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Citations to this article

Effects of oleate-rich and linoleate-rich diets on the susceptibility of low density lipoprotein to oxidative modification in mildly hypercholesterolemic subjects.
P Reaven, … , D Steinberg, J L Witztum
P Reaven, … , D Steinberg, J L Witztum
Published February 1, 1993
Citation Information: J Clin Invest. 1993;91(2):668-676. https://doi.org/10.1172/JCI116247.
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Effects of oleate-rich and linoleate-rich diets on the susceptibility of low density lipoprotein to oxidative modification in mildly hypercholesterolemic subjects.

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Abstract

We report the results of feeding oleate- or linoleate-enriched diets for 8 wk to mildly hypercholesterolemic subjects and the resulting alterations in composition and functional properties of their plasma LDL and HDL. LDL isolated from subjects on oleate-enriched diets was less susceptible to copper-mediated oxidation, as measured by conjugated diene and lipid peroxide formation, and less susceptible to LDL-protein modification, as evidenced by reduced LDL macrophage degradation after copper- or endothelial cell-induced oxidation. For all subjects, the percentage of 18:2 in LDL correlated strongly with the extent of conjugated diene formation (r = 0.89, P < 0.01) and macrophage degradation (r = 0.71, P < 0.01). Oxidation of LDL led to initial rapid depletion of unsaturated fatty acids in phospholipids followed by extensive loss of unsaturated fatty acids in cholesteryl esters and triglycerides. Changes in HDL fatty acid composition also occurred. However, HDL from both dietary groups retained its ability to inhibit oxidative modification of LDL. This study demonstrates that alterations in dietary fatty acid composition can effectively alter the fatty acid distribution of LDL and HDL in hypercholesterolemic subjects and that susceptibility to LDL oxidation is altered by these changes. Substitution of monounsaturated (rather than polyunsaturated) fatty acids for saturated fatty acids in the diet might be preferable for the prevention of atherosclerosis.

Authors

P Reaven, S Parthasarathy, B J Grasse, E Miller, D Steinberg, J L Witztum

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Dietary Lipids in the Aetiology of Alzheimer???s Disease: Implications for Therapy
JL Cooper
Drugs & Aging 2003
Protective effect of dietary monounsaturated fat on arteriosclerosis: beyond cholesterol
F Pérez-Jiménez, J López-Miranda, P Mata
Atherosclerosis 2002
Comparison of LDL fatty acid and carotenoid concentrations and oxidative resistance of LDL in volunteers from countries with different rates of cardiovascular disease
AJ Wright, S Southon, M Chopra, A Meyer-Wenger, U Moser, F Granado, B Olmedilla, B Corridan, I Hinninger, AM Roussel, H Berg, DI Thurnham
British Journal of Nutrition 2002
Effect of meals rich in heated olive and safflower oils on oxidation of postprandial serum in healthy men
WH Sutherland, SA de Jong, RJ Walker, MJ Williams, CM Skeaff, A Duncan, M Harper
Atherosclerosis 2002
Effect of dietary monounsaturated/saturated fatty acid ratio on fatty acid composition and oxidative stability of tissues in broilers
HF Hsieh, SH Chiang, MY Lu
Animal Feed Science and Technology 2002
Enfermedad cardiovascular y grasas: “amigo o villano”
MA Rubio
Endocrinología y Nutrición 2002
Influence of dietary fat saturation on lipid peroxidation of serum and low density lipoprotein in rats
YF Lu, S Lu
Nutrition Research 2002
Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells
M Toborek, YW Lee, R Garrido, S Kaiser, B Hennig
The American journal of clinical nutrition 2002
Fatty acid composition of low-density lipoprotein in renal transplant recipients treated with cyclosporine
F Cofan, D Zambon, JC Laguna, E Ros, E Casals, M Cofan, JM Campistol, F Oppenheimer
Transplantation Proceedings 2002
Effects of oleic-rich and omega-3-rich diets on serum lipid pattern and lipid oxidation in mildly hypercholesterolemic patients
C PUIGGRÓS, P CHACÓN, L Armadans, J CLAPÉS, M PLANAS
Clinical Nutrition 2002
Effect of Alcohol on Lipids and Lipoproteins in Relation to Atherosclerosis
ML Hannuksela, MK Liisanantti, MJ Savolainen
Critical Reviews in Clinical Laboratory Sciences 2002
