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Citations to this article

Enhanced production of neutrophil-activating peptide-1/interleukin-8 in rheumatoid arthritis.
M Seitz, … , N Gerber, M Baggiolini
M Seitz, … , N Gerber, M Baggiolini
Published February 1, 1991
Citation Information: J Clin Invest. 1991;87(2):463-469. https://doi.org/10.1172/JCI115018.
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Enhanced production of neutrophil-activating peptide-1/interleukin-8 in rheumatoid arthritis.

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Abstract

Production of the neutrophil-activating peptide (NAP)-1/IL-8 by mononuclear phagocytes from patients with RA and from control subjects was studied under various conditions. Mononuclear cells from bone marrow (BMMC), PBMC, and synovial fluid (SFMC) were cultured for up to 48 h in the absence or presence of Escherichia coli LPS, different interleukins, interferon-gamma, zymosan, or immune complexes, and the neutrophil-stimulating activity released into the culture medium was determined. As shown by neutralization with an antiserum raised against human recombinant NAP-1/IL-8, over 90% of this activity could be attributed to NAP-1/IL-8. In unstimulated mononuclear cells from control individuals and BMMC from RA patients, the production of NAP-1/IL-8 was very low and was enhanced moderately by stimulation with LPS. By contrast, the spontaneous production of NAP-1/IL-8 was 3- to 10-fold higher in PBMC and even much higher in SFMC from RA patients. In all instances, the yield of NAP-1/IL-8 could be enhanced by stimulation in culture. In addition to LPS, rheumatoid factor-containing immune complexes, zymosan, and IL-1 were highly effective in inducing NAP-1/IL-8 production, while IL-3, GM-CSF, tumor necrosis factor (TNF), and IL-2 were somewhat less potent. An inhibitory effect was obtained with IFN-gamma, which significantly decreased the spontaneous NAP-1/IL-8 release from SFMC and the IL-1- and LPS-induced NAP-1/IL-8 from RA and control PBMC. Inhibition was also observed with glucocorticoids. The production of NAP-1/IL-8 was markedly reduced by dexamethasone in phagocytosis-stimulated PBMC, and almost totally inhibited in SFMC obtained from joints after intraarticular administration of betamethasone. By contrast, the cyclooxygenase inhibitor, indomethacin, tended to increase the NAP-1/IL-8 yield from PBMC in culture.

Authors

M Seitz, B Dewald, N Gerber, M Baggiolini

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Seminars in Arthritis and Rheumatism 1996
ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
M Feldmann, FM Brennan, RN Maini
Annual Review of Immunology 1996
Opposite effects of interleukin-13 and interleukin-12 on the release of inflammatory cytokines, cytokine inhibitors and prostaglandin E from synovial fibroblasts and blood mononuclear cells
M Seitz, P Loetscher, B Dewald, H Towbin, M Baggiolini
European Journal of Immunology 1996
Interleukin-8 in Hodgkin's disease. Preferential expression by reactive cells and association with neutrophil density
HD Foss, H Herbst, S Gottstein, G Demel, I Araujó, H Stein
The American Journal of Pathology 1996
Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes
M Loetscher, B Gerber, P Loetscher, SA Jones, L Piali, I Clark-Lewis, M Baggiolini, B Moser
Journal of Experimental Medicine 1996
Design and evaluation of small peptides mapping the exposed surface of IL-8
SK Thompson, DF Veber, AJ Jurewicz, CE Peishoff, JM Lee, JR White
International Journal of Peptide and Protein Research 1996
