The current study examined whether alterations in glucocorticoid receptor (GR) binding contribute to poor response to glucocorticoid therapy in asthma. 29 asthma patients with forced expiratory volume in 1 s (FEV1) < 70% predicted were studied. Patients were classified as steroid sensitive (SS) if their morning FEV1 increased > 30% after a 1-wk course of oral prednisone 20 mg twice daily and steroid resistant (SR) if they failed to increase > 15%. PBMC obtained from these two groups, 17 SR and 12 SS, as well as 12 normal controls were analyzed. SR patients had two distinguishable GR binding abnormalities: 15 of the 17 SR patients demonstrated a significantly reduced GR binding affinity, as compared with SS patients (P = 0.0001) and normal controls (P = 0.0001). This defect was localized to T cells and reverted to normal after 48 h in culture media. However, incubation with a combination of IL-2 and IL-4 sustained this abnormality. The other two SR patients had an abnormally low GR number with normal binding affinity that was not limited to T cells. Furthermore, GR number failed to normalize after incubation in media alone or IL-2 and IL-4. Therefore, SR asthma may be due to more than one abnormality, the majority related to a reversible cytokine-induced reduction in GR binding affinity and the second related to an irreversible reduction in GR number. These findings may have important implications for the design of alternative treatment approaches for recalcitrant asthma.
E R Sher, D Y Leung, W Surs, J C Kam, G Zieg, A K Kamada, S J Szefler
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The Acth Axis: Pathogenesis, Diagnosis and Treatment
RC Gaillard |
2003 | |
Glucocorticoid-resistant asthma
TK Loke, AR Sousa, CJ Corrigan, TH Lee |
Current Allergy and Asthma Reports | 2002 |
Bronchial inflammation in corticosteroid-sensitive and corticosteroid-resistant asthma at baseline and on oral corticosteroid treatment
J Chakir, Q Hamid, M Bosse, LP Boulet, M Laviolette |
Clinical & Experimental Allergy | 2002 |
Advances in the development of genetic markers for the diagnosis of disease and drug response
E Halapi, H Hakonarson |
Expert Review of Molecular Diagnostics | 2002 |
Childhood Asthma as an Allergic Disease: Basis of Anti-Immunoglobulin E Therapy
H Milgrom |
Pediatric Asthma, Allergy & Immunology | 2002 |
Glucocorticoid receptor variants: clinical implications
RH DeRijk, M Schaaf, ER Kloet |
The Journal of Steroid Biochemistry and Molecular Biology | 2002 |
Expression of c-fos, rather than c-jun or glucocorticoid-receptor mRNA, correlates with decreased glucocorticoid response of peripheral blood mononuclear cells in asthma
E Takahashi, K Onda, T Hirano, K Oka, N Maruoka, M Tsuyuguchi, Y Matsumura, T Niitsuma, T Hayashi |
International Immunopharmacology | 2002 |
Refractory asthma
M McGeehan, WW Busse |
Medical Clinics of North America | 2002 |
p38 Mitogen-activated protein kinase–induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma
E Irusen, JG Matthews, A Takahashi, PJ Barnes, KF Chung, IM Adcock |
Journal of Allergy and Clinical Immunology | 2002 |
Prolonged methylprednisolone treatment suppresses systemic inflammation in patients with unresolving acute respiratory distress syndrome: evidence for inadequate endogenous glucocorticoid secretion and inflammation-induced immune cell resistance to glucocorticoids
GU Meduri, EA Tolley, GP Chrousos, F Stentz |
