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Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

S Ylä-Herttuala, … , J L Witztum, D Steinberg

S Ylä-Herttuala, … , J L Witztum, D Steinberg

Published April 1, 1991
Citation Information: J Clin Invest. 1991;87(4):1146-1152. https://doi.org/10.1172/JCI115111.

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Assay methods of modified lipoproteins in plasma Y Yamaguchi, M Kunitomo, J Haginaka	Journal of Chromatography B	2002
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Journal of Cardiovascular Risk S Kumbasar, I Dincer, F Ertas, S Gulec, C Erol, O Akyurek, M Kilickap, D Oral, E Sipahi, Y Laleli	Journal of Cardiovascular Risk	2001
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Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominant negative form of the macrophage scavenger receptor T P Hiltunen, P J Gough, D R Greaves, S Gordon, S Ylä-Herttuala	Atherosclerosis	2001
Interactions of nitric oxide-derived reactive nitrogen species with peroxidases and lipoxygenases MJ Coffey, B Coles, VB O'Donnell	Free Radical Research	2001
12/15-Lipoxygenase Translocation Enhances Site-specific Actin Polymerization in Macrophages Phagocytosing Apoptotic Cells YI Miller, MK Chang, CD Funk, JR Feramisco, JL Witztum	The Journal of biological chemistry	2001
Oxidized Low Density Lipoprotein Decreases Macrophage Expression of Scavenger Receptor B-I J Han, AC Nicholson, X Zhou, J Feng, AM Gotto, DP Hajjar	The Journal of biological chemistry	2001
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A Novel Form of Platelet-Type 12-Lipoxygenase mRNA in Human Vascular Smooth Muscle Cells R Limor, G Weisinger, S Gilad, E Knoll, O Sharon, A Jaffe, F Kohen, E Berger, B Lifschizt-Mercer, N Stern	Hypertension	2001
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Oxidized low-density lipoprotein is localized in the ventricles of hearts from patients with coronary heart disease C Ekmekcioglu, MR Mehrabi, HD Glogar, M Jucewicz, I Volf, PG Spieckermann	International Journal of Clinical & Laboratory Research	2000
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Dietary fish oil reduces intercellular adhesion molecule 1 and scavenger receptor expression on murine macrophages EA Miles, FA Wallace, PC Calder	Atherosclerosis	2000
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Antioxidant and Redox Regulation of Genes S Roy, CK Sen, A Gozin, V Andrieu, C Pasquier	Antioxidant and Redox Regulation of Genes	2000
Macrophage scavenger receptor class A: A multifunctional receptor in atherosclerosis MP de Winther, KW van Dijk, LM Havekes, MH Hofker	Arteriosclerosis, thrombosis, and vascular biology	2000
Regulation of Human 12/15-Lipoxygenase by Stat6-Dependent Transcription DJ Conrad, M Lu	American journal of respiratory cell and molecular biology	2000
Molecular Cloning of a Novel Scavenger Receptor for Oxidized Low Density Lipoprotein, SR-PSOX, on Macrophages T Shimaoka, N Kume, M Minami, K Hayashida, H Kataoka, T Kita, S Yonehara	The Journal of biological chemistry	2000
CD36, a Member of the Class B Scavenger Receptor Family, as a Receptor for Advanced Glycation End Products N Ohgami, R Nagai, M Ikemoto, H Arai, A Kuniyasu, S Horiuchi, H Nakayama	The Journal of biological chemistry	2000
Plasmin-mediated Macrophage Reversal of Low Density Lipoprotein Aggregation WY Zhang, I Ishii, HS Kruth	The Journal of biological chemistry	2000
Retrovirus-Mediated, Stable Scavenger-Receptor Gene Transfer Leads to Functional Endocytotic Receptor Expression, Foam Cell Formation, and Increased Susceptibility to Apoptosis in Rabbit Aortic Smooth Muscle Cells P Lehtolainen, M Takeya, S Ylä-Herttuala	Arteriosclerosis, thrombosis, and vascular biology	2000
Adenovirus-Mediated Gene Transfer of a Secreted Form of Human Macrophage Scavenger Receptor Inhibits Modified Low-Density Lipoprotein Degradation and Foam-Cell Formation in Macrophages J Laukkanen, P Lehtolainen, PJ Gough, DR Greaves, S Gordon, S Ylä-Herttuala	Circulation	2000
Oxidation of LDL by Myeloperoxidase and Reactive Nitrogen Species: Reaction Pathways and Antioxidant Protection AC Carr, MR McCall, B Frei	Arteriosclerosis, thrombosis, and vascular biology	2000
Overexpression of 15-Lipoxygenase in Vascular Endothelium Accelerates Early Atherosclerosis in LDL Receptor–Deficient Mice D Harats, A Shaish, J George, M Mulkins, H Kurihara, H Levkovitz, E Sigal	Arteriosclerosis, thrombosis, and vascular biology	2000
Reduced Atherosclerotic Lesions in Mice Deficient for Total or Macrophage-Specific Expression of Scavenger Receptor-A VR Babaev, LA Gleaves, KJ Carter, H Suzuki, T Kodama, S Fazio, MR Linton	Arteriosclerosis, thrombosis, and vascular biology	2000
Oxidative Stress and Vascular Disease JF Keaney		2000
Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice N Herijgers, MP de Winther, MV Eck, LM Havekes, MH Hofker, PM Hoogerbrugge, TJ Berkel	Journal of lipid research	2000
Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice T Cyrus, JL Witztum, DJ Rader, R Tangirala, S Fazio, MF Linton, CD Funk	Journal of Clinical Investigation	1999
The arachidonate 12/15 lipoxygenases DJ Conrad	Clinical Reviews in Allergy & Immunology	1999
Essential involvement of 12-lipoxygenase in regiospecific andstereospecific oxidation of low density lipoprotein by macrophages T Sakashita, Y Takahashi, T Kinoshita, T Yoshimoto	European Journal of Biochemistry	1999
Coronary artery blood how: Physiologic and pathophysiologic regulation L Feliciano, RJ Henning	Clinical Cardiology	1999
Complement activation by oxidatively modified low-density lipoproteins Wieland, Dorweiler, Bonitz, Lieser, Walev, Bhakdi	European Journal of Clinical Investigation	1999
High Expression of Human 15-Lipoxygenase Induces NF-κB-Mediated Expression of Vascular Cell Adhesion Molecule 1, Intercellular Adhesion Molecule 1, and T-Cell Adhesion on Human Endothelial Cells H Viita, CK Sen, S Roy, T Siljamäki, T Nikkari, S Ylä-Herttuala	Antioxidants & Redox Signaling	1999
15-Lipoxygenase-2 (15-LOX-2) Is Expressed in Benign Prostatic Epithelium and Reduced in Prostate Adenocarcinoma SB Shappell, WE Boeglin, SJ Olson, S Kasper, AR Brash	The American Journal of Pathology	1999
Endogenously produced lipoprotein lipase enhances the binding and cell association of native, mildly oxidized and moderately oxidized low-density lipoprotein in mouse peritoneal macrophages X Wang, J Greilberger, S Levak-Frank, R Zimmermann, R Zechner, G Jürgens	Biochemical Journal	1999
Microemulsion of seal oil markedly enhances the transfer of a hydrophobic radiopharmaceutical into acetylated low density lipoprotein W Xiao, L Wang, PJ Davis, H Liu	Lipids	1999
Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase I Kilty, A Logan, PJ Vickers	European Journal of Biochemistry	1999
Inhibitory effect of phospholipid hydroperoxide glutathione peroxidase on the activity of lipoxygenases and cyclooxygenases☆ HS Huang, CJ Chen, H Suzuki, S Yamamoto, WC Chang	Prostaglandins & Other Lipid Mediators	1999
The arachidonate 12/15 lipoxygenases: A review of tissue expression and biologic function DJ Conrad	Clinical Reviews in Allergy & Immunology	1999
Quantitative immunohistochemical detection of oxidized low density lipoprotein in the rabbit arterial wall Q Jave, DS Leake, PD Weinberg	Experimental and Molecular Pathology	1999
Oxidation of low density lipoprotein and plasma by 15-lipoxygenase and free radicals H Yamashita, A Nakamura, N Noguchi, E Niki, H Kühn	FEBS Letters	1999
Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions H Kataoka, N Kume, S Miyamoto, M Minami, H Moriwaki, T Murase, T Sawamura, T Masaki, N Hashimoto, T Kita	Circulation	1999
Analysis of Macrophage Scavenger Receptor (SR-A) Expression in Human Aortic Atherosclerotic Lesions PJ Gough, DR Greaves, H Suzuki, T Hakkinen, MO Hiltunen, M Turunen, SY Herttuala, T Kodama, S Gordon	Arteriosclerosis, thrombosis, and vascular biology	1999
15-Lipoxygenase Catalytically Consumes Nitric Oxide and Impairs Activation of Guanylate Cyclase VB ODonnell, KB Taylor, S Parthasarathy, H Kühn, D Koesling, A Friebe, A Bloodsworth, VM Darley-Usmar, BA Freeman	The Journal of biological chemistry	1999
Oxidative Stress as a Regulator of Gene Expression in the Vasculature C Kunsch, RM Medford	Circulation research	1999
Chemiluminescent Detection of Oxidants in Vascular Tissue: Lucigenin But Not Coelenterazine Enhances Superoxide Formation MM Tarpey, CR White, E Suarez, G Richardson, R Radi, BA Freeman	Circulation research	1999
Angiotensin II Type 1 Receptor–Mediated Peroxide Production in Human Macrophages Y Yanagitani, H Rakugi, A Okamura, K Moriguchi, S Takiuchi, M Ohishi, K Suzuki, J Higaki, T Ogihara	Hypertension	1999
Glycosylphosphatidylinositol-Specific Phospholipase D Is Expressed by Macrophages in Human Atherosclerosis and Colocalizes With Oxidation Epitopes KD OBrien, C Pineda, WS Chiu, R Bowen, MA Deeg	Circulation	1999
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4 KV Honn, LJ Marnett, S Nigam, EA Dennis		1999
Antithrombotics AC Uprichard, KP Gallagher		1999
Vascular Adhesion Molecules and Inflammation JD Pearson		1999
Lipoxygenases and their Metabolites S Nigam, CR Pace-Asciak		1999
Oxidants and antioxidants in atherogenesis: an appraisal S Parthasarathy, N Santanam, S Ramachandran, O Meilhac	Journal of lipid research	1999
13-(S)-Hydroxyoctadecadienoic acid (13-HODE) incorporation and conversion to novel products by endothelial cells X Fang, TL Kaduce, AA Spector	Journal of lipid research	1999
Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36 J Han, DP Hajjar, JM Tauras, AC Nicholson	Journal of lipid research	1999
Radiolabeled cholesteryl iopanoate/acetylated low density lipoprotein as a potential probe for visualization of early atherosclerotic lesions in rabbits W Xiao, L Wang, T Scott, R E Counsell, H Liu	Pharmaceutical Research	1999
Native low density lipoprotein-induced calcium transients trigger VCAM-1 and E-selectin expression in cultured human vascular endothelial cells S Allen, S Khan, F Al-Mohanna, P Batten, M Yacoub	Journal of Clinical Investigation	1998
Iron and LDL-oxidation in atherogenesis XM Yuan, UT Brunk	APMIS	1998
Colocalization of iron and ceroid in human atherosclerotic lesions FY Lee, TS Lee, CC Pan, AL Huang, LY Chau	Atherosclerosis	1998
Oxidized phospholipids as a new landmark in atherosclerosis H Itabe	Progress in Lipid Research	1998
Expression of lipoprotein receptors in atherosclerotic lesions TP Hiltunen, S Ylä-Herttuala	Atherosclerosis	1998
Characterization of atherosclerotic lesions in apo E3-leiden transgenic mice P Leppänen, JS Luoma, MH Hofker, LM Havekes, S Ylä-Herttuala	Atherosclerosis	1998
A specific 15-lipoxygenase inhibitor limits the progression and monocyte–macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit TM Bocan, WS Rosebury, SB Mueller, S Kuchera, K Welch, A Daugherty, JA Cornicelli	Atherosclerosis	1998
Uptake and catabolism of modified LDL in scavenger-receptor class A type I/II knock-out mice TJ van Berkel, AV Velzen, JK Kruijt, H Suzuki, T Kodama	Biochemical Journal	1998
Lipoproteins modulate expression of the macrophage scavenger receptor J Han, AC Nicholson	The American Journal of Pathology	1998
The iron ligand sphere geometry of mammalian 15-lipoxygenases RJ Kuban, R Wiesner, J Rathman, G Veldink, H Nolting, VA Solé, H Kühn	Biochemical Journal	1998
Inhibition of Mammalian 15-Lipoxygenase-Dependent Lipid Peroxidation in Low-Density Lipoprotein by Quercetin and Quercetin Monoglucosides EL da Silva, T Tsushida, J Terao	Archives of Biochemistry and Biophysics	1998
Lung Biology in Health and Disease: Amplification and Generation of Leukotrienes and Lipoxins by Transcellular Biosynthesis T Bigby, B Levy, C Serhan	Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential	1998
Bases celulares y moleculares de la acumulación de colesterol en la pared vascular y su contribución a la progresión de la lesión aterosclerótica V Llorente, L Badimon	Revista Española de Cardiología	1998
The Atherogenic Significance of an Elevated Plasma Triglyceride Level TC Ooi, DS Ooi	Critical Reviews in Clinical Laboratory Sciences	1998
Cell-mediated oxidation of LDL: Comparison of different cell types of the atherosclerotic lesion K Müller, KL Carpenter, MJ Mitchinson	Free Radical Research	1998
Expression of LDL Receptor, VLDL Receptor, LDL Receptor–Related Protein, and Scavenger Receptor in Rabbit Atherosclerotic Lesions: Marked Induction of Scavenger Receptor and VLDL Receptor Expression During Lesion Development TP Hiltunen, JS Luoma, T Nikkari, S Ylä-Herttuala	Circulation	1998
Expression of Extracellular SOD and iNOS in Macrophages and Smooth Muscle Cells in Human and Rabbit Atherosclerotic Lesions: Colocalization With Epitopes Characteristic of Oxidized LDL and Peroxynitrite-Modified Proteins JS Luoma, P Strålin, SL Marklund, TP Hiltunen, T Särkioja, S Ylä-Herttuala	Arteriosclerosis, thrombosis, and vascular biology	1998
Fat-Soluble Vitamins PJ Quinn, VE Kagan		1998
Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes U Kelavkar, S Wang, A Montero, J Murtagh, K Shah, K Badr	Molecular Biology Reports	1998
In vivo action of 15-lipoxygenase in early stages of human atherogenesis H Kühn, D Heydeck, I Hugou, C Gniwotta	Journal of Clinical Investigation	1997
Dynamics of oxidation of LDL and its inhibition by antioxidants E Niki, N Noguchi	BioFactors	1997
Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties SM Sendobry, JA Cornicelli, K Welch, T Bocan, B Tait, BK Trivedi, N Colbry, RD Dyer, SJ Feinmark, A Daugherty	British Journal of Pharmacology	1997
Increased Uptake of LDL by Oxidized Macrophages is the Result of an Initial Enhanced LDL Receptor Activity and of a Further Progressive Oxidation of LDL B Fuhrman, O Judith, S Keidar, L Ben-Yaish, M Kaplan, M Aviram	Free radical biology & medicine	1997
Low-density lipoprotein and oxidised low-density lipoprotein: Their role in the development of atherosclerosis CA Hamilton	Pharmacology & Therapeutics	1997
ASSOCIATION OF CORONARY PLAQUE RUPTURE AND ATHEROSCLEROTIC INFLAMMATION JJ Boyle	The Journal of Pathology	1997
The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity SA Gillmor, A Villaseñor, R Fletterick, E Sigal, MF Browner	Nature Structural Biology	1997
The Secondary Prevention of Coronary Artery Disease CN MD, AR MD, JS MD	The American Journal of Medicine	1997
