As a model system to explore the functional consequences of structural variants of human Fc gamma receptors (Fc gamma R), we have investigated Fc gamma R-mediated phagocytosis in relation to the NA1-NA2 polymorphism of Fc gamma RIII (CD16) on neutrophils (Fc gamma RIIIPMN). The neutrophil-specific NA antigen system is a biallelic polymorphism with codominant expression demonstrating a gene dose effect with the anti-NA1 MAb CLB-gran 11 in a large donor population. To explore the impact of this allelic variation of Fc gamma RIIIPMN on phagocytosis, we used two Fc gamma RIII-dependent probes, IgG-sensitized erythrocytes (EA) and concanavalin. A-treated erythrocytes (E-ConA). Comparison of Fc gamma R-mediated phagocytosis by PMN from NA1 subjects and from NA2 subjects showed lower levels of phagocytosis of both probes by the NA2 individuals. The difference was most pronounced with lightly opsonized EA: at the lowest level of sensitization the phagocytic index was 72% lower for NA2 donors, whereas at the highest level of sensitization it was 21% lower (P less than 0.003). Blockade of Fc gamma RII with MAb IV.3 Fab amplified by threefold the difference between NA1 and NA2 donors. NA1 and NA2 individuals had identical phagocytic capacities for the non-Fc gamma RIII probes, serum-treated and heat-treated zymosan. These individuals did not show differential quantitative cell surface expression of Fc gamma RIIIPMN measured by a panel of anti-CD16 MAb (3G8, CLB FcR-gran 1, VEP13, BW209/2) and by Scatchard analysis of 125I-IgG dimer binding. The difference in Fc gamma R-mediated phagocytosis was not explicable on the basis of differential collaboration of Fc gamma RIIIPMN alleles with Fc gamma RII, since (a) the difference in phagocytic capacity between NA1 and NA2 individuals was readily apparent with the E-ConA probe (which is independent of Fc gamma RII) and (b) the difference in phagocytosis of EA was magnified by Fc gamma RII blockade. The demonstration that allelic polymorphisms in Fc gamma R can have significant consequences for physiological functions implies that within the structural complexity of human Fc gamma Rs, including both allelic forms and cell type-specific isoforms, there will be differences in quantitative, and perhaps qualitative, function with potential importance for disease processes.
J E Salmon, J C Edberg, R P Kimberly
Title and authors | Publication | Year |
---|---|---|
Fc gamma receptor polymorphisms in antibody therapy: implications for bioassay development to enhance product quality
Twomey JD, George S, Zhang B |
Antibody Therapeutics | 2025 |
Natural killer cell-based cancer immunotherapy: from basics to clinical trials.
Shi Y, Hao D, Qian H, Tao Z |
Experimental hematology & oncology | 2024 |
CD56briCD38+ as a novel neutrophil-specific marker in chronic myeloid leukemia
Huang P, Zhang C, Zhang A, Mao J, Liu G, Hu C, Zhu H |
Heliyon | 2024 |
Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease
Frampton S, Smith R, Ferson L, Gibson J, Hollox EJ, Cragg MS, Strefford JC |
Immunological Reviews | 2024 |
Anti-Cancer Effects of Oxygen-Atom-Modified Derivatives of Wasabi Components on Human Leukemia Cells.
Lin JF, Chi CW, Huang YC, Tsai TH, Chen YJ |
International journal of molecular sciences | 2023 |
FCGR3A gene duplication, FcγRIIb-232TT and FcγRIIIb-HNA1a associate with an increased risk of vertical acquisition of HIV-1.
Ebonwu J, Lassaunière R, Paximadis M, Strehlau R, Gray GE, Kuhn L, Tiemessen CT |
PloS one | 2022 |
FcγR Genetic Variation and HIV-1 Vaccine Efficacy: Context And Considerations
R Lassaunière, CT Tiemessen |
Frontiers in immunology | 2021 |
Flow Cytometry of Hematological Malignancies
C Ortolani |
Flow Cytometry of Hematological Malignancies | 2021 |
FCGR Genetic Variation in Two Populations From Ecuador Highlands—Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene
M Moraru, A Perez-Portilla, KA Sanz, A Blazquez-Moreno, A Arnaiz-Villena, HT Reyburn, C Vilches |
Frontiers in immunology | 2021 |
Functional Fc Gamma Receptor Gene Polymorphisms and Long-Term Kidney Allograft Survival
M Wahrmann, B Döhler, ML Arnold, S Scherer, KA Mayer, S Haindl, H Haslacher, GA Böhmig, C Süsal |
Frontiers in immunology | 2021 |
Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB
AK Fall, C Dechavanne, A Sabbagh, E Guitard, J Milet, A Garcia, JM Dugoujon, D Courtin, F Migot-Nabias |
