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Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta.

G Wolf, … , R A Stahl, F N Ziyadeh

G Wolf, … , R A Stahl, F N Ziyadeh

Published September 1, 1993
Citation Information: J Clin Invest. 1993;92(3):1366-1372. https://doi.org/10.1172/JCI116710.

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Role of Reactive Oxygen Species in Angiotensin II-Mediated Renal Growth, Differentiation, and Apoptosis G Wolf	Antioxidants & Redox Signaling	2005
Angiotensin II receptor blocker inhibits p27Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruli ZG Xu, TH Yoo, DR Ryu, HC Park, SK Ha, DS Han, SG Adler, R Natarajan, SW Kang	Kidney International	2005
Levels of transforming growth factor beta 1 in south Indian type 2 diabetic subjects V Viswanathan, C Snehalatha, MB Nair, R Kumutha, A Ramachandran	Diabetes/Metabolism Research and Reviews	2005
Oral Adsorbent Prevents Reduction of Anionic Sites of the Glomerular Basement Membrane in Diabetic Nephropathy K Okada, K Matsumoto, S Takahashi	Nephron Experimental Nephrology	2005
Angiotensin II stimulates alpha3(IV) collagen production in mouse podocytes via TGF-beta and VEGF signalling: implications for diabetic glomerulopathy S Chen, JS Lee, MC la Cruz, A Wang, A Izquierdo-Lahuerta, NK Gandhi, FR Danesh, G Wolf, FN Ziyadeh	Nephrology Dialysis Transplantation	2005
Angiotensin II Mediates High Glucose-Induced TGF-β1 and Fibronectin Upregulation in HPMC through Reactive Oxygen Species H Noh, H Ha, MR Yu, YO Kim, JH Kim, HB Lee	Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis	2005
Translational regulation of vascular endothelial growth factor expression in renal epithelial cells by angiotensin II D Feliers, S Duraisamy, JL Barnes, G Ghosh-Choudhury, BS Kasinath	American journal of physiology. Renal physiology	2004
Diabetic nephropathy: Linking histology, cell biology, and genetics S Adler	Kidney International	2004
Albumin up-regulates the type II transforming growth factor-beta receptor in cultured proximal tubular cells1 G Wolf, R Schroeder, FN Ziyadeh, RA Stahl	Kidney International	2004
Ramipril treatment suppresses islet fibrosis in Otsuka Long–Evans Tokushima fatty rats SH Ko, HS Kwon, SR Kim, SD Moon, YB Ahn, KH Song, HS Son, BY Cha, KW Lee, HY Son, SK Kang, CG Park, IK Lee, KH Yoon	Biochemical and Biophysical Research Communications	2004
AT1 and AT2 receptor in the kidney: role in health and disease HM Siragy	Seminars in Nephrology	2004
Effect of Angiotensin II on Glomerular Structure in Streptozotocin-Induced Diabetic Rats SB Nicholas, M Mauer, JM Basgen, E Aguiniga, Y Chon	American Journal of Nephrology	2004
Influence of Cytokine Gene Polymorphisms on Focal Segmental Glomerulosclerosis C Bantis, PJ Heering, Y Luther, S Aker, N Kuhr, B Grabensee, K Ivens	American Journal of Nephrology	2004
Effect of aldosterone on renal transforming growth factor- I Juknevicius	AJP Renal Physiology	2004
Effect of sirolimus on renal ischaemia/reperfusion injury in normotensive and hypertensive rats O Viklick, R Bohmov, N Ouyang, E Honsov, A Lodererov, V Mandys, tefan Vtko, J Lutz, UW Heemann	Transplant International	2004
A-20C angiotensinogen gene polymorphism and proteinuria in childhood IgA nephropathy N Yoshikawa, K Nakanishi, M Sako, N Yata, N Aoyagi, K Nozu, R Tanaka, K Iijima	Pediatric Nephrology	2004