Selective inhibition of interleukin-1β gene expression in activated RAW 264.7 macrophages by interferon-γ
CS Chujor, L Klein, C Lam
European Journal of Immunology 1996
The inhibitory effect of pentamidine on the production of chemotactic cytokines by in vitro stimulated human blood cells
J Wauwe, F Aerts, H Genechten, H Blockx, W Deleersnijder, H Walter
Inflammation Research 1996
Chemiluminescence Responses and Chemotaxis of Monocytes from Patients with Early Rheumatoid Arthritis
H Repo, L Paimela, M Leirisalo-Repo
Scandinavian Journal of Rheumatology 1996
Essentials of Mucosal Immunology
DK Podolsky
Essentials of Mucosal Immunology 1996
The Role of Interleukin-8 in Patients with Hematologic Diseases
H UENO, K HINO, K YAMADA, S YAMAMORI, S TOMOYASU, N TSURUOKA
The Showa University Journal of Medical Sciences 1996
Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis:
EJ Miller, AB Cohen, MA Matthay
Critical Care Medicine 1996
Interleukin 8: cells of origin in inflammatory bowel disease
MC Grimm, SK Elsbury, P Pavli, WF Doe
Gut 1996
Interleukin-1 alpha, interleukin-8 and interferon-alpha levels in gingival crevicular fluid
A Mathur, B Michalowicz, M Castillo, D Aeppll
Journal of Periodontal Research 1996
Roles of proinflammatory and anti-inflammatory cytokines in pathophysiology of bacterial meningitis and effect of adjunctive therapy
AM van Furth, JJ Roord, R van Furth
Infection and immunity 1996
The inhibitory effect of pentamidine on the production of chemotactic cytokines by in vitro stimulated human blood cells
JV Wauwe, F Aerts, HV Genechten, H Blockx, W Deleersnijder, H Walter
Inflammation Research 1996
Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis
T Kasama, RM Strieter, NW Lukacs, PM Lincoln, MD Burdick, SL Kunkel
Journal of Clinical Investigation 1995
Upregulated expression of IL-4 receptors and increased levels of IL-4 in rheumatoid arthritis patients
D Rivas, L Mozo, J Zamorano, A Gayo, JC Torre-Alonso, A Rodriguez, C Gutiérrez
Journal of Autoimmunity 1995
A review on the Strategies for the Development and Application of New Anti-arthritic Agents
AJ Lewis, AF Keft
Immunopharmacology and Immunotoxicology 1995
An Anti-Interleukin 8 Monoclonal Antibody That Interferes with the Binding of Interleukin 8 to Cellular Receptors and the Activation of Human Blood Neutrophils
A Kurdowska, E Miller, A Cohen
Hybridoma 1995
Production of TNF by Monocytes of Patients with Early Rheumatoid Arthritis is Increased
M Leirisalo-Repo, L Paimela, M Jäätteä, S Koskimies, H Repo
Scandinavian Journal of Rheumatology 1995
Interleukin-8 gene expression in the human colon epithelial cell line, HT-29, exposed to Entamoeba histolytica
JM Kim, HC Jung, K Im, YJ Cho, CY Kim
The Korean Journal of Parasitology 1995
Interleukin 8 and mast cell-generated tumor necrosis factor-? in neutrophil recruitment
Y Zhang, BF Ramos, B Jakschik, MP Baganoff, CL Deppeler, DM Meyer, DL Widomski, DJ Fretland, MA Bolanowski
Inflammation 1995
Indomethacin-induced gastric injury and leukocyte adherence in arthritic versus healthy rats
DM McCafferty, DN Granger, JL Wallace
Gastroenterology 1995
Neutrophil accumulation and activation by homologous IL-8 in rabbits. IL-8 induces destruction of cartilage and production of IL-1 and IL-1 receptor antagonist in vivo
RC Hoch, IU Schraufstätter, CG Cochrane
Journal of immunology (Baltimore, Md. : 1950) 1995
Aproximación inmunológica a las vasculitis sistémicas y pulmonares
JA Bermúdez
Archivos de Bronconeumología 1995
Chemokines, a Family of Chemotactic Cytokines
DT Groves, Y Jiang
Critical Reviews in Oral Biology & Medicine 1995
Identification and characterization of rhesus macaque interleukin-8
