Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Autoimmune disease of the ovary induced by a ZP3 peptide from the mouse zona pellucida.
S H Rhim, … , J Dean, K S Tung
S H Rhim, … , J Dean, K S Tung
Published January 1, 1992
Citation Information: J Clin Invest. 1992;89(1):28-35. https://doi.org/10.1172/JCI115572.
View: Text | PDF
Research Article Article has an altmetric score of 9

Autoimmune disease of the ovary induced by a ZP3 peptide from the mouse zona pellucida.

  • Text
  • PDF
Abstract

We describe a novel experimental system in mice for the study of ovarian autoimmune disease, a condition encountered in women with premature ovarian failure. The ovarian autoimmune disease is induced in B6AF1 mice by a 15-amino acid peptide (Cys-Ser-Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln-Ile-His-Gly-Pro-Arg) from mouse ZP3, the sperm-binding component of the zona pellucida that surrounds growing and mature oocytes. Whereas the peptide induces both T cell and antibody responses, adoptive transfer of CD4+ T cell lines derived from affected animals causes oophoritis without observable antibodies to the zona pellucida peptide. The primacy of the T cell response in the pathogenesis of disease is further substantiated by defining oophoritogenic peptides as small as eight amino acids (Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln) that do not elicit an antibody response to the full-length ZP3 peptide. The identification of a well characterized peptide as a causative agent of autoimmune oophoritis should facilitate understanding of the pathogenesis of this T cell-mediated autoimmune disease. Because the proteins of the zona pellucida are conserved among mammals (the mouse and human ZP3 proteins are 67% identical), this murine model may lead to better understanding of the pathogenesis of human autoimmune oophoritis.

Authors

S H Rhim, S E Millar, F Robey, A M Luo, Y H Lou, T Yule, P Allen, J Dean, K S Tung

×

Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 Total
Citations: 2 1 1 1 3 4 4 2 4 3 2 3 5 5 1 6 3 5 2 4 6 4 9 6 5 8 7 8 6 4 4 3 3 134
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2012 (5)

Title and authors Publication Year
Therapeutic effect of Bushen Huoxue Recipe (补肾活血方) on autoimmune premature ovarian failure mice established by immunization with recombinant porcine zona pellucida 4 antigen
C Tang, F Li, L Sun, D Li
Chinese Journal of Integrative Medicine 2012
Tolerogenic DNA Vaccine for Prevention of Autoimmune Ovarian Disease
Y Kang, G Zheng, A Chen, J Wang, Y Hu, J Li, J Zhang, W Gao, H Fu, G Xia, B Wang
Immunological Investigations 2012
The Effects of GM-CSF and IL-5 as Molecular Adjuvants on Immune Responses and Contraception Induced by mZP3 DNA Vaccination
X Ma, Z Kadir, J Li, F Zhang
American Journal of Reproductive Immunology 2012
Intranasal Co-delivery with the Mouse Zona Pellucida 3 and GM-CSF Expressing Constructs Enhances Humoral Immune Responses and Contraception in Mice
X Ma, J Li, F Zhang
Scandinavian Journal of Immunology 2012
Caveolin-1–Mediated Negative Signaling Plays a Critical Role in the Induction of Regulatory Dendritic Cells by DNA and Protein Coimmunization
J Li, S Geng, X Xie, H Liu, G Zheng, X Sun, G Zhao, Y Wan, Y Wu, X Chen, Y Zhong, B Wang
Journal of immunology (Baltimore, Md. : 1950) 2012

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 1 policy sources
Referenced in 14 patents
19 readers on Mendeley
See more details