Citations to this article

Interference of glycogenolysis with glycolysis in pancreatic islets from glucose-infused rats.
W J Malaisse, … , V Leclercq-Meyer, A Sener
W J Malaisse, … , V Leclercq-Meyer, A Sener
Published February 1, 1993
Citation Information: J Clin Invest. 1993;91(2):432-436. https://doi.org/10.1172/JCI116219.
View: Text | PDF
Research Article

Interference of glycogenolysis with glycolysis in pancreatic islets from glucose-infused rats.

Abstract

When pancreatic islets isolated from rats infused for 48-72 h with a hypertonic solution of D-glucose were incubated for two successive periods of 10 min each, in the presence first of 16.7 mM and then 2.8 mM D-[U-14C]glucose, the total output of L-lactic acid during the second incubation was as high as that recorded during the first incubation, while the specific radioactivity of L-lactic acid dramatically decreased during the second incubation. In islets from normoglycemic rats, however, the total output of L-lactic acid decreased and its specific radioactivity modestly increased as the concentration of D-glucose was lowered from 16.7 to 2.8 mM. Such contrasting results indicate that in the glycogen-rich islets isolated from glucose-infused rats, the fall in extracellular D-glucose concentration was not accompanied by a parallel fall in glycolytic flux, the decreased utilization of exogenous D-[U-14C]glucose coinciding with stimulation of glycogenolysis. This unusual metabolic situation also coincided with a transient and paradoxical stimulation of insulin release in response to the decrease in extracellular D-glucose concentration. It is proposed, therefore, that the interference of glycogenolysis with glycolysis in pancreatic islets from glucose-infused rats participates in the paradoxical changes in insulin output which represent a typical feature of B-cell glucotoxicity.

Authors

W J Malaisse, C Maggetto, V Leclercq-Meyer, A Sener

×

Total citations by year

Year: 2020 2018 2017 2016 2015 2014 2013 2012 2011 2009 2007 2006 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 Total
Citations: 1 1 2 3 1 5 2 3 1 3 4 2 8 1 5 2 3 4 4 4 5 4 3 4 75
Citation information

Citations to this article (75)