Eicosapentaenoic Acid Improves Endothelial Function in Hypertriglyceridemic Subjects Despite Increased Lipid Oxidizability
T Okumura, Y Fujioka, S Morimoto, S Tsuboi, M Masai, T Tsujino, M Ohyanagi, T Iwasaki
The American Journal of the Medical Sciences 2002
Decreased aortic early atherosclerosis in hypercholesterolemic hamsters fed oleic acid-rich TriSun oil compared to linoleic acid-rich sunflower oil
RJ Nicolosi, TA Wilson, G Handelman, T Foxall, JF Keaney, JA Vita
The Journal of Nutritional Biochemistry 2002
Effects of dietary fatty acids on the composition and oxidizability of low-density lipoprotein
M Kratz, P Cullen, F Kannenberg, A Kassner, M Fobker, PM Abuja, G Assmann, U Wahrburg
European Journal of Clinical Nutrition 2002
Dietary Modifications and Gene Polymorphisms Alter Serum Paraoxonase Activity in Healthy Women
M Rantala, ML Silaste, A Tuominen, J Kaikkonen, JT Salonen, G Alfthan, A Aro, YA Kesäniemi
The Journal of nutrition 2002
The Scientific Evidence for a Beneficial Health Relationship Between Walnuts and Coronary Heart Disease
EB Feldman
The Journal of nutrition 2002
Dose Response of Almonds on Coronary Heart Disease Risk Factors: Blood Lipids, Oxidized Low-Density Lipoproteins, Lipoprotein(a), Homocysteine, and Pulmonary Nitric Oxide: A Randomized, Controlled, Crossover Trial
DJ Jenkins, CW Kendall, A Marchie, TL Parker, PW Connelly, W Qian, JS Haight, D Faulkner, E Vidgen, KG Lapsley, GA Spiller
Circulation 2002
Lipid Metabolism in Pregnancy and its Consequences in the Fetus and Newborn
E Herrera
Endocrine 2002
Extra-virgin olive oil-enriched diets reduce indomethacin-induced gastric oxidative damage in rats
C Alarcón de la Lastra, M D Barranco, M J Martín, J Herrerías, V Motilva
Digestive Diseases and Sciences 2002
Habitual fish intake is associated with decreased LDL susceptibility to ex vivo oxidation
JC de Gordoa, M de Renobales, A del Cerro, EF de Labastida, P Amiano, M Dorronsoro
Lipids 2002
Effects of a high polyunsaturated fat diet and vitamin E supplementation on high-density lipoprotein oxidation in humans
JW Schnell, RA Anderson, JE Stegner, SP Schindler, RB Weinberg
Atherosclerosis 2001
Interaction between the Gln–Arg 192 variants of the paraoxonase gene and oleic acid intake as a determinant of high-density lipoprotein cholesterol and paraoxonase activity
M Tomás, M Sentı́, R Elosua, J Vila, J Sala, R Masià, J Marrugat
European Journal of Pharmacology 2001
Susceptibility of LDL to oxidative modification in healthy volunteers supplemented with low doses of n-3 polyunsaturated fatty acids
S Higgins, YL Carroll, SN McCarthy, BM Corridan, HM Roche, JM Wallace, NM O'Brien, PA Morrissey
British Journal of Nutrition 2001
The Cochrane Database of Systematic Reviews: Reviews
VJ Poustie, P Rutherford, VJ Poustie
The Cochrane Database of Systematic Reviews: Reviews 2001
Nutrition in the Prevention and Treatment of Disease
JM Ordovas
Nutrition in the Prevention and Treatment of Disease 2001
Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages
KL Carpenter, IF Dennis, IR Challis, DP Osborn, CH Macphee, DS Leake, MJ Arends, MJ Mitchinson
FEBS Letters 2001
High-Energy Diets, Fatty Acids and Endothelial Cell Function: Implications for Atherosclerosis
B Hennig, M Toborek, CJ McClain
Journal of the American College of Nutrition 2001
Nutrition and endothelial cell function: implications in atherosclerosis
B Hennig, M Toborek
Nutrition Research 2001
Linoleic acid induces MCP-1 gene expression in human microvascular endothelial cells through an oxidative mechanism
YW Lee, HJ Park, B Hennig, M Toborek
The Journal of Nutritional Biochemistry 2001
Low Fat and High Monounsaturated Fat Diets Decrease Human Low Density Lipoprotein Oxidative Susceptibility In Vitro
RL Hargrove, TD Etherton, TA Pearson, EH Harrison, PM Kris-Etherton
The Journal of nutrition 2001
A diet containing rapeseed oil-based fats does not increase lipid peroxidation in humans when compared to a diet rich in saturated fatty acids
E Södergren, IB Gustafsson, S Basu, J Nourooz-Zadeh, C Nälsén, A Turpeinen, L Berglund, B Vessby
European Journal of Clinical Nutrition 2001
The effect of meals rich in thermally stressed olive and safflower oils on postprandial serum paraoxonase activity in patients with diabetes
AJ Wallace, WH Sutherland, JI Mann, SM Williams
