Immune functions were evaluated in vitro for PBMC isolated from healthy donors and cultured with the antiviral agents, 3'-azido-3'-deoxythymidine (AZT), ribavirin, ganciclovir, 2'3'-dideoxyinosine (ddI), or acyclovir. To identify methods for assessing the effects of antiviral drugs on immune cells, the PBMC response to mitogens, Con A, or phytohemagglutinin was evaluated from measurements of [3H]thymidine and [14C]-leucine incorporation, cell growth, cellular RNA, DNA, and protein levels, and the PBMC proliferative cycle (i.e., progression from G0----G1----S----G2 + M). At clinically relevant concentrations, AZT, ribavirin, or ganciclovir diminished PBMC responsiveness to mitogen. The numbers of proliferating cells in G1, S, and G2 + M phases of the cell cycle, DNA content, and [3H]thymidine uptake were decreased in cultures treated with AZT, ribavirin, or ganciclovir. AZT or ribavirin but not ganciclovir reduced RNA and protein in the cultures and inhibited cell growth. Whereas AZT, ribavirin, or ganciclovir were antiproliferative, ddI or acyclovir had little, if any, effect on PBMC mitogenesis. The inhibitory effects of antivirals on immune cells may contribute to the immune deterioration observed in patients following prolonged use of the drugs.
W Heagy, C Crumpacker, P A Lopez, R W Finberg
Title and authors | Publication | Year |
---|---|---|
Cytomegalovirus immunity with preemptive vs. prophylactic antiviral therapy after donor seropositive, recipient seronegative liver transplant
Danniel Zamora, Sayan Dasgupta, Terry Stevens-Ayers, Bradley Edmison, Drew Winston, Raymund Razonable, Aneesh Mehta, G. Marshall Lyon, Michael Boeckh, Nina Singh, David Koelle, Ajit Limaye |
JCI Insight | 2024 |
The hnRNP A2B1 is important for the replication of SFTSV and other RNA viruses
Zhang X, Yan LN, Liu BY, Zhou CM, Yu XJ |
Microbiology Spectrum | 2024 |
Effects of combined immunosuppressant and hepatitis B virus antiviral use on COVID-19 vaccination in recipients of living donor liver transplantation
Lee R, Choi J, Lee E, Lee J, Kim J, Kang S, An HI, Kim SH, Kim SM, Jwa EK, Park GC, Namgoong JM, Song GW, Yoon YI, Tak E, Lee SG |
PeerJ | 2024 |
Herpes Zoster: A Case Report of a Rare Ramification Leading to Secondary Infection.
Warrier S A, Ganesh S, Harikrishnan T, Balaji B, Venugopal DC, S S |
Cureus | 2023 |
A Review with Updated Perspectives on the Antiviral Potentials of Traditional Medicinal Plants and Their Prospects in Antiviral Therapy.
Saifulazmi NF, Rohani ER, Harun S, Bunawan H, Hamezah HS, Nor Muhammad NA, Azizan KA, Ahmed QU, Fakurazi S, Mediani A, Sarian MN |
2022 | |
The establishment of a cytomegalovirus -specific CD8+ T-cell threshold by kinetic modeling for the prediction of post-hemopoietic stem cell transplant reactivation.
