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Citations to this article

Preserved endothelium-dependent vasodilation at the vasospastic site in patients with variant angina.
K Egashira, … , Y Hirooka, A Takeshita
K Egashira, … , Y Hirooka, A Takeshita
Published March 1, 1992
Citation Information: J Clin Invest. 1992;89(3):1047-1052. https://doi.org/10.1172/JCI115646.
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Research Article

Preserved endothelium-dependent vasodilation at the vasospastic site in patients with variant angina.

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Abstract

Endothelial dysfunction has been implicated as a cause of coronary vasospasm in patients with variant angina. This study aimed to determine if endothelium-dependent vasodilation evoked with substance P (SP) was altered at the spastic site where vasospasm was induced by acetylcholine (ACH) in patients with variant angina. It has been shown that SP evokes endothelium-dependent vasodilation with no direct effect on vascular smooth muscle in excised human coronary arteries. SP and ACH were infused into the coronary arteries in nine patients with variant angina in whom coronary arteriograms showed normal or mild atherosclerotic lesions. The vasomotor responses of coronary arteries were assessed by quantitative arteriography. ACH at a high dose (100 micrograms/min) provoked coronary vasospasm associated with anginal attack in all patients. In contrast, SP at graded doses (13.5, 40, and 135 ng/min) caused the dose-dependent and comparable increases in the coronary diameter at the spastic and control sites. ACH at a low dose (10 micrograms/min) also caused comparable vasodilation at the spastic and control sites in patients with normal coronary arteries. Coronary vasodilating responses to SP were comparable in patients with variant angina and those with atypical chest pain. The results indicate that endothelium-dependent vasodilation evoked with SP and ACH at the low dose was present at the vasospastic site in patients with variant angina. These findings suggest that the ACH-induced coronary vasospasm in patients with variant angina results from hyperreactivity of vascular smooth muscle to ACH but not from endothelial dysfunction.

Authors

K Egashira, T Inou, A Yamada, Y Hirooka, A Takeshita

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Total citations by year

Year: 2024 2023 2022 2021 2020 2018 2016 2015 2014 2013 2010 2009 2008 2007 2006 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1949 Total
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Citations to this article in year 2010 (1)

Title and authors Publication Year
Association of the manganese superoxide dismutase polymorphism with vasospastic angina pectoris
H Fujimoto, H Kobayashi, K Ogasawara, M Yamakado, M Ohno
Journal of Cardiology 2010

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