Frontiers in immunology | 2020 |
Site-Specific Glycosylation Mapping of Fc Gamma Receptor IIIb from Neutrophils of Individual Healthy Donors
I Wojcik, T Sénard, EL de Graaf, GM Janssen, AH de Ru, Y Mohammed, PA van Veelen, G Vidarsson, M Wuhrer, D Falck |
Analytical Chemistry | 2020 |
IgG and Fcγ Receptors in Intestinal Immunity and Inflammation
T Castro-Dopico, MR Clatworthy |
Frontiers in immunology | 2019 |
Genetic Variation in Low-To-Medium-Affinity Fcγ Receptors: Functional Consequences, Disease Associations, and Opportunities for Personalized Medicine
SQ Nagelkerke, DE Schmidt, M de Haas, TW Kuijpers |
Frontiers in immunology | 2019 |
Expression, Role, and Regulation of Neutrophil Fcγ Receptors
Y Wang, F Jönsson |
Frontiers in immunology | 2019 |
Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis
DE Geraghty, CW Thorball, J Fellay, R Thomas |
Frontiers in immunology | 2019 |
FcγRIIIb Restricts Antibody-Dependent Destruction of Cancer Cells by Human Neutrophils
LW Treffers, M van Houdt, CW Bruggeman, MH Heineke, , J van der Heijden, SQ Nagelkerke, PJ Verkuijlen, J Geissler, S Lissenberg-Thunnissen, T Valerius, M Peipp, K Franke, R van Bruggen, TW Kuijpers, M van Egmond, G Vidarsson, HL Matlung, TK van den Berg |
Frontiers in immunology | 2019 |
Molecular and Functional Characterization of Fcγ Receptor IIIb-Ligand Interaction: Implications for Neutrophil-Mediated Immune Mechanisms in Malaria
P Simtong, AV Romphruk, A Traum, M Burg-Roderfeld, G Bein, K Jakubowski, A Dominik, M Theisen, IH Kana, UJ Sachs, S Santoso, JH Adams |
Infection and immunity | 2018 |
Characterization of Endogenous Human FcγRIII by Mass Spectrometry Reveals Site, Allele and Sequence Specific Glycosylation*
N Washburn, R Meccariello, J Duffner, K Getchell, K Holte, T Prod'homme, K Srinivasan, R Prenovitz, J Lansing, I Capila, G Kaundinya, AM Manning, CJ Bosques |
Molecular & cellular proteomics : MCP | 2018 |
Fcγ Receptor Heterogeneity in Leukocyte Functional Responses
C Rosales |
Frontiers in immunology | 2017 |
Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya
EO Munde, WA Okeyo, E Raballah, SB Anyona, T Were, JM Ongecha, DJ Perkins, C Ouma |
BMC Infectious Diseases | 2017 |
Lupus
WA Khan |
Lupus | 2017 |
Assessment of HNA alloimmunisation risk in Northeastern Thais, Burmese and Karen: HNAs in Northeastern Thais, Burmese and Karen
P Simtong, C Puapairoj, C Leelayuwat, S Santoso, AV Romphruk |
Transfusion Medicine | 2017 |
Improvement of monoclonal antibody-immobilized granulocyte antigen assay for the detection of anti-HNA-1 alloantibodies: MODIFIED MAIGA ASSAY
P Simtong, AV Romphruk, C Hofmann, A Reil, UJ Sachs, S Santoso |
Transfusion | 2017 |
Perinatal HIV-1 transmission: Fc gamma receptor variability associates with maternal infectiousness and infant susceptibility
R Lassaunière, A Musekiwa, GE Gray, L Kuhn, CT Tiemessen |
Retrovirology | 2016 |
No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population
ME Dourado, LC Ferreira, FP Freire-Neto, SM Jeronimo |
Journal of Neuroimmunology | 2016 |
Genetic Variants That Are Associated with Neuropsychiatric Systemic Lupus Erythematosus
RC Ho, H Ong, C Thiaghu, Y Lu, CS Ho, MW Zhang |
The Journal of rheumatology | 2016 |
Genetics of Lupus Nephritis: Clinical Implications
ME Munroe, JA James |
Seminars in Nephrology | 2015 |
Allelic and copy-number variations of FcγRs affect granulocyte function and susceptibility for autoimmune blistering diseases
A Recke, G Vidarsson, RJ Ludwig, M Freitag, S Möller, R Vonthein, J Schellenberger, O Haase, S Görg, A Nebel, F Flachsbart, S Schreiber, W Lieb, R Gläser, S Benoit, M Sárdy, R Eming, M Hertl, D Zillikens, IR König, E Schmidt, S Ibrahim |
Journal of Autoimmunity | 2015 |
Association of a coding polymorphism in Fc gamma receptor 2A and graft survival in re-transplant candidates
ML Arnold, BG Fuernrohr, KM Weiß, U Harre, MS Wiesener, BM Spriewald |
Human Immunology | 2015 |
Fcγ receptors: genetic variation, function, and disease
CE Hargreaves, MJ Rose-Zerilli, LR Machado, C Iriyama, EJ Hollox, MS Cragg, JC Strefford |
Immunological Reviews | 2015 |
Variability at the FCGR locus: characterization in Black South Africans and evidence for ethnic variation in and out of Africa
R Lassaunière, CT Tiemessen |
Genes and Immunity | 2015 |
Immunomodulation by IVIg and the Role of Fc-Gamma Receptors: Classic Mechanisms of Action after all?
