Citations to this article

Molecular analysis of major histocompatibility complex alleles associated with the lupus anticoagulant.
F C Arnett, … , K L Anderson, J D Reveille
F C Arnett, … , K L Anderson, J D Reveille
Published May 1, 1991
Citation Information: J Clin Invest. 1991;87(5):1490-1495. https://doi.org/10.1172/JCI115158.
View: Text | PDF
Research Article Article has an altmetric score of 3

Molecular analysis of major histocompatibility complex alleles associated with the lupus anticoagulant.

Abstract

Autoantibodies to phospholipids (APA) occur frequently in systemic lupus erythematosus (SLE) and other autoimmune disorders and predispose to intravascular thromboses. Major histocompatibility complex (MHC) class II alleles (HLA-DR and DQ) were determined by restriction fragment length polymorphisms (RFLP) in 20 patients with APA (lupus anticoagulant). HLA-DQw7 (DQB1*0301), linked to HLA-DR5 and -DR4 haplotypes, occurred in 70% and was significantly increased compared to 139 race-matched normal controls (P = 0.002, P corrected [pc] = 0.05, odds ratio [OR] = 5.1). Moreover, the frequency of HLA-DQw7 was significantly higher in SLE patients with APA as compared with patients without APA but with other autoantibodies, including anti-Ro and La (P = 0.0001, pc = 0.002, OR = 10.7), anti-Ro alone (P = 0.001, pc = 0.02, OR = 11.2), anti-dsDNA (P = 0.001, pc = 0.02, OR = 7.1), and possibly anti-Sm (P = 0.04, pc = NS, OR = 6.8) and anti-nRNP (U1-RNP) (P = 0.01, pc = NS, OR = 7.8). The DQB1*0301 allele of DQw7 showed the strongest association, while the frequencies of the DQA1*0301 (45%) and DQA1*0501 (50%) alleles did not differ from the controls. Among the HLA-DQB1*0301 (DQw7) negative patients, all possessed HLA-DQw8 (DQB1*0302) and/or HLA-DQw6 (DQB1*0602 or DQB1*0603) alleles. The HLA-DQB1*0301 chain shares an identical seven amino acid sequence with DQB1*0302, *0602, and *0603 chains in the third hypervariable region of the HLA-DQ molecule. This candidate "epitope" may play a role in mediating an autoimmune response to APA.

Authors

F C Arnett, M L Olsen, K L Anderson, J D Reveille

×

Total citations by year

Year: 2022 2021 2020 2019 2018 2017 2016 2015 2011 2009 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 Total
Citations: 1 1 1 1 1 1 1 1 6 2 2 4 1 5 4 3 5 3 4 3 4 8 7 8 4 5 86
Citation information

Citations to this article (86)

