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Citations to this article

Corticotropin-releasing hormone, proopiomelanocortin, and glucocorticoid receptor gene expression in adrenocorticotropin-producing tumors in vitro.
T Suda, … , M Yamada, H Demura
T Suda, … , M Yamada, H Demura
Published December 1, 1993
Citation Information: J Clin Invest. 1993;92(6):2790-2795. https://doi.org/10.1172/JCI116898.
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Research Article

Corticotropin-releasing hormone, proopiomelanocortin, and glucocorticoid receptor gene expression in adrenocorticotropin-producing tumors in vitro.

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Abstract

To differentiate between ectopic ACTH syndrome and Cushing's disease, gene expression of corticotropin-releasing hormone (CRH), proopiomelanocortin (POMC), and glucocorticoid receptor was examined in 10 pituitary adenomas (Cushing's disease) and in 10 ectopic ACTH-producing tumors. CRH increased plasma ACTH levels in all patients with Cushing's disease and in five patients with ectopic ACTH syndrome whose tumors contained CRH and CRH mRNA. In five CRH nonresponders, CRH was not detected in tumors that contained no CRH mRNA or that contained only long-size CRH mRNA. Dexamethasone (Dex) decreased plasma ACTH levels in all patients with Cushing's disease and in three patients with ectopic ACTH-producing bronchial carcinoid. These tumors contained glucocorticoid receptor mRNA. CRH increased and Dex decreased ACTH release and POMC mRNA levels in pituitary adenoma and bronchial carcinoid cells. PMA increased POMC mRNA levels only in carcinoid cells. These results reveal characteristics of ectopic ACTH-producing tumors: long-size CRH mRNA and PMA-induced POMC gene expression. In addition, there are two ectopic ACTH syndrome subtypes: tumors containing ACTH with CRH (CRH responder) and tumors without CRH. Dex decreases ACTH release and POMC mRNA levels in some bronchial carcinoids. Therefore, CRH and Dex tests have limited usefulness in differentiating between Cushing's disease and ectopic ACTH syndrome.

Authors

T Suda, F Tozawa, I Dobashi, N Horiba, N Ohmori, M Yamakado, M Yamada, H Demura

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Total citations by year

Year: 2025 2024 2021 2020 2019 2018 2017 2016 2014 2013 2012 2011 2010 2009 2007 2004 2003 2001 2000 1998 1996 1995 Total
Citations: 1 1 1 2 1 1 2 3 1 1 1 1 1 2 1 2 2 2 2 1 1 1 31
Citation information
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Citations to this article (31)

