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Citations to this article

Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease. Studies in nondiabetic and diabetic subjects.
R Meyer-Schwickerath, … , R Röllmann, H Schatz
R Meyer-Schwickerath, … , R Röllmann, H Schatz
Published December 1, 1993
Citation Information: J Clin Invest. 1993;92(6):2620-2625. https://doi.org/10.1172/JCI116877.
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Research Article Article has an altmetric score of 3

Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease. Studies in nondiabetic and diabetic subjects.

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Abstract

Retinal capillary nonperfusion results in neovascularization of the eye, which is restricted to the retina in less severe cases and progresses to the anterior chamber and the iris angle in the most advanced case, called rubeosis. This angioneogenesis may be induced by the release of retinal growth factors into the vitreous. This study compared levels of the IGF-I and IGF-II, and of the IGF binding protein-2 (IGFBP-2) and IGFBP-3 in vitreous from three groups with different degrees of retinal ischemia, as judged by the extent of neovascularization: a control group without new vessel formation, retinal neovascularization in patients with proliferative diabetic retinopathy, and massive ischemia of various causes resulting in rubeosis. IGF-I and IGFBP-3 were increased 10- and 13-fold in rubeosis (P << 0.01) compared with no ischemia (n = 10), while IGF-II and IGFBP-2 were elevated 2.7- and 4.3-fold (P < 0.01). Within the rubeosis group similar changes were observed independently of the cause of ischemia, which was central vein occlusion, ischemic ophthalmopathy, or intraocular tumor in seven cases and diabetic retinopathy in three samples from two patients. Vitreous from patients with proliferative diabetic retinopathy but without rubeosis (n = 16) contained 2.5- and 2.2-fold elevated levels of IGF-I and of IGFBP-2 (P < 0.05), while IGF-II and IGFBP-3 were increased 1.4- and 1.6-fold, which was not significant. We conclude that: (a) ischemia appears to be a strong stimulus for the local production of IGF-I and -II and of IGFBP-2 and -3 in the eye. (b) Changes in IGF-I and IGFBP-2 in proliferative diabetic retinopathy may be secondary to local ischemia rather than being specific for diabetic retinopathy. (c) IGF-I and IGFBP-3 may play a role in mediating angioneogenesis in the eye.

Authors

R Meyer-Schwickerath, A Pfeiffer, W F Blum, H Freyberger, M Klein, C Lösche, R Röllmann, H Schatz

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1990 1964 Total
Citations: 3 2 3 3 2 1 5 1 2 2 2 9 3 7 3 3 5 11 3 4 7 3 4 12 5 4 2 11 12 2 4 1 1 142
Citation information
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Citations to this article in year 2008 (5)

Title and authors Publication Year
Insulin, insulin analogues and diabetic retinopathy
E Chantelau, R Kimmerle, R Meyer-Schwickerath
Archives Of Physiology And Biochemistry 2008
Results of Intravitreal Bevacizumab for Macular Edema with Retinal Vein Occlusion and Diabetic Macular Edema
JY Kim, EY Kweon, DW Lee, NC Cho
Journal of the Korean Ophthalmological Society 2008
Glaucome néovasculaire
S Auriol, J Douat, L Mahieu, V Pagot-Mathis, A Mathis
EMC - Ophtalmologie 2008
Retinal and Choroidal Angiogenesis
JS Penn
2008
Age-Related Changes of the Human Eye
CA Cavallotti, L Cerulli
2008

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