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Citations to this article

L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats.
P Y Chen, P W Sanders
P Y Chen, P W Sanders
Published November 1, 1991
Citation Information: J Clin Invest. 1991;88(5):1559-1567. https://doi.org/10.1172/JCI115467.
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L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats.

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Abstract

This study examined the contribution of nitric oxide (NO) to the susceptibility or resistance to the hypertensive effects of high sodium chloride (8.0% NaCl) intake in young Dahl/Rapp salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) rats. Using NG-monomethyl-L-arginine (L-NMMA) as a probe for NO production in vivo, we found that increasing dietary sodium chloride increased NO activity in salt-resistant rats, but not in salt-sensitive rats. Exogenous L-arginine, the substrate for NO synthesis, decreased blood pressure to normotensive levels in salt-sensitive rats made hypertensive for 2 wk from 8.0% NaCl chow. D-arginine had no effect on blood pressure of these rats and L-arginine did not change blood pressure of salt-resistant rats. Intraperitoneal injections of L-arginine and its precursor, L-citrulline, and oral L-arginine, but not D-arginine, prevented the increase in blood pressure in salt-sensitive rats on the high salt chow over 2 wk of observation. In contrast, L-arginine did not alter the development of hypertension in spontaneously hypertensive rats. Mean urinary cGMP levels were higher in salt-sensitive rats on oral L-arginine than salt-sensitive rats on D-arginine. Infusion of L-NMMA acutely decreased, whereas intravenous L-arginine rapidly increased, urinary cGMP in both groups. L-arginine and L-citrulline increased production of NO and prevented salt-sensitive hypertension in Dahl/Rapp rats.

Authors

P Y Chen, P W Sanders

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M Kakoki, HS Kim, WJ Arendshorst, DL Mattson
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2004
Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics
IS Hoffmann, R Tavares-Mordwinkin, AM Castejon, AB Alfieri, LX Cubeddu
Journal of Human Hypertension 2004
Identification of salt-sensitive genes in the kidneys of Dahl rats:
GK Lighthall, BP Hamilton, JM Hamlyn
Journal of Hypertension 2004
L-Arginine and Hypertension
N Gokce
The Journal of nutrition 2004
Role of L-Arginine in the Pathogenesis and Treatment of Renal Disease
G Cherla, EA Jaimes
The Journal of nutrition 2004
Prevention of Hypertension and Renal Dysfunction in Dahl Rats by α-Tocopherol
P Forde, AW Scribner, R Dial, J Loscalzo, MR Trolliet
Journal of Cardiovascular Pharmacology 2003
Coronary Artery Disease
Y Okura, K Hayashi, T Shingu, Y Kuga, S Nomura, G Kajiyama, Y Nakashima, K Saku
Coronary Artery Disease 2003
Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway
FI Achike, CY Kwan
Clinical and Experimental Pharmacology and Physiology 2003
Nitric oxide production decreases after salt loading but is not related to blood pressure changes or nitric oxide-mediated vascular responses
V Dishy, GG Sofowora, H Imamura, Y Nishimi, HG Xie, AJ Wood, CM Stein
Journal of Hypertension 2003
Salt-loading and nitric oxide inhibition after the menopause
MH Tayebjee, KW Lee, GY Lip
Journal of Hypertension 2003
Nitric oxide inhibition as a mechanism for blood pressure increase during salt loading in normotensive postmenopausal women
A Scuteri, MC Stuehlinger, JP Cooke, JG Wright, EG Lakatta, DE Anderson, JL Fleg
Journal of Hypertension 2003
NO mediates antifibrotic actions of l-arginine supplementation following induction of anti-thy1 glomerulonephritis
H Peters, U Daig, S Martini, M Ruckert, F Schaper, L Liefeldt, S Kramer, HH Neumayer
Kidney International 2003
L-Arginine supplementation accelerates renal fibrosis and shortens life span in experimental lupus nephritis
H Peters, WA Border, M Rückert, S Krämer, HH Neumayer, NA Noble
Kidney International 2003
Accelerated ubiquitination and proteasome degradation of a genetic variant of inducible nitric oxide synthase
WZ Ying, PW Sanders
Biochemical Journal 2003
Tempol, an antioxidant, restores endothelium-derived hyperpolarizing factor-mediated vasodilation during hypertension
AS Adeagbo, IG Joshua, C Falkner, PJ Matheson
European Journal of Pharmacology 2003
A high-fat, refined-carbohydrate diet affects renal NO synthase protein expression and salt sensitivity