SQ Nagelkerke, TW Kuijpers |
Frontiers in immunology | 2015 |
Genetics of ANCA-associated Vasculitides
MF Ugarte-Gil, LR Espinoza |
Current Rheumatology Reports | 2014 |
Human gene copy number variation and infectious disease
EJ Hollox, BP Hoh |
Human Genetics | 2014 |
Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies
C Gillis, A Gouel-Chéron, F Jönsson, P Bruhns |
Frontiers in immunology | 2014 |
Current Topics in Microbiology and Immunology
X Li, AW Gibson, RP Kimberly |
Current topics in microbiology and immunology | 2014 |
Pediatric Critical Care Medicine
JL Wynn, JA Hazelzet, TP Shanley, HR Wong, DS Wheeler |
Pediatric Critical Care Medicine | 2014 |
Haplotypes of FcγRIIa and FcγRIIIb Polymorphic Variants Influence IgG-Mediated Responses in Neutrophils
J van der Heijden, S Nagelkerke, X Zhao, J Geissler, T Rispens, TK van den Berg, TW Kuijpers |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
Fc RIII (CD16) equips immature 6-sulfo LacNAc-expressing dendritic cells (slanDCs) with a unique capacity to handle IgG-complexed antigens
T Dobel, A Kunze, J Babatz, K Trankner, A Ludwig, M Schmitz, A Enk, K Schakel |
Blood | 2013 |
Dubois' Lupus Erythematosus and Related Syndromes
JC Crispín, GC Tsokos |
Dubois' Lupus Erythematosus and Related Syndromes | 2013 |
Genetic susceptibility to meningococcal infection
AP Dale, RC Read |
Expert Review of Anti-infective Therapy | 2013 |
The applied basic research of systemic lupus erythematosus based on the biological omics
W Sui, X Hou, W Che, M Yang, Y Dai |
Genes and Immunity | 2013 |
No association of primary Sjögren’s syndrome with Fcγ receptor gene variants
K Haldorsen, S Appel, SL Hellard, O Bruland, JG Brun, R Omdal, G Kristjansdottir, E Theander, CP Fernandes, M Kvarnström, P Eriksson, L Rönnblom, MW Herlenius, G Nordmark, R Jonsson, AI Bolstad |
Genes and Immunity | 2013 |
Impact of Allele Copy Number of Polymorphisms in FCGR3A and FCGR3B Genes on Susceptibility to Ulcerative Colitis:
K Asano, T Matsumoto, J Umeno, A Hirano, M Esaki, N Hosono, T Matsui, Y Kiyohara, Y Nakamura, M Kubo, T Kitazono |
Inflammatory Bowel Diseases | 2013 |
Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab
J Golay, FD Roit, L Bologna, C Ferrara, JH Leusen, A Rambaldi, C Klein, M Introna |
Blood | 2013 |
Association of FcγRIIIa-158V/F with systemic lupus erythematosus in a Chinese population
M Dai, Z Zhou, X Wang, X Qian, X Huang |
International Journal of Rheumatic Diseases | 2013 |
Fc receptors: Cell activators of antibody functions
C Rosales, E Uribe-Querol |
Advances in bioscience and biotechnology (Print) | 2013 |
Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis
JI Robinson, IM Carr, DL Cooper, LH Rashid, SG Martin, P Emery, JD Isaacs, A Barton, AG Wilson, JH Barrett, AW Morgan |
Human Mutation | 2012 |
Rapid enzyme-linked immunosorbent assay for the detection of antibodies against human neutrophil antigens -1a, -1b, and -1c
S Werth, B Bayat, Y Tjahjono, J Eskandar, H Berghöfer, G Bein, UJ Sachs, S Santoso |
Transfusion | 2012 |
Fc γ receptor IIIB (FcγRIIIB) polymorphisms are associated with clinical malaria in Ghanaian children
B Adu, D Dodoo, S Adukpo, PL Hedley, FK Arthur, TA Gerds, SO Larsen, M Christiansen, M Theisen |
PloS one | 2012 |
The host genetic diversity in malaria infection
VR de Mendonça, MS Goncalves, M Barral-Netto |
Journal of Tropical Medicine | 2012 |
Protective Effects of FCGR2A Polymorphism in Invasive Pneumococcal Diseases
A Bouglé, A Max, N Mongardon, D Grimaldi, F Pène, C Rousseau, JD Chiche, JP Bedos, E Vicaut, JP Mira |
Chest | 2012 |
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné |
Advances in Immunology Volume 110 | 2011 |
Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children
C Ouma, GC Davenport, S Garcia, P Kempaiah, A Chaudhary, T Were, SB Anyona, E Raballah, SN Konah, JB Hittner, JM Vulule, JM Ong’echa, DJ Perkins |
Human Genetics | 2011 |
Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study
E Sánchez, ME Comeau, BI Freedman, JA Kelly, KM Kaufman, CD Langefeld, EE Brown, GS Alarcón, RP Kimberly, JC Edberg, R Ramsey-Goldman, M Petri, JD Reveille, LM Vilá, JT Merrill, BP Tsao, DL Kamen, GS Gilkeson, JA James, TJ Vyse, PM Gaffney, CO Jacob, TB Niewold, BC Richardson, JB Harley, ME Alarcón-Riquelme, AH Sawalha |
Arthritis & Rheumatism | 2011 |
Distribution function approach to the study of the kinetics of IgM antibody binding to FcγRIIIb (CD16b) receptors on neutrophils by flow cytometry
DY Orlova, VI Borisov, VS Kozhevnikov, VP Maltsev, AV Chernyshev |
Journal of Theoretical Biology | 2011 |
The fundamentals of neutrophil antigen and antibody investigations : Neutrophil antigen and antibody investigations
YL Fung, RM Minchinton |
ISBT Science Series | 2011 |
IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis
