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Citations to this article

Fc gamma receptor III on human neutrophils. Allelic variants have functionally distinct capacities.
J E Salmon, … , J C Edberg, R P Kimberly
J E Salmon, … , J C Edberg, R P Kimberly
Published April 1, 1990
Citation Information: J Clin Invest. 1990;85(4):1287-1295. https://doi.org/10.1172/JCI114566.
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Fc gamma receptor III on human neutrophils. Allelic variants have functionally distinct capacities.

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Abstract

As a model system to explore the functional consequences of structural variants of human Fc gamma receptors (Fc gamma R), we have investigated Fc gamma R-mediated phagocytosis in relation to the NA1-NA2 polymorphism of Fc gamma RIII (CD16) on neutrophils (Fc gamma RIIIPMN). The neutrophil-specific NA antigen system is a biallelic polymorphism with codominant expression demonstrating a gene dose effect with the anti-NA1 MAb CLB-gran 11 in a large donor population. To explore the impact of this allelic variation of Fc gamma RIIIPMN on phagocytosis, we used two Fc gamma RIII-dependent probes, IgG-sensitized erythrocytes (EA) and concanavalin. A-treated erythrocytes (E-ConA). Comparison of Fc gamma R-mediated phagocytosis by PMN from NA1 subjects and from NA2 subjects showed lower levels of phagocytosis of both probes by the NA2 individuals. The difference was most pronounced with lightly opsonized EA: at the lowest level of sensitization the phagocytic index was 72% lower for NA2 donors, whereas at the highest level of sensitization it was 21% lower (P less than 0.003). Blockade of Fc gamma RII with MAb IV.3 Fab amplified by threefold the difference between NA1 and NA2 donors. NA1 and NA2 individuals had identical phagocytic capacities for the non-Fc gamma RIII probes, serum-treated and heat-treated zymosan. These individuals did not show differential quantitative cell surface expression of Fc gamma RIIIPMN measured by a panel of anti-CD16 MAb (3G8, CLB FcR-gran 1, VEP13, BW209/2) and by Scatchard analysis of 125I-IgG dimer binding. The difference in Fc gamma R-mediated phagocytosis was not explicable on the basis of differential collaboration of Fc gamma RIIIPMN alleles with Fc gamma RII, since (a) the difference in phagocytic capacity between NA1 and NA2 individuals was readily apparent with the E-ConA probe (which is independent of Fc gamma RII) and (b) the difference in phagocytosis of EA was magnified by Fc gamma RII blockade. The demonstration that allelic polymorphisms in Fc gamma R can have significant consequences for physiological functions implies that within the structural complexity of human Fc gamma Rs, including both allelic forms and cell type-specific isoforms, there will be differences in quantitative, and perhaps qualitative, function with potential importance for disease processes.