CK Roberts, ND Vaziri, RK Sindhu, RJ Barnard
Journal of applied physiology 2003
The interrelationship between TGF-β 1 and nitric oxide is altered in salt-sensitive hypertension
WZ Ying, PW Sanders
American journal of physiology. Renal physiology 2003
Mechanisms of salt-sensitive hypertension: role of renal medullary inducible nitric oxide synthase
N Tian, AW Gannon, RA Khalil, RD Manning
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2003
Arginase inhibition slows the progression of renal failure in rats with renal ablation
M Sabbatini, A Pisani, F Uccello, G Fuiano, R Alfieri, A Cesaro, B Cianciaruso, VE Andreucci
American journal of physiology. Renal physiology 2003
Heme Oxygenase Inhibitor Restores Arteriolar Nitric Oxide Function in Dahl Rats
FK Johnson, W Durante, KJ Peyton, RA Johnson
Hypertension 2003
Salt-induced hypertension in WKY rats: prevention by alpha-lipoic acid supplementation
Sudesh Vasdev, Vicki Gill, Linda Longerich, Sushil Parai, Veeresh Gadag
Molecular and Cellular Biochemistry 2003
Beneficial effect of enalapril in spontaneously hypertensive rats cardiac remodeling with nitric oxide synthesis blockade
RL Zorzi, LM Pereira, CA Mandarim-de-Lacerda
Journal of Cellular and Molecular Medicine 2002
Protective role of endothelial nitric oxide synthase
EW Albrecht, CA Stegeman, P Heeringa, RH Henning, H Goor
The Journal of Pathology 2002
Insulin resistance, a new target for nitric oxide-delivery drugs
S Cook, U Scherrer
Fundamental and Clinical Pharmacology 2002
The nitric oxide system in glucocorticoid-induced hypertension
JA Whitworth, CG Schyvens, Y Zhang, MC Andrews, GJ Mangos, JJ Kelly
Journal of Hypertension 2002
REGULATION OFNITRICOXIDESYNTHESIS BYDIETARYFACTORS
G Wu, CJ Meininger
Annual Review of Nutrition 2002
Blunted acetylcholine relaxation and nitric oxide release in arteries from renal hypertensive rats
E Stankevicius, AC Martinez, MJ Mulvany, U Simonsen
Journal of Hypertension 2002
Sex-specific acute effect of estrogen on endothelium-derived contracting factor in the renal artery of hypertensive Dahl rats
L Zhang, H Kosaka
Journal of Hypertension 2002
Salt Intake, Endothelial Dysfunction, and Salt-Sensitive Hypertension
E Bragulat, A la Sierra
The Journal of Clinical Hypertension 2002
Renal segmental tubular response to salt during the normal menstrual cycle
A Pechere-Bertschi, M Maillard, H Stalder, HR Brunner, M Burnier
Kidney International 2002
Decreased Expression of Arginase II in the Kidneys of Dahl Salt-Sensitive Rats
S IWATA, T TSUJINO, Y IKEDA, T ISHIDA, T UEYAMA, T GOTOH, M MORI, M YOKOYAMA
Hypertension Research 2002
The presence of African American race predicts improvement in coronary endothelial function after supplementary L-arginine
JL Houghton, EF Philbin, DS Strogatz, MT Torosoff, SA Fein, PA Kuhner, VE Smith, AA Carr
Journal of the American College of Cardiology 2002
Activation of the Fas/Fas ligand pathway in hypertensive renal disease in Dahl/Rapp rats
PW Sanders, PX Wang
BMC Nephrology 2002
Magnesium influx enhanced by nitric oxide in hypertensive rat proximal tubule cells
A Ikari, T Kano, Y Suketa
Biochemical and Biophysical Research Communications 2002
Subtle Acquired Renal Injury as a Mechanism of Salt-Sensitive Hypertension
RJ Johnson, J Herrera-Acosta, GF Schreiner, B Rodríguez-Iturbe
New England Journal of Medicine 2002
R EGULATION OF N ITRIC O XIDE S YNTHESIS BY D IETARY F ACTORS
G Wu, CJ Meininger
Annual Review of Nutrition 2002
Efecto de la ingesta de sal sobre la función endotelial y su relación con el fenómeno de la sensibilidad a la sal en la hipertensión arterial esencial
EB Baur, MT Rebollo, ML Morellón, AS la Iserte
Hipertensión y Riesgo Vascular 2002
Increased dietary salt activates rat aortic endothelium
WZ Ying, PW Sanders
Hypertension 2002
1A-779 attenuates angiotensin-(1–7) depressor response in salt-induced hypertensive rats
MA Bayorh, D Eatman, M Walton, RR Socci, M Thierry-Palmer, N Emmett
Peptides 2002
Renal medullary nitric oxide deficit of Dahl S rats enhances hypertensive actions of angiotensin II
M Szentiványi, AP Zou, DL Mattson, P Soares, C Moreno, RJ Roman, AW Cowley
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2002
Arginine intake, blood pressure, and the incidence of acute coronary events in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
B Venho, S Voutilainen, VP Valkonen, J Virtanen, TA Lakka, TH Rissanen, ML Ovaskainen, M Laitinen, JT Salonen
The American journal of clinical nutrition 2002
Salt intake, endothelial dysfunction, and salt-sensitive hypertension.
