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Abstract
We and others have previously demonstrated that human alveolar macrophages produce more PGE2 in response to lipopolysaccharide (LPS) than do blood monocytes. We hypothesized that this observation was due to a greater increase in prostaglandin H synthase-2 (PGHS-2) enzyme mass in the macrophage compared to the monocyte. To evaluate this hypothesis, alveolar macrophages and blood monocytes were obtained from healthy nonsmoking volunteers. The cells were cultured in the presence of 0 to 10 micrograms/ml LPS. LPS induced the synthesis of large amounts of a new 75-kD protein in human alveolar macrophages, and a lesser amount in monocytes. Synthesis of this protein required more than 6 h and peaked in 24 to 48 h; the protein reacted with an anti-PGHS-2 antibody prepared against mouse PGHS-2. Associated with synthesis of the protein was a marked increase in LPS-stimulated and arachidonic acid-stimulated synthesis of PGE2 by alveolar macrophages compared to monocytes. Cells not exposed to LPS contained only PGHS-1 and synthesized very little PGE2 during culture or in response to exogenous arachidonic acid. An LPS-induced mRNA, which hybridized to a human cDNA probe for PGHS-2 mRNA, was produced in parallel with production of this new protein and was produced in much greater amounts by alveolar macrophages compared to blood monocytes. This mRNA was not detectable in cells not exposed to LPS. In contrast, both types of cells contain mRNA, which hybridizes to a cDNA probe for PGHS-1. This mRNA did not increase in response to LPS. LPS also had no effect on PGHS-1 protein. These data demonstrate that PGE2 synthesis in human alveolar macrophages and blood monocytes correlates to the mass of PGHS-2 in the cell. We conclude that the greater ability of the macrophage to synthesize PGE2 in response to LPS is due to greater synthesis of PGHS-2 by the macrophage.
Authors
S L Hempel, M M Monick, G W Hunninghake
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Cellular Signalling | 2003 |
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Tyrosine Phosphorylation of I-κB Kinase α/β by Protein Kinase C-Dependent c-Src Activation Is Involved in TNF-α-Induced Cyclooxygenase-2 Expression
WC Huang, JJ Chen, H Inoue, CC Chen |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
|
Bradykinin stimulates MMP-2 production in guinea pig tracheal smooth muscle cells
Ewa Zaczynska, Bichoy H Gabra, Pierre Sirois |
Inflammation | 2003 |
|
Prostaglandin E 2 Inhibits IL-18-Induced ICAM-1 and B7.2 Expression Through EP2/EP4 Receptors in Human Peripheral Blood Mononuclear Cells
HK Takahashi, H Iwagaki, T Yoshino, S Mori, T Morichika, H Itoh, M Yokoyama, S Kubo, E Kondo, T Akagi, N Tanaka, M Nishibori |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
|
Developmental Changes in Cyclooxygenase mRNA Expression in the Gastric Mucosa of Rats
T Tomomasa, T Ogawa, A Hikima, M Tabata, H Kaneko, A Morikawa |
Journal of Pediatric Gastroenterology and Nutrition | 2002 |
|
Epidural injection of cyclooxygenase-2 inhibitor attenuates pain-related behavior following application of nucleus pulposus to the nerve root in the rat
M Kawakami, T Matsumoto, H Hashizume, K Kuribayashi, T Tamaki |
Journal of Orthopaedic Research | 2002 |
|
Food-dependent exercise-induced anaphylaxis: influence of concurrent aspirin administration on skin testing and provocation
M Aihara, M Miyazawa, H Osuna, K Tsubaki, T Ikebe, Y Aihara, Z Ikezawa |
British Journal of Dermatology | 2002 |
|