Zhang J, Cao J, Zheng R, Yu M, Lin Z, Wang C, McCluskey J, Yang J, Chen Z, Corbett AJ, Cao P, Mo W, Wang Z |
iScience | 2022 |
Controversies’ clarification regarding ribavirin efficacy in measles and coronaviruses: Comprehensive therapeutic approach strictly tailored to COVID-19 disease stages
GD Liatsos |
World journal of clinical cases | 2021 |
Cytomegalovirus-specific T-cell reconstitution following letermovir prophylaxis after hematopoietic cell transplantation
D Zamora, ER Duke, H Xie, BC Edmison, B Akoto, R Kiener, T Stevens-Ayers, R Wagner, M Mielcarek, WM Leisenring, KR Jerome, JT Schiffer, G Finak, SC Rosa, M Boeckh |
Blood | 2021 |
A Systematic Review of the Clinical Pharmacokinetics, Pharmacodynamics and Toxicodynamics of Ganciclovir/Valganciclovir in Allogeneic Haematopoietic Stem Cell Transplant Patients
PR Selby, S Shakib, SL Peake, MS Warner, D Yeung, U Hahn, JA Roberts |
Clinical Pharmacokinetics | 2021 |
Cytomegalovirus replication is associated with enrichment of distinct γδ T cell subsets following lung transplantation: A novel therapeutic approach?
S Stankovic, MS Davey, EM Shaw, A von Borstel, Y Cristiano, BJ Levvey, J Rossjohn, GP Westall, GI Snell, AG Brooks, LC Sullivan |
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation | 2020 |
Immune disorders in the recuperation period. Justification of the Immunomax use
OA Gizinger |
2020 | |
Cytomegalovirus after kidney transplantation in 2020: moving towards personalized prevention
R Hellemans, D Abramowicz |
Nephrology Dialysis Transplantation | 2020 |
Effects of dietary supplementation with S. platensis and probiotics on the growth performance, immune response and the fecal Lactobacillus spp. and E. coli contents of weaned piglets
L Zhang, P Jin, S Qin, J Liu, Z Yang, H Zhao, Q Sheng |
Livestock Science | 2019 |
Cytomegalovirus prevention strategies and the risk of BK polyomavirus viremia and nephropathy
T Reischig, M Kacer, O Hes, J Machova, J Nemcova, D Lysak, P Jindra, K Pivovarcikova, S Kormunda, M Bouda |
American Journal of Transplantation | 2019 |
Cytomegalovirus-Specific T-Cell Transfer for Refractory Cytomegalovirus Infection After Haploidentical Stem Cell Transplantation: The Quantitative and Qualitative Immune Recovery for Cytomegalovirus
XY Pei, XY Zhao, YJ Chang, J Liu, LP Xu, Y Wang, XH Zhang, W Han, YH Chen, XJ Huang |
The Journal of Infectious Diseases | 2017 |
Human Cytomegalovirus Infection Enhances NK Cell Activity In Vitro:
A Tschan-Plessl, M Stern, L Schmied, C Retière, HH Hirsch, C Garzoni, C Delden, K Boggian, NJ Mueller, C Berger, J Villard, O Manuel, P Meylan, G Terszowski |
Transplantation Direct | 2016 |
In vitro studies of the impact of maribavir on CMV-specific cellular immune responses
D Stachel, T Stevens-Ayers, M Boeckh |
Journal of Clinical Virology | 2016 |
Ribavirin for Chronic Hepatitis E Virus Infection in Transplant Recipients
N Kamar, J Izopet, S Tripon, M Bismuth, S Hillaire, J Dumortier, S Radenne, A Coilly, V Garrigue, L D'Alteroche, M Buchler, L Couzi, P Lebray, S Dharancy, A Minello, M Hourmant, AM Roque-Afonso, F Abravanel, S Pol, L Rostaing, V Mallet |
New England Journal of Medicine | 2014 |
Comparison of the chronic effects of ribavirin and caffeic acid phenethyl ester (CAPE) on pancreatic damage and hepatotoxicity
