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Citations to this article

Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model.
C H Warden, … , K L Svenson, A J Lusis
C H Warden, … , K L Svenson, A J Lusis
Published August 1, 1993
Citation Information: J Clin Invest. 1993;92(2):773-779. https://doi.org/10.1172/JCI116649.
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Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model.

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Abstract

We have examined backcross progeny derived from a cross of Mus spretus with C57BL/6J, that range from 1 to 50% carcass lipid (n = 215), and from 22 to 130 mg/dl plasma total cholesterol (n = 238). Statistical analysis revealed that distal mouse chromosome 7 exhibits significant linkage both to plasma total cholesterol (likelihood of the odds [LOD] 5.8) and to carcass lipid (LOD 3.8). A locus on chromosome 6 also shows significant linkage to plasma total cholesterol (LOD 5.6), but no linkage to carcass lipid. Neither chromosomal region contains any previously mapped genes likely to influence lipoprotein metabolism, indicating that novel genetic factors contributing to plasma lipoprotein levels have been identified.

Authors

C H Warden, J S Fisler, M J Pace, K L Svenson, A J Lusis

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Total citations by year

Year: 2018 2017 2015 2013 2011 2010 2009 2007 2006 2005 2004 2003 2001 2000 1999 1997 1996 1995 1994 1993 Total
Citations: 1 1 1 1 1 1 2 1 3 4 7 5 1 1 2 7 6 8 5 1 59
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