Nitric oxide (NO) has been proposed to modulate the renal response to protein as well as basal renal hemodynamics. We investigated whether NO and angiotensin II (AII) interact to control glomerular hemodynamics and absolute proximal tubular reabsorption (APR) during glycine infusion and in unstimulated conditions. In control rats, glycine increased single nephron GFR and plasma flow with no change in APR. The NO synthase blocker, NG-monomethyl L-arginine (LNMMA), abolished the vasodilatory response to glycine, possibly through activation of tubuloglomerular feedback due to a decrease in APR produced by LNMMA + glycine. Pretreatment with an AII receptor antagonist, DuP 753, normalized the response to glycine at both glomerular and tubular levels. In unstimulated conditions, LNMMA produced glomerular arteriolar vasoconstriction, decreased the glomerular ultrafiltration coefficient, and reduced single nephron GFR. These changes were associated with a striking decrease in APR. DuP 753 prevented both glomerular and tubular changes induced by LNMMA. In conclusion, NO represents a physiological antagonist of AII at both the glomerulus and tubule in both the basal state and during glycine infusion; and inhibition of NO apparently enhances or uncovers the inhibitory effect of AII on proximal reabsorption.
L De Nicola, R C Blantz, F B Gabbai
Title and authors | Publication | Year |
---|---|---|
Intravenous amino acid for kidney protection: current understanding and future perspectives
Kotani Y, Baiardo Redaelli M, Pruna A, Losiggio R, Cocozza S, Ti LK, Bradic N, Comis M, Landoni G, Bellomo R |
Clinical Kidney Journal | 2024 |
Diabetic Nephropathy and Gaseous Modulators
Juin SK, Ouseph R, Gondim DD, Jala VR, Sen U |
Antioxidants | 2023 |
Brief early life ACE inhibition delays kidney injury in sheep with a solitary functioning kidney
Zoe McArdle, Reetu Singh, Helle Bielefeldt-Ohmann, Karen Moritz, Michiel Schreuder, Kate Denton |
Journal of the American Society of Nephrology | 2022 |
The role of nitric oxide in sepsis-associated kidney injury
Oliveira FR, Assreuy J, Sordi R |
Bioscience Reports | 2022 |
Role of Rho in Salt-Sensitive Hypertension
W Kawarazaki, T Fujita |
International journal of molecular sciences | 2021 |
Kidney and epigenetic mechanisms of salt-sensitive hypertension
W Kawarazaki, T Fujita |
Nature Reviews Nephrology | 2021 |
Renal functional reserve: From physiological phenomenon to clinical biomarker and beyond
AH Jufar, YR Lankadeva, CN May, AD Cochrane, R Bellomo, RG Evans |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2020 |
Conditional Deletion of Smooth Muscle Cullin-3 Causes Severe Progressive Hypertension
Larry Agbor, Anand R. Nair, Jing Wu, Ko-Ting Lu, Deborah Davis, Henry L Keen, Frederick Quelle, James A. McCormick, Jeffrey Singer, Curt D. Sigmund |
JCI Insight | 2019 |
Temperature as a risk factor of emergency department visits for acute kidney injury: a case-crossover study in Seoul, South Korea
SE Kim, H Lee, J Kim, YK Lee, M Kang, Y Hijioka, H Kim |
Environmental Health | 2019 |
Impact of eNOS 27-bp VNTR (4b/a) gene polymorphism with the risk of Systemic Lupus Erythematosus in south Indian subjects
SK Katkam, B Indumathi, FS Tasneem, L Rajasekhar, VK Kutala |
Gene | 2018 |
Nitric Oxide Synthase Inhibition Induces Renal Medullary Hypoxia in Conscious Rats
TW Emans, BJ Janssen, JA Joles, CT Krediet |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2018 |
Flax lignan concentrate attenuate hypertension and abnormal left ventricular contractility via modulation of endogenous biomarkers in two-kidney-one-clip (2K1C) hypertensive rats
SH Sawant, SL Bodhankar |
Revista Brasileira de Farmacognosia | 2016 |
Acute SGLT inhibition normalizes O 2 tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats
J O'Neill, A Fasching, L Pihl, D Patinha, S Franzén, F Palm |
American journal of physiology. Renal physiology | 2015 |
Comprehensive Physiology
SN Cheuvront, RW Kenefick |
Comprehensive Physiology | 2014 |
Pediatric Critical Care Medicine
