125I-Serum amyloid P component (SAP), injected intravenously into 10 normal subjects, remained predominantly intravascular with mean (SD) T1/2 (half time) in plasma of 24.5 (5.9) h. The fractional catabolic rate of 68 (19)% of the plasma pool per day was more rapid than other reported human plasma proteins. All radioactivity was excreted in the urine by 14 d. In 16 patients with monoclonal gammopathy or chronic inflammatory diseases, but without amyloidosis, 125I-SAP metabolism was normal. However, among 45 patients with biopsy-proven systemic amyloidosis (25, amyloid A type; 20, amyloid L type), 125I-SAP was cleared from the plasma more rapidly, accumulated in the amyloid deposits, and persisted there. The T1/2 in amyloid, measured directly with 131I-SAP, was 24 d. Repeat studies after 6-18 mo were notably consistent in normals but changed significantly in amyloid patients, generally correlating with clinical signs of disease progression. Measurements of 125I-SAP turnover may thus be of value for diagnosis and monitoring of amyloidosis. Analysis of SAP metabolism in amyloidosis suggests that plasma SAP is in dynamic equilibrium with a very large amyloid pool, and in two autopsies the total mass of SAP in the amyloid deposits was 2,100 and 21,000 mg, respectively.
P N Hawkins, R Wootton, M B Pepys
Title and authors | Publication | Year |
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A New Era for PET/CT: Applications in Non-Tumorous Renal Pathologies
Moghrabi S, Abdlkadir AS, Al-Hajaj N, Gnanasegaran G, Kumar R, Syed G, Bozkurt MF, Shukri S, Obeidat S, Khalaf A, Shahait M, Al-Nabhani K, Al-Ibraheem A |
Journal of Clinical Medicine | 2024 |
Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection
G Patra, B Saha, S Mukhopadhyay |
Scientific Reports | 2021 |
Cardiac amyloidosis
A Giorgetti, D Genovesi, E Milan, W Acampa, R Giubbini, A Cuocolo, P Marzullo |
Clinical and Translational Imaging | 2019 |
The Development of Serum Amyloid P as a Possible Therapeutic
D Pilling, RH Gomer |
Frontiers in immunology | 2018 |
Pentraxins CRP-I and CRP-II are post-translationally deiminated and differ in tissue specificity in cod (Gadus morhua L.) ontogeny
B Magnadóttir, P Hayes, B Gísladóttir, BÞ Bragason, M Hristova, AP Nicholas, S Guðmundsdóttir, S Lange |
Developmental and comparative immunology | 2018 |
The Pentraxins 1975–2018: Serendipity, Diagnostics and Drugs
MB Pepys |
Frontiers in immunology | 2018 |
Evaluation of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single Intravenous Dose of Miridesap in Healthy Japanese Subjects
H Ino, Y Doi, L Liefaard, L Cookson, C Chen, H Itoh, H Igarashi, A Nakano |
Clinical Pharmacology in Drug Development | 2018 |
Target Mediated Drug Disposition Model of CPHPC in Patients with Systemic Amyloidosis: Target Mediated Drug Disposition Model of CPHPC
T Sahota, A Berges, S Barton, L Cookson, S Zamuner, D Richards |
The Journal of Pathology | 2015 |
Amyloid persistence in decellularized liver: biochemical and histopathological characterization
G Mazza, JP Simons, R Al-Shawi, S Ellmerich, L Urbani, S Giorgetti, GW Taylor, JA Gilbertson, AR Hall, W Al-Akkad, D Dhar, PN Hawkins, PD Coppi, M Pinzani, V Bellotti, PP Mangione |
Amyloid | 2015 |
Nuclear imaging of amyloidosis
W Cytawa, J Teodorczyk, P Lass |
Polish Journal of Radiology | 2014 |
Imaging in systemic amyloidosis
S Sachchithanantham, AD Wechalekar |
British Medical Bulletin | 2013 |
Pathogenetic mechanisms of amyloid A amyloidosis
JP Simons, R Al-Shawi, S Ellmerich, I Speck, S Aslam, WL Hutchinson, PP Mangione, P Disterer, JA Gilbertson, T Hunt, DJ Millar, S Minogue, K Bodin, MB Pepys, PN Hawkins |
Proceedings of the National Academy of Sciences | 2013 |
