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Citations to this article

Nitric oxide and angiotensin II. Glomerular and tubular interaction in the rat.
L De Nicola, … , R C Blantz, F B Gabbai
L De Nicola, … , R C Blantz, F B Gabbai
Published April 1, 1992
Citation Information: J Clin Invest. 1992;89(4):1248-1256. https://doi.org/10.1172/JCI115709.
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Research Article

Nitric oxide and angiotensin II. Glomerular and tubular interaction in the rat.

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Abstract

Nitric oxide (NO) has been proposed to modulate the renal response to protein as well as basal renal hemodynamics. We investigated whether NO and angiotensin II (AII) interact to control glomerular hemodynamics and absolute proximal tubular reabsorption (APR) during glycine infusion and in unstimulated conditions. In control rats, glycine increased single nephron GFR and plasma flow with no change in APR. The NO synthase blocker, NG-monomethyl L-arginine (LNMMA), abolished the vasodilatory response to glycine, possibly through activation of tubuloglomerular feedback due to a decrease in APR produced by LNMMA + glycine. Pretreatment with an AII receptor antagonist, DuP 753, normalized the response to glycine at both glomerular and tubular levels. In unstimulated conditions, LNMMA produced glomerular arteriolar vasoconstriction, decreased the glomerular ultrafiltration coefficient, and reduced single nephron GFR. These changes were associated with a striking decrease in APR. DuP 753 prevented both glomerular and tubular changes induced by LNMMA. In conclusion, NO represents a physiological antagonist of AII at both the glomerulus and tubule in both the basal state and during glycine infusion; and inhibition of NO apparently enhances or uncovers the inhibitory effect of AII on proximal reabsorption.