Angiotensin II-induced hypertrophy of proximal tubular cells requires p27Kip1 G Wolf, K Jablonski, R Schroeder, R Reinking, SJ Shankland, RA Stahl	Kidney International	2003
Reversibility of established diabetic glomerulopathy by anti-TGF-β antibodies in db/db mice S Chen, MC la Cruz, B Jim, SW Hong, M Isono, FN Ziyadeh	Biochemical and Biophysical Research Communications	2003
Outcome studies in diabetic nephropathy A Mohanram, RD Toto	Seminars in Nephrology	2003
Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells M Gekle, P Knaus, R Nielsen, S Mildenberger, R Freudinger, V Wohlfarth, C Sauvant, EI Christensen	The Journal of Physiology	2003
Role of protein kinase C-angiotensin II pathway for extracellular matrix production in cultured human mesangial cells exposed to high glucose levels K Ikehara, H Tada, K Kuboki, T Inokuchi	Diabetes Research and Clinical Practice	2003
Hypertension in Diabetes P Weston, K Leong	Hypertension in Diabetes	2003
Effect of valsartan on urinary protein excretion and renal function in patients with chronic renal allograft nephropathy N Muirhead, A House, DJ Hollomby, AM Jevnikar	Transplantation Proceedings	2003
Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells M Gekle	The Journal of Physiology	2003
High Glucose Stimulates Angiotensinogen Gene Expression and Cell Hypertrophy via Activation of the Hexosamine Biosynthesis Pathway in Rat Kidney Proximal Tubular Cells TJ Hsieh, P Fustier, SL Zhang, JG Filep, SS Tang, JR Ingelfinger, IG Fantus, P Hamet, JS Chan	Endocrinology	2003
Add-On Anti–TGF-β Antibody to ACE Inhibitor Arrests Progressive Diabetic Nephropathy in the Rat A Benigni, C Zoja, D Corna, C Zatelli, S Conti, M Campana, E Gagliardini, D Rottoli, C Zanchi, M Abbate, S Ledbetter, G Remuzzi	Journal of the American Society of Nephrology : JASN	2003
Proximal tubular cells promote fibrogenesis by TGF-beta1-mediated induction of peritubular myofibroblasts M Abbate, C Zoja, D Rottoli, D Corna, S Tomasoni, G Remuzzi	Kidney International	2002
Angiotensin II infusion ameliorates the early phase of a mesangioproliferative glomerulonephritis1 UO Wenzel, F Thaiss, U Helmchen, RA Stahl, G Wolf	Kidney International	2002
Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension1 HF Cheng, CJ Wang, GW Moeckel, MZ Zhang, JA Mckanna, RC Harris	Kidney International	2002
Angiotensin II type 1 receptor blockade ameliorates tubulointerstitial injury induced by chronic potassium deficiency SI Suga, M Mazzali, PE Ray, DH Kang, RJ Johnson	Kidney International	2002
Angiotensin II and IGF-I May Interact to Regulate Tubulointerstitial Cell Kinetics and Phenotypic Changes in Hypertensive Rats S KOBAYASHI, H MORIYA, I NAKABAYASHI, J NISHIYAMA, T FUKUDA	Hypertension Research	2002
Interstitial Fibroblast-Like Cells Express Renin-Angiotensin System Components in a Fibrosing Murine Kidney H Okada, T Inoue, Y Kanno, T Kobayashi, Y Watanabe, JB Kopp, RM Carey, H Suzuki	The American Journal of Pathology	2002
Angiotensin II and progressive renal insufficiency J Gaedeke, NA Noble, WA Border	Current Hypertension Reports	2002
THE ACE INHIBITOR, QUINAPRIL, AMELIORATES PERITONEAL FIBROSIS IN AN ENCAPSULATING PERITONEAL SCLEROSIS MODEL IN MICE T Sawada, Y Ishii, T Tojimbara, I Nakajima, S Fuchinoue, S Teraoka	Pharmacological Research	2002
Glycogenosis type I and diabetes mellitus: a common mechanism for renal dysfunction? HR Mundy, PJ Lee	Medical Hypotheses	2002
Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-β levels R Agarwal, S Siva, SR Dunn, K Sharma	American Journal of Kidney Diseases	2002
Plasminogen activator inhibitor-1 and the kidney AA Eddy	American journal of physiology. Renal physiology	2002
TGF-β1 is an Autocrine Mediator of Renal Tubular Epithelial Cell Growth and Collagen IV Production JP Grande, GM Warner, HJ Walker, AN Yusufi, J Cheng, CE Gray, JB Kopp, KA Nath	Experimental biology and medicine (Maywood, N.J.)	2002
AT1 Angiotensin II receptor mediates intracellular calcium mobilization in normal and cancerous breast cells in primary culture S Greco, MG Elia, A Muscella, C Storelli, S Marsigliante	Cell Calcium	2002
High Glucose Stimulates Angiotensinogen Gene Expression via Reactive Oxygen Species Generation in Rat Kidney Proximal Tubular Cells TJ Hsieh, SL Zhang, JG Filep, SS Tang, JR Ingelfinger, JS Chan	Endocrinology	2002
Insulin Inhibits Dexamethasone Effect on Angiotensinogen Gene Expression and Induction of Hypertrophy in Rat Kidney Proximal Tubular Cells in High Glucose SL Zhang, X Chen, CC Wei, JG Filep, SS Tang, JR Ingelfinger, JS Chan	Endocrinology	2002
Essential Role(s) of the Intrarenal Renin-Angiotensin System in Transforming Growth Factor–β1 Gene Expression and Induction of Hypertrophy of Rat Kidney Proximal Tubular Cells in High Glucose SL Zhang, C To, X Chen, JG Filep, SS Tang, JR Ingelfinger, JS Chan	Journal of the American Society of Nephrology : JASN	2002
The Endocrine System in Diabetes Mellitus H Alrefai, H Allababidi, S Levy, J Levy	Endocrine	2002
Angiotensin and calcium signaling in the pituitary and hypothalamus Cecilia Suárez, Isabel García Tornadú, Carolina Cristina, Jorge Vela, Arturo González Iglesias, Carlos Libertun, Graciela Díaz-Torga, Damasia Becu-Villalobos	Cellular and Molecular Neurobiology	2002
Role of immunocompetent cells in nonimmune renal diseases B Rodriguez-Iturbe, H Pons, J Herrera-Acosta, RJ Johnson	Kidney International	2001
Pathogenesis of diabetic nephropathy: focus on transforming growth factor-β and connective tissue growth factor OV Sakharova, MW Taal, BM Brenner	Current Opinion in Nephrology and Hypertension	2001
Urinary cytokines: clinically useful markers of chronic renal disease progression? W Wong, AK Singh	Current Opinion in Nephrology and Hypertension	2001
Cell proliferation and protein synthesis as initial factors in determination of axial polarity RA Flickinger	Development, Growth and Differentiation	2001
RENALARTERYSTENOSIS: A Common, Treatable Cause of Renal Failure? SC Textor, CS Wilcox	Annual Review of Medicine	2001
Effect of potassium depletion on proximal tubule AT1 receptor localization in normal and remnant rat kidney JN Fryer, KD Burns, M Ghorbani, DZ Levine	Kidney International	2001
CAPTOPRIL RESTORES TRANSFORMING GROWTH FACTOR-β TYPE II RECEPTOR AND SENSITIVITY TO TRANSFORMING GROWTH FACTOR-β IN MURINE RENAL CELL CANCER CELLS A Miyajima, T Asano, M Hayakawa	The Journal of Urology	2001
Pathophysiology of ischemic nephropathy L Lerman, SC Textor	Urologic Clinics of North America	2001
Antioxidant treatment induces transcription and expression of transforming growth factor beta in cultured renal proximal tubular cells G Wolf, T Hannken, R Schroeder, G Zahner, F N Ziyadeh, R A Stahl	FEBS Letters	2001
Maternal Serum Transforming Growth Factor Beta-2 in Preeclampsia and Eclampsia, a Potential Biomarker for the Assessment of Disease Severity and Fetal Outcome M Shaarawy, ME Meleigy, K Rasheed	Journal of the Society for Gynecologic Investigation	2001