S Motor, H Alp, S Senol, N Pınar, VK Motor, I Kaplan, A Alp, C Gökçe |
International journal of clinical and experimental medicine | 2014 |
Randomized Trial of Valganciclovir Versus Valacyclovir Prophylaxis for Prevention of Cytomegalovirus in Renal Transplantation
T Reischig, M Kacer, P Jindra, O Hes, D Lysak, M Bouda |
Clinical journal of the American Society of Nephrology : CJASN | 2014 |
Cellular stress marker alteration and inflammatory response in pigs fed with an ochratoxin contaminated diet
C Bernardini, E Grilli, JC Duvigneau, A Zannoni, B Tugnoli, F Gentilini, T Bertuzzi, S Spinozzi, C Camborata, ML Bacci, A Piva, M Forni |
Research in Veterinary Science | 2014 |
Antiviral Drugs for Influenza and Other Respiratory Virus Infections
Aoki FY |
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases | 2014 |
Comparison of ribavirin and oseltamivir in reducing mortality and lung injury in mice infected with mouse adapted A/California/04/2009 (H1N1)
SG Zarogiannis, JW Noah, A Jurkuvenaite, C Steele, S Matalon, DL Noah |
Life Sciences | 2012 |
Advances in cytomegalovirus-preventive strategies in solid organ transplantation: defending pre-emptive therapy
T Reischig |
Expert Review of Anti-infective Therapy | 2012 |
Post-transplant liver biopsy and the immune response: lessons for the clinician
S Shetty, DH Adams, SG Hubscher |
Expert Review of Clinical Immunology | 2012 |
The Centrosome
H Schatten |
2012 | |
Immune-mediated complications of the graft in interferon-treated hepatitis C positive liver transplant recipients
N Selzner, M Guindi, EL Renner, M Berenguer |
Journal of Hepatology | 2011 |
The efficacy of ribavirin in the treatment of Crimean-Congo hemorrhagic fever in Eastern Black Sea region in Turkey
I Koksal, G Yilmaz, F Aksoy, H Aydin, I Yavuz, S Iskender, K Akcay, S Erensoy, R Caylan, K Aydin |
Journal of Clinical Virology | 2010 |
Prevention of Cytomegalovirus in Organ Transplant Recipients: Cross Roads Between Antiviral and Antitumor Immunity
N Singh |
Transplantation | 2010 |
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
VG Fowler, WM Scheld, AS Bayer |
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases | 2010 |
High efficacy and low toxicity of short-course oral valganciclovir as pre-emptive therapy for hematopoietic stem cell transplant cytomegalovirus infection
AJ Saleh, FA Mohareb, FA Rabiah, N Chaudhri, FA Sharif, HA Zahrani, SY Mohamed, M Patel, W Rasheed, Z Nurgat, M Bakr, S Ahmed, S Zaidi, A Nassar, K Ibrahim, HA Abdely, M Aljurf |
Hematology/Oncology and Stem Cell Therapy | 2010 |
Effect of Duration and Intensity of Ganciclovir Exposure on Lymphoblastoid Cell Toxicity
A Janoly-Dumenil, I Rouvet, N Bleyzac, Y Bertrand, G Aulagner, MT Zabot |
Antiviral Chemistry & Chemotherapy | 2009 |
Treatment of Crimean-Congo hemorrhagic fever
O Ergonul |
Antiviral Research | 2008 |
Respiratory viruses other than influenza virus: impact and therapeutic advances
WG Nichols, AJ Campbell, M Boeckh |
Clinical microbiology reviews | 2008 |
Therapeutic effects of combined treatment with ribavirin and tiazofurin on experimental autoimmune encephalomyelitis development: Clinical and histopathological evaluation
D Stojkov, I Lavrnja, S Pekovic, S Dacic, I Bjelobaba, M Mostarica-Stojkovic, S Stosic-Grujicic, S Jovanovic, N Nedeljkovic, L Rakic, M Stojiljkovic |
