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Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.

R W Burlingame, … , R S Balderas, A N Theofilopoulos

R W Burlingame, … , R S Balderas, A N Theofilopoulos

Published April 1, 1993
Citation Information: J Clin Invest. 1993;91(4):1687-1696. https://doi.org/10.1172/JCI116378.

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Anti-histone and anti-nucleosome rather than anti-dsDNA antibodies associate with IFN-induced biomarkers in Sudanese and Swedish SLE patients Elbagir S, Mohammed NA, Oke V, Larsson A, Nilsson J, Elshafie A, Elagib EM, Nur MA, Gunnarsson I, Svenungsson E, Rönnelid J	Rheumatology (Oxford, England)	2024
Estrogen Receptor Alpha Signaling Is Responsible for the Female Sex Bias in the Loss of Tolerance and Immune Cell Activation Induced by the Lupus Susceptibility Locus Sle1b JH Graham, SD Yoachim, KA Gould	Frontiers in immunology	2020
SLE presenting as demyelinative autoimmune visual loss A Schattner, S Voichanski, L Uliel	BMJ case reports	2018
T-bet+CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus Y Liu, S Zhou, J Qian, Y Wang, X Yu, D Dai, M Dai, L Wu, Z Liao, Z Xue, J Wang, G Hou, J Ma, JB Harley, Y Tang, N Shen	Arthritis Research & Therapy	2017
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Nitration of H2B histone elicits an immune response in experimental animals MA Khan, K Alam, SM Hassan, MM Rizvi	Autoimmunity	2017
Estrogen Receptor Alpha Signaling Promotes Sle1-Induced Loss of Tolerance and Immune Cell Activation and is Responsible for Sex Bias in B6.Sle1 Congenic Mice SD Yoachim, JS Nuxoll, KK Bynoté, KA Gould	Clinical Immunology	2015
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The Spectrum of Anti-Chromatin/Nucleosome Autoantibodies: Independent and Interdependent Biomarkers of Disease S Mehra, MJ Fritzler	Journal of Immunology Research	2014
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Anti-nucleosome antibodies may predict lupus nephritis and severity of disease in systemic lupus erythematosus H Samy, H Hend, M Sameh, F Hajer, BH Mohamed, B Sofiene, H Jamil, B Zouheir, M Hatem	Indian Journal of Rheumatology	2010
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Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice Maria K Haraldsson, Nathanial G dela Paz, Jason G Kuan, Gary S Gilkeson, Argyrios N Theofilopoulos, Dwight H Kono	Journal of immunology (Baltimore, Md. : 1950)	2005
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Animal Models of T Cell-Mediated Skin Diseases T Zollner, H Renz, K Asadullah		2005
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Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus mice Z Liang, C Xie, C Chen, D Kreska, K Hsu, L Li, XJ Zhou, C Mohan	Journal of Clinical Investigation	2004
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Recent advances in understanding the clinical utility and underlying cause of antinucleosome (antichromatin) autoantibodies RW Burlingame	Clinical and Applied Immunology Reviews	2004
Antihistone and anti–double-stranded deoxyribonucleic acid antibodies are associated with renal disease in systemic lupus erythematosus J Cortés-Hernández, J Ordi-Ros, M Labrador, S Buján, E Balada, A Segarra, M Vilardell-Tarrés	The American Journal of Medicine	2004
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The expression of plasma nucleosomes in mice undergoing in vivo apoptosis N Jiang, CF Reich, M Monestier, DS Pisetsky	Clinical Immunology	2003
Concomitant early appearance of anti-ribonucleoprotein and anti-nucleosome antibodies in lupus prone mice D Laderach, S Koutouzov, JF Bach, AM Yamamoto	Journal of Autoimmunity	2003
Anti-chromatin antibodies in systemic lupus erythematosus: a useful marker for lupus nephropathy R Cervera, O Viñas, M Ramos-Casals, J Font, M García-Carrasco, A Sisó, F Ramírez, Y Machuca, J Vives, M Ingelmo, RW Burlingame	Annals of the rheumatic diseases	2003