JM Kelley, PA Monach, C Ji, Y Zhou, J Wu, S Tanaka, AD Mahr, S Johnson, C McAlear, D Cuthbertson, S Carette, JC Davis, PF Dellaripa, GS Hoffman, N Khalidi, CA Langford, P Seo, EW st Clair, U Specks, JH Stone, RF Spiera, SR Ytterberg, PA Merkel, JC Edberg, RP Kimberly |
Proceedings of the National Academy of Sciences | 2011 |
Humoral Pathogenesis
T Ernandez, TN Mayadas∗ |
Systemic Lupus Erythematosus | 2011 |
Constitutive Genes and Lupus
BP Tsao, Y Deng |
Systemic Lupus Erythematosus | 2011 |
Fcγ Receptor IIIb (CD16b) Polymorphisms are Associated with Susceptibility to Idiopathic Pulmonary Fibrosis
S Bournazos, I Bournazou, JT Murchison, WA Wallace, P McFarlane, N Hirani, AJ Simpson, I Dransfield, SP Hart |
Lung | 2010 |
Genetic susceptibility to systemic lupus erythematosus in the genomic era
Y Deng, BP Tsao |
Nature Reviews Rheumatology | 2010 |
Lack of association of FcγRIIIb polymorphisms with systemic lupus erythematosus: a meta-analysis
H Yuan, JD Ni, HF Pan, LH Li, JB Feng, DQ Ye |
Rheumatology International | 2010 |
The association of Fcγreceptor IIIb genetic polymorphism and susceptibility to periodontitis in Taiwanese individuals
YP Ho, YH Yang, KY Ho, YM Wu, CC Tsai |
Journal of Clinical Periodontology | 2010 |
Fcγreceptor polymorphisms and their association with periodontal disease: a meta-analysis
NL Dimou, GK Nikolopoulos, SJ Hamodrakas, PG Bagos |
Journal of Clinical Periodontology | 2010 |
Association of FcgR2a, but not FcgR3a, with inflammatory bowel diseases across three Caucasian populations
RK Weersma, JB Crusius, RL Roberts, BP Koeleman, R Palomino-Morales, S Wolfkamp, JE Hollis-Moffatt, EA Festen, S Meisneris, R Heijmans, CL Noble, RB Gearry, ML Barclay, M Gómez-Garcia, MA Lopez-Nevot, A Nieto, L Rodrigo, TR Radstake, AA van Bodegraven, C Wijmenga, TR Merriman, PC Stokkers, AS Peña, J Martín, BZ Alizadeh |
Inflammatory Bowel Diseases | 2010 |
FcγRIIB, FcγRIIIB, and systemic lupus erythematosus
HA Niederer, MR Clatworthy, LC Willcocks, KG Smith |
Annals of the New York Academy of Sciences | 2010 |
Evidence for both copy number and allelic (NA1/NA2) risk at the FCGR3B locus in systemic lupus erythematosus
DL Morris, AL Roberts, AS Witherden, R Tarzi, P Barros, JC Whittaker, TH Cook, TJ Aitman, TJ Vyse |
European Journal of Human Genetics | 2010 |
Anti-polymorphonuclear neutrophil antibodies in patients with leukopenia or neutropenia
NE Riera, MR Saltó, V Galán, K Canalejo, M Khoury, M Aixalá, GL Kantor, M Vermeulen, R Bengió, MM de Bracco |
International Journal of Laboratory Hematology | 2010 |
The single nucleotide polymorphisms gene but not the copy number variation of Fcgr3B is associated with lupus nephritis in Chinese people
H Yang, Q Zhou, DJ Chen, H Jiang, YY Mao, JH Chen |
Lupus | 2010 |
Functional Variants of Fc Gamma Receptor (FCGR2A) and FCGR3A Are Not Associated with Susceptibility to Systemic Sclerosis in a Large European Study (EUSTAR)
BZ Alizadeh, J Broen, B Rueda, R Hesselstrand, D Wuttge, C Simeon, N Ortego-Centeno, MA Gonzalez-Gay, A Pros, A Herrick, J Worthington, C Denton, C Fonseca, G Riemekasten, MC Vonk, FR van den HOOGEN, S Guiducci, M Matucci-Cerinic, R Scorza, L Beretta, P Airó, M Coenen, JA Martin, BP Koeleman, TR Radstake |
The Journal of rheumatology | 2010 |
Transfusionsmedizin und Immunhämatologie
V Kiefel, C Mueller-Eckhardt |
2010 | |
Fcγ receptors: structure, function and role as genetic risk factors in SLE
X Li, TS Ptacek, EE Brown, JC Edberg |
Genes and Immunity | 2009 |
Functional and clinical consequences of Fc receptor polymorphic and copy number variants
S Bournazos, JM Woof, SP Hart, I Dransfield |
Clinical & Experimental Immunology | 2009 |
Linkage and association study of Fc��R polymorphisms in celiac disease
I Sareneva, LL Koskinen, IR Korponay-Szabo, K Kaukinen, K Kurppa, F Ziberna, S Vatta, T Not, A Ventura, R ��d��ny, Z Pocsai, G Sz��les, M M��ki, P Saavalainen, E Einarsdottir |
Tissue Antigens | 2009 |
An integrated approach for measuring copy number variation at the FCGR3 (CD16) locus
EJ Hollox, JC Detering, T Dehnugara |
Human Mutation | 2009 |
Phagocyte-Pathogen Interactions: Macrophages and the Host Response to Infection
DG Russell, S Gordon |
2009 | |
Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses
P Bruhns, B Iannascoli, P England, DA Mancardi, N Fernandez, S Jorieux, M Daëron |
Blood | 2008 |
Genetic Polymorphisms in Critical Care and Illness
Dahmer MK, Quasney MW |
2008 | |
Fundamental and Clinical Cardiology Series
PD Stein |
Cardiovascular Disease in the Elderly | 2008 |
Human neutrophil alloantigens
J Bux |
Vox Sanguinis | 2008 |
Neutrophil role in in vivo anti-lymphoma activity of rituximab: FCGR3B-NA1/NA2 polymorphism does not influence response and survival after rituximab treatment
