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F N Ziyadeh, … , M Ericksen, G Wolf
Published February 1, 1994
Citation Information: J Clin Invest. 1994;93(2):536-542. https://doi.org/10.1172/JCI117004.
Citation Information: J Clin Invest. 1994;93(2):536-542. https://doi.org/10.1172/JCI117004.
Abstract
Previous investigations have demonstrated that growing mesangial cells in high glucose concentration stimulates extracellular matrix synthesis and also increases the expression of TGF-beta. We tested whether the stimulation of extracellular matrix production is mediated by autocrine activation of TGF-beta, a known prosclerotic cytokine. Addition of neutralizing anti-TGF-beta antibody, but not normal rabbit IgG, significantly reduced the high glucose-stimulated incorporation of 3[H]proline. Denaturing SDS-PAGE revealed that mainly collagen types I and IV were stimulated by high (450 mg/dl) D-glucose. This high glucose-mediated increase in collagen synthesis was reduced by the anti-TGF-beta antibody. Treatment of mesangial cells grown in normal (100 mg/dl) D-glucose with 2 ng/ml recombinant TGF-beta 1 mimicked the effects of high glucose. Furthermore, the anti-TGF-beta antibody significantly reduced the increase in mRNA levels encoding alpha 2(I) and alpha 1(IV) collagens induced by high glucose. Thus, the high glucose-stimulated increase of collagen production in mesangial cells is mediated, at least in part, by autocrine TGF-beta activation. We postulate that the interception of the glomerular activity of TGF-beta may be an effective intervention in the management of diabetic nephropathy.
Authors
F N Ziyadeh, K Sharma, M Ericksen, G Wolf
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Type VIII Collagen Modulates TGF-β1-induced Proliferation of Mesangial Cells
I Loeffler, U Hopfer, D Koczan, G Wolf |
Journal of the American Society of Nephrology : JASN | 2011 |
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The Renin Inhibitor Aliskiren Attenuates High-Glucose Induced Extracellular Matrix Synthesis and Prevents Apoptosis in Cultured Podocytes
LM Phillips, Y Wang, T Dai, DL Feldman, J LaPage, SG Adler |
Nephron Experimental Nephrology | 2011 |
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Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes
R Kodera, K Shikata, HU Kataoka, T Takatsuka, S Miyamoto, M Sasaki, N Kajitani, S Nishishita, K Sarai, D Hirota, C Sato, D Ogawa, H Makino |
Diabetologia | 2011 |
|
Knockout of Toll-Like Receptor-2 Attenuates Both the Proinflammatory State of Diabetes and Incipient Diabetic Nephropathy
S Devaraj, P Tobias, BS Kasinath, R Ramsamooj, A Afify, I Jialal |
Arteriosclerosis, thrombosis, and vascular biology | 2011 |
|
The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy
CE Hills, PE Squires |
Cytokine & Growth Factor Reviews | 2011 |
|
Everolimus vs. rapamycin for treating diabetic nephropathy in diabetic mouse model
L Cheng, J Chen, X Mao |
Journal of Huazhong University of Science and Technology [Medical Sciences] | 2011 |
|
Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes
H Zhou, Y Li, M Wang, L Zhang, B Guo, Z Zhao, F Meng, Y Deng, R Wang |
Acta Pharmacologica Sinica | 2011 |
|
Resveratrol ameliorates early diabetic nephropathy associated with suppression of augmented TGF-β/smad and ERK1/2 signaling in streptozotocin-induced diabetic rats
KH Chen, CC Hung, HH Hsu, YH Jing, CW Yang, JK Chen |
Chemico-Biological Interactions | 2011 |
|
L-carnosine inhibits high-glucose-mediated matrix accumulation in human mesangial cells by interfering with TGF- production and signalling
H Koppel, E Riedl, M Braunagel, S Sauerhoefer, S Ehnert, P Godoy, P Sternik, S Dooley, BA Yard |
Nephrology Dialysis Transplantation | 2011 |
|
Long-term diabetic complications may be ameliorated by targeting Rho kinase
H Zhou, Y Li |
Diabetes/Metabolism Research and Reviews | 2011 |
|
Effects of Beraprost Sodium, a Prostaglandin I2 Analog, on High Glucose-Induced Proliferation and Oxidative Stress in a Rat Glomerular Mesangial Cell Line
LY Zhang, JJ Zou, ZM Liu |
Pharmacology | 2011 |
|
Uric Acid as a Mediator of Diabetic Nephropathy
DI Jalal, DM Maahs, P Hovind, T Nakagawa |
Seminars in Nephrology | 2011 |
|
Long-term renal changes in the liver-specific glucokinase knockout mouse: implications for renal disease in maturity-onset diabetes of the young 2
Y Gu, Y Mao, H Li, S Zhao, Y Yang, H Gao, J Yu, X Zhang, DM Irwin, G Niu, H Tan |
Translational Research | 2011 |
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Inhibitory Effects of Ecklonia cava Extract on High Glucose-Induced Hepatic Stellate Cell Activation
K Yokogawa, I Matsui-Yuasa, A Tamura, M Terada, A Kojima-Yuasa |
Marine drugs | 2011 |
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Jak2-Independent Activation of Stat3 by Intracellular Angiotensin II in Human Mesangial Cells
R Singh |
Journal of Signal Transduction | 2011 |
|
Cation-independent mannose 6-phosphate receptor inhibitor (PXS25) inhibits fibrosis in human proximal tubular cells by inhibiting conversion of latent to active TGF-β 1
MG Wong, U Panchapakesan, W Qi, DG Silva, XM Chen, CA Pollock |
American journal of physiology. Renal physiology | 2011 |
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Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters
Y Maeda, T Inoguchi, R Takei, F Sawada, S Sasaki, M Fujii, K Kobayashi, H Urata, A Nishiyama, R Takayanagi |
American journal of physiology. Renal physiology | 2010 |
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Abnormalities in signaling pathways in diabetic nephropathy
FC Brosius, CC Khoury, CL Buller, S Chen |
Expert Review of Endocrinology & Metabolism | 2010 |
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Diabetic microvascular complications: possible targets for improved macrovascular outcomes
JA D'Elia, G Bayliss, B Roshan, M Maski, RE Gleason, LA Weinrauch |
International journal of nephrology and renovascular disease | 2010 |
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Vascular Basement Membrane Thickening in Diabetic Retinopathy
S Roy, J Ha, K Trudeau, E Beglova |
Current Eye Research | 2010 |
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High glucose-induced apoptosis in bovine retinal pericytes is associated with transforming growth factor β and βIG-H3: βIG-H3 induces apoptosis in retinal pericytes by releasing Arg-Gly-Asp peptides
JH Han, SW Ha, IK Lee, BW Kim, JG Kim |
Clinical & Experimental Ophthalmology | 2010 |
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Regulation of transforming growth factor-β1 by insulin in prediabetic African Americans
Y Huan, S DeLoach, C Daskalakis, SR Dunn, K Sharma, B Falkner |
Kidney International | 2010 |
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Relationship between Oxidative Stress and Inflammatory Cytokines in Diabetic Nephropathy
AA Elmarakby, JC Sullivan |
Cardiovascular Therapeutics | 2010 |
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Significant Correlation Between Association of Polymorphism in Codon 10 of Transforming Growth Factor-β1 T (29) C With Type 1 Diabetes and Patients With Nephropathy Disorder
MM Jahromi, BA Millward, AG Demaine |
Journal of Interferon & Cytokine Research | 2010 |
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Andrographolide and 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata attenuate high glucose-induced fibrosis and apoptosis in murine renal mesangeal cell lines
MJ Lee, YK Rao, K Chen, YC Lee, YS Chung, YM Tzeng |
Journal of Ethnopharmacology | 2010 |
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Vitamins & Hormones
KJ Hare, FK Knop |
Vitamins & Hormones | 2010 |
|
Pediatric Urology
C Bouvattier |
Pediatric Urology | 2010 |
|
Epigenetic Histone Methylation Modulates Fibrotic Gene Expression
G Sun, MA Reddy, H Yuan, L Lanting, M Kato, R Natarajan |
Journal of the American Society of Nephrology : JASN | 2010 |
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Studies on Renal Disorders
T Miyata, KU Eckardt, M Nangaku |
2010 | |
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High Glucose Potentiates Collagen Synthesis and Bone Morphogenetic Protein-2-Induced Early Osteoblast Gene Expression in Rat Spinal Ligament Cells
H Li, LS Jiang, LY Dai |
Endocrinology | 2010 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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TGF-β and fibrosis in different organs — molecular pathway imprints
D Pohlers, J Brenmoehl, I Löffler, CK Müller, C Leipner, S Schultze-Mosgau, A Stallmach, RW Kinne, G Wolf |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2009 |
