Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.
J P Cooke, … , R A Rowan, M E Billingham
J P Cooke, … , R A Rowan, M E Billingham
Published September 1, 1992
Citation Information: J Clin Invest. 1992;90(3):1168-1172. https://doi.org/10.1172/JCI115937.
View: Text | PDF
Research Article Article has an altmetric score of 15

Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.

  • Text
  • PDF
Abstract

The purpose of this study was to determine if chronic administration of L-arginine, the precursor of endothelium-derived relaxing factor (EDRF), normalizes endothelium-dependent relaxation and decreases atherosclerosis in hypercholesterolemic animals. Male rabbits were fed (a) normal rabbit chow; (b) 1% cholesterol diet; or (c) 1% cholesterol diet supplemented by 2.25% L-arginine HCl in drinking water. Arginine supplementation doubled plasma arginine levels without affecting serum cholesterol values. After 10 wk, the thoracic aorta was harvested for studies of vascular reactivity and histomorphometry. Endothelium-dependent relaxations (to acetylcholine and calcium ionophore A23187) were significantly impaired in thoracic aortae from animals fed a 1% cholesterol diet. By contrast, vessels from hypercholesterolemic animals receiving L-arginine supplementation exhibited significantly improved endothelium-dependent relaxations. Responses to norepinephrine or nitroglycerin were not affected by either dietary intervention. Histomorphometric analysis revealed a reduction in lesion surface area and intimal thickness in thoracic aortae from arginine-supplemented animals compared to those from untreated hypercholesterolemic rabbits. This is the first study to demonstrate that supplementation of dietary L-arginine, the EDRF precursor, improves endothelium-dependent vasorelaxation. More importantly, we have shown that this improvement in EDRF activity is associated with a reduction in atherogenesis.

Authors

J P Cooke, A H Singer, P Tsao, P Zera, R A Rowan, M E Billingham

×

Total citations by year

Year: 2025 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1957 1949 Total
Citations: 1 2 2 3 11 9 12 14 23 17 16 18 17 22 19 16 15 19 19 20 22 14 23 32 45 43 55 55 41 40 32 6 1 1 685
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2016 (23)

