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Citations to this article

Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta.
L Rudnicka, … , S A Jimenez, J Uitto
L Rudnicka, … , S A Jimenez, J Uitto
Published April 1, 1994
Citation Information: J Clin Invest. 1994;93(4):1709-1715. https://doi.org/10.1172/JCI117154.
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Research Article

Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta.

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Abstract

A hallmark of systemic sclerosis (SSc) is the development of tissue fibrosis. Excessive production of several connective tissue components normally present in the dermis, including type I, III, V, and VI collagens as well as fibronectin and proteoglycans, is a consistent finding in the skin of SSc patients. Type VII collagen is a major constituent of anchoring fibrils, present in the skin at the dermal-epidermal basement membrane zone. TGF-beta has been shown to upregulate the expression of the type VII collagen gene. In this study, we assessed the expression of type VII collagen and TGF-beta in the skin of patients with SSc. Indirect immunofluorescence showed an abundance of type VII collagen in the patients' skin, including the dermis. Ultrastructural analysis of SSc skin revealed an abundance of fibrillar material, possibly representing type VII collagen. The increased expression of type VII collagen epitopes was accompanied by the elevated expression of immunodetectable TGF-beta 1 and TGF-beta 2. Dermal fibroblasts cultured from the affected individuals showed a statistically significant (P < 0.02) increase in the expression of type VII collagen at the mRNA level, as detected by reverse transcription-PCR with a mutated cDNA as an internal standard, and increased deposition of the protein as assessed by indirect immunofluorescence. Thus, type VII collagen is abundantly present in SSc patients' dermis, a location not characteristic of its normal distribution, and its aberrant expression may relate to the presence of TGF-beta in the same topographic distribution. The presence of type VII collagen in the dermis may contribute to the tightly bound and indurated appearance of the affected skin in SSc patients.