Title and authors Publication Year
Predicting diagnostic gene expression profiles associated with immune infiltration in patients with lupus nephritis
Wang L, Yang Z, Yu H, Lin W, Wu R, Yang H, Yang K 		Frontiers in immunology 2022
Lupus Anticoagulant in Gulf War Illness and Autoimmune Disorders: A Common Pathway Toward Autoimmunity.
James LM, Johnson RA, Lewis SM, Carpenter AF, Engdahl BE, Krug HE, Georgopoulos AP 		Journal of immunological sciences 2021
MicroRNA (miRNA): A New Dimension in the Pathogenesis of Antiphospholipid Syndrome (APS)
PJ Kotyla, A Islam 		International journal of molecular sciences 2020
HLA DRB1 and HLA DQB1 Alleles in Bulgarian Patients with Primary and Secondary Antiphospholipid Syndrome
M Baleva, M Nikolova-Vlahova, T Lukanov, M Ivanova-Shivarova, Z Karagjozova, F Martinova, E Naumova 		Acta Medica Bulgarica 2019
Cellular and Molecular Mechanisms of Anti-Phospholipid Syndrome
M Radic, D Pattanaik 		Frontiers in immunology 2018
Major Histocompatibility Complex Class II Alleles Influence Induction of Pathogenic Antiphospholipid Antibodies in a Mouse Model of Thrombosis: INFLUENCE OF MHC CLASS II ALLELES ON PRODUCTION OF PATHOGENIC aPL
E Papalardo, Z Romay-Penabad, R Willis, P Christadoss, AL Carrera-Marin, E Reyes-Maldonado, R Rudrangi, S Alfieri-Papalardo, E Garcia-Latorre, M Blank, S Pierangeli, AR Brasier, EB Gonzalez 		Arthritis & Rheumatology 2017
Genetic aspects of the antiphospholipid syndrome: An update
GD Sebastiani, A Iuliano, L Cantarini, M Galeazzi 		Autoimmunity Reviews 2016
Pathogenetic mechanisms of antiphospholipid antibody production in antiphospholipid syndrome
R Willis 		World Journal of Rheumatology 2015
Pathophysiology of the antiphospholipid antibody syndrome
R Willis, SS Pierangeli 		Autoimmunity Highlights 2011
ANTIPHOSPHOLIPID SYNDROME
T Avčin, KM O’Neil 		Textbook of Pediatric Rheumatology 2011
Systemic lupus erythematosus one disease or many?
N Agmon-Levin, M Mosca, M Petri, Y Shoenfeld 		Autoimmunity Reviews 2011
Antiphospholipid Syndrome
T Atsumi, O Amengual, T Koike 		Systemic Lupus Erythematosus 2011
Major Histocompatibility Complex Class II
MM Fernando, TJ Vyse 		Systemic Lupus Erythematosus 2011
HLA Association in SLE patients from Lahore-Pakistan
Nageen Hussain, Ghazala Jaffery, Anjum Nasim Sabri, Shahida Hasnain 		BOSNIAN J BASIC MED 2011
Genetic studies of systemic lupus erythematosus in Asia: where are we now?
I Kim, YJ Kim, K Kim, C Kang, CB Choi, YK Sung, HS Lee, SC Bae 		Genes and Immunity 2009
Genetic risk factors of thrombosis in the antiphospholipid syndrome
J Castro-Marrero, E Balada, M Vilardell-Tarrés, J Ordi-Ros 		British Journal of Haematology 2009
Handbook of Systemic Autoimmune Diseases
M Karmegam, RJ Quigg 		Handbook of Systemic Autoimmune Diseases 2007
Review: Familial lupus and antiphospholipid syndrome
AL Sestak, KM O'Neil 		Lupus 2007
The genetic basis of autoantibody production
JD Reveille 		Autoimmunity Reviews 2006
Systemic Lupus Erythematosus
M Petri 		JCR: Journal of Clinical Rheumatology 2006
The Autoimmune Diseases
I Kang, J Craft 		The Autoimmune Diseases 2006
Hughes Syndrome
MA Khamashta 		2006
Ethnic and geographical variation in antiphospholipid (Hughes) syndrome
I Uthman, M Khamashta 		Annals of the rheumatic diseases 2005
Genetics of antiphospholipid syndrome
T Horita, JT Merrill 		Current Rheumatology Reports 2004
Association of HLA-DM polymorphism with the production of antiphospholipid antibodies
ML Sanchez, K Katsumata, T Atsumi, FI Romero, ML Bertolaccini, A Funke, O Amengual, E Kondeatis, RW Vaughan, A Cox, GR Hughes, MA Khamashta 		Annals of the rheumatic diseases 2004