JL Wynn, JA Hazelzet, TP Shanley, HR Wong, DS Wheeler |
Pediatric Critical Care Medicine | 2014 |
Core Knowledge in Critical Care Medicine
W Krüger, AJ Ludman |
2014 | |
Determinants of kidney oxygen consumption and their relationship to tissue oxygen tension in diabetes and hypertension
P Hansell, WJ Welch, RC Blantz, F Palm |
Clinical and Experimental Pharmacology and Physiology | 2013 |
Nutritional Management of Renal Disease
A Molfino, BR Don, GA Kaysen |
Nutritional Management of Renal Disease | 2013 |
Seldin and Giebisch's The Kidney
CJ Cooper, LD Dworkin, WL Henrich |
Seldin and Giebisch's The Kidney | 2013 |
Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1)
J Strobel, F Müller, O Zolk, B Endreß, J König, MF Fromm, R Maas |
Amino Acids | 2013 |
Frontiers in Neuroscience: Transduction and Integration
D Daniels |
Frontiers in neuroscience | 2013 |
Hyperfiltration and effect of nitric oxide inhibition on renal and endothelial function in humans with uncomplicated type 1 diabetes mellitus
DZ Cherney, HN Reich, S Jiang, R Har, R Nasrallah, RL Hébert, V Lai, JW Scholey, EB Sochett |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2012 |
Brenner and Rector's The Kidney
C Brugnara, KU Eckardt |
Brenner and Rector's The Kidney | 2012 |
Aliskiren inhibits experimental venous thrombosis in two-kidney one- clip hypertensive rats
JM Hermanowicz, A Hermanowicz, P Buczko, A Leszczynska, A Tankiewicz-Kwedlo, A Mogielnicki, W Buczko |
Thrombosis Research | 2012 |
Altered Regulation of Endothelin, Atrial Natriuretic Peptide, and Nitric Oxide Systems in Angiotensin II-induced Hypertension
EH Bae, CS Kim, JS Choi, SK Ma, JU Lee, SW Kim |
Journal of the Korean Society of Hypertension | 2012 |
Hyperfiltration and effect of nitric oxide inhibition on renal and endothelial function in humans with uncomplicated type 1 diabetes mellitus
DZ Cherney, HN Reich, S Jiang, R Har, R Nasrallah, RL Hébert, V Lai, JW Scholey, EB Sochett |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2012 |
Insulin induces the correlation between renal blood flow and glomerular filtration rate in diabetes: implications for mechanisms causing hyperfiltration
L Pihl, P Persson, A Fasching, P Hansell, GF DiBona, F Palm |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2012 |
The Cardiorenal Syndrome: Making the Connection
G Viswanathan, S Gilbert |
International Journal of Nephrology | 2011 |
Functional renal reserve capacity in different stages of chronic kidney disease
S Barai, S Gambhir, N Prasad, RK Sharma, M Ora |
Nephrology | 2010 |
Renal NMDA receptors independently stimulate proximal reabsorption and glomerular filtration
A Deng, SC Thomson |
American journal of physiology. Renal physiology | 2009 |
Cellular mediators of renal vascular dysfunction in hypertension
B Ponnuchamy, RA Khalil |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2009 |
Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury
S Heemskerk, R Masereeuw, FG Russel, P Pickkers |
Nature Reviews Nephrology | 2009 |
Renal NMDA receptors independently stimulate proximal reabsorption and glomerular filtration
A Deng, SC Thomson |
American journal of physiology. Renal physiology | 2009 |
Cellular mediators of renal vascular dysfunction in hypertension
B Ponnuchamy, RA Khalil |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2009 |
The balance of angiotensin II and nitric oxide in kidney diseases
P Singh, A Deng, MR Weir, RC Blantz |
Current Opinion in Nephrology and Hypertension | 2008 |
Endothelial nitric oxide synthase gene polymorphisms and the renal hemodynamic response to L-arginine
DZ Cherney, JW Scholey, J Zhou, J Zimpelmann, C Kennedy, KD Burns, V Lai, JA Miller |
Kidney International | 2008 |
Rosiglitazone Treatment Attenuates Expression of Inflammatory Hallmarks in the Remaining Kidney following Contralateral Nephrectomy
S Efrati, S Berman, A Chachashvili, N Cohen, Z Averbukh, J Weissgarten |
American Journal of Nephrology | 2008 |