European Journal of Clinical Nutrition 2001
Effects of dietary virgin olive oil phenols on low density lipoprotein oxidation in hyperlipidemic patients
R Masella, C Giovannini, R Varì, RD Benedetto, E Coni, R Volpe, N Fraone, A Bucci
Lipids 2001
Oxidized low density lipoprotein reduces monocyte CCR2 expression through pathways that involve activation of peroxisome proliferator-activated receptor gamma (PPARgamma)
Ki Hoon Han, Mi Kyung Chang, Agnes Boullier, Simone R. Green, Andrew Li, Christopher K. Glass, Oswald Quehenberger
Journal of Clinical Investigation 2000
The effects of N-6 polyunsaturated fatty acid supplementation on the lipid composition and atherogenesis in mouse models of atherosclerosis
J George, M Mulkins, S Casey, R Schatzman, E Sigal, D Harats
Atherosclerosis 2000
The effect of concentrated n-3 fatty acids versus gemfibrozil on plasma lipoproteins, low density lipoprotein heterogeneity and oxidizability in patients with hypertrygliceridemia
AF Stalenhoef, J Graaf, ME Wittekoek, SJ Bredie, PN Demacker, JJ Kastelein
Atherosclerosis 2000
Therapeutic potential of vitamin E in heart disease
D Bunout
Expert Opinion on Investigational Drugs 2000
Dietary cholesterol increases the susceptibility of low density lipoprotein to oxidative modification
US Schwab, LM Ausman, S Vogel, Z Li, CJ Lammi-Keefe, BR Goldin, JM Ordovas, EJ Schaefer, AH Lichtenstein
Atherosclerosis 2000
Dilinoleoylphosphatidylcholine protects human low density lipoproteins against oxidation
KP Navder, E Baraona, CS Lieber
Atherosclerosis 2000
Current Concepts in Optimum Nutrition for Cardiovascular Disease
R Platt
Preventive Cardiology 2000
Effects of supplementation with folic acid and antioxidant vitamins on homocysteine levels and LDL oxidation in coronary patients
D Bunout, A Garrido, M Suazo, R Kauffman, P Venegas, P la Maza, M Petermann, S Hirsch
Nutrition 2000
Consumption of tomato products with olive oil but not sunflower oil increases the antioxidant activity of plasma
A Lee, DI Thurnham, M Chopra
Free radical biology & medicine 2000
Antithrombotic Potential of Olive Oil Administration in Rabbits with Elevated Cholesterol
JP de la Cruz, MA Villalobos, JA Carmona, M Martı́n-Romero, JM Smith-Agreda, FS de la Cuesta
Thrombosis Research 2000
Fenómenos oxidativos en la fisiopatología vascular
JM Gui, AM Amenós
Hipertensión y Riesgo Vascular 2000
Low density lipoproteins develop resistance to oxidative modification due to inhibition of cholesteryl ester transfer protein by a monoclonal antibody
M Sugano, S Sawada, K Tsuchida, N Makino, M Kamada
Journal of lipid research 2000
Conjugated linoleic acid reduces early aortic atherosclerosis greater than linoleic acid in hypercholesterolemic hamsters
TA Wilson, RJ Nicolosi, M Chrysam, D Kritchevsky
Nutrition Research 2000
Measurement of free cholesterol, cholesteryl esters and cholesteryl linoleate hydroperoxide in copper-oxidised low density lipoprotein in healthy volunteers supplemented with a low dose of n-3 polyunsaturated fatty acids
S Higgins, SN McCarthy, BM Corridan, HM Roche, JM Wallace, NM O'Brien, PA Morrissey
Nutrition Research 2000
Lipid peroxidation and glutathione system in hyperlipemic rabbits: influence of olive oil administration
JP de la Cruz, L Quintero, MA Villalobos, FS de la Cuesta
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2000
Lowering Dietary Saturated Fat and Total Fat Reduces the Oxidative Susceptibility of LDL in Healthy Men and Women
S Yu-Poth, TD Etherton, CC Reddy, TA Pearson, R Reed, G Zhao, S Jonnalagadda, Y Wan, PM Kris-Etherton
The Journal of nutrition 2000
LDL of Taiwanese Vegetarians Are Less Oxidizable than Those of Omnivores
SC Lu, WH Wu, CA Lee, HF Chou, HR Lee, PC Huang
The Journal of nutrition 2000
Safety considerations of polyunsaturated fatty acids
J Eritsland
The American journal of clinical nutrition 2000
Normal Oxidative Stress and Enhanced Lipoprotein Resistance to In Vitro Oxidation in Hypertriglyceridemia: Effects of Bezafibrate Therapy
FH de Man, IJ Jonkers, E Schwedhelm, AH Smelt, W Onkenhout, W van Duyvenvoorde, R Buytenhek, JA Leuven, R Troost, A van der Laarse, HM Princen
Arteriosclerosis, thrombosis, and vascular biology 2000
Oxidative Stress and Vascular Disease
JF Keaney
2000
Handbook of Olive Oil
J Harwood, R Aparicio
2000
Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid–protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins
S Hörkkö, DA Bird, E Miller, H Itabe, N Leitinger, G Subbanagounder, JA Berliner, P Friedman, EA Dennis, LK Curtiss, W Palinski, JL Witztum
Journal of Clinical Investigation 1999
A simple and sensitive method in using the ratios of cholesteryl ester molecular species as indexes of oxidative stress in plasma and lipoprotein fractions
DM Lee
Atherosclerosis 1999
Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids
L Frémont, L Belguendouz, S Delpal
Life Sciences 1999
A pilot study of garlic consumption shows no significant effect on markers of oxidation or sub-fraction composition of low-density lipoprotein including lipoprotein(a) after allowance for non-compliance and the placebo effect
DJ Byrne, HA Neil, DT Vallance, AF Winder
Clinica Chimica Acta 1999
Antioxidants and lipoprotein metabolism
M Chopra, DI Thurnham
Proceedings of the Nutrition Society 1999
Low-density lipoprotein (LDL) oxidizability before and after LDL apheresis
MG Donner, KG Parhofer, WO Richter, P Schwandt
Metabolism 1999
Establishing the Significance and Optimal Intake of Dietary Antioxidants: The Biomarker Concept
B Halliwell
Nutrition Reviews 1999
Effects of dietary fatty acids and vitamin E levels in HL-60 cell proliferation
C Colome, R Alonso, P Mata, L Badimon
European Journal of Clinical Investigation 1999
Effects of Fish Oil Supplementation on Platelet Survival and ex Vivo Platelet Function in Hypercholesterolemic Patients
C Pirich, A Gaszo, S Granegger, H Sinzinger
Thrombosis Research 1999
Lipid peroxidation and atherosclerosis in type II diabetes
WA Oranje, BH Wolffenbuttel
Journal of Laboratory and Clinical Medicine 1999
Copper Oxidation ofin VitroDioleolylphosphatidylcholine-Enriched High-Density Lipoproteins: Physicochemical Features and Cholesterol Effluxing Capacity
P Thérond, D Bonnefont-Rousselot, C Laureaux, MP Vasson, C Motta, A Legrand, J Delattre
Archives of Biochemistry and Biophysics 1999
Fatty acid composition in low-density lipoproteins from renal transplant recipients
F Cofan, D Zambon, C Rodriguez, JC Laguna, M Vazquez, E Casals, J Torregrosa, E Ros, F Oppenheimer
Transplantation Proceedings 1999
AHA Science Advisory: Monounsaturated Fatty Acids and Risk of Cardiovascular Disease
PM Kris-Etherton
The Journal of nutrition 1999
High–monounsaturated fatty acid diets lower both plasma cholesterol and triacylglycerol concentrations
PM Kris-Etherton, TA Pearson, Y Wan, RL Hargrove, K Moriarty, V Fishell, TD Etherton
The American journal of clinical nutrition 1999
Monounsaturated Fatty Acids and Risk of Cardiovascular Disease
PM Kris-Etherton
Circulation 1999
All ApoB-Containing Lipoproteins Induce Monocyte Chemotaxis and Adhesion When Minimally Modified: Modulation of Lipoprotein Bioactivity by Platelet-Activating Factor Acetylhydrolase
C Lee, F Sigari, T Segrado, S Hörkkö, S Hama, PV Subbaiah, M Miwa, M Navab, JL Witztum, PD Reaven
Arteriosclerosis, thrombosis, and vascular biology 1999
LDL Isolated From Greek Subjects on a Typical Diet or From American Subjects on an Oleate-Supplemented Diet Induces Less Monocyte Chemotaxis and Adhesion When Exposed to Oxidative Stress
S Tsimikas, A Philis-Tsimikas, S Alexopoulos, F Sigari, C Lee, PD Reaven
Arteriosclerosis, thrombosis, and vascular biology 1999
Autoantibodies Against Oxidatively Modified LDL Do Not Constitute a Risk Factor for Stroke: A Nested Case-Control Study
E Ahmed, J Trifunovic, B Stegmayr, G Hallmans, AK Lefvert
Stroke; a journal of cerebral circulation 1999
Atherosclerosis and conjugated linoleic acid
LL Rudel
British Journal of Nutrition 1999
Oxidants and antioxidants in atherogenesis: an appraisal
S Parthasarathy, N Santanam, S Ramachandran, O Meilhac
Journal of lipid research 1999
Oxidation of LDL in baboons is increased by alcohol and attenuated by polyenylphosphatidylcholine
KP Navder, E Baraona, MA Leo, CS Lieber
Journal of lipid research 1999
A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans.
Turpeinen AM, Basu S, Mutanen M
Lipids 1999
Lipoprotein and cholesterol metabolism in diet-induced coronary artery atherosclerosis in primates
LL Rudel, JS Parks, CC Hedrick, M Thomas, K Williford
Progress in Lipid Research 1998
Is oxidized low???density lipoprotein present in vivo?
