This study examined the contribution of nitric oxide (NO) to the susceptibility or resistance to the hypertensive effects of high sodium chloride (8.0% NaCl) intake in young Dahl/Rapp salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) rats. Using NG-monomethyl-L-arginine (L-NMMA) as a probe for NO production in vivo, we found that increasing dietary sodium chloride increased NO activity in salt-resistant rats, but not in salt-sensitive rats. Exogenous L-arginine, the substrate for NO synthesis, decreased blood pressure to normotensive levels in salt-sensitive rats made hypertensive for 2 wk from 8.0% NaCl chow. D-arginine had no effect on blood pressure of these rats and L-arginine did not change blood pressure of salt-resistant rats. Intraperitoneal injections of L-arginine and its precursor, L-citrulline, and oral L-arginine, but not D-arginine, prevented the increase in blood pressure in salt-sensitive rats on the high salt chow over 2 wk of observation. In contrast, L-arginine did not alter the development of hypertension in spontaneously hypertensive rats. Mean urinary cGMP levels were higher in salt-sensitive rats on oral L-arginine than salt-sensitive rats on D-arginine. Infusion of L-NMMA acutely decreased, whereas intravenous L-arginine rapidly increased, urinary cGMP in both groups. L-arginine and L-citrulline increased production of NO and prevented salt-sensitive hypertension in Dahl/Rapp rats.
P Y Chen, P W Sanders
Title and authors | Publication | Year |
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Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction.
She H, Zheng J, Zhao G, Du Y, Tan L, Chen ZS, Wu Y, Li Y, Liu Y, Sun Y, Hu Y, Zuo D, Mao Q, Liu L, Li T |
Signal transduction and targeted therapy | 2025 |
Spontaneous vascular dysfunction in Dahl salt‐sensitive male rats raised without a high‐salt diet
Grano de Oro A, Kumariya S, Mell B, Zubcevic J, Joe B, Osman I |
Physiological Reports | 2024 |
Oxidative Stress in Kidney Injury and Hypertension
Arendshorst WJ, Vendrov AE, Kumar N, Ganesh SK, Madamanchi NR |
Antioxidants | 2024 |
MMP-9 regulates afferent arteriolar remodeling and function in hypertension-induced nephropathy
Wenguang Feng, Zhengrong Guan, Wei-Zhong Ying, Dongqi Xing, Kai Ying, Paul Sanders |
Kidney International | 2023 |
Common salt aggravated pathology of testosterone-induced benign prostatic hyperplasia in adult male Wistar rat.
Bello II, Omigbodun A, Morhason-Bello I |
BMC urology | 2023 |
Renal Epithelial Mitochondria: Implications for Hypertensive Kidney Disease
Stadler K, Ilatovskaya DV |
Comprehensive Physiology | 2023 |
Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension
J Wu, S Fang, K Lu, G Kumar, J Reho, D Brozoski, A Otanwa, C Hu, A Nair, K Wackman, L Agbor, J Grobe, C Sigmund |
2022 | |
Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension
T Kurtz, M Pravenec, S DiCarlo |
Clinical Science | 2022 |
Physiological, Pathological and Pharmacological Interactions of Hydrogen Sulphide and Nitric Oxide in the Myocardium of Rats with Left Ventricular Hypertrophy.
Ahmad A |
Current issues in molecular biology | 2022 |
Renal metabolism and hypertension
Z Tian, M Liang |
Nature Communications | 2021 |
β-Aminoisobutyric acid supplementation attenuated salt-sensitive hypertension in Dahl salt-sensitive rats through prevention of insufficient fumarase.
Zheng X, Zhou L, Jin Y, Zhao X, Ahmad H, OuYang Y, Chen S, Du J, Chen X, Chen L, Gao D, Yang Z, Tian Z |
Amino Acids | 2021 |
Symmetric Dimethylarginine is Altered in Patients After Myocardial Infarction and Predicts Adverse Outcomes
A Gąsecka, P Szwed, K Jasińska, O Fidali, A Kłębukowska, C Eyileten, M Postula, Ł Szarpak, T Mazurek, G Opolski, KJ Filipiak, M Ufnal |
Journal of inflammation research | 2021 |
No evidence of racial disparities in blood pressure salt sensitivity when potassium intake exceeds levels recommended in the US dietary guidelines
TW Kurtz, SE DiCarlo, M Pravenec, RC Morris |
American journal of physiology. Heart and circulatory physiology | 2021 |
l-Arginine Can Enhance the Beneficial Effect of Losartan in Patients with Chronic Aortic Regurgitation and Isolated Systolic Hypertension
SL Lin, M Lin, KL Wang, HW Kuo, T Tak |
International Journal of Angiology | 2021 |
L-phenylalanine attenuates high salt-induced hypertension in Dahl SS rats through activation of GCH1-BH4
Z Wang, C Cheng, X Yang, C Zhang, M Bader |
PloS one | 2021 |
Arginine and Endothelial Function
J Gambardella, W Khondkar, MB Morelli, X Wang, G Santulli, V Trimarco |
Biomedicines | 2020 |
Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension
MA Gilinsky, YK Polityko, AL Markel, TV Latysheva, AO Samson, B Polis, SE Naumenko |
BioMed Research International | 2020 |
Therapeutic Potential of Citrulline as an Arginine Supplement: A Clinical Pharmacology Review
J Rashid, SS Kumar, KM Job, X Liu, CD Fike, CM Sherwin |
Pediatric Drugs | 2020 |
Soluble guanylate cyclase stimulator praliciguat attenuates inflammation, fibrosis, and end-organ damage in the Dahl model of cardiorenal failure
CM Shea, GM Price, G Liu, R Sarno, ES Buys, MG Currie, JL Masferrer |
American journal of physiology. Renal physiology | 2020 |
NO Synthesis Markers Are Not Significantly Associated with Blood Pressure and Endothelial Dysfunction in Patients with Arterial Hypertension: A Cross-Sectional Study
O Malle, C Trummer, V Theiler-Schwetz, A Meinitzer, MH Keppel, MR Grübler, A Tomaschitz, J Voelkl, W März, S Pilz |
Journal of Clinical Medicine | 2020 |
Effects of intact and hydrolysed blue whiting proteins on blood pressure and markers of kidney function in obese Zucker fa/fa rats
A Drotningsvik, Å Oterhals, SA Mjøs, LA Vikøren, O Flesland, OA Gudbrandsen |
European Journal of Nutrition | 2020 |
Nitrite-stimulated Gastric Formation of S-nitrosothiols As An Antihypertensive Therapeutic Strategy
GH Oliveira-Paula, JE Tanus-Santos |
Current drug targets | 2019 |
Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension
A Gonzalez-Vicente, F Saez, CM Monzon, J Asirwatham, JL Garvin |
Physiological reviews | 2019 |
Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a role in renal microvascular pathophysiology in the Dahl salt-sensitive rat
W Feng, Z Guan, D Xing, X Li, W Ying, CE Remedies, EW Inscho, PW Sanders |
Kidney International | 2019 |
Fumarase Overexpression Abolishes Hypertension Attributable to endothelial NO synthase Haploinsufficiency in Dahl Salt-Sensitive Rats
H Xue, AM Geurts, K Usa, F Wang, Y Lin, J Phillips, L Henderson, MA Baker, Z Tian, M Liang |
Hypertension | 2019 |
Citrulline as a novel adjuvant candidate for vaccines
K KAMINAKA, J MATSUDA, C NOZAKI |
Biomedical Research | 2019 |
Small Amounts of Inorganic Nitrate or Beetroot Provide Substantial Protection From Salt-Induced Increases in Blood Pressure
RC Morris, M Pravenec, J Šilhavý, SE DiCarlo, TW Kurtz |
Hypertension | 2019 |
L-arginase induces vascular dysfunction in old spontaneously hypertensive rats
O Arishe, J McKenzie, F Priviero, A B Ebeigbe, R Clinton Webb |
Journal of African Association of Physiological Sciences | 2019 |
Nitric oxide production by glomerular podocytes
O Palygin, DV Ilatovskaya, V Levchenko, BT Endres, AM Geurts, A Staruschenko |
Nitric Oxide | 2018 |
Role of Nitric Oxide in the Cardiovascular and Renal Systems
A Ahmad, S Dempsey, Z Daneva, M Azam, N Li, PL Li, J Ritter |
International journal of molecular sciences | 2018 |
MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension
Y Liu, K Usa, F Wang, P Liu, AM Geurts, J Li, AM Williams, KR Regner, Y Kong, H Liu, J Nie, M Liang |
Journal of the American Society of Nephrology : JASN | 2018 |
Functional foods for augmenting nitric oxide activity and reducing the risk for salt-induced hypertension and cardiovascular disease in Japan
TW Kurtz, SE DiCarlo, M Pravenec, RC Morris |
Journal of Cardiology | 2018 |
Changing views on the common physiologic abnormality that mediates salt sensitivity and initiation of salt-induced hypertension: Japanese research underpinning the vasodysfunction theory of salt sensitivity
TW Kurtz, SE DiCarlo, M Pravenec, RC Morris |
Hypertension Research | 2018 |
Prehypertension and Cardiometabolic Syndrome
R Zimlichman, S Julius, G Mancia |
2018 | |
The potential of stimulating nitric oxide formation in the treatment of hypertension
LC Pinheiro, JE Tanus-Santos, MM Castro |
Expert Opinion on Therapeutic Targets | 2017 |
Novel Paradigms of Salt and Hypertension
W Feng, LJ DellItalia, PW Sanders |
Journal of the American Society of Nephrology : JASN | 2017 |
The American Heart Association Scientific Statement on salt sensitivity of blood pressure: Prompting consideration of alternative conceptual frameworks for the pathogenesis of salt sensitivity?
