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Citations to this article

Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis.
M C Cid, … , A S Fauci, H K Kleinman
M C Cid, … , A S Fauci, H K Kleinman
Published March 1, 1993
Citation Information: J Clin Invest. 1993;91(3):977-985. https://doi.org/10.1172/JCI116319.
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Research Article Article has an altmetric score of 6

Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis.

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Abstract

Angiogenesis is an important process in chronic inflammatory diseases. We observed that sera from patients with systemic vasculitis stimulated angiogenesis in an in vitro model using human umbilical vein endothelial cells cultured on a basement membrane (Matrigel) substrate. After 40% ammonium sulfate precipitation, angiogenic activity remained in the low molecular weight fraction and could be inactivated by heat. SDS-page of serum FPLC fractions exhibiting maximal angiogenic activity demonstrated two prominent species of 45 and 16-20 kD in patients' sera. These bands were much less apparent in sera obtained from control subjects. Amino-terminal sequencing of the 45-kD protein demonstrated that it was haptoglobin. Purified haptoglobin stimulated angiogenesis in a dose-dependent manner. The angiogenic activity of vasculitis patients' sera was partially inhibited by an antihaptoglobin antibody. Furthermore, serum haptoglobin levels in vasculitis patients correlated both with disease and angiogenic activity. Haptoglobin angiogenic activity was confirmed in two in vivo models using an implanted disc and a subcutaneous injection of basement membrane. Stimulation of angiogenesis is a newly recognized biological function of haptoglobin. The increased levels of haptoglobin found in chronic inflammatory conditions may play an important role in tissue repair. In systemic vasculitis, haptoglobin might also compensate for ischemia by promoting development of collateral vessels.

Authors

M C Cid, D S Grant, G S Hoffman, R Auerbach, A S Fauci, H K Kleinman

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Citations to this article in year 2015 (4)

Title and authors Publication Year
Preeclampsia and Diabetes
TL Weissgerber, LM Mudd
Current Diabetes Reports 2015
Myoblast-conditioned media improve regeneration and revascularization of ischemic muscles in diabetic mice
M Kozakowska, J Kotlinowski, A Grochot-Przeczek, M Ciesla, B Pilecki, R Derlacz, J Dulak, A Jozkowicz
Stem Cell Research & Therapy 2015
Understanding the role of haptoglobin in psoriasis: effects of ultraviolet B
B Maresca, S Lembo, F Ayala, N Balato, RD Caprio, M Mattii, A Raimondo, M Schiattarella, P Abrescia, MS Spagnuolo, L Cigliano, A Balato
Clinical and Experimental Dermatology 2015
Single chain precursor prohaptoglobin promotes angiogenesis by upregulating expression of vascular endothelial growth factor (VEGF) and VEGF receptor2
MK Oh, HJ Park, JH Lee, HM Bae, IS Kim
FEBS Letters 2015

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Referenced in 7 patents
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