Title and authors Publication Year
Glycogen phosphorylase inhibitor, 2,3-bis[(2E)-3-(4-hydroxyphenyl)prop-2-enamido] butanedioic acid (BF142), improves baseline insulin secretion of MIN6 insulinoma cells.
Nagy L, Béke F, Juhász L, Kovács T, Juhász-Tóth É, Docsa T, Tóth A, Gergely P, Somsák L, Bai P 		PloS one 2020
Glucose-sensing Receptor in Pancreatic Beta-cells
I Kojima 		2018
Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?
FM Ashcroft, M Rohm, A Clark, MF Brereton 		Cell Metabolism 2017
Glycogen phosphorylase inhibition improves beta cell function: Glycogen phosphorylase inhibition in beta cells
L Nagy, J Márton, A Vida, G Kis, É Bokor, S Kun, M Gönczi, T Docsa, A Tóth, M Antal, P Gergely, B Csóka, P Pacher, L Somsák, P Bai 		British Journal of Pharmacology 2017
Role of glycogen metabolism in pancreatic islet beta cell function
WJ Malaisse 		Diabetologia 2016
Rapid Elevation in CMPF May Act As a Tipping Point in Diabetes Development
Y Liu, KJ Prentice, JA Eversley, C Hu, B Batchuluun, K Leavey, JB Hansen, DW Wei, B Cox, FF Dai, W Jia, MB Wheeler 		Cell Reports 2016
Genetic models rule out a major role of beta cell glycogen in the control of glucose homeostasis
J Mir-Coll, J Duran, F Slebe, M García-Rocha, R Gomis, R Gasa, JJ Guinovart 		Diabetologia 2016
Red blood cell storage affects the stability of cytosolic native protein complexes: RBC Native Protein Complexes During Storage
V Pallotta, S Rinalducci, L Zolla 		Transfusion 2015
Insulin release: the receptor hypothesis
WJ Malaisse 		Diabetologia 2014
Effect of cytochalasin B on 3-O-[14C]-methyl-D-glucose or D-[U-14C]glucose handling by BRIN-BD11 cells
S Cetik, A Rzajeva, WJ Malaisse, A Sener 		Biomedical Reports 2014
Uptake and metabolism of d -glucose in isolated acinar and ductal cells from rat submandibular glands: d-glucose handling by isolated salivary cells
S Cetik, A Rzajeva, E Hupkens, WJ Malaisse, A Sener 		Cell Biochemistry and Function 2014
Islets of Langerhans, 2. ed
MS Islam 		Islets of Langerhans, 2. ed. 2014
Islets of Langerhans
S Islam 		2014
D-glucose- and 3-O-methyl-D-glucose-induced upregulation of selected genes in rat hepatocytes and INS1E cells: Re-evaluation of the possible role of hexose phosphorylation
M Svoboda, M Tastenoy, Y Zhang, C Gillet, J Rasschaert, WJ Malaisse, A Sener 		Molecular medicine reports 2013
Paracrine control of glucagon release by somatostatin (Review)
WJ Malaisse 		International journal of molecular medicine 2013
Protective action of Citrullus colocynthis seed extracts against the deleterious effect of streptozotocin on both in vitro glucose-stimulated insulin release from rat pancreatic islets and in vivo glucose homeostasis
N Benariba, W Bellakdhar, R Djaziri, E Hupkens, K Louchami, WJ Malaisse 		Biomedical Reports 2012
Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats
L Belkacemi, G Selselet-Attou, E Hupkens, E Nguidjoe, K Louchami, A Sener, WJ Malaisse 		International Journal of Endocrinology 2012
Insulinotropic action of Citrullus colocynthis seed extracts in rat pancreatic islets
N Benariba, R Djaziri, E Hupkens, K Louchami, WJ Malaisse, A Sener 		Molecular medicine reports 2012
19F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells
WJ Malaisse, Y Zhang, K Louchami, S Sharma, T Dresselaers, U Himmelreich, GW Novotny, T Mandrup-Poulsen, D Waschke, Y Leshch, J Thimm, J Thiem, A Sener 		Archives of Biochemistry and Biophysics 2011
Direct effects of eicosapentaenoic and docosahexaenoic acids on phospholipid and triglyceride fatty acid pattern, glucose metabolism, 86rubidium net uptake and insulin release in BRIN-BD11 cells