Is HLA class II susceptibility to primary antiphospholipid syndrome different from susceptibility to secondary antiphospholipid syndrome?
MV Freitas, LM da Silva, NH Deghaide, EA Donadi, P Louzada-Júnior 		Lupus 2004
Familial antiphospholipid antibodies and acquired circulating anticoagulants
I ElHajj, I Uthman, A Chahel, F Khoury, T Arayssi, A Taher 		Lupus 2004
Systemic lupus erythematosus in southern Spain: a comparative clinical and genetic study between Caucasian and Gypsy patients
LM Ramal, MA López-Nevot, JM Sabio, L Jáimez, L Paco, J Sánchez, E Ramón, A Fernández-Nebro, N Ortego, A Ruiz-Cantero, F Rivera, J Martín, J Jiménez-Alonso 		Lupus 2004
Antiphospholipid syndrome: Genetic review
B Namjou 		Current Rheumatology Reports 2003
Increased frequency of the mannose-binding lectin LX haplotype in Chinese systemic lupus erythematosus patients
YF Huang, W Wang, JY Han, XW Wu, ST Zhang, CJ Liu, QG Hu, P Xiong, RM Hamvas, N Wood, FL Gong, AH Bittles 		European Journal of Immunogenetics 2003
Antiphospholipid antibodies: discovery, definitions, detection and disease
JA McIntyre, DR Wagenknecht, WP Faulk 		Progress in Lipid Research 2003
HLA class II alleles and genetic predisposition to the antiphospholipid syndrome
GD Sebastiani, G Minisola, M Galeazzi 		Autoimmunity Reviews 2003
The molecular basis of complete complement C4A and C4B deficiencies in a systemic lupus erythematosus patient with homozygous C4A and C4B mutant genes
KL Rupert, JM Moulds, Y Yang, FC Arnett, RW Warren, JD Reveille, BL Myones, CA Blanchong, CY Yu 		Journal of immunology (Baltimore, Md. : 1950) 2002
The Antiphospholipid Syndrome II
M Ehrenfeld, H Amital, Y Shenfeld 		The Antiphospholipid Syndrome II 2002
Antiphospholipid syndrome
SC Keswani, N Chauhan 		Journal of the Royal Society of Medicine 2002
GENETICS OF ANTIPHOSPHOLIPID SYNDROME
T Atsumi, ML Bertolaccini, T Koike 		Rheumatic Disease Clinics of North America 2001
Vascular Manifestations of Systemic Autoimmune Diseases
C Kallenberg, JC Tervaert 		Vascular Manifestations of Systemic Autoimmune Diseases 2001
HLA Antigens in Malay Patients with Systemic Lupus Erythematosus : Association with Clinical and Autoantibody Expression
M Azizah, S Ainol, N Kong, Y Normaznah, M Rahim 		The Korean Journal of Internal Medicine 2001
HLA antigens in Malay patients with systemic lupus erythematosus: association with clinical and autoantibody expression
M R Azizah, S S Ainol, N C Kong, Y Normaznah, M N Rahim 		The Korean Journal of Internal Medicine 2001
Prothrombotic Disorders in Children With Moyamoya Syndrome
M Bonduel, M Hepner, G Sciuccati, AF Torres, S Tenembaum 		Stroke; a journal of cerebral circulation 2001
GENETICS OF SYSTEMIC LUPUS ERYTHEMATOSUS
KE Sullivan 		Rheumatic Disease Clinics of North America 2000
HLA and Systemic Vasculitides, Systemic Lupus Erythematosus and Sjögren's Syndrome
MC Pickering, M Perraudeau, MJ Walport 		2000
HLA class II alleles associations of anticardiolipin and anti b2GPI antibodies in a large series of European patients with systemic lupus erythematosus
M Galeazzi, GD Sebastiani, A Tincani, JC Piette, F Allegri, G Morozzi, F Bellisai, R Scorza, GB Ferrara, C Carcassi, J Font, G Passiu, J Smolen, C Papasteriades, F Houssiau, AF Nebro, ED Garrido, A Jedryka-Goral, R Marcolongo 		Lupus 2000
Familial Occurrence of Primary Antiphospholipid Syndrome
A Cantalapiedra, AG Avello, JL Navarro, JM Cesar 		Thrombosis Research 1999