Regulation of the synthesis of plasminogen activator inhibitor type 1 (PAI-1): pathogenetic mechanism of atherosclerosis in diabetes mellitus? TK Nordt, K Peter, W Kübler, C Bode	Fibrinolysis and Proteolysis	1997
Oxidation of Free Fatty Acids in Low Density Lipoprotein by 15-Lipoxygenase Stimulates Nonenzymic, α-Tocopherol-mediated Peroxidation of Cholesteryl Esters JM Upston, J Neužil, PK Witting, R Alleva, R Stocker	The Journal of biological chemistry	1997
Angiotensin II Increases Macrophage-mediated Modification of Low Density Lipoprotein via a Lipoxygenase-dependent Pathway KJ Scheidegger, S Butler, JL Witztum	The Journal of biological chemistry	1997
Fatty acid binding proteins reduce 15-lipoxygenase-induced oxygenation of linoleic acid and arachidonic acid BA Ek, DP Cistola, JA Hamilton, TL Kaduce, AA Spector	Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism	1997
Aggregated Low Density Lipoprotein Induces and Enters Surface-connected Compartments of Human Monocyte-Macrophages: UPTAKE OCCURS INDEPENDENTLY OF THE LOW DENSITY LIPOPROTEIN RECEPTOR WY Zhang, PM Gaynor, HS Kruth	The Journal of biological chemistry	1997
Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene MR Kritzik, AF Ziober, S Dicharry, DJ Conrad, E Sigal	Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression	1997
The Redox Status of Coenzyme Q10 in Total LDL as an Indicator of In Vivo Oxidative Modification: Studies on Subjects With Familial Combined Hyperlipidemia YB de Rijke, SJ Bredie, PN Demacker, JM Vogelaar, HL Hak-Lemmers, AF Stalenhoef	Arteriosclerosis, thrombosis, and vascular biology	1997
Cytokine Modulation of LDL Oxidation by Activated Human Monocytes VA Folcik, R Aamir, MK Cathcart	Arteriosclerosis, thrombosis, and vascular biology	1997
Lipoprotein Lipase Increases Lipoprotein Binding to the Artery Wall and Increases Endothelial Layer Permeability by Formation of Lipolysis Products JC Rutledge, MM Woo, AA Rezai, LK Curtiss, IJ Goldberg	Circulation research	1997
Scavenger Receptors are Present on Rabbit Aortic Endothelial Cells In Vivo A Daugherty, JA Cornicelli, K Welch, SM Sendobry, DL Rateri	Arteriosclerosis, thrombosis, and vascular biology	1997
Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3 KV Honn, LJ Marnett, S Nigam, RL Jones, PY Wong		1997
Extent of antioxidant protection of plasma LDL is not a predictor of the antiatherogenic effect of antioxidants J Fruebis, DA Bird, J Pattison, W Palinski	Journal of lipid research	1997
Characterization of a specific polyclonal antibody against 13-hydroperoxyoctadecadienoic acid-modified protein: formation of lipid hydroperoxide-modified apoB-100 in oxidized LDL Y Kato, Y Makino, T Osawa	Journal of lipid research	1997
Epidermal growth factor-stimulated production of esterified 13(S)-hydroxyoctadecadienoic acid is associated with tumor suppressor phenotype in Syrian hamster embryo fibroblasts R Hui, AL Everhart, WC Glasgow	Journal of lipid research	1997
Mechanisms of enhanced macrophage apoE secretion by oxidized LDL AA Cader, FM Steinberg, T Mazzone, A Chait	Journal of lipid research	1997
Increased ferritin gene expression in atherosclerotic lesions JH Pang, MJ Jiang, YL Chen, FW Wang, DL Wang, SH Chu, LY Chau	Journal of Clinical Investigation	1996
Human cytomegalovirus increases modified low density lipoprotein uptake and scavenger receptor mRNA expression in vascular smooth muscle cells YF Zhou, E Guetta, ZX Yu, T Finkel, SE Epstein	Journal of Clinical Investigation	1996
Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development J Shen, E Herderick, JF Cornhill, E Zsigmond, HS Kim, H Kühn, NV Guevara, L Chan	Journal of Clinical Investigation	1996
Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro(pero)xy-5Z,8Z,11Z,13E-eicosatetraenoic acid and 13-hydro(pero)xy-9Z,11E-octadecadienoic acid H Kühn	Progress in Lipid Research	1996
The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice CD Funk	Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism	1996
Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice X Zhou, S Stemme, GK Hansson	The American Journal of Pathology	1996
Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4 R Brinckmann, MS Topp, I Zalán, D Heydeck, P Ludwig, H Kühn, WE Berdel, JR Habenicht	Biochemical Journal	1996
Expression of very low density lipoprotein receptor mRNA in rabbit atherosclerotic lesions K Nakazato, T Ishibashi, J Shindo, M Shiomi, Y Maruyama	The American Journal of Pathology	1996
Expression of very low density lipoprotein receptor in the vascular wall. Analysis of human tissues by in situ hybridization and immunohistochemistry HA Multhaupt, ME Gåfvels, K Kariko, H Jin, C Arenas-Elliot, BI Goldman, JF 3rd, B Angelin, MJ Warhol, KR McCrae	The American Journal of Pathology	1996
Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages N Umetani	Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism	1996
Enhanced scavenger receptor expression in monocyte-macrophages in dialysis patients M Ando, I Lundkvist, J Bergström, B Lindholm	Kidney International	1996
Dual effects of oxidized low-density lipoprotein on ommune-stimulated nitric oxide and prostaglandin release in macrophages KE Matthys, CE van Hove, PG Jorens, M Rosseneu, B Marescau, AG Herman, H Bult	European Journal of Pharmacology	1996
Cellular mechanisms in the development of atherosclerosis ME Rosenfeld	Diabetes Research and Clinical Practice	1996
PATHOPHYSIOLOGY OF PLAQUE RUPTURE AND THE CONCEPT OF PLAQUE STABILIZATION PK Shah	Cardiology Clinics	1996
Oxidation of Low Density Lipoproteins Greatly Enhances Their Association with Lipoprotein Lipase Anchored to Endothelial Cell Matrix BJ Auerbach, CL Bisgaier, J Wölle, U Saxena	The Journal of biological chemistry	1996
Role of Hydroperoxyeicosatetraenoic Acids in Oxidative Stress-induced Activating Protein 1 (AP-1) Activity GN Rao, WC Glasgow, TE Eling, MS Runge	The Journal of biological chemistry	1996
Disruption of 12/15-Lipoxygenase Expression in Peritoneal Macrophages: ENHANCED UTILIZATION OF THE 5-LIPOXYGENASE PATHWAY AND DIMINISHED OXIDATION OF LOW DENSITY LIPOPROTEIN D Sun, CD Funk	The Journal of biological chemistry	1996
Oxidation-Specific Epitopes in Human Coronary Atherosclerosis Are Not Limited to Oxidized Low-Density Lipoprotein KD O'Brien, CE Alpers, JE Hokanson, S Wang, A Chait	Circulation	1996
Neovascular Expression of E-Selectin, Intercellular Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Human Atherosclerosis and Their Relation to Intimal Leukocyte Content KD OBrien, TO McDonald, A Chait, MD Allen, CE Alpers	Circulation	1996
Human Monocytes/Macrophages Release TNF-α in Response to Ox-LDL S Jovinge, MP Ares, B Kallin, J Nilsson	Arteriosclerosis, thrombosis, and vascular biology	1996
Mouse Peritoneal Macrophages Contain Abundant ω-6 Lipoxygenase Activity That Is Independent of Interleukin-4 JA Cornicelli, K Welch, B Auerbach, SJ Feinmark, A Daugherty	Arteriosclerosis, thrombosis, and vascular biology	1996
Drugs Affecting Lipid Metabolism AM Gotto, R Paoletti, LC Smith, AL Catapano, AS Jackson		1996
Endocrinology of the Vasculature JR Sowers		1996
The Selenoenzyme Phospholipid Hydroperoxide Glutathione Peroxidase Controls the Activity of the 15-Lipoxygenase with Complex Substrates and Preserves the Specificity of the Oxygenation Products K Schnurr, J Belkner, F Ursini, T Schewe, H Kühn	The Journal of biological chemistry	1996
Oxidation of LDL by recombinant human 15-lipoxygenase: evidence for alpha-tocopherol-dependent oxidation of esterified core and surface lipids JM Upston, J Neuzil, R Stocker	Journal of lipid research	1996
Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines H Li, MW Freeman, P Libby	Journal of Clinical Investigation	1995
Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells BV Khan, SS Parthasarathy, RW Alexander, RM Medford	Journal of Clinical Investigation	1995
A chemotactic S100 peptide enhances scavenger receptor and Mac-1 expression and cholesteryl ester accumulation in murine peritoneal macrophages in vivo W Lau, JM Devery, CL Geczy	Journal of Clinical Investigation	1995
Malondialdehyde-modified low density lipoproteins in patients with atherosclerotic disease P Holvoet, G Perez, Z Zhao, E Brouwers, H Bernar, D Collen	Journal of Clinical Investigation	1995
Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein S Ylä-Herttuala, J Luoma, H Viita, T Hiltunen, T Sisto, T Nikkari	Journal of Clinical Investigation	1995
Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques VA Folcik, RA Nivar-Aristy, LP Krajewski, MK Cathcart	Journal of Clinical Investigation	1995
Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells GN Rao, RW Alexander, MS Runge	Journal of Clinical Investigation	1995
Nitric Oxide RA Schroeder, PC Kuo	Anesthesia & Analgesia	1995
15-Lipoxygenase expression in smooth muscle cells from atherosclerotic rabbit aortas I Hugou, P Blin, J Henri, D Daret, J Larrue	Atherosclerosis	1995
Arachidonate 15-hpoxygenase H Kühn, BJ Thiele	Journal of Lipid Mediators and Cell Signalling	1995
Murine macrophage scavenger receptor: in vivo expression and function as receptor for macrophage adhesion in lymphoid and non-lymphoid organs DA Hughes, IP Fraser, S Gordon	European Journal of Immunology	1995
Cloning and characterization of a murine macrophage lipoxygenase J Freire-Moar, A Alavi-Nassab, M Ng, M Mulkins, E Sigal	Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism	1995
Effect of Modified LDL on the Release of NO and PGI2 from Rat Peritoneal Macrophages H Morio, H Saito, A Hirai, Y Tamura, S Yoshida	Journal of Atherosclerosis and Thrombosis	1995
