We hypothesize that in patients with insulin-dependent diabetes mellitus (IDDM), recent antecedent iatrogenic hypoglycemia is a major cause of hypoglycemia-associated autonomic failure, a disorder distinct from classical diabetic autonomic neuropathy (CDAN), and that hypoglycemia-associated autonomic failure, by reducing both symptoms of and defense against developing hypoglycemia, results in recurrent iatrogenic hypoglycemia, thus creating a vicious cycle. We used the hyperinsulinemic (12.0 pmol.kg-1.min-1) stepped hypoglycemic clamp technique to assess autonomic and symptomatic responses to hypoglycemia and the insulin infusion test (4.0 pmol.kg-1.min-1) to assess defense against hypoglycemia on mornings before and after clamped afternoon hypoglycemia (approximately 2.8 mmol/liter) and hyperglycemia (approximately 11.1 mmol/liter) in patients with IDDM. Compared with nondiabetic subjects, IDDM with or without CDAN exhibited reduced epinephrine (P = 0.0222 and 0.0040) and pancreatic polypeptide (P = 0.0083 and 0.0056) responses to hypoglycemia. After afternoon hypoglycemia, lower plasma glucose concentrations were required to elicit autonomic and symptomatic responses during morning hypoglycemic clamps in patients without CDAN. At the 2.8 mmol/liter step, mean (+/- SE) epinephrine levels were 1,160 +/- 270 and 2,040 +/- 270 pmol/liter (P = 0.0060), pancreatic and total symptom scores were 22 +/- 3 and 41 +/- 7 (P = 0.0475) after afternoon hypoglycemia and hyperglycemia, respectively. During morning insulin infusion tests after afternoon hypoglycemia, nadir plasma glucose concentrations were 2.6 +/- 0.2 mmol/liter compared with 3.3 +/- 0.3 mmol/liter (P < 0.001) at the corresponding time points after afternoon hyperglycemia. Thus, we conclude: (a) elevated glycemic thresholds for autonomic responses to hypoglycemia are a feature of IDDM per se, not classical diabetic autonomic neuropathy; and (b) a single episode of afternoon hypoglycemia results in both elevated glycemic thresholds for autonomic and symptomatic responses to hypoglycemia and impaired physiological defense against hypoglycemia the next morning in IDDM.
S E Dagogo-Jack, S Craft, P E Cryer
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Effects of insulin‐induced hypoglycaemia on cardiac function in people with type 1 and type 2 diabetes and people without diabetes
Fabricius TW, Verhulst C, Svensson CH, Wienberg M, Duijnhouwer AL, Tack CJ, Kristensen PL, de Galan BE, Pedersen\u2010Bjergaard U |
Diabetes, Obesity & Metabolism | 2025 |
Electrocardiograpic responses during spontaneous hypoglycaemia in people with type 1 diabetes and impaired awareness of hypoglycaemia
Novodvorsky P, Bernjak A, Downs E, Smith A, Arshad MF, Oprescu AI, Jacques RM, Lee J, Heller SR, Iqbal A |
Diabetic Medicine | 2025 |
The impact of prior exposure to hypoglycaemia on the inflammatory response to a subsequent hypoglycaemic episode.
Verhulst CEM, van Heck JIP, Fabricius TW, Stienstra R, Teerenstra S, McCrimmon RJ, Tack CJ, Pedersen-Bjergaard U, de Galan BE |
Cardiovascular Diabetology | 2024 |
Evaluating the effectiveness of a novel somatostatin receptor 2 antagonist, ZT-01, for hypoglycemia prevention in a rodent model of type 2 diabetes
D\u2019Souza NC, Aiken JA, Hoffman EG, Atherley SC, Champsi S, Aleali N, Shakeri D, El-Zahed M, Akbarian N, Nejad-Mansouri M, Bavani PZ, Liggins RL, Chan O, Riddell MC |
Frontiers in pharmacology | 2024 |
Neurological dysfunction screening in a cohort of adolescents with type 1 diabetes: a six-year follow-up
Tinti D, Canavese C, Nobili C, Marcotulli D, Daniele E, Rabbone I, de Sanctis L |
Frontiers in Medicine | 2024 |
Hybrid Closed Loop in Adults With Type 1 Diabetes and Severely Impaired Hypoglycemia Awareness
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The Journal of Clinical Endocrinology and Metabolism | 2024 |
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Frontiers in public health | 2023 |
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Shana Warner, Yufei Dai, Nicole Sheanon, Michael Yao, Rebecca Cason, Shahriar Arbabi, Shailendra Patel, Diana Lindquist, Jason Winnick |
JCI Insight | 2023 |
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Arnaud Kaze, Matthew Yuyun, Rexford Ahima, Michael Rickels, Justin Echouffo-Tcheugui |
JCI Insight | 2022 |
Evaluation of Clinical Metrics for Identifying Defective Physiologic Responses to Hypoglycemia in Long-Standing Type 1 Diabetes
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The Journal of clinical endocrinology and metabolism | 2022 |
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Diabetologia | 2022 |
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BMJ Open | 2022 |
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JCI Insight | 2021 |
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American journal of physiology. Endocrinology and metabolism | 2021 |
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Beyond A1C—Standardization of Continuous Glucose Monitoring Reporting: Why It Is Needed and How It Continues to Evolve
RW Beck, RM Bergenstal |
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Neurochemistry International | 2021 |
Diabetes education in pediatrics: How to survive diabetes
B Ergun-Longmire, E Clemente, P Vining-Maravolo, C Roberts, K Buth, DE Greydanus |
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Improved Estimation of Glycated Hemoglobin from Continuous Glucose Monitoring and Past Glycated Hemoglobin Data
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Diabetes Technology & Therapeutics | 2021 |
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2021 | |
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Journal of Clinical Investigation | 2020 |
Diabetes: from Research to Clinical Practice: Volume 4
S Islam |
2020 | |
Diabetes: from Research to Clinical Practice: Volume 4
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2020 | |
Diabetes: from Research to Clinical Practice: Volume 4
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2020 | |
Metabolomic, hormonal and physiological responses to hypoglycemia versus euglycemia during exercise in adults with type 1 diabetes
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BMJ Open Diabetes Research & Care | 2020 |
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M Ibrahim, J Baker, A Cahn, RH Eckel, NA Sayed, AH Fischl, P Gaede, RD Leslie, S Pieralice, D Tuccinardi, P Pozzilli, B Richelsen, E Roitman, E Standl, Y Toledano, J Tuomilehto, SL Weber, GE Umpierrez |
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Hypoglycemia unawareness and autonomic dysfunction in diabetes: Lessons learned and roles of diabetes technologies
YK Lin, SJ Fisher, R PopBusui |
Journal of Diabetes Investigation | 2020 |
Hypoglycaemia and cardiac arrhythmias in diabetes
A Andersen, PG Jørgensen, FK Knop, T Vilsbøll |
Therapeutic Advances in Endocrinology and Metabolism | 2020 |
A Human Randomized Controlled Trial Comparing Metabolic Responses to Single and Repeated Hypoglycemia in Type 1 Diabetes
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The Journal of clinical endocrinology and metabolism | 2020 |
Severe Hypoglycemia: Is It Still a Threat for Children and Adolescents With Type 1 Diabetes?