L-Serine lowers while glycine increases blood pressure in chronic L-NAME-treated and spontaneously hypertensive rats
RC Mishra, S Tripathy, D Quest, KM Desai, J Akhtar, ID Dattani, V Gopalakrishnan |
Journal of Hypertension | 2008 |
Microcirculation
K Ley |
Microcirculation | 2008 |
Effect of chronic inhibition of converting enzyme on proximal tubule acidification
PL Diaz-Sylvester, MC Fiori, SM Dieguez, AC Müller, ML Lopardo, CE Amorena |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2008 |
Effects on kidney filtration rate by agmatine requires activation of ryanodine channels for nitric oxide generation
J Satriano, R Cunard, OW Peterson, T Dousa, FB Gabbai, RC Blantz |
American journal of physiology. Renal physiology | 2008 |
l -arginine-induced glomerular hyperfiltration response: the roles of insulin and ANG II
M Ruiz, P Singh, SC Thomson, K Munger, RC Blantz, FB Gabbai |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2008 |
NMDA receptor blocker ameliorates ischemia-reperfusion-induced renal dysfunction in rat kidneys
CC Yang, CT Chien, MH Wu, MC Ma, CF Chen |
American journal of physiology. Renal physiology | 2008 |
Coordination of kidney filtration and tubular reabsorption: considerations on the regulation of metabolic demand for tubular reabsorption
RC Blantz, A Deng |
Acta Physiologica Hungarica | 2007 |
Angiotensin II–nitric oxide interaction in the kidney
A Patzak, AE Persson |
Current Opinion in Nephrology and Hypertension | 2007 |
Effect of Losartan Plus Hydrochlorothiazide on Nitric Oxide Status in ???Nondipper??? Hypertensive Patients
R Cammarata, MJ Armas-Hern??ndez, R Hern??ndez-Hern??ndez, MC Armas-Padilla, B Sosa-Canache, B Pacheco, J Guerrero, ZH Israili, M Valasco |
American Journal of Therapeutics | 2007 |
Regulation of kidney function and metabolism: a question of supply and demand
RC Blantz, A Deng, CM Miracle, SC Thomson |
Transactions of the American Clinical and Climatological Association | 2007 |
Glibenclamide Effects on Renal Function and Histology after Acute Hemorrhage in Rats under Sevoflurane Anesthesia
LA Diego, CD Marques, PT Vianna, RM Viero, JR Braz, YM Castiglia |
Renal Failure | 2007 |
Sodium in Health and Disease
P Manunta, M Sciarrone |
Sodium in Health and Disease: The Example of Nonsteroidal Anti-inflammatory Agents | 2007 |
The effect of oral contraceptives on the nitric oxide system and renal function
DZ Cherney, JW Scholey, DC Cattran, AK Kang, J Zimpelmann, C Kennedy, V Lai, KD Burns, JA Miller |
American journal of physiology. Renal physiology | 2007 |
L’insuffisance rénale aiguë
L Jacob |
2007 | |
Nitric Oxide Synthesis in the Adult and Developing Kidney
KH Han, JY Jung, KY Chung, H Kim, J Kim |
Electrolyte & Blood Pressure | 2006 |
Rat Model of Depending Prostaglandin Renal State: Effect of Ketoprofen
MS Silva, YM Castiglia, PT Vianna, RM Viero, JR Braz, ML Cassetari |
Renal Failure | 2006 |
Oxygen consumption in the kidney: Effects of nitric oxide synthase isoforms and angiotensin II
A Deng, CM Miracle, JM Suarez, M Lortie, J Satriano, SC Thomson, KA Munger, RC Blantz |
Kidney International | 2005 |
Early detection of progressive renal dysfunction in patients with coronary artery disease
G Fuiano, D Mancuso, C Indolfi, A Mongiardo, M Sabbatini, G Conte, LD Nicola, R Minutolo, G Mazza, P Cianfrone, M Andreucci |
Kidney International | 2005 |
The Pathophysiology of Acute Renal Failure
N Lameire |
Critical Care Clinics | 2005 |
Renal cortical and medullary blood flow responses to l -NAME and ANG II in wild-type, nNOS null mutant, and eNOS null mutant mice
DL Mattson, CJ Meister |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2005 |
Impairment of phenylalanine conversion to tyrosine inend-stage renal disease causing tyrosine deficiency
Y Boirie, R Albright, M Bigelow, KS Nair |
Kidney International | 2004 |
Potential role of kinins in the effects of taurine in high-fructose-fed rats
AT Nandhini, V Thirunavukkarasu, CV Anuradha |
Canadian Journal of Physiology and Pharmacology | 2004 |
Are the oxygen costs of kidney function highly regulated?
