Leukotriene B4 (LTB4) is a major product of human alveolar macrophages and has potent chemotactic activity for neutrophils (PMN) in vitro. To evaluate the effects of LTB4 in the normal human lung, we instilled LTB4 (5 X 10(-7)M, 10 ml) into a subsegment of the right middle lobe and 0.9% NaCl (10 ml) into a subsegment of the lingula using a fiberoptic bronchoscope in 12 healthy human volunteers. 4 h later, we performed bronchoalveolar lavage of the same subsegments. Compared with the NaCl instillation, LTB4 caused a large increase in lavage total cells (NaCl = 6.8 +/- 1.0 X 10(6) vs. LTB4 = 26.4 +/- 5.0 X 10(6), P less than 0.01), most of which were PMN (NaCl = 12.2 +/- 4.6% vs. LTB4 = 55.7 +/- 6.0%, P less than 0.001). In contrast, there was only a small increase in lavage total protein, and the lavage total protein correlated weakly with lavage total cells and PMN. The production of superoxide anion by the lavage PMN in response to phorbol myristate acetate was similar to that of peripheral blood PMN. The migration of lavage PMN was normal toward the chemotactic peptide FMLP, but reduced toward LTB4 and zymosan-activated human serum. Morphometric analysis using transmission electron microscopy indicated a selective loss of small granules in the lung neutrophils as compared with peripheral blood neutrophils. The data indicate that in the normal human lung, LTB4 can recruit active PMN into the airspaces without causing a significant change in the protein permeability of the epithelial barrier.
T R Martin, B P Pistorese, E Y Chi, R B Goodman, M A Matthay
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Asthma and COPD | 2009 |
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MACROPHAGE MIGRATION INHIBITORY FACTOR WITHIN THE ALVEOLAR SPACES INDUCES CHANGES IN THE HEART DURING LATE EXPERIMENTAL SEPSIS
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American journal of respiratory and critical care medicine | 2005 |
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American journal of physiology. Lung cellular and molecular physiology | 2005 |
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Role of Neutrophils in Mucus Hypersecretion in COPD and Implications for Therapy
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Treatments in Respiratory Medicine | 2004 |
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Critical Care Medicine | 2004 |
Role of Neutrophils in Mucus Hypersecretion in COPD and Implications for Therapy:
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Treatments in Respiratory Medicine | 2004 |
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American journal of respiratory and critical care medicine | 2004 |
Direct lung injury by bacteria: Clarifying the tools of the trade*:
TR Martin |
Critical Care Medicine | 2004 |
Positron emission tomography with [ 18 F]fluorodeoxyglucose to evaluate neutrophil kinetics during acute lung injury
DL Chen, DP Schuster |
American journal of physiology. Lung cellular and molecular physiology | 2004 |
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G Allen, JH Bates |
Journal of applied physiology | 2004 |
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The Journal of trauma | 2004 |
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RB Goodman, J Pugin, JS Lee, MA Matthay |
Cytokine & Growth Factor Reviews | 2003 |
The role of apoptosis in acute lung injury
TR Martin, M Nakamura, G Matute-Bello |
Critical Care Medicine | 2003 |
BLT1 and BLT2: the leukotriene B4 receptors