Diagnosis of amyloidosis and differentiation from chronic, idiopathic enterocolitis in rhesus (Macaca mulatta) and pig-tailed (M. nemestrina) macaques
KA Rice, ES Chen, KA Pate, EK Hutchinson, RJ Adams |
Comparative medicine | 2013 |
Re-evaluating the potentials and limitations of (99m)Tc-aprotinin scintigraphy for amyloid imaging
R Minamimoto, K Kubota, K Ishii, M Morooka, M Okasaki, Y Miyata, K Nakajima, T Sato, T Igari, R Hirai, O Okazaki |
American journal of nuclear medicine and molecular imaging | 2013 |
Re-evaluating the potentials and limitations of 99mTc-aprotinin scintigraphy for amyloid imaging
R Minamimoto, K Kubota, K Ishii, M Morooka, M Okasaki, Y Miyata, K Nakajima, T Sato, T Igari, R Hirai, O Okazaki |
American journal of nuclear medicine and molecular imaging | 2013 |
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use
MB Pepys, JR Gallimore, J Lloyd, Z Li, D Graham, GW Taylor, S Ellmerich, PP Mangione, GA Tennent, WL Hutchinson, DJ Millar, G Bennett, J More, D Evans, Y Mistry, S Poole, PN Hawkins |
Journal of Immunological Methods | 2012 |
AL Amyloid Imaging and Therapy with a Monoclonal Antibody to a Cryptic Epitope on Amyloid Fibrils
JS Wall, SJ Kennel, A Williams, T Richey, A Stuckey, Y Huang, S Macy, R Donnell, R Barbour, P Seubert, D Schenk, P Westermark |
PloS one | 2012 |
Macrophage Differentiation and Polarization via Phosphatidylinositol 3-Kinase/Akt–ERK Signaling Pathway Conferred by Serum Amyloid P Component
W Zhang, W Xu, S Xiong |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
Avances en el tratamiento de la amiloidosis
F Martínez-Valle, M Gironella-Mesa, R Solans-Laqué |
Medicina Clínica | 2011 |
Sustained pharmacological depletion of serum amyloid P component in patients with systemic amyloidosis
JD Gillmore, GA Tennent, WL Hutchinson, JR Gallimore, HJ Lachmann, HJ Goodman, M Offer, DJ Millar, A Petrie, PN Hawkins, MB Pepys |
British Journal of Haematology | 2010 |
Serologic evaluation of clinical and subclinical secondary hepatic amyloidosis in rhesus macaques (Macaca mulatta)
JG MacGuire, KL Christe, JA Yee, AL Kalman-Bowlus, NW Lerche |
Comparative medicine | 2009 |
Target Pattern Recognition in Innate Immunity
U Kishore |
2009 | |
Pattern recognition by pentraxins.
Agrawal A, Singh PP, Bottazzi B, Garlanda C, Mantovani A |
Advances in experimental medicine and biology | 2009 |
Novartis Foundation Symposia
EJ Campbell |
Ciba Foundation Symposium 44 - Research and Medical Practice: Their Interaction | 2008 |
Normal circulating serum amyloid P component concentration in systemic sclerosis
GA Tennent, M Dziadzio, E Triantafillidou, P Davies, JR Gallimore, CP Denton, MB Pepys |
Arthritis & Rheumatism | 2007 |
Diagnostic Performance of 123I-Labeled Serum Amyloid P Component Scintigraphy in Patients with Amyloidosis
BP Hazenberg, MH van Rijswijk, DA Piers, MN Hooge, E Vellenga, EB Haagsma, PN Hawkins, PL Jager |
The American Journal of Medicine | 2006 |
Glycosaminoglycans inhibit neurodegenerative effects of serum amyloid P component in vitro
Z Urbányi, E Forrai, M Sárvári, I Likó, J Illés, T Pázmány |
Neurochemistry International | 2005 |
Quantitative high-resolution microradiographic imaging of amyloid deposits in a novel murine model of AA amyloidosis
JS Wall, SJ Kennel, MJ Paulus, S Gleason, J Gregor, J Baba, M Schell, T Richey, B O'nuallain, R Donnell, PN Hawkins, DT Weiss, A Solomon |
Amyloid | 2005 |
Serum amyloid P component in mink, a non-glycosylated protein with affinity for phosphorylethanolamine and phosphorylcholine
LA Omtvedt, TN Wien, T Myran, K Sletten, G Husby |
Amyloid | 2004 |
Serum amyloid P component induces neuronal apoptosis and β-amyloid immunoreactivity
Z Urbányi, L László, TB Tomasi, E Tóth, É Mekes, M Sass, T Pázmány |
Brain Research | 2003 |
Monoclonal Gammopathies and the Kidney
G Touchard, P Aucouturier, O Hermine, P Ronco |