RC Blantz, MR Weir |
Current Opinion in Nephrology and Hypertension | 2004 |
Nitric oxide and tubulointerstitial nephritides
J Mattana, A Adamidis, PC Singhal |
Seminars in Nephrology | 2004 |
Pathophysiology of ischaemic acute renal failure
NH Lameire, R Vanholder |
Best Practice & Research Clinical Anaesthesiology | 2004 |
Protein intake regulates the vasodilatory function of the kidney and NMDA receptor expression
LA Slomowitz, FB Gabbai, SJ Khang, J Satriano, S Thareau, A Deng, SC Thomson, RC Blantz, KA Munger |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2004 |
Candesartan cilexetil protects cavernous tissue in spontaneously hypertensive rats
JE Toblli, I Stella, ON Mazza, L Ferder, F Inserra |
International Journal of Impotence Research | 2004 |
Angiotensin Vol. II
T Unger, BA Schölkens |
2004 | |
Possible impact of nitric oxide on the antihypertensive effect of captopril and zaprinast
MA Ibrahim, N Satoh, S Ueda |
Advances in Therapy | 2003 |
Role of angiotensin II in L-NAME-induced systemic and renal hemodynamic effects in hydrochlorothiazide-pretreated hypertensive subjects
NA van der Linde, AH van Meiracker, F Boomsma |
Journal of Hypertension | 2003 |
Down-regulation of soluble guanylyl cyclase in the inner medulla of DOCA-salt hypertensive rats
TA Taylor, JS Pollock, DM Pollock |
Vascular Pharmacology | 2003 |
Differential regulation of glomerular arginine transporters (CAT-1 and CAT-2) in lipopolysaccharide-treated rats
D Schwartz, IF Schwartz, E Gnessin, Y Wollman, T Chernichovsky, M Blum, A Iaina |
American journal of physiology. Renal physiology | 2003 |
Arginase inhibition slows the progression of renal failure in rats with renal ablation
M Sabbatini, A Pisani, F Uccello, G Fuiano, R Alfieri, A Cesaro, B Cianciaruso, VE Andreucci |
American journal of physiology. Renal physiology | 2003 |
Role of some vasoactive mediators in patients with erectile dysfunction: their relationship with angiotensin-converting enzyme and growth hormone
EA Hamed, AR Meki, AA Gaafar, SA Hamed |
International Journal of Impotence Research | 2003 |
Decreases in Renal Functional Reserve and Proximal Tubular Fluid Output in Conscious Oophorectomized Rats: Normalization with Sex Hormone Substitution
CB Nielsen, A Flyvbjerg, JM Bruun, A Forman, L Wogensen, K Thomsen |
Journal of the American Society of Nephrology : JASN | 2003 |
Vasodilatory N-methyl-D-aspartate receptors are constitutively expressed in rat kidney
A Deng, JM Valdivielso, KA Munger, RC Blantz, SC Thomson |
Journal of the American Society of Nephrology : JASN | 2002 |
The complex role of nitric oxide in the regulation of glomerular ultrafiltration
RC Blantz, A Deng, M Lortie, K Munger, V Vallon, FB Gabbai, SC Thomson |
Kidney International | 2002 |
Acute Renal Failure: Is Nitric Oxide the Bad Guy?
JM Valdivielso, RC Blantz |
Antioxidants & Redox Signaling | 2002 |
Renal functional reserve is impaired in patients with systemic sclerosis without clinical signs of kidney involvement
R Livi, L Teghini, A Pignone, S Generini, M Matucci-Cerinic, M Cagnoni |
Annals of the rheumatic diseases | 2002 |
Effects Of Glycine On Glomerular Filtration Rate And Segmental Tubular Handling Of Sodium In Conscious Rats
K Thomsen, CB Nielsen, A Flyvbjerg |
Clinical and Experimental Pharmacology and Physiology | 2002 |
Nitric oxide synthase isoform expression in acute versus chronic anti-Thy 1 nephritis
M Ketteler, R Westenfeld, A Gawlik, S Bachmann, A Frey, G Schonfelder, M Paul, A Distler, ED Heer |
Kidney International | 2002 |
Glucose stimulates O 2 consumption, NOS, and Na/H exchange in diabetic rat proximal tubules
A Baines, P Ho |
American journal of physiology. Renal physiology | 2002 |
New Roles for Old Holes: Ion Channel Function in Aquaporin-1
AJ Yool, AM Weinstein |
Physiology (Bethesda, Md.) | 2002 |
Role of iNOS and eNOS in modulating proximal tubule transport and acid-base balance
T Wang |
American journal of physiology. Renal physiology | 2002 |
Glomerular and tubular responses to NG -nitro- l -arginine methyl ester are age dependent in conscious lambs
A Sener, FG Smith |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2002 |
The Effect of Losartan Potassium on Choroidal Hemodynamics in Healthy Subjects:
T Spicher, S Orgl, K Gugleta, B Teuchner, J Flammer |
Journal of Glaucoma | 2002 |
Nitric Oxide Modulation of Neurally Induced Proximal Tubular Fluid Reabsorption in the Rat
XC Wu, EJ Johns |
Hypertension | 2002 |
Renal interstitial cGMP mediates natriuresis by direct tubule mechanism
XH Jin, HM Siragy, RM Carey |
Hypertension | 2001 |
Nitric Oxide Inhibition and Renal Alterations
B Jover, A Mimran |
Journal of Cardiovascular Pharmacology | 2001 |
Plasma levels of angiotensin II during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction
AJ Becker, S Ückert, CG Stief, F Scheller, WH Knapp, U Hartmann, U Jonas |
Urology | 2001 |
Possible role of bradykinin and angiotensin II in the regulation of penile erection and detumescence
AJ Becker, S Ückert, CG Stief, MC Truss, S Machtens, F Scheller, WH Knapp, U Hartmann, U Jonas |
Urology | 2001 |
An analysis of renal nitric oxide contribution to hyperfiltration in diabetic rats
D Schwartz, IF Schwartz, RC Blantz |
Journal of Laboratory and Clinical Medicine | 2001 |