T Urakami |
Frontiers in Endocrinology | 2020 |
Blood Glucose Levels
L Szablewski |
2020 | |
Experimental Models of Impaired Hypoglycaemia-Associated Counter-Regulation
A Sankar, T Khodai, AD McNeilly, RJ McCrimmon, SM Luckman |
Trends in endocrinology and metabolism: TEM | 2020 |
Restoration of Hypoglycemia Awareness Alters Brain Activity in Type 1 Diabetes
M Nwokolo, SA Amiel, O ODaly, IA Macdonald, FO Zelaya, P Choudhary |
Diabetes care | 2020 |
Definitions and reporting of hypoglycaemia in trials of long-acting insulin analogues in people with type 1 diabetes mellitus
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Cochrane Database of Systematic Reviews | 2020 |
Novel dominant K ATP channel mutations in infants with congenital hyperinsulinism: Validation by in vitro expression studies and in vivo carrier phenotyping
KE Boodhansingh, B Kandasamy, L Mitteer, S Givler, DD Leon, SL Shyng, A Ganguly, CA Stanley |
American journal of medical genetics. Part A | 2019 |
The Association of Biochemical Hypoglycemia with the Subsequent Risk of a Severe Hypoglycemic Event: Analysis of the DCCT Data Set
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Diabetes Technology & Therapeutics | 2019 |
Novel Preparations of Glucagon for the Prevention and Treatment of Hypoglycemia
CP Hawkes, DD Leon, MR Rickels |
Current Diabetes Reports | 2019 |
Impaired Awareness of Hypoglycemia Disrupts Blood Flow to Brain Regions Involved in Arousal and Decision Making in Type 1 Diabetes
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Diabetes care | 2019 |
Exercise Management for Young People With Type 1 Diabetes: A Structured Approach to the Exercise Consultation
T Chetty, V Shetty, PA Fournier, P Adolfsson, TW Jones, EA Davis |
Frontiers in Endocrinology | 2019 |
Long-Term Effectiveness of Continuous Subcutaneous Insulin Infusion in the Prevention of Hypoglycemia in Adults with Type 1 Diabetes
JC Summers, EM Briganti, ZA Fitzgerald, LN Lambers, ND Cohen |
Diabetes Technology & Therapeutics | 2019 |
Assoziation von Hypoglykämiewahrnehmungsstörung und Veränderungen des Gehirns: Typ-1-Diabetes
M Jecht |
Der Diabetologe | 2019 |
Acidosis mediates recurrent hypoglycemia-induced increase in ischemic brain injury in treated diabetic rats
AK Rehni, V Shukla, MA Perez-Pinzon, KR Dave |
Neuropharmacology | 2018 |
Impact of Hypoglycemia on Brain Metabolism During Diabetes
AK Rehni, KR Dave |
Molecular Neurobiology | 2018 |
Fear of hypoglycaemia and its relation to hypoglycaemia awareness and symptom intensity in Type 1 diabetes
H Hatle, MR Bjørgaas, TB Rø, SE Olsen, BO Åsvold |
Diabetes Research and Clinical Practice | 2018 |
Hypoglycemic Exposure and Risk of Asymptomatic Hypoglycemia in Type 1 Diabetes Assessed by Continuous Glucose Monitoring
MM Henriksen, HU Andersen, B Thorsteinsson, U Pedersen-Bjergaard |
The Journal of clinical endocrinology and metabolism | 2018 |
Prevention and Management of Severe Hypoglycemia and Hypoglycemia Unawareness: Incorporating Sensor Technology
P Lucidi, F Porcellati, GB Bolli, CG Fanelli |
Current Diabetes Reports | 2018 |
Stable Liquid Glucagon: Beyond Emergency Hypoglycemia Rescue
LM Wilson, JR Castle |
Journal of diabetes science and technology | 2018 |
The impact of hypoglycaemia awareness status on regional brain responses to acute hypoglycaemia in men with type 1 diabetes
JT Dunn, P Choudhary, MM Teh, I Macdonald, KF Hunt, PK Marsden, SA Amiel |
Diabetologia | 2018 |
Hypoglycaemia in diabetes: do we think enough of the cause? An observational study on prevalence and causes of hypoglycaemia among patients with type 2 diabetes in an out-patient setting in Sri Lanka
HA Dissanayake, GS Keerthisena, KK Gamage, JH Liyanage, IR Ihalagama, WM Wijetunga, TA Tillekaratne, GW Katulanda, P Katulanda |
BMC Endocrine Disorders | 2018 |
Diabetes Complications, Comorbidities and Related Disorders
E Bonora, R DeFronzo |
2018 | |
Pheochromocytomas, Paragangliomas and Disorders of the Sympathoadrenal System
L Landsberg |
2018 | |
Evaluation of Hypoglycaemia with Non-Invasive Sensors in People with Type 1 Diabetes and Impaired Awareness of Hypoglycaemia
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Scientific Reports | 2018 |
Insulin regulates GLUT4 in the ventromedial hypothalamus to restore the sympathoadrenal response to hypoglycemia in diabetic rats
R Agrawal, A Vieira-de-Abreu, G Durupt, C Taylor, O Chan, SJ Fisher |
American journal of physiology. Endocrinology and metabolism | 2018 |
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MM Henriksen, HU Andersen, B Thorsteinsson, U Pedersen-Bjergaard |
Diabetic Medicine | 2018 |
Hypoglycaemia and gastric emptying
CS Marathe, JA Marathe, CK Rayner, P Kar, KL Jones, M Horowitz |
Diabetes, obesity & metabolism | 2018 |
Glucose autoregulation is the dominant component of the hormone-independent counterregulatory response to hypoglycemia in the conscious dog
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American journal of physiology. Endocrinology and metabolism | 2017 |
Opioid Receptor Activation Impairs Hypoglycemic Counterregulation in Humans
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Diabetes | 2017 |
Recent Exposure to Hypoglycemia Increases Glucose Variability Following a Hyper/Hypoglycemic Metabolic Challenge in T1D
C Fabris, LS Farhy, SM Anderson, RM Nass, BP Kovatchev, MD Breton |
Journal of diabetes science and technology | 2017 |
Appetite and Food Intake: Central Control, Second Edition
R Harris |
Appetite and Food Intake: Central Control, Second Edition | 2017 |
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PloS one | 2017 |
Drug Delivery: An Integrated Clinical and Engineering Approach
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Drug Delivery: An Integrated Clinical and Engineering Approach | 2017 |
Hypoglycemic episodes in cats with diabetes mellitus: 30 cases (2013–2015)
KA Viebrock, J Dennis |
Journal of Feline Medicine & Surgery | 2017 |
The Yin and Yang Between Plasma Glucose Levels and Cortisol Replacement Therapy in Schmidt’s Syndrome
CA Newton, E Sheehan, K Wyne, K Cusi, J Leey, HK Ghayee |
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Diabetologia | 2017 |
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Diabetes Technology & Therapeutics | 2017 |
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Diabetes Technology & Therapeutics | 2017 |
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Diabetes Technology & Therapeutics | 2017 |
Hypoglycemia-Associated EEG Changes Following Antecedent Hypoglycemia in Type 1 Diabetes Mellitus
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Diabetes | 2017 |
Development and Validation of a Questionnaire Evaluating Impaired Hypoglycemia Awareness among Adult Filipino Patients with Type 2 Diabetes Mellitus
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2017 | |
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Diabetologia | 2017 |
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Journal of Clinical Investigation | 2016 |
Comparative Pharmacokinetic/Pharmacodynamic Study of Liquid Stable Glucagon Versus Lyophilized Glucagon in Type 1 Diabetes Subjects
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Journal of diabetes science and technology | 2016 |
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G Öz, M DiNuzzo, A Kumar, A Moheet, A Khowaja, K Kubisiak, LE Eberly, ER Seaquist |
Journal of Cerebral Blood Flow & Metabolism | 2016 |
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee |
Endocrinology: Adult and Pediatric | 2016 |
Principles of Diabetes Mellitus
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Principles of Diabetes Mellitus | 2016 |
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M Senthilkumaran, XF Zhou, L Bobrovskaya |
International Journal of Endocrinology | 2016 |
A randomized clinical trial comparing basal insulin peglispro and insulin glargine, in combination with prandial insulin lispro, in patients with type 1 diabetes: IMAGINE 1
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Diabetes Obesity and Metabolism | 2016 |
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Endocrinology | 2016 |
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Diabetes | 2015 |
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World journal of diabetes | 2015 |
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Brain glucose metabolism during hypoglycemia in type 1 diabetes: insights from functional and metabolic neuroimaging studies
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Cellular and Molecular Life Sciences | 2015 |
Dual-hormone treatment with insulin and glucagon in patients with type 1 diabetes: Dual-Hormone Treatment in Type 1 Diabetes
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Diabetes/Metabolism Research and Reviews | 2015 |
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JS Yun, SH Ko |
The Korean Journal of Internal Medicine | 2015 |
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Diabetes Obesity and Metabolism | 2015 |
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Diabetes | 2015 |
International Textbook of Diabetes Mellitus: DeFronzo/International Textbook of Diabetes Mellitus, Fourth Edition
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Plasma insulin profiles after subcutaneous injection: how close can we get to physiology in people with diabetes?