Y Zhang, R Crutzen, K Louchami, YA Carpentier, A Sener, WJ Malaisse 		Endocrine 2009
Expression of the electrogenic Na+–HCO3 −-cotransporters NBCe1-A and NBCe1-B in rat pancreatic islet cells
MS Soyfoo, N Bulur, M Virreira, K Louchami, P Lybaert, R Crutzen, J Perret, C Delporte, E Roussa, F Thevenod, L Best, AP Yates, WJ Malaisse, A Sener, R Beauwens 		Endocrine 2009
Fatty acid pattern of pancreatic islet lipids in Goto-Kakizaki rats
MH Giroix, K Louchami, YA Carpentier, A Sener, WJ Malaisse 		Endocrine 2009
Is the glucose-induced phosphate flush in pancreatic islets attributable to gating of volume-sensitive anion channels?
K Louchami, Y Zhang, R Beauwens, WJ Malaisse, A Sener 		Endocrine 2007
L-glutamine and palmitate catabolism in pancreatic islets from rats depleted in long-chain polyunsaturated ω3 fatty acids
Y Zhang, K Louchami, YA Carpentier, WJ Malaisse, A Sener 		Cell Biochemistry and Function 2007
Phospholipid fatty acid pattern and d-glucose metabolism in muscles from ω3 fatty acid-depleted rats
E Agascioglu, Y Zhang, A Sener, L Portois, JM Chardigny, WJ Malaisse, YA Carpentier 		Biochimie 2007
Possible role of carbonic anhydrase in rat pancreatic islets: enzymatic, secretory, metabolic, ionic, and electrical aspects
A Sener, H Jijakli, SZ Asl, P Courtois, AP Yates, S Meuris, LC Best, WJ Malaisse 		American journal of physiology. Endocrinology and metabolism 2007
Opposite effects of d-fructose on total versus cytosolic ATP/ADP ratio in pancreatic islet cells
MH Giroix, E Agascioglu, B Oguzhan, K Louchami, Y Zhang, P Courtois, WJ Malaisse, A Sener 		Biochimica et Biophysica Acta (BBA) - Bioenergetics 2006
Adenine Nucleotide Pattern in Rat Pancreatic Islets Exposed to Nutrient Secretagogues
E Agascioglu, MH Giroix, WJ Malaisse, A Sener 		Endocrine 2006
Anomeric specificity of d-[U-14C]glucose incorporation into glycogen in rat hemidiaphragms
Y Zhang, P Courtois, A Sener, WJ Malaisse 		Biochimie 2004
Isotopic discrimination between D-[1-13C]fructose and D-[2-13C]fructose in rat liver cells
WJ Malaisse, R Willem 		Biochimie 2004
Impaired enzyme-to-enzyme channelling between hexokinase isoenzyme(s) and phosphoglucoisomerase in rat pancreatic islets incubated at a low concentration ofD-glucose
Y Zhang, H Jijakli, P Courtois, A Sener, WJ Malaisse 		Cell Biochemistry and Function 2004
Enzyme-to-enzyme channelling in the early steps of glycolysis in rat pancreatic islets
WJ Malaisse, Y Zhang, H Jijakli, P Courtois, A Sener 		The International Journal of Biochemistry & Cell Biology 2004
Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose
MZ Khaldi, Y Guiot, P Gilon, JC Henquin, JC Jonas 		American journal of physiology. Endocrinology and metabolism 2004
Anomeric specificity of D-glucose production by rat hepatocytes
WJ Malaisse, R Willem 		Molecular and Cellular Biochemistry 2004
Metabolism of tritiated D-glucose anomers in rat erythrocytes
Y Zhang, H Jijakli, P Courtois, A Sener, WJ Malaisse 		Molecular and Cellular Biochemistry 2004
Stimulation of Proinsulin Biosynthesis by K+ in Rat Pancreatic Islets
WJ Malaisse, Y Zhang, J Cancelas, PG Prieto, E Olivares, ML Villanueva-Peñacarrillo, I Valverde 		Endocrine 2004
Labelling of lipids by D-[1-14C]glucose, D-[6-14C] glucose and D-[3-3H]glucose in pancreatic islets from normal and GK rats
H X Zhang, H Jijakli, P Courtois, A Sener, W J Malaisse 		Molecular and Cellular Biochemistry 2003
