We have examined backcross progeny derived from a cross of Mus spretus with C57BL/6J, that range from 1 to 50% carcass lipid (n = 215), and from 22 to 130 mg/dl plasma total cholesterol (n = 238). Statistical analysis revealed that distal mouse chromosome 7 exhibits significant linkage both to plasma total cholesterol (likelihood of the odds [LOD] 5.8) and to carcass lipid (LOD 3.8). A locus on chromosome 6 also shows significant linkage to plasma total cholesterol (LOD 5.6), but no linkage to carcass lipid. Neither chromosomal region contains any previously mapped genes likely to influence lipoprotein metabolism, indicating that novel genetic factors contributing to plasma lipoprotein levels have been identified.
C H Warden, J S Fisler, M J Pace, K L Svenson, A J Lusis
Title and authors | Publication | Year |
---|---|---|
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Chow fed UC Davis strain female Lepr fatty Zucker rats exhibit mild glucose intolerance, hypertriglyceridemia, and increased urine volume, all reduced by a Brown Norway strain chromosome 1 congenic donor region
CH Warden, A Bettaieb, E Min, JS Fisler, FG Haj, JS Stern, CM Stover |
PloS one | 2017 |
Obesity genetics in mouse and human: back and forth, and back again
FT Yazdi, SM Clee, D Meyre |
PeerJ | 2015 |
Emery and Rimoin's Principles and Practice of Medical Genetics
DC Wallace, MT Lott, V Procaccio |
Emery and Rimoin's Principles and Practice of Medical Genetics | 2013 |
The role of genetic research in sport
M Sawczuk, A Maciejewska, P Cięszczyk, J Eider |
Science & Sports | 2011 |
Genetic analysis of abdominal fat distribution in SM/J and A/J mice
M Kobayashi, T Ohno, N Hada, M Fujiyoshi, M Kuga, M Nishimura, A Murai, F Horio |
Journal of lipid research | 2010 |
The Thrsp null mouse (Thrsptm1cnm) and diet-induced obesity
GW Anderson, Q Zhu, J Metkowski, MJ Stack, S Gopinath, CN Mariash |
Molecular and Cellular Endocrinology | 2009 |
Histological, Immunocytochemical, and Morphometrical Analyses of Pancreatic Islets in the BSB Mouse Model of Obesity
BG Slavin, C Zarow, CH Warden, JS Fisler |
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology | 2009 |
Identification of positional candidate genes for body weight and adiposity in subcongenic mice
S Chiu, K Kim, KA Haus, GM Espinal, LV Millon, CH Warden |
Physiological genomics | 2007 |
The Human Obesity Gene Map: The 2005 Update
T Rankinen, A Zuberi, YC Chagnon, SJ Weisnagel, G Argyropoulos, B Walts, L Pérusse, C Bouchard |
Obesity | 2006 |
A meta-analysis of quantitative trait loci associated with body weight and adiposity in mice
S Wuschke, S Dahm, C Schmidt, HG Joost, H Al-Hasani |
International Journal of Obesity | 2006 |
QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains ,
H Wittenburg, MA Lyons, R Li, U Kurtz, X Wang, J Mössner, GA Churchill, MC Carey, B Paigen |
Journal of lipid research | 2006 |
The human obesity gene map: the 2004 update
L Pérusse, T Rankinen, A Zuberi, YC Chagnon, SJ Weisnagel, G Argyropoulos, B Walts, EE Snyder, C Bouchard |
Obesity research | 2005 |
Nutrition and Disease Prevention
K Imaizumi |
Soy in Health and Disease Prevention | 2005 |
Apolipoprotein Gene Polymorphisms as Cause of Cholesterol QTLs in Mice
J SUTO |
Journal of Veterinary Medical Science | 2005 |
Integrating Genetic and Gene Expression Data to Study the Metabolic Syndrome and Diabetes in Mice
TA Drake, EE Schadt, RC Davis, AJ Lusis |
American Journal of Therapeutics | 2005 |
Reciprocal hemizygosity analysis of mouse hepatic lipase reveals influence on obesity
P Farahani, JS Fisler, H Wong, AL Diament, N Yi, CH Warden |
Obesity research | 2004 |
SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
C Duan, M Li, L Rui |
The Journal of biological chemistry | 2004 |
Haplotype analysis in multiple crosses to identify a QTL gene
X Wang, R Korstanje, D Higgins, B Paigen |
Genome research | 2004 |
Characterization of epistasis influencing complex spontaneous obesity in the BSB model
N Yi, A Diament, S Chiu, K Kim, DB Allison, JS Fisler, CH Warden |
Genetics | 2004 |
Obesity in BSB mice is correlated with expression of genes for iron homeostasis and leptin
P Farahani, S Chiu, CL Bowlus, D Boffelli, E Lee, JS Fisler, RM Krauss, CH Warden |
Obesity research | 2004 |
A novel mouse Chromosome 2 congenic strain with obesity phenotypes
AL Diament, P Farahani, S Chiu, J Fisler, CH Warden |
Mammalian Genome | 2004 |
Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice
N Yi, S Chiu, DB Allison, JS Fisler, CH Warden |
Journal of lipid research | 2004 |
Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice.