HLA associations of anti-beta2 glycoprotein I response in a Greek cohort with antiphospholipid syndrome and meta-analysis of four ethnic groups
JP Ioannidis, MG Tektonidou, PG Vlachoyiannopoulos, C Stavropoulos-Giokas, M Spyropoulou-Vlachou, JD Reveille, FC Arnett, HM Moutsopoulos 		Human Immunology 1999
Associations of anti-?2-glycoprotein I autoantibodies with HLA class II alleles in three ethnic groups
FC Arnett, P Thiagarajan, C Ahn, JD Reveille 		Arthritis & Rheumatism 1999
Familial antiphospholipid antibody syndrome: Criteria for disease and evidence for autosomal dominant inheritance
N Goel, TL Ortel, D Bali, JP Anderson, IS Gourley, H Smith, CA Morris, M DeSimone, DW Branch, P Ford, D Berdeaux, RA Roubey, DD Kostyu, SF Kingsmore, T Thiel, C Amos, MF Seldin 		Arthritis & Rheumatism 1999
LUPUS ANTICOAGULANTS AND ANTIPHOSPHOLIPID ANTIBODIES
P Thiagarajan, SS Shapiro 		Hematology/Oncology Clinics of North America 1998
GENETIC SUSCEPTIBILITY TO SYSTEMIC LUPUS ERYTHEMATOSUS
TJ Vyse, BL Kotzin 		Annual Review of Immunology 1998
Clinical correlates, serum autoantibodies and the role of the major histocompatibility complex in French Canadian and non-French Canadian Caucasians with SLE
TA Podrebarac, DM Boisert, R Goldstein 		Lupus 1998
HLA-DR7 in Association with Chlorpromazine-induced Lupus Anticoagulant (LA)
G Vargas-Alarcón, JK Yamamoto-Furusho, J Zuñiga, R Canoso, J Granados 		Journal of Autoimmunity 1997
Follicular mucinosis associated with scarring alopecia, oligoclonal T-cell receptor Vβ expansion, and Staphylococcus aureus: When does follicular mucinosis become mycosis fungoides?
CM Jackow, E Papadopoulos, B Nelson, JA Tschen, G Heatherington, M Duvic 		Journal of the American Academy of Dermatology 1997
Antiphospholipid antibodies and the antiphospholipid antibody syndrome
GT Nahass 		Journal of the American Academy of Dermatology 1997
Relationship of anticardiolipin antibodies and antiphospholipid syndrome to HLA-DR7 in Mexican patients with systemic lupus erythematosus (SLE)
J Granados, G Vargas-Alarcón, C Drenkard, F Andrade, H Melín-Aldana, J Alcocer-Varela, D Alarcón-Segovia 		Lupus 1997
Genetic basis of systemic lupus erythematosus
TJ Vyse, BL Kotzin 		Current Opinion in Immunology 1996
The immunogenetics of the antiphospholipid syndrome, anticardiolipin antibodies, and lupus anticoagulant
GD Sebastiani, M Galeazzi, G Morozzi, R Marcolonao 		Seminars in Arthritis and Rheumatism 1996
A common major histocompatibility complex class II allele HLA-DQB1* 0301 is present in clinical variants of pemphigoid
JC Delgado, D Turbay, EJ Yunis, JJ Yunis, ED Morton, K Bhol, R Norman, CA Alper, RA Good, R Ahmed 		Proceedings of the National Academy of Sciences 1996
Immunology of the antiphospholipid antibody syndrome
RA Roubey 		Arthritis & Rheumatism 1996
Review : Histocompatibility genes in antiphospholipid antibody syndrome
WA Wilson 		Lupus 1996
Genetics of tumour necrosis factor in systemic lupus erythematosus
AG Wilson, GW Duff 		Lupus 1996
Genetic Risk Factors for aPL Syndrome
WA Wilson, AE Gharavi 		Lupus 1996
Manual of Biological Markers of Disease
WJ van Venrooij, RN Maini 		1996
One Hundred Anti-Ro (SS-A) Antibody Positive Patients
E Simmons-O'brien, S Chen, R Watson, C Antoni, M Petri, M Hochberg, MB Stevens, TT Provost 		Medicine 1995
Association of hla–dr5 (possibly drb1*1201) with the primary antiphospholipid syndrome in mexican patients
G Vargas-Alarcon, J Granados, C Bekker, J Alcocer-Varela, D Alarcón-Segovia 		Arthritis & Rheumatism 1995
Mannose-binding protein gene polymorphism in systemic lupus erythematosus
