Citations to this article

Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway.
I Y Gluzman, … , K L Duffin, D E Goldberg
I Y Gluzman, … , K L Duffin, D E Goldberg
Published April 1, 1994
Citation Information: J Clin Invest. 1994;93(4):1602-1608. https://doi.org/10.1172/JCI117140.
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Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway.

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I Y Gluzman, S E Francis, A Oksman, C E Smith, K L Duffin, D E Goldberg

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Novel and Potent Anti-malarial Agents
KM Brinner, JM Kim, H Habashita, IY Gluzman, DE Goldberg, JA Ellman 		Bioorganic & Medicinal Chemistry 2002
Interference with Heme Binding to Histidine-Rich Protein-2 as an Antimalarial Strategy
CY Choi, EL Schneider, JM Kim, IY Gluzman, DE Goldberg, JA Ellman, MA Marletta 		Chemistry & Biology 2002
Activity and inhibition of plasmepsin IV, a new aspartic proteinase from the malaria parasite, Plasmodium falciparum
DM Wyatt, C Berry 		FEBS Letters 2002
Active Site Contribution to Specificity of the Aspartic Proteases Plasmepsins I and II
P Siripurkpong, J Yuvaniyama, P Wilairat, DE Goldberg 		The Journal of biological chemistry 2002
Peptides for the New Millennium
GB Fields, JP Tam, G Barany 		2002
Biopolymers Online: Biology • Chemistry • Biotechnology • Applications
A Steinbüchel 		2002
Analysis of antimalarial synergy between bestatin and endoprotease inhibitors using statistical response-surface modelling
CS Gavigan, SG Machado, JP Dalton, A Bell 		Antimicrobial agents and chemotherapy 2001
Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3
PS Sijwali, BR Shenai, J Gut, A Singh, PJ Rosenthal 		Biochemical Journal 2001
The role of aminopeptidases in haemoglobin degradation in Plasmodium falciparum-infected erythrocytes
CS Gavigan, JP Dalton, A Bell 		Molecular and Biochemical Parasitology 2001
Computer Modeling of Small Heat-Shock Metalloprotease of the Human Malaria Parasite <i>Plasmodium vivax</i>
V Kothekar, S Shankar, S Lomash, YD Sharma 		Journal of Biomolecular Structure and Dynamics 2001
Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets
GH Coombs, DE Goldberg, M Klemba, C Berry, J Kay, JC Mottram 		Trends in Parasitology 2001
Hemoglobin-degrading, Aspartic Proteases of Blood-feeding Parasites: SUBSTRATE SPECIFICITY REVEALED BY HOMOLOGY MODELS
RI Brinkworth, P Prociv, A Loukas, PJ Brindley 		The Journal of biological chemistry 2001
Analysis of Amide Bond Formation with an α-Hydroxy-β-amino Acid Derivative, 3-Amino-2-hydroxy-4-phenylbutanoic Acid, as an Acyl Component: Byproduction of Homobislactone
Y Hayashi, Y Kinoshita, K Hidaka, A Kiso, H Uchibori, T Kimura, Y Kiso 		The Journal of Organic Chemistry 2001
New Class of Small Nonpeptidyl Compounds Blocks Plasmodium falciparum Development In Vitro by Inhibiting Plasmepsins
S Jiang, ST Prigge, L Wei, Y Gao, TH Hudson, L Gerena, JB Dame, DE Kyle 		Antimicrobial agents and chemotherapy 2001
A cysteine protease activity from Plasmodium falciparum cleaves human erythrocyte ankyrin
P Raphael, Y Takakuwa, S Manno, SC Liu, AH Chishti, M Hanspal 		Molecular and Biochemical Parasitology 2000
Heme Metabolism of Plasmodium Is a Major Antimalarial Target
G Padmanaban, PN Rangarajan 		Biochemical and Biophysical Research Communications 2000
Characterization of Native and Recombinant Falcipain-2, a Principal Trophozoite Cysteine Protease and Essential Hemoglobinase of Plasmodium falciparum