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Loss of a single allele of SHIP exacerbates the immunopathology of Pten heterozygous mice JL Moody, CG Pereira, A Magil, MJ Fritzler, FR Jirik	Genes and Immunity	2003
Chromatin Specificity of Anti-Double-Stranded DNA Antibodies and a Role for Arg Residues in the Third Complementarity-Determining Region of the Heavy Chain AM Guth, X Zhang, D Smith, T Detanico, LJ Wysocki	Journal of immunology (Baltimore, Md. : 1950)	2003
CD4 + T Cells from (New Zealand Black × New Zealand White)F 1 Lupus Mice and Normal Mice Immunized Against Apoptotic Nucleosomes Recognize Similar Th Cell Epitopes in the C Terminus of Histone H3 S Fournel, S Neichel, H Dali, S Farci, B Maillère, JP Briand, S Muller	Journal of immunology (Baltimore, Md. : 1950)	2003
Anti-chromatin (anti-nucleosome) autoantibodies RW Burlingame, R Cervera	Autoimmunity Reviews	2002
Molecular signatures of antinuclear antibodies—contributions of heavy chain CDR residues L Chen, S Chang, C Mohan	Molecular Immunology	2002
A genetic analysis of lupus AN Theofilopoulos, DH Kono	Allergy	2002
Clinical value of anti-ssDNA (denatured DNA) autoantibody test M Teodorescu	Clinical and Applied Immunology Reviews	2002
Cutaneous lupus erythematosus: a review P Patel, V Werth	Dermatologic Clinics	2002
Anti–DNA B Cells in MRL/lpr Mice Show Altered Differentiation and Editing Pattern Y Li, H Li, D Ni, M Weigert	Journal of Experimental Medicine	2002
Triggers for anti-chromatin autoantibody production in SLE JW Dieker, J der Vlag, JH Berden	Lupus	2002
Naturally Processed Chromatin Peptides Reveal a Major Autoepitope That Primes Pathogenic T and B Cells of Lupus A Kaliyaperumal, MA Michaels, SK Datta	Journal of immunology (Baltimore, Md. : 1950)	2002
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Anti-subnucleosome reactivities in systemic lupus erythematosus (SLE) patients and their first-degree relatives C Mohan, F Liu, C Xie, RC Williams	Clinical & Experimental Immunology	2001
Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone bxsb mice KM Pollard, DL Pearson, P Hultman, TN Deane, U Lindh, DH Kono	Environmental Health Perspectives	2001
Telomeres, Telomerase, and Lupus: The Long and Short of It V Rus, CS Via	Clinical Immunology	2001
The Role of αβ + T Cells and Homeostatic T Cell Proliferation in Y-Chromosome-Associated Murine Lupus BR Lawson, SI Koundouris, M Barnhouse, W Dummer, R Baccala, DH Kono, AN Theofilopoulos	Journal of immunology (Baltimore, Md. : 1950)	2001
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The role of nucleosomes in lupus Z Amoura, S Koutouzov, JC Piette	Current Opinion in Rheumatology	2000
Lessons from the NZM2410 Model and Related Strains L Morel, EK Wakeland	International Reviews of Immunology	2000
Frequency and significance of antibodies to chromatin in autoimmune hepatitis type I L Li, M Nishioka, DY Huang, M Nishioka	Journal of Gastroenterology and Hepatology	2000
Genetics of Systemic Autoimmunity in Mouse Models of Lupus DH Kono, AN Theofilopouuos	International Reviews of Immunology	2000
Xenobiotic Acceleration of Idiopathic Systemic Autoimmunity in Lupus-Prone BXSB Mice KM Pollard, DL Pearson, P Hultman, TN Deane, U Lindh, DH Kono	Environmental Health Perspectives	2000
APOPTOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS F Andrade, L Casciola-Rosen, A Rosen	Rheumatic Disease Clinics of North America	2000
Nucleosomes are major T and B cell autoantigens in systemic lupus erythematosus A Bruns, S Bläss, G Hausdorf, GR Burmester, F Hiepe	Arthritis & Rheumatism	2000
Anti-nucleosome antibodies - a novel test in systemic lupus erythematosus P Horak, Z Hermanova, V Scudla, L Faltynek, Z Pospisil	Biomedical Papers	2000
