Citations to this article

Epidermal keratinocyte-derived basophil promoting activity. Role of interleukin 3 and soluble CD23.
A H Dalloul, … , P Debré, M D Mossalayi
A H Dalloul, … , P Debré, M D Mossalayi
Published October 1, 1992
Citation Information: J Clin Invest. 1992;90(4):1242-1247. https://doi.org/10.1172/JCI115986.
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Research Article

Epidermal keratinocyte-derived basophil promoting activity. Role of interleukin 3 and soluble CD23.

Abstract

Human epidermal keratinocytes (EK) secrete factors able to sustain the proliferation of early myeloid cells and, in particular, the generation of basophils. This activity was previously attributed to IL-3, although no definitive in situ demonstration of this cytokine was provided. In regard to the possible physiological relevance of these data, we investigated herein the nature of EK-derived factors responsible for basophil promotion. Our data show that EK-derived supernatants (EK-sup) contain IL-3 as well as soluble CD23 (sCD23), both known for their colony stimulating activity. Messenger RNA for IL-3 and CD23 were also detected in EK. Blocking experiments using specific neutralizing monoclonal antibodies (mAb) further indicate that EK-derived basophil promoting activity is mainly due to the presence of IL-3 and sCD23 in EK-sup. Furthermore, by contrast to IL-3, sCD23 secretion by EK is cortisone sensitive and highly enhanced by IL-4, suggesting distinct regulatory mechanisms for their production.

Authors

A H Dalloul, M Arock, C Fourcade, J Y Béranger, P Jaffray, P Debré, M D Mossalayi

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Year: 2011 2005 2004 2001 1997 1996 1995 1994 Total
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Citations to this article (14)

Title and authors Publication Year
Cytokines
L Cassetta, G Poli, M Alfano 		Cytokines 2011
Differential Role for CD23 Splice Forms in Apical to Basolateral Transcytosis of IgE/Allergen Complexes
G Montagnac, LC Yu, C Bevilacqua, M Heyman, DH Conrad, MH Perdue, A Benmerah 		Traffic 2005
Intracellular Trafficking of CD23: Differential Regulation in Humans and Mice by Both Extracellular and Intracellular Exons
G Montagnac, A Mollà-Herman, J Bouchet, LC Yu, DH Conrad, MH Perdue, A Benmerah 		Journal of immunology (Baltimore, Md. : 1950) 2005
Skin Immune System: Cutaneous Immunology and Clinical Immunodermatology, Third Edition
E Guigné, J Revuz, JC Roujeau 		Skin Immune System: Cutaneous Immunology and Clinical Immunodermatology, Third Edition 2004
ROLE OF CD23 IN ASTROCYTES INFLAMMATORY REACTION DURING HIV-1 RELATED ENCEPHALITIS
N Dugas, C Lacroix, E Kilchherr, JF Delfraissy, M Tardieu 		Cytokine 2001
CD23/FcεRII: Signaling and Clinical Implication
MD Mossalayi, M Arock, P Debré 		International Reviews of Immunology 1997
B Cell Hybridoma Presents Both B-Cell and T-Cell Epitopes for Stimulating Antibody Production Via CD23 Pathway
R Schmaltz, YY Wang, QX Kung, FT Liu, T Petro, SS Chen 		Immunological Investigations 1996
Failure to Detect Interleukin (IL)-3 mRNA or Protein in Human Keratinocytes: Antibodies to Granulocyte Macrophage--Colony-Stimulating Factor or IL-6 (But Not IL-3) Neutralize "IL-3" Bioactivity
S Kondo, A Ciarletta, KJ Turner, DN Sauder, RC McKenzie 		Journal of Investigative Dermatology 1995
Leukemic erythroderma with elevated plasma IL-3 and hyperhistaminemia: in situ expression of IL-3 mRNA in leukemic cells
H Kishimoto, T Matsunaga, T Yamamoto, H Yokozeki, I Katayama, K Nishioka 		Journal of Dermatological Science 1995
CD23 (FcɛRII) activation induces the nitric oxide synthase pathway in human keratinocytes: possible relevance in cutaneous allergic diseases
PA Bécherel, LL Goff, M Arock 		Research in Immunology 1995
Cytokines: Interleukins and Their Receptors
R Kurzrock, M Talpaz 		1995
Involvement of cyclic AMP and nitric oxide in immunoglobulin E-dependent activation of Fc epsilon RII/CD23+ normal human keratinocytes
PA Bécherel, MD Mossalayi, F Ouaaz, LL Goff, B Dugas, N Paul-Eugène, C Frances, O Chosidow, E Kilchherr, JJ Guillosson 		Journal of Clinical Investigation 1994
CD23 and IgE expression during the human immune response to cutaneous leishmaniasis : Possible role in monocyte activation
I Vouldoukis, F Issaly, C Fourcade, N Paul-Eugène, M Arock, JP Kolb, OA da Silva, L Monjour, H Poinsot, Y Tselentis, B Dugas, P Debré, MD Mossalayi 		Research in Immunology 1994
Functional analysis of human bone-marrow- and thymus-derived early T cells
MD Mossalayi, F Mentz, AH Dalloul, C Blanc, H Merle-Béral, M Arock, P Debré 		Research in Immunology 1994

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