Authors

L De Nicola, R C Blantz, F B Gabbai

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Clinical and Experimental Pharmacology and Physiology 1997
NITRIC OXIDE, THE KIDNEY AND HYPERTENSION
C Schnackenberg, AR Patel, KA Kirchner, JP Granger
Clinical and Experimental Pharmacology and Physiology 1997
ACTIONS OF NITRIC OXIDE ON RENAL EPITHELIAL TRANSPORT
BA Stoos, JL Garvin
Clinical and Experimental Pharmacology and Physiology 1997
ROLE OF NITRIC OXIDE IN THE CONTROL OF GLOMERULAR MICROCIRCULATINO
S Ito, OA Carretero, K Abe
Clinical and Experimental Pharmacology and Physiology 1997
Tissue Angiotensin II as a Modulator of Erectile Function. I. Angiotensin Peptide Content, Secretion and Effects in the Corpus Cavernosum
I Kifor, GH Williams, MA Vickers, MP Sullivan, P Jodbert, RG Dluhy
The Journal of Urology 1997
Negative modulation of nitric oxide production by neurotensin as a putative mechanism of the diuretic action of SR 48692 in rats
T Croci, M Landi, D Gully, JP Maffrand, GL Fur, L Manara
British Journal of Pharmacology 1997
Blockade of cytochrome P-450 epoxygenase pathway attenuates the natriuresis of NG-monomethyl-l-arginine infusion in the spontaneously hypertensive rat
AA Khraibi, KH Taylor, CR Ramsey, TJ Berndt
Journal of Laboratory and Clinical Medicine 1997
Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney
A Tojo, WJ Welch, V Bremer, M Kimoto, K Kimura, M Omata, T Ogawa, P Vallance, CS Wilcox
Kidney International 1997
PROTECTIVE EFFECTS OF DIETARY L-ARGININE SUPPLEMENTATION ON CHRONIC CYCLOSPORINE NEPHROTOXICITY1:
TF Andoh, MP Gardner, WM Bennett
Transplantation 1997
Abnormal Endothelium-Dependent Responses in Early Radiation Nephropathy
LI Juncos, JC Cornejo, J Gomes, S Baigorria, LA Juncos
Hypertension 1997
Angiotensin II Blockade Does Not Prevent Renal Effects of L-NAME in Sodium-Repleted Humans
A Montanari, E Tateo, E Fasoli, D Giberti, P Perinotto, A Novarini, P DallAglio
Hypertension 1997
Effect of Nitric Oxide on DNA Replication Induced by Angiotensin II in Rat Cardiac Fibroblasts
T Takizawa, M Gu, AV Chobanian, P Brecher
Hypertension 1997
Nitric Oxide and the Kidney
MS Goligorsky, SS Gross
1997
Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat
MJ Lortie, WF Novotny, OW Peterson, V Vallon, K Malvey, M Mendonca, J Satriano, P Insel, SC Thomson, RC Blantz
Journal of Clinical Investigation 1996
Effect of angiotensin ii on the renal response to amino acid in rats
GE Garcia, TC Hammond, LM Wead, MM Mendonca, MR Brown, FB Gabbai
American Journal of Kidney Diseases 1996
Angiotensin II action in isolated microperfused rabbit afferent arterioles is modulated by flow
LA Juncos, YL Ren, S Arima, J Garvin, OA Carretero, S Ito
Kidney International 1996
Haemodynamic and hormonal responses to long-term inhibition of nitric oxide synthesis in rats with portal hypertension
C Pilette, R Moreau, P Sogni, P Kirstetter, S Cailmail, E Pussard, D Lebrec
European Journal of Pharmacology 1996
Importance of nitric oxide in the control of renal hemodynamics
C Baylis, C Qiu
Kidney International 1996
Pathophysiology of the vascular wall: the role of nitric oxide in renal disease
L Raij, E Jaimes, D Castillo, J Guerra, G Westberg
Prostaglandins Leukotrienes and Essential Fatty Acids 1996
Automated enzymatic determination of urinary nitrates in humans
G Corso, LD Nicola, B Cianciaruso, AD Russo, C Napoli, V Bellizzi
Current Therapeutic Research 1996
Contribution of Nitric Oxide to the Beneficial Effects of Enalapril in the Fructose-Induced Hyperinsulinemic Rat
Y Erlich, T Rosenthal
Hypertension 1996
Endocrinology of the Vasculature
JR Sowers
1996
Autocrine inhibition of Na+/K(+)-ATPase by nitric oxide in mouse proximal tubule epithelial cells
NJ Guzman, MZ Fang, SS Tang, JR Ingelfinger, LC Garg
Journal of Clinical Investigation 1995
Angiotensin II-induced cardiac fibrosis in the rat is increased by chronic inhibition of nitric oxide synthase
J Hou, H Kato, RA Cohen, AV Chobanian, P Brecher
Journal of Clinical Investigation 1995
Glomerular actions of nitric oxide
L Raij, C Baylis
Kidney International 1995
Role of nitric oxide and prostacyclin in the control of renal perfusion in experimental cirrhosis
J Ros, J Clària, W Jiménez, M Bosch-Marcé, P Angeli, V Arroyo, F Rivera, J Rodés