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Diabetes Obesity and Metabolism | 2015 |
Recurrent Hypoglycemia Increases Anxiety and Amygdala Norepinephrine Release During Subsequent Hypoglycemia
E McNay |
Frontiers in Endocrinology | 2015 |
Philip E. Cryer, MD: Seminal Contributions to the Understanding of Hypoglycemia and Glucose Counterregulation and the Discovery of HAAF (Cryer Syndrome)
S Dagogo-Jack |
Diabetes care | 2015 |
Impaired Awareness of Hypoglycemia in Adults With Type 1 Diabetes Is Not Associated With Autonomic Dysfunction or Peripheral Neuropathy
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Diabetes care | 2015 |
Endocrinology and Diabetes
R Ajjan, SM Orme |
2015 | |
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VH Routh, L Hao, AM Santiago, Z Sheng, C Zhou |
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E Brutsaert, M Carey, J Zonszein |
Journal of Diabetes and its Complications | 2014 |
Defective Glucagon Secretion During Hypoglycemia After Intrahepatic But Not Nonhepatic Islet Autotransplantation: Autoislets and Defective Glucagon Secretion
MD Bellin, S Parazzoli, E Oseid, LD Bogachus, C Schuetz, ME Patti, T Dunn, T Pruett, AN Balamurugan, B Hering, G Beilman, DE Sutherland, RP Robertson |
American Journal of Transplantation | 2014 |
Increased Risk of Severe Hypoglycemic Events with Increasing Frequency of Non-severe Hypoglycemic Events in Patients with Type 1 and Type 2 Diabetes
S Sreenan, M Andersen, BL Thorsted, ML Wolden, M Evans |
Diabetes Therapy | 2014 |
Hypoglycemia-Associated Changes in the Electroencephalogram in Patients With Type 1 Diabetes and Normal Hypoglycemia Awareness or Unawareness
AS Sejling, TW Kjær, U Pedersen-Bjergaard, SS Diemar, CS Frandsen, L Hilsted, J Faber, JJ Holst, L Tarnow, MN Nielsen, LS Remvig, B Thorsteinsson, CB Juhl |
Diabetes | 2014 |
Diabetische Notfallsituationen – die Hypoglykämie
T Siegmund, PM Schumm-Draeger |
Der Diabetologe | 2014 |
Clinical Autonomic Dysfunction
J Colombo, R Arora, NL DePace, AI Vinik |
2014 | |
Diabetologie kompakt
H Schatz, AF Pfeiffer |
2014 | |
Glycaemic variability in diabetes: a tool for assessing the quality of glycaemic control and the risk of complications
VV Klimontov, NE Myakina |
Diabetes mellitus | 2014 |
Increased brain transport and metabolism of acetate in hypoglycemia unawareness
BI Gulanski, HM de Feyter, KA Page, R Belfort-DeAguiar, GF Mason, DL Rothman, RS Sherwin |
The Journal of clinical endocrinology and metabolism | 2013 |
Increased brain lactate concentrations without increased lactate oxidation during hypoglycemia in type 1 diabetic individuals
HM de Feyter, GF Mason, GI Shulman, DL Rothman, KF Petersen |
Diabetes | 2013 |
Role of Synaptic Plasticity and EphA5-EphrinA5 Interaction Within the Ventromedial Hypothalamus in Response to Recurrent Hypoglycemia
B Szepietowska, TL Horvath, RS Sherwin |
Diabetes | 2013 |
Lactate and the Mechanism of Hypoglycemia-Associated Autonomic Failure in Diabetes
AM Arbelaez, PE Cryer |
Diabetes | 2013 |
2. Hypoglycemia Detection
Routh VH, Donovan CM, Ritter S |
Translational endocrinology & metabolism | 2013 |
Diabetic status and the relation of the three domains of glycemic control to mortality in critically ill patients: an international multicenter cohort study
JS Krinsley, M Egi, A Kiss, AN Devendra, P Schuetz, PM Maurer, MJ Schultz, RT van Hooijdonk, M Kiyoshi, IM Mackenzie, D Annane, P Stow, SA Nasraway, S Holewinski, U Holzinger, JC Preiser, JL Vincent, R Bellomo |
Critical Care | 2013 |
Hypoglycemia in Patients with Type 1 Diabetes: Epidemiology, Pathogenesis, and Prevention
O Awoniyi, R Rehman, S Dagogo-Jack |
Current Diabetes Reports | 2013 |
The Role of Bromocriptine-QR in the Management of Type 2 Diabetes Expert Panel Recommendations
AJ Garber, L Blonde, ZT Bloomgarden, Y Handelsman, S Dagogo-Jack |
Endocrine Practice | 2013 |
Mechanisms of Hypoglycemia-Associated Autonomic Failure in Diabetes
DL Longo, PE Cryer |
New England Journal of Medicine | 2013 |
Hypoglycaemia in Clinical Diabetes
IA Macdonald, P King |
Hypoglycaemia in Clinical Diabetes | 2013 |
Diabetes, insulin-mediated glucose metabolism and Sertoli/blood-testis barrier function
MG Alves, AD Martins, JE Cavaco, S Socorro, PF Oliveira |
Tissue Barriers | 2013 |
Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society
ER Seaquist, J Anderson, B Childs, P Cryer, S Dagogo-Jack, L Fish, SR Heller, H Rodriguez, J Rosenzweig, R Vigersky |
Diabetes care | 2013 |
Lack of association between residual insulin production and glucagon response to hypoglycemia in youth with short duration of type 1 diabetes
J Sherr, D Xing, KJ Ruedy, RW Beck, C Kollman, B Buckingham, NH White, L Fox, E Tsalikian, S Weinzimer, AM Arbelaez, WV Tamborlane, |
Diabetes care | 2013 |
Amelioration of hypoglycemia via somatostatin receptor type 2 antagonism in recurrently hypoglycemic diabetic rats
JT Yue, MC Riddell, E Burdett, DH Coy, S Efendic, M Vranic |
Diabetes | 2013 |
Restoration of Self-Awareness of Hypoglycemia in Adults With Long-Standing Type 1 Diabetes: Hyperinsulinemic-hypoglycemic clamp substudy results from the HypoCOMPaSS trial
L Leelarathna, SA Little, E Walkinshaw, HK Tan, A Lubina-Solomon, K Kumareswaran, AP Lane, T Chadwick, SM Marshall, J Speight, D Flanagan, SR Heller, JA Shaw, ML Evans |
Diabetes care | 2013 |
Lack of Association Between Residual Insulin Production and Glucagon Response to Hypoglycemia in Youth With Short Duration of Type 1 Diabetes
J Sherr, D Xing, KJ Ruedy, RW Beck, C Kollman, B Buckingham, NH White, L Fox, E Tsalikian, S Weinzimer, AM Arbelaez, WV Tamborlane |
Diabetes care | 2013 |
Treating type 1 diabetes: from strategies for insulin delivery to dual hormonal control
A L McCall, L S Farhy |
Minerva endocrinologica | 2013 |
Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society
ER Seaquist, J Anderson, B Childs, P Cryer, S Dagogo-Jack, L Fish, SR Heller, H Rodriguez, J Rosenzweig, R Vigersky |
The Journal of clinical endocrinology and metabolism | 2013 |
Endocrinology of Physical Activity and Sport
N Constantini, AC Hackney |
2013 | |
Minireview: Glucagon in the Pathogenesis of Hypoglycemia and Hyperglycemia in Diabetes
PE Cryer |
Endocrinology | 2012 |
Impact of Hypoglycemia in Hospitalized Patients
M Carey, L Boucai, J Zonszein |
Current Diabetes Reports | 2012 |
The importance of hypoglycemia in diabetic patients
G Shafiee, M Mohajeri-Tehrani, M Pajouhi, B Larijani |
Journal of Diabetes & Metabolic Disorders | 2012 |
Glucagon secretion and signaling in the development of diabetes
HY Gaisano, PE Macdonald, M Vranic |
Frontiers in physiology | 2012 |