Authors

L Rudnicka, J Varga, A M Christiano, R V Iozzo, S A Jimenez, J Uitto

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Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
B Hinz, SH Phan, VJ Thannickal, M Prunotto, A Desmoulière, J Varga, OD Wever, M Mareel, G Gabbiani
The American Journal of Pathology 2012
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McKee's Pathology of the Skin 2012
Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis
N Aden, A Nuttall, X Shiwen, P Winter, A Leask, CM Black, CP Denton, DJ Abraham, RJ Stratton
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Histomorphometric analysis of cutaneous remodeling in the early stage of the scleroderma model
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Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer
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Fibrosis in Systemic Sclerosis
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Autocrine TGF-β signaling in the pathogenesis of systemic sclerosis
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Elevated expression of isopeptide bond cross-links contributes to fibrosis in scleroderma and the healing wounds of tight skin mice
JC Sullivan, DD Kakati, E Carter, AK Boyd, TR Kyriakides, A Agah
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2008
Transforming Growth Factor-β in Cancer Therapy, Volume I
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2008
Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts
KH Hong, SA Yoo, SS Kang, JJ Choi, WU Kim, CS Cho
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Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma
Y Asano, H Ihn, M Jinnin, Y Mimura, K Tamaki
Journal of Investigative Dermatology 2006
Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts
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Scleroderma-like remodeling induced by type V collagen
MC Bezerra, WR Teodoro, CC Oliveira, AP Velosa, LT Ogido, G Gauditano, ER Parra, VL Capelozzi, NH Yoshinari
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Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
Y Wang, PS Fan, B Kahaleh
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Constitutively phosphorylated Smad3 interacts with Sp1 and p300 in scleroderma fibroblasts
H Ihn, K Yamane, Y Asano, M Jinnin, K Tamaki
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Classification analysis of the transcriptosome of nonlesional cultured dermal fibroblasts from systemic sclerosis patients with early disease
FK Tan, BA Hildebrand, MS Lester, DN Stivers, S Pounds, X Zhou, DD Wallis, DM Milewicz, JD Reveille, MD Mayes, L Jin, FC Arnett
Arthritis & Rheumatism 2005
Quantitative echographic analysis of photochemotherapy on systemic sclerosis skin
M Hashikabe, T Ohtsuka, S Yamazaki
Archives of Dermatological Research 2005
Impaired Smad7-Smurf-mediated negative regulation of transforming growth factor (TGF)-beta signaling in scleroderma fibroblasts
Yoshihide ASANO, Hironobu IHN, Kenichi YAMANE, Masahide Kubo, Kunihiko TAMAKI
Journal of Clinical Investigation 2004
Increased Expression Levels of Integrin αvβ5 on Scleroderma Fibroblasts
Y Asano, H Ihn, K Yamane, M Kubo, K Tamaki
The American Journal of Pathology 2004
Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts
Y Asano, H Ihn, K Yamane, M Kubo, K Tamaki
The American Journal of Pathology 2004
A modified model of graft-versus-host-induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease
MC Ruzek, S Jha, S Ledbetter, SM Richards, RD Garman
Arthritis & Rheumatism 2004
Phosphatidylinositol 3-Kinase Is Involved in α2(I) Collagen Gene Expression in Normal and Scleroderma Fibroblasts
Y Asano, H Ihn, K Yamane, M Jinnin, Y Mimura, K Tamaki
Journal of immunology (Baltimore, Md. : 1950) 2004
Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts
Y Mori, SJ Chen, J Varga
Arthritis & Rheumatism 2003
Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin
M Kubo, J Czuwara-Ladykowska, O Moussa, M Markiewicz, E Smith, RM Silver, S Jablonska, M Blaszczyk, DK Watson, M Trojanowska
The American Journal of Pathology 2003
Systemic sclerosis: the susceptible host (genetics and environment)
FK Tan
Rheumatic Disease Clinics of North America 2003
Sustained Activation of Fibroblast Transforming Growth Factor-β/Smad Signaling in a Murine Model of Scleroderma
S Takagawa, G Lakos, Y Mori, T Yamamoto, K Nishioka, J Varga
Journal of Investigative Dermatology 2003
Role of Hypolipidemic Drug Clofibrate in Altering Iron Regulatory Proteins IRP1 and IRP2 Activities and Hepatic Iron Metabolism in Rats Fed a Low-Iron Diet
HL Huang, NS Shaw
Toxicology and Applied Pharmacology 2002
