Production of the neutrophil-activating peptide (NAP)-1/IL-8 by mononuclear phagocytes from patients with RA and from control subjects was studied under various conditions. Mononuclear cells from bone marrow (BMMC), PBMC, and synovial fluid (SFMC) were cultured for up to 48 h in the absence or presence of Escherichia coli LPS, different interleukins, interferon-gamma, zymosan, or immune complexes, and the neutrophil-stimulating activity released into the culture medium was determined. As shown by neutralization with an antiserum raised against human recombinant NAP-1/IL-8, over 90% of this activity could be attributed to NAP-1/IL-8. In unstimulated mononuclear cells from control individuals and BMMC from RA patients, the production of NAP-1/IL-8 was very low and was enhanced moderately by stimulation with LPS. By contrast, the spontaneous production of NAP-1/IL-8 was 3- to 10-fold higher in PBMC and even much higher in SFMC from RA patients. In all instances, the yield of NAP-1/IL-8 could be enhanced by stimulation in culture. In addition to LPS, rheumatoid factor-containing immune complexes, zymosan, and IL-1 were highly effective in inducing NAP-1/IL-8 production, while IL-3, GM-CSF, tumor necrosis factor (TNF), and IL-2 were somewhat less potent. An inhibitory effect was obtained with IFN-gamma, which significantly decreased the spontaneous NAP-1/IL-8 release from SFMC and the IL-1- and LPS-induced NAP-1/IL-8 from RA and control PBMC. Inhibition was also observed with glucocorticoids. The production of NAP-1/IL-8 was markedly reduced by dexamethasone in phagocytosis-stimulated PBMC, and almost totally inhibited in SFMC obtained from joints after intraarticular administration of betamethasone. By contrast, the cyclooxygenase inhibitor, indomethacin, tended to increase the NAP-1/IL-8 yield from PBMC in culture.
M Seitz, B Dewald, N Gerber, M Baggiolini
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Myeloid lineage cells evince distinct steady-state level of certain gene groups in dependence on hereditary angioedema severity
Ballonová L, Souček P, Slanina P, Réblová K, Zapletal O, Vlková M, Hakl R, Bíly V, Grombiříková H, Svobodová E, Kulíšková P, Štíchová J, Sobotková M, Zachová R, Hanzlíková J, Vachová M, Králíčková P, Krčmová I, Jeseňák M, Freiberger T |
Frontiers in Genetics | 2023 |
Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2
Casella BM, Farmer JP, Nesheva DN, Williams HE, Charlton SJ, Holliday ND, Laughton CA, Mistry SN |
Journal of Medicinal Chemistry | 2023 |
The expression levels of chemotaxis-related molecules CXC chemokine receptor 1, interleukin-8, and pro-platelet basic protein in gingival tissues.
Zeng WJ, Liu JR, Ouyang XY, Zhao QQ, Liu WY, Lv PY, Zhang SN, Zhong JS |
Journal of Dental Sciences | 2023 |
Psychosocial and behavioral factors affecting inflammation among pregnant African American women.
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2022 | |
Soybean Meal-Dependent Intestinal Inflammation Induces Different Patterns of Bone-Loss in Adult Zebrafish Scale
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Biomedicines | 2021 |
Increased Monocyte Inflammatory Responses to Oxidized LDL Are Associated with Insulin Resistance in HIV-Infected Individuals on Suppressive Antiretroviral Therapy
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Role of Nrf2 in rheumatoid arthritis
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Increased circulating interleukin-8 levels in systemic lupus erythematosus patients: a meta-analysis
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Inflammation - From Molecular and Cellular Mechanisms to the Clinic: From Molecular and Cellular Mechanisms to the Clinic
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Transcriptome analysis of the endangered Chinese giant salamander (Andrias davidianus): Immune modulation in response to Aeromonas hydrophila infection
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Veterinary Immunology and Immunopathology | 2016 |
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The CXCR1/2 Pathway: Involvement in Diabetes Pathophysiology and Potential Target for T1D Interventions
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Phytochemical Composition and Anti-Inflammatory Activity of Extracts from the Whole-Meal Flour of Italian Durum Wheat Cultivars
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The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases
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Piperine Suppresses the Expression of CXCL8 in Lipopolysaccharide-Activated SW480 and HT-29 Cells via Downregulating the Mitogen-Activated Protein Kinase Pathways
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Phage display and hybridoma generation of antibodies to human CXCR2 yields antibodies with distinct mechanisms and epitopes
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Pharmacogenetics of chronic pain and its treatment
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Current Protocols in Toxicology: In Vitro Chemotaxis Assays for Investigation of Toxicant-Induced Immunomodulation
KM Pietrosimone, S Bhandari, MG Lemieux, DA Knecht, MA Lynes |
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Efficacy of Radiation Countermeasures Depends on Radiation Quality
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Irsogladine maleate regulates barrier function and neutrophil accumulation in the gingival epithelium
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Journal of Oral Biosciences | 2012 |
H-2g, a glucose analog of blood group H antigen, mediates monocyte recruitment in vitro and in vivo via IL-8/CXCL8
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Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases
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Cytokines
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Annual Reports in Medicinal Chemistry
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Frontiers in bioscience (Elite edition) | 2009 |
Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: effect on the expression of chemokine and adhesion molecule
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Rheumatology International | 2009 |
Concomitant activation of P2Y2and P2Y6receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion
FB Yebdri, F Kukulski, A Tremblay, J Sévigny |
European Journal of Immunology | 2009 |
Synthetic studies towards bioactive frondosins: rapid framework access and diversity creation
G Mehta, NS Likhite |
Tetrahedron Letters | 2009 |
Concomitant activation of P2Y 2 and P2Y 6 receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion
FB Yebdri, F Kukulski, A Tremblay, J Sévigny |
European Journal of Immunology | 2009 |
Concomitant activation of P2Y 2 and P2Y 6 receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion
FB Yebdri, F Kukulski, A Tremblay, J Sévigny |
European Journal of Immunology | 2009 |
IL-8 as antibody therapeutic target in inflammatory diseases: reduction of clinical activity in palmoplantar pustulosis
L Skov, FJ Beurskens, CO Zachariae, S Reitamo, J Teeling, D Satijn, KM Knudsen, EP Boot, D Hudson, O Baadsgaard, PW Parren, JG van de Winkel |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Bestatin, an inhibitor for aminopeptidases, modulates the production of cytokines and chemokines by activated monocytes and macrophages
B Lkhagvaa, K Tani, K Sato, Y Toyoda, C Suzuka, S Sone |
Cytokine | 2008 |
A total synthesis of (±)-frondosins A and B
G Mehta, NS Likhite |
Tetrahedron Letters | 2008 |
Angiogenesis in Inflammation: Mechanisms and Clinical Correlates
MP Seed, DA Walsh |
2008 | |
A Concise Approach to the Polycyclic Scaffold of Frondosin D
KS Masters, BL Flynn |
The Journal of Organic Chemistry | 2008 |
Studies toward Frondosin A and Its Analogues. Formal Total Synthesis of (±)-Frondosin A
X Li, AE Keon, JA Sullivan, TV Ovaska |
Organic letters | 2008 |
Total syntheses of (±)-frondosin C and (±)-8-epi-frondosin C via a tandem anionic 5-exo dig cyclization–Claisen rearrangement sequence
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Tetrahedron | 2007 |
Total Synthesis of (±)-Frondosin B
X Li, TV Ovaska |
Organic letters | 2007 |
Current Concepts in Autoimmunity and Chronic Inflammation
A Radbruch, PE Lipsky |
2006 | |
IL-20: biological functions and clinical implications
CC Wei, YH Hsu, HH Li, YC Wang, MY Hsieh, WY Chen, CH Hsing, MS Chang |
Journal of Biomedical Science | 2006 |
Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis
YH Hsu, HH Li, MY Hsieh, MF Liu, KY Huang, LS Chin, PC Chen, HH Cheng, MS Chang |
Arthritis & Rheumatism | 2006 |
Progress toward the total synthesis of frondosin C
X Li, RE Kyne, TV Ovaska |
Organic letters | 2006 |
The effect of infliximab on chemokines in patients with rheumatoid arthritis
E Torikai, Y Kageyama, M Suzuki, T Ichikawa, A Nagano |
Clinical Rheumatology | 2006 |
Current Concepts in Autoimmunity and Chronic Inflammation
A Radbruch, PE Lipsky |
2006 | |