Insight into hypoglycemia in pediatric type 1 diabetes mellitus
KE Lehecka, VS Renukuntla, RA Heptulla |
International Journal of Pediatric Endocrinology | 2012 |
The impact of premorbid diabetic status on the relationship between the three domains of glycemic control and mortality in critically ill patients :
JS Krinsley, G Meyfroidt, G Berghe, M Egi, R Bellomo |
Current Opinion in Clinical Nutrition & Metabolic Care | 2012 |
Recurrent spontaneous hypoglycaemia causes loss of neurogenic and neuroglycopaenic signs in infants with congenital hyperinsulinism : Silent hypoglycaemia in CHI
HT Christesen, K Brusgaard, K Hussain |
Clinical Endocrinology | 2012 |
Nocturnal Hypertension and Special - Period Hypertension in Type 1 Diabetes Mellitus
C Cobuz, M Cobuz |
Romanian Journal of Diabetes Nutrition and Metabolic Diseases | 2012 |
Pharmacokinetic and pharmacodynamic modeling for the effect of sodium-glucose cotransporter inhibitors on blood glucose level and renal glucose excretion in db/db mice
K Yamaguchi, M Kato, K Ozawa, T Kawai, T Yata, Y Aso, M Ishigai, S Ikeda |
Journal of Pharmaceutical Sciences | 2012 |
The dead in bed syndrome revisited: a review of the evidence
PJ Weston |
Diabetes Management | 2012 |
NMDA receptor blockade by memantine does not prevent adaptation to recurrent hypoglycaemia in healthy men
J Klement, I Pais, J Strube, H Lehnert, A Peters, M Hallschmid, J Born |
Diabetes, Obesity and Metabolism | 2012 |
Opioid receptor blockade prevents exercise-associated autonomic failure in humans
S Milman, J Leu, H Shamoon, S Vele, I Gabriely |
Diabetes | 2012 |
Moderate Recurrent Hypoglycemia Markedly Impairs Set-Shifting Ability in a Rodent Model: Cognitive and Neurochemical Effects
V Jahagirdar, J Ramcharitar, VE Cotero, EC McNay |
The Open Diabetes Journal | 2012 |
2. Hypoglycemia Detection
VH Routh, CM Donovan, S Ritter |
2012 | |
Type 1 Diabetes
I Gallen |
2012 | |
Autonomic imbalance: prophet of doom or scope for hope?
AI Vinik, RE Maser, D Ziegler |
Diabetic Medicine | 2011 |
BAD Modulates Counterregulatory Responses to Hypoglycemia and Protective Glucoprivic Feeding
MA Osundiji, ML Godes, ML Evans, NN Danial |
PloS one | 2011 |
Handbook of Clinical Neurology
T Ashizawa, PS Sarkar |
Muscular Dystrophies | 2011 |
Applications of Microdialysis in Pharmaceutical Science
I Smolders, R Clinckers, Y Michotte |
Applications of Microdialysis in Pharmaceutical Science | 2011 |
Modeling the Consistency of Hypoglycemic Symptoms: High Variability in Diabetes
NN Zammitt, G Streftaris, GJ Gibson, IJ Deary, BM Frier |
Diabetes Technology & Therapeutics | 2011 |
Hypoglycemia Risk and Glucose Variability Indices Derived from Routine Self-Monitoring of Blood Glucose Are Related to Laboratory Measures of Insulin Sensitivity and Epinephrine Counterregulation
AN Pitsillides, SM Anderson, B Kovatchev |
Diabetes Technology & Therapeutics | 2011 |
The effect of antecedent hypoglycaemia on β2-adrenergic sensitivity in healthy participants with the Arg16Gly polymorphism of the β2-adrenergic receptor
BJ Schouwenberg, P Smits, CJ Tack, BE de Galan |
Diabetologia | 2011 |
Recurrent hypoglycemia increases oxygen glucose deprivation-induced damage in hippocampal organotypic slices
KR Dave, A Pileggi, AP Raval |
Neuroscience Letters | 2011 |
Hypoglycaemia unawareness
J Elliott, S Heller |
Practical Diabetes International | 2011 |
Hypoglycemia unawareness
SO Bakatselos |
Diabetes Research and Clinical Practice | 2011 |
Brain glycogen content and metabolism in subjects with type 1 diabetes and hypoglycemia unawareness
G Öz, N Tesfaye, A Kumar, DK Deelchand, LE Eberly, ER Seaquist |
Journal of Cerebral Blood Flow & Metabolism | 2011 |
Recent Advances in the Prevention of Hypoglycemia in Type 1 Diabetes
JM Realsen, HP Chase |
Diabetes Technology & Therapeutics | 2011 |
Hypoglycemia in sepsis: Biomarker, mediator, or both?* :
R Bellomo, M Egi |
Critical Care Medicine | 2011 |
Exercise-related hypoglycemia in diabetes mellitus
LM Younk, M Mikeladze, D Tate, SN Davis |
Expert Review of Endocrinology & Metabolism | 2011 |
Williams Textbook of Endocrinology
DW Cooke, SA Divall, S Radovick |
Williams Textbook of Endocrinology | 2011 |
The Effect of Glycemic Variability on Counterregulatory Hormone Responses to Hypoglycemia in Young Children and Adolescents with Type 1 Diabetes
N Alghothani, KM Dungan |
Diabetes Technology & Therapeutics | 2011 |
Optimizing reduction in basal hyperglucagonaemia to repair defective glucagon counterregulation in insulin deficiency
LS Farhy, AL McCall |
Diabetes Obesity and Metabolism | 2011 |
Opioid receptor blockade improves hypoglycemia-associated autonomic failure in type 1 diabetes mellitus
S Vele, S Milman, H Shamoon, I Gabriely |
The Journal of clinical endocrinology and metabolism | 2011 |
Adrenergic Mediation of Hypoglycemia-Associated Autonomic Failure
R Ramanathan, PE Cryer |
Diabetes | 2011 |
Glycemic Control in the ICU
M Egi, S Finfer, R Bellomo |
Chest | 2011 |
BAD Modulates Counterregulatory Responses to Hypoglycemia and Protective Glucoprivic Feeding
MA Osundiji, ML Godes, ML Evans, NN Danial, OS Shirihai |
PloS one | 2011 |
Patient-Specific Modeling in Tomorrow's Medicine
A Gefen |
2011 | |
Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
KA Diggs-Andrews, X Zhang, Z Song, D Daphna-Iken, VH Routh, SJ Fisher |
Diabetes | 2010 |
Mini-review: impact of recurrent hypoglycemia on cognitive and brain function
EC McNay, VE Cotero |
Physiology & Behavior | 2010 |
Hypoglycemia in Type 1 Diabetes Mellitus*
PE Cryer |
Endocrinology and metabolism clinics of North America | 2010 |
Textbook of Diabetes
PM Jones, SJ Persaud |
Textbook of Diabetes | 2010 |
A Practical Manual of Diabetes in Pregnancy
FH Einstein |
A Practical Manual of Diabetes in Pregnancy | 2010 |
Silent Myocardial Infarction and Hypoglycaemia
HK Goh, M Chia, YW Ooi, DE Chew |
The Endocrinologist | 2010 |
Hypoglycemia induced behavioural deficit and decreased GABA receptor, CREB expression in the cerebellum of streptozoticin induced diabetic rats
A Sherin, KT Peeyush, G Naijil, R Chinthu, CS Paulose |
Brain Research Bulletin | 2010 |
Neuroendocrine Responses to Hypoglycemia
N Tesfaye, ER Seaquist |
Annals of the New York Academy of Sciences | 2010 |
Improving Epinephrine Responses in Hypoglycemia Unawareness With Real-Time Continuous Glucose Monitoring in Adolescents With Type 1 Diabetes
TT Ly, J Hewitt, RJ Davey, EM Lim, EA Davis, TW Jones |
Diabetes care | 2010 |
Insulin Reciprocally Regulates Glucagon Secretion in Humans
BA Cooperberg, PE Cryer |
Diabetes | 2010 |
Neuropathy: The Crystal Ball for Cardiovascular Disease?