Bragulat E, de la Sierra A
Journal of clinical hypertension (Greenwich, Conn.) 2002
Therapeutic modification of the l-arginine-eNOS pathway in cardiovascular diseases
G Goumas, C Tentolouris, D Tousoulis, C Stefanadis, P Toutouzas
Atherosclerosis 2001
Sodium Chloride Loading Does Not Alter Endothelium-Dependent Vasodilation of Forearm Vasculature in Either Salt-Sensitive or Salt-Resistant Patients with Essential Hypertension
Y HIGASHI, S SASAKI, K NAKAGAWA, M KIMURA, K NOMA, S SASAKI, K HARA, H MATSUURA, K CHAYAMA, T OSHIMA
Hypertension Research 2001
Differential nNOS gene expression in salt-sensitive and salt-resistant Dahl rats
H Castrop, A Kurtz
Journal of Hypertension 2001
Relative deficiency of nitric oxide-dependent vasodilation in salt-hypertensive Dahl rats: the possible role of superoxide anions
J Zicha, Z Dobešová, J Kuneš
Journal of Hypertension 2001
Increased dietary salt accelerates chronic allograft nephropathy in rats
PW Sanders, CL Gibbs, KM Akhi, LA Macmillan-Crow, KR Zinn, YF Chen, CJ Young, JA Thompson
Kidney International 2001
Dimethylarginines in chronic renal failure
N Wahbi, RN Dalton, C Turner, M Denton, I Abbs, R Swaminathan
Journal of clinical pathology 2001
Effects of aging and alterations in dietary sodium intake on total nitric oxide production
RJ Schmidt, WH Beierwaltes, C Baylis
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001
Decreased renal expression of nitric oxide synthase isoforms in adrenocorticotropin-induced and corticosterone-induced hypertension
YK Lou, C Wen, M Li, DJ Adams, MX Wang, F Yang, BJ Morris, JA Whitworth
Hypertension 2001
Nitric oxide synthase (NOS2) mutation in Dahl/Rapp rats decreases enzyme stability
WZ Ying, H Xia, PW Sanders
Circulation research 2001
Salt-Sensitive Hypertension and Inducible Nitric Oxide Synthase: Form-Function Dichotomy of a Coding Region Mutation, Mutatis Mutandis
J Loscalzo
Circulation research 2001
Endothelial Dysfunction in Salt-Sensitive Essential Hypertension
E Bragulat, A de la Sierra, MT Antonio, A Coca
Hypertension 2001
Intrarenal Transport and Vasoactive Substances in Hypertension
PA Ortiz, JL Garvin
Hypertension 2001
Induction of apoptosis during development of hypertensive nephrosclerosis1
WZ Ying, PX Wang, PW Sanders
Kidney International 2000
Abnormal pressure-natriuresis in hypertension: role of nitric oxide
Granger, Alexander
Acta Physiologica Scandinavica 2000
Effects of sodium intake on the pressor and renal responses to nitric oxide synthesis inhibition in normotensive individuals with different sodium sensitivity
G Barba, PJ Vallance, P Strazzullo, RJ MacAllister
Journal of Hypertension 2000
Overexpression of chloride channel CLC-K2 mRNA in the renal medulla of Dahl salt-sensitive rats
H Castrop, BK Krämer, GA Riegger, A Kurtz, K Wolf
Journal of Hypertension 2000
Renal cyclic 3′,5′-guanosine monophosphate and sodium excretion in Dahl salt-resistant and Dahl salt-sensitive rats
LJ Millatt, HM Siragy
Journal of Hypertension 2000
Tubulointerstitial injury and loss of nitric oxide synthases parallel the development of hypertension in the Dahl-SS Rat
RJ Johnson, KL Gordon, C Giachelli, T Kurth, MM Skelton, AW Cowley
Journal of Hypertension 2000
Role Of Nitric Oxide In Adrenocorticotrophin-Induced Hypertension: L-Arginine Effects Reversed By N-Nitro- L-Arginine
C Wen, M Li, JA Whitworth
Clinical and Experimental Pharmacology and Physiology 2000
Increased Endothelium-Monocyte Interactions in Salt-Sensitive Hypertension: Effect of L-Arginine
C Artigues, V Richard, C Roussel, F Lallemand, JP Henry, C Thuillez
Journal of Cardiovascular Pharmacology 2000
Control of arterial blood pressure and renal sodium excretion by nitric oxide synthase in the renal medulla
Mattson, Wu
Acta Physiologica Scandinavica 2000
Effect of Oral L-Arginine Administration for Three Weeks in Two Kidney-two Clip Hypertensive Rats
IJ de la Riva, MI Rosón, GW Vega, N Speziale, LE Albornoz, EL Palumbo, AJ Ferrero, PF Damiano
Archives Of Physiology And Biochemistry 2000
Potassium augments vascular relaxation mediated by nitric oxide in the carotid arteries of hypertensive Dahl rats
MS Zhou, H Kosaka, H Yoneyama
American Journal of Hypertension 2000
Blood pressure and metabolic changes during dietary L-arginine supplementation in humans
A Siani, E Pagano, R Iacone, L Iacoviello, F Scopacasa, P Strazzullo
American Journal of Hypertension 2000
Nitric oxide and salt sensitivity
LX Cubeddu, AB Alfieri, IS Hoffmann, E Jimenez, CM Roa, R Cubeddu, C Palermo, RM Baldonedo
American Journal of Hypertension 2000
Effects of NO donors and synthase agonists on endothelial cell uptake of l -Arg and superoxide production
AA Ogonowski, WH Kaesemeyer, L Jin, V Ganapathy, FH Leibach, RW Caldwell
American journal of physiology. Cell physiology 2000
l -Arginine increases nitric oxide production in isolated lungs of chronically hypoxic newborn pigs
CD Fike, MR Kaplowitz, LA Rehorst-Paea, LD Nelin
Journal of applied physiology 2000
Characterization of l -arginine transporters in rat renal inner medullary collecting duct
F Wu, B Cholewa, DL Mattson
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2000
Mechanisms of salt-sensitive hypertension: role of inducible nitric oxide synthase