Blockade of TNF does not alter oxygen burst and phagocytosis of human neutrophils in patients with rheumatoid arthritis
P Hartmann, C Franzen, A Rubbert, J Rogowski, M Kailus, B Salzberger |
Immunobiology | 2005 |
Lornoxicam Inhibits Human Polymorphonuclear Cell Migration Induced by fMLP, Interleukin-8 and Substance P
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Chemokines in rheumatoid arthritis
P Loetscher |
Drug Discovery Today: Disease Mechanisms | 2005 |
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Arthritis & Rheumatism | 2004 |
The role of Interleukin-8 in interstitial pneumonia
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Respirology | 2003 |
Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma
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Arthritis & Rheumatism | 2003 |
Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases
E Bodolay, AE Koch, J Kim, G Szegedi, Z Szekanecz |
Journal of Cellular and Molecular Medicine | 2002 |
Human neutrophil lipocalin is a unique marker of neutrophil inflammation in ulcerative colitis and proctitis
M Carlson, Y Raab, L Sevéus, S Xu, R Hällgren, P Venge |
Gut | 2002 |
Relationship of changes in interleukin-8 levels and granulocyte elastase activity in gingival crevicular fluid to subgingival periodontopathogens followingnon-surgical periodontal therapy in subjects with chronic periodontitis
LJ Jin, WK Leung, EF Corbet, B Soder |
Journal of Clinical Periodontology | 2002 |
Feline interleukin-8 expression in peripheral blood mononuclear cells induced by egg white derivatives
MP Yang, KJ Lee, SM Yun, JH Kim, IK Ko, EB Jeung |
Veterinary Immunology and Immunopathology | 2002 |
Chemokines in synovial inflammation in rheumatoid arthritis: basic and clinical aspects
K Tani, T Shimizu, Y Motoki, S Sone |
Modern Rheumatology | 2002 |
Acute generalized exanthematous pustulosis, a clue to neutrophil-mediated inflammatory processes orchestrated by T cells:
M Britschgi, WJ Pichler |
Current Opinion in Allergy and Clinical Immunology | 2002 |
A Potent and Selective Nonpeptide Antagonist of CXCR2 Inhibits Acute and Chronic Models of Arthritis in the Rabbit
PL Podolin, BJ Bolognese, JJ Foley, DB Schmidt, PT Buckley, KL Widdowson, Q Jin, JR White, JM Lee, RB Goodman, TR Hagen, O Kajikawa, LA Marshall, DW Hay, HM Sarau |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Chemokines and angiogenesis
Z Szekanecz, AE Koch |
Current Opinion in Rheumatology | 2001 |
Surface expression of CC- and CXC-chemokine receptors on leucocyte subsets in inflammatory joint diseases
H Brühl, K Wagner, H Kellner, M Schattenkirchner, D Schlöndorff, M Mack |
Clinical & Experimental Immunology | 2001 |
Selective inhibition of interleukin-8-induced neutrophil chemotaxis by ketoprofen isomers 1
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Biochemical Pharmacology | 2001 |
POTENTIAL BIOLOGIC AGENTS FOR TREATING RHEUMATOID ARTHRITIS
LW Moreland |
Rheumatic Disease Clinics of North America | 2001 |
Coordinate Upregulation of Interleukin-8 and Growth-Related Gene Product-a is Present in the Colonic Mucosa of Inflammatory Bowel Disease
AI Yo |
Scandinavian Journal of Gastroenterology | 2001 |
Total Synthesis and Determination of the Absolute Configuration of Frondosin B
M Inoue, MW Carson, AJ Frontier, SJ Danishefsky |
Journal of the American Chemical Society | 2001 |
Hyperalgesia and edema responses induced by rat peripheral blood mononuclear cells incubated with carrageenin
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Inflammation | 2001 |
Interleukin-8 and Granulocyte Elastase in Gingival Crevicular Fluid in Relation to Periodontopathogens in Untreated Adult Periodontitis
L Jin, B Söder, EF Corbet |
Journal of Periodontology | 2000 |
Anti-CagA immunoglobulin G responses correlate with interleukin-8 induction in human gastric mucosal biopsy culture
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Clinical and diagnostic laboratory immunology | 2000 |
Neutrophils Regulate Their Own Apoptosis via Preservation of CXC Receptors
A Dunican, P Grutkoski, S Leuenroth, A Ayala, HH Simms |
Journal of Surgical Research | 2000 |
The Role of Natural Products in Drug Discovery
J Mulzer, R Bohlmann |
2000 | |
Pain and Neuroimmune Interactions
NE Saadé, AV Apkarian, SJ Jabbur |
2000 | |
Enhanced interleukin-8 production in THP-1 human monocytic cells by lipopolysaccharide from oral microorganisms and granulocyte-macrophage colony-stimulating factor
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Oral Microbiology and Immunology | 1999 |