Developmental changes in cyclo-oxygenase mRNA induction by hypoxia in rat kidney
T Ogawa, T Tomomasa, A Morikawa |
Pediatrics International | 2002 |
|
The role of prostaglandin E2 in the immunopathogenesis of experimental pulmonary tuberculosis
JR Moreno, IE García, MD la Hernández, DA Leon, R Marquez, RH Pando |
Immunology | 2002 |
|
Prostaglandin E2 down-regulates viable Bacille Calmette-Guérin-induced macrophage cytotoxicity against murine bladder cancer cell MBT-2 in vitro
H Yamada, E Kuroda, S Matsumoto, T Matsumoto, T Yamada, U Yamashita |
Clinical & Experimental Immunology | 2002 |
|
Induction of thromboxane A2 synthesizing enzymes in DMSO-induced granulocytic differentiation of HL-60 cells
M Zaitsu, E Ishii, Y Hamasaki |
Prostaglandins Leukotrienes and Essential Fatty Acids | 2002 |
|
Prostaglandin E2 production and induction of prostaglandin endoperoxide synthase-2 is inhibited in a murine macrophage-like cell line, RAW 264.7, by Mallotus japonicus phloroglucinol derivatives
R Ishii, M Horie, K Saito, M Arisawa, S Kitanaka |
Biochimica et Biophysica Acta (BBA) - General Subjects | 2002 |
|
Distinct functions of COX-1 and COX-2
I Morita |
Prostaglandins & Other Lipid Mediators | 2002 |
|
Handbook of the Autonomic Nervous System in Health and Disease
S Rivest |
Handbook of the Autonomic Nervous System in Health and Disease | 2002 |
|
Dendritic cells produce eicosanoids, which modulate generation and functions of antigen-presenting cells
H Harizi, N Gualde |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2002 |
|
Enhancement of lipopolysaccharide-stimulated cyclooxygenase-2 mRNA expression and prostaglandin E2 production in gingival fibroblasts from individuals with Down syndrome
Y Otsuka, M Ito, M Yamaguchi, S Saito, K Uesu, K Kasai, Y Abiko, J Mega |
Mechanisms of Ageing and Development | 2002 |
|
NCX-4016 (NO-Aspirin) Inhibits Lipopolysaccharide-Induced Tissue Factor Expression In Vivo: Role of Nitric Oxide
S Fiorucci, A Mencarelli, A Meneguzzi, A Lechi, A Morelli, P del Soldato, P Minuz |
Circulation | 2002 |
|
Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice
CB Keerthisingam, RG Jenkins, NK Harrison, NA Hernandez-Rodriguez, H Booth, GJ Laurent, SL Hart, ML Foster, RJ McAnulty |
The American Journal of Pathology | 2001 |
|
Expression of cyclooxygenase isoforms in normal human skin and chronic venous ulcers
SA Abd-El-Aleem, MW Ferguson, I Appleton, A Bhowmick, CN McCollum, GW Ireland |
The Journal of Pathology | 2001 |
|
NCX4016 (NO-Aspirin) has multiple inhibitory effects in LPS-stimulated human monocytes
P Minuz, M Degan, S Gaino, A Meneguzzi, V Zuliani, CL Santonastaso, PD Soldato, A Lechi |
British Journal of Pharmacology | 2001 |
|
Induction of cyclooxygenase-2 protein by lipoteichoic acid fromStaphylococcus aureusin human pulmonary epithelial cells: involvement of a nuclear factor-κB-dependent pathway
CH Lin, IH Kuan, HM Lee, WS Lee, JR Sheu, YS Ho, CH Wang, HP Kuo |
British Journal of Pharmacology | 2001 |
|
Increased expression of cyclooxygenase-2 in human salivary gland tumors
K Sakurai, M Urade, K Noguchi, H Kishimoto, M Ishibashi, H Yasoshima, T Yamamoto, A Kubota |
Pathology International | 2001 |
|
A study on cyclooxygenase -2 protein expression in esophageal caiconogenesis
L Wang, W Zhang, W Wang, H Wang, S Han, P Qü, Y Liu, M Li, B Liu, P Lin |
Chinese Journal of Cancer Research | 2001 |
|
Overlapping CRE and E-box promoter elements can independently regulate COX-2 gene transcription in macrophages
JR Mestre, DE Rivadeneira, PJ Mackrell, M Duff, PP Stapleton, V Mack-Strong, S Maddali, GP Smyth, T Tanabe, JM Daly |