Increased transcriptional activities of transforming growth factor ? receptors in scleroderma fibroblasts
K Yamane, H Ihn, M Kubo, K Tamaki
Arthritis & Rheumatism 2002
Scleroderma and Smads: Dysfunctional Smad family dynamics culminating in fibrosis
J Varga
Arthritis & Rheumatism 2002
Blockade of endogenous transforming growth factor ? signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor ? receptors
H Ihn, K Yamane, M Kubo, K Tamaki
Arthritis & Rheumatism 2001
Blocking Sp1 Transcription Factor Broadly Inhibits Extracellular Matrix Gene Expression In Vitro and In Vivo: Implications for the Treatment of Tissue Fibrosis
F Verrecchia, J Rossert, A Mauviel
Journal of Investigative Dermatology 2001
Senescent Expression of Genes Coding Collagens, Collagen-Degrading Metalloproteinases, and Tissue Inhibitors of Metalloproteinases in Rat Vocal Folds: Comparison With Skin and Lungs
H Ding, SD Gray
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2001
Alterations in the regulation of expression of the αl(I) collagen gene (COL1A1) in systemic sclerosis (scleroderma)
SA Jimenez, B Saitta
Springer Seminars in Immunopathology 2000
Increased phosphorylation of transcription factor Sp1 in scleroderma fibroblasts: Association with increased expression of the type I collagen gene
H Ihn, K Tamaki
Arthritis & Rheumatism 2000
Interactions of fibroblasts with the extracellular matrix: implications for the understanding of fibrosis
B Eckes, D Kessler, M Aumailley, T Krieg
Springer Seminars in Immunopathology 2000
Analysis of dendritic cell populations using a revised histological staging of morphoea
TK Gilmour, B Wilkinson, SN Breit, S Kossard
British Journal of Dermatology 2000
Genetic factors in the etiology of systemic sclerosis and Raynaud phenomenon
FK Tan, FC Arnett
Current Opinion in Rheumatology 2000
Tissue-specific expression and long-term deposition of human collagen VII in the skin of transgenic mice: implications for gene therapy
E Sat, KH Leung, L Bruckner-Tuderman, KS Cheah
Gene Therapy 2000
Fibroblast expression of collagen integrin receptors alpha1beta1 and alpha2beta1 is not changed in systemic scleroderma
Herzhoff, Sollberg, Huerkamp, Krieg, Eckes
British Journal of Dermatology 1999
Interactions of fibroblasts with the extracellular matrix: implications for the understanding of fibrosis.
Eckes B, Kessler D, Aumailley M, Krieg T
Springer Seminars in Immunopathology 1999
Increased Expression of Heat-Shock Protein 47 is Associated with Overproduction of Type I Procollagen in Systemic Sclerosis Skin Fibroblasts
K Kuroda, R Tsukifuji, H Shinkai
Journal of Investigative Dermatology 1998
Collagen type XVI expression is modulated by basic fibroblast growth factor and transforming growth factor-β
S Grässel, EM Tan, R Timpl, ML Chu
FEBS Letters 1998
Increased Expression of TGF-β Receptors by Scleroderma Fibroblasts: Evidence for Contribution of Autocrine TGF-β Signaling to Scleroderma Phenotype
T Kawakami, H Ihn, W Xu, E Smith, C LeRoy, M Trojanowska
Journal of Investigative Dermatology 1998
Transforming growth factor βs and wound healing
S O'Kane, MW Ferguson
The International Journal of Biochemistry & Cell Biology 1997
Ultraviolet A Irradiation Upregulates Type VII Collagen Expression in Human Dermal Fibroblasts
M Chen, MJ Petersen, HL Li, XY Cai, EA O'Toole, DT Woodley
Journal of Investigative Dermatology 1997
Dysregulated expression of transforming growth factor β and its type-I and type-II receptors in basal-cell carcinoma
M Furue, M Kato, K Nakamura, K Nashiro, K Kikuchi, H Okochi, K Miyazono, K Tamaki
International Journal of Cancer 1997
Regulation of interleukin-4 on collagen gene expression by systemic sclerosis fibroblasts in culture
KS Lee, YJ Ro, YW Ryoo, HJ Kwon, JY Song
Journal of Dermatological Science 1996
Imbalance of pro- and anti-inflammatory cytokines in pulmonary sarcoidosis
J Müller-Quernheim
Mediators of Inflammation 1996
PATHOGENESIS OF SCLERODERMA
SA Jimenez, E Hitraya, J Varga
Rheumatic Disease Clinics of North America 1996
IMMUNOPATHOGENESIS OF SYSTEMIC SCLEROSIS
B White
Rheumatic Disease Clinics of North America 1996
Regulation of Connective Tissue Synthesis in Systemic Sclerosis
J Varga, RI Bashey
International Reviews of Immunology 1995
TGFβ Promotes the Basal Phenotype of Epidermal Keratinocytes: Transcriptional Induction of K#5 and K#14 Keratin Genes
CK Jiang, M Tomic-Canic, DJ Lucas, M Simon, M Blumenberg
Growth Factors 1995
Connective tissue alterations in systemic sclerosis
J Varga, L Rudnicka, J Uitto
Clinics in Dermatology 1994
Rheumatology
RA Asherson, R Cervera, DP D'Cruz, GR Hughes
Postgraduate medical journal 1991

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