NA Ylä-Herttuala
Current Opinion in Lipidology 1998
Polyunsaturated fatty acid enrichment enhances endothelial cell-induced low-density-lipoprotein peroxidation
C Mazière, F Dantin, MA Conte, J Degonville, D Ali, F Dubois, JC Mazière
Biochemical Journal 1998
Beneficial effect of gemfibrozil on the chemical composition and oxidative susceptibility of low density lipoprotein: a randomized, double-blind, placebo-controlled study
H Yoshida, T Ishikawa, M Ayaori, H Shige, T Ito, M Suzukawa, H Nakamura
Atherosclerosis 1998
Cholesteryl esterase-treated LDL augments oxidized LDL-mediated cholesteryl ester deposition in mouse peritoneal macrophages
H Yu, RL Gutman, BH Ryu, P Greenspan
Atherosclerosis 1998
Low-fat, monounsaturate-rich diets reduce susceptibility of low density lipoproteins to peroxidation ex vivo
DJ O'Byrne, SF O'Keefe, RB Shireman
Lipids 1998
Influence of long-chain polyunsaturated fatty acids on oxidation of low density lipoprotein
RC Wander, SH Du, DR Thomas
Prostaglandins, Leukotrienes and Essential Fatty Acids 1998
A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans
AM Turpeinen, S Basu, M Mutanen
Prostaglandins, Leukotrienes and Essential Fatty Acids 1998
Implications of Lag Time Concept in the Oxidation of LDL
S Parthasarathy, N Augé, N Santanam
Free Radical Research 1998
Antioxidants and atherogenesis
DC Schwenke
The Journal of Nutritional Biochemistry 1998
Varying Dietary Fat Type of Reduced-Fat Diets Has Little Effect on the Susceptibility of LDL to Oxidative Modification in Moderately Hypercholesterolemic Subjects
US Schwab, S Vogel, CJ Lammi-Keefe, JM Ordovas, EJ Schaefer, Z Li, LM Ausman, L Gualtieri, BR Goldin, HC Furr, AH Lichtenstein
The Journal of nutrition 1998
Dietary Flavonoids Reduce Lipid Peroxidation in Rats Fed Polyunsaturated or Monounsaturated Fat Diets
L Frémont, MT Gozzélino, MP Franchi, A Linard
The Journal of nutrition 1998
Liposomes enriched in oleic acid are less susceptible to oxidation and have less proinflammatory activity when exposed to oxidizing conditions
C Lee, J Barnett, PD Reaven
Journal of lipid research 1998
Effects of specific fatty acids (8:0,14:0, cis-18:1, trans-18:1) on plasma lipoproteins, early atherogenic potential, and LDL oxidative properties in the hamster
RJ Nicolosi, TA Wilson, EJ Rogers, D Kritchevsky
Journal of lipid research 1998
Hepatic origin of cholesteryl oleate in coronary artery atherosclerosis in African green monkeys. Enrichment by dietary monounsaturated fat
LL Rudel, J Haines, JK Sawyer, R Shah, MS Wilson, TP Carr
Journal of Clinical Investigation 1997
Endothelial cell monolayer dysfunction caused by oxidized low density lipoprotein: attenuation by oleic acid
RJ Karman, JG Garcia, CM Hart
Prostaglandins, Leukotrienes and Essential Fatty Acids 1997
Glycation, oxidation, and lipoxidation in the development of diabetic complications
AL Kennedy, TJ Lyons
Metabolism 1997
Effect of low density lipoprotein fatty acid composition on copper-induced peroxidation: 1H-nuclear magnetic resonance analysis
G Corso, E Trivellone, A Motta, A Postiglione, FP Mancinia, V Carbone, C Napoli
Clinica Chimica Acta 1997
Diet and premenopausal bilateral breast cancer: A case-control study
JS Witte, G Ursin, J Siemiatycki, WD Thompson, A Paganini-Hill, RW Haile
Breast Cancer Research and Treatment 1997
Exogenous fatty acids modulate the functional and cytotoxic responses of cultured pulmonary artery endothelial cells to oxidant stress
RJ Karman, MP Gupta, JG Garcia, CM Hart
Journal of Laboratory and Clinical Medicine 1997
Glycation, oxidation, and lipoxidation in the development of the complications of diabetes: a carbonyl stress hypothesis
Timothy J. Lyons, Alicia J. Jenkins
Diabetes reviews (Alexandria, Va.) 1997
Seasonal Variation in Low Density Lipoprotein Oxidation and Antioxidant Status
LP van de Vijver, WV Duyvenvoorde, R Buyienhek, AV der Laarse, AF Kardinaal, HV Berg, HM Princen
Free Radical Research 1997
Oxidation of low density lipoprotein in hemodialysis patients: effect of dialysis and comparison with matched controls
J Westhuyzen, D Saltissi, H Healy
Atherosclerosis 1997