Mucosal macrophage inflammatory protein-1α activity inHelicobacter pyloriinfection
K Kusugami, T Ando, A Imada, K Ina, M Ohsuga, T Shimizu, T Sakai, T Konagaya, H Kaneko |
Journal of Gastroenterology and Hepatology | 1999 |
Interleukin-8, Interleukin-10, Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 Expression Levels are Higher in Synovial Tissue from Patients with Rheumatoid Arthritis than in Osteoarthritis
Furuzawa-Carballeda, Alcocer-Varela |
Scandinavian Journal of Immunology | 1999 |
The Participation of IL-8 in the Synovial Lesions at an Early Stage of Rheumatoid Arthritis
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The Tohoku Journal of Experimental Medicine | 1999 |
Increased intraluminal release of eosinophil granule proteins EPO, ECP, EPX, and cytokines in ulcerative colitis and proctitis in segmental perfusion
M Carlson, Y Raab, C Peterson, R Hallgren, P Venge |
The American Journal of Gastroenterology | 1999 |
A Novel Polymorphism in the MCP-1 Gene Regulatory Region That Influences MCP-1 Expression
BH Rovin, L Lu, R Saxena |
Biochemical and Biophysical Research Communications | 1999 |
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CP Rader, T Sterner, F Jakob, N Schütze, J Eulert |
The Journal of Arthroplasty | 1999 |
Effect of pressure loading on interleukin-8 production in chondrocytes
T Kubo, Y Arai, K Takahashi, T Ishida, T Fujisawa, M Takigawa, J Imanishi, Y Hirasawa |
Pathophysiology | 1999 |
Oncostatin M: Development of a Pleiotropic Cytokine
JK Loy, TJ Davidson, KK Berry, JF Macmaster, B Danle, SK Durham |
Toxicologic pathology | 1999 |
Predominance of mononuclear cells expressing the chemokine receptor CCR5 in synovial effusions of patients with different forms of arthritis
M Mack, H Brhl, R Gruber, C Jaeger, J Cihak, V Eiter, J Plach, M Stangassinger, K Uhlig, M Schattenkirchner, D Schlndorff |
Arthritis & Rheumatism | 1999 |
Cytokines and Pain
LR Watkins, SF Maier |
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NB Pride |
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Journal of Gastroenterology and Hepatology | 1998 |
The central role of chemokines (chemotactic cytokines) in the immunopathogenesis of ulcerative colitis and Crohn's disease
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Biochemical and Biophysical Research Communications | 1998 |
Interleukin-16, produced by synovial fibroblasts, mediates chemoattraction for CD4+ T lymphocytes in rheumatoid arthritis
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European Journal of Immunology | 1998 |
Peripheral blood monocytes of rheumatoid arthritis patients do not express elevated TNF α, IL-1β, and IL-8 mRNA levels. A comparison of monocyte isolation procedures
RJ Rodenburg, FH Hoogen, LB de Putte, WJ Venrooij |
Journal of Immunological Methods | 1998 |
The Central Role of Chemokines (Chemotactic Cytokines) in the Immunopathogenesis of Ulcerative Colitis and Crohnʼs Disease:
RP MacDermott, IR Sanderson, HC Reinecker |
Inflammatory Bowel Diseases | 1998 |
Value of Early Blood Th-1 Cytokine Determination in Predicting Severity of Acute Pancreatitis
DH I. |
Scandinavian Journal of Gastroenterology | 1998 |
T Cells in Arthritis
P Miossec, GS Firestein, WB van den Berg |
1998 | |
Differential Normalization of Mucosal Interleukin-8 and Interleukin-6 Activity after Helicobacter pylori Eradication
JR McGhee, T Ando, K Kusugami, M Ohsuga, K Ina, M Shinoda, T Konagaya, T Sakai, A Imada, N Kasuga, T Nada, S Ichiyama, MJ Blaser |
Infection and immunity | 1998 |
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Szekanecz Z, Strieter RM, Kunkel SL, Koch AE |
Springer Seminars in Immunopathology | 1998 |
Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis?
GR Burmester, B Stuhlmüller, G Keyszer, RW Kinne |
Arthritis & Rheumatism | 1997 |
Oncostatin M stimulates monocyte chemoattractant protein-1- and interleukin-1-induced matrix metalloproteinase-1 production by human synovial fibroblasts in vitro
C Langdon, J Leith, CD Richards, F Smith |
Arthritis & Rheumatism | 1997 |
Elevated cytokine messenger RNA levels in the peripheral blood of patients with rheumatoid arthritis suggest different degrees of myeloid cell activation
H Schulze-Koops, LS Davis, AF Kavanaugh, PE Lipsky |
Arthritis & Rheumatism | 1997 |
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Immunology | 1997 |
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Journal of Experimental Medicine | 1997 |
Mucosal Chemokine Activity inHelicobacter pylori Infection