TW Kurtz, SE DiCarlo, M Pravenec, RC Morris |
Journal of Hypertension | 2017 |
REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles of the eNOS/NO/cGMP pathway and supplementation with L-arginine
J Jiang, Z Gan, Y Li, W Zhao, H Li, JP Zheng, Y Ke, C Zaragoza |
PloS one | 2017 |
Malate and Aspartate Increase L-Arginine and Nitric Oxide and Attenuate Hypertension
E Hou, N Sun, F Zhang, C Zhao, K Usa, M Liang, Z Tian |
Cell Reports | 2017 |
Cardioprotection and lifespan extension by the natural polyamine spermidine
T Eisenberg, M Abdellatif, S Schroeder, U Primessnig, S Stekovic, T Pendl, A Harger, J Schipke, A Zimmermann, A Schmidt, M Tong, C Ruckenstuhl, C Dammbrueck, AS Gross, V Herbst, C Magnes, G Trausinger, S Narath, A Meinitzer, Z Hu, A Kirsch, K Eller, D Carmona-Gutierrez, S Büttner, F Pietrocola, O Knittelfelder, E Schrepfer, P Rockenfeller, C Simonini, A Rahn, M Horsch, K Moreth, J Beckers, H Fuchs, V Gailus-Durner, F Neff, D Janik, B Rathkolb, J Rozman, MH de Angelis, T Moustafa, G Haemmerle, M Mayr, P Willeit, M Frieling-Salewsky, B Pieske, L Scorrano, T Pieber, R Pechlaner, J Willeit, SJ Sigrist, WA Linke, C Mühlfeld, J Sadoshima, J Dengjel, S Kiechl, G Kroemer, S Sedej, F Madeo |
Nature Medicine | 2016 |
Vasodysfunction That Involves Renal Vasodysfunction, Not Abnormally Increased Renal Retention of Sodium, Accounts for the Initiation of Salt-Induced HypertensionResponse to Morris et al
RC Morris, O Schmidlin, A Sebastian, M Tanaka, TW Kurtz |
Circulation | 2016 |
Salt-sensitive hypertension: mechanisms and effects of dietary and other lifestyle factors
L Pilic, CR Pedlar, Y Mavrommatis |
Nutrition Reviews | 2016 |
Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide inhibition but not glomerular hyperfiltration or hypertrophy
AJ Polichnowski, H Licea-Vargas, M Picken, J Long, R Bisla, GA Williamson, AK Bidani, KA Griffin |
American journal of physiology. Renal physiology | 2015 |
The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia
EE Gillis, JM Williams, MR Garrett, JN Mooney, JM Sasser |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2015 |
The Complex Relationship Between CKD and Ambulatory Blood Pressure Patterns
AD Sinha, R Agarwal |
Advances in Chronic Kidney Disease | 2015 |
Pediatric Nephrology
ED Avner, WE Harmon, P Niaudet, N Yoshikawa, F Emma, S Goldstein |
Pediatric Nephrology | 2015 |
Sodium and potassium regulate endothelial phospholipase C- and Bmx
WZ Ying, KJ Aaron, PW Sanders |
American journal of physiology. Renal physiology | 2014 |
Comprehensive Physiology
SN Cheuvront, RW Kenefick |
Comprehensive Physiology | 2014 |
The role of the kidney and the sympathetic nervous system in hypertension
P Thomas, I Dasgupta |
Pediatric Nephrology | 2014 |
Exogenous L-arginine attenuates the effects of angiotensin II on renal hemodynamics and the pressure natriuresis-diuresis relationship
S Das, DL Mattson |
Clinical and Experimental Pharmacology and Physiology | 2014 |
Resveratrol Increases Nitric Oxide Production in the Rat Thick Ascending Limb via Ca2+/Calmodulin
A Gonzalez-Vicente, PD Cabral, JL Garvin, JM Sands |
PloS one | 2014 |
Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension
JM Sasser, MW Cunningham, C Baylis |
American journal of physiology. Renal physiology | 2014 |
Dietary Management of Diabetic Chronic Kidney Disease
D Beeharry, F Joseph, D Ewins, S Nair |
Current Nutrition Reports | 2014 |
FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats
YT Ghebremariam, K Yamada, JC Lee, CL Johnson, D Atzler, M Anderssohn, R Agrawal, JP Higgins, AJ Patterson, RH Böger, JP Cooke |
PloS one | 2013 |
Dietary potassium: a key mediator of the cardiovascular response to dietary sodium chloride
M Kanbay, Y Bayram, Y Solak, PW Sanders |
Journal of the American Society of Hypertension | 2013 |
Nutritional Management of Renal Disease
A Molfino, BR Don, GA Kaysen |
Nutritional Management of Renal Disease | 2013 |
Seldin and Giebisch's The Kidney
CJ Cooper, LD Dworkin, WL Henrich |
Seldin and Giebisch's The Kidney | 2013 |
Effects of exercise training on nitric oxide synthase in the kidney of spontaneously hypertensive rats
D Ito, O Ito, P Cao, N Mori, C Suda, Y Muroya, K Takashima, S Ito, M Kohzuki |
Clinical and Experimental Pharmacology and Physiology | 2013 |
eLS
YC Chang, YH Yu, LM Chuang |
Encyclopedia of Life Sciences | 2013 |
L-Homoarginine and L-arginine are antagonistically related to blood pressure in an elderly population: the Hoorn study
LP van der Zwan, M Davids, PG Scheffer, JM Dekker, CD Stehouwer, T Teerlink |
Journal of Hypertension | 2013 |
Salt, Salt Sensitivity, and the Endothelium: A Pathway to Discovery of Molecular Mechanisms
R Agarwal |
Hypertension | 2013 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2012 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2012 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2012 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2012 |
Effect of Dietary Salt on Regulation of TGF-β in the Kidney
MB Hovater, PW Sanders |
Seminars in Nephrology | 2012 |
Long-term blood pressure control: is there a set-point in the brain?