AM Tager, AD Luster |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2003 |
Meconium Induces Only Localized Inflammatory Lung Injury in Piglets
K Korhonen, H Soukka, L Halkola, H Peuravuori, H Aho, K Pulkki, P Kero, PO Kääpä |
Pediatric Research | 2003 |
Lung Biology in Health and Disease
N Zamel |
Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential | 2003 |
Chemokines in the Lung
W Tsai, B Mehrad |
Chemokines in the Lung | 2003 |
Protein transport across the lung epithelial barrier
KJ Kim, AB Malik |
American journal of physiology. Lung cellular and molecular physiology | 2003 |
Elevated levels of leukotriene B4 and leukotriene E4 in bronchoalveolar lavage fluid from patients with scleroderma lung disease
O Kowal-Bielecka, O Distler, K Kowal, Z Siergiejko, J Chwieko, A Sulik, RE Gay, AB ukaszyk, S Gay, S Sierakowski |
Arthritis & Rheumatism | 2003 |
Regulation of Leukocyte Transmigration: Cell Surface Interactions and Signaling Events
Y Liu, SK Shaw, S Ma, L Yang, FW Luscinskas, CA Parkos |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
Neutrophils and lung injury: getting it right
TR Martin |
Journal of Clinical Investigation | 2002 |
A novel therapeutic strategy for attenuating neutrophil-mediated lung injury in vivo
S Sookhai, JJ Wang, M McCourt, W Kirwan, D Bouchier-Hayes, P Redmond |
Annals of Surgery | 2002 |
The pharmacogenetics of asthma and allergic disease
J Hjoberg, JM Drazen, LJ Palmer, ST Weiss, ES Silverman |
Immunology and Allergy Clinics of North America | 2002 |
Neutrophil Proteinases in Hydrochloric Acid- and Endotoxin-Induced Acute Lung Injury: Evaluation of Interstitial Protease Activity by in situ Zymography
AV de Louw, D Jean, E Frisdal, C Cerf, MP d'Ortho, AH Baker, C Lafuma, P Duvaldestin, A Harf, C Delclaux |
Laboratory Investigation | 2002 |
Increased Leukotrienes in Exhaled Breath Condensate in Childhood Asthma
Z Csoma, SA Kharitonov, B Balint, A Bush, NM Wilson, PJ Barnes |
American journal of respiratory and critical care medicine | 2002 |
Acute Lung Injury
GD Leikauf, SA McDowell, SC Wesselkamper, WD Hardie, JE Leikauf, TR Korfhagen, DR Prows |
Chest | 2002 |
Pulmonary Dysfunction After Cardiac Surgery
CS Ng, S Wan, AP Yim, AA Arifi |
Chest | 2002 |
A Randomized, Placebo-Controlled Trial of a Leukotriene Synthesis Inhibitor in Patients With COPD
S Gompertz, RA Stockley |
Chest | 2002 |
Invited Review: Alveolar edema fluid clearance in the injured lung
Y Berthiaume, HG Folkesson, MA Matthay |
Journal of applied physiology | 2002 |
Hepatocyte growth factor is produced by blood and alveolar neutrophils in acute respiratory failure
S Jaffré, M Dehoux, C Paugam, A Grenier, S Chollet-Martin, JB Stern, J Mantz, M Aubier, B Crestani |
American journal of physiology. Lung cellular and molecular physiology | 2002 |
Mechanisms of Organ Dysfunction in Critical Illness
TW Evans, MP Fink |
2002 | |
Community-Acquired Pneumonia
TJ Marrie |
2002 | |
Fas (CD95) Induces Alveolar Epithelial Cell Apoptosis in Vivo
G Matute-Bello, RK Winn, M Jonas, EY Chi, TR Martin, WC Liles |
The American Journal of Pathology | 2001 |
Neutrophil activation and acute lung injury
WL Lee, GP Downey |
Current Opinion in Critical Care | 2001 |
Efficacy of antileukotriene agents in asthma management
RA Nathan, JP Kemp |
Annals of Allergy Asthma & Immunology | 2001 |
Respiratory-Circulatory Interactions in Health and Disease: Formation and Reabsorption
M Matthay, T Sakuma |
Respiratory-Circulatory Interactions in Health and Disease | 2001 |