AI Vinik, RE Maser, D Ziegler |
Diabetes care | 2010 |
Odyssey between Scylla and Charybdis through storms of carbohydrate metabolism and diabetes: a career retrospective
M Vranic |
American journal of physiology. Endocrinology and metabolism | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Evaluation and Management of Adult Hypoglycemic Disorders: An Endocrine Society Clinical Practice Guideline
PE Cryer, L Axelrod, AB Grossman, SR Heller, VM Montori, ER Seaquist, FJ Service |
The Journal of clinical endocrinology and metabolism | 2009 |
Guidelines on the current best practice for the management of type 1 diabetes, sport and exercise
E Perry, IW Gallen |
Practical Diabetes International | 2009 |
Endocrine Emergencies
WR Furman |
ASA Refresher Courses in Anesthesiology | 2009 |
Brain insulin infusion does not augment the counterregulatory response to hypoglycemia or glucoprivation
KK Ishihara, SC Haywood, D Daphna-Iken, EC Puente, SJ Fisher |
Metabolism | 2009 |
What is a NICE-SUGAR for patients in the intensive care unit?
R Bellomo, M Egi |
Mayo Clinic proceedings. Mayo Clinic | 2009 |
What Is a NICE-SUGAR for Patients in the Intensive Care Unit?
R Bellomo, M Egi |
Mayo Clinic Proceedings | 2009 |
Hormones, Brain and Behavior
J Bernal |
Hormones, Brain and Behavior | 2009 |
Attenuated Sympathoadrenal Responses, but Not Severe Hypoglycemia, During Aggressive Glycemic Therapy of Early Type 2 Diabetes
SA Amiel, PE Cryer |
Diabetes | 2009 |
Diabetes-Related Medication-Induced Hypoglycemia
KL Tackett, CS Lancaster, KL Tackett, MK L. |
Journal of Pharmacy Practice | 2009 |
Hypoglycemia-Associated Autonomic Failure Is Prevented by Opioid Receptor Blockade
J Leu, MH Cui, H Shamoon, I Gabriely |
The Journal of clinical endocrinology and metabolism | 2009 |
Blunted counterregulatory hormone responses to hypoglycemia in young children and adolescents with well-controlled type 1 diabetes.
Tsalikian E, Tamborlane W, Xing D, Becker DM, Mauras N, Fiallo-Scharer R, Buckingham B, Weinzimer S, Steffes M, Singh R, Beck R, Ruedy K, Kollman C |
Diabetes care | 2009 |
The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia
NM Sanders, CW Wilkinson, GJ Taborsky, S Al-Noori, W Daumen, A Zavosh, DP Figlewicz |
American journal of physiology. Endocrinology and metabolism | 2008 |
Diabetic neuropathy: mechanisms to management
JL Edwards, AM Vincent, HT Cheng, EL Feldman |
Pharmacology & Therapeutics | 2008 |
Glucagon is absorbed from the rectum but does not hasten recovery from hypoglycaemia in patients with type 1 diabetes
DR Parker, GD Braatvedt, A Bargiota, PG Newrick, S Brown, G Gamble, RJ Corrall |
British Journal of Clinical Pharmacology | 2008 |
Prevention of Hypoglycemia While Achieving Good Glycemic Control in Type 1 Diabetes: The role of insulin analogs
P Rossetti, F Porcellati, GB Bolli, CG Fanelli |
Diabetes care | 2008 |
Increased GABAergic Tone in the Ventromedial Hypothalamus Contributes to Suppression of Counterregulatory Reponses After Antecedent Hypoglycemia
O Chan, H Cheng, R Herzog, D Czyzyk, W Zhu, A Wang, RJ McCrimmon, MR Seashore, RS Sherwin |
Diabetes | 2008 |
The Barrier of Hypoglycemia in Diabetes
PE Cryer |
Diabetes | 2008 |
The effect of long-term insulin treatment with and without antecedent hypoglycemia on neuropeptide and corticosteroid receptor expression in the brains of diabetic rats
KE Inouye, O Chan, JT Yue, M Andrews, Q Li, SG Matthews, M Vranic |
Brain Research Bulletin | 2008 |
Lower levels of circulating IGF-I in Type1 diabetic women with frequent severe hypoglycaemia during pregnancy
LR Nielsen, A Juul, U Pedersen-Bjergaard, B Thorsteinsson, P Damm, ER Mathiesen |
Diabetic Medicine | 2008 |
Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function: Implications for Rigorous Glycemic Control
GK Adler, I Bonyhay, H Failing, E Waring, S Dotson, R Freeman |
Diabetes | 2008 |
Hospitalization and Discharge Education of Emergency Department Patients With Hypoglycemia
AA Ginde, DJ Pallin, CA Camargo |
The Diabetes Educator | 2008 |
Regional Brain Activation during Hypoglycemia in Type 1 Diabetes
G Musen, DC Simonson, NR Bolo, A Driscoll, K Weinger, A Raji, J Théberge, PF Renshaw, AM Jacobson |
The Journal of clinical endocrinology and metabolism | 2008 |
Type 2 Diabetes Mellitus
MN Feinglos, MA Bethel |
2008 | |
Vzaimosvyaz' mezhdu avtonomnoy nevropatiey i bessimptomnymi gipoglikemiyami u patsientov s sakharnym diabetom 1 tipa
OV Svetlova, IV Gur'eva, SN Puzin, OY Vasilenko, EV Orlova |
Diabetes mellitus | 2008 |
Modeling the Effect of Blood Glucose and Physical Exercise on Plasma Adrenaline in People with Type 1 Diabetes
J Kildegaard, TF Christensen, MD Johansen, J Randløv, OK Hejlesen |
Diabetes Technology & Therapeutics | 2007 |
Insulin Therapy and Hypoglycemia in Type 2 Diabetes Mellitus
PE Cryer, I E., MM Karl |
Insulin | 2007 |
Attenuation of counterregulatory responses to recurrent hypoglycemia by active thalamic inhibition: a mechanism for hypoglycemia-associated autonomic failure
AM Arbelaez, WJ Powers, TO Videen, JL Price, PE Cryer |
Diabetes | 2007 |
Type 1 Diabetes in Adults: Principles and Practice
J Cropsey, M Fineman |
Type 1 Diabetes in Adults: Principles and Practice | 2007 |
Attenuation of Amydgala and Frontal Cortical Responses to Low Blood Glucose Concentration in Asymptomatic Hypoglycemia in Type 1 Diabetes: A New Player in Hypoglycemia Unawareness?