Authors

J E Salmon, J C Edberg, R P Kimberly

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P Domingo, E Muñiz-Diaz, MA Baraldès, M Arilla, N Barquet, R Pericas, C Juárez, P Madoz, G Vázquez
The American Journal of Medicine 2002
Redox regulation of Fcgamma receptor-mediated phagocytosis: implications for host defense and tissue injury
L Pricop, JE Salmon
Antioxidants & Redox Signaling 2002
Diversity and duplicity: human FCgamma receptors in host defense and autoimmunity
RP Kimberly, J Wu, AW Gibson, K Su, H Qin, X Li, JC Edberg
Immunologic Research 2002
Patterns of low-affinity immunoglobulin receptor polymorphisms in stroke and homozygous sickle cell disease
JG VI, D Tang, CB Foster, GR Serjeant, GP Rodgers, SJ Chanock
American Journal of Hematology 2002
Fc? receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: Contribution ofFCGR2B to genetic susceptibility
C Kyogoku, HM Dijstelbloem, N Tsuchiya, Y Hatta, H Kato, A Yamaguchi, T Fukazawa, MD Jansen, H Hashimoto, JG van de Winkel, CG Kallenberg, K Tokunaga
Arthritis & Rheumatism 2002
The genetics of systemic lupus erythematosus: putting the pieces together
JA Kelly, KL Moser, JB Harley
Genes and Immunity 2002
Roles of Fc receptors in autoimmunity
T Takai
Nature Reviews Immunology 2002
The expression of NA antigens in people withunusual Fcgamma receptor III genotypes
K Matsuo, JL Procter, S Chanock, DF Stroncek
Transfusion 2001
Polymorphisms in inflammatory cytokines and Fcgamma receptors in childhood chronic immune thrombocytopenic purpura: a pilot study
CB Foster, S Zhu, HC Erichsen, T Lehrnbecher, ES Hart, E Choi, S Stein, MW Smith, SM Steinberg, P Imbach, T Kuhne, SJ Chanock
British Journal of Haematology 2001
Fcgamma receptors in autoimmune diseases
G Fossati, RC Bucknall, SW Edwards
European Journal of Clinical Investigation 2001
Soluble Fcγ receptor IIIb alters the function of polymorphonuclear neutrophils but extends their survival
V Durand, JO Pers, Y Renaudineau, P Youinou, C Jamin
European Journal of Immunology 2001
Transcription Factor NF??B Expression and Postsurgical Organ Dysfunction
S Foulds, C Galustian, AO Mansfield, M Schachter
Annals of Surgery 2001
Transcription factor NF kappa B expression and postsurgical organ dysfunction
S Foulds, C Galustian, AO Mansfield, M Schachter
Annals of Surgery 2001
FcγRIII b and FcγRIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy
S Taniuchi, M Masuda, A Yamamoto, M Hasui, S Tsuji, Y Komiyama, H Takahashi, Y Kobayashi
Human Immunology 2001
Frozen-stored granulocytes can be used for an immunofluorescence test to detect granulocyte antibodies
M Nishimura, S Mitsunaga, T Juji
Transfusion 2001
Inflammatory Diseases of Blood Vessels
G Hansson
Inflammatory Diseases of Blood Vessels: A Dialogue Between the Artery and the Immune System 2001
FcγRIIa/IIIa polymorphism and its association with clinical manifestations in Korean lupus patients
HR Yun, HK Koh, SS Kim, WT Chung, DW Kim, KP Hong, GG Song, HK Chang, JY Choe, SC Bae, JE Salmon, DH Yoo, TY Kim, SY Kim
Lupus 2001
FcγRIIa polymorphism in Japanese patients with systemic lupus erythematosus
H Sato, M Iwano, Y Akai, T Nishino, T Fujimoto, H Shiiki, K Dohi
Lupus 2001
Increased Frequency of FcγRIIIb-NA1 Allele in Periodontitis-resistant Subjects in an Elderly Japanese Population
N Sugita, T Kobayashi, Y Ando, A Yoshihara, K Yamamoto, JG de Winked, H Miyazaki, H Yoshie
Journal of dental research 2001
Bispecific Monoclonal Antibodies Mediate Binding of Dengue Virus to Erythrocytes in a Monkey Model of Passive Viremia