DY Tan, S Meng, GW Cason, RD Manning
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2000
Interaction Between Nitric Oxide and Mineralocorticoids in the Long-Term Control of Blood Pressure
G Alvarez, A Osuna, R Wangensteen, F Vargas
Hypertension 2000
Study on the Relationship Between Plasma Nitrite and Nitrate Level and Salt Sensitivity in Human Hypertension: Modulation of Nitric Oxide Synthesis by Salt Intake
N Fujiwara, T Osanai, T Kamada, T Katoh, K Takahashi, K Okumura
Circulation 2000
Subpressor Dose of L-NAME Unmasks Hypertensive Effect of Chronic Hyperinsulinemia
M Bursztyn, J Mekler, E Peleg, J Bernheim
Hypertension 2000
Renal Structural Properties in Prehypertensive Dahl Salt-Sensitive Rats
F Tomoda, M Takata, H Kinuno, S Tomita, K Yasumoto, H Inoue
Hypertension 2000
Nitric Oxide and the Regulation of the Peripheral Circulation
PJ Kadowitz, DB McNamara
2000
Role of Female Sex Hormones in the Development and Reversal of Dahl Hypertension
C Hinojosa-Laborde, DL Lange, JR Haywood
Hypertension 2000
Textbook of Angiology
JB Chang
2000
Dysfunctional Renal Nitric Oxide Synthase as a Determinant of Salt-Sensitive Hypertension: Mechanisms of Renal Artery Endothelial Dysfunction and Role of Endothelin for Vascular Hypertrophy and Glomerulosclerosis
M Barton, I Vos, S Shaw, P Boer, LI D'uscio, HJ Gröne, TJ Rabelink, T Lattmann, P Moreau, TF Lüscher
Journal of the American Society of Nephrology : JASN 2000
L-arginine attenuates endothelial dysfunction in endotoxin-induced lung injury
BC Sheridan, RC Mclntyre, DR Meldrum, DA Fullerton
Surgery 1999
Salt sensitivity and cardiovascular risk
A Bataineh, L Raij
Current Opinion in Nephrology and Hypertension 1999
Hypertension, nitric oxide and end-organ damage
A Ishani, L Raij
Current Opinion in Nephrology and Hypertension 1999
Neural mechanisms in nitric-oxide-deficient hypertension
M Sander, RG Victor
Current Opinion in Nephrology and Hypertension 1999
A Mechanism of Oxygen Free Radical Production in the Dahl Hypertensive Rat
A Swei, F Lacy, FA Delano, DA Parks, GW Schmid-Schönbein
Microcirculation 1999
Coenzyme Q versus hypertension: does CoQ decrease endothelial superoxide generation?
MF McCarty
Medical Hypotheses 1999
Enhanced Nitric Oxide Synthesis Reverses Salt-Induced Alterations in Blood Flow and Cgmp Levels
MA Bayorh, E Williams, M Thierry-Palmer, G Sanford, N Emmett, S Harris-Hooker, RR Socci, TC Chu
Clinical and Experimental Hypertension 1999
Potassium Supplementation Increases Sodium Excretion and Nitric Oxide Production in Hypertensive Dahl Rats
MS Zhou, Y Nishida, H Yoneyama, QH Chen, H Kosaka
Clinical and Experimental Hypertension 1999
Human NK cells express endothelial nitric oxide synthase, and nitric oxide protects them from activation-induced cell death by regulating expression of TNF-alpha
K Shen, FA DeLano, BW Zweifach, GW Schmid-Schönbein
Journal of immunology (Baltimore, Md. : 1950) 1999
Dietary salt increases endothelial nitric oxide synthase and TGF-β1 in rat aortic endothelium
WZ Ying, PW Sanders
American journal of physiology. Heart and circulatory physiology 1999
Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition
MA Rudd, M Trolliet, S Hope, AW Scribner, G Daumerie, G Toolan, T Cloutier, J Loscalzo
American journal of physiology. Heart and circulatory physiology 1999
Nitric oxide synthase in the JGA of the SHR: expression and role in tubuloglomerular feedback
WJ Welch, A Tojo, JU Lee, DG Kang, CG Schnackenberg, CS Wilcox
American journal of physiology. Renal physiology 1999
Ontogenetic Aspects of Hypertension Development: Analysis in the Rat
J Zicha, J Kuneš
Physiological reviews 1999
Role of nitric oxide in the early renal hemodynamic response after unilateral nephrectomy
JM Valdivielso, F Pérez-Barriocanal, J García-Estañ, JM López-Novoa
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 1999
Role of Neuronal Nitric Oxide Synthase in Dahl Salt-Sensitive Hypertension
DY Tan, S Meng, RD Manning
Hypertension 1999
Handling 22 NaCl by the Blood-Brain Barrier and Kidney: Its Relevance to Salt-Induced Hypertension in Dahl Rats
S Simchon, W Manger, E Golanov, J Kamen, G Sommer, CH Marshall
Hypertension 1999
Renal Intramedullary Infusion of l -Arginine Prevents Reduction of Medullary Blood Flow and Hypertension in Dahl Salt-Sensitive Rats
N Miyata, AW Cowley
Hypertension 1999
Nitric Oxide–Induced Inhibition of Transport by Thick Ascending Limbs From Dahl Salt-Sensitive Rats
NH García, CF Plato, BA Stoos, JL Garvin
Hypertension 1999
Nitric Oxide Synthase Isotype Expression in Salt-Sensitive and Salt-Resistant Dahl Rats
Z Ni, F Oveisi, ND Vaziri
Hypertension 1999
A Large Blood Pressure–Raising Effect of Nitric Oxide Synthase Inhibition in Humans
M Sander, B Chavoshan, RG Victor
Hypertension 1999
Different Frequencies of Inducible Nitric Oxide Synthase Genotypes in Older Hypertensives
CL Glenn, WY Wang, BJ Morris
Hypertension 1999
Salt intake determines the renal response to L-arginine infusion in normal human subjects
YM Barri, CS Wilcox
Kidney International 1998
Dietary salt regulates expression of Tamm-Horsfall glycoprotein in rats
WZ Ying, PW Sanders
Kidney International 1998
Is the nitric oxide system involved in genetic hypertension in Dahl rats?