Y Nishida, M Tandai-Hiruma, T Kemuriyama, K Hagisawa |
The Journal of Physiological Sciences | 2012 |
Renal Medullary Circulation
TL Pallone, A Edwards, DL Mattson |
Comprehensive Physiology | 2012 |
Encyclopedia of Inorganic and Bioinorganic Chemistry
RD Sandlin, HM Carrell, DW Wright |
Encyclopedia of Inorganic and Bioinorganic Chemistry | 2012 |
Nutrition, Lifestyle Factors, and Blood Pressure
E Miller, S Juraschek |
Nutrition, Lifestyle Factors, and Blood Pressure | 2012 |
Age-Dependent Salt Hypertension in Dahl Rats: Fifty Years of Research
J Zicha, Z Dobešová, M Vokurková, H Rauchová, S Hojná, M Kadlecová, M Behuliak, I Vaněčková, J Kuneš |
Physiological research / Academia Scientiarum Bohemoslovaca | 2012 |
Oxidative Stress and Disease
I Paur, M Carlsen, B Halvorsen, R Blomhoff |
Herbal Medicine | 2011 |
Mechanisms and consequences of salt sensitivity and dietary salt intake
M Kanbay, Y Chen, Y Solak, PW Sanders |
Current Opinion in Nephrology and Hypertension | 2011 |
Regulation of Renal NaCl Transport by Nitric Oxide, Endothelin, and ATP: Clinical Implications
JL Garvin, M Herrera, PA Ortiz |
Annual Review of Physiology | 2011 |
Role of l-arginine uptake mechanisms in renal blood flow responses to angiotensin II in rats
NW Rajapakse, DL Mattson |
Acta Physiologica | 2011 |
Propionyl-L-carnitine, L-arginine and niacin in sexual medicine: a nutraceutical approach for erectile dysfunction : A nutraceutical approach for erectile dysfunction
D Gianfrilli, R Lauretta, CD Dato, C Graziadio, C Pozza, JD Larichaudy, E Giannetta, AM Isidori, A Lenzi |
Andrologia | 2011 |
Statins reverse renal inflammation and endothelial dysfunction induced by chronic high salt intake
MC Fiore, PM Jimenez, D Cremonezzi, LI Juncos, NH García |
American journal of physiology. Renal physiology | 2011 |
Soluble Guanylate Cyclase Stimulation Prevents Fibrotic Tissue Remodeling and Improves Survival in Salt-Sensitive Dahl Rats
S Geschka, A Kretschmer, Y Sharkovska, OV Evgenov, B Lawrenz, A Hucke, B Hocher, JP Stasch, MA Deli |
PloS one | 2011 |
Natural Antioxidants and Hypertension: Promise and Challenges
TJ Kizhakekuttu, ME Widlansky |
Cardiovascular Therapeutics | 2010 |
Vascular dysfunction in retinopathy-an emerging role for arginase
RB Caldwell, W Zhang, MJ Romero, RW Caldwell |
Brain Research Bulletin | 2010 |
Regulation of circadian blood pressure: from mice to astronauts
R Agarwal |
Current Opinion in Nephrology and Hypertension | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Vascular consequences of dietary salt intake
PW Sanders |
American journal of physiology. Renal physiology | 2009 |
Increased Serum Nitric Oxide Concentration After Bariatric Surgery—A Potential Mechanism for Cardiovascular Benefit
T Sledzinski, M Sledzinski, RT Smolenski, J Swierczynski |
Obesity Surgery | 2009 |
The effect of salt on renal damage in eNOS-deficient mice
G Daumerie, LK Bridges, S Yancey, W Davis, P Huang, J Loscalzo, MA Pointer |
Hypertension Research | 2009 |
ROLE OF l-ARGININE IN NITRIC OXIDE PRODUCTION IN HEALTH AND HYPERTENSION
NW Rajapakse, DL Mattson |
Clinical and Experimental Pharmacology and Physiology | 2009 |
Renal functional, not morphological, abnormalities account for salt sensitivity in Dahl rats
WM Manger, S Simchon, MB Stokes, JJ Reidy, AR Kumar, L Baer, G Gallo, FJ Haddy |
Journal of Hypertension | 2009 |
Systemic hypertension in two patients with ASL deficiency: a result of nitric oxide deficiency?
N Brunetti-Pierri, A Erez, O Shchelochkov, W Craigen, B Lee |
Molecular Genetics and Metabolism | 2009 |
Nutritional Cosmetics
J Varani |
Nutritional Cosmetics | 2009 |
Vascular consequences of dietary salt intake
PW Sanders |
American journal of physiology. Renal physiology | 2009 |
Inhibition of natriuretic factors increases blood pressure in rats
AA Banday, MF Lokhandwala |
American journal of physiology. Renal physiology | 2009 |
Salt Inactivates Endothelial Nitric Oxide Synthase in Endothelial Cells
J Li, J White, L Guo, X Zhao, J Wang, EJ Smart, XA Li |
The Journal of nutrition | 2009 |
Dietary Salt Activates an Endothelial Proline-Rich Tyrosine Kinase 2/c-Src/Phosphatidylinositol 3-Kinase Complex to Promote Endothelial Nitric Oxide Synthase Phosphorylation
WZ Ying, K Aaron, PW Sanders |
Hypertension | 2008 |
Redox Control of Renal Function and Hypertension
R Nistala, A Whaley-Connell, JR Sowers |
Antioxidants & Redox Signaling | 2008 |
Regression of left ventricular hypertrophy and aortic remodelling in NO-deficient hypertensive rats: effect of l-arginine and spironolactone
L Paulis, J Matuskova, M Adamcova, V Pelouch, J Simko, K Krajcirovicova, A Potacova, I Hulin, P Janega, O Pechanova, F Simko |
Acta Physiologica | 2008 |
Microcirculation
K Ley |
Microcirculation | 2008 |
Targeting Reactive Oxygen Species in Hypertension
C Delles, WH Miller, AF Dominiczak |
Antioxidants & Redox Signaling | 2008 |
The antihypertensive effect of arginine
S Vasdev, V Gill |
International Journal of Angiology | 2008 |
Exogenous l -Arginine Ameliorates Angiotensin II-Induced Hypertension and Renal Damage in Rats
NW Rajapakse, CD Miguel, S Das, DL Mattson |
Hypertension | 2008 |
Antihypertensive agents and arterial stiffness: relevance to reducing cardiovascular risk in the chronic kidney disease patient
R Agarwal |
Current Opinion in Internal Medicine | 2007 |
Effects of lifestyle changes and metformin on salt sensitivity and nitric oxide metabolism in obese salt-sensitive Hispanics
IS Hoffmann, AB Alfieri, LX Cubeddu |
Journal of Human Hypertension | 2007 |
Sodium in Health and Disease
P Manunta, M Sciarrone |
Sodium in Health and Disease: The Example of Nonsteroidal Anti-inflammatory Agents | 2007 |
Phosphorylation of Neuronal and Endothelial Nitric Oxide Synthase in the Kidney with High and Low Salt Diets
PF Mount, SA Fraser, Y Watanabe, N Lane, F Katsis, ZP Chen, BE Kemp, DA Power |
Nephron Physiology | 2006 |
Therapeutic Use of Citrulline in Cardiovascular Disease
MJ Romero, DH Platt, RB Caldwell, RW Caldwell |
Cardiovascular Drug Reviews | 2006 |
Nitric oxide in the kidney: functions and regulation of synthesis
PF Mount, DA Power |
Acta Physiologica | 2006 |
AMINO ACIDS, ARGINASE AND NITRIC OXIDE IN VASCULAR HEALTH
NN Huynh, J Chin-Dusting |
Clinical and Experimental Pharmacology and Physiology | 2006 |
Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample
CS Fox, MG Larson, SJ Hwang, EP Leip, N Rifai, D Levy, EJ Benjamin, JM Murabito, JB Meigs, RS Vasan |
Kidney International | 2006 |
Hypertension in renal parenchymal disease: Why is it so resistant to treatment?
VM Campese, N Mitra, D Sandee |
Kidney International | 2006 |
An In-Depth Review of the Evidence Linking Dietary Salt Intake and Progression of Chronic Kidney Disease
C Jones-Burton, SI Mishra, JC Fink, J Brown, W Gossa, GL Bakris, MR Weir |
American Journal of Nephrology | 2006 |
Amino acids as modulators of endothelium-derived nitric oxide
M Kakoki, HS Kim, CJ Edgell, N Maeda, O Smithies, DL Mattson |
American journal of physiology. Renal physiology | 2006 |
A Missing Link Between a High Salt Intake and Blood Pressure Increase
M Katori, M Majima |
Journal of Pharmacological Sciences | 2006 |
The Vascular Endothelium II
S Moncada, A Higgs |
2006 | |
Does dietary salt increase the risk for progression of kidney disease?
SI Mishra, C Jones-Burton, JC Fink, J Brown, GL Bakris, MR Weir |
Current Hypertension Reports | 2005 |
l-Arginine fails to protect against myocardial remodelling in l-NAME-induced hypertension
F Simko, I Luptak, J Matuskova, K Krajcirovicova, Z Sumbalova, J Kucharska, A Gvozdjakova, J Simko, P Babal, O Pechanova, I Bernatova |
European Journal of Clinical Investigation | 2005 |
Low-Renin (Volume Dependent) Mild-Hypertensive Patients Have Impaired Flow-Mediated and Glyceryl-Trinitrate Stimulated Vascular Reactivity
JC Yugar-Toledo, LH Tácito, SE Ferreira-Melo, W Sousa, F Consolin-Colombo, MC Irigoyen, K Franchini, OR Coelho, H Moreno |
Circulation Journal | 2005 |
Increased number of aldosterone-sensitive NTS neurons in Dahl salt-sensitive rats
JC Geerling, SM Sequeira, AD Loewy |
Brain Research | 2005 |
CNS-induced natriuresis, neurohypophyseal peptides and renal dopamine and noradrenaline excretion in prehypertensive salt-sensitive Dahl rats: CNS-induced natriuresis and oxytocin in Dahl-S
M Sjöquist, SL Lee, P Hansell |
Experimental Physiology | 2005 |
Links Between Dietary Salt Intake, Renal Salt Handling, Blood Pressure, and Cardiovascular Diseases
P Meneton, X Jeunemaitre, HE de Wardener, GA Macgregor |
Physiological reviews | 2005 |
Mechanism of hypertensive nephropathy in the Dahl/Rapp rat: a primary disorder of vascular smooth muscle
PX Wang, PW Sanders |
American journal of physiology. Renal physiology | 2005 |
Enhanced expression of EGF receptor in a model of salt-sensitive hypertension
WZ Ying, PW Sanders |
American journal of physiology. Renal physiology | 2005 |
Heme oxygenase-derived carbon monoxide promotes arteriolar endothelial dysfunction and contributes to salt-induced hypertension in Dahl salt-sensitive rats
FJ Teran, RA Johnson, BK Stevenson, KJ Peyton, KE Jackson, SD Appleton, W Durante, FK Johnson |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2005 |
Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertension
FK Johnson, RA Johnson, KJ Peyton, W Durante |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2005 |
Blunted Response of the Renin-Angiotensin System and Nitric Oxide Synthesis Related to Sodium Sensitivity in Immunoglobulin A Nephropathy
Y KONISHI, T MORIKAWA, T YASU, K TERAMOTO, N OKADA, K YOSHIOKA, M OKUMURA, M IMANISHI |
Hypertension Research | 2004 |
Chronic l-arginine treatment reduces vascular smooth muscle cell hypertrophy through cell cycle modifications in spontaneously hypertensive rats
B Somoza, C González, V Cachofeiro, V Lahera, MS Fernández-Alfonso |
Journal of Hypertension | 2004 |
Tissue kallikrein attenuates salt-induced renal fibrosis by inhibition of oxidative stress
JJ Zhang, G Bledsoe, K Kato, L Chao, J Chao |
Kidney International | 2004 |
Is there a link between salt-intake and atrial natriuretic peptide system during hypertension induced by nitric oxide blockade?