FEBS Letters | 2001 |
|
Integrin-linked Kinase Regulates Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in an NF-κB-dependent Manner
C Tan, A Mui, S Dedhar |
The Journal of biological chemistry | 2001 |
|
How circulating cytokines trigger the neural circuits that control the hypothalamic–pituitary–adrenal axis
S Rivest |
Psychoneuroendocrinology | 2001 |
|
The Expression of Prostaglandin E Receptors EP 2 and EP 4 and Their Different Regulation by Lipopolysaccharide in C3H/HeN Peritoneal Macrophages
R Ikegami, Y Sugimoto, E Segi, M Katsuyama, H Karahashi, F Amano, T Maruyama, H Yamane, S Tsuchiya, A Ichikawa |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
|
Expression of Cyclooxygenase Enzymes in Rat Hypothalamo-Pituitary-Adrenal Axis: Effects of Endotoxin and Glucocorticoids
PO Cover, D Slater, JC Buckingham |
Endocrine | 2001 |
|
Regulated expression of both cyclooxygenase (COX) isoforms in a human model of inflammation: effects on generation of eicosanoids and isoeicosanoids in vivo
B.F. McAdam, I.A. Mardini, A. Habib, A. Burke, J.A. Lawson, S. Kapoor, G.A. FitzGerald |
Journal of Clinical Investigation | 2000 |
|
Expression of cyclooxygenase-2 in prostate carcinoma
R Yoshimura, H Sano, C Masuda, M Kawamura, Y Tsubouchi, J Chargui, N Yoshimura, T Hla, S Wada |
Cancer | 2000 |
|
Cox-2 and osteopontin in cocultured platelets and mesangial cells: Role of glucocorticoids
M Goppelt-Struebe, T Wiedemann, J Heusinger-Ribeiro, M Vucadinovic, M Rehm, F Prols |
Kidney International | 2000 |
|
Rat Pulmonary Cyclooxygenase-2 Expression in Response to Endotoxin Challenge
L Ermert, M Ermert, M Merkle, M Goppelt-Struebe, HR Duncker, F Grimminger, W Seeger |
The American Journal of Pathology | 2000 |
|
Localization of Cyclooxygenase-2 in Human Sporadic Colorectal Adenomas
KS Chapple, EJ Cartwright, G Hawcroft, A Tisbury, C Bonifer, N Scott, AC Windsor, PJ Guillou, AF Markham, PL Coletta, MA Hull |
The American Journal of Pathology | 2000 |
|
Selenoorganic compound, ebselen, inhibits nitric oxide and tumor necrosis factor-? production by the modulation of Jun-N-terminal kinase and the NF-?b signaling pathway in rat Kupffer cells
N Shimohashi, M Nakamuta, K Uchimura, R Sugimoto, H Iwamoto, M Enjoji, H Nawata |
Journal of Cellular Biochemistry | 2000 |
|
Cyclo-oxygenase isoenzymes: physiological and pharmacological role
PC Kam, AU See |
Anaesthesia | 2000 |
|
Lipid mediators in the pathophysiology of critical illness
EM Bulger, RV Maier |
Critical Care Medicine | 2000 |
|
Cyclooxygenase-2-Dependent Prostaglandin Production by Peripheral Blood Monocytes Stimulated With Lipopolysaccharides Isolated From Periodontopathogenic Bacteria
K Noguchi, M Yanai, M Shitashige, T Nishihara, I Ishikawa |
Journal of Periodontology | 2000 |
|
In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs
P Kay-Mugford, SJ Benn, J LaMarre, P Conlon |
American Journal of Veterinary Research | 2000 |
|
Prostaglandins Regulate Melanoma-Induced Cytokine Production in Macrophages
CA Eisengart, JR Mestre, HA Naama, PJ Mackrell, DE Rivadeneira, EM Murphy, PP Stapleton, JM Daly |
Cellular Immunology | 2000 |
|
Redundancy in the Signaling Pathways and Promoter Elements Regulating Cyclooxygenase-2 Gene Expression in Endotoxin-treated Macrophage/Monocytic Cells
JR Mestre, PJ Mackrell, DE Rivadeneira, PP Stapleton, T Tanabe, JM Daly |
The Journal of biological chemistry | 2000 |
|
Prolonged Exposure to Lipopolysaccharide Inhibits Macrophage 5-Lipoxygenase Metabolism Via Induction of Nitric Oxide Synthesis
MJ Coffey, SM Phare, M Peters-Golden |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