G Cartron, M Ohresser, G Salles, P Solal-Celigny, P Colombat, H Watier |
Annals of Oncology | 2008 |
Science and Practice of Pediatric Critical Care Medicine
DS Wheeler, HR Wong, TP Shanley |
2008 | |
Infectious Diseases in the Pediatric Intensive Care Unit
S Nadel |
2008 | |
Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen species
AM Fairhurst, PK Wallace, AS Jawad, NJ Goulding |
Arthritis Research & Therapy | 2007 |
Pharmacogenetics of anti-TNF treatment in patients with rheumatoid arthritis
MJ Coenen, EJ Toonen, H Scheffer, TR Radstake, P Barrera, B Franke |
Pharmacogenomics | 2007 |
Blood Banking and Transfusion Medicine
JM Fisk, PT Pisciotto, EL Snyder, PL Perrotta |
Blood Banking and Transfusion Medicine | 2007 |
Fc receptor genes and the systemic lupus erythematosus diathesis
EE Brown, JC Edberg, RP Kimberly |
Autoimmunity | 2007 |
Gene Polymorphisms and the Prevalence of Key Periodontal Pathogens
L Nibali, DR Ready, M Parkar, PM Brett, M Wilson, MS Tonetti, GS Griffiths |
Journal of dental research | 2007 |
NADPH oxidase (CYBA) and FcγR polymorphisms as risk factors for aggressive periodontitis: A case–control association study
L Nibali, M Parkar, P Brett, J Knight, MS Tonetti, GS Griffiths |
Journal of Clinical Periodontology | 2006 |
Systemic Lupus Erythematosus
M Petri |
JCR: Journal of Clinical Rheumatology | 2006 |
Genetics of susceptibility and severity in systemic lupus erythematosus
JA Croker, RP Kimberly |
Current Opinion in Rheumatology | 2005 |
Genetic polymorphisms in sepsis
MK Dahmer, A Randolph, S Vitali, MW Quasney |
Pediatric Critical Care Medicine | 2005 |
Analysis of Fcgamma receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B
AW Morgan, JH Barrett, B Griffiths, D Subramanian, JI Robinson, VH Keyte, M Ali, EA Jones, RW Old, F Ponchel, AW Boylston, RD Situnayake, AF Markham, P Emery, JD Isaacs |
Arthritis Research & Therapy | 2005 |
Polymorphism of the Fcgamma receptor IIA and malaria morbidity
EM Braga, KK Scopel, NT Komatsu, M Silva-Nunes, MU Ferreira |
Journal of molecular and genetic medicine : an international journal of biomedical research | 2005 |
Genetic polymorphisms in sepsis:
MK Dahmer, A Randolph, S Vitali, MW Quasney |
Pediatric Critical Care Medicine | 2005 |
The association between FcgRIIIB polymorphisms and systemic lupus erythematosus in Korea
CH Hong, JS Lee, HS Lee, SC Bae, DH Yoo |
Lupus | 2005 |
Granulocyte gene polymorphisms and mutations: effects on immune response and neutrophil proliferation
D Stroncek |
Vox Sanguinis | 2004 |
Both risk alleles for FcγRIIA and FcγRIIIA are susceptibility factors for SLE: a unifying hypothesis
V Magnusson, B Johanneson, G Lima, J Odeberg, D Alarcón-Segovia, ME Alarcón-Riquelme |
Genes and Immunity | 2004 |
Transfusionsmedizin
C Mueller-Eckhardt, V Kiefel |
Transfusionsmedizin - Immunhämatologie Hämotherapie Immungenetik Zelltherapie | 2004 |
Immune-Mediated Hemolytic Anemia
WF Rosse, P Hillmen, AD Schreiber |
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program | 2004 |
Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais
U Siriboonrit, N Tsuchiya, M Sirikong, C Kyogoku, S Bejrachandra, P Suthipinittharm, K Luangtrakool, D Srinak, R Thongpradit, K Fujiwara, D Chandanayingyong, K Tokunaga |
Tissue Antigens | 2003 |
FcγRIIIb Allele-Sensitive Release of α-Defensins: Anti-Neutrophil Cytoplasmic Antibody-Induced Release of Chemotaxins
S Tanaka, JC Edberg, W Chatham, G Fassina, RP Kimberly |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
FcgRIIA, FcgammaRIIIA and FcgammaRIIIB polymorphisms in Spanish patients with systemic lupus erythematosus
MF Gonzalez-Escribano, F Aguilar, J Sanchez-Roman, A Nunez-Roldan |
European Journal of Immunogenetics | 2002 |
Fcγ Receptor Genes as Risk Markers for Localized Aggressive Periodontitis in African-Americans
Y Fu, JM Korostoff, DH Fine, ME Wilson |
Journal of Periodontology | 2002 |
Supernatants of stored polymorphonuclear neutrophils exhibit growth-promoting activity in several cell lines: perforin expression in polymorphonuclear neutrophils and its role in down-regulation of growth-promoting activity
M Nishimura, S Mitsunaga, T Juji |
Vox Sanguinis | 2002 |
Pathogenic effects of anti-Fc gamma receptor IIIb (CD16) on polymorphonuclear neutrophils in non-organ-specific autoimmune diseases
P Youinou, V Durand, Y Renaudineau, YL Pennec, A Saraux, C Jamin |
Autoimmunity Reviews | 2002 |
Fcγ receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria
K Omi, J Ohashi, J Patarapotikul, H Hananantachai, I Naka, S Looareesuwan, K Tokunaga |
Parasitology International | 2002 |
Expression of FcγRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions
F Davoine, S Lavigne, J Chakir, C Ferland, MÈ Boulay, M Laviolette |
Journal of Allergy and Clinical Immunology | 2002 |