LM Alves, LR Tosi, J Antunes-Rodrigues, EC Cárnio |
Regulatory Peptides | 2004 |
Influence of dietary NaCl on L-arginine transport in the renal medulla
T Zewde, F Wu, DL Mattson |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2004 |
l -Arginine uptake affects nitric oxide production and blood flow in the renal medulla
M Kakoki, HS Kim, WJ Arendshorst, DL Mattson |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2004 |
Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics
IS Hoffmann, R Tavares-Mordwinkin, AM Castejon, AB Alfieri, LX Cubeddu |
Journal of Human Hypertension | 2004 |
Identification of salt-sensitive genes in the kidneys of Dahl rats:
GK Lighthall, BP Hamilton, JM Hamlyn |
Journal of Hypertension | 2004 |
L-Arginine and Hypertension
N Gokce |
The Journal of nutrition | 2004 |
Role of L-Arginine in the Pathogenesis and Treatment of Renal Disease
G Cherla, EA Jaimes |
The Journal of nutrition | 2004 |
Prevention of Hypertension and Renal Dysfunction in Dahl Rats by α-Tocopherol
P Forde, AW Scribner, R Dial, J Loscalzo, MR Trolliet |
Journal of Cardiovascular Pharmacology | 2003 |
Coronary Artery Disease
Y Okura, K Hayashi, T Shingu, Y Kuga, S Nomura, G Kajiyama, Y Nakashima, K Saku |
Coronary Artery Disease | 2003 |
Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway
FI Achike, CY Kwan |
Clinical and Experimental Pharmacology and Physiology | 2003 |
Nitric oxide production decreases after salt loading but is not related to blood pressure changes or nitric oxide-mediated vascular responses
V Dishy, GG Sofowora, H Imamura, Y Nishimi, HG Xie, AJ Wood, CM Stein |
Journal of Hypertension | 2003 |
Salt-loading and nitric oxide inhibition after the menopause
MH Tayebjee, KW Lee, GY Lip |
Journal of Hypertension | 2003 |
Nitric oxide inhibition as a mechanism for blood pressure increase during salt loading in normotensive postmenopausal women
A Scuteri, MC Stuehlinger, JP Cooke, JG Wright, EG Lakatta, DE Anderson, JL Fleg |
Journal of Hypertension | 2003 |
NO mediates antifibrotic actions of l-arginine supplementation following induction of anti-thy1 glomerulonephritis
H Peters, U Daig, S Martini, M Ruckert, F Schaper, L Liefeldt, S Kramer, HH Neumayer |
Kidney International | 2003 |
L-Arginine supplementation accelerates renal fibrosis and shortens life span in experimental lupus nephritis
H Peters, WA Border, M Rückert, S Krämer, HH Neumayer, NA Noble |
Kidney International | 2003 |
Accelerated ubiquitination and proteasome degradation of a genetic variant of inducible nitric oxide synthase
WZ Ying, PW Sanders |
Biochemical Journal | 2003 |
Tempol, an antioxidant, restores endothelium-derived hyperpolarizing factor-mediated vasodilation during hypertension
AS Adeagbo, IG Joshua, C Falkner, PJ Matheson |
European Journal of Pharmacology | 2003 |
A high-fat, refined-carbohydrate diet affects renal NO synthase protein expression and salt sensitivity
CK Roberts, ND Vaziri, RK Sindhu, RJ Barnard |
Journal of applied physiology | 2003 |
The interrelationship between TGF-β 1 and nitric oxide is altered in salt-sensitive hypertension
WZ Ying, PW Sanders |
American journal of physiology. Renal physiology | 2003 |
Mechanisms of salt-sensitive hypertension: role of renal medullary inducible nitric oxide synthase
N Tian, AW Gannon, RA Khalil, RD Manning |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2003 |
Arginase inhibition slows the progression of renal failure in rats with renal ablation
M Sabbatini, A Pisani, F Uccello, G Fuiano, R Alfieri, A Cesaro, B Cianciaruso, VE Andreucci |
American journal of physiology. Renal physiology | 2003 |
Heme Oxygenase Inhibitor Restores Arteriolar Nitric Oxide Function in Dahl Rats
FK Johnson, W Durante, KJ Peyton, RA Johnson |
Hypertension | 2003 |
Salt-induced hypertension in WKY rats: prevention by alpha-lipoic acid supplementation
Sudesh Vasdev, Vicki Gill, Linda Longerich, Sushil Parai, Veeresh Gadag |
Molecular and Cellular Biochemistry | 2003 |
Beneficial effect of enalapril in spontaneously hypertensive rats cardiac remodeling with nitric oxide synthesis blockade
RL Zorzi, LM Pereira, CA Mandarim-de-Lacerda |
Journal of Cellular and Molecular Medicine | 2002 |
Protective role of endothelial nitric oxide synthase
EW Albrecht, CA Stegeman, P Heeringa, RH Henning, H Goor |
The Journal of Pathology | 2002 |
Insulin resistance, a new target for nitric oxide-delivery drugs
S Cook, U Scherrer |
Fundamental and Clinical Pharmacology | 2002 |
The nitric oxide system in glucocorticoid-induced hypertension
JA Whitworth, CG Schyvens, Y Zhang, MC Andrews, GJ Mangos, JJ Kelly |
Journal of Hypertension | 2002 |
REGULATION OFNITRICOXIDESYNTHESIS BYDIETARYFACTORS
G Wu, CJ Meininger |
Annual Review of Nutrition | 2002 |
Blunted acetylcholine relaxation and nitric oxide release in arteries from renal hypertensive rats
E Stankevicius, AC Martinez, MJ Mulvany, U Simonsen |
Journal of Hypertension | 2002 |
Sex-specific acute effect of estrogen on endothelium-derived contracting factor in the renal artery of hypertensive Dahl rats
L Zhang, H Kosaka |
Journal of Hypertension | 2002 |
Salt Intake, Endothelial Dysfunction, and Salt-Sensitive Hypertension
E Bragulat, A la Sierra |
The Journal of Clinical Hypertension | 2002 |
Renal segmental tubular response to salt during the normal menstrual cycle
A Pechere-Bertschi, M Maillard, H Stalder, HR Brunner, M Burnier |
Kidney International | 2002 |
Decreased Expression of Arginase II in the Kidneys of Dahl Salt-Sensitive Rats
S IWATA, T TSUJINO, Y IKEDA, T ISHIDA, T UEYAMA, T GOTOH, M MORI, M YOKOYAMA |
Hypertension Research | 2002 |
The presence of African American race predicts improvement in coronary endothelial function after supplementary L-arginine
JL Houghton, EF Philbin, DS Strogatz, MT Torosoff, SA Fein, PA Kuhner, VE Smith, AA Carr |
Journal of the American College of Cardiology | 2002 |
Activation of the Fas/Fas ligand pathway in hypertensive renal disease in Dahl/Rapp rats
PW Sanders, PX Wang |
BMC Nephrology | 2002 |
Magnesium influx enhanced by nitric oxide in hypertensive rat proximal tubule cells
A Ikari, T Kano, Y Suketa |
Biochemical and Biophysical Research Communications | 2002 |
Subtle Acquired Renal Injury as a Mechanism of Salt-Sensitive Hypertension
RJ Johnson, J Herrera-Acosta, GF Schreiner, B Rodríguez-Iturbe |
New England Journal of Medicine | 2002 |
R EGULATION OF N ITRIC O XIDE S YNTHESIS BY D IETARY F ACTORS
G Wu, CJ Meininger |
Annual Review of Nutrition | 2002 |
Efecto de la ingesta de sal sobre la función endotelial y su relación con el fenómeno de la sensibilidad a la sal en la hipertensión arterial esencial
EB Baur, MT Rebollo, ML Morellón, AS la Iserte |
Hipertensión y Riesgo Vascular | 2002 |
Increased dietary salt activates rat aortic endothelium
WZ Ying, PW Sanders |
Hypertension | 2002 |
1A-779 attenuates angiotensin-(1–7) depressor response in salt-induced hypertensive rats
MA Bayorh, D Eatman, M Walton, RR Socci, M Thierry-Palmer, N Emmett |
Peptides | 2002 |
Renal medullary nitric oxide deficit of Dahl S rats enhances hypertensive actions of angiotensin II
M Szentiványi, AP Zou, DL Mattson, P Soares, C Moreno, RJ Roman, AW Cowley |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2002 |
Arginine intake, blood pressure, and the incidence of acute coronary events in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
B Venho, S Voutilainen, VP Valkonen, J Virtanen, TA Lakka, TH Rissanen, ML Ovaskainen, M Laitinen, JT Salonen |
The American journal of clinical nutrition | 2002 |
Salt intake, endothelial dysfunction, and salt-sensitive hypertension.