Metal Ion Release from Mechanically-Disrupted Human Arterial Wall. Implications for the Development of Atherosclerosis PJ Evans, C Smith, MJ Mitchinson, B Halliwell	Free Radical Research	1995
Antioxidants and Cardiovascular Disease KR Bruckdorfer		1995
Identification of a Specific Methionine in Mammalian 15-Lipoxygenase Which Is Oxygenated by the Enzyme Product 13-HPODE: Dissociation of Sulfoxide Formation from Self-Inactivation QF Gan, GL Witkop, DL Sloane, KM Straub, E Sigal	Biochemistry	1995
A possible role for 15-lipoxygenase in atherogenesis D Harats, MA Mulkins, E Sigal	Trends in Cardiovascular Medicine	1995
Enhanced Levels of Lipoperoxides in Low Density Lipoprotein Incubated with Murine Fibroblasts Expressing High Levels of Human 15-Lipoxygenase DJ Benz, M Mol, M Ezaki, N Mori-Ito, I Zelán, A Miyanohara, T Friedmann, S Parthasarathy, D Steinberg, JL Witztum	The Journal of biological chemistry	1995
Induction of 15-Lipoxygenase mRNA and Protein in Early Atherosclerotic Lesions T Hiltunen, J Luoma, T Nikkari, S Ylä-Herttuala	Circulation	1995
Generation, Characterization, and Histochemical Application of Monoclonal Antibodies Selectively Recognizing Oxidatively Modified ApoB-Containing Serum Lipoproteins A Hammer, G Kager, G Dohr, H Rabl, I Ghassempur, G Jürgens	Arteriosclerosis, thrombosis, and vascular biology	1995
Immunohistochemical Demonstration of 15-Lipoxygenase in Transplant Coronary Artery Disease S Ravalli, CC Marboe, VD DAgati, RE Michler, E Sigal, PJ Cannon	Arteriosclerosis, thrombosis, and vascular biology	1995
Inhibition of Hypercholesterolemia-Induced Atherosclerosis in the Nonhuman Primate by Probucol: II. Cellular Composition and Proliferation MY Chang, M Sasahara, A Chait, EW Raines, R Ross	Arteriosclerosis, thrombosis, and vascular biology	1995
Mast Cell Granule Remnants Carry LDL Into Smooth Muscle Cells of the Synthetic Phenotype and Induce Their Conversion Into Foam Cells Y Wang, KA Lindstedt, PT Kovanen	Arteriosclerosis, thrombosis, and vascular biology	1995
Tissue Factor Pathway Inhibitor Activity Associated With LDL Is Inactivated by Cell- and Copper-Mediated Oxidation P Lesnik, C Dentan, A Vonica, M Moreau, MJ Chapman	Arteriosclerosis, thrombosis, and vascular biology	1995
Oxidized Low-Density Lipoproteins Facilitate Leukocyte Adhesion to Aortic Intima Without Affecting Endothelium-Dependent Relaxation: Role of P-Selectin A Mehta, B Yang, S Khan, JB Hendricks, C Stephen, JL Mehta	Arteriosclerosis, thrombosis, and vascular biology	1995
Coronary Plaque Disruption E Falk, PK Shah, V Fuster	Circulation	1995
A Leukocyte Type of 12-Lipoxygenase Is Expressed in Human Vascular and Mononuclear Cells: Evidence for Upregulation by Angiotensin II JA Kim, JL Gu, R Natarajan, JA Berliner, JL Nadler	Arteriosclerosis, thrombosis, and vascular biology	1995
Analysis of Free Radicals in Biological Systems AE Favier, J Cadet, B Kalyanaraman, M Fontecave, JL Pierre		1995
Stimulation with a monoclonal antibody (mAb4E4) of scavenger receptor-mediated uptake of chemically modified low density lipoproteins by THP-1-derived macrophages enhances foam cell generation P Holvoet, G Perez, H Bernar, E Brouwers, B Vanloo, M Rosseneu, D Collen	Journal of Clinical Investigation	1994
Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and scavenger receptor in human atherosclerotic lesions J Luoma, T Hiltunen, T Särkioja, SK Moestrup, J Gliemann, T Kodama, T Nikkari, S Ylä-Herttuala	Journal of Clinical Investigation	1994
Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. I. Is the extent of atherosclerosis related to resistance of LDL to oxidation? M Sasahara, EW Raines, A Chait, TE Carew, D Steinberg, PW Wahl, R Ross	Journal of Clinical Investigation	1994
A comparison of the antiatherogenic effects of probucol and of a structural analogue of probucol in low density lipoprotein receptor-deficient rabbits J Fruebis, D Steinberg, HA Dresel, TE Carew	Journal of Clinical Investigation	1994
Oxidation of low density lipoprotein by mesangial cells may promote glomerular injury DC Wheeler, RS Chana, N Topley, MM Petersen, M Davies, JD Williams	Kidney International	1994
In vivo to in vitro to in vivo-utilization of new in situ techniques for the study of atherosclerosis ME Rosenfeld	Journal of Vascular Surgery	1994
Enhanced LDL oxidation by murine macrophage foam cells and their failure to secrete nitric oxide EJ Bolton, W Jessup, KK Stanley, RT Dean	Atherosclerosis	1994
Oxidation, Lipoxygenase, and Atherogenesis E Sigal, CW Laughton, MA Mulkins	Annals of the New York Academy of Sciences	1994
Involvement of 15-lipoxygenase in early stages of atherogenesis H Kühn, J Belkner, S Zaiss, T Fährenklemper, S Wohlfeil	Journal of Experimental Medicine	1994