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Induction of anti-DNA antibodies by immunization with anti-DNA antibodies: mechanism and characterization F Satake, N Watanabe, N Miyasaka, Y Kanai, T Kubota	Lupus	2000
Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo L R.-Borlado, C Redondo, B Alvarez, C Jimenez, LM Criado, J Flores, MA Marcos, C Martinez-A, D Balomenos, AC Carrera	The FASEB Journal	2000
Immunobiology of Bacterial CpG-DNA H Wagner		2000
Identification of a Minimal T Cell Epitope Recognized by Antinucleosome Th Cells in the C-Terminal Region of Histone H4 P Decker, AL Moal, JP Briand, S Muller	Journal of immunology (Baltimore, Md. : 1950)	2000
Development of Lupus in BXSB Mice Is Independent of IL-4 DH Kono, D Balomenos, MS Park, AN Theofilopoulos	Journal of immunology (Baltimore, Md. : 1950)	2000
Mechanisms of Action of Intravenous Immunoglobulin (IVIG) MD Kazatchkine, B Bellon, SV Kaveri	Multiple sclerosis (Houndmills, Basingstoke, England)	2000
Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies C Mohan, L Morel, P Yang, H Watanabe, B Croker, G Gilkeson, EK Wakeland	Journal of Clinical Investigation	1999
Autoreactive T cells in murine lupus J Craft, S Peng, T Fujii, M Okada, S Fatenejad	Immunologic Research	1999
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Keratinocytes from patients with lupus erythematosus show enhanced cytotoxicity to ultraviolet radiation and to antibody-mediated cytotoxicity F Furukawa, T Itoh, H Wakita, H Yagi, Y Tokura, DA Norris, M Takigawa	Clinical & Experimental Immunology	1999
Antibody production in autoimmune BXSB mice. I. CD40L-expressing B cells need fewer signals for polyclonal antibody synthesis S Blossom, KM Gilbert	Clinical & Experimental Immunology	1999
Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity KM Pollard, DL Pearson, P Hultman, B Hildebrandt, DH Kono	Environmental Health Perspectives	1999
Autoreactive T cells in murine lupus: Origins and Roles in Autoantibody Production J Craft, S Peng, T Fujii, M Okada, S Fatenejad	Immunologic Research	1999
Apoptotic Cells as Immunogen and Antigen in the Antiphospholipid Syndrome JS Levine, JS Koh, R Subang, J Rauch	Experimental and Molecular Pathology	1999
CD4 TCRBV CDR3 Analysis in prevalent SLE Cases from two ethnic Groups PA Fraser, LY Lu, K DeCeulaer, PH Schur, D Fici, Z Awdeh, WZ Ding, E Levitan, R Lew, G Uko, C Gonzalez	Lupus	1999
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Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes C Mohan, E Alas, L Morel, P Yang, EK Wakeland	Journal of Clinical Investigation	1998
Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice D Balomenos, R Rumold, AN Theofilopoulos	Journal of Clinical Investigation	1998
Anti-DNA, antihistone, and antinucleosome antibodies in systemic lupus erythematosus and drug-induced lupus GQ Shen, Y Shoenfeld, JB Peter	Clinical Reviews in Allergy & Immunology	1998
Early anti-nucleosome autoantibodies from a single MRL +/+ mouse: fine specificity, V gene structure and pathogenicity F Jovelin, G Mostoslavsky, Z Amoura, H Chabre, D Gilbert, D Eilat, JF Bach, S Koutouzov	European Journal of Immunology	1998
What is the primary antigen in systemic lupus erythematosus? T Kubota	Japanese Journal of Rheumatology	1998
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Isolation and Characterization of Apoptotic Nucleosomes, Free and Complexed with Lupus Autoantibody Generated During Hybridoma B-cell Apoptosis A Cabrespines, D Laderach, C Lebossé, JF Bach, S Koutouzov	Journal of Autoimmunity	1998
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Influence of antigen organization on the development of lupus autoantibodies S Fatenejad, M Bennett, J Moslehi, J Craft	Arthritis & Rheumatism	1998
Pathogenesis of autoimmunity in alphabeta T cell-deficient lupus-prone mice SL Peng, J Cappadona, JM McNiff, MP Madaio, MJ Owen, AC Hayday, J Craft	Clinical & Experimental Immunology	1998