Journal of the Neurological Sciences | 2008 |
Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production
I Lavrnja, D Stojkov, I Bjelobaba, S Pekovic, S Dacic, N Nedeljkovic, M Mostarica-Stojkovic, S Stosic-Grujicic, L Rakic, M Stojiljkovic |
International Immunopharmacology | 2008 |
Photodynamic purging of alloreactive T cells for adoptive immunotherapy after haploidentical stem cell transplantation
K Perruccio, F Topini, A Tosti, A Carotti, T Aloisi, F Aversa, MF Martelli, A Velardi |
Blood Cells, Molecules, and Diseases | 2008 |
Mechanisms of genotoxicity of nucleoside reverse transcriptase inhibitors
OA Olivero |
Environmental and Molecular Mutagenesis | 2007 |
Predictors for persistent cytomegalovirus reactivation after T-cell-depleted allogeneic hematopoietic stem cell transplantation
NG Almyroudis, A Jakubowski, D Jaffe, K Sepkowitz, E Pamer, RJ O'Reilly, GA Papanicolaou |
Transplant Infectious Disease | 2007 |
Extrahepatic manifestations of Hepatitis C Virus infection: A general overview and guidelines for a clinical approach
AL Zignego, C Ferri, SA Pileri, P Caini, FB Bianchi |
Digestive and Liver Disease | 2007 |
African infants' CCL3 gene copies influence perinatal HIV transmission in the absence of maternal nevirapine
L Kuhn, DB Schramm, S Donninger, S Meddows-Taylor, AH Coovadia, GG Sherman, GE Gray, CT Tiemessen |
AIDS | 2007 |
Immunomodulatory effects of two HIV protease inhibitors, Saquinavir and Ritonavir, on lymphocytes from healthy seronegative individuals
OM Delmonte, G Bertolotto, E Ricotti, PA Tovo |
Immunology Letters | 2007 |
Hepatitis C virus-related lymphoproliferative disorders: an overview
AL Zignego, C Giannini, C Ferri |
World journal of gastroenterology : WJG | 2007 |
Crimean-Congo Hemorrhagic Fever
O Ergonul, CA Whitehouse |
2007 | |
HIV and the Pathogenesis of AIDS
JA Levy |
2007 | |
Treatment of Crimean-Congo Hemorrhagic Fever
Ergonul O, Mirazimi A, Dimitrov DS |
2007 | |
Factors accelerating liver fibrosis progression in renal transplant patients receiving ribavirin monotherapy for chronic hepatitis C
N Kamar, A Boulestin, J Selves, L Esposito, K Sandres-Saune, M St�benet, E Chatelut, D Durand, L Rostaing, J Izopet |
Journal of Medical Virology | 2005 |
Combination of Nucleoside Analogues Tiazofurin and Ribavirin Downregulates Experimental Autoimmune Encephalomyelitis
I Lavrnja, D Stojkov, S Peković, S Šubašić, M Mostarica-Stojković, S Stošic-Grujičić, N Nedeljković, L Medić-Mijačević, L Rakić, M Stojiljković |
Annals of the New York Academy of Sciences | 2005 |
Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation
K Perruccio, A Tosti, E Burchielli, F Topini, L Ruggeri, A Carotti, M Capanni, E Urbani, A Mancusi, F Aversa, MF Martelli, L Romani, A Velardi |
Blood | 2005 |
Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent hepatitis C following liver transplantation
RT Stravitz, ML Shiffman, AJ Sanyal, VA Luketic, RK Sterling, DM Heuman, A Ashworth, AS Mills, M Contos, AH Cotterell, D Maluf, MP Posner, RA Fisher |
Liver Transplantation | 2004 |
Respiratory Viruses and Severe Lower Respiratory Tract Complications in Hospitalized Patients
J Garbino, MW Gerbase, W Wunderli, L Kolarova, LP Nicod, T Rochat, L Kaiser |
Chest | 2004 |