Associations between Fc gamma receptor IIA polymorphisms and the risk and prognosis of meningococcal disease
P Domingo, E Muñiz-Diaz, MA Baraldès, M Arilla, N Barquet, R Pericas, C Juárez, P Madoz, G Vázquez |
The American Journal of Medicine | 2002 |
Redox regulation of Fcgamma receptor-mediated phagocytosis: implications for host defense and tissue injury
L Pricop, JE Salmon |
Antioxidants & Redox Signaling | 2002 |
Diversity and duplicity: human FCgamma receptors in host defense and autoimmunity
RP Kimberly, J Wu, AW Gibson, K Su, H Qin, X Li, JC Edberg |
Immunologic Research | 2002 |
Patterns of low-affinity immunoglobulin receptor polymorphisms in stroke and homozygous sickle cell disease
JG VI, D Tang, CB Foster, GR Serjeant, GP Rodgers, SJ Chanock |
American Journal of Hematology | 2002 |
Fc? receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: Contribution ofFCGR2B to genetic susceptibility
C Kyogoku, HM Dijstelbloem, N Tsuchiya, Y Hatta, H Kato, A Yamaguchi, T Fukazawa, MD Jansen, H Hashimoto, JG van de Winkel, CG Kallenberg, K Tokunaga |
Arthritis & Rheumatism | 2002 |
The genetics of systemic lupus erythematosus: putting the pieces together
JA Kelly, KL Moser, JB Harley |
Genes and Immunity | 2002 |
Roles of Fc receptors in autoimmunity
T Takai |
Nature Reviews Immunology | 2002 |
The expression of NA antigens in people withunusual Fcgamma receptor III genotypes
K Matsuo, JL Procter, S Chanock, DF Stroncek |
Transfusion | 2001 |
Polymorphisms in inflammatory cytokines and Fcgamma receptors in childhood chronic immune thrombocytopenic purpura: a pilot study
CB Foster, S Zhu, HC Erichsen, T Lehrnbecher, ES Hart, E Choi, S Stein, MW Smith, SM Steinberg, P Imbach, T Kuhne, SJ Chanock |
British Journal of Haematology | 2001 |
Fcgamma receptors in autoimmune diseases
G Fossati, RC Bucknall, SW Edwards |
European Journal of Clinical Investigation | 2001 |
Soluble Fcγ receptor IIIb alters the function of polymorphonuclear neutrophils but extends their survival
V Durand, JO Pers, Y Renaudineau, P Youinou, C Jamin |
European Journal of Immunology | 2001 |
Transcription Factor NF??B Expression and Postsurgical Organ Dysfunction
S Foulds, C Galustian, AO Mansfield, M Schachter |
Annals of Surgery | 2001 |
Transcription factor NF kappa B expression and postsurgical organ dysfunction
S Foulds, C Galustian, AO Mansfield, M Schachter |
Annals of Surgery | 2001 |
FcγRIII b and FcγRIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy
S Taniuchi, M Masuda, A Yamamoto, M Hasui, S Tsuji, Y Komiyama, H Takahashi, Y Kobayashi |
Human Immunology | 2001 |
Frozen-stored granulocytes can be used for an immunofluorescence test to detect granulocyte antibodies
M Nishimura, S Mitsunaga, T Juji |
Transfusion | 2001 |
Inflammatory Diseases of Blood Vessels
G Hansson |
Inflammatory Diseases of Blood Vessels: A Dialogue Between the Artery and the Immune System | 2001 |
FcγRIIa/IIIa polymorphism and its association with clinical manifestations in Korean lupus patients
HR Yun, HK Koh, SS Kim, WT Chung, DW Kim, KP Hong, GG Song, HK Chang, JY Choe, SC Bae, JE Salmon, DH Yoo, TY Kim, SY Kim |
Lupus | 2001 |
FcγRIIa polymorphism in Japanese patients with systemic lupus erythematosus
H Sato, M Iwano, Y Akai, T Nishino, T Fujimoto, H Shiiki, K Dohi |
Lupus | 2001 |
Increased Frequency of FcγRIIIb-NA1 Allele in Periodontitis-resistant Subjects in an Elderly Japanese Population
N Sugita, T Kobayashi, Y Ando, A Yoshihara, K Yamamoto, JG de Winked, H Miyazaki, H Yoshie |
Journal of dental research | 2001 |
Bispecific Monoclonal Antibodies Mediate Binding of Dengue Virus to Erythrocytes in a Monkey Model of Passive Viremia
CS Hahn, OG French, P Foley, EN Martin, RP Taylor |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
C-reactive protein binding to FcγRIIa on human monocytes and neutrophils is allele-specific
MP Stein, JC Edberg, RP Kimberly, EK Mangan, D Bharadwaj, C Mold, TW du Clos |
Journal of Clinical Investigation | 2000 |
Variations in genes encoding neutrophil antigens NA1 and NA2
K Matsuo, J Procter, D Stroncek |
Transfusion | 2000 |
Association Between Fc RIIa-R131 Allotype and Bacteremic Pneumococcal Pneumonia
AM Yee, HM Phan, R Zuniga, JE Salmon, DM Musher |
Clinical Infectious Diseases | 2000 |
Lupus Susceptibility Genes on Human Chromosome 1
BR Tsao |
International Reviews of Immunology | 2000 |
Neutrophil FcgammaRIIIb allelic polymorphism in anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis
WY Tse, S Abadeh, R Jefferis, CO Savage, D Adu |
Clinical & Experimental Immunology | 2000 |
Effect of Allotype on Activation of Neutrophils by FcγRIIIB Cross-Linking
P Scott-Zaki, D Purkall, S Ruddy |
Cellular Immunology | 2000 |
IgG allotypes and subclasses in Norwegian patients with multiple sclerosis