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Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist
Y Zhang, DK Deb, J Kong, G Ning, Y Wang, G Li, Y Chen, Z Zhang, S Strugnell, Y Sabbagh, C Arbeeny, YC Li |
American journal of physiology. Renal physiology | 2009 |
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Essential role of TGF-beta signaling in glucose-induced cell hypertrophy
L Wu, R Derynck |
Developmental Cell | 2009 |
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Regulation of type IV collagen alpha chains of glomerular epithelial cells in diabetic conditions
TS Ha, EJ Hong, EM Ahn, HY Ahn |
Journal of Korean Medical Science | 2009 |
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Urinary protein profiles in a rat model for diabetic complications
DM Schlatzer, JE Dazard, M Dharsee, RM Ewing, S Ilchenko, I Stewart, G Christ, MR Chance |
Molecular & cellular proteomics : MCP | 2009 |
|
Effects of genistein on secretion of extracellular matrix components and transforming growth factor beta in high-glucose-cultured rat mesangial cells
WJ Yuan, FY Jia, JZ Meng |
Journal of Artificial Organs | 2009 |
|
High ambient glucose induces angiotensin-independent AT-1 receptor activation, leading to increases in proliferation and extracellular matrix accumulation in MES-13 mesangial cells
N Yano, D Suzuki, M Endoh, TN Cao, JR Dahdah, A Tseng, JP Stabila, BG McGonnigal, JF Padbury, YT Tseng |
Biochemical Journal | 2009 |
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Genetic Diseases of the Kidney
K Ichida, M Hosoyamada, T Hosoya, H Endou |
Genetic Diseases of the Kidney | 2009 |
|
Reno-protective effects of fenugreek (Trigonella foenum greacum) during experimental diabetes
AK Shetty, PV Salimath |
e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism | 2009 |
|
Transforming growth factor-β and diabetic nephropathy
G Wolf, FN Ziyadeh |
Journal of Organ Dysfunction | 2009 |
|
Activation of renal renin-angiotensin system in upstream stimulatory factor 2 transgenic mice
L Shi, D Nikolic, S Liu, H Lu, S Wang |
American journal of physiology. Renal physiology | 2009 |
|
Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT 1 receptor antagonist
Y Zhang, DK Deb, J Kong, G Ning, Y Wang, G Li, Y Chen, Z Zhang, S Strugnell, Y Sabbagh, C Arbeeny, YC Li |
American journal of physiology. Renal physiology | 2009 |
|
Modification of Collagen IV by Glucose or Methylglyoxal Alters Distinct Mesangial Cell Functions
A Pozzi, R Zent, S Chetyrkin, C Borza, N Bulus, P Chuang, D Chen, B Hudson, P Voziyan |
Journal of the American Society of Nephrology : JASN | 2009 |
|
Diabetic kidney lesions of GIPR dn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis
N Herbach, I Schairer, A Blutke, S Kautz, A Siebert, B Göke, E Wolf, R Wanke |
American journal of physiology. Renal physiology | 2009 |
|
Rab34 and its effector munc13-2 constitute a new pathway modulating protein secretion in the cellular response to hyperglycemia
NM Goldenberg, M Silverman |
American journal of physiology. Cell physiology | 2009 |
|
Role of kidney ADP-ribosyl cyclase in diabetic nephropathy
SY Kim, KH Park, R Gul, KY Jang, UH Kim |
American journal of physiology. Renal physiology | 2009 |
|
New Insights into the Mechanisms of Fibrosis and Sclerosis in Diabetic Nephropathy
FC Brosius |
Reviews in Endocrine and Metabolic Disorders | 2008 |
|
NOX enzymes and diabetic complications
T Kakehi, C Yabe-Nishimura |
Seminars in Immunopathology | 2008 |
|
From Fibrosis to Sclerosis: Mechanisms of Glomerulosclerosis in Diabetic Nephropathy
Y Qian, E Feldman, S Pennathur, M Kretzler, FC Brosius |
Diabetes | 2008 |
|
Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan
ES Kang, BS Kim, CH Kim, GH Seo, SJ Han, SW Chun, KY Hur, CW Ahn, H Ha, M Jung, BS Cha, HC Lee |
Korean Diabetes Journal | 2008 |
|
High glucose promotes collagen synthesis by cultured cells from rat cervical posterior longitudinal ligament via transforming growth factor-β1
H Li, D Liu, CQ Zhao, LS Jiang, LY Dai |
European Spine Journal | 2008 |
|
Regulation of renal 12(S)-hydroxyeicosatetraenoic acid in diabetes by angiotensin AT1 and AT2 receptors
EM Abdel-Rahman, PM Abadir, HM Siragy |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2008 |
|
Fibrosis in diabetes complications: pathogenic mechanisms and circulating and urinary markers
CR Ban, SM Twigg |
Vascular Health and Risk Management | 2008 |
|
Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy
K Tikoo, RL Meena, DG Kabra, AB Gaikwad |
British Journal of Pharmacology | 2008 |
|
The effects of ACE inhibitor and angiotensin receptor blocker on clusterin and apoptosis in the kidney tissue of streptozotocin-diabetic rats
M Tunçdemir, M Ozturk |
Journal Of Molecular Histology | 2008 |
|
Protein kinase C beta inhibitors: a new therapeutic target for diabetic nephropathy and vascular complications
S Budhiraja, J Singh |
Fundamental & Clinical Pharmacology | 2008 |
|
Atrial natriuretic peptide attenuates high glucose-activated transforming growth factor-β, Smad and collagen synthesis in renal proximal tubular cells
CS Lo, ZH Chen, TJ Hsieh, SJ Shin |
Journal of Cellular Biochemistry | 2008 |
|
Role of Increased Penile Expression of Transforming Growth Factor-β1 and Activation of the Smad Signaling Pathway in Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats
LW Zhang, S Piao, MJ Choi, HY Shin, HR Jin, WJ Kim, SU Song, JY Han, SH Park, M Mamura, SJ Kim, JK Ryu, JK Suh |
Journal of Sexual Medicine | 2008 |
|
Second harmonic microscopy to quantify renal interstitial fibrosis and arterial remodeling
M Strupler, M Hernest, C Fligny, JL Martin, PL Tharaux, MC Schanne-Klein |
Journal of Biomedical Optics | 2008 |
|
Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
HK Usui, K Shikata, M Sasaki, H Makino |
Okayama Igakkai Zasshi (Journal of Okayama Medical Association) | 2008 |
|
The activation of NF-κB and AP-1 in peripheral blood mononuclear cells isolated from patients with diabetic nephropathy
JS Nam, MH Cho, GT Lee, JS Park, CW Ahn, BS Cha, SK Lim, KR Kim, HJ Ha, HC Lee |
Diabetes Research and Clinical Practice | 2008 |
|
Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats
ES Kang, GT Lee, BS Kim, CH Kim, GH Seo, SJ Han, KY Hur, CW Ahn, H Ha, M Jung, YS Ahn, BS Cha, HC Lee |
European Journal of Pharmacology | 2008 |
|
Renin–angiotensin system blockade in diabetic nephropathy
J Ahmad |
Diabetes and Metabolic Syndrome Clinical Research and Reviews | 2008 |
|
Salt: Its Role in Chronic Kidney Disease
S Thijssen, TM Kitzler, NW Levin |
Journal of Renal Nutrition | 2008 |
|
マクロファージスカベンジャー受容体（ＳＲ‐Ａ）は炎症を制御することにより糖尿病性腎症を抑制する
HK Usui, K Shikata, M Sasaki, H Makino |
Okayama Igakkai Zasshi (Journal of Okayama Medical Association) | 2008 |
|
Regulation of renal 12(S)-hydroxyeicosatetraenoic acid in diabetes by angiotensin AT 1 and AT 2 receptors
EM Abdel-Rahman, PM Abadir, HM Siragy |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2008 |
|
Reduced cortical renal GLUT1 expression induced by angiotensin-converting enzyme inhibition in diabetic spontaneously hypertensive rats
MS Souza, UF Machado, M Okamoto, MC Bertoluci, C Ponpermeyer, N Leguisamo, F Azambuja, MC Irigoyen, BD Schaan |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2008 |
|
High glucose activates PKC-ζ and NADPH oxidase through autocrine TGF-β 1 signaling in mesangial cells
L Xia, H Wang, S Munk, J Kwan, HJ Goldberg, IG Fantus, CI Whiteside |
American journal of physiology. Renal physiology | 2008 |
|
Transforming Growth Factor-β in Cancer Therapy, Volume II
SB Jakowlew |
2008 | |
|
Glucose Transporter 12 and Mammalian Target of Rapamycin Complex 1 Signaling: A New Target for Diabetes-Induced Renal Injury?
H Schmid, M Bertoluci, TM Coimbra |
Endocrinology | 2008 |
|
The Aging Kidney in Health and Disease
JF MachasNúñez, JS Cameron, DG Oreopoulos |
2008 | |
|
Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation
HK Usui, K Shikata, M Sasaki, S Okada, M Matsuda, Y Shikata, D Ogawa, Y Kido, R Nagase, K Yozai, S Ohga, A Tone, J Wada, M Takeya, M Takeya, S Horiuchi, T Kodama, H Makino |
Diabetes | 2007 |
|
Regulation of transforming growth factor beta in diabetic nephropathy: implications for treatment
Y Zhu, HK Usui, K Sharma |
Seminars in Nephrology | 2007 |
|
'Correction:' Serum transforming growth factor beta-1 (TGF-beta-1) levels in diabetic patients are not associated with pre-existent coronary artery disease
BD Schaan, AS Quadros, R Sarmento-Leite, GD Lucca, A Bender, M Bertoluci |
Cardiovascular Diabetology | 2007 |
|
Advanced glycation end products decrease mesangial cell MMP-7: A role in matrix accumulation in diabetic nephropathy?