Quantification of TGF-β1 mRNA along rat nephron in obstructive nephropathy K Fukuda, K Yoshitomi, T Yanagida, M Tokumoto, H Hirakata	American journal of physiology. Renal physiology	2001
Role of angiotensin II in diabetic nephropathy DJ Leehey, AK Singh, N Alavi, R Singh	Kidney International	2000
Transforming growth factor-beta1 increases albumin permeability of isolated rat glomeruli via hydroxyl radicals R Sharma, A Khanna, M Sharma, VJ Savin	Kidney International	2000
Transforming growth factor-?? and renal graft fibrosis OG Pankewycz	Current Opinion in Organ Transplantation	2000
INTERACTION OF NITRIC OXIDE AND TRANSFORMING GROWTH FACTOR-??1 INDUCED BY ANGIOTENSIN II AND MECHANICAL STRETCH IN RAT RENAL TUBULAR EPITHELIAL CELLS A Miyajima, J Chen, I Kirman, DP Poppas, ED Vaughan, D Felsen	The Journal of Urology	2000
Southwestern Internal Medicine Conference MA Vazquez	The American Journal of the Medical Sciences	2000
Activation of transforming growth factor-β1 in diabetic kidney disease B Hellmich, M Schellner, H Schatz, A Pfeiffer	Metabolism	2000
INTERACTION OF NITRIC OXIDE AND TRANSFORMING GROWTH FACTOR-β1 INDUCED BY ANGIOTENSIN II AND MECHANICAL STRETCH IN RAT RENAL TUBULAR EPITHELIAL CELLS A Miyajima, J Chen, I Kirman, DP Poppas, ED Vaughan, D Felsen	The Journal of Urology	2000
Increased urinary transforming growth factor- beta1 excretion in children with posterior urethral valves KM Dell, BB Hoffman, MB Leonard, FN Ziyadeh, SL Schulman	Urology	2000
ACE inhibitors attenuate expression of renal transforming growth factor-β1 in humans GT Shin, SJ Kim, KA Ma, HS Kim, D Kim	American Journal of Kidney Diseases	2000
Transforming growth factor β (TGF-β) en la enfermedad de Gaucher. Resultados preliminares en un grupo de enfermos y familiares portadores y no portadores JI Calvo, MA Cabeza, PI Gil, PG Castellano, F Civeira, SL García, M Pocoví	Medicina Clínica	2000
Angiotensin II and its receptors in the diabetic kidney KD Burns	American Journal of Kidney Diseases	2000
Angiotensin II Is Mitogenic for Human Lung Fibroblasts via Activation of the Type 1 Receptor RP Marshall, RO McANULTY, GJ Laurent	American journal of respiratory and critical care medicine	2000
ACE gene polymorphism and renal responsiveness to ACE inhibitors in IgA nephropathy patients S Y Han, Y J Kwon, S K Jo, J H Shin, D R Cha, W Y Cho, H J Pyo, H K Kim	The Korean Journal of Internal Medicine	2000
Chronic Rejection of Renal Transplants: New Clinical Insights NM Kaplan, BF Palmer, MA Vazquez	The American Journal of the Medical Sciences	2000
Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis SJ Shankland, G Wolf	American journal of physiology. Renal physiology	2000
Influence of nephron mass in development of chronic renal failure after prolonged warm renal ischemia JM Cruzado, J Torras, M Riera, I Herrero, M Hueso, L Espinosa, E Condom, N Lloberas, J Bover, J Alsina, JM Grinyó	American journal of physiology. Renal physiology	2000
High Levels of Glucose Stimulate Angiotensinogen Gene Expression Via the P38 Mitogen-Activated Protein Kinase Pathway in Rat Kidney Proximal Tubular Cells 1 SL Zhang, SS Tang, X Chen, JG Filep, JR Ingelfinger, JS Chan	Endocrinology	2000
The Kidney and Hypertension in Diabetes Mellitus CE Mogensen		2000