Implications from the Heart Outcomes Prevention Evaluation Study:
MR Weir, RC Blantz |
Current Opinion in Nephrology and Hypertension | 2001 |
Inducible nitric oxide synthase and glomerular hemodynamics in rats with liver cirrhosis
M Porst, A Hartner, H Krause, KF Hilgers, R Veelken |
American journal of physiology. Renal physiology | 2001 |
The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney
M Kakoki, AP Zou, DL Mattson |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2001 |
Mechanism underlying diuretic effect of l -NAME at a subpressor dose
M Liang, TJ Berndt, FG Knox |
American journal of physiology. Renal physiology | 2001 |
Early Alteration in Glomerular Reserve in Humans at Genetic Risk of Essential Hypertension: Mechanisms and Consequences
DT OConnor, EA Tyrell, MT Kailasam, LM Miller, JA Martinez, RR Henry, RJ Parmer, FB Gabbai |
Hypertension | 2001 |
Interaction of Angiotensin II and Nitric Oxide in Isolated Perfused Afferent Arterioles of Mice
A Patzak, R Mrowka, E Storch, B Hocher, PB Persson |
Journal of the American Society of Nephrology : JASN | 2001 |
Heparin-binding EGF-like growth factor contributes to reduced glomerular filtration rate during glomerulonephritis in rats
L Feng, GE Garcia, Y Yang, Y Xia, FB Gabbai, OW Peterson, JA Abraham, RC Blantz, CB Wilson |
Journal of Clinical Investigation | 2000 |
Role of macula densa nitric oxide and cGMP in the regulation of tubuloglomerular feedback
Y Ren, JL Garvin, OA Carretero |
Kidney International | 2000 |
Abnormal pressure-natriuresis in hypertension: role of nitric oxide
Granger, Alexander |
Acta Physiologica Scandinavica | 2000 |
Biological effects of arginine metabolites
Blantz, Satriano, Gabbai, Kelly |
Acta Physiologica Scandinavica | 2000 |
Therapeutic potential of ACE inhibitors for the treatment of hypertension in Type 2 diabetes
R Komers, K Komersova |
Expert Opinion on Investigational Drugs | 2000 |
Effect of nitric oxide modulation on TGF-β1 and matrix proteins in chronic cyclosporine nephrotoxicity
FS Shihab, H Yi, WM Bennett, TF Andoh |
Kidney International | 2000 |
Nitric oxide inhibits growth of glomerular mesangial cells: Role of the transcription factor EGR-1
HD Rupprecht, Y Akagi, A Keil, G Hofer |
Kidney International | 2000 |
Long-Term Oral Intake of Low-Dose Cadmium Exacerbates Age-Related Impairment of Renal Functional Reserve in Rats
K Uriu, K Kaizu, YL Qie, A Ito, I Takagi, K Suzuka, Y Inada, O Hashimoto, S Eto |
Toxicology and Applied Pharmacology | 2000 |
Production and functional roles of nitric oxide in the proximal tubule
M Liang, FG Knox |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2000 |
Role of neuronal nitric oxide synthase (NOS1) in the pathogenesis of renal hemodynamic changes in diabetes
R Komers, JN Lindsley, TT Oyama, KM Allison, S Anderson |
American journal of physiology. Renal physiology | 2000 |
Defective fluid and HCO 3− absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice
T Wang, FM Inglis, RG Kalb |
American journal of physiology. Renal physiology | 2000 |
ACUTE EFFECTS OF RAPAMYCIN ON GLOMERULAR DYNAMICS: A MICROPUNCTURE STUDY IN THE RAT:
M Sabbatini, G Sansone, F Uccello, LD Nicola, F Nappi, VE Andreucci |
Transplantation | 2000 |
Effects of Systemic Inhibition of Neuronal Nitric Oxide Synthase in Diabetic Rats
R Komers, TT Oyama, JG Chapman, KM Allison, S Anderson |
Hypertension | 2000 |
Nitric Oxide Synthase Activity and Isoforms in Rat Renal Vasculature
DL Mattson, F Wu |
Hypertension | 2000 |
Randomized, double-blind, placebo-controlled study of arginine supplementation in chronic renal failure
LD Nicola, V Bellizzi, R Minutolo, M Andreucci, A Capuano, G Garibotto, G Corso, VE Andreucci, B Cianciaruso |
Kidney International | 1999 |
Endothelin and angiotensin mediate most glomerular responses to nitric oxide inhibition
C Qiu, C Baylis |
Kidney International | 1999 |
Nitric oxide reduces the molecular activity of Na+,K+-ATPase in opossum kidney cells
M Liang, FG Knox |
Kidney International | 1999 |
EFFECT OF HYPERINSULINAEMIA ON RENAL FUNCTION AND NITRATE/NITRITE EXCRETION IN HEALTHY SUBJECTS*
R Komers, T Pelikanova, L Kazdova |
Clinical and Experimental Pharmacology and Physiology | 1999 |
Action of AT1 receptor antagonists on angiotensin II-induced tone in human isolated subcutaneous resistance arteries
RS Garcha, PS Sever, AD Hughes |
British Journal of Pharmacology | 1999 |
Endothelin mediates renal vascular memory of a transient rise in perfusion pressure due to NOS inhibition
XZ Zhang, C Baylis |
The American journal of physiology | 1999 |
Angiotensin II and nitric oxide: a question of balance
LJ Millatt, EM Abdel-Rahman, HM Siragy |
Regulatory Peptides | 1999 |
Nitric Oxide Synthase Isotype Expression in Salt-Sensitive and Salt-Resistant Dahl Rats
Z Ni, F Oveisi, ND Vaziri |
Hypertension | 1999 |
Salt intake determines the renal response to L-arginine infusion in normal human subjects
YM Barri, CS Wilcox |
Kidney International | 1998 |
Effects of prostaglandins and nitric oxide on the renal effects of angiotensin II in the anaesthetized rat
JS Clayton, KL Clark, EJ Johns, GM Drew |
British Journal of Pharmacology | 1998 |
Is the nitric oxide system involved in genetic hypertension in Dahl rats?