Why are low-density lipoproteins atherogenic? SG Young, S Parthasarathy	The Western journal of medicine	1994
7 beta-hydroperoxycholest-5-en-3 beta-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein GM Chisolm, G Ma, KC Irwin, LL Martin, KG Gunderson, LF Linberg, DW Morel, PE DiCorleto	Proceedings of the National Academy of Sciences	1994
Binding characteristics of scavenger receptors on liver endothelial and Kupffer cells for modified low-density lipoproteins YB de Rijke, EA Biessen, CJ Vogelezang, TJ van Berkel	Biochemical Journal	1994
Low density lipoprotein uptake by macrophages in multiple sclerosis plaques: implications for pathogenesis J Newcombe, H Li, ML Cuzner	Neuropathology and Applied Neurobiology	1994
Advances in Pharmacology B Drenger, Y Ginosar, Y Gozal	Advances in Pharmacology	1994
Gene targeting and generation of mutant mice for studies of cell-extracellular matrix interactions KL Philpott, JL Viney, G Kay, S Rastan, EM Gardiner, S Chae, AC Hayday, MJ Owen	Methods in enzymology	1994
Lipid Mediators JR Vane, RM Botting	Lipid Mediators	1994
Natural Antioxidants in Human Health and Disease M Levine, KR Dhariwal, Y Wang, JB Park, RW Welch	Natural Antioxidants in Human Health and Disease	1994
Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL S Ylä-Herttuala, W Palinski, SW Butler, S Picard, D Steinberg, JL Witztum	Arteriosclerosis Thrombosis and Vascular Biology	1994
Inhibition of inducible nitric oxide synthase in macrophages by oxidized low-density lipoproteins X Yang, B Cai, RR Sciacca, PJ Cannon	Circulation research	1994
A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association HC Stary, AB Chandler, S Glagov, JR Guyton, W Insull, ME Rosenfeld, SA Schaffer, CJ Schwartz, WD Wagner, RW Wissler	Circulation	1994
Differential expression of scavenger receptor isoforms during monocyte-macrophage differentiation and foam cell formation Y Geng, T Kodama, GK Hansson	Arteriosclerosis Thrombosis and Vascular Biology	1994
Principles and Treatment of Lipoprotein Disorders G Schettler, AJ Habenicht		1994
Free Radicals in Diagnostic Medicine D Armstrong		1994
Vascular Diagnostics P Lanzer, J Rösch		1994
Rat liver Kupffer and endothelial cells express different binding proteins for modified low density lipoproteins. Kupffer cells express a 95-kDa membrane protein as a specific binding site for oxidized low density lipoproteins YB de Rijke, TJ van Berkel	The Journal of biological chemistry	1994
Modulation of the beta-adrenergic response of cardiomyocytes by specific lipoxygenase products involves their incorporation into phosphatidylinositol and activation of protein kinase C G Wallukat, R Morwinski, H Kühn	The Journal of biological chemistry	1994
Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes GM Nassar, JD Morrow, LJ nd, FG Lakkis, KF Badr	The Journal of biological chemistry	1994
Macrophage-mediated oxidation of extracellular low density lipoprotein requires an initial binding of the lipoprotein to its receptor M Aviram, M Rosenblat	Journal of lipid research	1994
Lipoproteins and their functions AJ Habenicht, U Janen-Timmen, R Ziegler, G Schettler	The Clinical Investigator	1994
Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes HF McMurray, S Parthasarathy, D Steinberg	Journal of Clinical Investigation	1993
Modified forms of low-density lipoprotein and atherosclerosis D Steinberg	Journal of Internal Medicine	1993
Different expression of modified low density lipoprotein receptors in rabbit peritoneal macrophages and Kupffer cells Y Ueda, H Arai, A Kawashima, Y Nagano, M Cho, M Tanaka, T Kita	Atherosclerosis	1993
Flow cytometric measurement of ceroid accumulation in macrophages JV Hunt, KL Carpenter, MA Bottoms, NP Carter, CE Marchant, MJ Mitchinson	Atherosclerosis	1993
Oxygenation of lipoproteins by mammalian lipoxygenases J BELKNER, R WIESNER, J RATHMAN, J BARNETT, E SIGAL, H KUHN	European Journal of Biochemistry	1993
Overexpression, purification and characterization of human recombinant 15-lipoxygenase H Kühn, J Barnett, D Grunberger, P Baecker, J Chow, B Nguyen, H Bursztyn-Pettegrew, H Chan, E Sigal	Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism	1993
Interleukin-1 increases 15-hydroxyeicosatetraenoic acid formation in cultured human endothelial cells S López, L Vila, F Breviario, C Castellarnau	Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism	1993
Charged collagen structure mediates the recognition of negatively charged macromolecules by macrophage scavenger receptors N Platt, S Gordon	The Journal of biological chemistry	1993
Inhibition of copper-mediated oxidation of LDL by rat serosal mast cells. A novel cellular protective mechanism involving proteolysis of the substrate under oxidative stress KA Lindstedt, JO Kokkonen, PT Kovanen	Arteriosclerosis Thrombosis and Vascular Biology	1993