Modification of the Epidermal Growth Factor Response by Ammonia in Renal Cell Hypertrophy HA Franch	Journal of the American Society of Nephrology : JASN	2000
Glycosaminoglycans: Use in Treatment of Diabetic Nephropathy G Gambaro, FJ Woude	Journal of the American Society of Nephrology : JASN	2000
Reactive Oxygen Species Stimulate p44/42 Mitogen-Activated Protein Kinase and Induce p27 Kip1: Role in Angiotensin II-Mediated Hypertrophy of Proximal Tubular Cells T Hannken, R Schroeder, G Zahner, RA Stahl, G Wolf	Journal of the American Society of Nephrology : JASN	2000
Pathological Expression of Renin and Angiotensin II in the Renal Tubule after Subtotal Nephrectomy RE Gilbert, LL Wu, DJ Kelly, A Cox, JL Wilkinson-Berka, CI Johnston, ME Cooper	The American Journal of Pathology	1999
Angiotensin IV stimulates plasminogen activator inhibitor-1 expression in proximal tubular epithelial cells L Gesualdo, E Ranieri, R Monno, MR Rossiello, M Colucci, N Semeraro, G Grandaliano, FP Schena, M Ursi, G Cerullo	Kidney International	1999
Molecular mechanisms of diabetic renal hypertrophy G Wolf, FN Ziyadeh	Kidney International	1999
Obstructive uropathy in the mouse: Role of osteopontin in interstitial fibrosis and apoptosis V Ophascharoensuk, CM Giachelli, K Gordon, J Hughes, R Pichler, P Brown, L Liaw, R Schmidt, SJ Shankland, CE Alpers, WG Couser, RJ Johnson	Kidney International	1999
TGF-beta-activating kinase-1 inhibits cell cycle and expression of cyclin D1 and A in LLC-PK1 cells Y Terada, O Nakashima, S Inoshita, M Kuwahara, S Sasaki, F Marumo	Kidney International	1999
Losartan-sensitive renal damage caused by chronic NOS inhibition does not involve increased renal angiotensin II concentrations AM Verhagen, B Braam, P Boer, HJ Gröne, HA Koomans, JA Joles	Kidney International	1999
Cardiac Hypertrophy: Signal Transduction, Transcriptional Adaptation, and Altered Growth Control M Wagner, E Mascareno, M Siddiqui	Annals of the New York Academy of Sciences	1999
Monocyte chemoattractant protein-1 mediates collagen deposition in experimental glomerulonephritis by transforming growth factor-beta A Schneider, U Panzer, G Zahner, U Wenzel, G Wolf, F Thaiss, U Helmchen, RA Stahl	Kidney International	1999
Captopril-induced reduction of serum levels of transforming growth Factor-β1 correlates with long-term renoprotection in insulin-dependent diabetic patients☆☆☆ K Sharma, BO Eltayeb, TA McGowan, SR Dunn, B Alzahabi, R Rohde, FN Ziyadeh, EJ Lewis	American Journal of Kidney Diseases	1999
TGF-β and fibrosis MH Branton, JB Kopp	Microbes and Infection	1999
TGF-β: from latent to active N Khalil	Microbes and Infection	1999
A cell cycle-dependent mechanism of renal tubule epithelial cell hypertrophy P Preisig	Kidney International	1999
Molecular mechanisms of renal hypertrophy: Role of p27Kip1 G Wolf	Kidney International	1999
Renoprotective effect of ACE inhibitors: Dissecting the molecular clues and expanding the blood pressure goal G Remuzzi	American Journal of Kidney Diseases	1999
Remission of nephrotic syndrome in type 1 diabetes: Long-term follow-up of patients in the Captopril Study WA Wilmer, LA Hebert, EJ Lewis, RD Rohde, F Whittier, D Cattran, AS Levey, JB Lewis, S Spitalewitz, S Blumenthal, RP Bain	American Journal of Kidney Diseases	1999
Angiotensin II induces alpha3(IV) collagen expression in cultured murine proximal tubular cells G Wolf, R Kalluri, F N Ziyadeh, E G Neilson, R A Stahl	Proceedings of The Association of American Physicians	1999