Bragulat E, de la Sierra A |
Journal of clinical hypertension (Greenwich, Conn.) | 2002 |
Therapeutic modification of the l-arginine-eNOS pathway in cardiovascular diseases
G Goumas, C Tentolouris, D Tousoulis, C Stefanadis, P Toutouzas |
Atherosclerosis | 2001 |
Sodium Chloride Loading Does Not Alter Endothelium-Dependent Vasodilation of Forearm Vasculature in Either Salt-Sensitive or Salt-Resistant Patients with Essential Hypertension
Y HIGASHI, S SASAKI, K NAKAGAWA, M KIMURA, K NOMA, S SASAKI, K HARA, H MATSUURA, K CHAYAMA, T OSHIMA |
Hypertension Research | 2001 |
Differential nNOS gene expression in salt-sensitive and salt-resistant Dahl rats
H Castrop, A Kurtz |
Journal of Hypertension | 2001 |
Relative deficiency of nitric oxide-dependent vasodilation in salt-hypertensive Dahl rats: the possible role of superoxide anions
J Zicha, Z Dobešová, J Kuneš |
Journal of Hypertension | 2001 |
Increased dietary salt accelerates chronic allograft nephropathy in rats
PW Sanders, CL Gibbs, KM Akhi, LA Macmillan-Crow, KR Zinn, YF Chen, CJ Young, JA Thompson |
Kidney International | 2001 |
Dimethylarginines in chronic renal failure
N Wahbi, RN Dalton, C Turner, M Denton, I Abbs, R Swaminathan |
Journal of clinical pathology | 2001 |
Effects of aging and alterations in dietary sodium intake on total nitric oxide production
RJ Schmidt, WH Beierwaltes, C Baylis |
American journal of kidney diseases : the official journal of the National Kidney Foundation | 2001 |
Decreased renal expression of nitric oxide synthase isoforms in adrenocorticotropin-induced and corticosterone-induced hypertension
YK Lou, C Wen, M Li, DJ Adams, MX Wang, F Yang, BJ Morris, JA Whitworth |
Hypertension | 2001 |
Nitric oxide synthase (NOS2) mutation in Dahl/Rapp rats decreases enzyme stability
WZ Ying, H Xia, PW Sanders |
Circulation research | 2001 |
Salt-Sensitive Hypertension and Inducible Nitric Oxide Synthase: Form-Function Dichotomy of a Coding Region Mutation, Mutatis Mutandis
J Loscalzo |
Circulation research | 2001 |
Endothelial Dysfunction in Salt-Sensitive Essential Hypertension
E Bragulat, A de la Sierra, MT Antonio, A Coca |
Hypertension | 2001 |
Intrarenal Transport and Vasoactive Substances in Hypertension
PA Ortiz, JL Garvin |
Hypertension | 2001 |
Induction of apoptosis during development of hypertensive nephrosclerosis1
WZ Ying, PX Wang, PW Sanders |
Kidney International | 2000 |
Abnormal pressure-natriuresis in hypertension: role of nitric oxide
Granger, Alexander |
Acta Physiologica Scandinavica | 2000 |
Effects of sodium intake on the pressor and renal responses to nitric oxide synthesis inhibition in normotensive individuals with different sodium sensitivity
G Barba, PJ Vallance, P Strazzullo, RJ MacAllister |
Journal of Hypertension | 2000 |
Overexpression of chloride channel CLC-K2 mRNA in the renal medulla of Dahl salt-sensitive rats
H Castrop, BK Krämer, GA Riegger, A Kurtz, K Wolf |
Journal of Hypertension | 2000 |
Renal cyclic 3′,5′-guanosine monophosphate and sodium excretion in Dahl salt-resistant and Dahl salt-sensitive rats
LJ Millatt, HM Siragy |
Journal of Hypertension | 2000 |
Tubulointerstitial injury and loss of nitric oxide synthases parallel the development of hypertension in the Dahl-SS Rat
RJ Johnson, KL Gordon, C Giachelli, T Kurth, MM Skelton, AW Cowley |
Journal of Hypertension | 2000 |
Role Of Nitric Oxide In Adrenocorticotrophin-Induced Hypertension: L-Arginine Effects Reversed By N-Nitro- L-Arginine
C Wen, M Li, JA Whitworth |
Clinical and Experimental Pharmacology and Physiology | 2000 |
Increased Endothelium-Monocyte Interactions in Salt-Sensitive Hypertension: Effect of L-Arginine
C Artigues, V Richard, C Roussel, F Lallemand, JP Henry, C Thuillez |
Journal of Cardiovascular Pharmacology | 2000 |
Control of arterial blood pressure and renal sodium excretion by nitric oxide synthase in the renal medulla
Mattson, Wu |
Acta Physiologica Scandinavica | 2000 |
Effect of Oral L-Arginine Administration for Three Weeks in Two Kidney-two Clip Hypertensive Rats
IJ de la Riva, MI Rosón, GW Vega, N Speziale, LE Albornoz, EL Palumbo, AJ Ferrero, PF Damiano |
Archives Of Physiology And Biochemistry | 2000 |
Potassium augments vascular relaxation mediated by nitric oxide in the carotid arteries of hypertensive Dahl rats
MS Zhou, H Kosaka, H Yoneyama |
American Journal of Hypertension | 2000 |
Blood pressure and metabolic changes during dietary L-arginine supplementation in humans
A Siani, E Pagano, R Iacone, L Iacoviello, F Scopacasa, P Strazzullo |
American Journal of Hypertension | 2000 |
Nitric oxide and salt sensitivity
LX Cubeddu, AB Alfieri, IS Hoffmann, E Jimenez, CM Roa, R Cubeddu, C Palermo, RM Baldonedo |
American Journal of Hypertension | 2000 |
Effects of NO donors and synthase agonists on endothelial cell uptake of l -Arg and superoxide production
AA Ogonowski, WH Kaesemeyer, L Jin, V Ganapathy, FH Leibach, RW Caldwell |
American journal of physiology. Cell physiology | 2000 |
l -Arginine increases nitric oxide production in isolated lungs of chronically hypoxic newborn pigs
CD Fike, MR Kaplowitz, LA Rehorst-Paea, LD Nelin |
Journal of applied physiology | 2000 |
Characterization of l -arginine transporters in rat renal inner medullary collecting duct
F Wu, B Cholewa, DL Mattson |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2000 |
Mechanisms of salt-sensitive hypertension: role of inducible nitric oxide synthase
DY Tan, S Meng, GW Cason, RD Manning |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2000 |
Interaction Between Nitric Oxide and Mineralocorticoids in the Long-Term Control of Blood Pressure
G Alvarez, A Osuna, R Wangensteen, F Vargas |
Hypertension | 2000 |
Study on the Relationship Between Plasma Nitrite and Nitrate Level and Salt Sensitivity in Human Hypertension: Modulation of Nitric Oxide Synthesis by Salt Intake
N Fujiwara, T Osanai, T Kamada, T Katoh, K Takahashi, K Okumura |
Circulation | 2000 |
Subpressor Dose of L-NAME Unmasks Hypertensive Effect of Chronic Hyperinsulinemia
M Bursztyn, J Mekler, E Peleg, J Bernheim |
Hypertension | 2000 |
Renal Structural Properties in Prehypertensive Dahl Salt-Sensitive Rats
F Tomoda, M Takata, H Kinuno, S Tomita, K Yasumoto, H Inoue |
Hypertension | 2000 |
Nitric Oxide and the Regulation of the Peripheral Circulation
PJ Kadowitz, DB McNamara |
2000 | |
Role of Female Sex Hormones in the Development and Reversal of Dahl Hypertension
C Hinojosa-Laborde, DL Lange, JR Haywood |
Hypertension | 2000 |
Textbook of Angiology
JB Chang |
2000 | |
Dysfunctional Renal Nitric Oxide Synthase as a Determinant of Salt-Sensitive Hypertension: Mechanisms of Renal Artery Endothelial Dysfunction and Role of Endothelin for Vascular Hypertrophy and Glomerulosclerosis
M Barton, I Vos, S Shaw, P Boer, LI D'uscio, HJ Gröne, TJ Rabelink, T Lattmann, P Moreau, TF Lüscher |
Journal of the American Society of Nephrology : JASN | 2000 |
L-arginine attenuates endothelial dysfunction in endotoxin-induced lung injury
BC Sheridan, RC Mclntyre, DR Meldrum, DA Fullerton |
Surgery | 1999 |
Salt sensitivity and cardiovascular risk
A Bataineh, L Raij |
Current Opinion in Nephrology and Hypertension | 1999 |
Hypertension, nitric oxide and end-organ damage
A Ishani, L Raij |
Current Opinion in Nephrology and Hypertension | 1999 |
Neural mechanisms in nitric-oxide-deficient hypertension
M Sander, RG Victor |
Current Opinion in Nephrology and Hypertension | 1999 |
A Mechanism of Oxygen Free Radical Production in the Dahl Hypertensive Rat
A Swei, F Lacy, FA Delano, DA Parks, GW Schmid-Schönbein |
Microcirculation | 1999 |
Coenzyme Q versus hypertension: does CoQ decrease endothelial superoxide generation?