|
TNF-α-Induced Cyclooxygenase-2 Expression in Human Lung Epithelial Cells: Involvement of the Phospholipase C-γ2, Protein Kinase C-α, Tyrosine Kinase, NF-κB-Inducing Kinase, and I-κB Kinase 1/2 Pathway
CC Chen, YT Sun, JJ Chen, KT Chiu |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
|
New induction of leukotriene A4 hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes
M Zaitsu, Y Hamasaki, M Matsuo, A Kukita, K Tsuji, M Miyazaki, R Hayasaki, E Muro, S Yamamoto, I Kobayashi, T Ichimaru, O Kohashi, S Miyazaki |
Blood | 2000 |
|
Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus
SA Litherland, XT Xie, AD Hutson, C Wasserfall, DS Whittaker, JX She, A Hofig, MA Dennis, K Fuller, R Cook, D Schatz, LL Moldawer, MJ Clare-Salzler |
Journal of Clinical Investigation | 1999 |
|
Induction of cytosolic phospholipase A2 and prostaglandin H2 synthase-2 by ipopolysaccharide in human polymorphonuclear leukocytes
M Zaitsu, Y Hamasaki, M Matsuo, M Miyazaki, R Hayasaki, E Muro, S Yamamoto, I Kobayashi, T Ichimaru, S Miyazaki |
European Journal of Haematology | 1999 |
|
Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation
F Nantel, D Denis, R Gordon, A Northey, M Cirino, KM Metters, CC Chan |
British Journal of Pharmacology | 1999 |
|
Involvement of Cyclooxygenase-2 in Interleukin-1α-Induced Prostaglandin Production by Human Periodontal Ligament Cells
K Noguchi, M Shitashige, I Ishikawa |
Journal of Periodontology | 1999 |
|
Cyclooxygenase-2 is essential for normal recovery from 5-fluorouracil–induced myelotoxicity in mice
M Lorenz, HS Slaughter, DM Wescott, SI Carter, B Schnyder, JE Dinchuk, BD Car |
Experimental Hematology | 1999 |
|
Intracellular Measurement of Prostaglandin E2: Effect of Anti-inflammatory Drugs on Cyclooxygenase Activity and Prostanoid Expression
JK Horton, AS Williams, Z Smith-Phillips, RC Martin, G O'Beirne |
Analytical Biochemistry | 1999 |
|
Immunolocalization of cyclooxygenase-2 in the macula densa of human elderly
F Nantel, E Meadows, D Denis, B Connolly, KM Metters, A Giaid |
FEBS Letters | 1999 |
|
Synergy between cyclo-oxygenase-2 induction and arachidonic acid supply in vivo: consequences for nonsteroidal antiinflammatory drug efficacy
LC Hamilton, JA Mitchell, AM Tomlinson, TD Warner |
The FASEB Journal | 1999 |
|
Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity
MM Monick, AB Carter, GW Hunninghake |
The Journal of biological chemistry | 1999 |
|
Bacterial Lipopolysaccharide Induction of the Prostaglandin G/H Synthase 2 Gene Causes Thromboxane-Dependent Pulmonary Hypertension in Rabbits
P Delong, MG O'Sullivan, E Huggins, CL Hubbard, C McCall |
American journal of respiratory cell and molecular biology | 1999 |
|
Immunocytochemical localization of cyclo-oxygenase isoforms in cultured human airway structural cells
D K Petkova, L Pang, S P Range, E Holland, A J Knox |
Cell | 1999 |
|
Prostaglandin-endoperoxide H Synthase-2 Expression in Human Thyroid Epithelium: EVIDENCE FOR CONSTITUTIVE EXPRESSION IN VIVO AND IN CULTURED KAT-50 CELLS
TJ Smith, TA Jennings, D Sciaky, HJ Cao |
The Journal of biological chemistry | 1999 |
|
Leukoregulin upregulation of prostaglandin endoperoxide H synthase-2 expression in human orbital fibroblasts
HJ Cao, TJ Smith |
American journal of physiology. Cell physiology | 1999 |
|
HMC-1 Mast Cells Activate Human Orbital Fibroblasts in Coculture: Evidence for Up-Regulation of Prostaglandin E2 and Hyaluronan Synthesis*
TJ Smith, SJ Parikh |
Endocrinology | 1999 |
|
Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2.
McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, FitzGerald GA |
Proceedings of the National Academy of Sciences | 1999 |
|
Neue nichtsteroidale Antirheumatika: Selektive Hemmstoffe der induzierbaren Cyclooxygenase
DO Stichtenoth, H Zeidler, JC Frölich |
Medizinische Klinik | 1998 |
|
Induction of cyclooxygenase-2 causes an enhancement of writhing response in mice
H Matsumoto, H Naraba, A Ueno, T Fujiyoshi, M Murakami, I Kudo, S Oh-ishi |
European Journal of Pharmacology | 1998 |
|
The COX-1/COX-2 balance in asthma
Pang, Pitt, Petkova, Knox |
Clinical & Experimental Allergy | 1998 |
|
Signaling pathways mediating induction of the early response genes prostaglandin G/H synthase-2 and egr-1 by serotonin via 5-HT2A receptors
M Goppelt-Struebe, M Stroebel |
Journal of Cellular Physiology | 1998 |
|
Cyclooxygenase-1 and Cyclooxygenase-2 Selectivity of Widely Used Nonsteroidal Anti-Inflammatory Drugs
B Cryer |
The American Journal of Medicine | 1998 |
|
Cyclooxygenase-2 expression in human monocytes stimulated by meconium
PJ Uotila, PO Kääpä |
The Lancet | 1998 |
|
The advent of highly selective inhibitors of cyclooxygenase—a review
B Cryer, A Duboisø |
Prostaglandins & Other Lipid Mediators | 1998 |
|
Effect of Ciliary Neurotrophic Factor on Body Temperature and Cerebrospinal Fluid Prostanoids in the Cat
ES Akarsu, I Bishai, F Coceani |
Brain Research Bulletin | 1998 |
|
Expression of mRNAs for vasopressin, oxytocin and corticotrophin releasing hormone in the hypothalamus, and of cyclooxygenases-1 and -2 in the cerebral vasculature, of endotoxinchallenged pigs
SV Vellucci, RF Parrott |
Neuropeptides | 1998 |
|
Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4
T Endo, F Ogushi, T Kawano, S Sone |
Journal of immunology (Baltimore, Md. : 1950) | 1998 |
|
Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4
T Endo, F Ogushi, T Kawano, S Sone |
Journal of immunology (Baltimore, Md. : 1950) | 1998 |
|
Cyclooxygenase Isoenzyme Localization and mRNA Expression in Rat Lungs
L Ermert, M Ermert, M Goppelt-Struebe, D Walmrath, F Grimminger, W Steudel, HA Ghofrani, C Homberger, HR Duncker, W Seeger |
American journal of respiratory cell and molecular biology | 1998 |
|
MAP Kinase Pathways as a Route for Regulatory Mechanisms of IL-10 and IL-4 Which Inhibit COX-2 Expression in Human Monocytes
H Niiro, T Otsuka, E Ogami, K Yamaoka, S Nagano, M Akahoshi, H Nakashima, Y Arinobu, K Izuhara, Y Niho |
Biochemical and Biophysical Research Communications | 1998 |
|
Activation of Human Orbital Fibroblasts through CD40 Engagement Results in a Dramatic Induction of Hyaluronan Synthesis and Prostaglandin Endoperoxide H Synthase-2 Expression: INSIGHTS INTO POTENTIAL PATHOGENIC MECHANISMS OF THYROID-ASSOCIATED OPHTHALMOPATHY
HJ Cao, HS Wang, Y Zhang, HY Lin, RP Phipps, TJ Smith |
The Journal of biological chemistry | 1998 |
|
Profile of JTE-522 as a Human Cyclooxygenase-2 Inhibitor
K Wakitani, T Nanayama, M Masaki, M Matsushita |
The Japanese Journal of Pharmacology | 1998 |
|
Subcellular Localization of Prostaglandin Endoperoxide H Synthases-1 and -2 by Immunoelectron Microscopy
AG Spencer, JW Woods, T Arakawa, II Singer, WL Smith |
The Journal of biological chemistry | 1998 |
|
Expression and Vascular Effects of Cyclooxygenase-2 in Brain
JE Brian, SA Moore, FM Faraci |
Stroke; a journal of cerebral circulation | 1998 |
