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Citations to this article

Stimulation of thrombopoiesis in mice by human recombinant interleukin 6.
R J Hill, … , M K Warren, J Levin
R J Hill, … , M K Warren, J Levin
Published April 1, 1990
Citation Information: J Clin Invest. 1990;85(4):1242-1247. https://doi.org/10.1172/JCI114559.
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Research Article

Stimulation of thrombopoiesis in mice by human recombinant interleukin 6.

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Abstract

To date, testing of various cytokines for the stimulation of blood cell production has not demonstrated a consistent effect on peripheral platelet levels. In this report, we provide evidence that human recombinant IL-6 increased platelet production in mice, as measured by both peripheral platelet levels and [75Se]selenomethionine (75SeM) incorporation into newly forming platelets. Peripheral white blood cell counts also were increased, but only to a modest extent, and hematocrit values were unchanged. A dose-response relationship between the amount of IL-6 administered and platelet count, 75SeM incorporation, and white blood cell count was demonstrated. Detectable megakaryocyte and granulocyte-macrophage colony-forming cells in mice that had received IL-6 also were increased in both bone marrow and spleen. These results demonstrate the ability of a purified, recombinant protein to stimulate platelet production in vivo.

Authors

R J Hill, M K Warren, J Levin

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Total citations by year

Year: 2024 2023 2020 2019 2015 2013 2011 2009 2008 2007 2006 2005 2003 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 Total
Citations: 1 1 2 1 1 1 2 2 2 1 2 1 1 3 2 1 5 2 6 14 11 5 10 3 2 82
Citation information
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