G Raknes, JA Filho, JP Pandey, KM Myhr, E Ulvestad, H Nyland, CA Vedeler |
Journal of the Neurological Sciences | 2000 |
Nosocomial Pneumonia
UL Specks |
Nosocomial Pneumonia | 2000 |
Evaluation of Human FcγRIIA (CD32) and FcγRIIIB (CD16) Polymorphisms in Caucasians and African-Americans Using Salivary DNA
RC van Schie, ME Wilson |
Clinical and diagnostic laboratory immunology | 2000 |
Relevance of Fc gamma RIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients
N Sugita, K Yamamoto, T Kobayashi, WV der Pol, T Horigome, H Yoshie, JG van de Winkel, K Hara |
Clinical & Experimental Immunology | 1999 |
No association between neutrophil FcgammaRIIa allelic polymorphism and anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis
WY Tse, S Abadeh, A McTiernan, R Jefferis, CO Savage, D Adu |
Clinical & Experimental Immunology | 1999 |
Fc gamma receptor IIIB-NA gene frequencies in patients with systemic lupus erythematosus and healthy individuals of Malay and Chinese ethnicity
SN Yap, ME Phipps, M Manivasagar, JJ Bosco |
Immunology Letters | 1999 |
Genetically determined aberrant down-regulation of Fc RIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus
Y Jiang, S Hirose, R Sanokawa-Akakura, M Abe, X Mi, N Li, Y Miura, J Shirai, D Zhang, Y Hamano, T Shirai |
International Immunology | 1999 |
Advances in Cellular and Molecular Biology of Membranes and Organelles
MA Horwitz, DL Clemens |
Advances in Cellular and Molecular Biology of Membranes and Organelles | 1999 |
Variant Genotypes of the Low-Affinity Fcγ Receptors in Two Control Populations and a Review of Low-Affinity Fcγ Receptor Polymorphisms in Control and Disease Populations
T Lehrnbecher, CB Foster, S Zhu, SF Leitman, LR Goldin, K Huppi, SJ Chanock |
Blood | 1999 |
Abnormal distribution of Fc? receptor type IIa polymorphisms in Korean patients with systemic lupus erythematosus
YW Song, CW Han, SW Kang, HJ Baek, EB Lee, CH Shin, BH Hahn, BP Tsao |
Arthritis & Rheumatism | 1998 |
FcγRIIA and FcγRIIIB polymorphisms in myasthenia gravis
G Raknes, GO Skeie, NE Gilhus, S Aadland, C Vedeler |
Journal of Neuroimmunology | 1998 |
NA1/NA2 Antisera Inhibit FcgammaRI-but Not FcgammaRII-Mediated Phagocytosis
BK Flesch, W Maass, J Neppert |
Vox Sanguinis | 1998 |
Visceral Ischemia and Neutrophil Activation in Sepsis and Organ Dysfunction
S Foulds, M Mireskandari, P Kalu, W Jackson, NJ Cheshire, AO Mansfield, M Schachter |
Journal of Surgical Research | 1998 |
FcγRIIIB Gene Duplication: Evidence for Presence and Expression of Three Distinct FcγRIIIB Genes in NA(1+,2+)SH(+) Individuals
HR Koene, M Kleijer, D Roos, M de Haas, AE dem Borne |
Blood | 1998 |
A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease
J Wu, JC Edberg, PB Redecha, V Bansal, PM Guyre, K Coleman, JE Salmon, RP Kimberly |
Journal of Clinical Investigation | 1997 |
IgG Binding Sites on Human FCγ Receptors
A Tamm, RE Schmidt |
International Reviews of Immunology | 1997 |
Clinical Relevance of Fc? Receptor Polymorphisms
A Rascu, R Repp, NA Westerdaal, JR Kalden, JG Winkel |
Annals of the New York Academy of Sciences | 1997 |
Human IgG Fc Receptors
IA Heijnen, JG van de Winkel |
International Reviews of Immunology | 1997 |
Relevance of immunoglobulin G Fc receptor polymorphism to recurrence of adult periodontitis in Japanese patients
T Kobayashi, NA Westerdaal, A Miyazaki, WL van der Pol, T Suzuki, H Yoshie, JG van de Winkel, K Hara |
Infection and immunity | 1997 |
Flow cytometric quantitation of attachment and phagocytosis in phenotypically-defined subpopulations of cells using PKH26-labeled FcγR-specific probes
L Pricop, JE Salmon, JC Edberg, AJ Beavis |
Journal of Immunological Methods | 1997 |
Saliva: a convenient source of DNA for analysis of bi-allelic polymorphisms of Fcγ receptor IIA (CD32) and Fcγ receptor IIIB (CD16)
RC van Schie, ME Wilson |
Journal of Immunological Methods | 1997 |
FcγRIIIa-158V/F Polymorphism Influences the Binding of IgG by Natural Killer Cell FcγRIIIa, Independently of the FcγRIIIa-48L/R/H Phenotype
HR Koene, M Kleijer, J Algra, D Roos, AE von dem Borne, M de Haas |
Blood | 1997 |
Characterization of a New Alloantigen (SH) on the Human Neutrophil Fcγreceptor IIIb
J Bux, EL Stein, P Bierling, P Fromont, M Clay, D Stroncek, S Santoso |
Blood | 1997 |
Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans
JE Salmon, S Millard, LA Schachter, FC Arnett, EM Ginzler, MF Gourley, R Ramsey-Goldman, MG Peterson, RP Kimberly |
Journal of Clinical Investigation | 1996 |
FcγRII and FcγRIII on normal and leukaemic granulocytes: A flow cytometry and northern analysis
A Kant, S Advani, S Zingde |
Leukemia Research | 1996 |
Role of allelic polymorphisms of Fcγ receptor IIa in systemic lupus erythematosus
JE Salmon |
Clinical Immunology Newsletter | 1996 |