Structural models of antibody variable fragments: a method for investigating binding mechanisms S Petit, F Brard, G Coquerel, G Perez, F Tron	Journal of Computer-Aided Molecular Design	1998
Autoimmunity caused by disruption of central T cell tolerance. A murine model of drug-induced lupus A Kretz-Rommel, SR Duncan, RL Rubin	Journal of Clinical Investigation	1997
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Systemic lupus: basic mechanisms and prospects for specific immunotherapy SK Datta	Japanese Journal of Rheumatology	1997
Circulating plasma levels of nucleosomes in patients with systemic lupus erythematosus. Correlation with serum antinucleosome antibody titers and absence of clear association with disease activity Z Amoura, JC Piette, H Chabre, P Cacoub, T Papo, B Wechsler, JF Bach, S Koutouzov	Arthritis & Rheumatism	1997
The Regulation of Murine Lupus SL Peng, J Craft	Annals of the New York Academy of Sciences	1997
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Deposition of antibodies to the collagen-like region of C1Q in renal glomeruli of patients with proliferative lupus glomerulonephritis M Mannik, MH Wener	Arthritis & Rheumatism	1997
Nucleosome-driven Autoimmune Response in Lupus Pathogenic T Helper Cell Epitopes and Costimulatory Signals SK Datta, A Kaliyaperumal	Annals of the New York Academy of Sciences	1997
New clues to systemic lupus JF Bach, S Koutouzov	The Lancet	1997
G1 arrest and high expression of cyclin kinase and apoptosis inhibitors in accumulated activated/memory phenotype CD4+ cells of older lupus mice H Sabzevari, S Propp, DH Kono, AN Theofilopoulos	European Journal of Immunology	1997
Self antigens and epitope spreading in systemic autoimmunity J Craft, S Fatenejad	Arthritis & Rheumatism	1997
CD40-CD40 ligand interaction in autoimmune disease SK Datta, SL Kalled	Arthritis & Rheumatism	1997
The role of antibodies to DNA in systemic lupus erythematosus— A review and introduction to an international workshop on DNA antibodies held in London, May 1996 DA Isenberg, CT Ravirajan, A Rahman, J Kalsi	Lupus	1997
The Clinical Utility of Antihistone Antibodies RW Burlingame	Clinics in Laboratory Medicine	1997
T cells of lupus and molecular targets for immunotherapy S K Datta, A Kaliyaperumal, A Desai-Mehta	Journal of Clinical Immunology	1997
Genetic dissection of lupus nephritis in murine models of SLE E K Wakeland, L Morel, C Mohan, M Yui	Journal of Clinical Immunology	1997
Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production A Desai-Mehta, L Lu, R Ramsey-Goldman, SK Datta	Journal of Clinical Investigation	1996
Heterogeneity and clinical significance of glomerular-binding antibodies in systemic lupus erythematosus JB Lefkowith, M Kiehl, J Rubenstein, R DiValerio, K Bernstein, L Kahl, RL Rubin, M Gourley	Journal of Clinical Investigation	1996
Clinical relevance of autoantibodies in systemic rheumatic diseases MJ Fritzler	Molecular Biology Reports	1996
Binding of nucleosomes to a cell surface receptor: Redistribution and endocytosis in the presence of lupus antibodies S Kontouzov, A Cabrespines, Z Amoura, H Chabre, C Lotton, JF Bach	European Journal of Immunology	1996
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Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus A Kaliyaperumal, C Mohan, W Wu, SK Datta	Journal of Experimental Medicine	1996
MOLECULAR BIOLOGY OF AUTOANTIGENS IN RHEUMATIC DISEASES C Galperin, PS Leung, ME Gershwin	Rheumatic Disease Clinics of North America	1996
Autoantibody to the nucleosome subunit (H2A-H2B)-DNA is an early and ubiquitous feature of lupus-like conditions RW Burlingame, RL Rubin	Molecular Biology Reports	1996
Nephritogenic autoantibodies in lupus: current concepts and continuing controversies JB Lefkowith, GS Gilkeson	Arthritis & Rheumatism	1996