|
A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes
JC Frölich |
Trends in Pharmacological Sciences | 1997 |
|
Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages
JK Elmquist, CD Breder, JE Sherin, TE Scammell, WF Hickey, D Dewitt, CB Saper |
The Journal of Comparative Neurology | 1997 |
|
Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type
MG Belvisi, MA Saunders, EB Haddad, SJ Hirst, MH Yacoub, PJ Barnes, JA Mitchell |
British Journal of Pharmacology | 1997 |
|
Effect of interleukin-1β, tumour necrosis factor-αand interferon-γ on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells
L Pang, AJ Knox |
British Journal of Pharmacology | 1997 |
|
Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors
R Yamazaki, S Kawai, T Matsuzaki, N Kaneda, S Hashimoto, T Yokokura, R Okamoto, T Koshino, Y Mizushima |
European Journal of Pharmacology | 1997 |
|
Differential Sensitivities of Human Blood Monocytes and Alveolar Macrophages to the Inhibition of Prostaglandin Endoperoxide Synthase-2 by Interleukin-4
R Dworski, JR Sheller |
Prostaglandins | 1997 |
|
Isoenzyme-specific cyclooxygenase inhibitors: A whole cell assay system using the human erythroleukemic cell line HEL and the human monocytic cell line Mono Mac 6
J Berg, T Christoph, M Widerna, A Bodenteich |
Journal of Pharmacological and Toxicological Methods | 1997 |
|
Tumor Necrosis Factor-α Inversely Regulates Prostaglandin D 2 and Prostaglandin E 2 Production in Murine Macrophages: SYNERGISTIC ACTION OF CYCLIC AMP ON CYCLOOXYGENASE-2 EXPRESSION AND PROSTAGLANDIN E 2 SYNTHESIS
T Fournier, V Fadok, PM Henson |
The Journal of biological chemistry | 1997 |
|
Side Effects of Anti-Inflammatory Drugs IV
KD Rainsford |
1997 | |
|
Regulation by Interleukin-10 and Interleukin-4 of Cyclooxygenase-2 Expression in Human Neutrophils
H Niiro, T Otsuka, K Izuhara, K Yamaoka, K Ohshima, T Tanabe, S Hara, Y Nemoto, Y Tanaka, H Nakashima, Y Niho |
Blood | 1997 |
|
Effect of topically applied cyclooxygenase-2-selective inhibitors on arachidonic acid- and tetradecanoylphorbol acetate-induced dermal inflammation in the mouse
V Puigneró, J Queralt |
Inflammation | 1997 |
|
Human whole blood assays for inhibition of prostaglandin G/H synthases-1 and-2 using A23187 and lipopolysaccharide stimulation of thromboxane B2 production
JM Young, S Panah, C Satchawatcharaphong, PS Cheung |
Inflammation Research | 1996 |
|
Distinct isoforms (COX-1 and COX-2) of cyclooxygenase: possible physiological and therapeutic implications
M Pairet, G Engelhardt |
Fundamental & Clinical Pharmacology | 1996 |
|
Prostaglandin synthase 2
H Herschman |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1996 |
|
Differential inhibition of cyclooxygenase-1 (COX-1) and-2 (COX-2) by NSAIDS: Consequences on anti-inflammatory activity versus gastric and renal safety
M Pairet, L Churchill, G Trummlitz, G Engelhardt |
Inflammopharmacology | 1996 |
|
Endotoxin induces the expression of prostaglandin H synthase-2 and eicosanoid formation in cells of the human monocytic cell line Mono Mac 6
T Christoph, M Widerna, A Bodenteich, J Berg |
Inflammopharmacology | 1996 |
|
Effect of in vitro aging on Campylobacter rectus lipopolysaccharide-stimulated PGE2 release from human gingival fibroblasts
H Takiguchi, M Yamaguchi, K Mochizuki, Y Abiko |
Oral Diseases | 1996 |
|