Pegylating IFNs at His-34 Improves the in Vitro Antiviral Activity Through the JAK/STAT Pathway
MJ Grace, D Cutler |
Antiviral Chemistry & Chemotherapy | 2004 |
Hepatitis c virus-specific cytolytic t cell responses after antiviral therapy
C Morishima, L Musey, M Elizaga, K Gaba, M Allison, RL Carithers, DR Gretch, MJ McElrath |
Clinical Immunology | 2003 |
Long-term ribavirin therapy in hepatitis C virus-positive renal transplant patients: effects on renal function and liver histology
N Kamar, K Sandres-Saune, J Selves, D Ribes, O Cointault, D Durand, J Izopet, L Rostaing |
American Journal of Kidney Diseases | 2003 |
Evolution of hepatitis C virus quasispecies in renal transplant patients with de novo glomerulonephritis
N Kamar, L Rostaing, A Boulestin, K Sandres, M Dubois, D Ribes, A Modesto, D Durand, J Izopet |
Journal of Medical Virology | 2003 |
Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity
M Boeckh, W Leisenring, SR Riddell, RA Bowden, ML Huang, D Myerson, T Stevens-Ayers, ME Flowers, T Cunningham, L Corey |
Blood | 2003 |
The human 26S proteasome is a target of antiretroviral agents
M Piccinini, MT Rinaudo, N Chiapello, E Ricotti, S Baldovino, M Mostert, PA Tovo |
AIDS | 2002 |
PHARMACOLOGICAL AND BIOLOGICAL ASPECTS OF BASIC RESEARCH ON NUCLEOSIDE-BASED REVERSE TRANSCRIPTASE INHIBITORS
B Macchi, A Mastino |
Pharmacological Research | 2002 |
Immunomodulatory effect of zidovudine (ZDV) on cytotoxic T lymphocytes previously exposed to ZDV
S Francke, CG Orosz, J Hsu, LE Mathes |
Antimicrobial agents and chemotherapy | 2002 |
Ribavirin increases mitogen- and antigen-induced expression of CD40L on CD4+ T cells in vivo
A Bergamini, M Cepparulo, F Bolacchi, A Araco, G Tisone, D Ombres, G Rocchi, M Angelico |
Clinical & Experimental Immunology | 2002 |
Interferon alpha and ribavirin for membranoproliferative glomerulonephritis and hepatitis C infection
V Loustaud-Ratti, E Liozon, H Karaaslan, S Alain, F Paraf, YL Meur, F Denis, E Vidal |
The American Journal of Medicine | 2002 |
Randomized study of valacyclovir as prophylaxis against cytomegalovirus reactivation in recipients of allogeneic bone marrow transplants
P Ljungman, R de la Camara, N Milpied, L Volin, CA Russell, A Crisp, A Webster |
Blood | 2002 |
Vertical HIV-1 Transmission: Importance of Neutralizing Antibody Titer and Specificity
V Bongertz, CI Costa, VG Veloso, B Grinsztejn, EC Filho, G Calvet, JH Pilotto, ML Guimarães, MG Morgado |
Scandinavian Journal of Immunology | 2001 |
Ribavirin - current status of a broad spectrum antiviral agent
NJ Snell |
Expert Opinion on Pharmacotherapy | 2001 |
The Benefit of Long-term Interferon Alfa Therapy for Symptomatic Mixed Cryoglobulinemia (Cutaneous Vasculitis/Membranoproliferative Glomerulonephritis) Associated With Chronic Hepatitis C Infection
RA Willson |
Journal of Clinical Gastroenterology | 2001 |
Reduction in CD8+ cell noncytotoxic anti-HIV activity in individuals receiving highly active antiretroviral therapy during primary infection
SA Stranford, JC Ong, B Martinez-Marino, M Busch, FM Hecht, J Kahn, JA Levy |
Proceedings of the National Academy of Sciences | 2001 |
Antiviral drugs can inhibit lymphocyte apoptosis induced by cytomegalovirus antigens
J Briceño, J la Torre-Cisneros, A Alvarez-Kindelan, P Sanchez-Guijo, C Pera |
Transplantation Proceedings | 2001 |