AY Deng
Kidney International 1998
Role of nitric oxide in vascular hyper-responsiveness to norepinephrine in hypertensive Dahl rats
Y Nishida, J Ding, MS Zhou, QH Chen, H Murakami, XZ Wu, H Kosaka
Journal of Hypertension 1998
Hypertension
P Hamet, Z Pausova, V Adarichev, K Adaricheva, J Tremblay
Journal of Hypertension 1998
Isoform-specific regulation of nitric oxide synthase mRNA in the kidney by sodium and blood pressure
S Nadaud, C Mao, G Luvàra, JB Michel, F Soubrier
Journal of Hypertension 1998
ROLE OF NITRIC OXIDE IN THE DEVELOPMENT OF CORTICOTROPIN-INDUCED HYPERTENSION IN SHEEP
JJ Tresham, CN May
Clinical and Experimental Pharmacology and Physiology 1998
Possible Mechanisms of Salt-Induced Hypertension in Dahl Salt-Sensitive Rats
MA Bayorh, EC Ogbolu, E Williams, M Thierry-Palmer, G Sanford, N Emmett, S Harris-Hooker, RR Socci, TC Chu, VM Chenault
Physiology & Behavior 1998
Chronic nitric oxide inhibition model six years on
R Zatz, C Baylis
Hypertension 1998
Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats
TK Gupta, M Toruner, MK Chung, RJ Groszmann
Hepatology 1998
Genetic mapping of soluble guanylyl cyclase genes: implications for linkage to blood pressure in the Dahl rat
M Azam, G Gupta, W Chen, S Wellington, D Warburton, RS Danziger
Hypertension 1998
Nitric oxide deficiency, leukocyte activation, and resultant ischemia are crucial to the pathogenesis of diabetic retinopathy/ neuropathy — preventive potential of antioxidants, essential fatty acids, chromium, ginkgolides, and pentoxifylline
MF McCarty
Medical Hypotheses 1998
Studies of Arginine Metabolism and Salt Sensitivity in the Dahl/Rapp Rat Models of Hypertension
PA Wood, DA Hamm, PY Chen, PW Sanders
Molecular Genetics and Metabolism 1998
Inverse Relationship of Urinary Cyclic GMP to Blood Pressure Reactivity in the CARDIA Study: Vasodilatory Regulation of Sympathetic Vasoconstriction
JH Markovitz, D Tucker, CE Lewis, PW Sanders, DG Warnock
Psychosomatic medicine 1998
Dietary salt enhances glomerular endothelial nitric oxide synthase through TGF-β1
WZ Ying, PW Sanders
American journal of physiology. Renal physiology 1998
l -Arginine prevents lung neutrophil accumulation and preserves pulmonary endothelial function after endotoxin
BC Sheridan, RC McIntyre, DR Meldrum, DA Fullerton
American journal of physiology. Lung cellular and molecular physiology 1998
The Utility of Nitric Oxide in the Postoperative Period
SC Body, SK Shernan
Seminars in cardiothoracic and vascular anesthesia 1998
Dietary salt modulates renal production of transforming growth factor-β in rats
WZ Ying, PW Sanders
American journal of physiology. Renal physiology 1998
Renal medullary interstitial infusion of l -arginine prevents hypertension in Dahl salt-sensitive rats
N Miyata, AP Zou, DL Mattson, AW Cowley
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 1998
Candidate Genes in the Regulation of Na + Transport by Inner Medullary Collecting Duct Cells From Dahl Rats
RF Husted, JP Rapp, JB Stokes
Hypertension 1998
Vascular Smooth Muscle Nitric Oxide Synthase Anomalies in Dahl/Rapp Salt-Sensitive Rats
PY Chen, RD Gladish, PW Sanders
Hypertension 1998
Inducible Nitric Oxide Synthase and Blood Pressure
DL Mattson, CY Maeda, TD Bachman, AW Cowley
Hypertension 1998
Enhanced Depressor Response to Nitric Oxide in the Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats
S Kagiyama, T Tsuchihashi, I Abe, M Fujishima
Hypertension 1998
Induction of P4504A Activity Improves Pressure-Natriuresis in Dahl S Rats
M Alonso-Galicia, B Frohlich, RJ Roman
Hypertension 1998
Concordant Genetic and Physiological Data Are Required for Candidate Genes
JP Rapp
Hypertension 1998
Hypertension and the Insulin Resistance Syndrome of Rats
I Klimeš, E Šeböková
Annals of the New York Academy of Sciences 1997
Relationship of diastolic blood pressure with cyclic GMP excretion among young adults (the CARDIA study)
JH Markovitz, CE Lewis, PW Sanders, D Tucker, DG Warnock
Journal of Hypertension 1997
NITRIC OXIDE, THE KIDNEY AND HYPERTENSION
C Schnackenberg, AR Patel, KA Kirchner, JP Granger
Clinical and Experimental Pharmacology and Physiology 1997
Ming Li, Tafline Fraser, Jian Wang* and Judith A Whitworth
J Whitworth
Clinical and Experimental Pharmacology and Physiology 1997
ROLE OF NITRIC OXIDE IN TUBULOGLOMERULAR FEEDBACK: EFFECTS OF DIETARY SALT
WJ Welch, CS Wilcox
Clinical and Experimental Pharmacology and Physiology 1997
EFFECT OF DIETARY SALT LOADING AND HIGH-CALCIUM DIET ON VASCULAR SMOOTH MUSCLE RESPONSES AND ENDOTHELIUM FUNCTION IN RATS
BJ Adegunloye, OA Sofola
Clinical and Experimental Pharmacology and Physiology 1997
Hypertension and the Insulin Resistance Syndrome of Rats.: Are They Related?