MF McCarty |
Medical Hypotheses | 1999 |
Enhanced Nitric Oxide Synthesis Reverses Salt-Induced Alterations in Blood Flow and Cgmp Levels
MA Bayorh, E Williams, M Thierry-Palmer, G Sanford, N Emmett, S Harris-Hooker, RR Socci, TC Chu |
Clinical and Experimental Hypertension | 1999 |
Potassium Supplementation Increases Sodium Excretion and Nitric Oxide Production in Hypertensive Dahl Rats
MS Zhou, Y Nishida, H Yoneyama, QH Chen, H Kosaka |
Clinical and Experimental Hypertension | 1999 |
Human NK cells express endothelial nitric oxide synthase, and nitric oxide protects them from activation-induced cell death by regulating expression of TNF-alpha
K Shen, FA DeLano, BW Zweifach, GW Schmid-Schönbein |
Journal of immunology (Baltimore, Md. : 1950) | 1999 |
Dietary salt increases endothelial nitric oxide synthase and TGF-β1 in rat aortic endothelium
WZ Ying, PW Sanders |
American journal of physiology. Heart and circulatory physiology | 1999 |
Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition
MA Rudd, M Trolliet, S Hope, AW Scribner, G Daumerie, G Toolan, T Cloutier, J Loscalzo |
American journal of physiology. Heart and circulatory physiology | 1999 |
Nitric oxide synthase in the JGA of the SHR: expression and role in tubuloglomerular feedback
WJ Welch, A Tojo, JU Lee, DG Kang, CG Schnackenberg, CS Wilcox |
American journal of physiology. Renal physiology | 1999 |
Ontogenetic Aspects of Hypertension Development: Analysis in the Rat
J Zicha, J Kuneš |
Physiological reviews | 1999 |
Role of nitric oxide in the early renal hemodynamic response after unilateral nephrectomy
JM Valdivielso, F Pérez-Barriocanal, J García-Estañ, JM López-Novoa |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 1999 |
Role of Neuronal Nitric Oxide Synthase in Dahl Salt-Sensitive Hypertension
DY Tan, S Meng, RD Manning |
Hypertension | 1999 |
Handling 22 NaCl by the Blood-Brain Barrier and Kidney: Its Relevance to Salt-Induced Hypertension in Dahl Rats
S Simchon, W Manger, E Golanov, J Kamen, G Sommer, CH Marshall |
Hypertension | 1999 |
Renal Intramedullary Infusion of l -Arginine Prevents Reduction of Medullary Blood Flow and Hypertension in Dahl Salt-Sensitive Rats
N Miyata, AW Cowley |
Hypertension | 1999 |
Nitric Oxide–Induced Inhibition of Transport by Thick Ascending Limbs From Dahl Salt-Sensitive Rats
NH García, CF Plato, BA Stoos, JL Garvin |
Hypertension | 1999 |
Nitric Oxide Synthase Isotype Expression in Salt-Sensitive and Salt-Resistant Dahl Rats
Z Ni, F Oveisi, ND Vaziri |
Hypertension | 1999 |
A Large Blood Pressure–Raising Effect of Nitric Oxide Synthase Inhibition in Humans
M Sander, B Chavoshan, RG Victor |
Hypertension | 1999 |
Different Frequencies of Inducible Nitric Oxide Synthase Genotypes in Older Hypertensives
CL Glenn, WY Wang, BJ Morris |
Hypertension | 1999 |
Salt intake determines the renal response to L-arginine infusion in normal human subjects
YM Barri, CS Wilcox |
Kidney International | 1998 |
Dietary salt regulates expression of Tamm-Horsfall glycoprotein in rats
WZ Ying, PW Sanders |
Kidney International | 1998 |
Is the nitric oxide system involved in genetic hypertension in Dahl rats?
AY Deng |
Kidney International | 1998 |
Role of nitric oxide in vascular hyper-responsiveness to norepinephrine in hypertensive Dahl rats
Y Nishida, J Ding, MS Zhou, QH Chen, H Murakami, XZ Wu, H Kosaka |
Journal of Hypertension | 1998 |
Hypertension
P Hamet, Z Pausova, V Adarichev, K Adaricheva, J Tremblay |
Journal of Hypertension | 1998 |
Isoform-specific regulation of nitric oxide synthase mRNA in the kidney by sodium and blood pressure
S Nadaud, C Mao, G Luvàra, JB Michel, F Soubrier |
Journal of Hypertension | 1998 |
ROLE OF NITRIC OXIDE IN THE DEVELOPMENT OF CORTICOTROPIN-INDUCED HYPERTENSION IN SHEEP
JJ Tresham, CN May |
Clinical and Experimental Pharmacology and Physiology | 1998 |
Possible Mechanisms of Salt-Induced Hypertension in Dahl Salt-Sensitive Rats
MA Bayorh, EC Ogbolu, E Williams, M Thierry-Palmer, G Sanford, N Emmett, S Harris-Hooker, RR Socci, TC Chu, VM Chenault |
Physiology & Behavior | 1998 |
Chronic nitric oxide inhibition model six years on
R Zatz, C Baylis |
Hypertension | 1998 |
Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats
TK Gupta, M Toruner, MK Chung, RJ Groszmann |
Hepatology | 1998 |
Genetic mapping of soluble guanylyl cyclase genes: implications for linkage to blood pressure in the Dahl rat
M Azam, G Gupta, W Chen, S Wellington, D Warburton, RS Danziger |
Hypertension | 1998 |
Nitric oxide deficiency, leukocyte activation, and resultant ischemia are crucial to the pathogenesis of diabetic retinopathy/ neuropathy — preventive potential of antioxidants, essential fatty acids, chromium, ginkgolides, and pentoxifylline
MF McCarty |
Medical Hypotheses | 1998 |
Studies of Arginine Metabolism and Salt Sensitivity in the Dahl/Rapp Rat Models of Hypertension
PA Wood, DA Hamm, PY Chen, PW Sanders |
Molecular Genetics and Metabolism | 1998 |
Inverse Relationship of Urinary Cyclic GMP to Blood Pressure Reactivity in the CARDIA Study: Vasodilatory Regulation of Sympathetic Vasoconstriction
JH Markovitz, D Tucker, CE Lewis, PW Sanders, DG Warnock |
Psychosomatic medicine | 1998 |
Dietary salt enhances glomerular endothelial nitric oxide synthase through TGF-β1
WZ Ying, PW Sanders |
American journal of physiology. Renal physiology | 1998 |
l -Arginine prevents lung neutrophil accumulation and preserves pulmonary endothelial function after endotoxin
BC Sheridan, RC McIntyre, DR Meldrum, DA Fullerton |
American journal of physiology. Lung cellular and molecular physiology | 1998 |
The Utility of Nitric Oxide in the Postoperative Period
SC Body, SK Shernan |
Seminars in cardiothoracic and vascular anesthesia | 1998 |
Dietary salt modulates renal production of transforming growth factor-β in rats
WZ Ying, PW Sanders |
American journal of physiology. Renal physiology | 1998 |
Renal medullary interstitial infusion of l -arginine prevents hypertension in Dahl salt-sensitive rats
N Miyata, AP Zou, DL Mattson, AW Cowley |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 1998 |
Candidate Genes in the Regulation of Na + Transport by Inner Medullary Collecting Duct Cells From Dahl Rats
RF Husted, JP Rapp, JB Stokes |
Hypertension | 1998 |
Vascular Smooth Muscle Nitric Oxide Synthase Anomalies in Dahl/Rapp Salt-Sensitive Rats
PY Chen, RD Gladish, PW Sanders |
Hypertension | 1998 |
Inducible Nitric Oxide Synthase and Blood Pressure
DL Mattson, CY Maeda, TD Bachman, AW Cowley |
Hypertension | 1998 |
Enhanced Depressor Response to Nitric Oxide in the Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats
S Kagiyama, T Tsuchihashi, I Abe, M Fujishima |
Hypertension | 1998 |
Induction of P4504A Activity Improves Pressure-Natriuresis in Dahl S Rats
M Alonso-Galicia, B Frohlich, RJ Roman |
Hypertension | 1998 |
Concordant Genetic and Physiological Data Are Required for Candidate Genes
JP Rapp |
Hypertension | 1998 |
Hypertension and the Insulin Resistance Syndrome of Rats
I Klimeš, E Šeböková |
Annals of the New York Academy of Sciences | 1997 |
Relationship of diastolic blood pressure with cyclic GMP excretion among young adults (the CARDIA study)
JH Markovitz, CE Lewis, PW Sanders, D Tucker, DG Warnock |
Journal of Hypertension | 1997 |
NITRIC OXIDE, THE KIDNEY AND HYPERTENSION
C Schnackenberg, AR Patel, KA Kirchner, JP Granger |
Clinical and Experimental Pharmacology and Physiology | 1997 |
Ming Li, Tafline Fraser, Jian Wang* and Judith A Whitworth
J Whitworth |
Clinical and Experimental Pharmacology and Physiology | 1997 |
ROLE OF NITRIC OXIDE IN TUBULOGLOMERULAR FEEDBACK: EFFECTS OF DIETARY SALT
WJ Welch, CS Wilcox |
Clinical and Experimental Pharmacology and Physiology | 1997 |
EFFECT OF DIETARY SALT LOADING AND HIGH-CALCIUM DIET ON VASCULAR SMOOTH MUSCLE RESPONSES AND ENDOTHELIUM FUNCTION IN RATS
BJ Adegunloye, OA Sofola |
Clinical and Experimental Pharmacology and Physiology | 1997 |
Hypertension and the Insulin Resistance Syndrome of Rats.: Are They Related?