JT Dunn, I Cranston, PK Marsden, SA Amiel, LJ Reed |
Diabetes | 2007 |
A Role for the Forebrain in Mediating Time-of-Day Differences in Glucocorticoid Counterregulatory Responses to Hypoglycemia in Rats
LM Gorton, AM Khan, MA Bohland, G Sanchez-Watts, CM Donovan, AG Watts |
Endocrinology | 2007 |
Mechanisms of sympathoadrenal failure and hypoglycemia in diabetes
PE Cryer |
Journal of Clinical Investigation | 2006 |
Antecedent Hindbrain Glucoprivation Does Not Impair the Counterregulatory Response to Hypoglycemia
NM Sanders, GJ Taborsky, CW Wilkinson, W Daumen, DP Figlewicz |
Diabetes | 2006 |
Hypoglycemia
JM Guettier, P Gorden |
Endocrinology & Metabolism Clinics of North America | 2006 |
Physical activity, sport, and pediatric diabetes
MC Riddell, KE Iscoe |
Pediatric Diabetes | 2006 |
Effect of chronic hypoglycaemia on glucose concentration and glycogen content in rat brain: a localized13C NMR study
H Lei, R Gruetter |
Journal of Neurochemistry | 2006 |
Feeding and neuroendocrine responses after recurrent insulin-induced hypoglycemia
NM Sanders, DP Figlewicz, GJ Taborsky, CW Wilkinson, W Daumen, BE Levin |
Physiology & Behavior | 2006 |
From bedside to bench and back again: research issues in animal models of human disease
NC Tkacs, HJ Thompson |
Biological research for nursing | 2006 |
Antecedent hypoglycemia does not alter increased epinephrine-induced lipolysis in type 1 diabetes mellitus
RP Hoffman |
Metabolism | 2006 |
Type 1 Diabetes and Vigorous Exercise: Applications of Exercise Physiology to Patient Management
MC Riddell, BA Perkins |
Canadian Journal of Diabetes | 2006 |
Hormonal, subjective, and neurocognitive responses to brief hypoglycemia in postmenopausal women and age-matched men with type 2 diabetes mellitus
JP Bremer, M Baron, H Peters, KM Oltmanns, W Kern, HL Fehm, J Born, B Schultes |
Metabolism | 2006 |
Antecedent hypercortisolemia is not primarily responsible for generating hypoglycemia-associated autonomic failure
Philip A Goldberg, Ram Weiss, Rory J McCrimmon, Ellen V Hintz, James D Dziura, Robert S Sherwin |
Diabetes | 2006 |
Effects of Insulin Treatment without and with Recurrent Hypoglycemia on Hypoglycemic Counterregulation and Adrenal Catecholamine-Synthesizing Enzymes in Diabetic Rats
KE Inouye, JT Yue, O Chan, T Kim, EM Akirav, E Park, MC Riddell, E Burdett, SG Matthews, M Vranic |
Endocrinology | 2006 |
The effect of pramlintide on hormonal, metabolic or symptomatic responses to insulin-induced hypoglycaemia in patients with type 1 diabetes
SA Amiel, SR Heller, IA Macdonald, SL Schwartz, LJ Klaff, JA Ruggles, C Weyer, OG Kolterman, DG Maggs |
Diabetes, Obesity and Metabolism | 2005 |
Hypoglycaemia and cognitive function
RE Warren, BM Frier |
Diabetes, Obesity and Metabolism | 2005 |
Preserved inhibitory effect of recurrent hypoglycaemia on the male gonadotrophic axis
KM Oltmanns, A Peters, W Kern, HL Fehm, J Born, B Schultes |
Clinical Endocrinology | 2005 |
Epidemiology of Type 2 Diabetes: Focus on Ethnic Minorities
LE Egede, S Dagogo-Jack |
Medical Clinics of North America | 2005 |
Antecedent hypoglycaemia attenuates vascular endothelial growth factor response to subsequent hypoglycaemia in healthy men
V Merl, A Peters, KM Oltmanns, W Kern, C Hubold, HL Fehm, J Born, B Schultes |
Diabetic Medicine | 2005 |
Brain glucose concentrations in healthy humans subjected to recurrent hypoglycemia
AB Criego, I Tkac, A Kumar, W Thomas, R Gruetter, ER Seaquist |
Journal of Neuroscience Research | 2005 |
Hypoglycemia, Hypoglycemia Unawareness and Counterregulation in Children and Adolescents with Type 1 Diabetes Mellitus
Ε Böber, Α Büyükgebiz, Α Verrotti, F Chiarelli |
Journal of Pediatric Endocrinology and Metabolism | 2005 |
Subcutaneous insulin: pharmacokinetic variability and glycemic variability
B Guerci, JP Sauvanet |
Diabetes & Metabolism | 2005 |
International Review of Neurobiology
ZT Bloomgarden |
International review of neurobiology | 2005 |
Differential adaptation of neurocognitive brain functions to recurrent hypoglycemia in healthy men
B Schultes, W Kern, K Oltmanns, A Peters, S Gais, HL Fehm, J Born |
Psychoneuroendocrinology | 2005 |
Brain glucose concentrations in poorly controlled diabetes mellitus as measured by high-field magnetic resonance spectroscopy
ER Seaquist, I Tkac, G Damberg, W Thomas, R Gruetter |
Metabolism | 2005 |
Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis
KE Inouye, O Chan, JT Yue, SG Matthews, M Vranic |
American journal of physiology. Endocrinology and metabolism | 2005 |
Insulin therapy and hypoglycaemia: the size of the problem
CG Fanelli, F Porcellati, S Pampanelli, GB Bolli |
Diabetes/Metabolism Research and Reviews | 2004 |
Hypoglycemia in Type 1 Diabetes Mellitus
S Dagogo-Jack |
Treatments in Endocrinology | 2004 |
Practical Management of Type 1 Diabetes Mellitus in Adolescent Patients
RP Hoffman |
Treatments in Endocrinology | 2004 |
Brain glucose concentrations in patients with type 1 diabetes and hypoglycemia unawareness
AB Criego, I Tkac, A Kumar, W Thomas, R Gruetter, ER Seaquist |
Journal of Neuroscience Research | 2004 |
Hypoglycemia in type 2 diabetes
S Banarer, PE Cryer |
Medical Clinics of North America | 2004 |
Morbidity of hypoglycemia in type 1 diabetes
BM Frier |
Diabetes Research and Clinical Practice | 2004 |
Unstable and Brittle Diabetes
B Ravikumar, R Taylor |
Unstable and Brittle Diabetes | 2004 |
Differences between nighttime and daytime hypoglycemia counterregulation in healthy humans
V Merl, W Kern, A Peters, KM Oltmanns, S Gais, J Born, HL Fehm, B Schultes |
Metabolism | 2004 |
Hypoglycemia and the sympathoadrenal system: neurogenic symptoms are largely the result of sympathetic neural, rather than adrenomedullary, activation
MA DeRosa, PE Cryer |
American journal of physiology. Endocrinology and metabolism | 2004 |
Transplantation of the Pancreas
RW Gruessner, DE Sutherland |
2004 | |
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini |
International Textbook of Diabetes Mellitus | 2003 |
Modulation of hunger by plasma glucose and metformin