Local Inflammatory Responses following Bronchial Endotoxin Instillation in Humans
NP O'grady, HL Preas, J Pugin, C Fiuza, M Tropea, D Reda, SM Banks, AF Suffredini |
American journal of respiratory and critical care medicine | 2001 |
Leukocyte Elastase: Physiological Functions and Role in Acute Lung Injury
WL Lee, GP Downey |
American journal of respiratory and critical care medicine | 2001 |
Current treatment of asthma - focus on leukotrienes
SD Crowther, PJ Rees |
Expert Opinion on Pharmacotherapy | 2000 |
The role of eosinophils and neutrophils in inflammation
Sampson |
Clinical & Experimental Allergy | 2000 |
Novel therapy for COPD
TT Hansel, MJ Leckie, SA Bryan, PJ Barnes |
Expert Opinion on Investigational Drugs | 2000 |
ALVEOLAR EPITHELIAL BARRIER
MA Matthay, N Fukuda, J Frank, R Kallet, B Daniel, T Sakuma |
Clinics in Chest Medicine | 2000 |
Eicosapentaenoic Acid Reduces Pulmonary Edema in Endotoxemic Rats
S Sane, M Baba, C Kusano, K Shirao, T Andoh, T Kamada, T Aikou |
Journal of Surgical Research | 2000 |
Circulating neutrophil concentration and respiratory distress in premature infants
PJ Ferreira, TJ Bunch, KH Albertine, DP Carlton |
The Journal of Pediatrics | 2000 |
Neutrophil recruitment and increased permeability during acute lung injury induced by lipopolysaccharide
M Chignard, V Balloy |
American journal of physiology. Lung cellular and molecular physiology | 2000 |
The Metabolism of Leukotriene B 4 in Lewis Lung Carcinoma Porcine Kidney Cells
JA Hankin, RC Murphy |
American journal of respiratory and critical care medicine | 2000 |
Pharmacological Characterization of Leukotriene Receptors
SE Dahlén |
American journal of respiratory and critical care medicine | 2000 |
E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid
F Rose, L Kiss, F Grimminger, K Mayer, U Grandel, W Seeger, E Bieniek, U Sibelius |
American journal of physiology. Lung cellular and molecular physiology | 2000 |
Cellular Mechanisms in Airways Inflammation
CP Page, KH Banner, D Spina |
2000 | |
Yearbook of Intensive Care and Emergency Medicine 2000
JL Vincent |
2000 | |
Pathogenesis of increased sucrose permeability in H. pylori gastritis
D Y Graham |
Digestive Diseases and Sciences | 2000 |
Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia
K Kurahashi, O Kajikawa, T Sawa, M Ohara, MA Gropper, DW Frank, TR Martin, JP Wiener-Kronish |
Journal of Clinical Investigation | 1999 |
Biochemistry and physiology of the leukotrienes
NC Barnes, LJ Smith |
Clinical Reviews in Allergy & Immunology | 1999 |
PARTITIONING LUNG AND PLASMA PROTEINS: CIRCULATING SURFACTANT PROTEINS AS BIOMARKERS OF ALVEOLOCAPILLARY PERMEABILITY
IR Doyle, TE Nicholas, AD Bersten |
Clinical and Experimental Pharmacology and Physiology | 1999 |
Asthma and leukotrienes: antileukotrienes as novel anti-asthmatic drugs
HE Claesson, SE Dahlen |
Journal of Internal Medicine | 1999 |
Role of leukotrienes in antimicrobial host defense of the lung
M Peters-Golden, M Coffey |
Clinical Reviews in Allergy & Immunology | 1999 |
Synergistic effects of pranlukast and a leukotriene B4 receptor antagonist on antigen-induced pulmonary reaction
T Sakurada, M Abe, M Kodani, N Sakata, T Katsuragi |
European Journal of Pharmacology | 1999 |
New and Exploratory Therapeutic Agents for Asthma
R Djukanovi_ |
New and Exploratory Therapeutic Agents for Asthma | 1999 |
Segmental allergen challenge induces plasma protein leakage into the airways of asthmatic subjects at 4 hours but not at 5 minutes after challenge
RE Nocker, JS van der Zee, FR Weller, FJ van Overveld, HM Jansen, TA Out |