JC Minnerly, MP Baganoff, CL Deppeler, BT Keller, SR Rapp, DL Widomski, DJ Fretland, MA Bolanowski
Inflammation 1995
Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritis
AE Koch, SL Kunkel, LA Harlow, DD Mazarakis, GK Haines, MD Burdick, RM Pope, RM Strieter
Journal of Clinical Investigation 1994
Long-term impaired neutrophil migration in mice overexpressing human interleukin-8
WS Simonet, TM Hughes, HQ Nguyen, LD Trebasky, DM Danilenko, ES Medlock
Journal of Clinical Investigation 1994
Differential expression of two major cytokines produced by neutrophils, interleukin-8 and the interleukin-1 receptor antagonist, in neutrophils isolated from the synovial fluid and peripheral blood of patients with rheumatoid arthritis
AD Beaulieu, SR Mccoll
Arthritis & Rheumatism 1994
Monocyte chemoattractant protein 1 and interleukin 8 production by rheumatoid synoviocytes. Effects of anti-rheumatic drugs
P Loetscher, B Dewald, M Baggiolini, M Seitz
Cytokine 1994
Interaction between oncostatin M, interleukin 1 and prostaglandin E2 in induction of IL-6 expression in human fibroblasts
CD Richards, A Agro
Cytokine 1994
Cytokines and Acute Phase Proteins in Rheumatoid Arthritis
GW Duff
Scandinavian Journal of Rheumatology 1994
Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation
L Mazzucchelli, C Hauser, K Zgraggen, H Wagner, M Hess, JA Laissue, C Mueller
The American Journal of Pathology 1994
Localized expression of mRNA for phagocyte-specific chemotactic cytokines in human periodontal infections
MS Tonetti, MA Imboden, L Gerber, NP Lang, J Laissue, C Mueller
Infection and immunity 1994
Molecular cloning and expression of canine interleukin 8 cDNA
Y Matsumoto, A Mohamed, T Onodera, H Kato, T Ohashi, R Goitsuka, H Tsujimoto, A Hasegawa, S Furusawa, K Yoshihara, J Ishikawa, K Hotta, K Suzuki, Y Hirota
Cytokine 1994
Interleukin 8 modulates interleukin-1β, interleukin-6 and tumor necrosis factor-α release from normal human mononuclear cells
CL Yu, KH Sun, SC Shei, CY Tsai, ST Tsai, JC Wang, TS Liao, WM Lin, HL Chen, HS Yu, SH Han
Immunopharmacology 1994
Quantitative PCR for Detection of Femtogram Quantities of Interleukin-8 mRNA Expression
R Izutani, H Ohyanagi, RP MacDermott
Microbiology and Immunology 1994
Interleukin-8 and Related Chemotactic Cytokines
M Baggiolini, B Moser, I Clark-Lewis
Chest 1994
In Vitro and In Vivo Activity of Human Interleukin-8 in Dogs
RD Zwahlen, D Spreng, M Wyder-Walther
Veterinary pathology 1994
Immunology of the Connective Tissue Diseases
GS Panayi
1994
Polarised interleukin 8 secretion by HT 29/19A cells
KM Lammers, J Jansen, PB Bijlsma, M Ceska, GN Tytgat, CL Laboisse, SJ van Deventer
Gut 1994
Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa
JE Crabtree, JI Wyatt, LK Trejdosiewicz, P Peichl, PH Nichols, N Ramsay, JN Primrose, IJ Lindley
Journal of clinical pathology 1994
Neutrophil Activation by Monomeric Interleukin-8
K Rajarathnam, BD Sykes, CM Kay, B Dewald, T Geiser, M Baggiolini, I Clark-Lewis
Science 1994
Molecular characterization of a novel rabbit interleukin-8 receptor isotype
GN Prado, KM Thomas, H Suzuki, GJ LaRosa, N Wilkinson, E Folco, J Navarro
The Journal of biological chemistry 1994
Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration
N Sheron, G Bird, J Koskinas, B Portmann, M Ceska, I Lindley, R William
Hepatology 1993
Gastric Interleukin-8 and IgA IL-8 Autoantibodies in Helicobacter pylori Infection
JE Crabtree, P Peichl, JI Wyatt, U Stachl, IJ Lindley
Scandinavian Journal of Immunology 1993
Glucocorticoids as cytokine inhibitors: role in neuroendocrine control and therapy of inflammatory diseases
G Fantuzzi, P Ghezzi