SV McLennan, DJ Kelly, M Schache, M Waltham, V Dy, RG Langham, DK Yue, RE Gilbert |
Kidney International | 2007 |
|
Navigating pathways affecting type 1 diabetic kidney disease
L Pasquali, M Trucco, S Ringquist |
Pediatric Diabetes | 2007 |
|
The role of protein kinase C activation in diabetic nephropathy
H Noh, GL King |
Kidney International | 2007 |
|
Activation of NF-κB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy
J Nam, MH Cho, JS Park, GT Lee, HJ Kim, ES Kang, YM Lee, CW Ahn, BS Cha, EJ Lee, SK Lim, KR Kim, HJ Ha, HC Lee |
The Journal of Korean Diabetes Association | 2007 |
|
Effects of Troglitazone on the Expression of VEGF and TGF-β in Cultured Rat Mesangial Cells
DL Kim, NH Kim, DS Choi |
The Journal of Korean Diabetes Association | 2007 |
|
Glucose modulates handling of apoptotic cells by mesangial cells: involvement of TGF-β1
TK Khera, J Martin, SG Riley, R Steadman, AO Phillips |
Laboratory Investigation | 2007 |
|
Therapeutic potential of TGF-β inhibition in chronic renal failure
E Gagliardini, A Benigni |
Expert Opinion on Biological Therapy | 2007 |
|
Effects of long-term elevated glucose on collagen formation by mesangial cells
MH Baccora, P Cortes, C Hassett, DW Taube, J Yee |
Kidney International | 2007 |
|
Hyperglycemia and hyperinsulinemia have additive effects on activation and proliferation of pancreatic stellate cells: Possible explanation of islet-specific fibrosis in type 2 diabetes mellitus
OK Hong, SH Lee, M Rhee, SH Ko, JH Cho, YH Choi, KH Song, HY Son, KH Yoon |
Journal of Cellular Biochemistry | 2007 |
|
Kidney growth, hypertrophy and the unifying mechanism of diabetic complications
J Satriano |
Amino Acids | 2007 |
|
The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats
A Gojo, K Utsunomiya, K Taniguchi, T Yokota, S Ishizawa, Y Kanazawa, H Kurata, N Tajima |
European Journal of Pharmacology | 2007 |
|
Oral administration of GW788388, an inhibitor of TGF-β type I and II receptor kinases, decreases renal fibrosis
M Petersen, M Thorikay, M Deckers, M Dinther, ET Grygielko, F Gellibert, AC de Gouville, S Huet, P Dijke, NJ Laping |
Kidney International | 2007 |
|
Protective effects of keishibukuryogan on the kidney of spontaneously diabetic WBN/Kob rats
T Nakagawa, H Goto, H Hikiami, T Yokozawa, N Shibahara, Y Shimada |
Journal of Ethnopharmacology | 2007 |
|
Hormonal status affects the progression of STZ-induced diabetes and diabetic renal damage in the VCD mouse model of menopause
M Keck, MJ Romero-Aleshire, Q Cai, PB Hoyer, HL Brooks |
American journal of physiology. Renal physiology | 2007 |
|
Profiling of human mesangial cell subproteomes reveals a role for calmodulin in glucose uptake
SP Rao, R Wassell, MA Shaw, K Sharma |
American journal of physiology. Renal physiology | 2007 |
|
Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes
M Guha, ZG Xu, D Tung, L Lanting, R Natarajan |
The FASEB Journal | 2007 |
|
Hexosamines, insulin resistance, and the complications of diabetes: current status
MG Buse |
American journal of physiology. Endocrinology and metabolism | 2006 |
|
Mesangial Cell Hypertrophy by High Glucose Is Mediated by Downregulation of the Tumor Suppressor PTEN
L Mahimainathan, F Das, B Venkatesan, GG Choudhury |
Diabetes | 2006 |
|
Growth factors in diabetic complications
SE Thomson, SV McLennan, SM Twigg |
Expert Review of Clinical Immunology | 2006 |
|
The inhibitory effect of siRNAs on the high glucose-induced overexpression of TGF-beta1 in mesangial cells
HJ Noh, HC Kim, SS Lee, YN Kang, YM Chae, KK Park |
Journal of Korean Medical Science | 2006 |
|
Enhanced Effect of Combined Treatment with SMP-534 (Antifibrotic Agent) and Losartan in Diabetic Nephropathy
E Sugaru, T Nakagawa, M Ono-Kishino, J Nagamine, T Tokunaga, M Kitoh, WE Hume, R Nagata, M Taiji |
American Journal of Nephrology | 2006 |
|
Effect of salt intake on progression of chronic kidney disease
PW Sanders |
Current Opinion in Nephrology and Hypertension | 2006 |
|
Influence of C-peptide on early glomerular changes in diabetic mice
Y Maezawa, K Yokote, K Sonezaki, M Fujimoto, K Kobayashi, H Kawamura, T Tokuyama, M Takemoto, S Ueda, T Kuwaki, S Mori, J Wahren, Y Saito |
Diabetes/Metabolism Research and Reviews | 2006 |
|
Ras modulation of superoxide activates ERK-dependent fibronectin expression in diabetes-induced renal injuries
CL Lin, FS Wang, YR Kuo, YT Huang, HC Huang, YC Sun, YH Kuo |
Kidney International | 2006 |
|
Glucose enhances mesangial cell apoptosis
T Khera, J Martin, S Riley, R Steadman, AO Phillips |
Laboratory Investigation | 2006 |
|
The Pathogenesis of Myocardial Fibrosis in the Setting of Diabetic Cardiomyopathy
J Asbun, FJ Villarreal |
Journal of the American College of Cardiology | 2006 |
|
A longitudinal evaluation of urinary glycosaminoglycan excretion in normoalbuminuric type 1 diabetic patients
PD Muro, P Fresu, G Tonolo, M Maioli, GB Cherchi, A Murgia, C Ibba, GM Sanna, GM Cherchi |
Clinical Chemistry and Laboratory Medicine | 2006 |
|
The Effect of High Glucose and TGF-β on the Cellular Injury in Cultured Glomerular Epithelial Cells
GH Jeong, SC Chung, ED Jung, YJ Doh, HK Kim, SH Park, IH Park, JG Kim, SW Ha, BW Kim, IK Lee, CW Ko |
The Journal of Korean Diabetes Association | 2006 |
|
Urinary TGF-β1 reduction related to a decrease of systolic blood pressure in patients with type 2 diabetes and clinical diabetic nephropathy
MC Bertoluci, D Uebel, A Schmidt, FC Thomazelli, FR Oliveira, H Schmid |
Diabetes Research and Clinical Practice | 2006 |
|
Nuclear Translocation of SMAD3 May Enhance the TGF-β/SMADS Pathway in High Glucose Circumstances
Q Li, F Ye, Y Shi, L Zhang, W Wang, Z Tu, J Qiu, J Wang, S Li, H Bu, Y Li |
Transplantation Proceedings | 2006 |
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Salutary Effect of Pigment Epithelium-Derived Factor in Diabetic Nephropathy: Evidence for Antifibrogenic Activities
JJ Wang, SX Zhang, R Mott, RR Knapp, W Cao, K Lau, J Ma |
Diabetes | 2006 |
|
SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic db/db mice
E Sugaru, T Nakagawa, M Ono-Kishino, J Nagamine, T Tokunaga, M Kitoh, WE Hume, R Nagata, M Taiji |
American journal of physiology. Renal physiology | 2006 |
|
Streptococcal modulation of cellular invasion via TGF-β1 signaling
B Wang, S Li, PJ Southern, PP Cleary |
Proceedings of the National Academy of Sciences | 2006 |
|
The Diabetic Kidney
P Cortes, CE Mogensen |
2006 | |
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Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression
M Jinnin, H Ihn, K Tamaki |
Molecular pharmacology | 2005 |
|
Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-beta produced by tubular epithelial cells in response to high glucose
T Kobayashi, T Inoue, H Okada, T Kikuta, Y Kanno, T Nishida, M Takigawa, T Sugaya, H Suzuki |
Clinical and Experimental Nephrology | 2005 |
|
Cellular mechanisms and treatment of diabetes vascular complications converge on reactive oxygen species
CI Whiteside |
Current Hypertension Reports | 2005 |
|
Development of diabetic nephropathy in the Milan normotensive strain, but not in the Milan hypertensive strain: Possible permissive role of hemodynamics
G Pugliese, F Pricci, P Barsotti, C Iacobini, C Ricci, G Oddi, G Romeo, G Leto, G Marano, M Sorcini, M Sabbatini, G Fuiano, UD Mario, F Pugliese |
Kidney International | 2005 |
|
Interaction of haemodynamic and metabolic pathways in the genesis of diabetic nephropathy
CA Leon, L Raij |
Journal of Hypertension | 2005 |
|
Long-term treatment with Hachimi-jio-gan attenuates kidney damage in spontaneously diabetic WBN/Kob rats
T Nakagawa, T Yokozawa, N Yamabe, H Goto, N Shibahara, DY Rhyn, Y Shimada |
Journal of Pharmacy and Pharmacology | 2005 |
|
High glucose stimulates hepatic stellate cells to proliferate and to produce collagen through free radical production and activation of mitogen-activated protein kinase
R Sugimoto, M Enjoji, M Kohjima, S Tsuruta, M Fukushima, M Iwao, T Sonta, K Kotoh, T Inoguchi, M Nakamuta |
Liver International | 2005 |
|
Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: implication of gangliosides
E Masson, N Wiernsperger, M Lagarde, SE Bawab |
Biochemical Journal | 2005 |
|
Purinergic modulation of mesangial extracellular matrix production: Role in diabetic and other glomerular diseases
A Solini, C Iacobini, C Ricci, P Chiozzi, L Amadio, F Pricci, UD Mario, FD Virgilio, G Pugliese |
Kidney International | 2005 |
|
Plasminogen activator inhibitor-1 gene deficiency attenuates TGF-beta1-induced kidney disease
S Krag, CC Danielsen, P Carmeliet, J Nyengaard, L Wogensen |
Kidney International | 2005 |
|
Expression Patterns of Plasma Proteins in Spontaneously Diabetic Rats after Oral Administration of a Kampo Medicine, Hachimi-jio-gan, Using SELDI ProteinChip Platform
C Kiga, T Nakagawa, K Koizumi, H Sakurai, Y Shibagaki, K Ogawa, H Goto, I Saiki |
Biological & Pharmaceutical Bulletin | 2005 |
|
Effect of heparin on high glucose induced proliferation and expression of matrix metalloproteinases in normal human mesangial cells
Q Zhou, Y Yuichiro, T Masatoshi, N Tsuyoshi, S Atsushi, H Kouji, Y Zhang, X Lin, Y Zhang, A Terukatsu |
Journal of Central South University of Technology | 2005 |
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Expression of Gremlin, a Bone Morphogenetic Protein Antagonist, in Human Diabetic Nephropathy
V Dolan, M Murphy, D Sadlier, D Lappin, P Doran, C Godson, F Martin, Y O’Meara, H Schmid, A Henger, M Kretzler, A Droguett, S Mezzano, HR Brady |