Colinayo VV, Qiao JH, Wang X, Krass KL, Schadt E, Lusis AJ, Drake TA |
Mammalian genome : official journal of the International Mammalian Genome Society | 2003 |
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini |
International Textbook of Diabetes Mellitus | 2003 |
Quantitative Trait Locus Analysis of Serum Insulin, Triglyceride, Total Cholesterol and Phospholipid Levels in the (SM/J*A/J)F2 Mice
RV ANUNCIADO, M NISHIMURA, M MORI, A ISHIKAWA, S TANAKA, F HORIO, T OHNO, T NAMIKAWA |
Experimental Animals | 2003 |
Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains
DR Reed, X Li, AH McDaniel, K Lu, S Li, MG Tordoff, RA Price, AA Bachmanov |
Mammalian genome : official journal of the International Mammalian Genome Society | 2003 |
Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice
TL Horvath, S Diano, S Miyamoto, S Barry, S Gatti, D Alberati, F Livak, A Lombardi, M Moreno, F Goglia, G Mor, J Hamilton, D Kachinskas, B Horwitz, CH Warden |
International Journal of Obesity | 2003 |
Inflammatory Bowel Disease
KD Taylor, H Yang, JI Rotter |
Molecular Genetics and Metabolism | 2001 |
A novel ATPase on mouse chromosome 7 is a candidate gene for increased body fat
M Dhar, LS Webb, L Smith, L Hauser, D Johnson, DB West |
Physiological genomics | 2000 |
Quantitative trait locus analysis of plasma lipoprotein levels in an autoimmune mouse model : interactions between lipoprotein metabolism, autoimmune disease, and atherogenesis
L Gu, M W Johnson, A J Lusis |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
Quantitative trait loci that regulate plasma lipid concentration in hereditary obese KK and KK-Ay mice
J Suto, S Matsuura, H Yamanaka, K Sekikawa |
Biochimica et Biophysica Acta | 1999 |
Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q
AV Lembertas, L Pérusse, YC Chagnon, JS Fisler, CH Warden, DA Purcell-Huynh, FT Dionne, J Gagnon, A Nadeau, AJ Lusis, C Bouchard |
Journal of Clinical Investigation | 1997 |
Genetic Modifiers ofLeprfaAssociated with Variability in Insulin Production and Susceptibility to NIDDM
WK Chung, M Zheng, M Chua, E Kershaw, L Power-Kehoe, M Tsuji, XS Wu-Peng, J Williams, SC Chua, RL Leibel |
Genomics | 1997 |
The Human Uncoupling Protein-3 Gene: GENOMIC STRUCTURE, CHROMOSOMAL LOCALIZATION, AND GENETIC BASIS FOR SHORT AND LONG FORM TRANSCRIPTS
G Solanes, A Vidal-Puig, D Grujic, JS Flier, BB Lowell |
The Journal of biological chemistry | 1997 |
Progress in Understanding the Genetics of Obesity
GA Bray |
The Journal of nutrition | 1997 |
Mapping of Mouse Obesity Genes: A Generic Approach to a Complex Trait
JS Fisler, CH Warden |
The Journal of nutrition | 1997 |
Interaction of Diet and Genes in Atherogenesis Report of an NHLBI Working Group
A Tall, C Welch, D Applebaum-Bowden, M Wassef |
Arteriosclerosis, thrombosis, and vascular biology | 1997 |
Production and Processing of Healthy Meat, Poultry and Fish Products
AM Pearson, TR Dutson |
1997 | |
LESSONS FROM ANIMAL MODELS OF OBESITY
DA York |
Endocrinology & Metabolism Clinics of North America | 1996 |