Hepatology 1995
A possible role for nitric oxide in modulating the functional cyclosporine toxicity by arginine
A Amore, B Gianoglio, D Ghigo, L Peruzzi, MG Porcellini, F Bussolino, C Costamagna, G Cacace, G Picciotto, G Mazzucco, LM Sena, R Coppo
Kidney International 1995
Nitric Oxide
RA Schroeder, PC Kuo
Anesthesia & Analgesia 1995
Renin, Angiotensin II, and the Development of Effusions Following Bidirectional Glenn and Fontan Procedures
RD Mainwaring, JJ Lamberti, TL Carter, JW Moore, JC Nelson
Journal of Cardiac Surgery 1995
Systemic hypotension and diuresis byL-arginine in cirrhotic patients with ascites: Role of nitric oxide
K Tajiri, H Miyakawa, N Izumi, F Marumo, C Sato
Hepatology 1995
Effect of lipopolysaccharide on nitric oxide synthase activity in rat proximal tubules
PR Mayeux, HR Garner, JD Gibson, VC Beanum
Biochemical Pharmacology 1995
Effect of Graded Hypoxia on the Induction and Function of Inducible Nitric Oxide Synthase in Rat Mesangial Cells
SL Archer, KA Freude, PJ Shultz
Circulation research 1995
Renal Vasodilation With l -Arginine: Effects of Dietary Salt
X Deng, WJ Welch, CS Wilcox
Hypertension 1995
Renal Effects of Acute Amino Acid Infusion in Hypertension Induced by Chronic Nitric Oxide Blockade
C Qiu, K Engels, L Samsell, C Baylis
Hypertension 1995
Nitric Oxide and Prostaglandins in the Prolonged Effects of Losartan and Ramipril in Hypertension
V Cachofeiro, R Maeso, E Rodrigo, J Navarro, LM Ruilope, V Lahera
Hypertension 1995
Direct Measurements of Endothelium-Derived Nitric Oxide Release by Stimulation of Endothelin Receptors in Rat Kidney and Its Alteration in Salt-Induced Hypertension
Y Hirata, H Hayakawa, E Suzuki, K Kimura, K Kikuchi, T Nagano, M Hirobe, M Omata
Circulation 1995
Endogenous nitric oxide synthesis determines sensitivity to the pressor effect of salt
JP Tolins, PJ Shultz
Kidney International 1994
Glycine Prevents Toxic Tubular Cell Injury
FB Gabbai, OW Peterson, RC Blantz
Renal Failure 1994
Inducible nitric oxide synthase mRNA and activity in glomerular mesangial cells
PJ Shultz, SL Archer, ME Rosenberg
Kidney International 1994
Short-term effects of low protein-normal sodium diet on renal function in chronic renal failure
B Cianciaruso, V Bellizzi, A Capuano, G Bovi, A Nastasi, G Conte, LD Nicola
Kidney International 1994
Nitric Oxide in the Kidney: Synthesis, Localization, and Function
S Bachmann, P Mundel
American Journal of Kidney Diseases 1994
Role of Nitric Oxide in the Control of Renin Release from the Normal and Hydronephrotic Rat Kidney
E Hackenthal, K Münter, S Fritsch
Endothelium : journal of endothelial cell research 1994
Mechanism of vasoconstriction induced by chronic inhibition of nitric oxide in rats
N Bank, HS Aynedjian, GA Khan
Hypertension 1994
Sympathetic baroreceptor responses after chronic NG-nitro-L-arginine methyl ester treatment in conscious rats
KE Scrogin, R Veelken, FC Luft
Hypertension 1994
Adaptation to increased dietary salt intake in the rat. Role of endogenous nitric oxide
PJ Shultz, JP Tolins
Journal of Clinical Investigation 1993
Endothelium-derived relaxing factor/nitric oxide modulates angiotensin II action in the isolated microperfused rabbit afferent but not efferent arteriole
S Ito, S Arima, YL Ren, LA Juncos, OA Carretero
Journal of Clinical Investigation 1993
Arginine feeding modifies cyclosporine nephrotoxicity in rats
LD Nicola, SC Thomson, LM Wead, MR Brown, FB Gabbai
Journal of Clinical Investigation 1993
Mechanisms of renal hemodynamic regulation in response to protein feeding
LL Woods
Kidney International 1993
Endothelial Activation and the Kidney: Vasomediator Modulation and Antioxidant Strategies
GM Vercellotti, JP Tolins
American Journal of Kidney Diseases 1993
L-Arginine and Progressive Glomerulosclerosis
J Mattana, PC Singhal
American Journal of Kidney Diseases 1993
L-arginine administration normalizes pressure natriuresis in hypertensive Dahl rats
A Patel, S Layne, D Watts, KA Kirchner
Hypertension 1993
Angiotensin II and renal functional reserve in rats with Goldblatt hypertension
LD Nicola, JA Keiser, RC Blantz, FB Gabbai
Hypertension 1992
Acute renal failure
RW Schrier
Kidney International 1979

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