American journal of respiratory and critical care medicine | 2002 |
IgE and Anti-IgE Therapy in Asthma and Allergic Disease
D Dombrowicz, A Capron, M Capro |
IgE and Anti-IgE Therapy in Asthma and Allergic Disease: Pathogenesis and Novel Therapeutic Strategies | 2002 |
L’asthme difficile de l’enfant
C Iliescu, I Tillie-Leblond, A Deschildre, J Blic |
Archives de Pédiatrie | 2002 |
Respuesta al tratamiento glucocorticoideo en el asma. Papel de las isoformas α y β del receptor glucocorticoideo
A Torrego, L Pujols, C Picado |
Archivos de Bronconeumología | 2002 |
Prior bowel resections, perianal disease, and a high initial Crohn's disease activity index are associated with corticosteroid resistance in active Crohn's disease
CM Gelbmann, G Rogler, V Gross, M Gierend, N Bregenzer, T Andus, J Scholmerich |
The American Journal of Gastroenterology | 2002 |
A Role for STAT5 in the Pathogenesis of IL-2-Induced Glucocorticoid Resistance
E Goleva, KO Kisich, DY Leung |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Difficult asthma: Defining the problems
SC Ranganathan, DN Payne, A Jaffe, SA McKenzie |
Pediatric Pulmonology | 2001 |
Stress Response, Tachykinin, and Cutaneous Inflammation
I Katayama, SJ Bae, Y Hamasaki, K Igawa, Y Miyazaki, H Yokozeki, K Nishioka |
Journal of Investigative Dermatology Symposium Proceedings | 2001 |
The phase-shift mutation in the glucocorticoid receptor gene: potential etiologic significance of neuroendocrine mechanisms in lupus nephritis
T Jiang, S Liu, M Tan, F Huang, Y Sun, X Dong, W Guan, L Huang, F Zhou |
Clinica Chimica Acta | 2001 |
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
CM Pariante, AH Miller |
Biological Psychiatry | 2001 |
Neuroimmune alterations in the complex regional pain syndrome
FJ Huygen, AG de Bruijn, J Klein, FJ Zijlstra |
European Journal of Pharmacology | 2001 |
Effect of Glucocorticoid Therapy on Glucocorticoid Receptors in Children with Autoimmune Diseases
J Andreae, R Tripmacher, R Weltrich, W Rohde, R Keitzer, U Wahn, K Paul, F Buttgereit |
Pediatric Research | 2001 |
DIFFERENTIAL DIAGNOSIS IN THE DIFFICULT ASTHMATIC
MV White |
Immunology and Allergy Clinics of North America | 2001 |
Decreased steroid responsiveness at night in nocturnal asthma. Is the macrophage responsible?
M Kraft, Q Hamid, GP Chrousos, RJ Martin, DY Leung |
American journal of respiratory and critical care medicine | 2001 |
Lung Biology in Health and Disease: Pathogenesis and Clinical Management
R Ballard |
Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential | 2001 |
Gene Therapy for Acute and Acquired Diseases
P Factor |
2001 | |
Current understanding and problems of steroid- resistant asthma
A Mori |
Allergology International | 2000 |
Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity
AJ Sandford, T Chagani, S Zhu, TD Weir, TR Bai, JJ Spinelli, JM FitzGerald, NA Behbehani, WC Tan, PD Paré |
Journal of Allergy and Clinical Immunology | 2000 |
Association and Linkage of Atopic Dermatitis with Chromosome 13q12-14 and 5q31-33 Markers
K Beyer, R Nickel, L Freidhoff, B Bjorksten, SK Huang, KC Barnes, S MacDonald, J Forster, F Zepp, V Wahn, TH Beaty, DG Marsh, U Wahn |
Journal of Investigative Dermatology | 2000 |
Prediction of treatment refractoriness in ulcerative colitis and Crohn's disease-do we have reliable markers?
CM Gelbmann |
Inflammatory Bowel Diseases | 2000 |
Tumour necrosis factor (TNF) gene polymorphism in Crohn's disease (CD): influence on disease behaviour?