American Journal of Kidney Diseases | 2005 |
|
Inhibitory effects of Cnidium officinale Makino and Tabanus fulvus Meigan on the high glucose-induced proliferation of glomerular mesangial cells
SI Jeong, DH Kwak, S Lee, YK Choo, WH Woo, KS Keum, BK Choi, KY Jung |
Phytomedicine | 2005 |
|
Advanced glycation end products and the kidney
JM Bohlender, S Franke, G Stein, G Wolf |
American journal of physiology. Renal physiology | 2005 |
|
Mesangial cell-reduced Ca 2+ signaling in high glucose is due to inactivation of phospholipase C-β 3 by protein kinase C
H Frecker, S Munk, H Wang, C Whiteside |
American journal of physiology. Renal physiology | 2005 |
|
Diabetes und Herz
T Meinertz, P Rösen, D Ziegler, A Schömig, D Tschöpe |
2005 | |
|
Urinary Transforming Growth Factor-β1 in Feline Chronic Renal Failure
S ARATA, A OHMI, F MIZUKOSHI, K BABA, K OHNO, A SETOGUCHI, H TSUJIMOTO |
Journal of Veterinary Medical Science | 2005 |
|
From Hyperglycemia to Diabetic Kidney Disease: The Role of Metabolic, Hemodynamic, Intracellular Factors and Growth Factors/Cytokines
BF Schrijvers, AS Vriese, A Flyvbjerg |
Endocrine reviews | 2004 |
|
Transforming growth factor-beta: A clinical target for the treatment of diabetic nephropathy
TA McGowan, Y Zhu, K Sharma |
Current Diabetes Reports | 2004 |
|
New insights into the pathophysiology of diabetic nephropathy: from haemodynamics to molecular pathology
G Wolf |
European Journal of Clinical Investigation | 2004 |
|
Activation of the Smad Pathway in Glomeruli from a Spontaneously Diabetic Rat Model, OLETF Rats
Y Furuse, N Hashimoto, M Maekawa, Y Toyama, A Nakao, I Iwamoto, K Sakurai, Y Suzuki, K Yagui, S Yuasa, K Toshimori, Y Saito |
Nephron Experimental Nephrology | 2004 |
|
Repeated Streptozotocin Injections Cause Early Onset of Glomerulosclerosis in Mice
S MIZUNO, J WEN, Y MIZUNO-HORIKAWA |
Experimental Animals | 2004 |
|
Effect of antisense TGF-beta1 oligodeoxynucleotides in streptozotocin- induced diabetic rat kidney
HS Jeong, KK Park, KK Park, SP Kim, IJ Choi, IK Lee, HC Kim |
Journal of Korean Medical Science | 2004 |
|
Regulation of glomerular endothelial cell proteoglycans by glucose
TS Ha, S Duraisamy, JL Faulkner, BS Kasinath |
Journal of Korean Medical Science | 2004 |
|
Renal proximal tubular epithelial cell transforming growth factor-beta1 generation and monocyte binding
XL Zhang, W Selbi, C la Motte, V Hascall, A Phillips |
The American Journal of Pathology | 2004 |
|
Cultured tubule cells from TGF-beta1 null mice exhibit impaired hypertrophy and fibronectin expression in high glucose
S Chen, BB Hoffman, JS Lee, Y Kasama, B Jim, JB Kopp, FN Ziyadeh |
Kidney International | 2004 |
|
AT1 and AT2 receptor in the kidney: role in health and disease
HM Siragy |
Seminars in Nephrology | 2004 |
|
Sp1-decoy oligodeoxynucleotide inhibits high glucose-induced mesangial cell proliferation
YM Chae, KK Park, J Magae, IS Lee, CH Kim, HC Kim, SH Hong, JG Lee, IJ Choi, HS Kim, KS Min, IK Lee, YC Chang |
Biochemical and Biophysical Research Communications | 2004 |
|
Effect of curcumin on extracellular matrix accumulation in the glomeruli in nephrotoxic sera nephritis rats
HY Bao |
Journal of Chinese Integrative Medicine | 2004 |
|
Expression of cavernous transforming growth factor-beta1 and its Type II Receptor in patients with erectile dysfunction
JK Ryu, JY Han, YC Chu, SU Song, KH Lee, SM Yoon, JK Suh, SJ Kim |
International Journal of Andrology | 2004 |
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Renal Proximal Tubular Epithelial Cell Transforming Growth Factor-β1 Generation and Monocyte Binding
XL Zhang, W Selbi, C la Motte, V Hascall, A Phillips |
The American Journal of Pathology | 2004 |
|
Phytolacca americana inhibits the high glucose-induced mesangial proliferation via suppressing extracellular matrix accumulation and TGF-β production
SI Jeong, KJ Kim, YK Choo, KS Keum, BK Choi, KY Jung |
Phytomedicine | 2004 |
|
Vascular factors altered in glucose-treated mesangial cells and diabetic glomeruli. Changes in vascular factors impair endothelial cell growth and matrix
AK Singh, KP Gudehithlu, AA Pegoraro, GK Singh, K Basheerudin, RB Robey, JA Arruda, G Dunea |
Laboratory Investigation | 2004 |
|
Ultrastructural alterations in capillaries of the diabetic hypertensive rat retina: protective effects of ACE inhibition
AA Dosso, E Rungger-Brändle, PM Leuenberger |
Diabetologia | 2004 |
|
Collagen I upregulates extracellular matrix gene expression and secretion of TGF-β1 by cultured human mesangial cells
R Ortega-Velazquez, M Gonzalez-Rubio, MP Ruiz-Torres, ML Diez-Marques, MC Iglesias, M Rodríguez-Puyol, D Rodríguez-Puyol |
American journal of physiology. Cell physiology | 2004 |
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Effect of high glucose on gene expression in mesangial cells: upregulation of the thiol pathway is an adaptational response
J Morrison, K Knoll, MJ Hessner, M Liang |
Physiological genomics | 2004 |
|
Hexosamines and TGF-β 1 use similar signaling pathways to mediate matrix protein synthesis in mesangial cells
LP Singh, K Green, M Alexander, S Bassly, ED Crook |
American journal of physiology. Renal physiology | 2004 |
|
Upstream Stimulatory Factor (USF) Proteins Induce Human TGF -β 1 Gene Activation via the Glucose-response Element–1013/–1002 in Mesangial Cells: UP-REGULATION OF USF ACTIVITY BY THE HEXOSAMINE BIOSYNTHETIC PATHWAY
C Weigert, K Brodbeck, M Sawadogo, HU Häring, ED Schleicher |
The Journal of biological chemistry | 2004 |
|
Urinary transforming growth factor-β1 in various types of nephropathy
PD Muro, R Faedda, P Fresu, A Masala, A Cigni, G Concas, MG Mela, A Satta, A Carcassi, GM Sanna, GM Cherchi |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2004 |
|
Emodin ameliorates glucose-induced matrix synthesis in human peritoneal mesothelial cells
TM Chan, JK Leung, RC Tsang, ZH Liu, LS Li, S Yung |
Kidney International | 2003 |
|
Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells
K Sharma, L Deelman, M Madesh, B Kurz, E Ciccone, S Siva, T Hu, Y Zhu, L Wang, R Henning, X Ma, G Hajnoczky |
American journal of physiology. Renal physiology | 2003 |
|
Extracellular Matrix Metabolism in Diabetic Nephropathy
RM Mason, NA Wahab |
Journal of the American Society of Nephrology : JASN | 2003 |
|
Reactive Oxygen Species-Regulated Signaling Pathways in Diabetic Nephropathy
HB Lee, MR Yu, Y Yang, Z Jiang, H Ha |
Journal of the American Society of Nephrology : JASN | 2003 |
|
Role of TGF-beta signaling in extracellular matrix production under high glucose conditions
JH Li, XR Huang, HJ Zhu, R Johnson, HY Lan |
Kidney International | 2003 |
|
Glutamine:fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-?1 and fibronectin expression in mesangial cells
C Weigert, U Friess, K Brodbeck, HU Hring, ED Schleicher |
Diabetologia | 2003 |
|
Hypertension Accelerates Diabetic Nephropathy in Wistar Fatty Rats, a Model of Type 2 Diabetes Mellitus, via Mitogen-Activated Protein Kinase Cascades and Transforming Growth Factor-.BETA.1
G IMAI, T SATOH, T KUMAI, M MURAO, H TSUCHIDA, Y SHIMA, G OGIMOTO, T FUJINO, S KOBAYASHI, K KIMURA |
Hypertension Research | 2003 |
|
Glucose-induced fibronectin and collagen type III expression in renal fibroblasts can occur independent of TGF-beta1
S Lam, NA Verhagen, F Strutz, JW van der Pijl, MR Daha, CV Kooten |
Kidney International | 2003 |
|
The renin-angiotensin system and the long-term complications of diabetes: pathophysiological and therapeutic considerations
RE Gilbert, H Krum, J Wilkinson-Berka, DJ Kelly |
Diabetic Medicine | 2003 |
|
Vitamin D3 up-regulated protein-1 regulates collagen expression in mesangial cells
T Kobayashi, S Uehara, T Ikeda, H Itadani, H Kotani |
Kidney International | 2003 |
|
Effect of enalapril and losartan on the events that precede diabetic nephropathy in rats
RA Volpini, CG da Silva, RS Costa, TM Coimbra |
Diabetes/Metabolism Research and Reviews | 2003 |
|
Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop
D Fraser, N Brunskill, T Ito, A Phillips |
The American Journal of Pathology | 2003 |
|
Treatment for Hyperglycemia Promotes Pancreatic Regeneration in Rats Without CCK-1 Receptor Gene Expression
M Yamamoto, DM Jia, KI Fukumitsu, M Otsuki |
Pancreas | 2003 |
|
Insulin resistance in African Americans
B Falkner |
Kidney International | 2003 |
|
Reversibility of established diabetic glomerulopathy by anti-TGF-β antibodies in db/db mice
S Chen, MC la Cruz, B Jim, SW Hong, M Isono, FN Ziyadeh |
Biochemical and Biophysical Research Communications | 2003 |
|
Long-Term Exposure of Proximal Tubular Epithelial Cells to Glucose Induces Transforming Growth Factor-β1 Synthesis via an Autocrine PDGF Loop
D Fraser, N Brunskill, T Ito, A Phillips |
The American Journal of Pathology | 2003 |
|
Effect of glucose on the expression of type I collagen and transforming growth factor-β1 in cultured human peritoneal fibroblasts
GM Saed, MP Diamond |
Fertility and Sterility | 2003 |
|
Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy
M Fujimoto, Y Maezawa, K Yokote, K Joh, K Kobayashi, H Kawamura, M Nishimura, AB Roberts, Y Saito, S Mori |
Biochemical and Biophysical Research Communications | 2003 |
|
c-Fos-driven transcriptional activation of transforming growth factor β-1: inhibition of high glucose-induced promoter activity by thiazolidinediones
C Weigert, K Brodbeck, A Bierhaus, HU Häring, ED Schleicher |