Mediators of Inflammation 1993
A factor released by monocytes in the presence of dexamethasone stimulates neutrophil locomotion
S Chettibi, AJ Lawrence, RD Stevenson
British Journal of Pharmacology 1993
Neutrophil chemotactic factors produced by malignant fibrous histiocytoma cell lines
M Yoshida, H Matsuzaki, H Hata, F Matsuno, M Takeya, H Okabe, K Takatsuki
British Journal of Cancer 1993
Interleukin-8 primes human neutrophils for enhanced superoxide anion production
A Wozniak, WH Betts, GA Murphy, M Rokicinski
Immunology 1993
Interferon-gamma inhibits interleukin-8 production by human polymorphonuclear leucocytes
MA Cassatella, I Guasparri, M Ceska, F Bazzoni, F Rossi
Immunology 1993
Interleukin-8 (IL-8) in synovial fluid of rheumatoid and nonrheumatoid joint effusions
CA Verburgh, MH Hart, LA Aarden, AJ Swaak
Clinical Rheumatology 1993
Interleukin-8 is a Cyclosporin A binding protein
H Bang, K Brune, C Nager, U Feige
Experientia 1993
Synergistic effect of interleukin-1β and tumor necrosis factor α on interleukin-8 gene expression in synovial fibroblasts. evidence that interleukin-8 is the major neutrophil-activating chemokine released in response to monokine activation
P Rathanaswami, M Hachicha, WL Wong, TJ Schall, SR Mccoll
Arthritis & Rheumatism 1993
Serum interleukin-8 in inflammatory bowel disease
SC Jones, SW Evans, AJ Lobo, M Ceska, AT Axon, JT Whicher
Journal of Gastroenterology and Hepatology 1993
The effect of interleukin-1 on cytokine gene expression in cultured human articular chondrocytes analyzed by messenger rna phenotyping
JM Seid, S Rahman, R Graveley, RA Bunning, R Nordmann, W Wishart, RG Russell
Arthritis & Rheumatism 1993
Radiation Pneumonitis: Bronchoalveolar Lavage Assessment and Modulation by a Recombinant Cytokine
RA Rosiello, WW Merrill, S Rockwell, D Carter, JA Cooper, S Care, EP Amento
American journal of respiratory and critical care medicine 1993
Host Defense Dysfunction in Trauma, Shock and Sepsis
E Faist, JL Meakins, FW Schildberg
1993
Progress in Immunology Vol. VIII
J Gergely, M Benczúr, A Erdei, A Falus, G Füst, G Medgyesi, G Petrányi, É Rajnavölgyi
1993
Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis
Y Raab, B Gerdin, S Ahlstedt, R Hallgren
Gut 1993
The Chemokines
IJ Lindley, J Westwick, S Kunkel
1993
Novel aspects of inflammation: interleukin-8 and related chemotactic cytokines
M Baggiolini
The Clinical Investigator 1993
Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis
M Lotz, T Moats, PM Villiger
Journal of Clinical Investigation 1992
Flare-up of experimental arthritis in mice with murine recombinant IL-1
AA Loo, OJ Arntz, WB Berg
Clinical & Experimental Immunology 1992
Induction of swelling, synovial hyperplasia and cartilage proteoglycan loss upon intra-articular injection of transforming growth factor β-2 in the rabbit
PR Elford, M Graeber, H Ohtsu, M Aeberhard, B Legendre, WL Wishart, AR MacKenzie
Cytokine 1992
Kinetics of cytokine secretion by mononuclear cells of the blood from rheumatoid arthritis patients are different from those of healthy controls
S Ruschen, W Stellberg, H Warnatz
Clinical & Experimental Immunology 1992
IL-8 as a circulating cytokine: induction by recombinant tumour necrosis factor-alpha
N Sheron, R Williams
Clinical & Experimental Immunology 1992
Dexamethasone prevents autoimmune nephritis and reduces renal expression of Ia but not costimulatory signals
AM Jevnikar, GG Singer, DC Brennan, HW Xu, VR Kelley
The American Journal of Pathology 1992
The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia
FQ Cunha, S Poole, BB Lorenzetti, SH Ferreira
British Journal of Pharmacology 1992
