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Citations to this article

Expression of int-2 oncogene in Kaposi's sarcoma lesions.
Y Q Huang, … , B J Poiesz, A E Friedman-Kien
Y Q Huang, … , B J Poiesz, A E Friedman-Kien
Published March 1, 1993
Citation Information: J Clin Invest. 1993;91(3):1191-1197. https://doi.org/10.1172/JCI116279.
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Research Article

Expression of int-2 oncogene in Kaposi's sarcoma lesions.

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Abstract

Fibroblast growth factors (FGFs), such as basic FGF, have been implicated in the growth of Kaposi's sarcoma (KS) cells in vitro. In the evaluation of the expression of the various genes of the different members of the FGF family and their receptors in fresh KS tissue specimens, int-2 was found to be expressed in more than half of the KS tumors examined. Using reverse transcription PCR, the expression of int-2 was detected in 21 of 38 (55.2%) fresh KS biopsy specimens. In contrast, int-2 mRNA transcripts were not found in normal appearing skin from the same patients except in one sample which was obtained from an AIDS patient with disseminated KS lesions. Sequence data confirmed that the amplified sequences were derived from int-2 mRNA with proper splicing. In addition, 12 nucleic acid alterations were identified in eight out of nine KS tumor samples sequenced. Using immunohistochemical methods, int-2 protein was detected in some of the spindle-shaped tumor cells surrounding the abnormal endothelial-lined vascular slits histologically characteristic of KS. Int-2 specific immunostaining was shown to be present in both the nuclei and cytoplasm of these spindle cells but was more pronounced in the nuclei. Neither amplification nor gross rearrangement of the int-2 gene was detected in KS lesions by Southern blot analysis. These results suggest that the expression of int-2 may play a role in the pathogenesis KS by stimulating local angiogenesis and cell proliferation.

Authors

Y Q Huang, J J Li, D Moscatelli, C Basilico, A Nicolaides, W G Zhang, B J Poiesz, A E Friedman-Kien

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Total citations by year

Year: 2023 2022 2020 2016 2014 2012 2011 2010 2009 2008 2006 2002 2000 1999 1998 1997 1996 1995 1994 1988 Total
Citations: 1 1 1 1 1 1 1 1 1 2 1 2 3 1 2 2 3 4 5 1 35
Citation information
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Citations to this article (35)