Journal of Laboratory and Clinical Medicine | 1999 |
LEUKOTRIENES, LEUKOTRIENE RECEPTOR ANTAGONISTS AND LEUKOTRIENE SYNTHESIS INHIBITORS IN ASTHMA: AN UPDATE. PART I: SYNTHESIS, RECEPTORS AND ROLE OF LEUKOTRIENES IN ASTHMA
P Devillier, N Baccard, C Advenier |
Pharmacological Research | 1999 |
Ambient Air Particles: Effects on Cellular Oxidant Radical Generation in Relation to Particulate Elemental Chemistry
AK Prahalad, JM Soukup, J Inmon, R Willis, AJ Ghio, S Becker, JE Gallagher |
Toxicology and Applied Pharmacology | 1999 |
Chemokines in Disease
CA Hébert |
1999 | |
Anti-Inflammatory Drugs in Asthma
AP Sampson, MK Church |
1999 | |
Novel Inhibitors of Leukotrienes
G Folco, B Samuelsson, RC Murphy |
1999 | |
Molecular Biology of the Lung
RA Stockley |
1999 | |
Comprehensive Asthma Management: Guidelines for Clinicians
JP Kemp |
Journal of Asthma | 1998 |
Exposure of healthy volunteers to swine house dust increases formation of leukotrienes, prostaglandin D2, and bronchial responsiveness to methacholine
S O'Sullivan, SE Dahlen, K Larsson, BM Larsson, P Malmberg, M Kumlin, L Palmberg |
Thorax | 1998 |
New therapies for chronic obstructive pulmonary disease
PJ Barnes |
Thorax | 1998 |
Effects of SA6541, a leukotriene A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis
F Tsuji, Y Miyake, H Enomoto, M Horiuchi, S Mita |
European Journal of Pharmacology | 1998 |
Contre un rôle majeur du polynucléaire neutrophile au cours du SDRA
C Delclaux |
Réanimation Urgences | 1998 |
Leukotrienes and Inflammation
WW Busse |
American journal of respiratory and critical care medicine | 1998 |
Involvement of Leukotriene B4 in Murine Dermatitis Models
F Tsuji, Y Miyake, M Horiuchi, S Mita |
Biochemical Pharmacology | 1998 |
Protective Effect of Endotoxin Instillation on Subsequent Bacteria-induced Acute Lung Injury in Rats
D Jean, S Rezaiguia-Delclaux, C Delacourt, R Leclercq, C Lafuma, C Brun-Buisson, A Harf, C Delclaux |
American journal of respiratory and critical care medicine | 1998 |
Inhaled leukotrienes cause bronchoconstriction and neutrophil accumulation in horses
KA Marr, P Lees, CP Page, FM Cunningham |
Research in Veterinary Science | 1998 |
The Effect of Endotoxin on in Vivo Rat Alveolar Macrophage Phagocytosis
CW Frevert, AE Warner, E Weller, JD Brain |
Experimental Lung Research | 1998 |
Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury
C Hierholzer, JC Kalff, L Omert, K Tsukada, JE Loeffert, SC Watkins, TR Billiar, DJ Tweardy |
American journal of physiology. Lung cellular and molecular physiology | 1998 |
Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP
JA Nick, NJ Avdi, SK Young, C Knall, P Gerwins, GL Johnson, GS Worthen |
Journal of Clinical Investigation | 1997 |
Decrease in Gastric Permeability to Sucrose Following Cure of Helicobacter pylori Infection
RW Goodgame, HM Malaty, HM El-Zimaity, DY Graham |
Helicobacter | 1997 |
The novel chemokine mob-1: Involvement in adult respiratory distress syndrome
F Abdullah, P Ovadia, G Feuerstein, LF Neville, R Morrison, G Mathiak, M Whiteford, R Rabinovici |
Surgery | 1997 |
Granules of the human neutrophilic polymorphonuclear leukocyte
N Borregaard, JB Cowland |
Blood | 1997 |
Neutrophil Apoptosis in the Acute Respiratory Distress Syndrome
G Matute-Bello, WC Liles, F Radella, KP Steinberg, JT Ruzinski, M Jonas, EY Chi, LD Hudson, TR Martin |
American journal of respiratory and critical care medicine | 1997 |
Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits
HG Folkesson, MA Matthay |