I Klimeš, E Šeböková
Annals of the New York Academy of Sciences 1997
Nitric oxide in renal health and disease
BC Kone
American Journal of Kidney Diseases 1997
Changes of the plasma endothelin in adaptation to increased salt intake in rats
H S Oh, K Yoo, M Kim, K C Choi, J U Lee
The Korean Journal of Internal Medicine 1997
L-Arginine Decreases Alveolar Macrophage Proinflammatory Monokine Production during Acute Lung Injury by a Nitric Oxide Synthase-Dependent Mechanism:
DR Meldrum, RC McIntyre, BC Sheridan, JC Cleveland, DA Fullerton, AH Harken
The Journal of Trauma: Injury, Infection and Critical Care 1997
Nitric Oxide Synthase and Renin-Angiotensin System Gene Expression in Salt-Sensitive and Salt-Resistant Sabra Rats
A Lippoldt, V Gross, K Schneider, A Hansson, S Nadaud, W Schneider, M Bader, C Yagil, Y Yagil, FC Luft
Hypertension 1997
Regional Renal Nitric Oxide Release in Stroke-Prone Spontaneously Hypertensive Rats
A Zuckerman, PN Chander, GA Zeballos, CT Stier
Hypertension 1997
Prolonged Reduction of High Blood Pressure With Human Nitric Oxide Synthase Gene Delivery
KF Lin, L Chao, J Chao
Hypertension 1997
Oxidative Stress in the Dahl Hypertensive Rat
A Swei, F Lacy, FA DeLano, GW Schmid-Schönbein
Hypertension 1997
Relationship Between Insulin Resistance and Endothelium-Dependent Vascular Relaxation in Patients With Essential Hypertension
Y Higashi, T Oshima, N Sasaki, N Ishioka, Y Nakano, R Ozono, M Yoshimura, K Ishibashi, H Matsuura, G Kajiyama
Hypertension 1997
Prolonged Administration of l -Arginine Ameliorates Chronic Pulmonary Hypertension and Pulmonary Vascular Remodeling in Rats
Y Mitani, K Maruyama, M Sakurai
Circulation 1997
Hypertension and the Heart
A Zanchetti, RB Devereux, L Hansson, S Gorini
1997
Asymmetrical Dimethylarginine, an Endogenous Nitric Oxide Synthase Inhibitor, in Experimental Hypertension
H Matsuoka, S Itoh, M Kimoto, K Kohno, O Tamai, Y Wada, H Yasukawa, G Iwami, S Okuda, T Imaizumi
Hypertension 1997
Effects of Chronic Nitric Oxide Synthase Inhibition on Cerebral Arterioles in Rats
JM Chillon, S Ghoneim, GL Baumbach
Hypertension 1997
Nitric Oxide and the Kidney
MS Goligorsky, SS Gross
1997
Endothelial Function in Hypertension
D Webb, P Vallance
1997
Primary renal abnormalities in hereditary hypertension
RG Woolfson, HE de Wardener
Kidney International 1996
Salt-sensitive hypertension: Lessons from animal models1
PW Sanders
American Journal of Kidney Diseases 1996
Localized administration of sodium nitroprusside enhances its protection against platelet aggregation in stenosed and injured coronary arteries
JT Willerson, SR Igo, SK Yao, JC Ober, MP Macris, JJ Ferguson
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital 1996
Pathophysiology of the vascular wall: the role of nitric oxide in renal disease
L Raij, E Jaimes, D Castillo, J Guerra, G Westberg
Prostaglandins Leukotrienes and Essential Fatty Acids 1996
Nitric Oxide and Renal Regulation of Sodium Excretion
FJ Salazar
Endothelium : journal of endothelial cell research 1996
Coordinate changes of renin and brain-type nitric-oxide-synthase (b-NOS) mRNA levels in rat kidneys
K Schricker, B Pötzl, M Hamann, A Kurtz
Pflügers Archiv - European Journal of Physiology 1996
Lipopolysaccharide and Tumor Necrosis Factor Stimulate Lung Microvascular Arginine Uptake, a Response Attenuated by Dexamethasone
M Pan, M Wasa, U Ryan, W Souba
JPEN. Journal of parenteral and enteral nutrition 1996
Chronic l -Arginine Administration Attenuates Cardiac Hypertrophy in Spontaneously Hypertensive Rats
H Matsuoka, M Nakata, K Kohno, Y Koga, G Nomura, H Toshima, T Imaizumi
Hypertension 1996
Salt Intake and Plasma Atrial Natriuretic Peptide and Nitric Oxide in Hypertension
VM Campese, M Tawadrous, R Bigazzi, S Bianchi, AS Mann, S Oparil, L Raij
Hypertension 1996
Impaired Renal Vasodilation and Urinary cGMP Excretion in Dahl Salt-Sensitive Rats
S Simchon, W Manger, G Blumberg, J Brensilver, S Cortell
Hypertension 1996
Nitric Oxide and the Regulation of Blood Pressure in the Hypertension-Prone and Hypertension-Resistant Sabra Rat