Biochemical and Biophysical Research Communications | 2003 |
|
The effect of ramipril on albumin excretion in diabetes and hypertension
LM Russo, GC Brammar, G Jerums, WD Comper, TM Osicka |
Journal of Hypertension | 2003 |
|
Diabetic nephropathy and transforming growth factor-β: transforming our view of glomerulosclerosis and fibrosis build-up
S Chen, B Jim, FN Ziyadeh |
Seminars in Nephrology | 2003 |
|
Differential behavior of mesangial cells derived from 12/15-lipoxygenase knockout mice relative to control mice1
YS Kim, MA Reddy, L Lanting, SG Adler, R Natarajan |
Kidney International | 2003 |
|
Expression of TGF-beta-induced matrix protein betaig-h3 is up-regulated in the diabetic rat kidney and human proximal tubular epithelial cells treated with high glucose
SH Lee, JS Bae, SH Park, BH Lee, RW Park, JY Choi, JY Park, SW Ha, YL Kim, TH Kwon, IS Kim |
Kidney International | 2003 |
|
The role of cell cycle proteins in Glomerular disease
SV Griffin, R Pichler, T Wada, M Vaughan, R Durvasula, SJ Shankland |
Seminars in Nephrology | 2003 |
|
Intervention strategies to prevent pathogenetic effects of glycated albumin
MP Cohen |
Archives of Biochemistry and Biophysics | 2003 |
|
Management of Diabetic Nephropathy
B Schrijvers, AD Vriese, A Flyvbjerg |
Management of Diabetic Nephropathy | 2003 |
|
Effects of high glucose on cytokine-induced nerve growth factor (NGF) expression in rat renal mesangial cells
K Heese, KF Beck, MH Behrens, K Plüss, W Fierlbeck, A Huwiler, H Mühl, H Geiger, U Otten, J Pfeilschifter |
Biochemical Pharmacology | 2003 |
|
Suppressions of chronic glomerular injuries and TGF- 1 production by HGF in attenuation of murine diabetic nephropathy
S Mizuno |
AJP Renal Physiology | 2003 |
|
Amino acids induce indicators of response to injury in glomerular mesangial cells
RL Meek, SK Cooney, SD Flynn, RF Chouinard, MH Poczatek, JE Murphy-Ullrich, KR Tuttle |
American journal of physiology. Renal physiology | 2003 |
|
Overexpression of the complementary DNA for human glutamine:fructose-6-phosphate amidotransferase in mesangial cells enhances glucose-induced fibronectin synthesis and transcription factor cyclic adenosine monophosphate-responsive element binding phosphorylation
Lalit P Singh, Michelle Alexander, Kenneith Greene, Errol D Crook |
Journal of Investigative Medicine | 2003 |
|
Smad3 and PKCδ mediate TGF-β 1 -induced collagen I expression in human mesangial cells
CE Runyan, HW Schnaper, AC Poncelet |
American journal of physiology. Renal physiology | 2003 |
|
TGF-?-induced protein ?ig-h3 is upregulated by high glucose in vascular smooth muscle cells
SW Ha, JS Bae, HJ Yeo, SH Lee, JY Choi, YK Sohn, JG Kim, IS Kim, BW Kim |
Journal of Cellular Biochemistry | 2003 |
|
Overview of Glucose Signaling in Mesangial Cells in Diabetic Nephropathy
M Haneda, D Koya, M Isono, R Kikkawa |
Journal of the American Society of Nephrology : JASN | 2003 |
|
The Lack of Cyclin Kinase Inhibitor p27 Kip1 Ameliorates Progression of Diabetic Nephropathy
M Awazu, S Omori, K Ishikura, M Hida, H Fujita |
Journal of the American Society of Nephrology : JASN | 2003 |
|
Add-On Anti–TGF-β Antibody to ACE Inhibitor Arrests Progressive Diabetic Nephropathy in the Rat
A Benigni, C Zoja, D Corna, C Zatelli, S Conti, M Campana, E Gagliardini, D Rottoli, C Zanchi, M Abbate, S Ledbetter, G Remuzzi |
Journal of the American Society of Nephrology : JASN | 2003 |
|
Amelioration of Diabetic Nephropathy in SPARC-Null Mice
S Taneda, JW Pippin, EH Sage, KL Hudkins, Y Takeuchi, WG Couser, CE Alpers |
Journal of the American Society of Nephrology : JASN | 2003 |
|
Overview: Combating Diabetic Nephropathy
FN Ziyadeh, K Sharma |
Journal of the American Society of Nephrology : JASN | 2003 |
|
p27 Kip1 : The “Rosebud” of Diabetic Nephropathy?
G Wolf, SJ Shankland |
Journal of the American Society of Nephrology : JASN | 2003 |
|
Inhibitory Smads and TGF-β Signaling in Glomerular Cells
M Schiffer, LE Schiffer, A Gupta, AS Shaw, IS Roberts, P Mundel, EP Böttinger |
Journal of the American Society of Nephrology : JASN | 2002 |
|
Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes
MC la Cruz, FN Ziyadeh, M Isono, M Kouahou, DC Han, R Kalluri, P Mundel, S Chen |
Kidney International | 2002 |
|
Independent Regulation of Transforming Growth Factor-β1 Transcription and Translation by Glucose and Platelet-Derived Growth Factor
D Fraser, L Wakefield, A Phillips |
The American Journal of Pathology | 2002 |
|
Independent regulation of transforming growth factor-beta1 transcription and translation by glucose and platelet-derived growth factor
D Fraser, L Wakefield, A Phillips |
The American Journal of Pathology | 2002 |
|
Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240
N Abdel-Wahab, SJ Wicks, RM Mason, A Chantry |
Biochemical Journal | 2002 |
|
Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-β-induced fibronectin in mesangial cells
M Isono, S Chen, SW Hong, MC la Cruz, FN Ziyadeh |
Biochemical and Biophysical Research Communications | 2002 |
|
Role of transforming growth factor beta in peritoneal fibrosis
RH Al-Jayyousi, JF Medcalf, KP Harris |
Nephrology | 2002 |
|
Glucose-induced oxidative stress in mesangial cells
MA Catherwood, LA Powell, P Anderson, D McMaster, PC Sharpe, ER Trimble |
Kidney International | 2002 |
|
Troglitazone suppresses the secretion of type I collagen by mesangial cells in vitro
RE Routh, JH Johnson, KJ McCarthy |
Kidney International | 2002 |
|
High glucose-enhanced activation of mesangial cell p38 MAPK by ET-1, ANG II, and platelet-derived growth factor
E Tsiani, P Lekas, IG Fantus, J Dlugosz, C Whiteside |
American journal of physiology. Endocrinology and metabolism | 2002 |
|
Connective Tissue Growth Factor and Regulation of the Mesangial Cell Cycle: Role in Cellular Hypertrophy
NA Wahab, BS Weston, T Roberts, RM Mason |
Journal of the American Society of Nephrology : JASN | 2002 |
|
Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542
NJ Laping, E Grygielko, A Mathur, S Butter, J Bomberger, C Tweed, W Martin, J Fornwald, R Lehr, J Harling, L Gaster, JF Callahan, BA Olson |
Molecular pharmacology | 2002 |
|
Fibronectin expression in proximal tubules from ischemic rat kidneys without reperfusion
Guillermo Petrini, Elena J Ochoa, Esteban Serra, Adriana M Torres, M Monica Elías |
Molecular and Cellular Biochemistry | 2002 |
|
Protein kinase C and the development of diabetic vascular complications
KJ Way, N Katai, GL King |
Diabetic Medicine | 2001 |
|
Hydrogen peroxide increases extracellular matrix mRNA through TGF-β in human mesangial cells
MC la Cruz, P Ruiz-Torres, J Alcamí, L Díez-Marqués, R Ortega-Velázquez, S Chen, M Rodríguez-Puyol, FN Ziyadeh, D Rodríguez-Puyol |
Kidney International | 2001 |
|
Pathogenesis of diabetic nephropathy: focus on transforming growth factor-β and connective tissue growth factor
OV Sakharova, MW Taal, BM Brenner |
Current Opinion in Nephrology and Hypertension | 2001 |
|
Glycated albumin stimulates TGF-beta1 production and protein kinase C activity in glomerular endothelial cells1
S Chen, MP Cohen, GT Lautenslager, CW Shearman, FN Ziyadeh |
Kidney International | 2001 |
|
Low-molecular-weight heparin prevents high glucose- and phorbol ester-induced TGF-beta1 gene activation
C Weigert, K Brodbeck, HU Haring, G Gambaro, ED Schleicher |
Kidney International | 2001 |
|
CONNECTIVE TISSUE GROWTH FACTOR AND ITS REGULATION: A NEW ELEMENT IN DIABETIC GLOMERULOSCLEROSIS
BL Riser, P Cortes |
Renal Failure | 2001 |
|
THE KEY ROLE OF THE TRANSFORMING GROWTH FACTOR-β SYSTEM IN THE PATHOGENESIS OF DIABETIC NEPHROPATHY
S Chen, SW Hong, MC Cruz, M Isono, A Casaretto, FN Ziyadeh |
Renal Failure | 2001 |
|
Protein kinase C inhibitors in the treatment and prevention of diabetic complications
A Gabriele, GL King |
Current Opinion in Endocrinology & Diabetes | 2001 |
|
Long-term exposure to high glucose up-regulates VCAM-induced endothelial cell adhesiveness to PBMC
C Esposito, G Fasoli, A Plati, N Bellotti, MM Conte, F Cornacchia, A Foschi, T Mazzullo, L Semeraro, AD Canton |
Kidney International | 2001 |
|
Increased Glomerular and Tubular Expression of Transforming Growth Factor-β1, Its Type II Receptor, and Activation of the Smad Signaling Pathway in the db/db Mouse
SW Hong, M Isono, S Chen, MC la Cruz, DC Han, FN Ziyadeh |
The American Journal of Pathology | 2001 |
|
TGF-beta: a crucial component of the pathogenesis of diabetic nephropathy
S Goldfarb, FN Ziyadeh |
Transactions of the American Clinical and Climatological Association | 2001 |
|
Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse
SW Hong, M Isono, S Chen, MC la Cruz, DC Han, FN Ziyadeh |
The American Journal of Pathology | 2001 |
|
High glucose-induced hypertrophy of mesangial cells requires p27(Kip1), an inhibitor of cyclin-dependent kinases
G Wolf, R Schroeder, G Zahner, RA Stahl, SJ Shankland |
The American Journal of Pathology | 2001 |
|
ERK Mediates Effects of Glycated Albumin in Mesangial Cells
MP Cohen, E Shea, CW Shearman |
Biochemical and Biophysical Research Communications | 2001 |
|
High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta1
SH Park, HJ Choi, JH Lee, CH Woo, JH Kim, HJ Han |
Kidney International | 2001 |
|
TRANSFORMING GROWTH FACTOR (β1) IN TESTES OF AGED AND DIABETIC RATS: CORRELATION WITH TESTICULAR FUNCTION
N Salama, M Tsuji, M Tamura, S Kagawa |
Systems Biology in Reproductive Medicine | 2001 |
|
Increased secretion of TGF-β1 by peripheral blood mononuclear cells from patients with Type 1 diabetes mellitus with diabetic nephropathy