GENETICS OF OBESITY IN HUMANS AND ANIMAL MODELS
DB West |
Endocrinology & Metabolism Clinics of North America | 1996 |
A locus on the X Chromosome is linked to body length in mice
AV Lembertas, JS Fisler, CH Warden, PZ Wen, YR Xia, AJ Lusis |
Mammalian Genome | 1996 |
Current Status of the Human Obesity Gene Map
C Bouchard, L Pérusse |
Obesity research | 1996 |
Fischer 344 rats are the same weight but are fatter than rats fed a high fat diet
RA Schemmel, K Kras, N Cotten, K Suzuki, BK Sharma, MJ VandeHaar |
Nutrition Research | 1996 |
A locus on the X Chromosome is linked to body length in mice
AV Lembertas, JS Fisler, CH Warden, , , AJ Lusis |
Mammalian Genome | 1996 |
Identification of four chromosomal loci determining obesity in a multifactorial mouse model
CH Warden, JS Fisler, SM Shoemaker, PZ Wen, KL Svenson, MJ Pace, AJ Lusis |
Journal of Clinical Investigation | 1995 |
Genetic factors in lipoprotein metabolism. Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach
DA Purcell-Huynh, A Weinreb, LW Castellani, M Mehrabian, MH Doolittle, AJ Lusis |
Journal of Clinical Investigation | 1995 |
The genetics of obesity: from genetic epidemiology to molecular markers
C Bouchard |
Molecular Medicine Today | 1995 |
Genetic Variation on Chromosome 1 Associated With Variation in Body Fat Distribution in Men
RA Hegele, JH Brunt, PW Connelly |
Circulation | 1995 |
Mapping of body weight loci on mouse Chromosome X
TA Dragani, ZB Zeng, F Canzian, M Gariboldi, MT Ghilarducci, G Manenti, MA Pierotti |
Mammalian Genome | 1995 |
Cardiovascular Disease 2
LL Gallo |
1995 | |
Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes
EA Kirk, GL Moe, MT Caldwell, JA Lernmark, DL Wilson, RC LeBoeuf |
Journal of lipid research | 1995 |
Anorexia nervosa viewed as an extreme weight condition: genetic implications
J Hebebrand, H Remschmidt |
Human Genetics | 1995 |
Glycogen synthase: a putative locus for diet-induced hyperglycemia
MF Seldin, D Mott, D Bhat, A Petro, CM Kuhn, SF Kingsmore, C Bogardus, E Opara, MN Feinglos, RS Surwit |
Journal of Clinical Investigation | 1994 |
Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model
DB West, J Goudey-Lefevre, B York, GE Truett |
Journal of Clinical Investigation | 1994 |
Atherosclerosis in mice: getting to the heart of a polygenic disorder
EM Rubin, DJ Smith |
Trends in Genetics | 1994 |
Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification
JH Qiao, PZ Xie, MC Fishbein, J Kreuzer, TA Drake, LL Demer, AJ Lusis |
Arteriosclerosis Thrombosis and Vascular Biology | 1994 |
Linkage analysis of the genetic determinants of high density lipoprotein concentrations and composition: evidence for involvement of the apolipoprotein A-II and cholesteryl ester transfer protein loci
X Bu, CH Warden, YR Xia, CD Meester, DL Puppione, S Teruya, B Lokensgard, S Daneshmand, J Brown, RJ Gray, JI Rotter, AJ Lusis |
Human Genetics | 1994 |
BSB: A New Mouse Model of Multigenic Obesity
JS Fisler, CH Warden, MJ Pace, AJ Lusis |
Obesity research | 1993 |