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Journal of Clinical Gastroenterology | 1997 |
Establishment of a Sandwich Enzyme Linked Immunosorbent Assay for Canine Interleukin-8
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Journal of Veterinary Medical Science | 1997 |
Cocaine Inhibits Human Endothelial Cell IL-8 Production: The Role of Transforming Growth Factor-β
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Cellular Immunology | 1997 |
Effects of pulse methylprednisolone on inflammatory mediators in peripheral blood, synovial fluid, and synovial membrane in rheumatoid arthritis
PP Youssef, DR Haynes, S Triantafillou, A Parker, JR Gamble, PJ Roberts-Thomson, MJ Ahern, MD Smith |
Arthritis & Rheumatism | 1997 |
Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone
SH Ferreira, FQ Cunha, BB Lorenzetti, MA Michelin, M Perretti, RJ Flower, S Poole |
British Journal of Pharmacology | 1997 |
Growth Factors and Cytokines in Health and Disease
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Growth Factors and Cytokines in Health and Disease | 1997 |
Frondosins, five new sesquiterpene hydroquinone derivatives with novel skeletons from the sponge Dysidea frondosa: Inhibitors of interleukin-8 receptors
AD Patil, AJ Freyer, L Killmer, P Offen, B Carte, AJ Jurewicz, RK Johnson |
Tetrahedron | 1997 |
Possible participation of macrophage inflammatory protein 2 in neutrophil infiltration in allergic inflammation in rats
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Biochimica et Biophysica Acta | 1997 |
Neutrophil trafficking into inflamed joints in patients with rheumatoid arthritis, and the effects of methylprednisolone
PP Youssef, J Cormack, CA Evill, DT Peter, PJ Roberts-Thomson, MJ Ahern, MD Smith |
Arthritis & Rheumatism | 1996 |
Alterations of the mucosal immune system in inflammatory bowel disease
RP MacDermoit |
Journal of Gastroenterology | 1996 |
Role of cytokines, acute-phase proteins, and chemokinesin the progression of rheumatoid arthritis
R Badolato, JJ Oppenheim |
Seminars in Arthritis and Rheumatism | 1996 |
ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
M Feldmann, FM Brennan, RN Maini |
Annual Review of Immunology | 1996 |
Opposite effects of interleukin-13 and interleukin-12 on the release of inflammatory cytokines, cytokine inhibitors and prostaglandin E from synovial fibroblasts and blood mononuclear cells
M Seitz, P Loetscher, B Dewald, H Towbin, M Baggiolini |
European Journal of Immunology | 1996 |
Interleukin-8 in Hodgkin's disease. Preferential expression by reactive cells and association with neutrophil density
HD Foss, H Herbst, S Gottstein, G Demel, I Araujó, H Stein |
The American Journal of Pathology | 1996 |
Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes
M Loetscher, B Gerber, P Loetscher, SA Jones, L Piali, I Clark-Lewis, M Baggiolini, B Moser |
Journal of Experimental Medicine | 1996 |
Design and evaluation of small peptides mapping the exposed surface of IL-8
SK Thompson, DF Veber, AJ Jurewicz, CE Peishoff, JM Lee, JR White |
International Journal of Peptide and Protein Research | 1996 |
Selective inhibition of interleukin-1β gene expression in activated RAW 264.7 macrophages by interferon-γ
CS Chujor, L Klein, C Lam |
European Journal of Immunology | 1996 |
The inhibitory effect of pentamidine on the production of chemotactic cytokines by in vitro stimulated human blood cells
J Wauwe, F Aerts, H Genechten, H Blockx, W Deleersnijder, H Walter |
Inflammation Research | 1996 |
Chemiluminescence Responses and Chemotaxis of Monocytes from Patients with Early Rheumatoid Arthritis
H Repo, L Paimela, M Leirisalo-Repo |
Scandinavian Journal of Rheumatology | 1996 |
Essentials of Mucosal Immunology
DK Podolsky |
Essentials of Mucosal Immunology | 1996 |
The Role of Interleukin-8 in Patients with Hematologic Diseases
H UENO, K HINO, K YAMADA, S YAMAMORI, S TOMOYASU, N TSURUOKA |
The Showa University Journal of Medical Sciences | 1996 |
Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis:
EJ Miller, AB Cohen, MA Matthay |
Critical Care Medicine | 1996 |
Interleukin 8: cells of origin in inflammatory bowel disease
MC Grimm, SK Elsbury, P Pavli, WF Doe |
Gut | 1996 |
Interleukin-1 alpha, interleukin-8 and interferon-alpha levels in gingival crevicular fluid
A Mathur, B Michalowicz, M Castillo, D Aeppll |
Journal of Periodontal Research | 1996 |
Roles of proinflammatory and anti-inflammatory cytokines in pathophysiology of bacterial meningitis and effect of adjunctive therapy
AM van Furth, JJ Roord, R van Furth |
