Citations to this article

Generation and analysis of clonal IgM- and IgG-producing human B cell lines expressing an anti-DNA-associated idiotype.
A J Manheimer-Lory, … , N R Hannigan, B A Diamond
A J Manheimer-Lory, … , N R Hannigan, B A Diamond
Published May 1, 1991
Citation Information: J Clin Invest. 1991;87(5):1519-1525. https://doi.org/10.1172/JCI115162.
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Research Article

Generation and analysis of clonal IgM- and IgG-producing human B cell lines expressing an anti-DNA-associated idiotype.

Abstract

This study describes a methodology for generating stable, cloned, EBV-transformed IgG- and IgM-producing human B cell lines. Using these lines we have characterized immunoglobulin V gene utilization in an anti-DNA-associated idiotypic system. The 31 anti-DNA-associated idiotype is encoded preferentially by the VK1 gene family, and, in all probability, reflects a germ line gene-encoded framework determinant. Analysis of these lines indicates that the DNA-binding antibodies produced by B cell lines from SLE patients may differ from DNA binding myeloma proteins and from natural autoantibodies.

Authors

A J Manheimer-Lory, A Davidson, D Watkins, N R Hannigan, B A Diamond

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Year: 2012 2011 2007 1999 1995 1994 1993 1992 1991 Total
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Citations to this article (20)

Title and authors Publication Year
A model for lupus brain disease: Antibody to NMDA receptor in SLE
B Diamond, BT Volpe 		Immunological Reviews 2012
Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by coculture with macrophage feeder cells
KK Hwang, X Chen, DM Kozink, M Gustilo, DJ Marshall, JF Whitesides, HX Liao, R Catera, CC Chu, XJ Yan, MA Luftig, BF Haynes, N Chiorazzi 		Blood 2011
Systemic lupus erythematosus
KN Kim 		Korean Journal of Pediatrics 2007
Monoclonal anti-endothelial cell antibodies from a patient with Takayasu arteritis activate endothelial cells from large vessels
M Blank, I Krause, T Goldkorn, S Praprotnik, A Livneh, P Langevitz, E Kaganovsky, S Morgenstern, S Cohen, V Barak, A Eldor, B Weksler, Y Shoenfeld 		Arthritis & Rheumatism 1999
Normal Human Cord Blood B Cells can Produce High Affinity IgG Antibodies to dsDNA that are Recognized by Cord Blood-Derived Anti-Idiotypic Antibodies
RJ Warrington, SK Wong, S Ramdahin, WJ Rutherford 		Scandinavian Journal of Immunology 1995
Analysis of the VKI Family: Germline Genes from an SLE Patient and Expressed Autoantibodies
A Manheimer-Lory, R Monhian, A Splaver, B Gaynor, B Diamond 		Autoimmunity 1995
Molecular Characterization of Monoclonal IgM Derived from Human B Cell Lines Expressing the 4C9 Rheumatoid Factor Associated Idiotype
A Davidson, RE Schrohenloher, WJ Koopman 		Autoimmunity 1995
Analysis of V kI and VLDII Light Chain Genes in the Expressed B-Cell Repertoirea
A Manheimer-Lory, M Irigoyen, B Gaynor, R Monhian, A Splaver, B Diamond 		Annals of the New York Academy of Sciences 1995
Analysis of human monoclonal antibodies elicited by vaccination with a Cryptococcus neoformans glucuronoxylomannan capsular polysaccharide vaccine
L Pirofski, R Lui, M DeShaw, AB Kressel, Z Zhong 		Infection and immunity 1995
Analysis of the V K I Family: Germline Genes from an SLE Patient and Expressed Autoantibodies
A Manheimer-Lory, R Monhian, A Splaver, B Gaynor, B Diamond 		Autoimmunity 1995
Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated
K Youngblood, L Fruchter, G Ding, J Lopez, V Bonagura, A Davidson 		Journal of Clinical Investigation 1994
Serological and genetic characterization of a human monoclonal immunoglobulin G anti-DNA idiotype
MR Ehrenstein, CM Longhurst, DS Latchman, DA Isenberg 		Journal of Clinical Investigation 1994
Characterization of two Human Anti-DNA Antibodies Bearing the Pathogenic Idiotype 8.12
E Paul, B Diamond 		Autoimmunity 1993
Production and analysis of IgG monoclonal anti-DNA antibodies from systemic lupus erythematosus (SLE) patients
M Ehrenstein, C Longhurst, DA Isenberg 		Clinical & Experimental Immunology 1993
Variable region sequences of autoantibodies from mice with experimental systemic lupus erythematosus
A Waisman, E Mozes 		European Journal of Immunology 1993
A Potent, Neutralizing Human Monoclonal Antibody against a Unique Epitope Overlapping the CD4-Binding Site of HIV-1 gp120 That Is Broadly Conserved across North American and African Virus Isolates
A Pinter, WJ Honnen, ME Racho, SA Tilley 		AIDS Research and Human Retroviruses 1993
The Humoral Immune Response in Autoimmunity
NJ Calvanico 		Dermatologic Clinics 1993
Production and analysis of IgG monoclonal anti-DNA antibodies from systemic lupus erythematosus (SLE) patients.
Ehrenstein M, Longhurst C, Isenberg DA 		Clinical & Experimental Immunology 1993
Immortalisation of Human Antibody Producing Cells
JK Kalsi, DA Isenberg 		Autoimmunity 1992
Molecular characteristics of antibodies bearing an anti-DNA-associated idiotype
A Manheimer-Lory, JB Katz, M Pillinger, C Ghossein, A Smith, B Diamond 		Journal of Experimental Medicine 1991

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