E Korpinen, PH Groop, JA Fagerudd, AM Teppo, HK Åkerblom, O Vaarala |
Diabetic Medicine | 2001 |
|
High glucose levels enhance TGF-β1–thrombospondin-1 pathway in cultured human mesangial cells via mechanisms dependent on glucose-induced PKC activation
H Tada, K Kuboki, K Nomura, T Inokuchi |
Journal of Diabetes and its Complications | 2001 |
|
Advanced glycosylation end products stimulate collagen mRNA synthesis in mesangial cells mediated by protein kinase C and transforming growth factor–beta
YS Kim, BC Kim, CY Song, HK Hong, KC Moon, HS Lee |
Journal of Laboratory and Clinical Medicine | 2001 |
|
Small proteoglycans in human diabetic nephropathy: discrepancy between glomerular expression and protein accumulation of decorin, biglycan, lumican, and fibromodulin
L Schaefer, I Raslik, HJ Grone, E Schonherr, K Macakova, J Ugorcakova, S Budny, RM Schaefer, H Kresse |
The FASEB Journal | 2001 |
|
Overexpression of glutamine:fructose-6-phosphate-amidotransferase induces transforming growth factor-β1 synthesis in NIH-3T3 fibroblasts
C Weigert, K Brodbeck, R Lehmann, HU Häring, ED Schleicher |
FEBS Letters | 2001 |
|
Transforming growth factor-β as a target for treatment in diabetic nephropathy
DP Basile |
American Journal of Kidney Diseases | 2001 |
|
Tetrahydrobiopterin reverses the inhibition of nitric oxide by high glucose in cultured murine mesangial cells
SS Prabhakar |
American journal of physiology. Renal physiology | 2001 |
|
Antisense GLUT-1 protects mesangial cells from glucose induction of GLUT-1 and fibronectin expression
CW Heilig, JI Kreisberg, S Freytag, T Murakami, Y Ebina, L Guo, K Heilig, R Loberg, X Qu, Y Jin, D Henry, FC Brosius |
American journal of physiology. Renal physiology | 2001 |
|
Renal fibrosis in diabetic and aortic-constricted hypertensive rats
B Gallego, MA Arévalo, O Flores, JM López-Novoa, F Pérez-Barriocanal |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2001 |
|
Monocyte/mesangial cell interactions in high‐glucose co‐cultures
P Menè, C Caenazzo, F Pugliese, GA Cinotti, A D'Angelo, S Garbisa, G Gambaro |
Nephrology Dialysis Transplantation | 2001 |
|
Role of the hexosamine biosynthetic pathway in diabetic nephropathy
ED Schleicher, C Weigert |
Kidney International | 2000 |
|
Amadori-glycated albumin in diabetic nephropathy: Pathophysiologic connections
S Chen, MP Cohen, FN Ziyadeh |
Kidney International | 2000 |
|
Effects of diabetes and hypertension on glomerular transforming growth factor-beta receptor expression
MJ Kang, A Ingram, H Ly, K Thai, JW Scholey |
Kidney International | 2000 |
|
Role of angiotensin II in diabetic nephropathy
DJ Leehey, AK Singh, N Alavi, R Singh |
Kidney International | 2000 |
|
Cell cycle regulation in diabetic nephropathy
G Wolf |
Kidney International | 2000 |
|
Glucose Stimulation of Transforming Growth Factor-β Bioactivity in Mesangial Cells Is Mediated by Thrombospondin-1
MH Poczatek, C Hugo, V Darley-Usmar, JE Murphy-Ullrich |
The American Journal of Pathology | 2000 |
|
Smad proteins and transforming growth factor-beta signaling
M Schiffer, GV Gersdorff, M Bitzer, K Susztak, EP Bottinger |
Kidney International | 2000 |
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Effects of glucose on matrix metalloproteinase and plasmin activities in mesangial cells: Possible role in diabetic nephropathy
SV Mclennan, E Fisher, SY Martell, AK Death, PF Williams, JG Lyons, DK Yue |
Kidney International | 2000 |
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Transforming growth factor beta contributes to progressive diabetic nephropathy
WB Reeves, TE Andreoli |
Proceedings of the National Academy of Sciences | 2000 |
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Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice
FN Ziyadeh, BB Hoffman, DC Han, MC la Cruz, SW Hong, M Isono, S Chen, TA McGowan, K Sharma |
Proceedings of the National Academy of Sciences | 2000 |
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Glucose stimulation of transforming growth factor-beta bioactivity in mesangial cells is mediated by thrombospondin-1
MH Poczatek, C Hugo, V Darley-Usmar, JE Murphy-Ullrich |
The American Journal of Pathology | 2000 |
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Activation of transforming growth factor-β1 in diabetic kidney disease
B Hellmich, M Schellner, H Schatz, A Pfeiffer |
Metabolism | 2000 |
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TGF-β in diabetic kidney disease: role of novel signaling pathways
K Sharma, TA McGowan |
Cytokine & Growth Factor Reviews | 2000 |
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Transforming growth factor-beta mRNA and protein in hypertrophic scar tissues and fibroblasts: antagonism by IFN-alpha and IFN-gamma in vitro and in vivo
EE Tredget, R Wang, Q Shen, PG Scott, A Ghahary |
Journal of Interferon & Cytokine Research | 2000 |
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F(2)-isoprostanes mediate high glucose-induced TGF-beta synthesis and glomerular proteinuria in experimental type I diabetes
A Montero, KA Munger, RZ Khan, JM Valdivielso, JD Morrow, A Guasch, FN Ziyadeh, KF Badr |
Kidney International | 2000 |
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Transcriptional Regulation of Transforming Growth Factor β1 by Glucose: Investigation into the Role of the Hexosamine Biosynthesis Pathway
MC Daniels, DA McClain, ED Crook |
The American Journal of the Medical Sciences | 2000 |
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Hexosamine regulation of glucose-mediated laminin synthesis in mesangial cells involves protein kinases A and C
LP Singh, ED Crook |
American journal of physiology. Renal physiology | 2000 |
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Stimulation of TGF-β type II receptor by high glucose in mouse mesangial cells and in diabetic kidney
M Isono, A Mogyorósi, DC Han, BB Hoffman, FN Ziyadeh |
American journal of physiology. Renal physiology | 2000 |
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Therapy with antisense TGF-β1 oligodeoxynucleotides reduces kidney weight and matrix mRNAs in diabetic mice
DC Han, BB Hoffman, SW Hong, J Guo, FN Ziyadeh |
American journal of physiology. Renal physiology | 2000 |
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Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
D Koya, M Haneda, H Nakagawa, K Isshiki, H Sato, S Maeda, T Sugimoto, H Yasuda, A Kashiwagi, DK Ways, GL King, R Kikkawa |
The FASEB Journal | 2000 |
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Transcriptional Regulation of Transforming Growth Factor ??1 by Glucose: Investigation into the Role of the Hexosamine Biosynthesis Pathway:
MC Daniels, DA McClain, ED Crook |
The American Journal of the Medical Sciences | 2000 |
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INTRAGRAFT EXPRESSION OF TRANSFORMING GROWTH FACTOR-BETA 1 BY A NOVEL QUANTITATIVE REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION ELISA IN LONG LASTING KIDNEY RECIPIENTS1:
V Mas, A Diller, S Albano, C Giraudo, T Alvarellos, J Sena, P Massari, G de Boccardo |
Transplantation | 2000 |
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The Kidney and Hypertension in Diabetes Mellitus
CE Mogensen |
2000 | |
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Extracellular Signal-Regulated Kinase Mediates Stimulation of TGF-β1 and Matrix by High Glucose in Mesangial Cells
M Isono, MC Cruz, S Chen, SW Hong, FN Ziyadeh |
Journal of the American Society of Nephrology : JASN | 2000 |
|
AP-1 Proteins Mediate Hyperglycemia-Induced Activation of the Human TGF-β1 Promoter in Mesangial Cells
C Weigert, U Sauer, K Brodbeck, A Pfeiffer, HU Häring, ED Schleicher |
Journal of the American Society of Nephrology : JASN | 2000 |
|
Catecholamines and angiotensinogen gene expression in kidney proximal tubular cells
J S Chan, T T Wang, S L Zhang, X Chen, S Carrière |
Molecular and Cellular Biochemistry | 2000 |
|
Regulation of angiotensin II receptors in the medullary thick ascending limb
D H Wang, J Li |
Molecular and Cellular Biochemistry | 2000 |
|
TGF-beta receptor expression and binding in rat mesangial cells: Modulation by glucose and cyclic mechanical strain
BL Riser, S Ladson-Wofford, A Sharba, P Cortes, K Drake, CJ Guerin, J Yee, ME Choi, PR Segarini, RG Narins |
Kidney International | 1999 |
|
Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats
S Kato, VA Luyckx, M Ots, KW Lee, F Ziai, JL Troy, BM Brenner, HS Mackenzie |
Kidney International | 1999 |
|
High glucose alters the response of mesangial cell protein kinase C isoforms to endothelin-1
EA Glogowski, E Tsiani, X Zhou, IG Fantus, C Whiteside |
Kidney International | 1999 |
|
TGF-beta1 stimulates glucose uptake by enhancing GLUT1 expression in mesangial cells
K Inoki, M Haneda, S Maeda, D Koya, R Kikkawa |
Kidney International | 1999 |
|
Effect of glucose on stress-activated protein kinase activity in mesangial cells and diabetic glomeruli
MJ Kang, X Wu, H Ly, K Thai, JW Scholey |
Kidney International | 1999 |
|
Molecular mechanisms of diabetic renal hypertrophy
G Wolf, FN Ziyadeh |
Kidney International | 1999 |
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Renal proximal tubular cell fibronectin accumulation in response to glucose is polyol pathway dependent
K Morrisey, R Steadman, JD Williams, AO Phillips |
Kidney International | 1999 |