Title and authors Publication Year
Molecular Signature of Biological Aggressiveness in Clear Cell Sarcoma of the Kidney (CCSK).
Fiore M, Taddia A, Indio V, Bertuccio SN, Messelodi D, Serravalle S, Bandini J, Spreafico F, Perotti D, Collini P, Di Cataldo A, Pasquinelli G, Chiarini F, Fois M, Melchionda F, Pession A, Astolfi A
International journal of molecular sciences 2023
Clonality, Mutation and Kaposi Sarcoma: A Systematic Review.
Indave Ruiz BI, Armon S, Watanabe R, Uttley L, White VA, Lazar AJ, Cree IA
Cancers 2022
Diagnostic Thoracic Pathology
A Weissferdt
2020
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma
B Abere, TF Schulz
Current Opinion in Virology 2016
Manipulation of endothelial cells by KSHV: Implications for angiogenesis and aberrant vascular differentiation
PM Ojala, TF Schulz
Seminars in Cancer Biology 2014
Diagnostic Pathology of Pleuropulmonary Neoplasia
A Weissferdt, CA Moran
2012
Advances in Cancer Research
M Lemaire, S Deleu, ED Bruyne, EV Valckenborgh, E Menu, K Vanderkerken
Advances in Cancer Research Volume 110 2011
Primary vascular tumors of the lungs: a review
A Weissferdt, CA Moran
Annals of Diagnostic Pathology 2010
Methods of Cancer Diagnosis, Therapy, and Prognosis
MA Hayat
2009
Angiogenesis, Kaposi’s sarcoma and Kaposi’s sarcoma-associated herpesvirus
T Kang, FC Ye, SJ Gao, LD Wang
Virologica Sinica 2008
Antiangiogenic Agents in Cancer Therapy
BA Teicher, LM Ellis
2008
Gene Expression and Regulation
J Ma
2006
Fibroblast growth factors in cancer: therapeutic possibilities
M Jeffers, WJ LaRochelle, HS Lichenstein
Expert Opinion on Therapeutic Targets 2002
Angiogenic effects of extracellular human immunodeficiency virus type 1 Tat protein and its role in the pathogenesis of AIDS-associated Kaposi's sarcoma
G Barillari, B Ensoli
Clinical microbiology reviews 2002
Cytokine-mediated growth promotion of Kaposi's sarcoma and primary effusion lymphoma
B Ensoli, M Stürzl, P Monini
Seminars in Cancer Biology 2000
AIDS-Related Cancers and Their Treatment
S Miles
AIDS-Related Cancers and Their Treatment 2000
FGF4 and INT2 Oncogenes Are Amplified and Expressed in Kaposi's Sarcoma
S Kiuru-Kuhlefelt, M Sarlomo-Rikala, ML Larramendy, M Söderlund, K Hedman, M Miettinen, S Knuutila
Modern Pathology 2000
HIV and the New Viruses
S McAdam, F Gotch
HIV and the New Viruses 1999
Advances in Genome Biology
J Perdigão, CE Sunkel
Advances in Genome Biology 1998
Kaposi's sarcoma: a result of the interplay among inflammatory cytokines, angiogenic factors and viral agents
B Ensoli
Cytokine & Growth Factor Reviews 1998
Expression and Mutation of the Tumor Suppressor Gene p53 in AIDS-Associated Kaposi's Sarcoma
JJ Li, YQ Huang, CJ Cockerell, WG Zhang, A Nicolaides, AE Friedman-Kien
The American Journal of Dermatopathology 1997
ADVANCES IN KAPOSI'S SARCOMA
PL Myskowski, R Ahkami
Dermatologic Clinics 1997
Detection of Kaposi's sarcoma-associated herpesvirus-like DNA sequence in angiosarcoma
DP McDonagh, J Liu, MJ Gaffey, LJ Layfield, N Azumi, ST Traweek
The American Journal of Pathology 1996
Localization of human herpes-like virus type 8 in vascular endothelial cells and perivascular spindle-shaped cells of Kaposi's sarcoma lesions by in situ hybridization
JJ Li, YQ Huang, CJ Cockerell, AE Friedman-Kien
The American Journal of Pathology 1996
Kaposi's sarcoma: Advances and perspectives
RA Schwartz
Journal of the American Academy of Dermatology 1996
Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis
F Bussolino, M Arese, G Montrucchio, L Barra, L Primo, R Benelli, F Sanavio, M Aglietta, D Ghigo, MR Rola-Pleszczynski
Journal of Clinical Investigation 1995
Detection of Herpesvirus-Like DNA Sequences in Kaposi's Sarcoma in Patients with and Those without HIV Infection
PS Moore, Y Chang
New England Journal of Medicine 1995
Acquired Immunodeficiency Syndrome-Related Kaposi's Sarcoma
CY Wang, AL Schroeter, WP Su
Mayo Clinic Proceedings 1995
The Genetics of Cancer
BA Ponder, MJ Waring
The Genetics of Cancer 1995
bFGF and its low affinity receptors in the pathogenesis of HIV-associated nephropathy in transgenic mice
PE Ray, LA Bruggeman, BS Weeks, JB Kopp, JL Bryant, JW Owens, AL Notkins, PE Klotman
Kidney International 1994
Rearrangement and expression of MDM2 oncogene in chronic lymphocytic leukemia
YQ Huang, B Raphael, A Buchbinder, JJ Li, WG Zhang, AE Friedman-Kien
American Journal of Hematology 1994
Acanthosis nigricans
RA Schwartz
Journal of the American Academy of Dermatology 1994
HIV-Related Tumors of the Oral Cavity
G Ficarra, LE Eversole
Critical Reviews in Oral Biology & Medicine 1994
Tumor growth and angiogenesis induced by a secreted binding protein for fibroblast growth factors
F Czubayko, RV Smith, HC Chung, A Wellstein
The Journal of biological chemistry 1994
The Molecular and Cellular Biology of Wound Repair
RA Clark, PM Henson
1988

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