BR Shenai, PS Sijwali, A Singh, PJ Rosenthal 		The Journal of biological chemistry 2000
The structure of malaria pigment β-haematin
S Pagola, PW Stephens, DS Bohle, AD Kosar, SK Madsen 		Nature 2000
Metalloprotease Activity in a Small Heat Shock Protein of the Human Malaria Parasite Plasmodium vivax
WA Petri, JM Fakruddin, S Biswas, YD Sharma 		Infection and immunity 2000
Kinetics of inhibition of glutathione-mediated degradation of ferriprotoporphyrin IX by antimalarial drugs
O Famin 		Biochemical Pharmacology 1999
An Antiviral Mechanism of Nitric Oxide
M Saura, C Zaragoza, A McMillan, RA Quick, C Hohenadl, JM Lowenstein, CJ Lowenstein 		Immunity 1999
Active site specificity of plasmepsin II
J Westling, P Cipullo, SH Hung, H Saft, JB Dame, BM Dunn 		Protein science : a publication of the Protein Society 1999
Phenotypic reversal of the btn1 defects in yeast by chloroquine: a yeast model for Batten disease
DA Pearce, CJ Carr, B Das, F Sherman 		Proceedings of the National Academy of Sciences 1999
An Overview of Chemotherapeutic Targets for Antimalarial Drug Discovery
PL Olliaro, Y Yuthavong 		Pharmacology & Therapeutics 1999
The fate of ferriprotorphyrin IX in malaria infected erythrocytes in conjunction with the mode of action of antimalarial drugs
J Zhang, M Krugliak, H Ginsburg 		Molecular and Biochemical Parasitology 1999
Novel ways to prevent proteolysis — prophytepsin and proplasmepsin II
NK Bernstein, MN James 		Current Opinion in Structural Biology 1999
Malaria parasite metabolism in sickle cells
AU Orjih 		European Journal of Haematology 1999
Proteases of Infectious Agents
C Berry 		Proteases of Infectious Agents 1999
Naturally-occurring and recombinant forms of the aspartic proteinases plasmepsins I and II from the human malaria parasite Plasmodium falciparum
L Tyas, I Gluzman, RP Moon, K Rupp, J Westling, RG Ridley, J Kay, DE Goldberg, C Berry 		FEBS Letters 1999
A distinct member of the aspartic proteinase gene family from the human malaria parasite Plasmodium falciparum
C Berry, MJ Humphreys, P Matharu, R Granger, P Horrocks, RP Moon, U Certa, RG Ridley, D Bur, J Kay 		FEBS Letters 1999
An antiviral mechanism of nitric oxide: inhibition of a viral protease
M Saura, C Zaragoza, A McMillan, R A Quick, C Hohenadl, J M Lowenstein, C J Lowenstein 		Immunity 1999
Cellular Uptake of Chloroquine Is Dependent on Binding to Ferriprotoporphyrin IX and Is Independent of NHE Activity in Plasmodium falciparum
PG Bray, O Janneh, KJ Raynes, M Mungthin, H Ginsburg, SA Ward 		The Journal of Cell Biology 1999
Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite
AV Pandey, BL Tekwani, RL Singh, VS Chauhan 		The Journal of biological chemistry 1999
Plasmepsin II, an Acidic Hemoglobinase from the Plasmodium falciparum Food Vacuole, Is Active at Neutral pH on the Host Erythrocyte Membrane Skeleton
SL Bonniec, C Deregnaucourt, V Redeker, R Banerjee, P Grellier, DE Goldberg, J Schrével 		The Journal of biological chemistry 1999
Identification and Characterization of Falcilysin, a Metallopeptidase Involved in Hemoglobin Catabolism within the Malaria Parasite Plasmodium falciparum
KK Eggleson, KL Duffin, DE Goldberg 		The Journal of biological chemistry 1999
An Antiviral Mechanism of Nitric Oxide: Inhibition of a Viral Protease
Saura M, Zaragoza C, McMillan A, Quick RA, Hohenadl C, Lowenstein JM, Lowenstein CJ 		Immunity 1999
Central role of hemoglobin degradation in mechanisms of action of 4-aminoquinolines, quinoline methanols, and phenanthrene methanols
M Mungthin, PG Bray, RG Ridley, SA Ward 		Antimicrobial agents and chemotherapy 1998