E Louis, M Peeters, D Franchimont, L Seidel, F Fontaine, G Demolin, F Croes, P Dupont, L Davin, S Omri, P Rutgeerts, J Belaiche |
Clinical & Experimental Immunology | 2000 |
Resistance to glucocorticoid-induced apoptosis in PLP peptide-specific T cell clones from patients with progressive MS
J Correale, W Gilmore, S Li, J Walsh, MM Bassani, B Lund, M Arias, LP Weiner |
Journal of Neuroimmunology | 2000 |
Abnormal steroid responsiveness in atopic dermatitis patients: therapeutic implications
EN Charlesworth |
Annals of Allergy, Asthma & Immunology | 2000 |
Adrenocortical function in patients with severe atopic dermatitis
K Matsuda, T Katsunuma, Y Iikura, H Kato, H Saito, A Akasawa |
Annals of Allergy, Asthma & Immunology | 2000 |
Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform
AR Sousa, SJ Lane, JA Cidlowski, DZ Staynov, TH Lee |
Journal of Allergy and Clinical Immunology | 2000 |
Pathophysiology of severe asthma
WW Busse, S Banks-Schlegel, SE Wenzel |
Journal of Allergy and Clinical Immunology | 2000 |
Increased number of glucocorticoid receptor-β–expressing cells in the airways in fatal asthma
P Christodoulopoulos, DY Leung, MW Elliott, JC Hogg, S Muro, M Toda, S Laberge, QA Hamid |
Journal of Allergy and Clinical Immunology | 2000 |
Interactions between the hypothalamic-pituitary-adrenal axis and allergic inflammation
RP Schleimer |
Journal of Allergy and Clinical Immunology | 2000 |
Prediction of Treatment Refractoriness in Ulcerative Colitis and Crohnʼs Disease—Do We Have Reliable Markers?:
CM Gelbmann |
Inflammatory Bowel Diseases | 2000 |
Glucocorticoid Receptor α and β in Glucocorticoid Dependent Asthma
R Gagliardo, P Chanez, AM Vignola, J Bousquet, I Vachier, P Godard, G Bonsignore, P Demoly, M Mathieu |
American journal of respiratory and critical care medicine | 2000 |
Is there a role for glucocorticoid receptor beta in asthma?
R Gagliardo, AM Vignola, M Mathieu |
Respiratory Research | 2000 |
Syndromes of Severe Asthma
NM Kaplan, BF Palmer, JC Weissler |
The American Journal of the Medical Sciences | 2000 |
The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders
C Heim, U Ehlert, DH Hellhammer |
Psychoneuroendocrinology | 2000 |
Southwestern Internal Medicine Conference: Syndromes of Severe Asthma
JC Weissler |
The American Journal of the Medical Sciences | 2000 |
Higher expression of glucocorticoid receptor in peripheral mononuclear cells in inflammatory bowel disease
A Schottelius, S Wedel, R Weltrich, W Rohde, F Buttgereit, S Schreiber, H Lochs |
The American Journal of Gastroenterology | 2000 |
Five Patients with Biochemical and/or Clinical Generalized Glucocorticoid Resistance without Alterations in the Glucocorticoid Receptor Gene*
NA Huizenga, P de Lange, JW Koper, WW de Herder, R Abs, JH v. Kasteren, FH de Jong, SW Lamberts |
The Journal of clinical endocrinology and metabolism | 2000 |
Das therapieresistente Asthma
F Kummer, M Kneußl |
2000 | |
Nocturnal asthma is associated with reduced glucocorticoid receptor binding affinity and decreased steroid responsiveness at night
M Kraft, E Vianna, RJ Martin, DY Leung |
Journal of Allergy and Clinical Immunology | 1999 |
Mechanisms of glucocorticoid reduction in asthmatic subjects treated with intravenous immunoglobulin
JD Spahn, DY Leung, MT Chan, SJ Szefler, EW Gelfand |
Journal of Allergy and Clinical Immunology | 1999 |
IL-2 and IL-4 counteract budesonide inhibition of GM-CSF and IL-10, but not of IL-8, IL-12 or TNF-αproduction by human mononuclear blood cells