B Schultes, KM Oltmanns, W Kern, HL Fehm, J Born, A Peters |
The Journal of clinical endocrinology and metabolism | 2003 |
NOCTURNAL HYPOGLYCEMIA: CLINICAL MANIFESTATIONS AND THERAPEUTIC STRATEGIES TOWARD PREVENTION
KV Allen, BM Frier |
Endocrine Practice | 2003 |
Monocarboxylate transporters contribute to the adaptation of neuronal activity to repeated glucose deprivation in the rat lateral septal nucleus
H Hasuo, T Akasu |
Synapse (New York, N.Y.) | 2003 |
Come prevenire e trattare l’ipoglicemia e la sindrome dell’“hypoglycaemia unawareness” nel diabete mellito di tipo 1
GB Bolli, F Porcellati |
L'Endocrinologo | 2003 |
Pediatric Diabetes
RK Menon, MA Sperling |
Pediatric Diabetes | 2003 |
Role of Hypolipidemic Drug Clofibrate in Altering Iron Regulatory Proteins IRP1 and IRP2 Activities and Hepatic Iron Metabolism in Rats Fed a Low-Iron Diet
HL Huang, NS Shaw |
Toxicology and Applied Pharmacology | 2002 |
Residual insulin secretion is not coupled to a maintained glucagon response to hypoglycaemia in long-term type 1 diabetes
S Sjoberg, B Ahren, J Bolinder |
Journal of Internal Medicine | 2002 |
Maternal hypoglycemia during pregnancy in type 1 diabetes: maternal and fetal consequences
EW Braak, IM Evers, DW Erkelens, GH Visser |
Diabetes/Metabolism Research and Reviews | 2002 |
Does insulin lispro preserve the physiological defences to hypoglycaemia during intensive insulin therapy with a conventional basal bolus regimen?
SR Heller, SA Amiel, ML Evans, MF Kong, IA Macdonald, SR Peacey |
Diabetes, Obesity and Metabolism | 2002 |
Modest contribution of psychosocial variables to hypoglycaemic awareness in Type 1 diabetes
S Broers, KP van Vliet, W Everaerd, SL Cessie, JK Radder |
Journal of Psychosomatic Research | 2002 |
Fisiopatología de la hipoglucemia en la diabetes mellitus
A Rovira |
Endocrinología y Nutrición | 2002 |
Limited impact of vigorous exercise on defenses against hypoglycemia: relevance to hypoglycemia-associated autonomic failure
VP McGregor, JS Greiwe, S Banarer, PE Cryer |
Diabetes | 2002 |
Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response
S Banarer, VP McGregor, PE Cryer |
Diabetes | 2002 |
Hypoglycemia-Associated Autonomic Failure in Advanced Type 2 Diabetes
SA Segel, DS Paramore, PE Cryer |
Diabetes | 2002 |
Diabetes Impairs Hypothalamo-Pituitary-Adrenal (HPA) Responses to Hypoglycemia, and Insulin Treatment Normalizes HPA but not Epinephrine Responses
O Chan, S Chan, K Inouye, K Shum, SG Matthews, M Vranic |
Diabetes | 2002 |
Elevated endogenous cortisol reduces autonomic neuroendocrine and symptom responses to subsequent hypoglycemia
VP McGregor, S Banarer, PE Cryer |
American journal of physiology. Endocrinology and metabolism | 2002 |
Effects of recurrent hyperinsulinemia with and without hypoglycemia on counterregulation in diabetic rats
K Inouye, K Shum, O Chan, J Mathoo, SG Matthews, M Vranic |
American journal of physiology. Endocrinology and metabolism | 2002 |
Symptoms of hypoglycaemia in people with diabetes
V McAulay, IJ Deary, BM Frier |
Diabetic Medicine | 2001 |
Bystanders or Bad Seeds? Many Autoimmune-target Cells May Be Transforming to Cancer and Signalling “Danger” to the Immune System
BP Reines |
Autoimmunity | 2001 |
Sexual dimorphism in counterregulatory responses to hypoglycemia after antecedent exercise
P Galassetti, AR Neill, D Tate, AC Ertl, DH Wasserman, SN Davis |
The Journal of clinical endocrinology and metabolism | 2001 |
Effect of Acute and Antecedent Hypoglycemia on Sympathetic Neural Activity and Catecholamine Responsiveness in Normal Rats
WI Sivitz, JA Herlein, DA Morgan, BD Fink, BG Phillips, WG Haynes |
Diabetes | 2001 |
Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients
RR Russell, D Chyun, S Song, RS Sherwin, WV Tamborlane, FA Lee, MA Pfeifer, F Rife, FJ Wackers, LH Young |
American journal of physiology. Endocrinology and metabolism | 2001 |
Hypoglycemia-associated autonomic failure in diabetes
PE Cryer |
American journal of physiology. Endocrinology and metabolism | 2001 |
Brain glucosensing and the KATP channel
BE Levin, AA Dunn-Meynell, VH Routh |
Nature Neuroscience | 2001 |
Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation
K Shum, K Inouye, O Chan, J Mathoo, D Bilinski, SG Matthews, M Vranic |
American journal of physiology. Endocrinology and metabolism | 2001 |
Klinische Endokrinologie und Stoffwechsel
PP Nawroth, R Ziegler |
2001 | |
Klinische Diabetologie
BO Böhm, KD Palitzsch, C Rosak, GA Spinas |
2001 | |
Physiological responses during hypoglycaemia induced by regular human insulin or a novel human analogue, insulin glargine
S Dagogo-Jack, H Askari, B Morrill, LL Lehner, B Kim, X Sha |
Diabetes, Obesity and Metabolism | 2000 |
Hypoglycemia: A Complication of Diabetes Therapy in Children
DJ Becker, CM Ryan |
Trends in Endocrinology & Metabolism | 2000 |
Changes of glucose transporters in the cerebral adaptation to hypoglycemia
DH Lee, MY Chung, JU Lee, DG Kang, YW Paek |
Diabetes Research and Clinical Practice | 2000 |
HYPOGLYCEMIA
G Herbel, PJ Boyle |
Endocrinology and metabolism clinics of North America | 2000 |
Preserved hypothermic response to hypoglycemia after antecedent hypoglycemia
B Fruehwald-Schultes, W Kern, D Dantz, J Born, HL Fehm, A Peters |
Metabolism | 2000 |
Gender-Related Differences in Counterregulatory Responses to Antecedent Hypoglycemia in Normal Humans1
SN Davis, C Shavers, F Costa |
The Journal of clinical endocrinology and metabolism | 2000 |
Diabetic hypoglycaemia
SR Heller |
Best Practice & Research Clinical Endocrinology & Metabolism | 1999 |
SYMPTOMS OF HYPOGLYCEMIA, THRESHOLDS FOR THEIR OCCURRENCE, AND HYPOGLYCEMIA UNAWARENESS
PE Cryer |
Endocrinology & Metabolism Clinics of North America | 1999 |
Hypoglycemiais the limiting factor in the management of diabetes
PE Cryer |
Diabetes/Metabolism Research and Reviews | 1999 |
Impaired Counterregulation of Glucose in a Patient with Hypothalamic Sarcoidosis
F Féry, L Plat, P de Borne, E Cogan, J Mockel |
New England Journal of Medicine | 1999 |
