, JG Harpel, PE Gleizes, R Mazzieri, I Nunes, DB Rifkin
Kidney International 1997
Growth factor antagonists for the treatment of diabetic vascular complications
RG Tilton, RA Dixon, TA Brock
Expert Opinion on Investigational Drugs 1997
MECHANISM OF FIBROSIS IN EXPERIMENTAL TACROLIMUS NEPHROTOXICITY1,2
FS Shihab, WM Bennett, AM Tanner, TF Andoh
Transplantation 1997
Sodium depletion enhances fibrosis and the expression of TGF-β1 and matrix proteins in experimental chronic cyclosporine nephropathy
FS Shihab, TF Andoh, AM Tanner, WM Bennett
American Journal of Kidney Diseases 1997
The effect of angiotensin II on plasminogen activator(PA) system in mesangial cells: the role of renin-angiotensin system in the regulation of glomerular extracellular matrix metabolism
S Kagami, T Kuhara, K Yasutomo, K Okada, S Kondo, M Urusihara, Y Morimoto, Y Kuroda
Nihon Shoni Jinzobyo Gakkai Zasshi 1997
Tacrolimus (FK506)-Associated Renal Pathology
PS Randhawa, TE Starzl, AJ Demetris
Advances in Anatomic Pathology 1997
Synergistic effect of angiotensin II type 1 receptor genotype and poor glycaemic control on risk of nephropathy in IDDM
A Doria, T Onuma, JH Warram, AS Krolewski
Diabetologia 1997
Transforming growth factor β1 and renal injury following subtotal nephrectomy in the rat: Role of the renin-angiotensin system
LL Wu, A Cox, CJ Roe, M Dziadek, ME Cooper, RE Gilbert
Kidney International 1997
Antioxidant inhibition of protein kinase C—signaled increases in transforming growth factor-beta in mesangial cells
RK Studer, PA Craven, FR Derubertis
Metabolism 1997
Imidapril inhibits increased transforming growth factor-β1 expression in remnant kidney model
A Hamaguchi, S Kim, H Wanibuchi, H Iwao
European Journal of Pharmacology 1997
Plasma angiotensin II concentrations and the effect of treatment with enalapril in dogs with proteinuria due to renal disease
CJ Piek, HP Meyer
Veterinary Quarterly 1997
Transforming growth factor-β, other growth factors, and the extracellular matrix
MA Haralson
Journal of Laboratory and Clinical Medicine 1997
Angiotensin II modulates cell growth-related events and synthesis of matrix proteins in renal interstitial fibroblasts
M Ruiz-Ortega, J Egido
Kidney International 1997
Progression of renal damage in human glomerulonephritides: Is there sleight of hand in winning the game?
FP Schena, L Gesualdo, G Grandaliano, V Montinaro
Kidney International 1997
Angiotensin II blockade decreases TGF-β1 and matrix proteins in cyclosporine nephropathy
FS Shihab, WM Bennett, AM Tanner, TF Andoh
Kidney International 1997
Microalbuminuria: A Marker to Increased Renal and Cardiovascular Risk in Diabetes Mellitus
K McKenna, C Thompson
Scottish Medical Journal 1997
Bimodal Effects of Angiotensin II on Migration of Human and Rat Smooth Muscle Cells: Direct Stimulation and Indirect Inhibition Via Transforming Growth Factor-β1
G Liu, E Espinosa, BS Oemar, TF Lüscher
Arteriosclerosis, thrombosis, and vascular biology 1997
Dual Effects of Lisinopril on Puromycin Aminonucleoside Nephrosis in Unilaterally Nephrectomized Rats
T Shinosaki, I Takagawa, N Sunagawa, Y Yonetani, H Kurihara
The Japanese Journal of Pharmacology 1997
Cigarette smoke increases gastric ulcer size in part by an angiotensin II-mediated mechanism in rats
K Seno, J H Zhu, J D Barrett, P Eggena, O U Scremin, K Lam, J W Leung, F W Leung
Digestive Diseases and Sciences 1997
Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells
T Yasuda, S Kondo, T Homma, RC Harris
Journal of Clinical Investigation 1996
Extracellular matrix, growth factors and their interactions in the pathogenesis of diabetic kidney disease
RE GILBERT, ME COOPER, G JERUMS
Nephrology 1996
Insulin and angiotensin II are additive in stimulating TGF-β1 and matrix mRNAs in mesangial cells
PW Anderson, XY Zhang, J Tian, JD Correale, XP Xi, D Yang, K Graf, RE Law, WA Hsueh
Kidney International 1996
Transforming Growth Factor β in Diabetic Nephropathy
WA Border, T Yamamoto, NA Noble
Diabetes/Metabolism Reviews 1996
Vasoactive hormones and renal sclerosis
J Egido
Kidney International 1996
Polymorphisms of the renin-angiotensin system genes in progressive renal diseases
H Yoshida, V Kon, I Ichikawa
Kidney International 1996
Angiotensinogen: Molecular biology, biochemistry and physiology
L Morgan, FB Pipkin, N Kalsheker
The International Journal of Biochemistry & Cell Biology 1996