Antimalarial synergy of cysteine and aspartic protease inhibitors
A Semenov, JE Olson, PJ Rosenthal 		Antimicrobial agents and chemotherapy 1998
Proteases of malaria parasites: new targets for chemotherapy
PJ Rosenthal 		Emerging infectious diseases 1998
4-Aminoquinolines—Past, present, and future; A chemical perspective
PM O'Neill, PG Bray, SR Hawley, SA Ward, BK Park 		Pharmacology & Therapeutics 1998
Uptake of an antiplasmodial protease inhibitor into Plasmodium falciparum-infected human erythrocytes via a parasite-induced pathway
KJ Saliba, K Kirk 		Molecular and Biochemical Parasitology 1998
Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D
CD Carroll, TO Johnson, S Tao, G Lauri, M Orlowski, IY Gluzman, DE Goldberg, RE Dolle 		Bioorganic & Medicinal Chemistry Letters 1998
Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library
CD Carroll, H Patel, TO Johnson, T Guo, M Orlowski, ZM He, CL Cavallaro, J Guo, A Oksman, IY Gluzman, J Connelly, D Chelsky, DE Goldberg, RE Dolle 		Bioorganic & Medicinal Chemistry Letters 1998
Acidic calcium pools in intraerythrocytic malaria parasites
CR Garcia, SE Ann, ES Tavares, AR Dluzewski, WT Mason, FB Paiva 		European Journal of Cell Biology 1998
Enzyme Handbook 16
D Schomburg, D Stephan 		1998
Access to Hematin: The Basis of Chloroquine Resistance
PG Bray, M Mungthin, RG Ridley, SA Ward 		Molecular pharmacology 1998
Transgenic Mice Expressing Human Fetal Globin Are Protected From Malaria by a Novel Mechanism
HL Shear, L Grinberg, J Gilman, ME Fabry, G Stamatoyannopoulos, DE Goldberg, RL Nagel 		Blood 1998
Haemoglobin Degradation and Haem Polymerization as Antimalarial Drug Targets
RG Ridley 		Journal of Pharmacy and Pharmacology 1997
HEMOGLOBIN METABOLISM IN THE MALARIA PARASITEPLASMODIUM FALCIPARUM
SE Francis, DJ Sullivan, DE Goldberg 		Annual Review of Microbiology 1997
Generation of hemoglobin peptides in the acidic digestive vacuole of Plasmodium falciparum implicates peptide transport in amino acid production
KA Kolakovich, IY Gluzman, KL Duffin, DE Goldberg 		Molecular and Biochemical Parasitology 1997
New Targets for Antimalarial Drug Discovery
P Olliaro, D Wirth 		Journal of Pharmacy and Pharmacology 1997
Expression and Characterisation of Plasmepsin I from Plasmodium falciparum
RP Moon, L Tyas, U Certa, K Rupp, D Bur, C Jacquet, H Matile, H Loetscher, F Grueninger-Leitch, J Kay, BM Dunn, C Berry, RG Ridley 		European Journal of Biochemistry 1997
Plasmodium falciparum, P. vivax,andP. malariae:A Comparison of the Active Site Properties of Plasmepsins Cloned and Expressed from Three Different Species of the Malaria Parasite
J Westling, CA Yowell, P Majer, JW Erickson, JB Dame, BM Dunn 		Experimental Parasitology 1997
New targets for antimalarial therapy: The plasmepsins, malaria parasite aspartic proteinases
C Berry 		Biochemical Education 1997
Haematin (haem) polymerization and its inhibition by quinoline antimalarials
RG Ridley, A Dorn, SR Vippagunta, JL Vennerstrom 		Annals of Tropical Medicine and Parasitology 1997
Biosynthesis and Maturation of the Malaria Aspartic Hemoglobinases Plasmepsins I and II
SE Francis, R Banerjee, DE Goldberg 		The Journal of biological chemistry 1997
Probing the Chloroquine Resistance Locus of Plasmodium falciparum with a Novel Class of Multidentate Metal(III) Coordination Complexes
DE Goldberg, V Sharma, A Oksman, IY Gluzman, TE Wellems, D Piwnica-Worms 		The Journal of biological chemistry 1997
Identification of hemoglobin degradation products in Plasmodium falciparum