EJ Davies, N Snowden, MC Hillarby, D Carthy, DM Grennan, W Thomson, WE Ollier 		Arthritis & Rheumatism 1995
One Hundred Anti-Ro (SS-A) Antibody Positive Patients: A 10-Year Follow-Up
E Simmons-O'brien, S Chen, R Watson, C Antoni, M Petri, M Hochberg, MB Stevens, TT Provost 		Medicine 1995
Anticardiolipin antibodies in systemic lupus erythematosus: Clinical and laboratory correlations
M Abu-Shakra, DD Gladman, MB Urowitz, V Farewell 		The American Journal of Medicine 1995
Review: Genetics of systemic lupus erythematosus
PH Schur 		Lupus 1995
Association between HLA class II antigens and primary antiphospholipid syndrome from the South of Spain
MT Camps, MJ Cuadrado, P Ocón, A Alonso, A Gutierrez, M Guil, MI Grana, E Ramón 		Lupus 1995
HLA Antigens in Japanese Patients with Systemic Lupus Erythematosus
H Hashimoto, Y Nishimura, RP Dong, A Kimura, T Sasazuki, K Yamanaka, Y Tokano, A Murashima, K Kabasawa, S Hirose 		Scandinavian Journal of Rheumatology 1994
Neonatal lupus erythematosus. Report of serological and immunogenetic studies in twins discordant for congenital heart block
R Watson, J Scheel, M Petri, J Kan, T Provost, H Ratrie, N Callani 		British Journal of Dermatology 1994
Systemic Lupus Erythematosus: Considerations for a Genetic Approach
JB Harley, P Sheldon, B Neas, S Murphy, DJ Wallace, RH Scofield, TS Shaver, KL Moser 		Journal of Investigative Dermatology 1994
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
LA Casciola-Rosen, G Anhalt, A Rosen 		Journal of Experimental Medicine 1994
Common major histocompatibility complex class II markers in clinical variants of cicatricial pemphigoid
JJ Yunis, N Mobini, EJ Yunis, CA Alper, R Deulofeut, A Rodriguez, CS Foster, D Marcus-Bagley, RA Good, AR Ahmed 		Proceedings of the National Academy of Sciences 1994
Serologic Tests for Connective Tissue Diseases and the Primary Vasculitides
NB Warner 		Dermatologic Clinics 1994
24. Hämophilie-Symposion
I Scharrer, W Schramm 		1994
HISTOCOMPATIBILITY TYPING IN THE RHEUMATIC DISEASES
FC Arnett 		Rheumatic diseases clinics of North America 1994
Human leucocyte antigens (HLA) and rheumatic diseases: HLA class ii antigen-associated diseases
DP Singal, WW Buchanan 		Inflammopharmacology 1993
Contrasting molecular patterns of mhc class ii alleles associated with the anti-sm and anti-rnp precipitin autoantibodies in systemic lupus erythematosus
ML Olsen, FC Arnett, JD Reveille 		Arthritis & Rheumatism 1993
Different manifestations of the antiphospholipid antibody syndrome in a family with systemic lupus erythematosus
KP May, SG West, J Moulds, BL Kotzin 		Arthritis & Rheumatism 1993
Anti-Ro(SS-A) HLA-DR3-Positive Women: The Interrelationship Between Some ANA Negative, SS, SCLE, and NLE Mothers and SS/LE Overlap Female Patients
TT Provost, R Watson 		Journal of Investigative Dermatology 1993
Major histocompatibility complex associations with primary antiphospholipid syndrome
RA Asherson, DG Doherty, D Vergani, MA Khamashta, GR Hughes 		Arthritis & Rheumatism 1992
Genetic and immunological mechanisms in the pathogenesis of systemic lupus erythematosus
CG Drake, BL Kotzin 		Current Opinion in Immunology 1992
HLA-DPB1 alleles and autoantibody subsets in systemic lupus erythematosus, Sjögren's syndrome and progressive systemic sclerosis: A question of disease relevance
JD Reveille, J Brady, MM Clair, E Durban 		Tissue Antigens 1992
Genetic aspects of human lupus
FC Arnett 		Clinical Immunology and Immunopathology 1992
The Clinical Genetics of Lupus
RM Lewkonia 		Lupus 1992

Advertisement