D Rees, D Ben-Ishay, S Moncada
Hypertension 1996
l -Arginine Restores Dilator Responses of the Basilar Artery to Acetylcholine During Chronic Hypertension
T Kitazono, FM Faraci, DD Heistad
Hypertension 1996
Effect of Salt Intake and Inhibitor Dose on Arterial Hypertension and Renal Injury Induced by Chronic Nitric Oxide Blockade
SS Yamada, AL Sassaki, CK Fujihara, DM Malheiros, GD Nucci, R Zatz
Hypertension 1996
l -Arginine Prevents Corticotropin-Induced Increases in Blood Pressure in the Rat
SW Turner, C Wen, M Li, JA Whitworth
Hypertension 1996
Renal Response to l -Arginine in Salt-Sensitive Patients With Essential Hypertension
Y Higashi, T Oshima, M Watanabe, H Matsuura, G Kajiyama
Hypertension 1996
Role of 20-HETE in Elevating Loop Chloride Reabsorption in Dahl SS/Jr Rats
AP Zou, HA Drummond, RJ Roman
Hypertension 1996
Blunted Pressure Natriuresis in Ovariectomized Dahl-Iwai Salt-Sensitive Rats
K Otsuka, H Suzuki, T Sasaki, N Ishii, H Itoh, T Saruta
Hypertension 1996
Nitric oxide
AJ Farrell, DR Blake
Annals of the rheumatic diseases 1996
Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat
AY Deng, JP Rapp
Journal of Clinical Investigation 1995
Glomerular actions of nitric oxide
L Raij, C Baylis
Kidney International 1995
Dietary L-Arginine Attenuates Blood Pressure in Mineralocorticoid-Salt Hypertensive Rats
P Laurant, B Demolombe, A Berthelot
Clinical and Experimental Hypertension 1995
Clinical biology of nitric oxide
MG Davies, GJ Fulton, PO Hagen
British Journal of Surgery 1995
Nitric Oxide
RA Schroeder, PC Kuo
Anesthesia & Analgesia 1995
Hypertension Is Not Related to Suppressed Lymphocyte Proliferation but to Elevated NO Synthesis in Vascular Smooth Muscle Cells of Borderline Hypertensive Rat
J Xiao, PK Pang
Blood Pressure 1995
The emerging multifaceted roles of nitric oxide
PC Kuo, RA Schroeder
Annals of Surgery 1995
L-arginine may mediate the therapeutic effects of low protein diets
I Narita, WA Border, M Ketteler, E Ruoslahti, NA Noble
Proceedings of the National Academy of Sciences 1995
Nitric Oxide: Physiology and Pharmacology
RA Schroeder, PC Kuo
Anesthesia & Analgesia 1995
Lack of Evidence for Linkage of the Endothelial Cell Nitric Oxide Synthase Gene to Essential Hypertension
A Bonnardeaux, S Nadaud, A Charru, X Jeunemaitre, P Corvol, F Soubrier
Circulation 1995
Renal Vasodilation With l -Arginine: Effects of Dietary Salt
X Deng, WJ Welch, CS Wilcox
Hypertension 1995
Nitric Oxide Synthase Isoform Activities in Kidney of Dahl Salt-Sensitive Rats
Y Ikeda, K Saito, JI Kim, M Yokoyama
Hypertension 1995
Effects of l -Arginine Infusion on Renal Hemodynamics in Patients With Mild Essential Hypertension
Y Higashi, T Oshima, R Ozono, M Watanabe, H Matsuura, G Kajiyama
Hypertension 1995
Stimulation of Endogenous Nitric Oxide Pathway by l -Arginine Reduces Declamp Mortality and Attenuates Hypertension Associated With Aortic Cross-Clamp–Induced Hindlimb Ischemia in Rats
JS Jin, LG DAlecy
Hypertension 1995
Dietary Sodium Intake Modulates Vasodilation Mediated by Nitroprusside But Not by Methacholine in the Human Forearm
CM Stein, R Nelson, M Brown, M Wood, AJ Wood
Hypertension 1995
Nitric Oxide and Its Putative Role in Hypertension
AF Dominiczak, DF Bohr
Hypertension 1995
Role of Nitric Oxide in Sepsis and ADRS
MP Fink, D Payen
1995
Beyond ACE inhibition: new developments in drug therapy for hypertension
LM Burrell, CI Johnston
The Medical Journal of Australia 1995
Endogenous nitric oxide synthesis determines sensitivity to the pressor effect of salt
JP Tolins, PJ Shultz
Kidney International 1994
Functional versus structural changes in the pathophysiology of acute ischemic renal failure in aging rats
M Sabbatini, G Sansone, F Uccello, LD Nicola, A Giliberti, V Sepe, P Magri, G Conte, VE Andreucci
Kidney International 1994
Cellular Biology of Glomerulosclerosis
EN Wardie
Renal Failure 1994
Physiological and pathophysiological roles of nitric oxide
AG Stewart, LH Phan, G Grigoriadis
Microsurgery 1994