A Signaling Pathway for Stimulation of Na+ Uptake Induced by Angiotensin II in Primary Cultured Rabbit Renal Proximal Tubule Cells HJ HAN, HJ KOH, SH Park	Journal of Veterinary Medical Science	1999
Insulin Inhibits Angiotensinogen Gene Expression via the Mitogen-Activated Protein Kinase Pathway in Rat Kidney Proximal Tubular Cells1 SL Zhang, X Chen, JG Filep, SS Tang, JR Ingelfinger, JS Chan	Endocrinology	1999
High Glucose Stimulates Proliferation and Collagen Type I Synthesis in Renal Cortical Fibroblasts: Mediation by Autocrine Activation of TGF-β DC Han, M Isono, BB Hoffman, FN Ziyadeh	Journal of the American Society of Nephrology : JASN	1999
Effect of glucose on the expression of the angiotensinogen gene in opossum kidney cells TT Wang, XH Wu, SL Zhang, JS Chan	Kidney International	1998
Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis SE Thomas, TF Andoh, RH Pichler, SJ Shankland, WG Couser, WM Bennett, RJ Johnson	Kidney International	1998
Angiotensin II-mediated expression of p27Kip1 and induction of cellular hypertrophy in renal tubular cells depend on the generation of oxygen radicals1 T Hannken, R Schroeder, RA Stahl, G Wolf	Kidney International	1998
TGF-beta1 dissociates human proximal tubule cell growth and Na+-H+ exchange activity DW Johnson, HJ Saunders, BK Brew, P Poronnik, DI Cook, MJ Field, CA Pollock	Kidney International	1998
Erythropoietin upregulates angiotensin receptors in cultured rat vascular smooth muscle cells JD Barrett, Z Zhang, JH Zhu, DB Lee, HJ Ward, N Jamgotchian, MS Hu, A Fredal, M Giordani, P Eggena	Journal of Hypertension	1998
Upper urinary tract obstruction: experimental and clinical aspects NGUYEN, KOGAN	BJU International	1998
Pathophysiology of Progressive Nephropathies FH Epstein, G Remuzzi, T Bertani	New England Journal of Medicine	1998
Advances in Organ Biology AJ Liedtke	Advances in Organ Biology	1998
TGF-β type II receptor in rat renal vascular development: Localization to juxtaglomerular cells A Liu, BJ Ballermann	Kidney International	1998
Growth Factors and the Kidney in Diabetes Mellitus G Gambaro, B Baggio	Critical Reviews in Clinical Laboratory Sciences	1998
Role of AT 1 angiotensin II receptors in renal ischemic injury J Kontogiannis, KD Burns	American journal of physiology. Renal physiology	1998
Angiotensin II-induced Ca 2+ mobilization and prolactin release in normal and hyperplastic pituitary cells G Díaz-Torga, AG Iglesias, R Achával-Zaia, C Libertun, D Becú-Villalobos	American journal of physiology. Endocrinology and metabolism	1998
Abnormalities of the Extracellular Degradation of Collagen Type I in Essential Hypertension C Laviades, N Varo, J Fernández, G Mayor, MJ Gil, I Monreal, J Díez	Circulation	1998
Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor G Wolf, FN Ziyadeh, F Thaiss, J Tomaszewski, RJ Caron, U Wenzel, G Zahner, U Helmchen, RA Stahl	Journal of Clinical Investigation	1997
LONG-TERM EFFECT OF MANIDIPINE ON RENAL FUNCTION AND STRUCTURE IN UNINEPHRECTOMIZED SPONTANEOUSLY HYPERTENSIVE RATS M Fujimaki, M Nagase, S Uchida	Clinical and Experimental Pharmacology and Physiology	1997
The role of angiotensin II in diabetic nephropathy: Emphasis on nonhemodynamic mechanisms G Wolf, FN Ziyadeh	American Journal of Kidney Diseases	1997
BIOLOGICAL FUNCTIONS OF ANGIOTENSIN AND ITS RECEPTORS T Matsusaka, I Ichikawa	Annual Review of Physiology	1997