Beneficial Effect Of T-1095, A Selective Inhibitor Of Renal Na+-Glucose Cotransporters, On Metabolic Index And Insulin Secretion In Spontaneously Diabetic Gk Rats
K Nunoi, K Yasuda, T Adachi, Y Okamoto, N Shihara, M Uno, A Tamon, N Suzuki, A Oku, K Tsuda 		Clinical and Experimental Pharmacology and Physiology 2002
Comparison between d-[3-3H]- and d-[5-3H]glucose and fructose utilization in pancreatic islets from control and hereditarily diabetic rats
MH Giroix, O Scruel, P Courtois, A Sener, B Portha, WJ Malaisse 		Archives of Biochemistry and Biophysics 2002
Metabolism of -[1-13C]Fructose, -[2-13C]Fructose, and -[6-13C]Fructose in Rat Hepatocytes Incubated in the Presence of H2O or D2O
WJ Malaisse, L Ladrière, I Verbruggen, R Willem 		Molecular Genetics and Metabolism 2002
Anomeric Specificity of the Stimulatory Effect ofd-Glucose on d-Fructose Phosphorylation by Human Liver Glucokinase
H Jijakli, P Courtois, HX Zhang, A Sener, WJ Malaisse 		The Journal of biological chemistry 2002
Effects of D-glucose upon D-fructose metabolism in rat hepatocytes: A 13C NMR study
W J Malaisse, L Ladrière, I Verbruggen, R Willem 		Molecular and Cellular Biochemistry 2002
Glycogen Accumulation in Rat Pancreatic Islets: In Vitro Experiments
M Doherty, WJ Malaisse 		Endocrine 2001
Pancreatic and hepatic glycogen content in normoglycemic and hyperglycemic rats
W J Malaisse, L Ladrière, J Cancelas, A Acitores, M L Villanueva-Peñacarrillo, I Valverde 		Molecular and Cellular Biochemistry 2001
Metabolism of α--[1,2-13C]Glucose Pentaacetate and α--Glucose Penta[2-13C]acetate in Rat Hepatocytes
WJ Malaisse, L Ladrière, MM Kadiata, I Verbruggen, R Willem 		Archives of Biochemistry and Biophysics 2000
Metabolism of [1,3-13C]glycreol-1,2,3-tris(methylsuccinate) and glycerol-1,2,3-tris(methyl[2,3-13C]succinate) in rat hepatocytes
WJ Malaisse, L Ladrière, I Verbruggen, G Grue-Sørenson, F Björkling, R Willem 		Metabolism 2000
Stimulus-Secretion Coupling of Arginine-Induced Insulin Release: Comparison Between the Cationic Amino Acid and its Methyl Ester
A Sener, LC Best, AP Yates, MM Kadiata, E Olivares, K Louchami, H Jijakli, L Ladrière, WJ Malaisse 		Endocrine 2000
Metabolism of d-Glucose and Its Pentaacetate Ester in Muscles and Pancreatic Islets of GLUT4 Null Mice
L Ladrière, MJ Charron, WJ Malaisse 		Biochemical and Biophysical Research Communications 1999
Effects of starvation and diabetes on the metabolism of [2,3-13C]succinic acid dimethyl ester in rat hepatocytes
L Ladrière, F Malaisse-Lagae, I Verbruggen, R Willem, WJ Malaisse 		Metabolism 1999
Effects of a Protective Hydrolyzed Casein Diet upon the Metabolic and Secretory Responses of Pancreatic Islets to IL-1β, Cytokine Production by Mesenteric Lymph Node Cells, Mitogenic and Biosynthetic Activities in Peyer's Patch Cells, and Mitogenic Activity in Pancreatic Lymph Node Cells from Control and Diabetes-Prone BB Rats
E Olivares, L Ladrière, A Laghmich, A Sener, WJ Malaisse, FW Scott 		Molecular Genetics and Metabolism 1999
Metabolism of glycerol-1,2,3-trimethylsuccinate in rat hepatocytes
L Ladrière, G Grue-Sørensen, F Björkling, W J Malaisse 		Molecular and Cellular Biochemistry 1999
Failure of streptozotocin tetraacetate to undergo extensive hydrolysis and to inhibitD-glucose metabolism and insulinotropic action in rat pancreatic islets
E Olivares, S Picton, LE Flores, MM Kadiata, WJ Malaisse 		Cell Biochemistry and Function 1998
Insulinotropic Action of α-d-Glucose Pentaacetate: Metabolic Aspects
A Sener, N Welsh, F Malaisse-Lagae, MM Kadiata, WJ Malaisse 		Molecular Genetics and Metabolism 1998