S Larsson, CG Löfdahl, M Linden |
British Journal of Pharmacology | 1999 |
An in vitro comparison of commonly used topical glucocorticoid preparations
C Stellato, J Atsuta, CA Bickel, RP Schleimer |
Journal of Allergy and Clinical Immunology | 1999 |
In vivo resistance to corticosteroids in bronchial asthma is associated with enhanced phosyphorylation of JUN N-terminal kinase and failure of prednisolone to inhibit JUN N-terminal kinase phosphorylation
AR Sousa, SJ Lane, C Soh, TH Lee |
Journal of Allergy and Clinical Immunology | 1999 |
Modulation by Cytokines of Glucocorticoid Action
A Angeli, RG Masera, ML Sartori, N Fortunati, S Racca, A Dovio, A Staurenghi, R Frairia |
Annals of the New York Academy of Sciences | 1999 |
Cytokines in asthma
KF Chung, PJ Barnes |
Thorax | 1999 |
Clinical outcomes of steroid-insensitive asthma
FS Wamboldt, JD Spahn, MD Klinnert, MZ Wamboldt, LA Gavin, SJ Szefler, DY Leung |
Annals of Allergy, Asthma & Immunology | 1999 |
CORTICOSTEROID-INSENSITIVE ASTHMA
DY Leung, SJ Szefler |
Immunology and Allergy Clinics of North America | 1999 |
CORTICOSTEROIDS IN THE TREATMENT OF SINUSITIS AND NASAL POLYPS
DL Hamilos |
Immunology and Allergy Clinics of North America | 1999 |
Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma
QA Hamid, SE Wenzel, PJ Hauk, A Tsicopoulos, B Wallaert, JJ Lafitte, GP Chrousos, SJ Szefler, DY Leung |
American journal of respiratory and critical care medicine | 1999 |
The glucocorticoid receptor gene as a candidate for gene therapy in asthma
M Mathieu, C Gougat, D Jaffuel, M Danielsen, P Godard, J Bousquet, P Demoly |
Gene Therapy | 1999 |
Resistência a corticosteroides**Trabalho apresentado em painel sobre "Resistencia a Fármacos" no XIV Congresso de Pneumologia (Viseu, 10.11.98)
JP Mendes |
Revista Portuguesa de Pneumologia | 1999 |
Hormone Resistance Syndromes
JL Jameson |
1999 | |
Glucocorticoid Resistance Caused by Reduced Expression of the Glucocorticoid Receptor in Cells From Human Vascular Lesions
PJ Bray, B Du, VM Mejia, SC Hao, E Deutsch, C Fu, RC Wilson, H Hanauske-Abel, TA McCaffrey |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
Anti-Inflammatory Drugs in Asthma
AP Sampson, MK Church |
1999 | |
Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB and Steroid Receptor-Signaling Pathways
LI McKay, JA Cidlowski |
Endocrine reviews | 1999 |
Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes
SJ Lane, IM Adcock, D Richards, C Hawrylowicz, PJ Barnes, TH Lee |
Journal of Clinical Investigation | 1998 |
Asthma
NB Pride |
Asthma | 1998 |
New insights into steroid resistant asthma
DY Leung, SJ Szefler |
Pediatric Allergy and Immunology | 1998 |
Mechanisms of Glucocorticoid-Resistant Asthmaa
DY Leung, M Castro, SJ Szefler, GP Chrousos |
Annals of the New York Academy of Sciences | 1998 |
Comprehensive Asthma Management: Guidelines for Clinicians
JP Kemp |
Journal of Asthma | 1998 |
Inhibition of interleukin-5 mediated eosinophil viability by fluticasone 17-propionate: comparison with other glucocorticoids
Hagan, Kita, Gleich |
Clinical & Experimental Allergy | 1998 |
Corticosteroid responsiveness and the evolution of asthma
Chung |
Clinical & Experimental Allergy | 1998 |
Corticosteroid unresponsiveness in asthma: Primary or acquired?
DN Payne, M Hubbard, SA McKenzie |
Pediatric Pulmonology | 1998 |
Serum Cortisol in Asthma: Marker of Nocturnal Worsening of Sysmptoms and Lung Function?