CS Hahn, OG French, P Foley, EN Martin, RP Taylor
Journal of immunology (Baltimore, Md. : 1950) 2001
C-reactive protein binding to FcγRIIa on human monocytes and neutrophils is allele-specific
MP Stein, JC Edberg, RP Kimberly, EK Mangan, D Bharadwaj, C Mold, TW du Clos
Journal of Clinical Investigation 2000
Variations in genes encoding neutrophil antigens NA1 and NA2
K Matsuo, J Procter, D Stroncek
Transfusion 2000
Association Between Fc RIIa-R131 Allotype and Bacteremic Pneumococcal Pneumonia
AM Yee, HM Phan, R Zuniga, JE Salmon, DM Musher
Clinical Infectious Diseases 2000
Lupus Susceptibility Genes on Human Chromosome 1
BR Tsao
International Reviews of Immunology 2000
Neutrophil FcgammaRIIIb allelic polymorphism in anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis
WY Tse, S Abadeh, R Jefferis, CO Savage, D Adu
Clinical & Experimental Immunology 2000
Effect of Allotype on Activation of Neutrophils by FcγRIIIB Cross-Linking
P Scott-Zaki, D Purkall, S Ruddy
Cellular Immunology 2000
IgG allotypes and subclasses in Norwegian patients with multiple sclerosis
G Raknes, JA Filho, JP Pandey, KM Myhr, E Ulvestad, H Nyland, CA Vedeler
Journal of the Neurological Sciences 2000
Nosocomial Pneumonia
UL Specks
Nosocomial Pneumonia 2000
Evaluation of Human FcγRIIA (CD32) and FcγRIIIB (CD16) Polymorphisms in Caucasians and African-Americans Using Salivary DNA
RC van Schie, ME Wilson
Clinical and diagnostic laboratory immunology 2000
Relevance of Fc gamma RIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients
N Sugita, K Yamamoto, T Kobayashi, WV der Pol, T Horigome, H Yoshie, JG van de Winkel, K Hara
Clinical & Experimental Immunology 1999
No association between neutrophil FcgammaRIIa allelic polymorphism and anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis
WY Tse, S Abadeh, A McTiernan, R Jefferis, CO Savage, D Adu
Clinical & Experimental Immunology 1999
Fc gamma receptor IIIB-NA gene frequencies in patients with systemic lupus erythematosus and healthy individuals of Malay and Chinese ethnicity
SN Yap, ME Phipps, M Manivasagar, JJ Bosco
Immunology Letters 1999
Genetically determined aberrant down-regulation of Fc RIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus
Y Jiang, S Hirose, R Sanokawa-Akakura, M Abe, X Mi, N Li, Y Miura, J Shirai, D Zhang, Y Hamano, T Shirai
International Immunology 1999
Advances in Cellular and Molecular Biology of Membranes and Organelles
MA Horwitz, DL Clemens
Advances in Cellular and Molecular Biology of Membranes and Organelles 1999
Variant Genotypes of the Low-Affinity Fcγ Receptors in Two Control Populations and a Review of Low-Affinity Fcγ Receptor Polymorphisms in Control and Disease Populations
T Lehrnbecher, CB Foster, S Zhu, SF Leitman, LR Goldin, K Huppi, SJ Chanock
Blood 1999
Abnormal distribution of Fc? receptor type IIa polymorphisms in Korean patients with systemic lupus erythematosus
YW Song, CW Han, SW Kang, HJ Baek, EB Lee, CH Shin, BH Hahn, BP Tsao
Arthritis & Rheumatism 1998
FcγRIIA and FcγRIIIB polymorphisms in myasthenia gravis
G Raknes, GO Skeie, NE Gilhus, S Aadland, C Vedeler
Journal of Neuroimmunology 1998
NA1/NA2 Antisera Inhibit FcgammaRI-but Not FcgammaRII-Mediated Phagocytosis
BK Flesch, W Maass, J Neppert
Vox Sanguinis 1998
Visceral Ischemia and Neutrophil Activation in Sepsis and Organ Dysfunction
S Foulds, M Mireskandari, P Kalu, W Jackson, NJ Cheshire, AO Mansfield, M Schachter