AY Deng |
Kidney International | 1998 |
Chronic nitric oxide inhibition model six years on
R Zatz, C Baylis |
Hypertension | 1998 |
Angiotensin II signaling activates the NO-cGMP pathway in rat proximal tubules
C Zhang, PR Mayeux |
Life Sciences | 1998 |
Losartan Inhibits Experimental Venous Thrombosis in Spontaneously Hypertensive Rats
E Chabielska, R Pawlak, J Golatowski, R Rółkowski, D Pawlak, W Buczko |
Thrombosis Research | 1998 |
Effect of Nitric Oxide Inhibition on Blood Pressure and Renal Function in TGR(mRen2)27 Rats
IO Dedeoglu, JE Springate |
Pediatric Research | 1998 |
Role of Angiotensin II, Endothelin-1, and Nitric Oxide in HgCl2-Induced Acute Renal Failure
H Yanagisawa, M Nodera, Y Umemori, Y Shimoguchi, O Wada |
Toxicology and Applied Pharmacology | 1998 |
Pathophysiology of pre-renal azotemia
RC Blantz |
Kidney International | 1998 |
Role of nitric oxide in the control of renin secretion
A Kurtz, C Wagner |
American journal of physiology. Renal physiology | 1998 |
NO generation and action during changes in salt intake: roles of nNOS and macula densa
CS Wilcox, X Deng, WJ Welch |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 1998 |
Systemic inhibition of nitric oxide and prostaglandins in volume-induced natriuresis and hypertension
JD Krier, JC Romero |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 1998 |
Inhibition of proximal tubular fluid absorption by nitric oxide and atrial natriuretic peptide in rat kidney
E Eitle, S Hiranyachattada, H Wang, PJ Harris |
American journal of physiology. Cell physiology | 1998 |
Inducible Nitric Oxide Synthase and Blood Pressure
DL Mattson, CY Maeda, TD Bachman, AW Cowley |
Hypertension | 1998 |
Early Impairment of Renal Hemodynamic Reserve in Patients With Asymptomatic Heart Failure Is Restored by Angiotensin II Antagonism
P Magri, MA Rao, S Cangianiello, V Bellizzi, R Russo, AF Mele, M Andreucci, B Memoli, LD Nicola, M Volpe |
Circulation | 1998 |
Critical Care Nephrology
C Ronco, R Bellomo |
1998 | |
Stickstoffmonoxid, L-Arginin und die Niere: Experimentelle Studien zu neuen Therapieansätzen
M Ketteler, F Abou-Rebyeh, A Frey, A Gawlik, H Peters, R Westenfeld, A Distler |
Medizinische Klinik | 1998 |
The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats
HM Siragy, RM Carey |
Journal of Clinical Investigation | 1997 |
Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats
D Schwartz, M Mendonca, I Schwartz, Y Xia, J Satriano, CB Wilson, RC Blantz |
Journal of Clinical Investigation | 1997 |
ROLE OF MESANGIAL CELLS IN MACULA DENSA TO AFFERENT ARTERIOLE INFORMATION TRANSFER
MS Goligorsky, K Iijima, Y Krivenko, H Tsukahara, Y Hu, LC Moore |
Clinical and Experimental Pharmacology and Physiology | 1997 |
NITRIC OXIDE, THE KIDNEY AND HYPERTENSION
C Schnackenberg, AR Patel, KA Kirchner, JP Granger |
Clinical and Experimental Pharmacology and Physiology | 1997 |
ACTIONS OF NITRIC OXIDE ON RENAL EPITHELIAL TRANSPORT
BA Stoos, JL Garvin |
Clinical and Experimental Pharmacology and Physiology | 1997 |
ROLE OF NITRIC OXIDE IN THE CONTROL OF GLOMERULAR MICROCIRCULATINO
S Ito, OA Carretero, K Abe |
Clinical and Experimental Pharmacology and Physiology | 1997 |
Tissue Angiotensin II as a Modulator of Erectile Function. I. Angiotensin Peptide Content, Secretion and Effects in the Corpus Cavernosum
I Kifor, GH Williams, MA Vickers, MP Sullivan, P Jodbert, RG Dluhy |
The Journal of Urology | 1997 |
Negative modulation of nitric oxide production by neurotensin as a putative mechanism of the diuretic action of SR 48692 in rats
T Croci, M Landi, D Gully, JP Maffrand, GL Fur, L Manara |
British Journal of Pharmacology | 1997 |
Blockade of cytochrome P-450 epoxygenase pathway attenuates the natriuresis of NG-monomethyl-l-arginine infusion in the spontaneously hypertensive rat
