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Research Article Free access | 10.1172/JCI117178

Permselectivity in thin membrane nephropathy.

D M Thomas, G A Coles, D F Griffiths, and J D Williams

Institute of Nephrology, University of Wales College of Medicine, Cardiff Royal Infirmary, Cardiff, United Kingdom.

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Institute of Nephrology, University of Wales College of Medicine, Cardiff Royal Infirmary, Cardiff, United Kingdom.

Find articles by Coles, G. in: JCI | PubMed | Google Scholar

Institute of Nephrology, University of Wales College of Medicine, Cardiff Royal Infirmary, Cardiff, United Kingdom.

Find articles by Griffiths, D. in: JCI | PubMed | Google Scholar

Institute of Nephrology, University of Wales College of Medicine, Cardiff Royal Infirmary, Cardiff, United Kingdom.

Find articles by Williams, J. in: JCI | PubMed | Google Scholar

Published May 1, 1994 - More info

Published in Volume 93, Issue 5 on May 1, 1994
J Clin Invest. 1994;93(5):1881–1884. https://doi.org/10.1172/JCI117178.
© 1994 The American Society for Clinical Investigation
Published May 1, 1994 - Version history
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Abstract

The glomerular permselectivity to polydisperse neutral dextrans was compared in 6 patients with thin membrane nephropathy (TMN) and 10 healthy controls. Despite having normal renal hemodynamics and minimal proteinuria, the patients with TMN had significantly increased fractional clearance of neutral molecules with Stokes radius > 42 A. Conventional theories of glomerular barrier size selectivity cannot fully explain these data since they would predict that our patients would have had nephrotic range proteinuria.

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