Renal vasoconstriction during inhibition of NO synthase: Effects of dietary salt
X Deng, WJ Welch, CS Wilcox
Kidney International 1994
L-arginine decreases the infiltration of the kidney by macrophages in obstructive nephropathy and puromycin-induced nephrosis
AA Reyes, BH Porras, FI Chasalow, S Klahr
Kidney International 1994
Nitric Oxide in the Kidney: Synthesis, Localization, and Function
S Bachmann, P Mundel
American Journal of Kidney Diseases 1994
Salt sensitivity in hypertension. Renal and cardiovascular implications
VM Campese
Hypertension 1994
New perspectives in hypertension research. Potentials of vascular biology
VJ Dzau, GH Gibbons, R Morishita, RE Pratt
Hypertension 1994
Vascular responsiveness to nitric oxide synthesis inhibition in hypertensive rats
ML Pucci, KB Miller, LB Dick, H Guan, L Lin, A Nasjletti
Hypertension 1994
Long-term administration of L-arginine improves nitric oxide release from kidney in deoxycorticosterone acetate-salt hypertensive rats
H Hayakawa, Y Hirata, E Suzuki, K Kimura, K Kikuchi, T Nagano, M Hirobe, M Omata
Hypertension 1994
Renal apical membrane sodium-hydrogen exchange in genetic salt-sensitive hypertension
JL Lewis, DG Warnock
Hypertension 1994
Brain nitric oxide synthase activity in normal, hypertensive, and stroke-prone rats
N Clavier, JR Tobin, JR Kirsch, M Izuta, RJ Traystman
Stroke; a journal of cerebral circulation 1994
Beneficial Circulatory Effect of L-Arginine
T Nakaki, R Kato
The Japanese Journal of Pharmacology 1994
Adaptation to increased dietary salt intake in the rat. Role of endogenous nitric oxide
PJ Shultz, JP Tolins
Journal of Clinical Investigation 1993
Renal acid excretion and intracellular pH in salt-sensitive genetic hypertension
DC Batlle, AM Sharma, MW Alsheikha, M Sobrero, A Saleh, C Gutterman
Journal of Clinical Investigation 1993
Arginine feeding modifies cyclosporine nephrotoxicity in rats
LD Nicola, SC Thomson, LM Wead, MR Brown, FB Gabbai
Journal of Clinical Investigation 1993
Clonidine, but not bradykinin or ANP, inhibits Na+ and water transport in Dahl SS rat CCD
CT Hawk, JA Schafer
Kidney International 1993
Nitric oxide mediates renal vasodilation during erythropoietin-induced polycythemia
CS Wilcox, X Deng, AH Doll, H Snellen, WJ Welch
Kidney International 1993
The L-Arginine-Nitric Oxide Pathway
FH Epstein, S Moncada, A Higgs
New England Journal of Medicine 1993
Endothelial Activation and the Kidney: Vasomediator Modulation and Antioxidant Strategies
GM Vercellotti, JP Tolins
American Journal of Kidney Diseases 1993
Effect of L-Arginine Treatment in Pregnant Rats with Adriamycin Nephropathy
E Podjarny, A Pomeranz, M Rathaus, J Green, O Gonen, R Shamir, J Bernheim
Hypertension in Pregnancy 1993
Pregnancy restores the renal vasodilator response to glycine in Dahl salt-sensitive rats
SA Whitescarver, CM Heesch
Hypertension 1993
L-arginine administration normalizes pressure natriuresis in hypertensive Dahl rats
A Patel, S Layne, D Watts, KA Kirchner
Hypertension 1993
Essential hypertension: a renal disease? A review and update of the evidence
RG Luke
Hypertension 1993
Role of nitric oxide synthesis in salt-sensitive hypertension in Dahl/Rapp rats
PY Chen, PW Sanders
Hypertension 1993
L-arginine in the clinical arena: tool or remedy?
TF Lüscher, WE Haefeli
Circulation 1993
Salt-induced increase in arterial pressure during nitric oxide synthesis inhibition
FJ Salazar, A Alberola, JM Pinilla, JC Romero, T Quesada
Hypertension 1993
Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage
C Baylis, B Mitruka, A Deng
Journal of Clinical Investigation 1992
INHIBITION OF NO SYNTHESIS HAS AN ADDITIVE EFFECT ON HYPERTENSION INDUCED BY ACTH IN CONSCIOUS RATS
M Li, GJ Dusting, JA Whitworth
Clinical and Experimental Pharmacology and Physiology 1992
Nitric oxide synthase in macula densa regulates glomerular capillary pressure
CS Wilcox, WJ Welch, F Murad, SS Gross, G Taylor, R Levi, HH Schmidt
Proceedings of the National Academy of Sciences 1992

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