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Research Article Free access | 10.1172/JCI117083

Angiotensinogen as a risk factor for essential hypertension in Japan.

A Hata, C Namikawa, M Sasaki, K Sato, T Nakamura, K Tamura, and J M Lalouel

Department of Biochemistry, Nagoya City University Medical School, Japan.

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Department of Biochemistry, Nagoya City University Medical School, Japan.

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Department of Biochemistry, Nagoya City University Medical School, Japan.

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Department of Biochemistry, Nagoya City University Medical School, Japan.

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Department of Biochemistry, Nagoya City University Medical School, Japan.

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Department of Biochemistry, Nagoya City University Medical School, Japan.

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Department of Biochemistry, Nagoya City University Medical School, Japan.

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Published March 1, 1994 - More info

Published in Volume 93, Issue 3 on March 1, 1994
J Clin Invest. 1994;93(3):1285–1287. https://doi.org/10.1172/JCI117083.
© 1994 The American Society for Clinical Investigation
Published March 1, 1994 - Version history
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Abstract

A common molecular variant of angiotensinogen (AGT), the precursor of the potent vasoactive hormone angiotensin II, has been incriminated as a marker for a genetic predisposition to essential hypertension in Caucasians (Jeunemaitre, X., F. Soubrier, Y. V. Kotelevtsev, R. P. Lifton, C. S. Williams, A. Charru, S. C. Hunt, P. N. Hopkins, R. R. Williams, J. M. Lalouel, and P. Corvol. 1992. Cell. 71:169-180). We now show that the same variant, T235, is associated with essential hypertension in Japanese patients. The observation of this association in a distinct, ethnically homogeneous population further substantiates an involvement of angiotensinogen in the pathogenesis of essential hypertension and has physiological, epidemiological, and evolutionary implications.

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