Journal of Surgical Research 1998
FcγRIIIB Gene Duplication: Evidence for Presence and Expression of Three Distinct FcγRIIIB Genes in NA(1+,2+)SH(+) Individuals
HR Koene, M Kleijer, D Roos, M de Haas, AE dem Borne
Blood 1998
A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease
J Wu, JC Edberg, PB Redecha, V Bansal, PM Guyre, K Coleman, JE Salmon, RP Kimberly
Journal of Clinical Investigation 1997
IgG Binding Sites on Human FCγ Receptors
A Tamm, RE Schmidt
International Reviews of Immunology 1997
Clinical Relevance of Fc? Receptor Polymorphisms
A Rascu, R Repp, NA Westerdaal, JR Kalden, JG Winkel
Annals of the New York Academy of Sciences 1997
Human IgG Fc Receptors
IA Heijnen, JG van de Winkel
International Reviews of Immunology 1997
Relevance of immunoglobulin G Fc receptor polymorphism to recurrence of adult periodontitis in Japanese patients
T Kobayashi, NA Westerdaal, A Miyazaki, WL van der Pol, T Suzuki, H Yoshie, JG van de Winkel, K Hara
Infection and immunity 1997
Flow cytometric quantitation of attachment and phagocytosis in phenotypically-defined subpopulations of cells using PKH26-labeled FcγR-specific probes
L Pricop, JE Salmon, JC Edberg, AJ Beavis
Journal of Immunological Methods 1997
Saliva: a convenient source of DNA for analysis of bi-allelic polymorphisms of Fcγ receptor IIA (CD32) and Fcγ receptor IIIB (CD16)
RC van Schie, ME Wilson
Journal of Immunological Methods 1997
FcγRIIIa-158V/F Polymorphism Influences the Binding of IgG by Natural Killer Cell FcγRIIIa, Independently of the FcγRIIIa-48L/R/H Phenotype
HR Koene, M Kleijer, J Algra, D Roos, AE von dem Borne, M de Haas
Blood 1997
Characterization of a New Alloantigen (SH) on the Human Neutrophil Fcγreceptor IIIb
J Bux, EL Stein, P Bierling, P Fromont, M Clay, D Stroncek, S Santoso
Blood 1997
Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans
JE Salmon, S Millard, LA Schachter, FC Arnett, EM Ginzler, MF Gourley, R Ramsey-Goldman, MG Peterson, RP Kimberly
Journal of Clinical Investigation 1996
FcγRII and FcγRIII on normal and leukaemic granulocytes: A flow cytometry and northern analysis
A Kant, S Advani, S Zingde
Leukemia Research 1996
Role of allelic polymorphisms of Fcγ receptor IIa in systemic lupus erythematosus
JE Salmon
Clinical Immunology Newsletter 1996
The IgG Binding Site of Human FcRIIIB Receptor Involves CC′ and FG Loops of the Membrane-proximal Domain
A Tamm, A Kister, KU Nolte, JE Gessner, RE Schmidt
The Journal of biological chemistry 1996
Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner
JE Salmon, SS Millard, NL Brogle, RP Kimberly
Journal of Clinical Investigation 1995
Abnormal neutrophil phenotype and neutrophil FcRIII deficiency corrected by bone marrow transplantation
RM Minchinton, M Haas, AE Borne, M Kleijer, AW Roberts, EA Gillett
Transfusion 1995
Receptors for immunoglobulin g molecular diversity and implications for disease
RP Kimberly, JE Salmon, JC Edberg
Arthritis & Rheumatism 1995
The Ca 2+ Dependence of Human Fcγ Receptor-initiated Phagocytosis
JC Edberg, CT Lin, D Lau, JC Unkeless, RP Kimberly
The Journal of biological chemistry 1995
Ligand Binding and Phagocytosis by CD16 (Fc γ Receptor III) Isoforms
S Nagarajan, S Chesla, L Cobern, P Anderson, C Zhu, P Selvaraj
The Journal of biological chemistry 1995
Human immunoglobulin G (IgG) Fc receptor IIA (CD32) polymorphism and IgG2-mediated bacterial phagocytosis by neutrophils
LA Sanders, RG Feldman, MM Voorhorst-Ogink, M de Haas, GT Rijkers, PJ Capel, BJ Zegers, JG van de Winkel