Intragraft TGF-β1 mRNA: A correlate of interstitial fibrosis and chronic allograft nephropathy
VK Sharma, RM Bologa, GP Xu, B Li, J Mouradian, J Wang, D Serur, V Rao, M Suthanthiran
Kidney International 1996
Role of transforming growth factor-β1 in experimental chronic cyclosporine nephropathy
FS Shihab, TF Andoh, AM Tanner, NA Noble, WA Border, N Franceschini, WM Bennett
Kidney International 1996
Cyclic stretching force selectively up-regulates transforming growth factor-beta isoforms in cultured rat mesangial cells
BL Riser, P Cortes, C Heilig, J Grondin, S Ladson-Wofford, D Patterson, RG Narins
The American Journal of Pathology 1996
Advances in Structural Biology
A Ghahary, P Rajeet, EE Tredget
Advances in Structural Biology 1996
Enhanced renal sensitivity to angiotensin actions in diabetes mellitus in the rat
J Zimpelmann, D Kumar, DZ Levine, G Wehbi, JD Imig, LG Navar, KD Burns
The American journal of physiology 1996
Therapy of Idiopathic Membranous Nephropathy
G Rostoker, B Weil
Clinical immunotherapeutics 1996
Enhanced renal sensitivity to angiotensin actions in diabetes mellitus in the rat
J Zimpelmann, D Kumar, DZ Levine, G Wehbi, JD Imig, LG Navar, KD Burns
The American journal of physiology 1996
Angiotensin II induction of fibronectin biosynthesis in cultured human mesangial cells: Association with CREB transcription factor activation
NS Nahman, KL Rothe, ME Falkenhain, KM Frazer, LE Dacio, JD Madia, KL Leonhart, JC Kronenberger, DA Stauch
Journal of Laboratory and Clinical Medicine 1996
Effects and Interactions of Endothelin-1 and Angiotensin II on Matrix Protein Expression and Synthesis and Mesangial Cell Growth
D Gómez-Garre, M Ruiz-Ortega, M Ortego, R Largo, MJ López-Armada, JJ Plaza, E González, J Egido
Hypertension 1996
Pressure and Angiotensin II Synergistically Induce Aortic Fibronectin Expression in Organ Culture Model of Rabbit Aorta: Evidence for a Pressure-Induced Tissue Renin-Angiotensin System
N Bardy, R Merval, J Benessiano, JL Samuel, A Tedgui
Circulation research 1996
Extracellular matrix and the kidney
PN Furness
Journal of clinical pathology 1996
ACE Inhibitors and the Kidney: A Risk-Benefit Assessment
G Navis, HJ Faber, D de Zeeuw, PE de Jong
Drug Safety 1996
Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation
F Niimura, PA Labosky, J Kakuchi, S Okubo, H Yoshida, T Oikawa, T Ichiki, AJ Naftilan, A Fogo, T Inagami
Journal of Clinical Investigation 1995
Angiotensin II receptor subtypes in the kidney: Distribution and function
J ZHUO, D ALCORN, PJ HARRIS, J McCAUSLAND, GP ALDRED, FA MENDELSOHN
Nephrology 1995
Proteoglycan synthesis by bovine myocardial endothelial cells is increased by long-term exposure to high concentrations of glucose
DJ Klein, RM Cohen, Z Rymaszewski
Journal of Cellular Physiology 1995
ACE inhibition reduces proteinuria, glomerular lesions and extracellular matrix production in a normotensive rat model of immune complex nephritis
M Ruiz-Ortega, S González, D Serón, E Condom, C Bustos, R Largo, E González, A Ortiz, J Egido
Kidney International 1995
ACE inhibition prevents renal failure and death in uninephrectomized MWF/Ztm rats
A Remuzzi, A Benigni, B Malanchini, I Bruzzi, C Foglieni, G Remuzzi
Kidney International 1995
Angiotensin receptors: Physiology and pharmacology
GP Guthrie
Clinical Cardiology 1995
Protein kinase C signals thromboxane induced increases in fibronectin synthesis and TGF-β bioactivity in mesangial cells
RK Studer, H Negrete, PA Craven, FR DeRubertis
Kidney International 1995
Protein kinase C in diabetic nephropathy
PA Craven, RK Studer, H Negrete, FR DeRubertis
Journal of Diabetes and its Complications 1995
Angiotensin II stimulates the autocrine production of transforming growth factor-β1 in adult rat cardiac fibroblasts
AA Lee, WH Dillmann, AD McCulloch, FJ Villarreal
Journal of Molecular and Cellular Cardiology 1995
Tissue Renin-Angiotensin Systems
AK Mukhopadhyay, MK Raizada
1995
Thromboxane stimulation of mesangial cell fibronectin synthesis is signalled by protein kinase C and modulated by cGMP
RK Studer, PA Craven, FR DeRubertis
Kidney International 1994
Increased glomerular capillary pressure alters glomerular cytokine expression
SJ Shankland, H Ly, K Thai, JW Scholey
Circulation research 1994
Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology
V Fuster
Circulation 1994

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