Manual of Biological Markers of Disease WJ van Venrooij, RN Maini		1996
The interaction of C-reactive protein and serum amyloid P component with nuclear antigens TW Clos	Molecular Biology Reports	1996
T cells in murine lupus: propagation and regulation of disease SL Peng, J Craft	Molecular Biology Reports	1996
Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus A Desai-Mehta, C Mao, S Rajagopalan, T Robinson, SK Datta	Journal of Clinical Investigation	1995
Induction and natural occurrence of serum nucleosomal DNA in autoimmune MRL/lpr/lpr mice: its relation to apoptosis in the thymus Y Kanai, S Kyuwa, K Miura, Y Kurosawa	Immunology Letters	1995
Mechanisms of the pathogenic autoimmune response in lupus: Prospects for specific immunotherapy SK Datta, C Mohan, A Desai-Mehta	Immunologic Research	1995
No evidence for an independent role of anti-heparan sulphate reactivity apart from anti-DNA in lupus nephritis MN Hylkema, IV Zwet, C Kramers, MC Bruggen, AJ Swaak, JH Berden, RJ Smeenk	Clinical & Experimental Immunology	1995
Apoptosis, nucleosomes, and nephritis in systemic lupus erythematosus WJ Tax, C Kramers, MC van Bruggen, JH Berden	Kidney International	1995
Inquiry into Murine and Human Lupus DM Kunman, AD Steinberg	Immunological Reviews	1995
Presence of nucleosome-restricted antibodies in patients with systemic lupus erythematosus H Chabre, Z Amoura, JC Piette, P Godeau, JF Bach, S Koutouzov	Arthritis & Rheumatism	1995
Autoantibodies to histone, DNA and nucleosome antigens in canine systemic lupus erythematosus M Monestier, KE Novick, ET Karam, L Chabanne, JC Monier, D Rigal	Clinical & Experimental Immunology	1995
Expression of the B cell repertoire in lpr mice; abnormal expansion of a few VHJ558 germ-line genes ME Alarcón-Riquelme, C Fernández	Clinical & Experimental Immunology	1995
The basis of autoimmunity: Part I mechanisms of aberrant self-recognition AN Theofilopoulos	Immunology Today	1995
No evidence for an independent role of anti-heparan sulphate reactivity apart from anti-DNA in lupus nephritis. Hylkema MN, Zwet IV, Kramers C, Van Bruggen MC, Swaak AJ, Berden JH, Smeenk RJ	Clinical & Experimental Immunology	1995
Autoantibodies to histone, DNA and nucleosome antigens in canine systemic lupus erythematosus. Monestier M, Novick KE, Karam ET, Chabanne L, Monier JC, Rigal D	Clinical & Experimental Immunology	1995
Expression of the B cell repertoire in lpr mice; abnormal expansion of a few VHJ558 germ-line genes. Alarcón-Riquelme ME, Fernández C	Clinical & Experimental Immunology	1995
The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus RW Burlingame, ML Boey, G Starkebaum, RL Rubin	Journal of Clinical Investigation	1994
Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo C Kramers, MN Hylkema, MC van Bruggen, R de Lagemaat, HB Dijkman, KJ Assmann, RJ Smeenk, JH Berden	Journal of Clinical Investigation	1994
Nucleosome-restricted antibodies are detected before anti-dsdna and/or antihistone antibodies in serum of mrl-mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria Z Amoura, H Chabre, S Koutouzov, C Lotton, A Cabrespines, JF Bach, L Jacob	Arthritis & Rheumatism	1994
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes LA Casciola-Rosen, G Anhalt, A Rosen	Journal of Experimental Medicine	1994
Lupus susceptibility loci in New Zealand mice DH Kono, RW Burlingame, DG Owens, A Kuramochi, RS Balderas, D Balomenos, AN Theofilopoulos	Proceedings of the National Academy of Sciences	1994
A new ELISA for the detection of anti-heparan sulfate reactivity, using photobiotinylated antigen MN Hylkema, C Kramers, TJ der Wal, MC Bruggen, AJ Swaak, JH Berden, RJ Smeenk	Journal of Immunological Methods	1994
Autoantibodies MH Lessof, SP Asper	American Heart Journal	1960

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