Protective effect of insulin against hypoglycemia-associated counterregulatory failure
B Fruehwald-Schultes, W Kern, E Deininger, P Wellhoener, W Kerner, J Born, HL Fehm, A Peters |
The Journal of clinical endocrinology and metabolism | 1999 |
Kompendium Diabetologie
PP Nawroth |
1999 | |
Counterregulatory Mechanisms to Insulin-Induced Hypoglycemia in Humans: Relevance to the Problem of Intensive Treatment of IDDM
GB Bolli |
Journal of Pediatric Endocrinology and Metabolism | 1998 |
Diabetes teaching program improves glycemic control and preserves perception of hypoglycemia
A Fritsche |
Diabetes Research and Clinical Practice | 1998 |
Decreased Epinephrine Responses to Hypoglycemia during Sleep
TW Jones, P Porter, RS Sherwin, EA Davis, P O'Leary, F Frazer, G Byrne, S Stick, WV Tamborlane |
New England Journal of Medicine | 1998 |
INTENSIVE TREATMENT OF TYPE 1 DIABETES
IB Hirsch |
Medical Clinics of North America | 1998 |
Prevention of an increase in plasma cortisol during hypoglycemia preserves subsequent counterregulatory responses
SN Davis, C Shavers, B Davis, F Costa |
Journal of Clinical Investigation | 1997 |
Basal serum pancreatic polypeptide is dependent on age and gender in an adult population
MB Damholt, BK Rasmussen, L Hilsted, R Jensen, J Hilsted |
Scandinavian Journal of Clinical & Laboratory Investigation | 1997 |
Strategies for maintaining good glycaemic control without recurrent hypoglycaemia
IA MacDonald |
Proceedings of the Nutrition Society | 1997 |
Urinary excretion of adrenaline and noradrenaline during hypoglycaemic clamp in diabetic and non-diabetic adolescents
M Bjørgaas, T Vik, G Sager, E Sagen, R Jorde |
Scandinavian Journal of Clinical & Laboratory Investigation | 1997 |
IMPLICATIONS AND RESULTS OF THE DIABETES CONTROL AND COMPLICATIONS TRIAL
WV Tamborlane, JA Ahern |
Pediatric Clinics of North America | 1997 |
Resistance to Neuroglycopenia: An Adaptative Response during Intensive Insulin Treatment of Diabetes1
TW Jones, WP Borg, MA Borg, SD Boulware, G McCarthy, D Silver, WV Tamborlane, RS Sherwin |
The Journal of clinical endocrinology and metabolism | 1997 |
Role of cortisol in the pathogenesis of deficient counterregulation after antecedent hypoglycemia in normal humans
SN Davis, C Shavers, F Costa, R Mosqueda-Garcia |
Journal of Clinical Investigation | 1996 |
Time course of the defective α-cell response to hypoglycemia in diabetic BB rats
RJ Jacob, J Dziura, JP Morgen, GI Shulman, RS Sherwin |
Metabolism | 1996 |
Prolactin and β-endorphin responses to hypoglycemia are reduced in well-controlled insulin-dependent diabetes mellitus
BT Kisley, CJ Levy, DC Simonson |
Metabolism | 1996 |
Long-term intensive insulin therapy in IDDM: effects on HbA1c, risk for severe and mild hypoglycaemia, status of counterregulation and awareness of hypoglycaemia
S Pampanelli, C Fanelli, C Lalli, M Ciofetta, PD Sindaco, M Lepore, F Modarelli, AM Rambotti, L Epifano, AD Vincenzo, L Bartocci, B Annibale, P Brunetti, GB Bolli |
Diabetologia | 1996 |
Impact of the Diabetes Control and Complications Trial (DCCT) on Management of Insulin-Dependent Diabetes Mellitus: A Pediatric Perspective
WV Tamborlane, N Attia, R Saif, N Sakati, AA Ashwal |
Annals of Saudi medicine | 1996 |
Glucagon secretory response to hypoglycaemia, adrenaline and carbachol in streptozotocindiabetic rats
B Ahrén, JS Stern, RL Gingerich, DL Curry, PJ Havel |
Acta Physiologica Scandinavica | 1995 |
Surgical removal of insulinoma restores glucose recovery from hypoglycaemia but does not normalize insulin action
SV de Kreutzenberg, A Riccio, M Dorella, A Avogaro, MC Marescotti, A Tiengo, SD Prato |
European Journal of Clinical Investigation | 1995 |
Diabetic autonomic neuropathy
V Spallone, L Uccioli, G Menzinger |
Diabetes / Metabolism Reviews | 1995 |
Reduced β-adrenergic sensitivity in healthy volunteers induced by hypoglycemia
TS Trovik, R Jaeger, R Jorde, G Sager |
Fundamental & Clinical Pharmacology | 1995 |
Brain Glucose Uptake and Unawareness of Hypoglycemia in Patients with Insulin-Dependent Diabetes Mellitus
PJ Boyle, SF Kempers, AM O'Connor, RJ Nagy |
New England Journal of Medicine | 1995 |
A Practical Guide to Intensive Insulin Therapy
PJ Campbell, ME May |
The American Journal of the Medical Sciences | 1995 |
Lack of preservation of higher brain function during hypoglycaemia in patients with intensively-treated IDDM
A Maran, J Lomas, IA Macdonald, SA Amiel |
Diabetologia | 1995 |
Cardiovascular response to exercise in diabetic patients: influence of autonomic neuropathy of different severity
P Bottini, C Tantucci, L Scionti, ML Dottorini, E Puxeddu, G Reboldi, GB Bolli, G Casucci, F Santeusanio, CA Sorbini, P Brunetti |
Diabetologia | 1995 |
Prolonged but partial impairment of the hypoglycaemic physiological response following short-term hypoglycaemia in normal subjects
E George, N Harris, C Bedford, IA Macdonald, CA Hardisty, SR Heller |
Diabetologia | 1995 |
Adaptation in brain glucose uptake following recurrent hypoglycemia
PJ Boyle, RJ Nagy, AM O'Connor, SF Kempers, RA Yeo, C Qualls |
Proceedings of the National Academy of Sciences | 1994 |
Exaggerated epinephrine response to hypoglycemia in a physically fit, well-controlled IDDM subject
SN Davis, RE Goldstein, AD Cherrington, L Price |
Diabetes Research and Clinical Practice | 1994 |
Advances in Pharmacology
B Drenger, Y Ginosar, Y Gozal |
Advances in Pharmacology | 1994 |
Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycaemia, following institution of rational, intensive insulin therapy in IDDM
C Fanelli, S Pampanelli, L Epifano, AM Rambotti, AD Vincenzo, F Modarelli, M Ciofetta, M Lepore, B Annibale, E Torlone, G Perriello, PD Feo, F Santeusanio, P Brunetti, GB Bolli |
Diabetologia | 1994 |
Reversibility of Unawareness of Hypoglycemia in Patients with Insulinomas
A Mitrakou, C Fanelli, T Veneman, G Perriello, S Calderone, D Platanisiotis, A Rambotti, S Raptis, P Brunetti, P Cryer, J Gerich, G Bolli |
New England Journal of Medicine | 1993 |
Diabetic Neuropathy
AI Winegrad |
New England Journal of Medicine | 1972 |