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Citations to this article

Disparate effects of interferon-gamma and tumor necrosis factor-alpha on early neutrophil respiratory burst and fungicidal responses to Candida albicans hyphae in vitro.
R D Diamond, … , C A Lyman, D R Wysong
R D Diamond, … , C A Lyman, D R Wysong
Published February 1, 1991
Citation Information: J Clin Invest. 1991;87(2):711-720. https://doi.org/10.1172/JCI115050.
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Research Article

Disparate effects of interferon-gamma and tumor necrosis factor-alpha on early neutrophil respiratory burst and fungicidal responses to Candida albicans hyphae in vitro.

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Abstract

We examined effects of priming with recombinant human interferon-gamma (IFN) or tumor necrosis factor-alpha (TNF) on neutrophil responses to Candida albicans hyphae. Both cytokines increased early superoxide generation after hyphal stimulation. The more pronounced effects of TNF were accompanied by an augmented surface membrane depolarization rate and were insensitive to both pertussis toxin and calcium ion chelation, but were negated by concomitant incubation with puromycin or cycloheximide during priming. IFN augmented hyphal killing despite its only minor enhancement of early respiratory burst responses, but TNF reduced neutrophil fungicidal activity to nearly 40% below those by unprimed control cells even though it enhanced early superoxide responses more dramatically. Though TNF-primed neutrophils killed hyphae at normal initial rates, IFN-primed or even unprimed cells manifested more fungicidal sustained activity. These disparate consequences of cytokine priming on hyphal destruction were paralleled by differences in late generation of potentially candidacidal oxidants, hydrogen peroxide, and hypochlorous acid. IFN added during priming failed to correct TNF-associated functional defects in neutrophil anti-Candida responses. Thus, augmentation of early respiratory burst responses to oxidant-sensitive organisms need not necessarily reflect concomitant salutary effects on microbicidal activity.

Authors

R D Diamond, C A Lyman, D R Wysong

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Total citations by year

Year: 2025 2023 2021 2020 2017 2016 2014 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 1999 1998 1997 1996 1995 1994 1993 1992 1991 Total
Citations: 2 1 2 1 1 1 1 2 1 2 6 2 2 2 1 2 2 4 8 4 6 3 5 10 3 1 75
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2007 (6)

Title and authors Publication Year
The Neutrophil
Dockrell DH, McGrath EE, Whyte MK, Sabroe I
2007
Variable Number of Tandem Repeats of TNF Receptor Type 2 Promoter as Genetic Biomarker of Susceptibility to Develop Invasive Pulmonary Aspergillosis
J Sainz, E Pérez, L Hassan, A Moratalla, A Romero, MD Collado, M Jurado
Human Immunology 2007
Paracoccidioides brasiliensiskilling by IFN-γ, TNF-α and GM-CSF activated human neutrophils: role for oxygen metabolites
DR Rodrigues, LA Dias-Melicio, SA Calvi, MT Peraçoli, AM Soares
Medical Mycology 2007
Protein synthesis inhibition as a potential strategy for metabolic down-regulation
MC Evans, RF Diegelmann, RW Barbee, MH Tiba, E Edwards, S Sreedhar, KR Ward
Resuscitation 2007
Effect of Interleukin-10 on the Paracoccidioides brasiliensis Killing by Gamma-Interferon Activated Human Neutrophils
DL Costa, LA Dias-Melicio, MJ Acorci, AP Bordon, EG Tavian, MT Peraçoli, AM de Soares
Microbiology and Immunology 2007
Immunology of Fungal Infections
GD Brown, MG Netea
2007

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