Infection and immunity 1995
Genetic diversity in human Fc receptor II for immunoglobulin G: Fc gamma receptor IIA ligand-binding polymorphism
AF Reilly, CF Norris, S Surrey, FJ Bruchak, EF Rappaport, E Schwartz, SE McKenzie
Clinical and diagnostic laboratory immunology 1994
Role of neutrophil Fc gamma RIIa (CD32) and Fc gamma RIIIb (CD16) polymorphic forms in phagocytosis of human IgG1- and IgG3-opsonized bacteria and erythrocytes
RG Bredius, CA Fijen, MD Haas, EJ Kuijper, RS Weening, JG van de Winkel, TA Out
Immunology 1994
Surface expression and distribution of Fc receptor III (CD 16 molecule) on human natural killer cells and polymorphonuclear neutrophils
E Fern�ndez-Segura, JM Garc�a, JA L�pez-esc�mez, A Campos
Microscopy Research and Technique 1994
The biology and pathology of Fc receptors
M Sandor, RG Lynch
Journal of Clinical Immunology 1993
Fcγ receptor activation of neutrophils in cryoglobulin-induced leukocytoclastic vasculitis
M Hundt, M Zielinska-Skowronek, RE Schmidt
Arthritis & Rheumatism 1993
Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications
JG van de Winkel, PJ Capel
Immunology Today 1993
Macrophages and Related Cells
MA Horton
1993
Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function
JE Salmon, JC Edberg, NL Brogle, RP Kimberly
Journal of Clinical Investigation 1992
Surface expression of Fc gamma receptor III (CD16) on chemoattractant-stimulated neutrophils is determined by both surface shedding and translocation from intracellular storage compartments
MF Tosi, H Zakem
Journal of Clinical Investigation 1992
Novel Fc gamma receptor I family gene products in human mononuclear cells
AJ Porges, PB Redecha, R Doebele, LC Pan, JE Salmon, RP Kimberly
Journal of Clinical Investigation 1992
Functional capacity of Fcγ receptor III (CD16) on human neutrophils
JC Edberg, JE Salmon, RP Kimberly
Immunologic Research 1992
Receptor specific probes for the study of Fcγ receptor specific function
JC Edberg, RP Kimberly
Journal of Immunological Methods 1992
Polymorphism of the Human Fcγ Receptor II (CD32): Molecular Basis and Functional Aspects
PA Warmerdam, PW Parren, A Vlug, LA Aarden, JG van de Winkel, PJ Capel
Immunobiology 1992
Preferential expression of human Fc gamma RIIIPMN (CD16) in paroxysmal nocturnal hemoglobinuria. Discordant expression of glycosyl phosphatidylinositol-linked proteins
JC Edberg, JE Salmon, M Whitlow, RP Kimberly
Journal of Clinical Investigation 1991
Fc III receptors (FcRIII) on granulocytes: A specific and sensitive diagnostic test for paroxysmal nocturnal hemoglobinuria (PNH)
M Bessler, J Fehr
European Journal of Haematology 1991
Immunogenetic studies of soluble Fc receptor (CD 16) antigens in human seminal plasma
CJ Thaler, JA McIntyre, WP Faulk
Tissue Antigens 1991
Rheumatology
RA Asherson, R Cervera, DP D'Cruz, GR Hughes
Postgraduate medical journal 1991
5 Fc-gamma receptors: mediators, targets and markers of disease
TW Huizinga, D Roos, AE von Borne
Baillière's Clinical Haematology 1991
DEFICIENCY OF DAF AND CD16 ON PNH NEUTROPHILS
PA Veys, S Wilkes, G Ellis, AV Hoffbrand, M Bessler, J Fehr, Z Kawakami, H Ninomiya, J Tomiyama, T Abe
British Journal of Haematology 1990
Human immunodeficiency virus infection of monocytes: relationship to Fc-gamma receptors and antibody-dependent viral enhancement
J Laurence, A Saunders, E Early, JE Salmon
Immunology 1990
Hematology
JJ Shea, JJ Shea
The Laryngoscope 1949

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