Journal of applied physiology | 1997 |
Leukotriene Activity Modulation in Asthma:
SL Spector |
Drugs | 1997 |
Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: A 6-month randomized multicenter trial
MC Liu, LM Dubé, J Lancaster |
Journal of Allergy and Clinical Immunology | 1996 |
NEW MODALITIES FOR THE PHARMACOTHERAPY OF ASTHMA
WR Henderson |
Immunology and Allergy Clinics of North America | 1996 |
Leukotriene B4 and asthma
PE Christie, NC Barnes |
Thorax | 1996 |
Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced responses in asthma
DJ Evans, PJ Barnes, SM Spaethe, EL van Alstyne, MI Mitchell, BJ O'Connor |
Thorax | 1996 |
ARDS Acute Respiratory Distress in Adults
TW Evans, C Haslett |
1996 | |
Clinical Management of Asthma in the 1990s: Current Therapy and New Directions
P Jain, JA Golish |
Drugs | 1996 |
Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms
HG Folkesson, MA Matthay, CA Hébert, VC Broaddus |
Journal of Clinical Investigation | 1995 |
Sputum peroxidase activity correlates with the severity of lung disease in cystic fibrosis
WE Regelmann, CM Siefferman, JM Herron, GR Elliott, CC Clawson, BH Gray |
Pediatric Pulmonology | 1995 |
Effects of pretreatment with SDZ MRL 953, a novel immunostimulatory lipid A analog, on endotoxin-induced acute lung injury in guinea pigs
H Nakamura, A Ishizaka, T Urano, K Sayama, F Sakamaki, T Terashima, Y Waki, K Soejima, S Tasaka, N Hasegawa |
Clinical and diagnostic laboratory immunology | 1995 |
Eicosanoids and asthma: an update
FC Thien, EH Walters |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 1995 |
Immunopharmacology of Free Radical Species
C Rice-Evans |
Immunopharmacology of Free Radical Species | 1995 |
Beneficial effects of a leukotriene receptor antagonist on thrombin-induced pulmonary edema in the rat
CM Ahn, H Sandler, T Saldeen |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 1995 |
Effect of Cotton, Hemp, and Flax Dust Extracts on Lung Permeability in the Guinea Pig
PJ Bates, SJ Farr, PJ Nicholls |
Experimental Lung Research | 1995 |
Leukotriene B4 in Bronchoalveolar Lavage Fluid of Patients With Diffuse Panbronchiolitis
H Oda, JI Kadota, S Kohno, K Hara |
Chest | 1995 |
Effect of an LTB4 Aerosol Exposure on Pulmonary Function, Cell Populations, and Mediators in the Lungs of Rhesus Monkeys
DL Allen, DR Herman, GD Williams, SM Spaethe, MA Dorato, RK Wolff |
Inhalation Toxicology | 1995 |
INFLAMMATION AND ASTHMA
RJ Horwitz, WW Busse |
Clinics in Chest Medicine | 1995 |
Helicobacter pylori
J Calam |
European Journal of Clinical Investigation | 1994 |
The absorption and effect of dietary supplementation with omega-3 fatty acids on serum leukotriene B4, in patients with cystic fibrosis
LE Kurlandsky, MR Bennink, PM Webb, PJ Ulrich, LJ Baer |
Pediatric Pulmonology | 1994 |
QSAR Study of ortho-phenylphenol leukotriene B4 receptor antagonists
JH Wikel, MJ Sofia, DL Saussy, KG Bemis |
Bioorganic & Medicinal Chemistry Letters | 1994 |
Toxoplasma gondii alters eicosanoid release by human mononuclear phagocytes: role of leukotrienes in interferon gamma-induced antitoxoplasma activity
EC Yong, EY Chi, WR Henderson |
Journal of Experimental Medicine | 1994 |
Oral absorption of omega-3 fatty acids in patients with cystic fibrosis who have pancreatic insufficiency and in healthy control subjects
WR Henderson, SJ Astley, MM McCready, P Kushmerick, S Casey, JW Becker, BW Ramsey |
The Journal of Pediatrics | 1994 |
Leukotriene Receptor Antagonists and Biosynthesis Inhibitors in Asthma: An Update
Z Diamant, JW Lammers, PJ Sterk |