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Mesangial cell signaling cascades in response to mechanical strain and glucose
AJ Ingram, H Ly, K Thai, MJ Kang, JW Scholey |
Kidney International | 1999 |
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The transforming growth factor beta system in kidney disease and repair: recent progress and future directions
DP Basile |
Current Opinion in Nephrology and Hypertension | 1999 |
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Implications of Minocycline, Platelet-Derived Growth Factor, and Transforming Growth Factor-Beta on Inflammatory Repair Potential in the Periodontium
M Soory, H Virdi |
Journal of Periodontology | 1999 |
|
TACROLIMUS INDUCES INCREASED EXPRESSION OF TRANSFORMING GROWTH FACTOR-??1 IN MAMMALIAN LYMPHOID AS WELL AS NONLYMPHOID CELLS
A Khanna, V Cairns, JD Hosenpud |
Transplantation | 1999 |
|
Captopril-induced reduction of serum levels of transforming growth Factor-β1 correlates with long-term renoprotection in insulin-dependent diabetic patients☆☆☆
K Sharma, BO Eltayeb, TA McGowan, SR Dunn, B Alzahabi, R Rohde, FN Ziyadeh, EJ Lewis |
American Journal of Kidney Diseases | 1999 |
|
TGF-β and fibrosis
MH Branton, JB Kopp |
Microbes and Infection | 1999 |
|
TGF-β: from latent to active
N Khalil |
Microbes and Infection | 1999 |
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The effects of extracellular citric acid acidosis on the viability, cellular adhesion capacity and protein synthesis of cultured human gingival fibroblasts
WC Lan, WH Lan, CP Chan, CC Hsieh, MC Chang, JH Jeng |
Australian Dental Journal | 1999 |
|
High glucose modifies heparansulphate synthesis by mouse glomerular epithelial cells
S Morano, L Guidobaldi, R Cipriani, A Gabriele, F Pantellini, F Medici, M D'Erme, UD Mario |
Diabetes/Metabolism Research and Reviews | 1999 |
|
Pathophysiological Role of Growth Factors in Diabetic Kidney Disease: Focus on Innovative Therapy
A Flyvbjerg, C Hill, A Logan |
Trends in Endocrinology & Metabolism | 1999 |
|
Altered Plasma Levels of Nerve Growth Factor and Transforming Growth Factor-β2 in Type-1 Diabetes Mellitus
ST Azar, SC Major, B Safieh-Garabedian |
Brain, Behavior, and Immunity | 1999 |
|
Effects of Butyrate and Propionate on the Adhesion, Growth, Cell Cycle Kinetics, and Protein Synthesis of Cultured Human Gingival Fibroblasts
JH Jeng, CP Chan, YS Ho, WH Lan, CC Hsieh, MC Chang |
Journal of Periodontology | 1999 |
|
Potentiating effects of hyper-osmolality and epidermal growth factor on the release of arachidonic acid in human glomerular mesangial cells
SC Sansom, P Mehta, DA Hall |
Diabetes Research and Clinical Practice | 1999 |
|
Glycated albumin stimulation of PKC-β activity is linked to increased collagen IV in mesangial cells
MP Cohen, FN Ziyadeh, GT Lautenslager, JA Cohen, CW Shearman |
American journal of physiology. Renal physiology | 1999 |
|
LDL stimulates collagen mRNA synthesis in mesangial cells through induction of PKC and TGF-β expression
HS Lee, BC Kim, HK Hong, YS Kim |
American journal of physiology. Renal physiology | 1999 |
|
GLUT1 and TGF-β: the link between hyperglycaemia and diabetic nephropathy
A Mogyorósi, FN Ziyadeh |
Nephrology Dialysis Transplantation | 1999 |
|
SPARC Regulates the Expression of Collagen Type I and Transforming Growth Factor-β1 in Mesangial Cells
A Francki, AD Bradshaw, JA Bassuk, CC Howe, WG Couser, EH Sage |
The Journal of biological chemistry | 1999 |
|
Molecular and Cellular Pediatric Endocrinology
S Handwerger |
1999 | |
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Favorable Treatment Outcome with Neutralizing anti Transforming Growth Factor I:} Antibodies in Experimental Diabetic Kidney Disease
DC Han, FN Ziyadeh |
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis | 1999 |
|
Transforming Growth Factor-β Is a Potent Inhibitor of Extracellular Matrix Degradation by Cultured Human Mesangial Cells
WH Baricos, SL Cortez, M Deboisblanc, S XIN |
Journal of the American Society of Nephrology : JASN | 1999 |
|
Effects of Advanced Glycation End Products on Cytosolic Ca 2+ Signaling of Cultured Human Mesangial Cells
P Menè, C Pascale, A Teti, SI Bernardini, GA Cinotti, F Pugliese |
Journal of the American Society of Nephrology : JASN | 1999 |
|
High Glucose Solution and Spent Dialysate Stimulate the Synthesis of Transforming Growth Factor-β 1 of Human Peritoneal Mesothelial Cells: Effect of Cytokine Costimulation
DH Kang, YS Hong, HJ Lim, JH Choi, DS Han, KI Yoon |
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis | 1999 |
|
Extracellular matrix deposition and cell proliferation in a model of chronic glomerulonephritis in the rat
S Harendza, A Schneider, U Helmchen, RA Stahl |
Nephrology Dialysis Transplantation | 1999 |
|
High Glucose Stimulates Proliferation and Collagen Type I Synthesis in Renal Cortical Fibroblasts: Mediation by Autocrine Activation of TGF-β
DC Han, M Isono, BB Hoffman, FN Ziyadeh |
Journal of the American Society of Nephrology : JASN | 1999 |
|
Autocrine and paracrine mechanisms in the early stages of diabetic nephropathy
G Pugliese, F Pricci, G Romeo, G Leto, L Amadio, C Iacobini, UD Mario |
Journal of Endocrinological Investigation | 1999 |
|
High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells
V Kolm-Litty, U Sauer, A Nerlich, R Lehmann, ED Schleicher |
Journal of Clinical Investigation | 1998 |
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Effects of oral antihyperglycemic agents on extracellular matrix synthesis by mesangial cells
P Cortes, BL Riser, K Asano, A Rodríguez-Barbero, RG Narins, J Yee |
Kidney International | 1998 |
|
Effects of hypertonic stress on transforming growth factor-beta activity in normal rat kidney cells
T Sugiura, A Yamauchi, H Kitamura, Y Matusoka, M Horio, E Imai, M Hori |
Kidney International | 1998 |
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Serotonin enhances the production of type IV collagen by human mesangial cells
M Kasho, M Sakai, T Sasahara, Y Anami, T Matsumura, T Takemura, H Matsuda, S Kobori, M Shichiri |
Kidney International | 1998 |
|
Ddiabetic nephropathy as a of revrsibility of established renal lesions
P Fioretto, Y Kim, M Mauer |
Current Opinion in Nephrology and Hypertension | 1998 |
|
Sequential effects of high glucose on mesangial cell transforming growth factor-β1 and fibronectin synthesis
JH Oh, H Ha, MR Yu, HB Lee |
Kidney International | 1998 |
|
Effect of glucose on the expression of the angiotensinogen gene in opossum kidney cells
TT Wang, XH Wu, SL Zhang, JS Chan |
Kidney International | 1998 |
|
Hepatocyte growth factor as a potential index of complication in diabetes mellitus
S Nakamura, R Morishita, A Moriguchi, Y Yo, Y Nakamura, S Hayashi, K Matsumoto, K Matsumoto, T Nakamura, J Higaki, T Ogihara |
Journal of Hypertension | 1998 |
|
Glomerular expression of p27Kip1 in diabetic db/db mouse: Role of hyperglycemia
G Wolf, R Schroeder, F Thaiss, FN Ziyadeh, U Helmchen, RA Stahl |
Kidney International | 1998 |
|
Serine protease activity is essential for thrombin-induced protein synthesis in cultured human dental pulp cells: modulation roles of prostaglandin E2
MC Chang, WH Lan, CP Chan, CP Lin, CC Hsieh, JH Jeng |
Journal of Oral Pathology & Medicine | 1998 |
|
Angiotensin converting enzyme inhibition reduces the expression of transforming growth factor-β1 and type IV collagen in diabetic vasculopathy
JR Rumble, RE Gilbert, A Cox, L Wu, ME Cooper |
Journal of Hypertension | 1998 |
|
Glomerular expression of p27Kip1 in diabetic db/db mouse: Role of hyperglycemia
G Wolf, R Schroeder, F Thaiss, FN Ziyadeh, U Helmchen, RA Stahl |
Kidney International | 1998 |
|
Transcriptional activation of transforming growth factor-beta1 in mesangial cell culture by high glucose concentration
BB Hoffman, K Sharma, Y Zhu, FN Ziyadeh |
Kidney International | 1998 |
|
Intracellular Processing of Transforming Growth Factor–β in Mesangial Cells
M Ceol, D Vianello, B Baggio, A Meani, E Schleicher, F Anglani, G Gambaro |
Renal Failure | 1998 |
|
Expression of Cysteine Proteinases and Their Inhibitor, Cystatin β, in Cultured Rat Mesangial Cells
Y Makita, K Ishidoh, E Kominami, K Funabiki, H Koide, Y Tomino |
Journal of Diabetes and its Complications | 1998 |
|
Areca Nut Extract Inhibits the Growth, Attachment, and Matrix Protein Synthesis of Cultured Human Gingival Fibroblasts
MC Chang, MY Kuo, LJ Hahn, CC Hsieh, SK Lin, JH Jeng |
Journal of Periodontology | 1998 |
|
Autocrine Transforming Growth Factor β Stimulation of Extracellular Matrix Production by Fibroblasts From Fibrotic Human Gingiva
DA Tipton, MK Dabbous |
Journal of Periodontology | 1998 |
|
Advances in Organ Biology
AJ Liedtke |
Advances in Organ Biology | 1998 |
|
A central role for protein kinase C overactivity in diabetic glomerulosclerosis: implications for prevention with antioxidants, fish oil, and ACE inhibitors
MF McCarty |
Medical Hypotheses | 1998 |
|
TGF-β: A Link Between Immunosuppression, Nephrotoxicity, and CsA
AK Khanna, VR Cairns, CG Becker, JD Hosenpud |
Transplantation Proceedings | 1998 |
|
Glycated albumin stimulates fibronectin gene expression in glomerular mesangial cells: Involvement of the transforming growth factor-β system
FN Ziyadeh, DC Han, JA Cohen, J Guo, MP Cohen |
Kidney International | 1998 |
|
Growth Factors and the Kidney in Diabetes Mellitus
G Gambaro, B Baggio |
Critical Reviews in Clinical Laboratory Sciences | 1998 |
|