AA Khraibi, KH Taylor, CR Ramsey, TJ Berndt |
Journal of Laboratory and Clinical Medicine | 1997 |
Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney
A Tojo, WJ Welch, V Bremer, M Kimoto, K Kimura, M Omata, T Ogawa, P Vallance, CS Wilcox |
Kidney International | 1997 |
PROTECTIVE EFFECTS OF DIETARY L-ARGININE SUPPLEMENTATION ON CHRONIC CYCLOSPORINE NEPHROTOXICITY1:
TF Andoh, MP Gardner, WM Bennett |
Transplantation | 1997 |
Abnormal Endothelium-Dependent Responses in Early Radiation Nephropathy
LI Juncos, JC Cornejo, J Gomes, S Baigorria, LA Juncos |
Hypertension | 1997 |
Angiotensin II Blockade Does Not Prevent Renal Effects of L-NAME in Sodium-Repleted Humans
A Montanari, E Tateo, E Fasoli, D Giberti, P Perinotto, A Novarini, P DallAglio |
Hypertension | 1997 |
Effect of Nitric Oxide on DNA Replication Induced by Angiotensin II in Rat Cardiac Fibroblasts
T Takizawa, M Gu, AV Chobanian, P Brecher |
Hypertension | 1997 |
Nitric Oxide and the Kidney
MS Goligorsky, SS Gross |
1997 | |
Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat
MJ Lortie, WF Novotny, OW Peterson, V Vallon, K Malvey, M Mendonca, J Satriano, P Insel, SC Thomson, RC Blantz |
Journal of Clinical Investigation | 1996 |
Effect of angiotensin ii on the renal response to amino acid in rats
GE Garcia, TC Hammond, LM Wead, MM Mendonca, MR Brown, FB Gabbai |
American Journal of Kidney Diseases | 1996 |
Angiotensin II action in isolated microperfused rabbit afferent arterioles is modulated by flow
LA Juncos, YL Ren, S Arima, J Garvin, OA Carretero, S Ito |
Kidney International | 1996 |
Haemodynamic and hormonal responses to long-term inhibition of nitric oxide synthesis in rats with portal hypertension
C Pilette, R Moreau, P Sogni, P Kirstetter, S Cailmail, E Pussard, D Lebrec |
European Journal of Pharmacology | 1996 |
Importance of nitric oxide in the control of renal hemodynamics
C Baylis, C Qiu |
Kidney International | 1996 |
Pathophysiology of the vascular wall: the role of nitric oxide in renal disease
L Raij, E Jaimes, D Castillo, J Guerra, G Westberg |
Prostaglandins Leukotrienes and Essential Fatty Acids | 1996 |
Automated enzymatic determination of urinary nitrates in humans
G Corso, LD Nicola, B Cianciaruso, AD Russo, C Napoli, V Bellizzi |
Current Therapeutic Research | 1996 |
Contribution of Nitric Oxide to the Beneficial Effects of Enalapril in the Fructose-Induced Hyperinsulinemic Rat
Y Erlich, T Rosenthal |
Hypertension | 1996 |
Endocrinology of the Vasculature
JR Sowers |
1996 | |
Autocrine inhibition of Na+/K(+)-ATPase by nitric oxide in mouse proximal tubule epithelial cells
NJ Guzman, MZ Fang, SS Tang, JR Ingelfinger, LC Garg |
Journal of Clinical Investigation | 1995 |
Angiotensin II-induced cardiac fibrosis in the rat is increased by chronic inhibition of nitric oxide synthase
J Hou, H Kato, RA Cohen, AV Chobanian, P Brecher |
Journal of Clinical Investigation | 1995 |
Glomerular actions of nitric oxide
L Raij, C Baylis |
Kidney International | 1995 |
Role of nitric oxide and prostacyclin in the control of renal perfusion in experimental cirrhosis
J Ros, J Clària, W Jiménez, M Bosch-Marcé, P Angeli, V Arroyo, F Rivera, J Rodés |
Hepatology | 1995 |
A possible role for nitric oxide in modulating the functional cyclosporine toxicity by arginine
A Amore, B Gianoglio, D Ghigo, L Peruzzi, MG Porcellini, F Bussolino, C Costamagna, G Cacace, G Picciotto, G Mazzucco, LM Sena, R Coppo |
Kidney International | 1995 |
Nitric Oxide
RA Schroeder, PC Kuo |
Anesthesia & Analgesia | 1995 |
Renin, Angiotensin II, and the Development of Effusions Following Bidirectional Glenn and Fontan Procedures
RD Mainwaring, JJ Lamberti, TL Carter, JW Moore, JC Nelson |
Journal of Cardiac Surgery | 1995 |