Sodium depletion enhances fibrosis and the expression of TGF-β1 and matrix proteins in experimental chronic cyclosporine nephropathy FS Shihab, TF Andoh, AM Tanner, WM Bennett	American Journal of Kidney Diseases	1997
Transforming growth factor β1 and renal injury following subtotal nephrectomy in the rat: Role of the renin-angiotensin system LL Wu, A Cox, CJ Roe, M Dziadek, ME Cooper, RE Gilbert	Kidney International	1997
Inhibitors of arachidonic acid metabolism modulate the insulin-like growth factor-1-induced growth of proximal tubular cells in primary culture M GEKLE, CA POLLOCK	Nephrology	1997
Angiotensin-Converting Enzyme Inhibition Decreases Growth Factor Expression in the Neonatal Rat Kidney KH Yoo, JT Wolstenholme, RL Chevalier	Pediatric Research	1997
Novel Perspectives on Pituitary and Brain Angiotensinogen C Sernia, T Zeng, D Kerr, B Wyse	Frontiers in Neuroendocrinology	1997
Selective antagonism of the AT1 receptor inhibits angiotensin II stimulated DNA and protein synthesis in primary cultures of human proximal tubular cells PK Chatterjee, RP Weerackody, SK Mistry, GM Hawksworth, JS Mclay	Kidney International	1997
Hypothesis: The role of acquired tubulointerstitial disease in the pathogenesis of salt-dependent hypertension RJ Johnson, GF Schreiner	Kidney International	1997
Aberrant Renal Vascular Morphology and Renin Expression in Mutant Mice Lacking Angiotensin-Converting Enzyme KF Hilgers, V Reddi, JH Krege, O Smithies, RA Gomez	Hypertension	1997
Analytical and Quantitative Cardiology S Sideman, R Beyar		1997
Transforming Growth Factor β in Diabetic Nephropathy WA Border, T Yamamoto, NA Noble	Diabetes/Metabolism Reviews	1996
Polymorphisms of the renin-angiotensin system genes in progressive renal diseases H Yoshida, V Kon, I Ichikawa	Kidney International	1996
Captopril and renal survival in patients with human immunodeficiency virus nephropathy PL Kimmel, GJ Mishkin, WO Umana	American Journal of Kidney Diseases	1996
Simultaneous Bindings of uPA and Latent TGF-.BETA. for the Activation of Latent TGF-.BETA. in Homotypic Smooth Muscle Cells H Abe, M Abe, K Tanaka, C Iwasaka, Y Sato	The Tohoku Journal of Experimental Medicine	1996
Arrested Development of the Neonatal Kidney Following Chronic Ureteral Obstruction KH Chung, RL Chevalier	The Journal of Urology	1996
Angiotensin II-stimulated hypertrophy of LLC-PK1 cells depends on the induction of the cyclin-dependent kinase inhibitor p27Kip1 G Wolf, RA Stahl	Kidney International	1996
Hypertrophy of rabbit proximal tubule cells is associated with overexpression of TGF β C Peñaranda, A Garcia-Ocaña, JL Sarasa, P Esbrit	Life Sciences	1996
Enhanced renal sensitivity to angiotensin actions in diabetes mellitus in the rat J Zimpelmann, D Kumar, DZ Levine, G Wehbi, JD Imig, LG Navar, KD Burns	The American journal of physiology	1996
Enhanced renal sensitivity to angiotensin actions in diabetes mellitus in the rat J Zimpelmann, D Kumar, DZ Levine, G Wehbi, JD Imig, LG Navar, KD Burns	The American journal of physiology	1996
Angiotensin II receptor subtypes in the kidney: Distribution and function J ZHUO, D ALCORN, PJ HARRIS, J McCAUSLAND, GP ALDRED, FA MENDELSOHN	Nephrology	1995
ACE inhibition reduces proteinuria, glomerular lesions and extracellular matrix production in a normotensive rat model of immune complex nephritis M Ruiz-Ortega, S González, D Serón, E Condom, C Bustos, R Largo, E González, A Ortiz, J Egido	Kidney International	1995