M Kraft, J Pak, RJ Martin |
Chronobiology International | 1998 |
Glucocorticoid receptor expression in human bronchial epithelial cells: effects of smoking and COPD
MM Verheggen, PW Adriaansen-Soeting, CA Berrevoets, PT van Hal, AO Brinkmann, HC Hoogsteden, MA Versnel |
Mediators of Inflammation | 1998 |
Molecular Basis of Allergic Diseases
DY Leung |
Molecular Genetics and Metabolism | 1998 |
Glucocorticoids Inhibit Proliferation and Interleukin-4 and Interleukin-5 Secretion by Aeroallergen-Specific T-Helper Type 2 Cell Lines
IC Crocker, MK Church, S Newton, RG Townley |
Annals of Allergy, Asthma & Immunology | 1998 |
Effects of dexamethasone on the profile of cytokine secretion in human whole blood cell cultures
D Franchimont, E Louis, W Dewe, H Martens, Y Vrindts-Gevaert, DD Groote, J Belaiche, V Geenen |
Regulatory Peptides | 1998 |
Fluticasone Propionate Results in Improved Glucocorticoid Receptor Binding Affinity and Reduced Oral Glucocorticoid Requirements in Severe Asthma
SR Nimmagadda, JD Spahn, HS Nelson, J Jenkins, SJ Szefler, DY Leung |
Annals of Allergy, Asthma & Immunology | 1998 |
Asthma and Allergic Diseases
WJ Metzger, JA Nyce |
Asthma and Allergic Diseases | 1998 |
Climatic factors and climatic therapy in asthma
H Razzouk, B Blaive, O Massot, D Charpin, D Vervloet |
Revue Française d'Allergologie et d'Immunologie Clinique | 1998 |
Individual variations in lymphocyte-responses to glucocorticoids in patients with bronchial asthma: comparison of potencies for five glucocorticoids
T Hirano, M Homma, K Oka, H Tsushima, T Niitsuma, T Hayashi |
Immunopharmacology | 1998 |
Efficacy and Safety of Inhaled Corticosteroids: New Developments
PJ Barnes, S Pedersen, WW Busse |
American journal of respiratory and critical care medicine | 1998 |
Glucocorticoid Receptors in Bronchial Epithelial Cells in Asthma
I Vachier, G Chiappara, AM Vignola, R Gagliardo, E Altieri, B Térouanne, P Vic, J Bousquet, P Godard, P Chanez |
American journal of respiratory and critical care medicine | 1998 |
Autoimmune Aspects of Lung Disease
DA Isenberg, SG Spiro |
1998 | |
Evaluation, Treatment, and Management of the Asthmatic Patient
SL Ruggiero |
Oral and Maxillofacial Surgery Clinics of North America | 1998 |
Relationship between glucocorticoid receptor and response to glucocorticoid therapy in ulcerative colitis
T Shimada, N Hiwatashi, H Yamazaki, Y Kinouchi, T Toyota |
Diseases of the Colon & Rectum | 1997 |
Corticosteroid Resistance and Disease
R Derijk, EM Sternberg |
Annals of Medicine | 1997 |
Role of T cells in asthma
AB Kay |
Allergology International | 1997 |
Immunologic Basis of Chronic Allergic Diseases: Clinical Messages from the Laboratory Bench
DY Leung |
Pediatric Research | 1997 |
Psychoendocrinological Observations in Women with Chronic Pelvic Pain
C Heim, U Ehlert, J Rexhausen, JP Hanker, DH Hellhammer |
Annals of the New York Academy of Sciences | 1997 |
Increased intra-abdominal fat deposition in patients with major depressive illness as measured by computed tomography
JH Thakore, PJ Richards, RH Reznek, A Martin, TG Dinan |
Biological Psychiatry | 1997 |
Topical glucocorticoid augments IgE-mediated passive cutaneous anaphylaxis in Balb/C mice and mast cell deficient WBB6F1 v/v mice