Infection and immunity | 1996 |
The inhibitory effect of pentamidine on the production of chemotactic cytokines by in vitro stimulated human blood cells
JV Wauwe, F Aerts, HV Genechten, H Blockx, W Deleersnijder, H Walter |
Inflammation Research | 1996 |
Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis
T Kasama, RM Strieter, NW Lukacs, PM Lincoln, MD Burdick, SL Kunkel |
Journal of Clinical Investigation | 1995 |
Upregulated expression of IL-4 receptors and increased levels of IL-4 in rheumatoid arthritis patients
D Rivas, L Mozo, J Zamorano, A Gayo, JC Torre-Alonso, A Rodriguez, C Gutiérrez |
Journal of Autoimmunity | 1995 |
A review on the Strategies for the Development and Application of New Anti-arthritic Agents
AJ Lewis, AF Keft |
Immunopharmacology and Immunotoxicology | 1995 |
An Anti-Interleukin 8 Monoclonal Antibody That Interferes with the Binding of Interleukin 8 to Cellular Receptors and the Activation of Human Blood Neutrophils
A Kurdowska, E Miller, A Cohen |
Hybridoma | 1995 |
Production of TNF by Monocytes of Patients with Early Rheumatoid Arthritis is Increased
M Leirisalo-Repo, L Paimela, M Jäätteä, S Koskimies, H Repo |
Scandinavian Journal of Rheumatology | 1995 |
Interleukin-8 gene expression in the human colon epithelial cell line, HT-29, exposed to Entamoeba histolytica
JM Kim, HC Jung, K Im, YJ Cho, CY Kim |
The Korean Journal of Parasitology | 1995 |
Interleukin 8 and mast cell-generated tumor necrosis factor-? in neutrophil recruitment
Y Zhang, BF Ramos, B Jakschik, MP Baganoff, CL Deppeler, DM Meyer, DL Widomski, DJ Fretland, MA Bolanowski |
Inflammation | 1995 |
Indomethacin-induced gastric injury and leukocyte adherence in arthritic versus healthy rats
DM McCafferty, DN Granger, JL Wallace |
Gastroenterology | 1995 |
Neutrophil accumulation and activation by homologous IL-8 in rabbits. IL-8 induces destruction of cartilage and production of IL-1 and IL-1 receptor antagonist in vivo
RC Hoch, IU Schraufstätter, CG Cochrane |
Journal of immunology (Baltimore, Md. : 1950) | 1995 |
Aproximación inmunológica a las vasculitis sistémicas y pulmonares
JA Bermúdez |
Archivos de Bronconeumología | 1995 |
Chemokines, a Family of Chemotactic Cytokines
DT Groves, Y Jiang |
Critical Reviews in Oral Biology & Medicine | 1995 |
Identification and characterization of rhesus macaque interleukin-8
JC Minnerly, MP Baganoff, CL Deppeler, BT Keller, SR Rapp, DL Widomski, DJ Fretland, MA Bolanowski |
Inflammation | 1995 |
Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritis
AE Koch, SL Kunkel, LA Harlow, DD Mazarakis, GK Haines, MD Burdick, RM Pope, RM Strieter |
Journal of Clinical Investigation | 1994 |
Long-term impaired neutrophil migration in mice overexpressing human interleukin-8
WS Simonet, TM Hughes, HQ Nguyen, LD Trebasky, DM Danilenko, ES Medlock |
Journal of Clinical Investigation | 1994 |
Differential expression of two major cytokines produced by neutrophils, interleukin-8 and the interleukin-1 receptor antagonist, in neutrophils isolated from the synovial fluid and peripheral blood of patients with rheumatoid arthritis
AD Beaulieu, SR Mccoll |
Arthritis & Rheumatism | 1994 |
Monocyte chemoattractant protein 1 and interleukin 8 production by rheumatoid synoviocytes. Effects of anti-rheumatic drugs
P Loetscher, B Dewald, M Baggiolini, M Seitz |
Cytokine | 1994 |
Interaction between oncostatin M, interleukin 1 and prostaglandin E2 in induction of IL-6 expression in human fibroblasts
CD Richards, A Agro |
Cytokine | 1994 |
Cytokines and Acute Phase Proteins in Rheumatoid Arthritis
GW Duff |
Scandinavian Journal of Rheumatology | 1994 |
Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation
L Mazzucchelli, C Hauser, K Zgraggen, H Wagner, M Hess, JA Laissue, C Mueller |
The American Journal of Pathology | 1994 |
Localized expression of mRNA for phagocyte-specific chemotactic cytokines in human periodontal infections
MS Tonetti, MA Imboden, L Gerber, NP Lang, J Laissue, C Mueller |
Infection and immunity | 1994 |
Molecular cloning and expression of canine interleukin 8 cDNA
Y Matsumoto, A Mohamed, T Onodera, H Kato, T Ohashi, R Goitsuka, H Tsujimoto, A Hasegawa, S Furusawa, K Yoshihara, J Ishikawa, K Hotta, K Suzuki, Y Hirota |
Cytokine | 1994 |
Interleukin 8 modulates interleukin-1β, interleukin-6 and tumor necrosis factor-α release from normal human mononuclear cells
CL Yu, KH Sun, SC Shei, CY Tsai, ST Tsai, JC Wang, TS Liao, WM Lin, HL Chen, HS Yu, SH Han |
Immunopharmacology | 1994 |