Cyclooxygenase-2 and its regulation in inflammation
YS Bakhle, RM Botting |
Mediators of Inflammation | 1996 |
|
Down-regulation of cyclooxygenase-2 (COX-2) by interleukin-1 receptor antagonist in human monocytes
E Porreca, M Reale, CD Febbo, MD Gioacchino, RC Barbacane, ML Castellani, G Baccante, P Conti, F Cuccurullo |
Immunology | 1996 |
|
Induction of prostaglandin endoperoxide synthase-2 in human monocytes associated with cyclo-oxygenase-dependent F2-isoprostane formation
P Patrignani, G Santini, MR Panara, MG Sciulli, A Greco, MT Rotondo, M Giamberardino, J Maclouf, G Ciabattoni, C Patrono |
British Journal of Pharmacology | 1996 |
|
Taurine chloramine inhibits prostaglandin E2 production in activated raw 264.7 cells by post-transcriptional effects on inducible cyclooxygenase expression
MR Quinn, E Park, G Schuller-Levis |
Immunology Letters | 1996 |
|
Bacterial Endotoxin Primes the Human Alveolar Macrophage for Subsequent Stimulation by Silica but Silica Does Not Prime for Stimulation by Bacterial Endotoxin
LM Demers, LJ Gaydos, JL Stauffer, DC Kuhn |
Applied Occupational and Environmental Hygiene | 1996 |
|
Modulation of tumor necrosis factor-α release by anisoosmolarity and betaine in rat liver macrophages (Kupffer cells)
F Zhang, U Warskulat, D Häussinger |
FEBS Letters | 1996 |
|
Modulation of phagocytosis by anisoosmolarity and betaine in rat liver macrophages (Kupffer cells) and RAW 264.7 mouse macrophages
U Warskulat, F Zhang, D Häussinger |
FEBS Letters | 1996 |
|
Cytokine induction of cytosolic phospholipase A2 and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells
R Newton, LM Kuitert, DM Slater, IM Adcock, PJ Barnes |
Life Sciences | 1996 |
|
Leukoregulin Induction of Prostaglandin-Endoperoxide H Synthase-2 in Human Orbital Fibroblasts: AN IN VITRO MODEL FOR CONNECTIVE TISSUE INFLAMMATION
HS Wang, HJ Cao, VD Winn, LJ Rezanka, Y Frobert, CH Evans, D Sciaky, DA Young, TJ Smith |
The Journal of biological chemistry | 1996 |
|
Cyclooxygenase-2-Dependent Bronchoconstriction in Perfused Rat Lungs Exposed to Endotoxin
S Uhlig, R Nüsing, A von Bethmann, RL Featherstone, T Klein, F Brasch, KM Müller, V Ullrich, A Wendel |
Molecular Medicine | 1996 |
|
Eicosanoids
GC Folco, B Samuelsson, J Maclouf, GP Velo |
1996 | |
|
Prostaglandin production via induction of cyclooxygenase-2 by human gingival fibroblasts stimulated with lipopolysaccharides
K Noguchi, M Shitashige, M Yanai, I Morita, T Nishihara, S Murota, I Ishikawa |
Inflammation | 1996 |
|
Eicosanoid mediator expression in mononuclear and polymorphonuclear cells in normal subjects and patients with atopic asthma and cystic fibrosis
LM Kuitert, R Newton, NC Barnes, IM Adcock, PJ Barnes |
Thorax | 1996 |
|
New Targets in Inflammation
N Bazan, J Botting, J Vane |
1996 | |
|
A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors
C Brideau, S Kargman, S Liu, AL Dallob, EW Ehrich, IW Rodger, |
Inflammation Research | 1996 |
|
Cyclooxygenase-2: Regulation and relevance in inflammation
J Mitchell |
Biochemical Pharmacology | 1995 |
|
Interleukin-4 inhibits lipopolysaccharide-induced expression of prostaglandin H synthase-2 in human alveolar macrophages
T Yano, HA Hopkins, SL Hemplel, M Monick, GW Hunninghake |
Journal of Cellular Physiology | 1995 |
|
Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response
C Cao, K Matsumura, K Yamagata, Y Watanabe |