I Katayama, K Igawa, K Minatohara, K Nishioka |
Clinical & Experimental Allergy | 1997 |
Topical glucocorticoid augments both allergic and non-allergic cutaneous reactions in mice when applied at the afferent stage of contact sensitivity
K Igawa, I Katayama, K Minatohara, T Satoh, H Yokozeki, K Nishioka |
Allergology International | 1997 |
New Insights into the Pathogenesis and Management of Steroid-Resistant Asthma
JD Spahn, DY Leung, SJ Szefler |
Journal of Asthma | 1997 |
Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta
DY Leung, Q Hamid, A Vottero, SJ Szefler, W Surs, E Minshall, GP Chrousos, DJ Klemm |
Journal of Experimental Medicine | 1997 |
DIAGNOSIS AND MANAGEMENT OF STEROID-RESISTANT ASTHMA
DY Leung, SJ Szefler |
Clinics in Chest Medicine | 1997 |
Interleukin-2 and -4 induce resistance of granulocyte–macrophage colony-stimulating factor to corticosteroids
S Larsson, R Brattsand, M Linden |
European Journal of Pharmacology | 1997 |
Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor
DY Leung, Q Hamid, A Vottero, SJ Szefler, W Surs, E Minshall, GP Chrousos, DJ Klemm |
Journal of Experimental Medicine | 1997 |
The in vitro and in vivo effect of corticosteroides on basophi releasabihty in patients with mild and severe bronchial asthma
S Kivity, A Onn, O Agami, E Fireman |
Clinical & Experimental Allergy | 1997 |
Early parenteral corticosteroid administration in acute asthma
RY Lin, GR Pesola, RE Westfal, L Bakalchuk, CW Freyberg, D Cataquet, GT Heyl |
The American Journal of Emergency Medicine | 1997 |
Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number or affinity of glucocorticoid-receptors in chronic renal failure patients
T Hirano, A Horigome, K Oka, H Takeuchi, M Yoshida, E Sakurai, K Kozaki, N Matsuno, T Nagao, M Kozaki |
Immunopharmacology | 1997 |
Steroid Hormones and the T-Cell Cytokine Profile
GA Rook, S Lightman |
1997 | |
The Pediatric Lung
RW Wilmott |
1997 | |
Glucocorticoids and the Immune Function in the Human Immunodeficiency Virus Infection: A Study in Hypercortisolemic and Cortisol-Resistant Patients*
G Norbiato, M Bevilacqua, T Vago, A Taddei, M Clerici |
The Journal of clinical endocrinology and metabolism | 1997 |
Effects of prednisolone on bone turnover in patients with corticosteroid resistant asthma
SJ Lane, S Vaja, R Swaminathan, TH Lee |
Clinical & Experimental Allergy | 1996 |
Clinical aspects of glucocorticoid sensitivity
SW Lamberts, AT Huizenga, P Lange, FH Jong, JW Koper |
Steroids | 1996 |
Molecular basis of glucocorticoid-resistant syndromes
S Werner, M Brönnegård |
Steroids | 1996 |
Steroid-Resistant Asthma: Evaluation and Management
SR Nimmagadda, JD Spahn, DY Leung, SJ Szefler |
Annals of Allergy, Asthma & Immunology | 1996 |
TREATMENT OF STEROID-RESISTANT ASTHMA
DK Ledford |
Immunology and Allergy Clinics of North America | 1996 |
Induction of Corticosteroid Resistance In Vitro
DY Leung, JD Spahn, SR Nimmagadda, SJ Szefler |
American journal of respiratory and critical care medicine | 1996 |
Molecular Mechanisms of Clucocorticoid Resistance/Hypersensitivity: Potential Clinical Implications
GP Chrousos, M Castro, DY Leung, E Webster, T Kino, C Bamberger, S Elliot, C Stratakis, M Karl |