The IgG Binding Site of Human FcRIIIB Receptor Involves CC′ and FG Loops of the Membrane-proximal Domain
A Tamm, A Kister, KU Nolte, JE Gessner, RE Schmidt |
The Journal of biological chemistry | 1996 |
Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner
JE Salmon, SS Millard, NL Brogle, RP Kimberly |
Journal of Clinical Investigation | 1995 |
Abnormal neutrophil phenotype and neutrophil FcRIII deficiency corrected by bone marrow transplantation
RM Minchinton, M Haas, AE Borne, M Kleijer, AW Roberts, EA Gillett |
Transfusion | 1995 |
Receptors for immunoglobulin g molecular diversity and implications for disease
RP Kimberly, JE Salmon, JC Edberg |
Arthritis & Rheumatism | 1995 |
The Ca 2+ Dependence of Human Fcγ Receptor-initiated Phagocytosis
JC Edberg, CT Lin, D Lau, JC Unkeless, RP Kimberly |
The Journal of biological chemistry | 1995 |
Ligand Binding and Phagocytosis by CD16 (Fc γ Receptor III) Isoforms
S Nagarajan, S Chesla, L Cobern, P Anderson, C Zhu, P Selvaraj |
The Journal of biological chemistry | 1995 |
Human immunoglobulin G (IgG) Fc receptor IIA (CD32) polymorphism and IgG2-mediated bacterial phagocytosis by neutrophils
LA Sanders, RG Feldman, MM Voorhorst-Ogink, M de Haas, GT Rijkers, PJ Capel, BJ Zegers, JG van de Winkel |
Infection and immunity | 1995 |
Genetic diversity in human Fc receptor II for immunoglobulin G: Fc gamma receptor IIA ligand-binding polymorphism
AF Reilly, CF Norris, S Surrey, FJ Bruchak, EF Rappaport, E Schwartz, SE McKenzie |
Clinical and diagnostic laboratory immunology | 1994 |
Role of neutrophil Fc gamma RIIa (CD32) and Fc gamma RIIIb (CD16) polymorphic forms in phagocytosis of human IgG1- and IgG3-opsonized bacteria and erythrocytes
RG Bredius, CA Fijen, MD Haas, EJ Kuijper, RS Weening, JG van de Winkel, TA Out |
Immunology | 1994 |
Surface expression and distribution of Fc receptor III (CD 16 molecule) on human natural killer cells and polymorphonuclear neutrophils
E Fern�ndez-Segura, JM Garc�a, JA L�pez-esc�mez, A Campos |
Microscopy Research and Technique | 1994 |
The biology and pathology of Fc receptors
M Sandor, RG Lynch |
Journal of Clinical Immunology | 1993 |
Fcγ receptor activation of neutrophils in cryoglobulin-induced leukocytoclastic vasculitis
M Hundt, M Zielinska-Skowronek, RE Schmidt |
Arthritis & Rheumatism | 1993 |
Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications
JG van de Winkel, PJ Capel |
Immunology Today | 1993 |
Macrophages and Related Cells
MA Horton |
1993 | |
Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function
JE Salmon, JC Edberg, NL Brogle, RP Kimberly |
Journal of Clinical Investigation | 1992 |
Surface expression of Fc gamma receptor III (CD16) on chemoattractant-stimulated neutrophils is determined by both surface shedding and translocation from intracellular storage compartments
MF Tosi, H Zakem |
Journal of Clinical Investigation | 1992 |
Novel Fc gamma receptor I family gene products in human mononuclear cells
AJ Porges, PB Redecha, R Doebele, LC Pan, JE Salmon, RP Kimberly |
Journal of Clinical Investigation | 1992 |
Functional capacity of Fcγ receptor III (CD16) on human neutrophils
JC Edberg, JE Salmon, RP Kimberly |
Immunologic Research | 1992 |
Receptor specific probes for the study of Fcγ receptor specific function
JC Edberg, RP Kimberly |
Journal of Immunological Methods | 1992 |
Polymorphism of the Human Fcγ Receptor II (CD32): Molecular Basis and Functional Aspects
PA Warmerdam, PW Parren, A Vlug, LA Aarden, JG van de Winkel, PJ Capel |
Immunobiology | 1992 |
Preferential expression of human Fc gamma RIIIPMN (CD16) in paroxysmal nocturnal hemoglobinuria. Discordant expression of glycosyl phosphatidylinositol-linked proteins
JC Edberg, JE Salmon, M Whitlow, RP Kimberly |
Journal of Clinical Investigation | 1991 |
Fc III receptors (FcRIII) on granulocytes: A specific and sensitive diagnostic test for paroxysmal nocturnal hemoglobinuria (PNH)
M Bessler, J Fehr |
European Journal of Haematology | 1991 |
Immunogenetic studies of soluble Fc receptor (CD 16) antigens in human seminal plasma
CJ Thaler, JA McIntyre, WP Faulk |
Tissue Antigens | 1991 |
Rheumatology
RA Asherson, R Cervera, DP D'Cruz, GR Hughes |
Postgraduate medical journal | 1991 |
5 Fc-gamma receptors: mediators, targets and markers of disease
TW Huizinga, D Roos, AE von Borne |
Baillière's Clinical Haematology | 1991 |
DEFICIENCY OF DAF AND CD16 ON PNH NEUTROPHILS
PA Veys, S Wilkes, G Ellis, AV Hoffbrand, M Bessler, J Fehr, Z Kawakami, H Ninomiya, J Tomiyama, T Abe |
British Journal of Haematology | 1990 |
Human immunodeficiency virus infection of monocytes: relationship to Fc-gamma receptors and antibody-dependent viral enhancement
J Laurence, A Saunders, E Early, JE Salmon |
Immunology | 1990 |
Hematology
JJ Shea, JJ Shea |
The Laryngoscope | 1949 |