TGF-β and phorbol esters inhibit mitogenesis utilizing parallel protein kinase C-dependent pathways RH Weiss, AP Yabes, R Sinaee	Kidney International	1995
Localization of transforming growth factor-β and latent transforming growth factor-β binding protein in rat kidney T Ando, S Okuda, K Tamaki, K Yoshitomi, M Fujishima	Kidney International	1995
Angiotensin II-stimulated expression of transforming growth factor beta in renal proximal tubular cells: Attenuation after stable transfection with the c-mas oncogene G Wolf, FN Ziyadeh, G Zahner, RA Stahl	Kidney International	1995
Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria AA Eddy, CM Giachelli, L McCulloch, E Liu	Kidney International	1995
Involvement of pRB family in TGF beta-dependent epithelial cell hypertrophy HA Franch, JW Shay, RJ Alpern, PA Preisig	The Journal of Cell Biology	1995
Comparison of antiproliferative effects of atrial natriuretic peptide and transforming growth factor β on rabbit kidney proximal tubule cells A García-Ocaña, C Peñaranda, P Esbrit	Life Sciences	1995
Hypertension in pregnancy: Changes in activin a maternal serum concentration F Petraglia, L Aguzzoli, A Gallinelli, P Florio, M Zonca, C Benedetto, K Woodruff	Placenta	1995
Sequential activation of MAP kinase cascade by angiotensin II in opossum kidney cells Y Terada, K Tomita, MK Homma, H Nonoguchi, T Yang, T Yamada, Y Yuasa, EG Krebs, F Marumo	Kidney International	1995
Angiotensin II stimulates the autocrine production of transforming growth factor-β1 in adult rat cardiac fibroblasts AA Lee, WH Dillmann, AD McCulloch, FJ Villarreal	Journal of Molecular and Cellular Cardiology	1995
Signaling and growth responses of LLC-PK1/Cl4 cells transfected with the rabbit AT1 ANG II receptor KD Burns, RC Harris	American journal of physiology. Cell physiology	1995
Tubulointerstitial and Cystic Disease of the Kidney SM Dodd		1995
Tissue Renin-Angiotensin Systems AK Mukhopadhyay, MK Raizada		1995
In situ hybridization and immunohistochemistry of renal angiotensinogen in neonatal and adult rat kidneys IA Darby, C Sernia	Cell and Tissue Research	1995
Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta FN Ziyadeh, K Sharma, M Ericksen, G Wolf	Journal of Clinical Investigation	1994
Polyol pathway mediates high glucose-induced collagen synthesis in proximal tubule AJ Bleyer, P Fumo, ER Snipes, S Goldfarb, DA Simmons, FN Ziyadeh	Kidney International	1994
Cellular and ultrastructural location of angiotensinogen in rat and sheep kidney IA Darby, M Congiu, RT Fernley, C Sernia, JP Coghlan	Kidney International	1994
Chronic transplant rejection TH Hostetter	Kidney International	1994
ANGIOTENSIN RECEPTORS IN CARDIOVASCULAR DISEASES L Brown, C Sernia	Clinical and Experimental Pharmacology and Physiology	1994
Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations SL Zhang, JG Filep, TC Hohman, SS Tang, JR Ingelfinger, JS Chan	The American journal of physiology	1993
Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations SL Zhang, JG Filep, TC Hohman, SS Tang, JR Ingelfinger, JS Chan	The American journal of physiology	1993
Regulating factors of renal tubular hypertrophy G Wolf	The Clinical Investigator	1993
Author's reply TT Lao	BJOG: An International Journal of Obstetrics and Gynaecology	1990

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