Metabolism of the dimethyl ester of [2,3-(13)C]succinic acid in rat hepatocytes
W J Malaisse, L Ladrière, H Jijakli, R Laatikainen, M Niemitz, I Verbruggen, M Biesernans, R Willem 		Molecular and Cellular Biochemistry 1998
Effect of Repaglinide on Insulin Secretion in Islets from Rats Infused for Two Days with a Hypertonic Solution of D-Glucose
K Louchami, L Ladrière, H Jijakli, WJ Malaisse 		Endocrine 1998
Advances in Molecular and Cell Biology
KJ Clemetson 		Advances in Molecular and Cell Biology 1997
Protective effects of succinic aciddimethyl ester infusion in experimental endotoxemia
WJ Malaisse, AB Nadi, L Ladriere, TM Zhang 		Nutrition 1997
Metabolic Fate of Glucose in Purified Islet Cells: GLUCOSE-REGULATED ANAPLEROSIS IN β CELLS
F Schuit, AD Vos, S Farfari, K Moens, D Pipeleers, T Brun, M Prentki 		The Journal of biological chemistry 1997
Physiology and Pathophysiology of the Islets of Langerhans
B Soria 		1997
Enzyme-to-enzyme channelling of symmetric Krebs cycle intermediates in pancreatic islet cells
WJ Malaisse, L Ladrière, TM Zhang, I Verbruggen, R Willem 		Diabetologia 1996
The coupling of metabolic to secretory events in pancreatic islets. Glucose-induced changes in mitochondrial redox state
R Ramirez, J Rasschaert, A Sener, WJ Malaisse 		Biochimica et Biophysica Acta (BBA) - Bioenergetics 1996
Enzyme-to-enzyme channelling of Krebs cycle metabolic intermediates in Caco-2 cells exposed to [2-13c]propionate
WJ Malaisse, TM Zhang, I Verbruggen, R Willem 		Biochemical Journal 1996
Lessons from Animal Diabetes VI
E Shafrir 		1996
Enzyme-to-enzyme channelling of symmetric Krebs cycle intermediates in pancreatic islet cells
WJ Malaisse, L Ladrière, , I Verbruggen, R Willem 		Diabetologia 1996
Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice
L Jansson, DL Eizirik, DG Pipeleers, LA Borg, C Hellerström, A Andersson 		Journal of Clinical Investigation 1995
Metabolism of succinic acid methyl esters in myocytes
TM Zhang, J Rasschaert, WJ Malaisse 		Clinical Nutrition 1995
NADP-Malate dehydrogenase activity in rat erythrocytes. Comparison with pyruvate kinase in relation to coupling with lactate dehydrogenase
F Malaisse-Lagae, D Zähner, WJ Malaisse 		The International Journal of Biochemistry & Cell Biology 1995
Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence
M Ohneda, LR Inman, RH Unger 		Diabetologia 1995
Glycogen synthase, glycogen phosphorylase and α-amylase activity in homogenates of islets of GK rats: Comparison with hepatic and pancreatic extracts
TM Zhang, CG Östenson, WJ Malaisse 		Cell Biochemistry and Function 1994
Enhancement by succiic acid dimethyl ester of insulin release evoked by d-glucose and glimepiride in the perfused pancreas of normoglycemic and hyperglycemic rats
V Leclercq-Meyer, WJ Malaisse 		Biochemical Pharmacology 1994
The beta cell in NIDDM: giving light to the blind
WJ Malaisse 		Diabetologia 1994
GLUT-2 function in glucose-unresponsive beta cells of dexamethasone-induced diabetes in rats
M Ohneda, JH Johnson, LR Inman, RH Unger 		Journal of Clinical Investigation 1993
Metabolism of endogenous nutrients in islets of Goto-Kakizaki (GK) rats
A Sener, F Malaisse-Lagae, CG Ostenson, WJ Malaisse 		Biochemical Journal 1993
Modulation of the insulinotropic action of glibenclamide and glimepiride by nutrient secretagogues in pancreatic islets from normoglycemic and hyperglycemic rats
WJ Malaisse, P Lebrun, A Sener 		Biochemical Pharmacology 1993
New Concepts in the Pathogenesis of NIDDM
CG Östenson, S Efendić, M Vranic 		1993

Advertisement