Interleukin-8, a chemotactic and inflammatory cytokine
M Baggiolini, I Clark-Lewis
FEBS Letters 1992
Interleukin-8 Stimulates Calcium Transients and Promotes Epidermal Cell Proliferation
A Tuschil, C Lam, A Haslberger, I Lindley
Journal of Investigative Dermatology 1992
Growth control of cultured microglia
S Ganter, H Northoff, D M�nnel, PJ Gebicke-H�rter
Journal of Neuroscience Research 1992
IP-10, a γ-interferon-inducible protein related to interleukin-8, lacks neutrophil activating properties
B Dewald, B Moser, L Barella, C Schumacher, M Baggiolini, I Clark-Lewis
Immunology Letters 1992
1 The immune system in health and disease
DJ Dudley
Baillière's Clinical Obstetrics and Gynaecology 1992
Interleukin 8
JM Schröder
Advances in Neuroimmunology 1992
The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia
FQ Cunha, S Poole, BB Lorenzetti, SH Ferreira
British Journal of Pharmacology 1992
Intervention with immunomodulatory agents: new pharmacological developments
EM Veys, H Mielants, G Verbruggen, FD Keyser
Baillière's Clinical Rheumatology 1992
Cytokine abnormalities in inflammatory arthritis
P Miossec
Baillière's Clinical Rheumatology 1992
Leukemia inhibitory factor (LIF): A growth factor with pleiotropic effects on bone biology
PV Vlasselaer
Progress in Growth Factor Research 1992
Regulation of Human Alveolar Macrophage- and Blood Monocyte-derived Interleukin-8 by Prostaglandin E 2 and Dexamethasone
TJ Standiford, SL Kunkel, MW Rolfe, HL Evanoff, RM Allen, RM Strieter
American journal of respiratory cell and molecular biology 1992
Neutrophilic Alveolitis in Idiopathic Pulmonary Fibrosis: The Role of Interleukin-8
JP Lynch, TJ Standiford, MW Rolfe, SL Kunkel, RM Strieter
American journal of respiratory and critical care medicine 1992
Interleukin-8 in inflammatory rheumatic diseases: synovial fluid levels, relation to rheumatoid factors, production by mononuclear cells, and effects of gold sodium thiomalate and methotrexate
M Seitz, B Dewald, M Ceska, N Gerber, M Baggiolini
Rheumatology International 1992
Mononuclear Phagocytes
R van Furth
1992
Immunohistochemical studies on NAP-1/IL-8 in contact eczema and atopic dermatitis
M Sticherling, E Bornscheuer, JM Schrder, E Christophers
Archives of Dermatological Research 1992
Induction of neutrophil infiltration by rat chemotactic cytokine (CINC) and its inhibition by dexamethasone in rats
N Hirasawa, M Watanabe, S Mue, K Watanabe, S Tsurufuji, K Ohuchi
Inflammation 1992
Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis
AE Koch, PJ Polverini, SL Kunkel, LA Harlow, LA DiPietro, VM Elner, SG Elner, RM Strieter
Science 1992
Interleukin-6 and Its Receptor: A Paradigm for Cytokines
T Kishimoto, S Akira, T Taga
Science 1992
Kinetics of cytokine secretion by mononuclear cells of the blood from rheumatoid arthritis patients are different from those of healthy controls.
Ruschen S, Stellberg W, Warnatz H
Clinical & Experimental Immunology 1992
Flare-up of experimental arthritis in mice with murine recombinant IL-1.
van de Loo AA, Arntz OJ, van den Berg WB
Clinical & Experimental Immunology 1992
Interleukins: Biological Properties and Therapeutic Potential
RE Elmslie, SW Dow, GK Ogilvie
Journal of Veterinary Internal Medicine 1991
International Review of Cytology
RA Miller
International Review of Cytology 1991
Molecular Aspects of Inflammation
H Sies, L Flohé, G Zimmer
1991
Scanning mutagenesis of interleukin-8 identifies a cluster of residues required for receptor binding
CA Hébert, RV Vitangcol, JB Baker
The Journal of biological chemistry 1991

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