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Citations to this article

Cyclosporin A inhibits CD40 ligand expression in T lymphocytes.
R Fuleihan, … , W Harmon, R S Geha
R Fuleihan, … , W Harmon, R S Geha
Published March 1, 1994
Citation Information: J Clin Invest. 1994;93(3):1315-1320. https://doi.org/10.1172/JCI117089.
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Research Article Article has an altmetric score of 3

Cyclosporin A inhibits CD40 ligand expression in T lymphocytes.

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Abstract

The ligand for CD40 is expressed on activated T lymphocytes and delivers contact-dependent activation signals to B lymphocytes. The mechanisms regulating CD40 ligand gene expression are largely unknown. Optimal expression of CD40 ligand required activation of protein kinase C and a rise in intracellular calcium concentration. CD40 ligand expression was inhibited by pretreatment of T cells with cyclosporin A. Cyclosporin A analogues inhibited CD40 ligand expression with a potency mirroring the ability of each compound to inhibit calcineurin activity, indicating that calcineurin plays a key role in CD40 ligand gene expression. Cyclosporin A inhibited IL-4-driven CD40 ligand-dependent IgE isotype switching in PBMC but did not inhibit IgE synthesis induced by CD40 mAb plus IL-4. PBMC derived from transplant patients receiving cyclosporin A failed to express CD40 ligand upon stimulation. These results suggest that patients receiving cyclosporin A may be deficient in CD40 ligand-dependent T cell help.

Authors

R Fuleihan, N Ramesh, A Horner, D Ahern, P J Belshaw, D G Alberg, I Stamenkovic, W Harmon, R S Geha

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Year: 2022 2020 2018 2017 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1988 Total
Citations: 1 1 3 4 1 3 2 4 1 1 3 2 4 3 3 8 5 8 11 7 9 8 8 5 4 1 110
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Citations to this article in year 2012 (2)

Title and authors Publication Year
Effects of Epstein-Barr virus infection on the development of multiple myeloma after liver transplantation
YW Zhang, HW Zhao, X He, SW Zheng, TH Wang, DL Yan, JF Sun, X Lu, JF Wen, WY Lau
Science China Life Sciences 2012
Differential modulation by delta9-tetrahydrocannabinol (∆9)-THC) of CD40 ligand (CD40L) expression in activated mouse splenic CD4+ T cells
T Ngaotepprutaram, BL Kaplan, RB Crawford, NE Kaminski
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012

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Referenced in 5 patents
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