Immunostaining of human autopsy aortas with antibodies to modified apolipoprotein B and apoprotein(a) G Jürgens, Q Chen, H Esterbauer, S Mair, G Ledinski, HP Dinges	Arteriosclerosis Thrombosis and Vascular Biology	1993
Nutrition and Immunology DM Klurfeld		1993
Presence of foam cells containing oxidised low density lipoprotein in the synovial membrane from patients with rheumatoid arthritis PG Winyard, F Tatzber, H Esterbauer, ML Kus, DR Blake, CJ Morris	Annals of the rheumatic diseases	1993
Assessment of 5-lipoxygenase involvement in human monocyte-mediated LDL oxidation VA Folcik, MK Cathcart	Journal of lipid research	1993
Inhibition of macrophage-mediated low density lipoprotein oxidation by stimulated rat serosal mast cells KA Lindstedt	The Journal of biological chemistry	1993
Molecular flypaper, host defense, and atherosclerosis. Structure, binding properties, and functions of macrophage scavenger receptors M Krieger, S Acton, J Ashkenas, A Pearson, M Penman, D Resnick	The Journal of biological chemistry	1993
Interferon-gamma inhibits scavenger receptor expression and foam cell formation in human monocyte-derived macrophages YJ Geng, GK Hansson	Journal of Clinical Investigation	1992
Rabbit aortic smooth muscle cells express inducible macrophage scavenger receptor messenger RNA that is absent from endothelial cells PE Bickel, MW Freeman	Journal of Clinical Investigation	1992
Free radicals, lipoproteins and cardiovascular dysfunction C Rice-Evans, KR Bruckdorfer	Molecular Aspects of Medicine	1992
Role of oxidized low density lipoprotein in atherogenesis S Parthasarathy, SM Rankin	Progress in Lipid Research	1992
Cellular oxidative modification of low density lipoprotein does not require lipoxygenases CP Sparrow, J Olszewski	Proceedings of the National Academy of Sciences	1992
Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions C Smith, MJ Mitchinson, OI Aruoma, B Halliwell	Biochemical Journal	1992
Macrophage colony-stimulating factor mRNA and protein in atherosclerotic lesions of rabbits and humans ME Rosenfeld, S Ylä-Herttuala, BA Lipton, VA Ord, JL Witztum, D Steinberg	The American Journal of Pathology	1992
Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase DJ Conrad, H Kuhn, M Mulkins, E Highland, E Sigal	Proceedings of the National Academy of Sciences	1992
Molecular flypaper and atherosclerosis: structure of the macrophage scavenger receptor M Krieger	Trends in Biochemical Sciences	1992
Mammalian lipoxygenases: molecular structures and functions S Yamamoto	Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism	1992
Epithelial Cells as Modulators JA Nadel	Chest	1992
The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoprotein W Jessup, D Mohr, SP Gieseg, RT Dean, R Stocker	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	1992
Autoradiographic analysis of the distribution of 125I-tyramine-cellobiose-LDL in atherosclerotic lesions of the WHHL rabbit ME Rosenfeld, TE Carew, E von Hodenberg, RC Pittman, R Ross, D Steinberg	Arteriosclerosis Thrombosis and Vascular Biology	1992
Monoclonal antibodies against LDL further enhance macrophage uptake of LDL aggregates JC Khoo, E Miller, F Pio, D Steinberg, JL Witztum	Arteriosclerosis Thrombosis and Vascular Biology	1992
Modified low density lipoprotein stimulates nitric oxide synthesis in vascular smooth muscle cells T Inoue, K Fukuo, R Morita, S Morimoto, T Ogihara	The Japanese Journal of Pharmacology	1992
Role of oxidized low density lipoprotein in atherogenesis JL Witztum, D Steinberg	Journal of Clinical Investigation	1991
Novel atherogenic, oxidative modification of low-density lipoprotein S Parthasarathy	Diabetes / Metabolism Reviews	1991
Macrophages and Oxidized Low Density Lipoproteins in the Pathogenesis of Atherosclerosis S Ylä-Herttuala	Annals of Medicine	1991
Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine H Drexler, AM Zeiher, K Meinzer, H Just	The Lancet	1991
Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions S Ylä-Herttuala, BA Lipton, ME Rosenfeld, IJ Goldberg, D Steinberg, JL Witztum	Proceedings of the National Academy of Sciences	1991
Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions S Ylä-Herttuala, BA Lipton, ME Rosenfeld, T Särkioja, T Yoshimura, EJ Leonard, JL Witztum, D Steinberg	Proceedings of the National Academy of Sciences	1991
Oxidized LDL affects multiple atherogenic cellular responses ME Rosenfeld	Circulation	1991
Transforming growth factor-beta 1 inhibits scavenger receptor activity in THP-1 human macrophages LA Bottalico, RE Wager, LB Agellon, RK Assoian, I Tabas	The Journal of biological chemistry	1991
Progress in Nucleic Acid Research and Molecular Biology FS Collins, SM Weissman	Progress in nucleic acid research and molecular biology	1984

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