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Citations to this article

A lymphocyte homing receptor (L-selectin) mediates the in vitro attachment of lymphocytes to myelinated tracts of the central nervous system.
K Huang, … , M S Singer, S D Rosen
K Huang, … , M S Singer, S D Rosen
Published November 1, 1991
Citation Information: J Clin Invest. 1991;88(5):1778-1783. https://doi.org/10.1172/JCI115498.
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Research Article Article has an altmetric score of 6

A lymphocyte homing receptor (L-selectin) mediates the in vitro attachment of lymphocytes to myelinated tracts of the central nervous system.

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Abstract

Lymphocytes enter lymph nodes by first adhering to high endothelial venules, an adhesive event mediated by a lectinlike lymphocyte receptor (L-selectin). Previously, it was shown with an in vitro assay that lymphocytes preferentially adhere to myelin-rich regions in brain sections. Here, using a recombinant form of L-selectin as an immunohistochemical reagent, we demonstrate potential ligands for L-selectin in myelinated regions of the central but not the peripheral nervous system. Using several antibodies and phorbol ester downmodulation of the receptor, we establish that L-selectin on human lymphocytes has a primary involvement in lymphocyte adherence to the myelinated regions. On mouse lymphocytes, the contribution of L-selectin appears to be partial. These findings raise the possibility that leukocyte targeting to myelin-rich regions, via a L-selectin dependent mechanism, may be a factor in the pathogenesis of certain central nervous system demyelinating diseases.

Authors

K Huang, J S Geoffroy, M S Singer, S D Rosen

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Total citations by year

Year: 2019 2018 2016 2014 2013 2012 2011 2008 2007 2004 2003 2001 1999 1998 1997 1995 1994 1993 1992 1983 Total
Citations: 1 1 1 1 1 1 1 1 2 1 1 2 1 2 4 5 10 7 3 1 47
Citation information
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Citations to this article (47)

