Advertisement

Research Article Free access | 10.1172/JCI115769

High levels of circulating soluble receptors for tumor necrosis factor in hairy cell leukemia and type B chronic lymphocytic leukemia.

W Digel, F Porzsolt, M Schmid, F Herrmann, W Lesslauer, and M Brockhaus

Department of Internal Medicine III, University of Ulm, Federal Republic of Germany.

Find articles by Digel, W. in: JCI | PubMed | Google Scholar

Department of Internal Medicine III, University of Ulm, Federal Republic of Germany.

Find articles by Porzsolt, F. in: JCI | PubMed | Google Scholar

Department of Internal Medicine III, University of Ulm, Federal Republic of Germany.

Find articles by Schmid, M. in: JCI | PubMed | Google Scholar

Department of Internal Medicine III, University of Ulm, Federal Republic of Germany.

Find articles by Herrmann, F. in: JCI | PubMed | Google Scholar

Department of Internal Medicine III, University of Ulm, Federal Republic of Germany.

Find articles by Lesslauer, W. in: JCI | PubMed | Google Scholar

Department of Internal Medicine III, University of Ulm, Federal Republic of Germany.

Find articles by Brockhaus, M. in: JCI | PubMed | Google Scholar

Published May 1, 1992 - More info

Published in Volume 89, Issue 5 on May 1, 1992
J Clin Invest. 1992;89(5):1690–1693. https://doi.org/10.1172/JCI115769.
© 1992 The American Society for Clinical Investigation
Published May 1, 1992 - Version history
View PDF
Abstract

The presence of soluble tumor necrosis factor (TNF) binding proteins (BP) was investigated in the sera of healthy volunteer blood donors and cancer patients. Two distinct types of TNFBP, types A and B, which are immunologically related to the cellular 75-kD TNF receptor (TNFR) and the cellular 55-kD TNFR, respectively, were assessed by immunoassays using nonblocking anti-receptor antibodies and 125I-recombinant human TNF alpha. As compared to the titers observed in 25 healthy controls, TNFBP types A and B titers were found to be elevated in almost all sera obtained from patients with underlying malignant disease. The highest amounts of TNFBP were seen in the sera of patients with B cell malignancies including hairy cell leukemia (HCL) and type B chronic lymphocytic leukemia. Treatment of HCL patients with recombinant human interferon-alpha was associated with decrease of circulating TNFBP.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (May 1, 1992): No description
Advertisement
Advertisement