Brain Research | 1995 |
|
new insights into prostaglandins and mucosal defence
JL Wallace, AW Tigley |
Alimentary Pharmacology & Therapeutics | 1995 |
|
Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions
J Clària, CN Serhan |
Proceedings of the National Academy of Sciences | 1995 |
|
Effects of the novel anti-inflammatory compounds, N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulphonamide (NS-398) and 5-methanesulphonamido-6-(2,4-difluorothio-phenyl)-1-inda none (L-745,337), on the cyclo-oxygenase activity of human blood prostaglandin endoperoxide synthases
MR Panara, A Greco, G Santini, MG Sciulli, MT Rotondo, R Padovano, M Giamberardino, F Cipollone, F Cuccurullo, C Patrono |
British Journal of Pharmacology | 1995 |
|
Hyperosmolarity stimulates prostaglandin synthesis and cyclooxygenase-2 expression in activated rat liver macrophages
F Zhang, U Warskulat, M Wettstein, R Schreiber, HP Henninger, K Decker, D Häussinger |
Biochemical Journal | 1995 |
|
Regulation of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme expression
M Goppelt-Struebe |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 1995 |
|
Regulation of two isozymes of prostaglandin endoperoxide synthase and thromboxane synthase in human monoblastoid cell line U937
T Nanayama, S Hara, H Inoue, C Yokoyama, T Tanabe |
Prostaglandins | 1995 |
|
Section Review: Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Development of NSAIDs with reduced gastrointestinal and renal toxicity
JL Wallace, PD Soldato, G Cirino |
Expert Opinion on Investigational Drugs | 1995 |
|
The development of gastrointestinal-sparing nonsteroidal anti-inflammatory drugs
JL Wallace, G Cirino |
Trends in Pharmacological Sciences | 1994 |
|
Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone
JA Mitchell, MG Belvisi, P Akarasereenont, RA Robbins, OJ Kwon, J Croxtall, PJ Barnes, JR Vane |
British Journal of Pharmacology | 1994 |
|
The cyclic AMP response element plays an essential role in the expression of the human prostaglandin-endoperoxide synthase 2 gene in differentiated U937 monocytic cells
H Inoue, T Nanayama, S Hara, C Yokoyama, T Tanabe |
FEBS Letters | 1994 |
|
Synthesis of prostaglandin H synthase-2 by human alveolar macrophages in response to lipopolysaccharide is inhibited by decreased cell oxidant tone
SL Hempel, MM Monick, B He, T Yano, GW Hunninghake |
The Journal of biological chemistry | 1994 |
|
The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs
GD Anderson, SD Hauser, KL McGarity, ME Bremer, PC Isakson, SA Gregory |
Journal of Clinical Investigation | 1981 |
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The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs
GD Anderson, SD Hauser, KL McGarity, ME Bremer, PC Isakson, SA Gregory |
Journal of Clinical Investigation | 1981 |
|
Alteration of canine renal vascular response to hemorrhage by inhibitors of prostaglandin synthesis
BF McAdam, F Catella-Lawson, IA Mardini, S Kapoor, JA Lawson, GA FitzGerald |
The American journal of physiology | 1976 |
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Alteration of canine renal vascular response to hemorrhage by inhibitors of prostaglandin synthesis
BF McAdam, F Catella-Lawson, IA Mardini, S Kapoor, JA Lawson, GA FitzGerald |
The American journal of physiology | 1976 |
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