Title and authors Publication Year
L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling
A Ivetic, HL Green, SJ Hart
Frontiers in immunology 2019
Early Targeting of L-Selectin on Leukocytes Promotes Recovery after Spinal Cord Injury, Implicating Novel Mechanisms of Pathogenesis
DA McCreedy, S Lee, CJ Sontag, P Weinstein, AD Olivas, AF Martinez, TM Fandel, A Trivedi, CA Lowell, SD Rosen, LJ Noble-Haeusslein
eNeuro 2018
Neuroimmune Interaction in the Regulation of Peripheral Opioid-Mediated Analgesia in Inflammation
S Hua
Frontiers in immunology 2016
Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis: Clinical immunology
K Göbel, MK Schuhmann, S Pankratz, D Stegner, AM Herrmann, A Braun, J Breuer, S Bittner, T Ruck, H Wiendl, C Kleinschnitz, B Nieswandt, SG Meuth
European Journal of Immunology 2014
Use of imaging to study leukocyte trafficking in the central nervous system
E Zenaro, B Rossi, S Angiari, G Constantin
Immunology and Cell Biology 2013
Diagnosis and Management of Neurolymphomatosis:
JM Baehring, TT Batchelor
The Cancer Journal 2012
The role of sulfoglucuronosyl glycosphingolipids in the pathogenesis of monoclonal IgM paraproteinemia and peripheral neuropathy
T Ariga
Proceedings of the Japan Academy. Series B, Physical and biological sciences 2011
L-Selectin-deficient SJL and C57BL/6 mice are not resistant to experimental autoimmune encephalomyelitis
C Uboldi, A Döring, C Alt, P Estess, M Siegelman, B Engelhardt
European Journal of Immunology 2008
Handbook of Neurochemistry and Molecular Neurobiology
VH Routh, JJ McArdle, NM Sanders, Z Song, R Wang
Handbook of Neurochemistry and Molecular Neurobiology 2007
Adhesion Molecules: Function and Inhibition
K Ley
2007
Ligands for L-Selectin: Homing, Inflammation, and Beyond
SD Rosen
Annual Review of Immunology 2004
Neurolymphomatosis
JM Baehring, D Damek, EC Martin, RA Betensky, FH Hochberg
Neuro-Oncology 2003
CD62L Is Required on Effector Cells for Local Interactions in the CNS to Cause Myelin Damage in Experimental Allergic Encephalomyelitis
IS Grewal, HG Foellmer, KD Grewal, H Wang, WP Lee, D Tumas, CA Janeway, RA Flavell
Immunity 2001
Theiler's virus-infected l-selectin-deficient mice have decreased infiltration of CD8+ T lymphocytes in central nervous system but clear the virus
X Zhang, L Brewer, B Walcheck, A Johnson, LR Pease, MK Njenga
Journal of Neuroimmunology 2001
Temporal kinetics and cellular phenotype of TNF p55/p75 receptors in experimental allergic encephalomyelitis
MA Kahn, JM Dopp, S Liva, AJ MacKenzie-Graham, R Chang, A Huang, R Nazarian, P Dell'Albani, D Condorelli, RR Voskuhl, J Vellis
Journal of Neuroimmunology 1999
Histochemistry and Cytochemistry of Endogenous Animal Lectins
Y Akimoto, H Hirano, Y Imai, J Hirabayashi, K Kasai
Progress in Histochemistry and Cytochemistry 1998
Soluble L-Selectin Increases in the Cerebrospinal Fluid Prior to Meningeal Involvement in Children with Acute Lymphoblastic Leukemia
A Daĝdemir, U Ertem, F Duru, Kirazli
Leukemia & Lymphoma 1998
Involvement of Selectins in Atherogenesis: A Primary or Secondary Event?
M Miyasaka, H Kawashima, R Korenaga, J Ando
Annals of the New York Academy of Sciences 1997
A sulfatide receptor distinct from L-selectin is involved in lymphocyte activation
Z Ding, H Kawashima, Y Suzuki, T Suzuki, PA Ward, M Miyasaka
FEBS Letters 1997
Advances in Molecular and Cell Biology
KJ Clemetson
Advances in Molecular and Cell Biology 1997
Quantitative assessment of myelin basic protein-reactive T cell entry to the central nervous system by using oligonucleotide probes complementary to VDJ junctional sequences of rat TCR beta-chain
D Sun, C Coleclough, L Cao, S Sun, J N Whitaker
Journal of Immunological Methods 1997
Cell adhesion molecule expression and homing of hematologic malignancies
W Timens
Critical Reviews in Oncology/Hematology 1995
Glycans and the modulation of neural-recognition molecule function
M Schachner, R Martini
Trends in Neurosciences 1995
Selective binding of peripheral blood lymphocytes to the walls of cerebral vessels in frozen sections of human brain
AJ Vora, ME Perry, C Hobbs, DC Dumonde, KA Brown
Journal of Immunological Methods 1995
Expression of sulfomucins in normal mucosae, colorectal adenocarcinomas, and metastases
Y Matsushita, N Yamamoto, H Shirahama, S Tanaka, S Yonezawa, T Yamori, T Irimura, E Sato
Japanese journal of cancer research : Gann 1995
Expression of sulfomucins in normal mucosae, colorectal adenocarcinomas, and metastases.
Matsushita Y, Yamamoto N, Shirahama H, Tanaka S, Yonezawa S, Yamori T, Irimura T, Sato E
Japanese journal of cancer research : Gann 1995
A spoonful of sugar to control inflammation?
E Tuomanen
Journal of Clinical Investigation 1994
Selectin ligands
A Varki
Proceedings of the National Academy of Sciences 1994
Glycosphingolipid antigens in cultured bovine brain microvascular endothelial cells: sulfoglucuronosyl paragloboside as a target of monoclonal IgM in demyelinative neuropathy [corrected]
T Kanda, H Yoshino, T Ariga, M Yamawaki, RK Yu
The Journal of Cell Biology 1994
Myelin localization of a central nervous system ligand for L-selectin
K Huang, A Kikuta, SD Rosen
Journal of Neuroimmunology 1994
Expression of ICAM-1, VCAM-1, L-selectin, and leukosialin in the mouse central nervous system during the induction and remission stages of experimental allergic encephalomyelitis
JM Dopp, SM Breneman, JA Olschowka
Journal of Neuroimmunology 1994
Selectins as potential targets of therapeutic intervention in inflammatory diseases
JK Welply, JL Keene, JJ Schmuke, SC Howard
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes 1994
Nervous tissue as an immune compartment: the dialect of the immune response in the CNS
Z Fabry, CS Raine, MN Hart
Immunology Today 1994
The Clinical Importance of Leucocyte and Endothelial Cell Adhesion Molecules in Inflammation
JC Mason, DO Haskard
1994
Glyco-and Cellbiology
F Wieland, W Reutter
1994
Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-alpha and interleukin-8 mRNA in human neutrophils. Evidence for a role of L-selectin as a signaling molecule
C Laudanna, G Constantin, P Baron, E Scarpini, G Scarlato, G Cabrini, C Dechecchi, F Rossi, MA Cassatella, G Berton
The Journal of biological chemistry 1994
Inflammatory disease: Where immunology and adhesion meet?
G Peltz
Current Opinion in Biotechnology 1993
Oligosaccharides that mediate mammalian cell-cell adhesion
T Feizi
Current Opinion in Structural Biology 1993
L-selectin and its biological ligands
SD Rosen
Histochemistry 1993
Ligands for l-selectin: where and how many?
SD Rosen
Research in Immunology 1993
Phenotype analysis of unstimulated lymphocytes and anti-cd3-stimulated proliferating t-cells from cerebrospinal fluid and peripheral blood in patients with multiple sclerosis and other neurological diseases
A Dufour, A Salmaggi, M Eoli, LL Mantia, C Milanese, A Nespolo
International Journal of Neuroscience 1993
Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion
PE Lipsky, R Rothlein, TK Kishimoto, RB Faanes, CW Smith
1993
Calcium-Dependent Heparin-Like Ligands For L-Selectin in Nonlymphoid Endothelial Cells
KE Norgard-Sumnicht, NM Varki, A Varki
Science 1993
Selectins and other mammalian sialic acid-binding lectins
A Varki
Current Opinion in Cell Biology 1992
High affinity binding of the leucocyte adhesion molecule L-selectin to 3′-sulphated-Lea and -Lex oligosaccharides and the predominance of sulphate in this interaction demonstrated by binding studies with a series of lipid-linked oligosaccharides
PJ Green, T Tamatani, T Watanabe, M Miyasaka, A Hasegawa, M Kiso, CT Yuen, MS Stoll, T Feizi
Biochemical and Biophysical Research Communications 1992
Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke
PM Kochanek, JM Hallenbeck
Stroke; a journal of cerebral circulation 1992
Progress in Brain Research
DE van Epps, L Saland, C Taylor, RC Williams
Progress in brain research 1983

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