Endogenous Synthesis Cannot Compensate for Absence of Dietary Oleic Acid in Rats
JM Bourre, OL Dumont, ME Clément, GA Durand
The Journal of nutrition 1997
Effect of 17β-Estradiol on Plasma Lipids and LDL Oxidation in Postmenopausal Women With Type II Diabetes Mellitus
HE Brussaard, JA Leuven, C Kluft, HM Krans, W van Duyvenvoorde, R Buytenhek, A van der Laarse, HM Princen
Arteriosclerosis, thrombosis, and vascular biology 1997
Monounsaturated and Polyunsaturated n-6 Fatty Acid–Enriched Diets Modify LDL Oxidation and Decrease Human Coronary Smooth Muscle Cell DNA Synthesis
P Mata, O Varela, R Alonso, C Lahoz, M de Oya, L Badimon
Arteriosclerosis, thrombosis, and vascular biology 1997
Peroxidation of LDL From Combined-Hyperlipidemic Male Smokers Supplied With ¯-3 Fatty Acids and Antioxidants
IR Brude, CA Drevon, I Hjermann, I Seljeflot, S Lund-Katz, K Saarem, B Sandstad, K Solvoll, B Halvorsen, H Arnesen, MS Nenseter
Arteriosclerosis, thrombosis, and vascular biology 1997
Handbook of Essential Fatty Acid Biology
S Yehuda, DI Mostofsky
1997
Extent of antioxidant protection of plasma LDL is not a predictor of the antiatherogenic effect of antioxidants
J Fruebis, DA Bird, J Pattison, W Palinski
Journal of lipid research 1997
Cholesterol deposition in macrophages: foam cell formation mediated by cholesterol-enriched oxidized low density lipoprotein
P Greenspan, H Yu, F Mao, RL Gutman
Journal of lipid research 1997
RRR-alpha-tocopherol can be substituted for by Trolox in determination of kinetic parameters of LDL oxidizability by copper
AR Bergmann, P Ramos, H Esterbauer, BM Winklhofer-Roob
Journal of lipid research 1997
Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein
S Hörkkö, E Miller, E Dudl, P Reaven, LK Curtiss, NJ Zvaifler, R Terkeltaub, SS Pierangeli, DW Branch, W Palinski, JL Witztum
Journal of Clinical Investigation 1996
Modification of Lipoproteins in Diabetes
MF Lopes-Virella, RL Klein, G Virella
Diabetes/Metabolism Reviews 1996
Enhanced capacity of n-3 fatty acid-enriched macrophages to oxidize low density lipoprotein mechanisms and effects of antioxidant vitamins
M Suzukawa, M Abbey, P Clifton, PJ Nestel
Atherosclerosis 1996
Iron-ascorbate-phospholipid mediated modification of low density lipoprotein
P Greenspan
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1996
Effect of olive and sunflower oils on low density lipoprotein level, composition, size, oxidation and interaction with arterial proteoglycans
R Carmena, JF Ascaso, G Camejo, G Varela, E Hurt-Camejo, JM Ordovas, J Martinez-Valls, M Bergstöm, B Wallin
Atherosclerosis 1996
Fall in total cholesterol concentration over five years in association with changes in fatty acid composition of cooking oil in Mauritius: cross sectional survey
U Uusitalo, EJ Feskens, J Tuomilehto, G Dowse, U Haw, D Fareed, F Hemraj, H Gareeboo, KG Alberti, P Zimmet
BMJ (Clinical research ed.) 1996
Impact of hydrogenated fat consumption on endogenous cholesterol synthesis and susceptibility of low-density lipoprotein to oxidation in moderately hypercholesterolemic individuals
M Cuchel, US Schwab, PJ Jones, S Vogel, C Lammi-Keefe, Z Li, J Ordovas, JR McNamara, EJ Schaefer, AH Lichtenstein
Metabolism 1996
The in vitro antioxid ant activity of trilinolein and other lipid-related natural substances as measured by enhanced chemiluminescence
P Chan, JT Cheng, CW Tsao, CS Niu, CY Hong
Life Sciences 1996
Oxidation of lipoprotein(a) and low density lipoprotein containing density gradient ultracentrifugation fractions
HA Kleinveld, PF Duif, HL Pekelharing, HJ van Rijn
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1996
Lipoprotein composition in NIDDM: effects of dietary oleic acid on the composition, oxidisability and function of low and high density lipoproteins
E Dimitriadis, M Griffin, P Collins, A Johnson, D Owens, GR Tomkin
Diabetologia 1996
How Different Constituents of Low Density Lipoprotein Determine its Oxidizability by Copper: A Correlational Approach
A Kontush, C Hübner, B Finckh, A Kohlschüttr, U Beisiegel
Free Radical Research 1996
Oxidative Stress and Lipids in Diabetes: A Role in Endothelium Vasodilator Dysfunction?