Clinical immunotherapeutics | 1994 |
Pseudomonas aeruginosa Infections in Patients with Cystic Fibrosis: New Immunomodulatory Strategies
A Buret |
Clinical immunotherapeutics | 1994 |
Function of the Alveolar Epithelial Barrier Under Pathologic Conditions
MA Matthay |
Chest | 1994 |
Lung Mast Cells Increase in Number and Degranulate during Pulmonary Artery Occlusion/Reperfusion Injury in Dogs
M Su, EY Chi, MJ Bishop, WR Henderson |
American journal of respiratory and critical care medicine | 1993 |
Immunoglobulin E-mediated Increase in Vascular Permeability Correlates with Eosinophilic Inflammation
DS Collins, R Dupuis, GJ Gleich, KR Bartemes, YY Koh, M Pollice, KH Albertine, JE Fish, SP Peters |
American journal of respiratory and critical care medicine | 1993 |
Leukotriene B 4 Markedly Elevated in the Epithelial Lining Fluid of Patients with Cystic Fibrosis
MW Konstan, RW Walenga, KA Hilliard, JB Hilliard |
American journal of respiratory and critical care medicine | 1993 |
A Mechanism of Erythromycin Treatment in Patients with Diffuse Panbronchiolitis
J Kadota, O Sakito, S Kohno, H Sawa, H Mukae, H Oda, K Khiawakami, K Fukushima, K Hiratani, K Hara |
American journal of respiratory and critical care medicine | 1993 |
Neutrophils Recruited to the Lungs of Humans by Segmental Antigen Challenge Display a Reduced Chemotactic Response to Leukotriene B 4
YY Koh, R Dupuis, M Pollice, KH Albertine, JE Fish, SP Peters |
American journal of respiratory cell and molecular biology | 1993 |
Pharmacologic Modulation of Antigen-induced Pulmonary Responses in the Perfused Guinea Pig Lung
WM Selig, JE Tocker, SA Tannu, F Cerasoli, SK Durham |
American journal of respiratory and critical care medicine | 1993 |
WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity
D Grimes, RJ Sturm, LR Marinari, RP Carlson, JW Berkenkopf, JH Musser, AF Kreft, BM Weichman |
European Journal of Pharmacology | 1993 |
Oral Leukotriene Inhibitor (MK-886) Blocks Allergen-induced Airway Responses
BS Friedman, EH Bel, A Buntinx, W Tanaka, YH Han, S Shingo, R Spector, P Sterk |
American journal of respiratory and critical care medicine | 1993 |
Leukotriene B4 and lnterleukin-8 in Human Immunodeficiency Virus-related Pulmonary Disease
GY Lipschik, ME Doerfler, JA Kovacs, WD Travis, VA Andrawis, MG Lawrence, JR Dichter, FP Ognibene, JH Shelhamer |
Chest | 1993 |
Evidence of a role for mesothelial cell-derived interleukin 8 in the pathogenesis of asbestos-induced pleurisy in rabbits
AM Boylan, C Rüegg, KJ Kim, CA Hébert, JM Hoeffel, R Pytela, D Sheppard, IM Goldstein, VC Broaddus |
Journal of Clinical Investigation | 1992 |
Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide. Implications for cytokine production in normal and injured lungs
TR Martin, JC Mathison, PS Tobias, DJ Letúrcq, AM Moriarty, RJ Maunder, RJ Ulevitch |
Journal of Clinical Investigation | 1992 |
Decreased polymorphonuclear leucocyte chemotactic response to leukotriene B4 in cystic fibrosis
RH Lawrence, TC Sorrell |
Clinical & Experimental Immunology | 1992 |
Scientific perspectives on adult respiratory distress syndrome
JE Repine |
The Lancet | 1992 |
Enhanced leukotriene synthesis in leukocytes of atopic and asthmatic subjects
AP Sampson, RU Thomas, JF Costello, PJ Piper |
British Journal of Clinical Pharmacology | 1992 |
Hyperoxic Exposure in Humans
DE Griffith, JG Garcia, HL James, KS Callahan, S Iriana, D Holiday |
Chest | 1992 |
Decreased polymorphonuclear leucocyte chemotactic response to leukotriene B4 in cystic fibrosis.
