Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.
M Clerici, … , R L Coffman, G M Shearer
M Clerici, … , R L Coffman, G M Shearer
Published February 1, 1994
Citation Information: J Clin Invest. 1994;93(2):768-775. https://doi.org/10.1172/JCI117031.
View: Text | PDF
Research Article Article has an altmetric score of 3

Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.

  • Text
  • PDF
Abstract

The loss of T helper cell (TH) function in asymptomatic HIV type 1-infected individuals occurs before the decline in CD4+ T cells. At least part of the loss in TH function results from changes in immunoregulatory cytokine profiles. To investigate the role of IL-10 in such dysregulation, we tested whether: (a) expression of IL-10-specific mRNA would be upregulated in PBMC from asymptomatic, HIV-infected (HIV+) individuals; (b) PBMC from these same individuals would produce increased levels of IL-10 when stimulated in vitro with phytohemagglutinin; and (c) defective antigen-specific TH function could be restored by anti-IL-10 antibody. We observed that IL-10-specific mRNA was marginally upregulated, and increased levels of IL-10 were produced by PBMC from HIV+ individuals compared with PBMC from uninfected individuals. Those individuals whose TH function was more severely compromised produced higher levels of IL-10. Additionally, defective antigen-specific TH function in vitro could be reversed by anti-IL-10 antibody, including the response to HIV envelope synthetic peptides. Furthermore, the antigen-specific TH responses of HIV-uninfected PBMC could be reduced with IL-10, a process reversed by anti-IL-10. These results confirm that the early loss of TH function in HIV+ individuals is due at least in part to cytokine-induced immune dysregulation, and support the hypothesis of a switch from a predominant type 1 state to a predominant type 2 condition in HIV infection.

Authors

M Clerici, T A Wynn, J A Berzofsky, S P Blatt, C W Hendrix, A Sher, R L Coffman, G M Shearer

×

Total citations by year

Year: 2024 2023 2022 2021 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1990 1987 Total
Citations: 1 1 2 1 1 3 2 6 6 11 16 7 8 18 9 7 11 6 6 4 2 13 13 9 19 26 31 23 21 26 2 1 2 314
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2010 (18)

Title and authors Publication Year
Negative Co-Receptors and Ligands
R Ahmed, T Honjo
2010
Negative Co-Receptors and Ligands
R Ahmed, T Honjo
2010
Negative Co-Receptors and Ligands
R Ahmed, T Honjo
2010
Negative Co-Receptors and Ligands
R Ahmed, T Honjo
2010
Negative Co-Receptors and Ligands
R Ahmed, T Honjo
2010
Negative Co-Receptors and Ligands
R Ahmed, T Honjo
2010
99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: Viruses, autoimmunity and immunoregulation
CM Filippi, MG von Herrath
Clinical & Experimental Immunology 2010
IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection
DG Brooks, KB Walsh, H Elsaesser, MB Oldstone
Proceedings of the National Academy of Sciences 2010
Features of responding T cells in cancer and chronic infection
PS Kim, R Ahmed
Current Opinion in Immunology 2010
T-cell exhaustion: characteristics, causes and conversion
JS Yi, MA Cox, AJ Zajac
Immunology 2010
Translating insights from persistent LCMV infection into anti-HIV immunity
EB Wilson, DG Brooks
Immunologic Research 2010
Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
EA Said, FP Dupuy, L Trautmann, Y Zhang, Y Shi, M El-Far, BJ Hill, A Noto, P Ancuta, Y Peretz, SG Fonseca, JV Grevenynghe, MR Boulassel, J Bruneau, NH Shoukry, JP Routy, DC Douek, EK Haddad, RP Sekaly
Nature Medicine 2010
Beyond IL-17: new cytokines in the pathogenesis of HIV infection
M Clerici
Current Opinion in HIV and AIDS 2010
Interleukin-10 repletion suppresses pro-inflammatory cytokines and decreases liver pathology without altering viral replication in murine cytomegalovirus (MCMV)-infected IL-10 knockout mice
YJ Tang-Feldman, GR Lochhead, SR Lochhead, C Yu, C Pomeroy
Inflammation Research 2010
Impact of γ-chain cytokines on T cell homeostasis in HIV-1 infection: therapeutic implications
ML Gougeon, F Chiodi
Journal of Internal Medicine 2010
How chronic viral infections impact on antigen-specific T-cell responses
H Frebel, K Richter, A Oxenius
European Journal of Immunology 2010
Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins
JK Wong, GR Campbell, SA Spector
The Journal of biological chemistry 2010
Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS.
Sezgin E, Jabs DA, Hendrickson SL, Van Natta M, Zdanov A, Lewis RA, Smith MW, Troyer JL, O'Brien SJ
The Journal of Infectious Diseases 2010

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 4 patents
39 readers on Mendeley
See more details