Quantitative PCR for Detection of Femtogram Quantities of Interleukin-8 mRNA Expression
R Izutani, H Ohyanagi, RP MacDermott |
Microbiology and Immunology | 1994 |
Interleukin-8 and Related Chemotactic Cytokines
M Baggiolini, B Moser, I Clark-Lewis |
Chest | 1994 |
In Vitro and In Vivo Activity of Human Interleukin-8 in Dogs
RD Zwahlen, D Spreng, M Wyder-Walther |
Veterinary pathology | 1994 |
Immunology of the Connective Tissue Diseases
GS Panayi |
1994 | |
Polarised interleukin 8 secretion by HT 29/19A cells
KM Lammers, J Jansen, PB Bijlsma, M Ceska, GN Tytgat, CL Laboisse, SJ van Deventer |
Gut | 1994 |
Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa
JE Crabtree, JI Wyatt, LK Trejdosiewicz, P Peichl, PH Nichols, N Ramsay, JN Primrose, IJ Lindley |
Journal of clinical pathology | 1994 |
Neutrophil Activation by Monomeric Interleukin-8
K Rajarathnam, BD Sykes, CM Kay, B Dewald, T Geiser, M Baggiolini, I Clark-Lewis |
Science | 1994 |
Molecular characterization of a novel rabbit interleukin-8 receptor isotype
GN Prado, KM Thomas, H Suzuki, GJ LaRosa, N Wilkinson, E Folco, J Navarro |
The Journal of biological chemistry | 1994 |
Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration
N Sheron, G Bird, J Koskinas, B Portmann, M Ceska, I Lindley, R William |
Hepatology | 1993 |
Gastric Interleukin-8 and IgA IL-8 Autoantibodies in Helicobacter pylori Infection
JE Crabtree, P Peichl, JI Wyatt, U Stachl, IJ Lindley |
Scandinavian Journal of Immunology | 1993 |
Glucocorticoids as cytokine inhibitors: role in neuroendocrine control and therapy of inflammatory diseases
G Fantuzzi, P Ghezzi |
Mediators of Inflammation | 1993 |
A factor released by monocytes in the presence of dexamethasone stimulates neutrophil locomotion
S Chettibi, AJ Lawrence, RD Stevenson |
British Journal of Pharmacology | 1993 |
Neutrophil chemotactic factors produced by malignant fibrous histiocytoma cell lines
M Yoshida, H Matsuzaki, H Hata, F Matsuno, M Takeya, H Okabe, K Takatsuki |
British Journal of Cancer | 1993 |
Interleukin-8 primes human neutrophils for enhanced superoxide anion production
A Wozniak, WH Betts, GA Murphy, M Rokicinski |
Immunology | 1993 |
Interferon-gamma inhibits interleukin-8 production by human polymorphonuclear leucocytes
MA Cassatella, I Guasparri, M Ceska, F Bazzoni, F Rossi |
Immunology | 1993 |
Interleukin-8 (IL-8) in synovial fluid of rheumatoid and nonrheumatoid joint effusions
CA Verburgh, MH Hart, LA Aarden, AJ Swaak |
Clinical Rheumatology | 1993 |
Interleukin-8 is a Cyclosporin A binding protein
H Bang, K Brune, C Nager, U Feige |
Experientia | 1993 |
Synergistic effect of interleukin-1β and tumor necrosis factor α on interleukin-8 gene expression in synovial fibroblasts. evidence that interleukin-8 is the major neutrophil-activating chemokine released in response to monokine activation
P Rathanaswami, M Hachicha, WL Wong, TJ Schall, SR Mccoll |
Arthritis & Rheumatism | 1993 |
Serum interleukin-8 in inflammatory bowel disease
SC Jones, SW Evans, AJ Lobo, M Ceska, AT Axon, JT Whicher |
Journal of Gastroenterology and Hepatology | 1993 |
The effect of interleukin-1 on cytokine gene expression in cultured human articular chondrocytes analyzed by messenger rna phenotyping
JM Seid, S Rahman, R Graveley, RA Bunning, R Nordmann, W Wishart, RG Russell |
Arthritis & Rheumatism | 1993 |
Radiation Pneumonitis: Bronchoalveolar Lavage Assessment and Modulation by a Recombinant Cytokine
RA Rosiello, WW Merrill, S Rockwell, D Carter, JA Cooper, S Care, EP Amento |
American journal of respiratory and critical care medicine | 1993 |
Host Defense Dysfunction in Trauma, Shock and Sepsis
E Faist, JL Meakins, FW Schildberg |
1993 | |
Progress in Immunology Vol. VIII
J Gergely, M Benczúr, A Erdei, A Falus, G Füst, G Medgyesi, G Petrányi, É Rajnavölgyi |
1993 | |
Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis
Y Raab, B Gerdin, S Ahlstedt, R Hallgren |
Gut | 1993 |
The Chemokines
IJ Lindley, J Westwick, S Kunkel |
1993 | |
Novel aspects of inflammation: interleukin-8 and related chemotactic cytokines
M Baggiolini |
The Clinical Investigator | 1993 |
Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis
M Lotz, T Moats, PM Villiger |
Journal of Clinical Investigation | 1992 |
Flare-up of experimental arthritis in mice with murine recombinant IL-1
AA Loo, OJ Arntz, WB Berg |
Clinical & Experimental Immunology | 1992 |
Induction of swelling, synovial hyperplasia and cartilage proteoglycan loss upon intra-articular injection of transforming growth factor β-2 in the rabbit
