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Citations to this article

Glutathione monoethyl ester ameliorates caerulein-induced pancreatitis in the mouse.
B A Neuschwander-Tetri, … , R J Sukhabote, J H Grendell
B A Neuschwander-Tetri, … , R J Sukhabote, J H Grendell
Published January 1, 1992
Citation Information: J Clin Invest. 1992;89(1):109-116. https://doi.org/10.1172/JCI115550.
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Research Article Article has an altmetric score of 3

Glutathione monoethyl ester ameliorates caerulein-induced pancreatitis in the mouse.

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Abstract

Studies in animal models suggest that oxygen radicals may be important in the pathogenesis of acute pancreatitis. Because glutathione is an essential component of the defense against radical-mediated cellular injury, we investigated whether pancreatic glutathione content is influenced by inducing acute pancreatitis and whether augmenting the intracellular supply of glutathione would alter the course of pancreatitis. Caerulein, a decapeptide cholecystokinin analogue, induces acute necrotizing pancreatitis in mice when given in high doses (50 micrograms/kg per h) over a period of 6 h. The pancreatic glutathione content (total, GSH + GSSG) in mice treated with high-dose caerulein fell to 17% of normal within 4 h of beginning caerulein and recovered toward normal after discontinuing caerulein treatment. Mice treated with glutathione monoethyl ester (20 mmol/kg 1 h before caerulein, 10 mmol/kg 3 and 7 h after starting caerulein) were found to have blunted depletion of pancreatic glutathione, diminished histologic evidence of pancreatitis (necrosis, inflammation, and vacuolization), and lower serum amylase values compared with mice treated with caerulein alone. These findings suggest that the profound depletion of pancreatic glutathione caused by hyperstimulation of the pancreas with caerulein is critically important in the pathogenesis of acute caerulein-induced pancreatitis.

Authors

B A Neuschwander-Tetri, L D Ferrell, R J Sukhabote, J H Grendell

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Year: 2021 2020 2018 2016 2015 2014 2013 2012 2011 2010 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1975 Total
Citations: 2 1 1 1 2 1 3 1 3 2 4 1 4 1 2 5 2 2 1 3 5 3 5 6 8 2 1 72
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Citations to this article in year 2013 (3)

Title and authors Publication Year
Free radicals and acute pancreatitis: Much ado about … something
D Closa
Free Radical Research 2013
Cerulein-Induced Acute Pancreatitis Is Associated With c-Jun NH(2)-Terminal Kinase 1–Dependent Ferritin Degradation and Iron-Dependent Free Radicals Formation:
M Sledzinski, A Borkowska, A Sielicka-Dudzin, M Halon, M Wozniak, JH Spodnik, AH Antosiewicz, J Antosiewicz
Pancreas 2013
Glutathione Ethyl Ester Supplementation during Pancreatic Islet Isolation Improves Viability and Transplant Outcomes in a Murine Marginal Islet Mass Model
AS Amaral, RL Pawlick, E Rodrigues, F Costal, A Pepper, FH Galvão, ML Correa-Giannella, AM Shapiro, A Nadal
PloS one 2013

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