I Klimeš, E Šeböková |
Annals of the New York Academy of Sciences | 1997 |
Nitric oxide in renal health and disease
BC Kone |
American Journal of Kidney Diseases | 1997 |
Changes of the plasma endothelin in adaptation to increased salt intake in rats
H S Oh, K Yoo, M Kim, K C Choi, J U Lee |
The Korean Journal of Internal Medicine | 1997 |
L-Arginine Decreases Alveolar Macrophage Proinflammatory Monokine Production during Acute Lung Injury by a Nitric Oxide Synthase-Dependent Mechanism:
DR Meldrum, RC McIntyre, BC Sheridan, JC Cleveland, DA Fullerton, AH Harken |
The Journal of Trauma: Injury, Infection and Critical Care | 1997 |
Nitric Oxide Synthase and Renin-Angiotensin System Gene Expression in Salt-Sensitive and Salt-Resistant Sabra Rats
A Lippoldt, V Gross, K Schneider, A Hansson, S Nadaud, W Schneider, M Bader, C Yagil, Y Yagil, FC Luft |
Hypertension | 1997 |
Regional Renal Nitric Oxide Release in Stroke-Prone Spontaneously Hypertensive Rats
A Zuckerman, PN Chander, GA Zeballos, CT Stier |
Hypertension | 1997 |
Prolonged Reduction of High Blood Pressure With Human Nitric Oxide Synthase Gene Delivery
KF Lin, L Chao, J Chao |
Hypertension | 1997 |
Oxidative Stress in the Dahl Hypertensive Rat
A Swei, F Lacy, FA DeLano, GW Schmid-Schönbein |
Hypertension | 1997 |
Relationship Between Insulin Resistance and Endothelium-Dependent Vascular Relaxation in Patients With Essential Hypertension
Y Higashi, T Oshima, N Sasaki, N Ishioka, Y Nakano, R Ozono, M Yoshimura, K Ishibashi, H Matsuura, G Kajiyama |
Hypertension | 1997 |
Prolonged Administration of l -Arginine Ameliorates Chronic Pulmonary Hypertension and Pulmonary Vascular Remodeling in Rats
Y Mitani, K Maruyama, M Sakurai |
Circulation | 1997 |
Hypertension and the Heart
A Zanchetti, RB Devereux, L Hansson, S Gorini |
1997 | |
Asymmetrical Dimethylarginine, an Endogenous Nitric Oxide Synthase Inhibitor, in Experimental Hypertension
H Matsuoka, S Itoh, M Kimoto, K Kohno, O Tamai, Y Wada, H Yasukawa, G Iwami, S Okuda, T Imaizumi |
Hypertension | 1997 |
Effects of Chronic Nitric Oxide Synthase Inhibition on Cerebral Arterioles in Rats
JM Chillon, S Ghoneim, GL Baumbach |
Hypertension | 1997 |
Nitric Oxide and the Kidney
MS Goligorsky, SS Gross |
1997 | |
Endothelial Function in Hypertension
D Webb, P Vallance |
1997 | |
Primary renal abnormalities in hereditary hypertension
RG Woolfson, HE de Wardener |
Kidney International | 1996 |
Salt-sensitive hypertension: Lessons from animal models1
PW Sanders |
American Journal of Kidney Diseases | 1996 |
Localized administration of sodium nitroprusside enhances its protection against platelet aggregation in stenosed and injured coronary arteries
JT Willerson, SR Igo, SK Yao, JC Ober, MP Macris, JJ Ferguson |
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital | 1996 |
Pathophysiology of the vascular wall: the role of nitric oxide in renal disease
L Raij, E Jaimes, D Castillo, J Guerra, G Westberg |
Prostaglandins Leukotrienes and Essential Fatty Acids | 1996 |
Nitric Oxide and Renal Regulation of Sodium Excretion
FJ Salazar |
Endothelium : journal of endothelial cell research | 1996 |
Coordinate changes of renin and brain-type nitric-oxide-synthase (b-NOS) mRNA levels in rat kidneys
K Schricker, B Pötzl, M Hamann, A Kurtz |
Pflügers Archiv - European Journal of Physiology | 1996 |
Lipopolysaccharide and Tumor Necrosis Factor Stimulate Lung Microvascular Arginine Uptake, a Response Attenuated by Dexamethasone
M Pan, M Wasa, U Ryan, W Souba |
JPEN. Journal of parenteral and enteral nutrition | 1996 |
Chronic l -Arginine Administration Attenuates Cardiac Hypertrophy in Spontaneously Hypertensive Rats
H Matsuoka, M Nakata, K Kohno, Y Koga, G Nomura, H Toshima, T Imaizumi |
Hypertension | 1996 |
Salt Intake and Plasma Atrial Natriuretic Peptide and Nitric Oxide in Hypertension
VM Campese, M Tawadrous, R Bigazzi, S Bianchi, AS Mann, S Oparil, L Raij |
Hypertension | 1996 |
Impaired Renal Vasodilation and Urinary cGMP Excretion in Dahl Salt-Sensitive Rats
S Simchon, W Manger, G Blumberg, J Brensilver, S Cortell |
Hypertension | 1996 |
Nitric Oxide and the Regulation of Blood Pressure in the Hypertension-Prone and Hypertension-Resistant Sabra Rat
D Rees, D Ben-Ishay, S Moncada |
Hypertension | 1996 |
l -Arginine Restores Dilator Responses of the Basilar Artery to Acetylcholine During Chronic Hypertension
T Kitazono, FM Faraci, DD Heistad |
Hypertension | 1996 |
Effect of Salt Intake and Inhibitor Dose on Arterial Hypertension and Renal Injury Induced by Chronic Nitric Oxide Blockade
SS Yamada, AL Sassaki, CK Fujihara, DM Malheiros, GD Nucci, R Zatz |
Hypertension | 1996 |
l -Arginine Prevents Corticotropin-Induced Increases in Blood Pressure in the Rat
SW Turner, C Wen, M Li, JA Whitworth |
Hypertension | 1996 |
Renal Response to l -Arginine in Salt-Sensitive Patients With Essential Hypertension
Y Higashi, T Oshima, M Watanabe, H Matsuura, G Kajiyama |
Hypertension | 1996 |
Role of 20-HETE in Elevating Loop Chloride Reabsorption in Dahl SS/Jr Rats
AP Zou, HA Drummond, RJ Roman |
Hypertension | 1996 |
Blunted Pressure Natriuresis in Ovariectomized Dahl-Iwai Salt-Sensitive Rats
K Otsuka, H Suzuki, T Sasaki, N Ishii, H Itoh, T Saruta |
Hypertension | 1996 |
Nitric oxide
AJ Farrell, DR Blake |
Annals of the rheumatic diseases | 1996 |
Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat
AY Deng, JP Rapp |
Journal of Clinical Investigation | 1995 |
Glomerular actions of nitric oxide
L Raij, C Baylis |
Kidney International | 1995 |
Dietary L-Arginine Attenuates Blood Pressure in Mineralocorticoid-Salt Hypertensive Rats
P Laurant, B Demolombe, A Berthelot |
Clinical and Experimental Hypertension | 1995 |
Clinical biology of nitric oxide
MG Davies, GJ Fulton, PO Hagen |
British Journal of Surgery | 1995 |
Nitric Oxide
RA Schroeder, PC Kuo |
Anesthesia & Analgesia | 1995 |
Hypertension Is Not Related to Suppressed Lymphocyte Proliferation but to Elevated NO Synthesis in Vascular Smooth Muscle Cells of Borderline Hypertensive Rat
J Xiao, PK Pang |
Blood Pressure | 1995 |
The emerging multifaceted roles of nitric oxide
PC Kuo, RA Schroeder |
Annals of Surgery | 1995 |
L-arginine may mediate the therapeutic effects of low protein diets