Lawrence RH, Sorrelli TC |
Clinical & Experimental Immunology | 1992 |
Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin
JP Wiener-Kronish, KH Albertine, MA Matthay |
Journal of Clinical Investigation | 1991 |
Repeated episodes of C5a-induced neutrophil influx do not result in pulmonary fibrosis
JA Harris, DM Hyde, Q Wang, MY Stovall, SN Giri |
Inflammation | 1991 |
Granulocyte chemotaxis in the canine trachea: Inhibition by lipid mediator antagonists and systemic inhibitors
HG Johnson, ML McNee |
Agents and Actions | 1991 |
Concentrations of LTB4, LTC4, LTD4and LTE4in bronchiolitis due to respiratory syncytial virus
R Garofalo, RC Welliver, PL Ogra, DR Welliver |
Pediatric Allergy and Immunology | 1991 |
Release of leukotriene B4 from human neutrophils after interaction with nontypeable Haemophilus influenzae
R Garofalo, H Faden, S Sharma, PL Ogra |
Infection and immunity | 1991 |
Conference Summary
AB Cohen |
Annals of the New York Academy of Sciences | 1991 |
Bronchoscopy with Bronchoalveolar Lavage Causes Neutrophil Recruitment to the Lower Respiratory Tract
SG von Essen, RA Robbins, JR Spurzem, AB Thompson, SS Mcgranaghan, SI Rennard |
American journal of respiratory and critical care medicine | 1991 |
The Function of Lung and Blood Neutrophils in Patients with the Adult Respiratory Distress Syndrome: Implications for the Pathogenesis of Lung Infections
TR Martin, BP Pistorese, LD Hudson, RJ Maunder |
American journal of respiratory and critical care medicine | 1991 |
The antiinflammatory agent SC-41930 inhibits granulocyte infiltration of the rodent dermis induced by 6-trans-leukotriene B4
DJ Fretland, DL Widomski, CP Anglin, TS Gaginella |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 1991 |
Serum Leukotriene B4 Levels in Patients with Obstructive Pulmonary Disease
JS Seggev, WH TThornton, TE Edes |
Chest | 1991 |
Identification of two neutrophil chemotactic peptides produced by porcine alveolar macrophages
RB Goodman, JW Forstrom, SG Osborn, EY Chi, TR Martin |
The Journal of biological chemistry | 1991 |
Omega-oxidized leukotriene B4 detected in the broncho-alveolar lavage fluid of patients with non-cardiogenic pulmonary edema, but not in those with cardiogenic edema
W Seeger, F Grimminger, M Barden, G Becker, J Lohmeyer, D Heinrich, |
Intensive Care Medicine | 1991 |
Staphylococcus aureus enterotoxin B challenge of monkeys: correlation of plasma levels of arachidonic acid cascade products with occurrence of illness
M Jett, W Brinkley, R Neill, P Gemski, R Hunt |
Infection and immunity | 1990 |
Identification and biological activity of dihydro-leukotriene B4: A prominent metabolite of leukotriene B4 in the human lung
M Kumlin, JR Falck, J Raud, Y Harada, SE Dahlén, E Granström |
Biochemical and Biophysical Research Communications | 1990 |
Mechanisms and Mediators of the Adult Respiratory Distress Syndrome
JE Rinaldo, JW Christman |
Clinics in Chest Medicine | 1990 |
The mechanism of leukotriene B4 export from human polymorphonuclear leukocytes
BK Lam, L Gagnon, KF Austen, RJ Soberman |
The Journal of biological chemistry | 1990 |
Verhandlungen der Deutschen Gesellschaft für Innere Medizin
B Schlegel |
1962 |