PR Elford, M Graeber, H Ohtsu, M Aeberhard, B Legendre, WL Wishart, AR MacKenzie |
Cytokine | 1992 |
Kinetics of cytokine secretion by mononuclear cells of the blood from rheumatoid arthritis patients are different from those of healthy controls
S Ruschen, W Stellberg, H Warnatz |
Clinical & Experimental Immunology | 1992 |
IL-8 as a circulating cytokine: induction by recombinant tumour necrosis factor-alpha
N Sheron, R Williams |
Clinical & Experimental Immunology | 1992 |
Dexamethasone prevents autoimmune nephritis and reduces renal expression of Ia but not costimulatory signals
AM Jevnikar, GG Singer, DC Brennan, HW Xu, VR Kelley |
The American Journal of Pathology | 1992 |
The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia
FQ Cunha, S Poole, BB Lorenzetti, SH Ferreira |
British Journal of Pharmacology | 1992 |
Interleukin-8, a chemotactic and inflammatory cytokine
M Baggiolini, I Clark-Lewis |
FEBS Letters | 1992 |
Interleukin-8 Stimulates Calcium Transients and Promotes Epidermal Cell Proliferation
A Tuschil, C Lam, A Haslberger, I Lindley |
Journal of Investigative Dermatology | 1992 |
Growth control of cultured microglia
S Ganter, H Northoff, D M�nnel, PJ Gebicke-H�rter |
Journal of Neuroscience Research | 1992 |
IP-10, a γ-interferon-inducible protein related to interleukin-8, lacks neutrophil activating properties
B Dewald, B Moser, L Barella, C Schumacher, M Baggiolini, I Clark-Lewis |
Immunology Letters | 1992 |
1 The immune system in health and disease
DJ Dudley |
Baillière's Clinical Obstetrics and Gynaecology | 1992 |
Interleukin 8
JM Schröder |
Advances in Neuroimmunology | 1992 |
The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia
FQ Cunha, S Poole, BB Lorenzetti, SH Ferreira |
British Journal of Pharmacology | 1992 |
Intervention with immunomodulatory agents: new pharmacological developments
EM Veys, H Mielants, G Verbruggen, FD Keyser |
Baillière's Clinical Rheumatology | 1992 |
Cytokine abnormalities in inflammatory arthritis
P Miossec |
Baillière's Clinical Rheumatology | 1992 |
Leukemia inhibitory factor (LIF): A growth factor with pleiotropic effects on bone biology
PV Vlasselaer |
Progress in Growth Factor Research | 1992 |
Regulation of Human Alveolar Macrophage- and Blood Monocyte-derived Interleukin-8 by Prostaglandin E 2 and Dexamethasone
TJ Standiford, SL Kunkel, MW Rolfe, HL Evanoff, RM Allen, RM Strieter |
American journal of respiratory cell and molecular biology | 1992 |
Neutrophilic Alveolitis in Idiopathic Pulmonary Fibrosis: The Role of Interleukin-8
JP Lynch, TJ Standiford, MW Rolfe, SL Kunkel, RM Strieter |
American journal of respiratory and critical care medicine | 1992 |
Interleukin-8 in inflammatory rheumatic diseases: synovial fluid levels, relation to rheumatoid factors, production by mononuclear cells, and effects of gold sodium thiomalate and methotrexate
M Seitz, B Dewald, M Ceska, N Gerber, M Baggiolini |
Rheumatology International | 1992 |
Mononuclear Phagocytes
R van Furth |
1992 | |
Immunohistochemical studies on NAP-1/IL-8 in contact eczema and atopic dermatitis
M Sticherling, E Bornscheuer, JM Schrder, E Christophers |
Archives of Dermatological Research | 1992 |
Induction of neutrophil infiltration by rat chemotactic cytokine (CINC) and its inhibition by dexamethasone in rats
N Hirasawa, M Watanabe, S Mue, K Watanabe, S Tsurufuji, K Ohuchi |
Inflammation | 1992 |
Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis
AE Koch, PJ Polverini, SL Kunkel, LA Harlow, LA DiPietro, VM Elner, SG Elner, RM Strieter |
Science | 1992 |
Interleukin-6 and Its Receptor: A Paradigm for Cytokines
T Kishimoto, S Akira, T Taga |
Science | 1992 |
Kinetics of cytokine secretion by mononuclear cells of the blood from rheumatoid arthritis patients are different from those of healthy controls.
Ruschen S, Stellberg W, Warnatz H |
Clinical & Experimental Immunology | 1992 |
Flare-up of experimental arthritis in mice with murine recombinant IL-1.
van de Loo AA, Arntz OJ, van den Berg WB |
Clinical & Experimental Immunology | 1992 |
Interleukins: Biological Properties and Therapeutic Potential
RE Elmslie, SW Dow, GK Ogilvie |
Journal of Veterinary Internal Medicine | 1991 |
International Review of Cytology
RA Miller |
International Review of Cytology | 1991 |
Molecular Aspects of Inflammation
H Sies, L Flohé, G Zimmer |
1991 | |
Scanning mutagenesis of interleukin-8 identifies a cluster of residues required for receptor binding
CA Hébert, RV Vitangcol, JB Baker |
The Journal of biological chemistry | 1991 |