I Narita, WA Border, M Ketteler, E Ruoslahti, NA Noble |
Proceedings of the National Academy of Sciences | 1995 |
Nitric Oxide: Physiology and Pharmacology
RA Schroeder, PC Kuo |
Anesthesia & Analgesia | 1995 |
Lack of Evidence for Linkage of the Endothelial Cell Nitric Oxide Synthase Gene to Essential Hypertension
A Bonnardeaux, S Nadaud, A Charru, X Jeunemaitre, P Corvol, F Soubrier |
Circulation | 1995 |
Renal Vasodilation With l -Arginine: Effects of Dietary Salt
X Deng, WJ Welch, CS Wilcox |
Hypertension | 1995 |
Nitric Oxide Synthase Isoform Activities in Kidney of Dahl Salt-Sensitive Rats
Y Ikeda, K Saito, JI Kim, M Yokoyama |
Hypertension | 1995 |
Effects of l -Arginine Infusion on Renal Hemodynamics in Patients With Mild Essential Hypertension
Y Higashi, T Oshima, R Ozono, M Watanabe, H Matsuura, G Kajiyama |
Hypertension | 1995 |
Stimulation of Endogenous Nitric Oxide Pathway by l -Arginine Reduces Declamp Mortality and Attenuates Hypertension Associated With Aortic Cross-Clamp–Induced Hindlimb Ischemia in Rats
JS Jin, LG DAlecy |
Hypertension | 1995 |
Dietary Sodium Intake Modulates Vasodilation Mediated by Nitroprusside But Not by Methacholine in the Human Forearm
CM Stein, R Nelson, M Brown, M Wood, AJ Wood |
Hypertension | 1995 |
Nitric Oxide and Its Putative Role in Hypertension
AF Dominiczak, DF Bohr |
Hypertension | 1995 |
Role of Nitric Oxide in Sepsis and ADRS
MP Fink, D Payen |
1995 | |
Beyond ACE inhibition: new developments in drug therapy for hypertension
LM Burrell, CI Johnston |
The Medical Journal of Australia | 1995 |
Endogenous nitric oxide synthesis determines sensitivity to the pressor effect of salt
JP Tolins, PJ Shultz |
Kidney International | 1994 |
Functional versus structural changes in the pathophysiology of acute ischemic renal failure in aging rats
M Sabbatini, G Sansone, F Uccello, LD Nicola, A Giliberti, V Sepe, P Magri, G Conte, VE Andreucci |
Kidney International | 1994 |
Cellular Biology of Glomerulosclerosis
EN Wardie |
Renal Failure | 1994 |
Physiological and pathophysiological roles of nitric oxide
AG Stewart, LH Phan, G Grigoriadis |
Microsurgery | 1994 |
Renal vasoconstriction during inhibition of NO synthase: Effects of dietary salt
X Deng, WJ Welch, CS Wilcox |
Kidney International | 1994 |
L-arginine decreases the infiltration of the kidney by macrophages in obstructive nephropathy and puromycin-induced nephrosis
AA Reyes, BH Porras, FI Chasalow, S Klahr |
Kidney International | 1994 |
Nitric Oxide in the Kidney: Synthesis, Localization, and Function
S Bachmann, P Mundel |
American Journal of Kidney Diseases | 1994 |
Salt sensitivity in hypertension. Renal and cardiovascular implications
VM Campese |
Hypertension | 1994 |
New perspectives in hypertension research. Potentials of vascular biology
VJ Dzau, GH Gibbons, R Morishita, RE Pratt |
Hypertension | 1994 |
Vascular responsiveness to nitric oxide synthesis inhibition in hypertensive rats
ML Pucci, KB Miller, LB Dick, H Guan, L Lin, A Nasjletti |
Hypertension | 1994 |
Long-term administration of L-arginine improves nitric oxide release from kidney in deoxycorticosterone acetate-salt hypertensive rats
H Hayakawa, Y Hirata, E Suzuki, K Kimura, K Kikuchi, T Nagano, M Hirobe, M Omata |
Hypertension | 1994 |
Renal apical membrane sodium-hydrogen exchange in genetic salt-sensitive hypertension
JL Lewis, DG Warnock |
Hypertension | 1994 |
Brain nitric oxide synthase activity in normal, hypertensive, and stroke-prone rats
N Clavier, JR Tobin, JR Kirsch, M Izuta, RJ Traystman |
Stroke; a journal of cerebral circulation | 1994 |
Beneficial Circulatory Effect of L-Arginine
T Nakaki, R Kato |
The Japanese Journal of Pharmacology | 1994 |
Adaptation to increased dietary salt intake in the rat. Role of endogenous nitric oxide
PJ Shultz, JP Tolins |
Journal of Clinical Investigation | 1993 |
Renal acid excretion and intracellular pH in salt-sensitive genetic hypertension
DC Batlle, AM Sharma, MW Alsheikha, M Sobrero, A Saleh, C Gutterman |
Journal of Clinical Investigation | 1993 |
Arginine feeding modifies cyclosporine nephrotoxicity in rats
LD Nicola, SC Thomson, LM Wead, MR Brown, FB Gabbai |
Journal of Clinical Investigation | 1993 |
Clonidine, but not bradykinin or ANP, inhibits Na+ and water transport in Dahl SS rat CCD
CT Hawk, JA Schafer |
Kidney International | 1993 |
Nitric oxide mediates renal vasodilation during erythropoietin-induced polycythemia
CS Wilcox, X Deng, AH Doll, H Snellen, WJ Welch |
Kidney International | 1993 |
The L-Arginine-Nitric Oxide Pathway
FH Epstein, S Moncada, A Higgs |
New England Journal of Medicine | 1993 |
Endothelial Activation and the Kidney: Vasomediator Modulation and Antioxidant Strategies
GM Vercellotti, JP Tolins |
American Journal of Kidney Diseases | 1993 |
Effect of L-Arginine Treatment in Pregnant Rats with Adriamycin Nephropathy
E Podjarny, A Pomeranz, M Rathaus, J Green, O Gonen, R Shamir, J Bernheim |
Hypertension in Pregnancy | 1993 |
Pregnancy restores the renal vasodilator response to glycine in Dahl salt-sensitive rats
SA Whitescarver, CM Heesch |
Hypertension | 1993 |
L-arginine administration normalizes pressure natriuresis in hypertensive Dahl rats
A Patel, S Layne, D Watts, KA Kirchner |
Hypertension | 1993 |
Essential hypertension: a renal disease? A review and update of the evidence
RG Luke |
Hypertension | 1993 |
Role of nitric oxide synthesis in salt-sensitive hypertension in Dahl/Rapp rats
PY Chen, PW Sanders |
Hypertension | 1993 |
L-arginine in the clinical arena: tool or remedy?
TF Lüscher, WE Haefeli |
Circulation | 1993 |
Salt-induced increase in arterial pressure during nitric oxide synthesis inhibition
FJ Salazar, A Alberola, JM Pinilla, JC Romero, T Quesada |
Hypertension | 1993 |
Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage
C Baylis, B Mitruka, A Deng |
Journal of Clinical Investigation | 1992 |
INHIBITION OF NO SYNTHESIS HAS AN ADDITIVE EFFECT ON HYPERTENSION INDUCED BY ACTH IN CONSCIOUS RATS
M Li, GJ Dusting, JA Whitworth |
Clinical and Experimental Pharmacology and Physiology | 1992 |
Nitric oxide synthase in macula densa regulates glomerular capillary pressure
CS Wilcox, WJ Welch, F Murad, SS Gross, G Taylor, R Levi, HH Schmidt |
Proceedings of the National Academy of Sciences | 1992 |