S Kamchonwongpaisan, E Samoff, SR Meshnick 		Molecular and Biochemical Parasitology 1997
Characterization of the Products of the Heme Detoxification Pathway in Malarial Late Trophozoites by X-ray Diffraction
DS Bohle, RE Dinnebier, SK Madsen, PW Stephens 		The Journal of biological chemistry 1997
Analytical Parasitology
MT Rogan 		1997
Interaction between oxidized hemoglobin and the cell membrane: A common basis for severalfalciparum malaria-linked genetic traits
G Destro-Bisol, B Giardina, B Sansonetti, G Spedini 		American Journal of Physical Anthropology 1996
Hemoglobin catabolism and iron utilization by malaria parasites
P Rosenthal 		Molecular and Biochemical Parasitology 1996
Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors
PJ Rosenthal, JE Olson, GK Lee, JT Palmer, JL Klaus, D Rasnick 		Antimicrobial agents and chemotherapy 1996
Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum
AM Silva, AY Lee, SV Gulnik, P Maier, J Collins, TN Bhat, PJ Collins, RE Cachau, KE Luker, IY Gluzman, SE Francis, A Oksman, DE Goldberg, JW Erickson 		Proceedings of the National Academy of Sciences 1996
Conservation of key amino acids among the cysteine proteinases of multiple malarial species
PJ Rosenthal 		Molecular and Biochemical Parasitology 1996
Kinetic analysis of plasmepsins I and II, aspartic proteases of the Plasmodium falciparum digestive vacuole
KE Luker, SE Francis, IY Gluzman, DE Goldberg 		Molecular and Biochemical Parasitology 1996
Characterization of native falcipain, an enzyme involved in Plasmodium falciparum hemoglobin degradation
S Francis 		Molecular and Biochemical Parasitology 1996
Cathepsin B of Schistosoma mansoni: PURIFICATION AND ACTIVATION OF THE RECOMBINANT PROENZYME SECRETED BY SACCHAROMYCES CEREVISIAE
G Lipps, R Füllkrug, E Beck 		The Journal of biological chemistry 1996
Inhibition of Hemozoin Formation in Plasmodium falciparum Trophozoite Extracts by Heme Analogs: Possible Implication in the Resistance to Malaria Conferred by the β-Thalassemia Trait
JA Martiney, A Cerami, AF Slater 		Molecular Medicine 1996
Intracellular Protein Catabolism
K Suzuki, JS Bond 		1996
Plasmodium Hemozoin Formation Mediated by Histidine-Rich Proteins
DJ Sullivan, IY Gluzman, DE Goldberg 		Science 1996
Pharmacokinetics of Quinine, Chloroquine and Amodiaquine: Clinical Implications
S Krishna, NJ White 		Clinical Pharmacokinetics 1996
The Plasmodium digestive Vacuole: Metabolic Headquarters and Choice Drug Target
PL Olliaro, DE Goldberg 		Parasitology Today 1995
Functional expression of falcipain, a Plasmodium falciparum cysteine proteinase, supports its role as a malarial hemoglobinase
F Salas, J Fichmann, GK Lee, MD Scott, PJ Rosenthal 		Infection and immunity 1995
Biochemistry and Molecular Biology of Parasites
JF Dubremetz, JH McKerrow 		Biochemistry and Molecular Biology of Parasites 1995
Advances in Drug Research
CL Crespi 		Advances in Drug Research 1995
Verapamil Reversal of Chloroquine Resistance in the Malaria Parasite Plasmodium falciparum Is Specific for Resistant Parasites and Independent of the Weak Base Effect
JA Martiney, A Cerami, AF Slater 		The Journal of biological chemistry 1995
Aspartic Proteinases
K Takahashi 		1995
Digestion and indigestion in malaria parasites
W Trager 		Journal of Clinical Investigation 1994
High level expression and characterisation of Plasmepsin II, an aspartic proteinase from Plasmodium falciparum
J Hill, L Tyas, LH Phylip, J Kay, BM Dunn, C Berry 		FEBS Letters 1994

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