RM Tribe, L Poston
Vascular medicine (London, England) 1996
Effects of Fish Oil on Oxidation Resistance of VLDL in Hypertriglyceridemic Patients
MF Hau, AH Smelt, AJ Bindels, EJ Sijbrands, AV der Laarse, W Onkenhout, W van Duyvenvoorde, HM Princen
Arteriosclerosis, thrombosis, and vascular biology 1996
Effect of Antioxidants Alone and in Combination With Monounsaturated Fatty Acid–Enriched Diets on Lipoprotein Oxidation
P Reaven, B Grasse, J Barnett
Arteriosclerosis, thrombosis, and vascular biology 1996
Effect of Dietary Fat Saturation on LDL Oxidation and Monocyte Adhesion to Human Endothelial Cells In Vitro
P Mata, R Alonso, A Lopez-Farre, JM Ordovas, C Lahoz, C Garces, C Caramelo, R Codoceo, E Blazquez, M de Oya
Arteriosclerosis, thrombosis, and vascular biology 1996
Oxidation-Specific Epitopes in Human Coronary Atherosclerosis Are Not Limited to Oxidized Low-Density Lipoprotein
KD O'Brien, CE Alpers, JE Hokanson, S Wang, A Chait
Circulation 1996
Drugs Affecting Lipid Metabolism
AM Gotto, R Paoletti, LC Smith, AL Catapano, AS Jackson
1996
Effect of lipid transfer activity and lipolysis on low density lipoprotein (LDL) oxidizability: evidence for lipolysis-generated non-esterified fatty acids as inhibitors of LDL oxidation
L Viens, A Athias, G Lizard, G Simard, S Gueldry, S Braschi, P Gambert, C Lallemant, L Lagrost
Journal of lipid research 1996
Linoleic acid and TNF-alpha cross-amplify oxidative injury and dysfunction of endothelial cells
M Toborek, SW Barger, MP Mattson, S Barve, CJ McClain, B Hennig
Journal of lipid research 1996
Macrophage oxidative modification of low density lipoprotein occurs independently of its binding to the low density lipoprotein receptor
RK Tangirala, MJ Mol, D Steinberg
Journal of lipid research 1996
Influence of Dietary Fatty Acids on the Atherogenic Lipoprotein Phenotype
BA Griffin, A Zampelas
Nutrition Research Reviews 1995
The low density lipoprotein oxidation hypothesis
E Mohleriii
ACC Current Journal Review 1995
Effect of low-dose simvastatin on cholesterol levels, oxidative susceptibility, and antioxidant levels of low-density lipoproteins in patients with hypercholesterolemia: a pilot study
H Yoshida, T Ishikawa, M Ayaori, H Shige, H Hosoai, E Nishio, K Tomiyasu, T Yamashita, M Suzukawa, M Nishiwaki, K Ikewari, H Nakamura
Clinical Therapeutics 1995
Oxidation of low density lipoproteins from patients with renal failure or renal transplants
WH Sutherland, RJ Walker, MJ Ball, SA Stapley, MC Robertson
Kidney International 1995
Impaired resistance to oxidation of low density lipoprotein in cystic fibrosis: Improvement during vitamin E supplementation
BM Winklhofer-Roob, O Ziouzenkova, H Puhl, H Ellemunter, P Greiner, G Müller, MA Hof, H Esterbauer, DH Shmerling
Free radical biology & medicine 1995
Enhanced resistance to oxidation of low density lipoproteins and decreased lipid peroxide formation during β-carotene supplementation in cystic fibrosis
BM Winklhofer-Roob, H Puhl, G Khoschsorur, MA Hof, H Esterbauer, DH Shmerling
Free radical biology & medicine 1995
Insights Into the Pathogenesis and Prevention of Coronary Artery Disease
JH O'Keefe, CJ Lavie, BD Mccallister
Mayo Clinic Proceedings 1995
Antioxidative activity of ubiquinol-10 at physiologic concentrations in human low density lipoprotein
A Kontush, C Hübner, B Finckh, A Kohlschütter, U Beisiegel
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1995
Oxidized lipoproteins
KR Bruckdorfer
Baillière's Clinical Endocrinology and Metabolism 1995
Dietary fish oil enhances plasma and LDL oxidative modification in rats
M Nardini, M D'Aquino, G Tomassi, V Gentili, MD Felice, C Scaccini
The Journal of Nutritional Biochemistry 1995
Supplementation With Low Doses of Vitamin E Protects LDL From Lipid Peroxidation in Men and Women
HM Princen, W van Duyvenvoorde, R Buytenhek, A van der Laarse, G van Poppel, JA Leuven, VW van Hinsbergh
Arteriosclerosis, thrombosis, and vascular biology 1995
Compared With Dietary Monounsaturated and Saturated Fat, Polyunsaturated Fat Protects African Green Monkeys From Coronary Artery Atherosclerosis
LL Rudel, JS Parks, JK Sawyer
Arteriosclerosis, thrombosis, and vascular biology 1995
