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Citations to this article

Lipoprotein-proteoglycan complexes induce continued cholesteryl ester accumulation in foam cells from rabbit atherosclerotic lesions.
P Vijayagopal, … , B Radhakrishnamurthy, G S Berenson
P Vijayagopal, … , B Radhakrishnamurthy, G S Berenson
Published March 1, 1993
Citation Information: J Clin Invest. 1993;91(3):1011-1018. https://doi.org/10.1172/JCI116257.
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Research Article Article has an altmetric score of 3

Lipoprotein-proteoglycan complexes induce continued cholesteryl ester accumulation in foam cells from rabbit atherosclerotic lesions.

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Abstract

We studied the metabolism of lipoprotein-proteoglycan complexes by macrophage-derived foam cells. Foam cells were isolated from atherosclerotic rabbit aortas. ApoB-lipoprotein-proteoglycan complex was isolated from human aorta fibrous plaque lesions and LDL-proteoglycan complex was formed in vitro. Both in vitro and in vivo complexes stimulated cholesteryl ester synthesis in foam cells by a dose-dependent, saturable process that resulted in the intracellular accumulation of cholesteryl ester. Stimulation of cholesteryl ester synthesis was linear with time over a 32-h period. Polyinosinic acid inhibited the stimulation of cholesteryl ester synthesis by the complexes by 32-37%, whereas cytochalasin D only produced a 6-16% inhibition. Foam cells degraded 125I-LDL-proteoglycan complex and 125I-acetyl LDL in a saturable, dose-dependent manner. Excess unlabeled acetyl-LDL inhibited the degradation of 125I-LDL-proteoglycan complex by 52%, while LDL had no effect. Similarly, excess unlabeled complex suppressed the degradation of 125I-acetyl-LDL by 48%. Foam cells degraded 125I-methyl-LDL-proteoglycan complex to the same extent as 125I-LDL-proteoglycan complex. These results show that foam cells from atherosclerotic lesions metabolize lipoprotein-proteoglycan complexes predominantly via receptor-mediated endocytosis and consequently continue to accumulate intracellular cholesteryl ester.

Authors

P Vijayagopal, S R Srinivasan, J H Xu, E R Dalferes Jr, B Radhakrishnamurthy, G S Berenson

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Total citations by year

Year: 2022 2008 2007 2006 2000 1999 1998 1996 1994 Total
Citations: 1 1 1 1 3 2 6 7 3 25
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Citations to this article (25)

Title and authors Publication Year
Smooth Muscle Cell—Macrophage Interactions Leading to Foam Cell Formation in Atherosclerosis: Location, Location, Location
Xiang P, Blanchard V, Francis GA
Frontiers in physiology 2022
Hyperelongated biglycan: the surreptitious initiator of atherosclerosis
PJ Little, N Osman, KD OʼBrien
Current Opinion in Lipidology 2008
Fatty acid-induced atherogenic changes in extracellular matrix proteoglycans
M Rodriguéz-Lee, G Bondjers, G Camejo
Current Opinion in Lipidology 2007
Hyaluronan forms complexes with low density lipoprotein while also inducing foam cell infiltration in the dermis
M Seike, M Ikeda, M Matsumoto, R Hamada, M Takeya, H Kodama
Journal of Dermatological Science 2006
Macrophage-released proteoglycans enhance LDL aggregation: studies in aorta from apolipoprotein E-deficient mice
I Maor, T Hayek, M Hirsh, TC Iancu, M Aviram
Atherosclerosis 2000
Metabolic evidence for sequestration of low-density lipoprotein in abdominal aorta of normal rabbits
DC Schwenke
American journal of physiology. Heart and circulatory physiology 2000
Lipoprotein lipase-mediated interactions of small proteoglycans and low-density lipoproteins
E Schönherr, B Zhao, H Hausser, M Müller, C Langer, WD Wagner, IJ Goldberg, H Kresse
European Journal of Cell Biology 2000
Vascular biology, atherosclerosis, and implications for cardiac care
GS Berenson, SR Srinivasan, B Radhakrishnamurthy
Current Atherosclerosis Reports 1999
Serum Amyloid A, an Acute-Phase Protein, Modulates Proteoglycan Synthesis in Cultured Murine Peritoneal Macrophages
R Elliott-Bryant, JE Silbert, G Sugumaran
Biochemical and Biophysical Research Communications 1999
Enhanced macrophage uptake of lipoprotein(a) after Ca2+-induced aggregate-formation
S Tanaka, A Yashiro, H Tasaki, Y Nakashima
Lipids 1998
Association of apo B lipoproteins with arterial proteoglycans: Pathological significance and molecular basis
G Camejo, E Hurt-Camejo, O Wiklund, G Bondjers
Atherosclerosis 1998
Distribution of Hyaluronan and Dermatan/Chondroitin Sulfate Proteoglycans in Human Aortic Dissection
PS Gutierrez, MM Reis, ML Higuchi, VD Aiello, NA Stolf, EA Lopes
Connective Tissue Research 1998
Proteoglycans in macrophages: characterization and possible role in the cellular uptake of lipoproteins
B Halvorsen, UK Aas, MA Kulseth, CA Drevon, EN Christiansen, SO Kolset
Biochemical Journal 1998
Antioxidants and atherogenesis
DC Schwenke
The Journal of Nutritional Biochemistry 1998
Comparison of Apolipoprotein and Proteoglycan Deposits in Human Coronary Atherosclerotic Plaques: Colocalization of Biglycan With Apolipoproteins
KD OBrien, KL Olin, CE Alpers, W Chiu, M Ferguson, K Hudkins, TN Wight, A Chait
Circulation 1998
The heparin-bound fraction of human lipoprotein-deficient serum inhibits endocytic uptake of oxidized low density lipoprotein by macrophages
Y Suginohara, A Miyazaki, H Hakamata, YI Sakamoto, T Ohta, I Matsuda, S Horiuchi
Atherosclerosis 1996
Lipoprotein lipase stimulates the binding and uptake of moderately oxidized low-density lipoprotein by J774 macrophages
WL Hendriks, H der Boom, LC van Vark, LM Havekes
Biochemical Journal 1996
Antioxidants, dietary fat saturation, lipoprotein oxidation and atherogenesis
DC Schwenke
Nutrition 1996
Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis
IJ Goldberg
Journal of lipid research 1996
Development of the Lipid-Rich Core in Human Atherosclerosis
JR Guyton, KF Klemp
Arteriosclerosis, thrombosis, and vascular biology 1996
Apolipoproteins B, (a), and E Accumulate in the Morphologically Early Lesion of ‘Degenerative’ Valvular Aortic Stenosis
KD OBrien, DD Reichenbach, SM Marcovina, J Kuusisto, CE Alpers, CM Otto
Arteriosclerosis, thrombosis, and vascular biology 1996
Macrophages Stimulate Cholesteryl Ester Accumulation in Cocultured Smooth Muscle Cells Incubated With Lipoprotein-Proteoglycan Complex
P Vijayagopal, DL Glancy
Arteriosclerosis, thrombosis, and vascular biology 1996
Regulation of the metabolism of lipoprotein-proteoglycan complexes in human monocyte-derived macrophages
P Vijayagopal
Biochemical Journal 1994
The biology of the artery wall in atherogenesis
KD O'Brien, A Chait
Medical Clinics of North America 1994
Oxidation of heparin-isolated LDL by hemin. The effect of serum components
WH Sutherland
Arteriosclerosis Thrombosis and Vascular Biology 1994

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