American journal of respiratory and critical care medicine | 1996 |
4. The Inflammatory Response
JA Denburg |
American journal of respiratory and critical care medicine | 1996 |
Pathology of Mild, Severe, and Fatal Asthma
AB Kay |
American journal of respiratory and critical care medicine | 1996 |
Glucocorticoid-resistant Asthma: T-lymphocyte Defects
CJ Corrigan |
American journal of respiratory and critical care medicine | 1996 |
Current Management of Asthma Patients with Corticosteroid Resistance
WW Busse, K McGill, NN Jarjour |
American journal of respiratory and critical care medicine | 1996 |
9. Why Does Asthma Become Persistent?
PJ Barnes, FW Liew |
American journal of respiratory and critical care medicine | 1996 |
12. How Do Steroids Work?
RP Schleimer |
American journal of respiratory and critical care medicine | 1996 |
Steroid Resistance in Asthma: Molecular Mechanisms
IM Adcock |
American journal of respiratory and critical care medicine | 1996 |
Mecanismos de acción de los glucocorticoides. Aplicación al tratamiento de la inflamación respiratoria
J Mullol, L Pujols, C Picado |
Archivos de Bronconeumología | 1996 |
The Non-Ligand Binding β-Isoform of the Human Glucocorticoid Receptor (hGRβ): Tissue Levels, Mechanism of Action, and Potential Physiologic Role
M de Castro, S Elliot, T Kino, C Bamberger, M Karl, E Webster, GP Chrousos |
Molecular Medicine | 1996 |
New Horizons in Allergy Immunotherapy
A Sehon, KT HayGlass, D Kraft |
1996 | |
Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans
CM Bamberger, AM Bamberger, M Castro, GP Chrousos |
Journal of Clinical Investigation | 1995 |
The Glucocorticoid Receptor and RU 486 in Man
CM Bamberger, GP Chrousos |
Annals of the New York Academy of Sciences | 1995 |
Down regulation of glucocorticoid receptor expressions in young patients with steroid-resistant nephrotic syndrome
Y Tunoda, T Yoshioka, N Iwamoto, H Shiraga, M Hattori, K Nomura, S Shimizu, R Kubota, Y Fukuda, H Kawaguchi, K Ito |
Nihon Shoni Jinzobyo Gakkai Zasshi | 1995 |
Anderson and Coyle reply
GP Anderson, AJ Coyle |
Trends in Pharmacological Sciences | 1995 |
Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma
DY Leung, RJ Martin, SJ Szefler, ER Sher, S Ying, AB Kay, Q Hamid |
Journal of Experimental Medicine | 1995 |
Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma
IM Adcock, SJ Lane, CR Brown, TH Lee, PJ Barnes |
Journal of Experimental Medicine | 1995 |
Steroid-resistant asthma
DY Leung |
The Western journal of medicine | 1995 |
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
JS Flier, LH Underhill, GP Chrousos |
New England Journal of Medicine | 1995 |
Cushing's Syndrome
DN Orth |
New England Journal of Medicine | 1995 |
The genetic basis of glucocorticoid resistance
M Brönnegård, J Carlstedt-Duke |
Trends in Endocrinology & Metabolism | 1995 |
Management of Steroid-Resistant Asthma
LP Landwehr, JD Spahn, SJ Szefler, DY Leung |
Clinical immunotherapeutics | 1995 |
Corticosteroids in the Treatment of Asthma: Practical Recommendations
KA McGill, B Joseph, WW Busse |
Clinical immunotherapeutics | 1995 |
Glucocorticoid and mineralocorticoid resistance
PA Komesaroff, MC Zennaro |
Journal of Endocrinological Investigation | 1995 |
Glucocorticoid Resistance in Asthma
PJ Barnes, AP Greening, GK Crompton |
American journal of respiratory and critical care medicine | 1995 |
Effect of Saiboku-to (chai-pu-tang), a traditional herbal medicine, on the expression of tumor necrosis factor during late asthmatic response in guinea-pigs
Y Tanno, D Zhu, K Maeda, H Iijima, I Ohno, LH Pan, H Ohtani, H Nagura, K Shirato |
International Journal of Immunopharmacology | 1995 |
Glucocorticosteroid Resistance in Humans. Elucidation of the Molecular Mechanisms and Implications for Pathophysiology
CA Stratakis, M Karl, HM Schulte, GP Chrousos |
Annals of the New York Academy of Sciences | 1994 |
Coexistence of glucocorticoid receptor and pharmacokinetic abnormalities: Factors that contribute to a poor response to treatment with glucocorticoids in children with asthma
AK Kamada, JD Spahn, W Surs, E Brown, DY Leung, SJ Szefler |
The Journal of Pediatrics | 1994 |
Mechanisms of the Human Allergic Response: Clinical Implications
DY Leung |
Pediatric Clinics of North America | 1994 |
Pharmacogenetics
BM Watson |
Anaesthesia | 1969 |