Effect of zidovudine on the primary cytolytic T-lymphocyte response and T-cell effector function
S Francke, CG Orosz, KA Hayes, LE Mathes |
Antimicrobial agents and chemotherapy | 2000 |
Ribavirin enhancement of hepatitis C virus core antigen-specific type 1 T helper cell response correlates with the increased IL-12 level
SH Fang, LH Hwang, DS Chen, BL Chiang |
Journal of Hepatology | 2000 |
Hepatitis C virus-specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C
M E Cramp, S Rossol, S Chokshi, P Carucci, R Williams, N V Naoumov |
Gastroenterology | 2000 |
Treatment of recurrent hepatitis C following liver transplantation
T Bizollon, C Ducerf, J Baulieux, C Trepo |
Current Gastroenterology Reports | 1999 |
Nitric Oxide Modulates HIV-1 Replication
JB Mannick, JS Stamler, E Teng, N Simpson, J Lawrence, J Jordan, RW Finberg |
Journal of Acquired Immune Deficiency Syndromes | 1999 |
Hepatitis C virus recurrence after liver transplantation
T Bizollon, C Ducerf, C Trepo, D Mutimer |
Gut | 1999 |
Toxicology
R Neubert, D Neubert |
Toxicology | 1999 |
Effects of ribavirin on hepatitis C-associated nephrotic syndrome in four liver transplant recipients
HP Pham, C Feray, D Samuel, M Gigou, D Azoulay, V Paradis, F Ducret, B Charpentier, B Debuire, A Lemoine |
Kidney International | 1998 |
Combination therapy of chronic hepatitis C: an important step but not the final goal!
H Wedemeyer, WH Caselmann, MP Manns |
Journal of Hepatology | 1998 |
Antiviral prophylaxis and treatment in chickenpox
MM Ogilvie |
Journal of Infection | 1998 |
Effect of ribavirin on virus load and quasispecies distribution in patients infected with hepatitis C virus
JH Lee, M Wagner, WK Roth, G Teuber, C Sarrazin, S Zeuzem |
Journal of Hepatology | 1998 |
Ribavirin inhibits protein synthesis and cell proliferation induced by mitogenic factors in primary human and rat hepatocytes: Ribavirin Inhibits Protein Synthesis and Cell Proliferation Induced by Mitogenic Factors in Primary Human and Rat Hepatocytes
GP Ilyin, S Langouët, M Rissel, JG Delcros, A Guillouzo, C Guguen-Guillouzo |
Hepatology | 1998 |
Lack of immunotoxicity of saquinavir (Ro 31-8959) used alone or in double or triple combination with AZT and ddC
M Viora, G Di Genova, M G Quaranta, M Boirivant, B Camponeschi |
Journal of Clinical Immunology | 1998 |
Zidovudine administered to women infected with human immunodeficiency virus type 1 and to their neonates reduces pediatric infection independent of an effect on levels of maternal virus
LF Aleixo, MM Goodenow, JW Sleasman |
The Journal of Pediatrics | 1997 |
Interference with cell cycle progression and induction of apoptosis by dideoxynucleoside analogs
M Viora, GD Genova, R Rivabene, W Malorni, A Fattorossi |
International Journal of Immunopharmacology | 1997 |
Herpetic stromal disease: Response to acyclovir/steroid therapy
WJ O'Brien, AP Segundo, J Guy, EM Dorn, JL Taylor |
Acta Ophthalmologica Scandinavica | 1996 |
Evidence that high-dosage zidovudine at time of retrovirus exposure reduces antiviral efficacy
LE Mathes, KA Hayes, G Kociba |
Antimicrobial agents and chemotherapy | 1996 |
The Immunomodulatory Effects of Antibiotics: In Vitro and Ex Vivo Investigations of 21 Substances by Means of the Lymphocyte Transformation Test