Title and authors Publication Year
Cushing syndrome.
Nieman LK, Castinetti F, Newell-Price J, Valassi E, Drouin J, Takahashi Y, Lacroix A
Nature reviews. Disease primers 2025
Longitudinal Evaluation of Reproductive Endocrine Function in Men With ACTH-Dependent Cushing Syndrome
Shekhar S, McGlotten RN, Cutler GB Jr, Crowley MJ, Pieper CF, Nieman LK, Hall JE
The Journal of Clinical Endocrinology and Metabolism 2024
Molecular Derangements and the Diagnosis of ACTH-Dependent Cushing’s Syndrome
Nieman LK
Endocrine reviews 2021
The Mechanisms Underlying Autonomous Adrenocorticotropic Hormone Secretion in Cushing’s Disease
H Fukuoka, H Shichi, M Yamamoto, Y Takahashi
International journal of molecular sciences 2020
High accuracy of bilateral and simultaneous petrosal sinus sampling with desmopressin for the differential diagnosis of pediatric ACTH-dependent Cushing’s syndrome
LB Cavalcante, TC Freitas, NR Musolino, VA Cescato, GO Silva, MC Fragoso, P Puglia, MD Bronstein, MC Machado
Pituitary 2020
Ectopic cushing’s syndrome due to corticotropin releasing hormone
M Nakhjavani, A Amirbaigloo, S Rabizadeh, F Rotondo, K Kovacs, AA Ghazi
Pituitary 2019
Two types of ectopic Cushing syndrome or a continuum? Review
MA Castro, MM Azpiroz
Pituitary 2018
An activating mutation in the CRHR1 gene is rarely associated with pituitary-dependent hyperadrenocorticism in poodles
V De-Marco, LR Carvalho, MF Guzzo, PS Oliveira, LG Gomes, BB Mendonca
Clinics 2017
Adrenal Disorders
AC Levine
Adrenal Disorders 2017
Proopiomelanocortin, glucocorticoid, and CRH receptor expression in human ACTH-secreting pituitary adenomas
MF Cassarino, A Sesta, L Pagliardini, M Losa, G Lasio, F Cavagnini, FP Giraldi
Endocrine 2016
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee
Endocrinology: Adult and Pediatric 2016
Endocrinology
C Napier, SH Pearce
Endocrinology 2016
Neuropeptide Y Attenuates Stress-Induced Bone Loss Through Suppression of Noradrenaline Circuits: NPY PROTECTS FROM STRESS-INDUCED BONE LOSS
PA Baldock, S Lin, L Zhang, T Karl, Y Shi, F Driessler, A Zengin, B Hörmer, NJ Lee, IP Wong, EJ Lin, RF Enriquez, B Stehrer, MJ During, E Yulyaningsih, S Zolotukhin, ST Ruohonen, E Savontaus, A Sainsbury, H Herzog
Journal of Bone and Mineral Research 2014
Evaluation of the diagnostic criteria for Cushing^|^rsquo;s disease in Japan [Review]
K Kageyama, Y Oki, S Sakihara, T Nigawara, K Terui, T Suda
Endocrine Journal 2013
Locomotor sensitization to EtOH: contribution of β-Endorphin
S Dempsey, JE Grisel
Frontiers in molecular neuroscience 2012
THE GLUCOCORTICOID RECEPTOR AND ITS EXPRESSION IN THE ANTERIOR PITUITARY AND THE ADRENAL CORTEX: A SOURCE OF VARIATION IN HYPOTHALAMIC-PITUITARY-ADRENAL AXIS FUNCTION; IMPLICATIONS FOR PITUITARY AND ADRENAL TUMORS
G Briassoulis, S Damjanovic, P Xekouki, H Lefebvre, CA Stratakis
Endocrine Practice 2011
The corticotropin releasing factor system in cancer: expression and pathophysiological implications
A Kaprara, K Pazaitou-Panayiotou, A Kortsaris, E Chatzaki
Cellular and Molecular Life Sciences 2010
Yen & Jaffe's Reproductive Endocrinology
RA Lobo
Yen & Jaffe's Reproductive Endocrinology 2009
Evaluation of Diagnostic Tests for ACTH-Dependent Cushing’s Syndrome
T SUDA, K KAGEYAMA, T NIGAWARA, S SAKIHARA
Endocrine Journal 2009
Evaluation of proopiomelanocortin mRNA in the peripheral blood from patients with Cushing’s syndrome of different origin
S Bondioni, G Mantovani, N Polentarutti, B Ambrosi, P Loli, E Peverelli, AG Lania, P Beck-Peccoz, A Spada
Journal of Endocrinological Investigation 2007
The Nelson's syndrome... revisited
G Assié, H Bahurel, J Bertherat, M Kujas, P Legmann, X Bertagna
Pituitary 2004
Physiological roles of urocortins, human homologues of fish urotensin I, and their receptors
T Suda, K Kageyama, S Sakihara, T Nigawara
Peptides 2004
Endocrine paraneoplastic syndromes in lung cancer
PJ Mazzone, AC Arroliga
Current Opinion in Pulmonary Medicine 2003
The corticotrophin-releasing hormone test is the most reliable noninvasive method to differentiate pituitary from ectopic ACTH secretion in Cushing's syndrome
G Reimondo, P Paccotti, M Minetto, A Termine, G Stura, M Bergui, A Angeli, M Terzolo
Clinical Endocrinology 2003
The Role of Hormones, Growth Factors and Their Receptors in Pituitary Tumorigenesis
S Ezzat
Brain Pathology 2001
Ectopic ACTH syndrome: Molecular bases and clinical heterogeneity
M Terzolo, G Reimondo, A Alì, S Bovio, F Daffara, P Paccotti, A Angeli
Annals of Oncology 2001
Corticotropin Releasing Hormone and Proopiomelanocortin Involvement in the Cutaneous Response to Stress
A Slominski, J Wortsman, T Luger, R Paus, S Solomon
Physiological reviews 2000
Effects of dexamethasone on rhinovirus infection in cultured human tracheal epithelial cells
T Suzuki, M Yamaya, K Sekizawa, N Yamada, K Nakayama, S Ishizuka, M Kamanaka, T Morimoto, Y Numazaki, H Sasaki
American journal of physiology. Lung cellular and molecular physiology 2000
The Cytogenesis and Pathogenesis of Pituitary Adenomas*
SL Asa, S Ezzat
Endocrine reviews 1998
The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome
Y Keyzer, F Lenne, C Auzan, S Jégou, P René, H Vaudry, JM Kuhn, JP Luton, E Clauser, X Bertagna
Journal of Clinical Investigation 1996
Cushing's Syndrome
DN Orth
New England Journal of Medicine 1995

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