Title and authors Publication Year
Gene delivery nanoparticles to modulate angiogenesis
J Kim, AC Mirando, AS Popel, JJ Green
Advanced Drug Delivery Reviews 2016
Tubular Overexpression of Angiopoietin-1 Attenuates Renal Fibrosis
S Singh, SR Manson, H Lee, Y Kim, T Liu, Q Guo, JJ Geminiani, PF Austin, YM Chen, JA Joles
PloS one 2016
Fit for the Eye: Aptamers in Ocular Disorders
DW Drolet, LS Green, L Gold, N Janjic
Nucleic Acid Therapeutics (Formerly Oligonucleotides) 2016
Endothelial-Specific EphA4 Negatively Regulates Native Pial Collateral Formation and Re-Perfusion following Hindlimb Ischemia
B Okyere, K Giridhar, A Hazy, M Chen, D Keimig, RC Bielitz, H Xie, JQ He, WR Huckle, MH Theus, A Caporali
PloS one 2016
Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin
AC Dalton, T Shlamkovitch, N Papo, WA Barton, LR Languino
PloS one 2016
Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans
SD Castillo, E Tzouanacou, M Zaw-Thin, IM Berenjeno, VE Parker, I Chivite, M Mila-Guasch, W Pearce, I Solomon, A Angulo-Urarte, AM Figueiredo, RE Dewhurst, RG Knox, GR Clark, CL Scudamore, A Badar, TL Kalber, J Foster, DJ Stuckey, AL David, WA Phillips, MF Lythgoe, V Wilson, RK Semple, NJ Sebire, VA Kinsler, M Graupera, B Vanhaesebroeck
Science Translational Medicine 2016
Somatic PIK3CA mutations as a driver of sporadic venous malformations
P Castel, FJ Carmona, J Grego-Bessa, MF Berger, A Viale, KV Anderson, S Bague, M Scaltriti, CR Antonescu, E Baselga, J Baselga
Science Translational Medicine 2016
LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways
H Zeng, X He, Q Tuo, D Liao, G Zhang, J Chen
Scientific Reports 2016
How May Proton Pump Inhibitors Impair Cardiovascular Health?
RA Sukhovershin, JP Cooke
American Journal Cardiovascular Drugs 2016
Study of pomegranate (Punica granatum L.) peel extract containing anthocyanins on fatty streak formation in the renal arteries in hypercholesterolemic rabbits
Fatemeh Sharifiyan, Ahmad Movahedian-Attar, Nafiseh Nili, Sedigheh Asgary
Advanced Biomedical Research 2016
Autologous endothelial progenitor cells improve allograft survival in porcine lung transplantation with prolonged ischemia
YT Yen, JN Roan, SY Fang, SW Chang, YL Tseng, CF Lam
Annals of translational medicine 2016
Fibulin-5 Regulates Angiopoietin-1/Tie-2 Receptor Signaling in Endothelial Cells
W Chan, H Ismail, D Mayaki, V Sanchez, K Tiedemann, EC Davis, SN Hussain, N Takakura
PloS one 2016
Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas
D Kitajima, A Kasamatsu, D Nakashima, I Miyamoto, Y Kimura, T Saito, T Suzuki, Y Endo-Sakamoto, M Shiiba, H Tanzawa, K Uzawa
Journal of Cancer 2016
Biodegradable Mg-Cu alloys with enhanced osteogenesis, angiogenesis, and long-lasting antibacterial effects
C Liu, X Fu, H Pan, P Wan, L Wang, L Tan, K Wang, Y Zhao, K Yang, PK Chu
Scientific Reports 2016
Discovery of Novel Antiangiogenic Marine Natural Product Scaffolds
H Ebrahim, KE Sayed
Marine drugs 2016
New Insights into the Pro-Inflammatory Activities of Ang1 on Neutrophils: Induction of MIP-1β Synthesis and Release
E Dumas, PE Neagoe, PP McDonald, M White, MG Sirois, BL Diaz
PloS one 2016
Angiopoietin-1 facilitates recovery of hematopoiesis in radiated mice
Lan Sun, Huaibao Zhang, Laixi Bi, Yi-Fen Shi, Chongyun Xing, Liyuan Tang, Songfu Jiang, Kang Yu
American journal of translational research 2016
Circulating Angiopoietin-1 Is Not a Biomarker of Disease Severity or Prognosis in Pulmonary Hypertension
MJ Richter, SL Tiede, N Sommer, T Schmidt, W Seeger, HA Ghofrani, R Schermuly, H Gall, J West
PloS one 2016
Pharmacological Tie2 activation in kidney transplantation
K Thamm, F Njau, PV Slyke, DJ Dumont, JK Park, H Haller, S David
World Journal of Transplantation 2016
Therapeutic ultrasound reverses peripheral ischemia in type 2 diabetic mice through PI3K-Akt-eNOS pathway
Zhao-Yang Lu, Rui-Lin Li, Hong-Sheng Zhou, Jing-Juan Huang, Zhi-Xiao Su, Jia Qi, Lan Zhang, Yue Li, Yi-Qin Shi, Chang-Ning Hao, Jun-Li Duan
American journal of translational research 2016
Prazosin Can Prevent Glucocorticoid Mediated Capillary Rarefaction
ER Mandel, EC Dunford, A Trifonova, G Abdifarkosh, T Teich, MC Riddell, TL Haas, AP Gadeau
PloS one 2016
Luteal function during the estrous cycle in arginine-treated ewes fed different planes of nutrition
CS Bass, DA Redmer, SL Kaminski, AT Grazul-Bilska
Reproduction 2016
Angiopoietin-2: marker or mediator of angiogenesis in continuous-flow left ventricular assist device patients?
LK Truby, VK Topkara
Journal of Thoracic Disease 2016

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 2 policy sources
Referenced in 16 patents
45 readers on Mendeley
See more details