2003 | |
Serum amyloid P component scintigraphy for diagnosis and monitoring amyloidosis
PN Hawkins |
Current Opinion in Nephrology and Hypertension | 2002 |
Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis
MB Pepys, J Herbert, WL Hutchinson, GA Tennent, HJ Lachmann, JR Gallimore, LB Lovat, T Bartfai, A Alanine, C Hertel, T Hoffmann, R Jakob-Roetne, RD Norcross, JA Kemp, K Yamamura, M Suzuki, GW Taylor, S Murray, D Thompson, A Purvis, S Kolstoe, SP Wood, PN Hawkins |
Nature | 2002 |
The Systemic and Local Acute Phase Response Following Acute Brain Injury
DC Wilcockson, SJ Campbell, DC Anthony, VH Perry |
Journal of Cerebral Blood Flow & Metabolism | 2002 |
Diagnostic tools for amyloidosis
E Hachulla, G Grateau |
Joint Bone Spine | 2002 |
Moyens paracliniques du diagnostic des amyloses
É Hachulla, G Grateau |
Revue du Rhumatisme | 2002 |
Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein
JD Gillmore, LB Lovat, MR Persey, MB Pepys, PN Hawkins |
The Lancet | 2001 |
Pathogenesis, diagnosis and treatment of systemic amyloidosis
CM Dobson, RJ Ellis, AR Fersht, MB Pepys |
Philosophical Transactions of The Royal Society B Biological Sciences | 2001 |
Mécanismes de l'amylose et protéines impliquées
H Lebrazi, E Hachulla, R Saile |
La Revue de Médecine Interne | 2000 |
Renal transplantation for amyloid end-stage renal failure-insights from serial serum amyloid P component scintigraphy
JD Gillmore, S Madhoo, MB Pepys, PN Hawkins |
Nuclear Medicine Communications | 2000 |
Stratégie diagnostique des amyloses
G Grateau, H Lebrazi, S Valleix, E Hachulla, M Delpech, R Saïle |
La Revue de Médecine Interne | 2000 |
Human Serum Amyloid P Component is a Single Uncomplexed Pentamer in Whole Serum
WL Hutchinson, E Hohenester, MB Pepys |
Molecular Medicine | 2000 |
C-reactive protein and complement are important mediators of tissue damage in acute myocardial infarction
M Griselli, J Herbert, WL Hutchinson, KM Taylor, M Sohail, T Krausz, MB Pepys |
Journal of Experimental Medicine | 1999 |
C-Reactive Protein and Complement Are Important Mediators of Tissue Damage in Acute Myocardial Infarction
M Griselli, J Herbert, WL Hutchinson, KM Taylor, M Sohail, T Krausz, MB Pepys |
Journal of Experimental Medicine | 1999 |
The liver in systemic amyloidosis: insights from 123I serum amyloid P component scintigraphy in 484 patients
LB Lovat, MR Persey, S Madhoo, MB Pepys, PN Hawkins |
Gut | 1998 |
Protein aggregation: folding aggregates, inclusion bodies and amyloid
AL Fink |
Folding and Design | 1998 |
Amyloid P component. A critical review
MB Pepys, DR Booth, WL Hutchinson, JR Gallimore, IM Collins, E Hohenester |
Amyloid | 1997 |
Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene
M Botto, PN Hawkins, MC Bickerstaff, J Herbert, AE Bygrave, A Mcbride, WL Hutchinson, GA Tennent, MJ Walportz, MB Pepys |
Nature Medicine | 1997 |
Echocardiographic assessment of cardiac involvement in systemic AL amyloidosis in relation to whole body amyloid load measured by serum amyloid P component (SAP) clearance
GJ Clesham, DM Vigushin, PN Hawkins, MB Pepys, CM Oakley, P Nihoyannopoulos |
The American Journal of Cardiology | 1997 |
Long term effect of renal transplantation on dialysis-related amyloid deposits and symptomatology
SY Tan, A Irish, CG Winearls, EA Brown, PE Gower, EJ Clutterbuck, S Madhoo, JP Lavender, MB Pepys, PN Hawkins |
Kidney International | 1996 |
Diagnosis and treatment of primary amyloidosis
E Pascali |
Critical Reviews in Oncology/Hematology | 1995 |
Imaging amyloidosis with radiolabelled SAP
PN Hawkins, MB Pepys |
European Journal of Nuclear Medicine | 1995 |
Treatment of amyloidosis
SY Tan, MB Pepys, PN Hawkins |
American Journal of Kidney Diseases | 1995 |
Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis
GA Tennent, LB Lovat, MB Pepys |
Proceedings of the National Academy of Sciences | 1995 |
A Novel Variant of Transthyretin, 59 Thr→Lys , Associated With Autosomal Dominant Cardiac Amyloidosis in an Italian Family
DR Booth, SY Tan, PN Hawkins, MB Pepys, A Frustaci |
Circulation | 1995 |
The pentraxins, C-reactive protein and serum amyloid P component, are cleared and catabolized by hepatocytes in vivo
WL Hutchinson, GE Noble, PN Hawkins, MB Pepys |
Journal of Clinical Investigation | 1994 |
Binding of pentraxins to different nuclear structures: C-reactive protein binds to small nuclear ribonucleoprotein particles, serum amyloid P component binds to chromatin and nucleoli
MB Pepys, SE Booth, GA Tennent, PJ Butler, DG Williams |
Clinical & Experimental Immunology | 1994 |
Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure
MB Pepys, TW Rademacher, S Amatayakul-Chantler, P Williams, GE Noble, WL Hutchinson, PN Hawkins, SR Nelson, JR Gallimore, J Herbert |
Proceedings of the National Academy of Sciences | 1994 |
Proteoglycans, glycosaminoglycans and amyloid deposition
JH Magnus, T Stenstad, G Husby |
Baillière's Clinical Rheumatology | 1994 |
Diagnosis and monitoring of amyloidosis
PN Hawkins |
Baillière's Clinical Rheumatology | 1994 |
Binding of pentraxins to different nuclear structures: C-reactive protein binds to small nuclear ribonucleoprotein particles, serum amyloid P component binds to chromatin and nucleoli.
Pepys MB, Booth SE, Tennent GA, Butler PJ, Williams DG |
Clinical & Experimental Immunology | 1994 |
Labeling of cerebral amyloid in vivo with a monoclonal antibody.
Walker LC, Price DL, Voytko ML, Schenk DB |
Journal of Neuropathology and Experimental Neurology | 1994 |
Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis
G Holmgren, L Steen, O Suhr, BG Ericzon, CG Groth, O Andersen, BG Wallin, A Seymour, S Richardson, PN Hawkins, MB Pepys |
The Lancet | 1993 |
On the association between amyloid fibrils and glycosaminoglycans; possible interactive role of Ca2+ and amyloid P-component
T Stenstad, JH Magnus, K Syse, G Husby |
Clinical & Experimental Immunology | 1993 |
Studies of the structure and binding properties of hamster female protein
GA Tennent, ML Baltz, GD Osborn, PJ Butler, GE Noble, PN Hawkins, MB Pepys |
Immunology | 1993 |
Severe dominant dystrophic epidermolysis bullosa complicated by systemic amyloidosis
MG Dunnill, RB Mallett, PN Hawkins, PJ Vallance, RA Marsden |
British Journal of Dermatology | 1993 |
Serum amyloid p component scintigraphy and turnover studies for diagnosis and quantitative monitoring of aa amyloidosis in juvenile rheumatoid arthritis
PN Hawkins, S Richardson, DM Vigushin, J David, CR Kelsey, RE Gray, MA Hall, P Woo, JP Lavender, MB Pepys |
Arthritis & Rheumatism | 1993 |
Hamster female protein binding to chromatin, histones and DNA
L Saunero-Nava, JE Coe, C Mold, TW du Clos |
Molecular Immunology | 1992 |
Induction in mice of human light-chain-associated amyloidosis
A Solomon, DT Weiss, MB Pepys |
The American Journal of Pathology | 1992 |
Amyloid P component and the diagnosis of amyloidosis
MB Pepys |
Journal of Internal Medicine | 1992 |
Studies in vivo and in vitro of serum amyloid P component in normals and in a patient with AA amyloidosis
PN Hawkins, GA Tennent, P Woo, MB Pepys |
Clinical & Experimental Immunology | 1991 |
Serum amyloid P component in chronic renal failure and dialysis
SR Nelson, GA Tennent, D Sethi, PE Gower, FW Ballardie, S Amatayakul-Chantler, MB Pepys |
Clinica Chimica Acta | 1991 |
Imaging of haemodialysis-associated amyloidosis with 123I-serum amyloid P component
SR Nelson, PN Hawkins, S Richardson, MB Pepys, JP Lavender, D Sethi, PE Gower, CW Pugh, CG Winearls, DO Oliver |
The Lancet | 1991 |
Amyloidosis
PN Hawkins |
Blood Reviews | 1988 |