Systemic hypotension and diuresis byL-arginine in cirrhotic patients with ascites: Role of nitric oxide
K Tajiri, H Miyakawa, N Izumi, F Marumo, C Sato |
Hepatology | 1995 |
Effect of lipopolysaccharide on nitric oxide synthase activity in rat proximal tubules
PR Mayeux, HR Garner, JD Gibson, VC Beanum |
Biochemical Pharmacology | 1995 |
Effect of Graded Hypoxia on the Induction and Function of Inducible Nitric Oxide Synthase in Rat Mesangial Cells
SL Archer, KA Freude, PJ Shultz |
Circulation research | 1995 |
Renal Vasodilation With l -Arginine: Effects of Dietary Salt
X Deng, WJ Welch, CS Wilcox |
Hypertension | 1995 |
Renal Effects of Acute Amino Acid Infusion in Hypertension Induced by Chronic Nitric Oxide Blockade
C Qiu, K Engels, L Samsell, C Baylis |
Hypertension | 1995 |
Nitric Oxide and Prostaglandins in the Prolonged Effects of Losartan and Ramipril in Hypertension
V Cachofeiro, R Maeso, E Rodrigo, J Navarro, LM Ruilope, V Lahera |
Hypertension | 1995 |
Direct Measurements of Endothelium-Derived Nitric Oxide Release by Stimulation of Endothelin Receptors in Rat Kidney and Its Alteration in Salt-Induced Hypertension
Y Hirata, H Hayakawa, E Suzuki, K Kimura, K Kikuchi, T Nagano, M Hirobe, M Omata |
Circulation | 1995 |
Endogenous nitric oxide synthesis determines sensitivity to the pressor effect of salt
JP Tolins, PJ Shultz |
Kidney International | 1994 |
Glycine Prevents Toxic Tubular Cell Injury
FB Gabbai, OW Peterson, RC Blantz |
Renal Failure | 1994 |
Inducible nitric oxide synthase mRNA and activity in glomerular mesangial cells
PJ Shultz, SL Archer, ME Rosenberg |
Kidney International | 1994 |
Short-term effects of low protein-normal sodium diet on renal function in chronic renal failure
B Cianciaruso, V Bellizzi, A Capuano, G Bovi, A Nastasi, G Conte, LD Nicola |
Kidney International | 1994 |
Nitric Oxide in the Kidney: Synthesis, Localization, and Function
S Bachmann, P Mundel |
American Journal of Kidney Diseases | 1994 |
Role of Nitric Oxide in the Control of Renin Release from the Normal and Hydronephrotic Rat Kidney
E Hackenthal, K Münter, S Fritsch |
Endothelium : journal of endothelial cell research | 1994 |
Mechanism of vasoconstriction induced by chronic inhibition of nitric oxide in rats
N Bank, HS Aynedjian, GA Khan |
Hypertension | 1994 |
Sympathetic baroreceptor responses after chronic NG-nitro-L-arginine methyl ester treatment in conscious rats
KE Scrogin, R Veelken, FC Luft |
Hypertension | 1994 |
Adaptation to increased dietary salt intake in the rat. Role of endogenous nitric oxide
PJ Shultz, JP Tolins |
Journal of Clinical Investigation | 1993 |
Endothelium-derived relaxing factor/nitric oxide modulates angiotensin II action in the isolated microperfused rabbit afferent but not efferent arteriole
S Ito, S Arima, YL Ren, LA Juncos, OA Carretero |
Journal of Clinical Investigation | 1993 |
Arginine feeding modifies cyclosporine nephrotoxicity in rats
LD Nicola, SC Thomson, LM Wead, MR Brown, FB Gabbai |
Journal of Clinical Investigation | 1993 |
Mechanisms of renal hemodynamic regulation in response to protein feeding
LL Woods |
Kidney International | 1993 |
Endothelial Activation and the Kidney: Vasomediator Modulation and Antioxidant Strategies
GM Vercellotti, JP Tolins |
American Journal of Kidney Diseases | 1993 |
L-Arginine and Progressive Glomerulosclerosis
J Mattana, PC Singhal |
American Journal of Kidney Diseases | 1993 |
L-arginine administration normalizes pressure natriuresis in hypertensive Dahl rats
A Patel, S Layne, D Watts, KA Kirchner |
Hypertension | 1993 |
Angiotensin II and renal functional reserve in rats with Goldblatt hypertension
LD Nicola, JA Keiser, RC Blantz, FB Gabbai |
Hypertension | 1992 |
Acute renal failure
RW Schrier |
Kidney International | 1979 |