S Schubert, BH Andresen, V Bäahr, L Fischer, R Stamp, G Stricker, JW Wittke, U Ullmann |
Zentralblatt für Bakteriologie | 1996 |
Zidovudine and psoriasis
RB Stricker, B Goldberg |
Journal of the American Academy of Dermatology | 1996 |
In vitro lymphotoxicity and selective t cell immunotoxicity of high doses of acyclovir and its derivatives in mice
L Poluektova, K Krzystyniak, R Desjardins, D Flipo, M Fournier |
International Journal of Immunopharmacology | 1996 |
A PILOT STUDY OF RIBAVIRIN THERAPY FOR RECURRENT HEPATITIS C VIRUS INFECTION AFTER LIVER TRANSPLANTATION1:
MS Cattral, M Krajden, IR Wanless, M Rezig, R Cameron, PD Greig, SW Chung, GA Levy |
Transplantation | 1996 |
HIV-1 chemotherapy and drug resistance
R Daquila |
Clinical and Diagnostic Virology | 1995 |
A pilot, open-labelled, phase II study using oral ribavirin in the treatment of patients with chronic active hepatitis B
MJ Tong, SJ Hwang, M Lefkowitz, SD Lee, RL Co, KJ Lo |
Clinical and Diagnostic Virology | 1995 |
Evaluation of the Immunotoxicity of Antiretroviral Drugs Using an In Vitro Method for the Induction and Measurement of a Specific Antibody Response in Human Peripheral Blood Lymphocytes
AL Luzzati, E Giacomini, L Giordani |
Alternatives to laboratory animals : ATLA | 1995 |
Correlation of serum HCV RNA and alanine aminotransferase levels in chronic hepatitis C patients during treatment with ribavirin
MJ Tong, SJ Hwang, M Lefkowitz, SD Lee, RL Co, A Conrad, P Schmid, KJ Lo |
Journal of Gastroenterology and Hepatology | 1994 |
9-(2-Phosphonylmethoxyethyl) adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system
N Villani, R Caliò, E Balestra, J Balzarini, ED Clercq, E Fabrizi, CF Perno, VD Gobbo |
Antiviral Research | 1994 |
Aciclovir: A Reappraisal of its Antiviral Activity, Pharmacokinetic Properties and Therapeutic Efficacy
AJ Wagstaff, D Faulds, KL Goa |
Drugs | 1994 |
Acyclovirl is it an effective virostatic agent for orofacial infections?
CL Lavelle |
Journal of Oral Pathology and Medicine | 1993 |
Pilot study of ribavirin and interferon-β for chronic hepatitis B
S Kakumu, K Yoshioka, T Wakita, T Ishikawa, M Takayanagi, Y Higashi |
Hepatology | 1993 |
Primary Infection with Zidovudine-Resistant Human Immunodeficiency Virus Type 1
A Erice, DL Mayers, DG Strike, KJ Sannerud, FE McCutchan, K Henry, HH Balfour |
New England Journal of Medicine | 1993 |
Viruses, chemotherapy and immunity
MJ Koziel, BD Walker |
Parasitology | 1992 |
Antiviral therapy: current concepts and practices
B Bean |
Clinical microbiology reviews | 1992 |
A Controlled Trial Comparing Continued Zidovudine with Didanosine in Human Immunodeficiency Virus Infection
JO Kahn, SW Lagakos, DD Richman, A Cross, C Pettinelli, S Liou, M Brown, PA Volberding, CS Crumpacker, G Beall, HS Sacks, TC Merigan, M Beltangady, L Smaldone, R Dolin |
New England Journal of Medicine | 1992 |
Psoriasis and human immunodeficiency virus infection
ML Obuch, TA Maurer, B Becker, TG Berger |
Journal of the American Academy of Dermatology | 1992 |
Topics in Clinical Pharmacology: Ganciclovir
S Paul, S Dummer |
The American Journal of the Medical Sciences | 1992 |
Didanosine: A Review of its Antiviral Activity, Pharmacokinetic Properties and Therapeutic Potential in Human Immunodeficiency Virus Infection
D Faulds, RN Brogden |
Drugs | 1992 |