TGF-β Plays a Key Role in Morphogenesis of the Pancreatic Islets of Langerhans by Controlling the Activity of the Matrix Metalloproteinase MMP-2
F Miralles, T Battelino, P Czernichow, R Scharfmann |
The Journal of Cell Biology | 1998 |
|
Serum-stimulated α 1 type IV collagen gene transcription is mediated by TGF-β and inhibited by estradiol
J Lei, S Silbiger, FN Ziyadeh, J Neugarten |
American journal of physiology. Renal physiology | 1998 |
|
Increased decorin mRNA in diabetic mouse kidney and in mesangial and tubular cells cultured in high glucose
A Mogyorosi, FN Ziyadeh |
American journal of physiology. Renal physiology | 1998 |
|
Urinary measurement of transforming growth factor-β and type IV collagen as new markers of renal injury: application in diabetic nephropathy
D Ellis, KY Forrest, J Erbey, TJ Orchard |
Clinical chemistry | 1998 |
|
Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats
D Koya, MR Jirousek, YW Lin, H Ishii, K Kuboki, GL King |
Journal of Clinical Investigation | 1997 |
|
Role of glomerular mechanical strain in the pathogenesis of diabetic nephropathy
P Cortes, X Zhao, BL Riser, RG Narins |
Kidney International | 1997 |
|
Tyrosine kinase dependent expression of TGF-β induced by stretch in mesangial cells
M Hirakata, S Kaname, UG Chung, N Joki, Y Hori, M Noda, Y Takuwa, T Okazaki, T Fujita, T Katoh, K Kurokawa |
Kidney International | 1997 |
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The role of angiotensin II in diabetic nephropathy: Emphasis on nonhemodynamic mechanisms
G Wolf, FN Ziyadeh |
American Journal of Kidney Diseases | 1997 |
|
Transforming growth factor βs and wound healing
S O'Kane, MW Ferguson |
The International Journal of Biochemistry & Cell Biology | 1997 |
|
Pathogenesis of diabetic nephropathy
R Kikkawa, M Haneda |
Clinical and Experimental Nephrology | 1997 |
|
Mesangial cell actin disassembly in high glucose mediated by protein kinase C and the polyol pathway
X Zhou, C Li, J Dlugosz, J Kapor-Drezgic, S Munk, C Whiteside |
Kidney International | 1997 |
|
Growth factor antagonists for the treatment of diabetic vascular complications
RG Tilton, RA Dixon, TA Brock |
Expert Opinion on Investigational Drugs | 1997 |
|
Hyperosmolality suppresses but TGFβ1 increases MMP9 in human peritoneal mesothelial cells
JP Rougier, P Moullier, R Piedagnel, PM Ronco, S Guia |
Kidney International | 1997 |
|
Antioxidant inhibition of protein kinase C—signaled increases in transforming growth factor-beta in mesangial cells
RK Studer, PA Craven, FR Derubertis |
Metabolism | 1997 |
|
Transforming growth factor-β, other growth factors, and the extracellular matrix
MA Haralson |
Journal of Laboratory and Clinical Medicine | 1997 |
|
Effect of glucose, pyruvate, and insulin on type 1 angiotensin II receptor expression in SV40-immortalized rabbit proximal tubule epithelial cells
BN Becker, S Kondo, HF Cheng, RC Harris |
Kidney International | 1997 |
|
Exposure of human renal proximal tubular cells to glucose leads to accumulation of type IV collagen and fibronectin by decreased degradation
AO Phillips, R Steadman, K Morrisey, J Martin, L Eynstone, JD Williams |
Kidney International | 1997 |
|
D-glucose-induced dysmorphogenesis of embryonic kidney
YS Kanwar, ZZ Liu, A Kumar, MI Usman, J Wada, EI Wallner |
Journal of Clinical Investigation | 1996 |
|
Phosphorylation of cAMP responsive element binding protein after treatment of mesangial cells with high glucose plus TGFβ or PMA
JI Kreisberg, RA Radnik, SH Kreisberg |
Kidney International | 1996 |
|
Growth phenotype of cultured skin fibroblasts from IDDM patients with and without nephropathy and overactivity of the Na+/H+ antiporter
A Lurbe, P Fioretto, M Mauer, MS LaPointe, D Batlle |
Kidney International | 1996 |
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Regulation of basement membrane heparan sulfate proteoglycan, perlecan, gene expression in glomerular epithelial cells by high glucose medium
BS Kasinath, P Grellier, GG Choudhury, SL Abboud |
Journal of Cellular Physiology | 1996 |
|
Transforming Growth Factor β in Diabetic Nephropathy
WA Border, T Yamamoto, NA Noble |
Diabetes/Metabolism Reviews | 1996 |
|
Quantification of glomerular TGF-β1 mRNA in patients with diabetes mellitus
M Iwano, A Kubo, T Nishino, H Sato, H Nishioka, Y Akai, H Kurioka, Y Fujii, M Kanauchi, H Shiiki, K Dohi |
Kidney International | 1996 |
|
Intragraft TGF-β1 mRNA: A correlate of interstitial fibrosis and chronic allograft nephropathy
VK Sharma, RM Bologa, GP Xu, B Li, J Mouradian, J Wang, D Serur, V Rao, M Suthanthiran |
Kidney International | 1996 |
|
Cell-matrix interactions in the glomerular mesangium
HD Rupprecht, HO Schöcklmann, RB Sterzel |
Kidney International | 1996 |
|
High glucose concentration induces the overexpression of transforming growth factor-beta through the activation of a platelet-derived growth factor loop in human mesangial cells
SD Paolo, L Gesualdo, E Ranieri, G Grandaliano, FP Schena |
The American Journal of Pathology | 1996 |
|
Cyclic stretching force selectively up-regulates transforming growth factor-beta isoforms in cultured rat mesangial cells
BL Riser, P Cortes, C Heilig, J Grondin, S Ladson-Wofford, D Patterson, RG Narins |
The American Journal of Pathology | 1996 |
|
Hyperglycemia augments macrophage growth responses to colony-stimulating factor-1
A Saini, YJ Liu, DJ Cohen, BS Ooi |
Metabolism | 1996 |
|
Posttranscriptional effects of glucose on proteoglycan expression in mesangial cells
DM Templeton, MY Fan |
Metabolism | 1996 |
|
Induction of TGF-β1 synthesis in D-glucose primed human proximal tubular cells by IL-1β and TNFα
AO Phillips, N Topley, R Steadman, K Morrisey, JD Williams |
Kidney International | 1996 |
|
Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype
CW Heilig, LA Concepcion, BL Riser, SO Freytag, M Zhu, P Cortes |
Journal of Clinical Investigation | 1995 |
|
Expression of growth-related protooncogenes during diabetic renal hypertrophy
SJ Shankland, JW Scholey, H Ly, K Thai |
Kidney International | 1995 |
|
PDGF and TGF-β mediate collagen production by mesangial cells exposed to advanced glycosylation end products
DC Throckmorton, AP Brogden, B Min, H Rasmussen, M Kashgarian |
Kidney International | 1995 |
|
Protein kinase C signals thromboxane induced increases in fibronectin synthesis and TGF-β bioactivity in mesangial cells
RK Studer, H Negrete, PA Craven, FR DeRubertis |
Kidney International | 1995 |
|
Early glomerular changes in rats with dietary-induced hypercholesterolemia
C Guijarro, BL Kasiske, Y Kim, MP O'Donnell, HS Lee, WF Keane |
American Journal of Kidney Diseases | 1995 |
|
Elevated D-glucose concentrations modulate TGF-beta 1 synthesis by human cultured renal proximal tubular cells. The permissive role of platelet-derived growth factor
AO Phillips, R Steadman, N Topley, JD Williams |
The American Journal of Pathology | 1995 |
|
Pathogenesis of glomerulosclerosis in light chain deposition disease. Role for transforming growth factor-beta
L Zhu, GA Herrera, JE Murphy-Ullrich, ZQ Huang, PW Sanders |
The American Journal of Pathology | 1995 |
|
Protein kinase C in diabetic nephropathy
PA Craven, RK Studer, H Negrete, FR DeRubertis |
Journal of Diabetes and its Complications | 1995 |
|
Role of protein kinase C and cyclic AMP/protein kinase A in high glucose-stimulated transcriptional activation of collagen α1 (IV) in glomerular mesangial cells
FN Ziyadeh, P Fumo, CH Rodenberger, GS Kuncio, EG Neilson |
Journal of Diabetes and its Complications | 1995 |
|
High glucose and TGFβ1 stimulate fibronectin gene expression through a cAMP response element
JI Kreisberg, JA Garoni, R Radnik, SH Ayo |
Kidney International | 1994 |
|
Role of thrombospondin in mesangial cell growth: Possible existence of an autocrine feedback growth circuit
GN Marinides, SJ Suchard, BK Mookerjee |
Kidney International | 1994 |
|
Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations
SL Zhang, JG Filep, TC Hohman, SS Tang, JR Ingelfinger, JS Chan |
The American journal of physiology | 1993 |
|
Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations
SL Zhang, JG Filep, TC Hohman, SS Tang, JR Ingelfinger, JS Chan |
The American journal of physiology | 1993 |
|
Author's reply
TT Lao |
BJOG: An International Journal of Obstetrics and Gynaecology | 1990 |
|
Plasma and Urinary Type IV Collagen Levels for Early Detection of Nephropathy in Type 2 Diabetes Mellitus Patients
K Balu Mahendran, M Vijaya Bhaskar, K Santha, R Inmozhi, KK Perumal |
International journal of health sciences | |
|
Phosphatidylinositol 3′-Kinase-dependent Activation of Renal Mesangial Cell Ki-Ras and ERK by Advanced Glycation End Products
D Xu, JM Kyriakis |
The Journal of biological chemistry | 2003 |
|
Protein kinase C activation and its pharmacological inhibition in vascular disease
M Meier, GL King |
Vascular medicine (London, England) | 2000 |
|
Regulatory role of eicosanoids in extracellular matrix overproduction induced by long-term exposure to high glucose in cultured rat mesangial cells
F Pricci, G Pugliese, P Menè, G Romeo, G Romano, G Galli, A Casini, CM Rotella, UD Mario, F Pugliese |
Diabetologia | 1996 |
|
Increased activity of the insulin-like growth factor system in mesangial cells cultured in high glucose conditions. Relation to glucose-enhanced extracellular matrix production
G Pugliese, F Pricci, N Locuratolo, G Romeo, G Romano, S Gianninr, B Cresci, G Galli, CM Rotella, UD Mario |
Diabetologia | 1996 |
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