Aminoguanidine Has Both Pro-oxidant and Antioxidant Activity Toward LDL
A Philis-Tsimikas, S Parthasarathy, S Picard, W Palinski, JL Witztum
Arteriosclerosis, thrombosis, and vascular biology 1995
Vitamin E and Fatty Acid Intervention Does Not Attenuate the Progression of Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits
HA Kleinveld, HL Hak-Lemmers, MP Hectors, NJ de Fouw, PN Demacker, AF Stalenhoef
Arteriosclerosis, thrombosis, and vascular biology 1995
Monounsaturated Versus Polyunsaturated Dietary Fat and Serum Lipids: A Meta-analysis
CD Gardner, HC Kraemer
Arteriosclerosis, thrombosis, and vascular biology 1995
Oxidation of low-density lipoprotein in NIDDM: its relationship to fatty acid composition
E Dimitriadis, M Griffin, D Owens, A Johnson, P Collins, GH Tomkin
Diabetologia 1995
Effects of fish oil fatty acids on low density lipoprotein size, oxidizability, and uptake by macrophages
M Suzukawa, M Abbey, PR Howe, PJ Nestel
Journal of lipid research 1995
Measurement of antioxidant activity in lipoproteins using enhanced chemiluminescence
SR Maxwell, O Wiklund, G Bondjers
Atherosclerosis 1994
Dietary fat, olive oil intake and breast cancer risk
JM Martin-Moreno, WC Willett, L Gorgojo, JR Banegas, F Rodriguez-Artalejo, JC Fernandez-Rodriguez, P Maisonneuve, P Boyle
International Journal of Cancer 1994
Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease
M Lorgeril, S Renaud, P Salen, I Monjaud, N Mamelle, JL Martin, J Guidollet, P Touboul, J Delaye
The Lancet 1994
Vascular permeability in diabetics and implications for therapy
EN Wardle
Diabetes Research and Clinical Practice 1994
Low density lipoprotein oxidizability by copper correlates to its initial ubiquinol-10 and polyunsaturated fatty acid content
A Kontush, C Hubner, B Finckh, A Kohlschutter, U Beisiegel
FEBS Letters 1994
Evidence for impaired cellular cholesterol removal mediated by APO A-I containing lipoproteins in patients with familial lecithin: cholesterol acyltransferase deficiency
O Takao, N Rie, I Yoichiro, F Jiri, T Kouki, S Yasushi, H Seikoh, M Ichiro
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1994
Interaction between apo A-I-containing lipoproteins and lecithin:cholesterol acyltransferase
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1994
Effects of alcohol consumption on antioxidant content and susceptibility of low-density lipoprotein to oxidative modification
M Suzukawa, T Ishikawa, H Yoshida, K Hosoai, E Nishio, T Yamashita, H Nakamura, N Hashizume, K Suzuki
Journal of the American College of Nutrition 1994
Natural Antioxidants in Human Health and Disease
M Levine, KR Dhariwal, Y Wang, JB Park, RW Welch
Natural Antioxidants in Human Health and Disease 1994
Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans
PD Reaven, BJ Grasse, DL Tribble
Arteriosclerosis Thrombosis and Vascular Biology 1994
13C-NMR spectroscopy of human atherosclerotic lesions. Relation between fatty acid saturation, cholesteryl ester content, and luminal obstruction
JF Toussaint, JF Southern, V Fuster, HL Kantor
Arteriosclerosis Thrombosis and Vascular Biology 1994
Free Radicals in Diagnostic Medicine
D Armstrong
1994
Protection of low-density lipoprotein from oxidation by 3,4-dihydroxyphenylethanol
P Grignaffini, P Roma, C Galli, AL Catapano
Lancet 1994
Diet and Health: What Should We Eat?
WC Willett
Science 1994
Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells
LS Alexander-North, JA North, KP Kiminyo, GR Buettner, AA Spector
Journal of lipid research 1994
Susceptibility of low-density lipoprotein to oxidative modification
JL Witztum
The American Journal of Medicine 1993
Vitamin E, LDL, and endothelium. Brief oral vitamin supplementation prevents oxidized LDL-mediated vascular injury in vitro
JD Belcher, J Balla, G Balla, DR Jacobs, M Gross, HS Jacob, GM Vercellotti
Arteriosclerosis Thrombosis and Vascular Biology 1993
Comparison of supplementation of RRR-alpha-tocopherol and racemic alpha-tocopherol in humans. Effects on lipid levels and lipoprotein susceptibility to oxidation
PD Reaven, JL Witztum
Arteriosclerosis Thrombosis and Vascular Biology 1993

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