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Citations to this article

Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability.
T R Martin, … , R B Goodman, M A Matthay
T R Martin, … , R B Goodman, M A Matthay
Published November 1, 1989
Citation Information: J Clin Invest. 1989;84(5):1609-1619. https://doi.org/10.1172/JCI114338.
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Research Article

Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability.

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Abstract

Leukotriene B4 (LTB4) is a major product of human alveolar macrophages and has potent chemotactic activity for neutrophils (PMN) in vitro. To evaluate the effects of LTB4 in the normal human lung, we instilled LTB4 (5 X 10(-7)M, 10 ml) into a subsegment of the right middle lobe and 0.9% NaCl (10 ml) into a subsegment of the lingula using a fiberoptic bronchoscope in 12 healthy human volunteers. 4 h later, we performed bronchoalveolar lavage of the same subsegments. Compared with the NaCl instillation, LTB4 caused a large increase in lavage total cells (NaCl = 6.8 +/- 1.0 X 10(6) vs. LTB4 = 26.4 +/- 5.0 X 10(6), P less than 0.01), most of which were PMN (NaCl = 12.2 +/- 4.6% vs. LTB4 = 55.7 +/- 6.0%, P less than 0.001). In contrast, there was only a small increase in lavage total protein, and the lavage total protein correlated weakly with lavage total cells and PMN. The production of superoxide anion by the lavage PMN in response to phorbol myristate acetate was similar to that of peripheral blood PMN. The migration of lavage PMN was normal toward the chemotactic peptide FMLP, but reduced toward LTB4 and zymosan-activated human serum. Morphometric analysis using transmission electron microscopy indicated a selective loss of small granules in the lung neutrophils as compared with peripheral blood neutrophils. The data indicate that in the normal human lung, LTB4 can recruit active PMN into the airspaces without causing a significant change in the protein permeability of the epithelial barrier.

Authors

T R Martin, B P Pistorese, E Y Chi, R B Goodman, M A Matthay

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Role of Neutrophils in Mucus Hypersecretion in COPD and Implications for Therapy
S Kim, JA Nadel
Treatments in Respiratory Medicine 2004
Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung
M Kotani, T Kotani, A Ishizaka, S Fujishima, H Koh, S Tasaka, M Sawafuji, E Ikeda, K Moriyama, Y Kotake, H Morisaki, N Aikawa, A Ohashi, K Matsushima, YC Huang, J Takeda
Critical Care Medicine 2004
Role of Neutrophils in Mucus Hypersecretion in COPD and Implications for Therapy:
S Kim, JA Nadel
Treatments in Respiratory Medicine 2004
Exhaled Breath Condensate Detects Markers of Pulmonary Inflammation after Cardiothoracic Surgery
ED Moloney, SE Mumby, R Gajdocsi, JH Cranshaw, SA Kharitonov, GJ Quinlan, MJ Griffiths
American journal of respiratory and critical care medicine 2004
Direct lung injury by bacteria: Clarifying the tools of the trade*:
TR Martin
Critical Care Medicine 2004
Positron emission tomography with [ 18 F]fluorodeoxyglucose to evaluate neutrophil kinetics during acute lung injury
DL Chen, DP Schuster
American journal of physiology. Lung cellular and molecular physiology 2004
Dynamic mechanical consequences of deep inflation in mice depend on type and degree of lung injury
G Allen, JH Bates
Journal of applied physiology 2004
Attenuation of Shock-Induced Acute Lung Injury by Sphingosine Kinase Inhibition:
C Lee, DZ Xu, E Feketeova, KB Kannan, JK Yun, EA Deitch, Z Fekete, DH Livingston, CJ Hauser
The Journal of trauma 2004
Cytokine-mediated inflammation in acute lung injury
RB Goodman, J Pugin, JS Lee, MA Matthay
Cytokine & Growth Factor Reviews 2003
The role of apoptosis in acute lung injury
TR Martin, M Nakamura, G Matute-Bello
Critical Care Medicine 2003
BLT1 and BLT2: the leukotriene B4 receptors
AM Tager, AD Luster
Prostaglandins, Leukotrienes and Essential Fatty Acids 2003
Meconium Induces Only Localized Inflammatory Lung Injury in Piglets
K Korhonen, H Soukka, L Halkola, H Peuravuori, H Aho, K Pulkki, P Kero, PO Kääpä
Pediatric Research 2003
Lung Biology in Health and Disease
N Zamel
Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential 2003
Chemokines in the Lung
W Tsai, B Mehrad
Chemokines in the Lung 2003
Protein transport across the lung epithelial barrier
KJ Kim, AB Malik
American journal of physiology. Lung cellular and molecular physiology 2003
Elevated levels of leukotriene B4 and leukotriene E4 in bronchoalveolar lavage fluid from patients with scleroderma lung disease
O Kowal-Bielecka, O Distler, K Kowal, Z Siergiejko, J Chwieko, A Sulik, RE Gay, AB ukaszyk, S Gay, S Sierakowski
Arthritis & Rheumatism 2003
Regulation of Leukocyte Transmigration: Cell Surface Interactions and Signaling Events
Y Liu, SK Shaw, S Ma, L Yang, FW Luscinskas, CA Parkos
Journal of immunology (Baltimore, Md. : 1950) 2003
Neutrophils and lung injury: getting it right
TR Martin
Journal of Clinical Investigation 2002
A novel therapeutic strategy for attenuating neutrophil-mediated lung injury in vivo
S Sookhai, JJ Wang, M McCourt, W Kirwan, D Bouchier-Hayes, P Redmond
Annals of Surgery 2002
The pharmacogenetics of asthma and allergic disease
J Hjoberg, JM Drazen, LJ Palmer, ST Weiss, ES Silverman
Immunology and Allergy Clinics of North America 2002
Neutrophil Proteinases in Hydrochloric Acid- and Endotoxin-Induced Acute Lung Injury: Evaluation of Interstitial Protease Activity by in situ Zymography
AV de Louw, D Jean, E Frisdal, C Cerf, MP d'Ortho, AH Baker, C Lafuma, P Duvaldestin, A Harf, C Delclaux
Laboratory Investigation 2002
Increased Leukotrienes in Exhaled Breath Condensate in Childhood Asthma
Z Csoma, SA Kharitonov, B Balint, A Bush, NM Wilson, PJ Barnes
American journal of respiratory and critical care medicine 2002
Acute Lung Injury
GD Leikauf, SA McDowell, SC Wesselkamper, WD Hardie, JE Leikauf, TR Korfhagen, DR Prows
Chest 2002
Pulmonary Dysfunction After Cardiac Surgery
CS Ng, S Wan, AP Yim, AA Arifi
Chest 2002
A Randomized, Placebo-Controlled Trial of a Leukotriene Synthesis Inhibitor in Patients With COPD
S Gompertz, RA Stockley
Chest 2002
Invited Review: Alveolar edema fluid clearance in the injured lung
Y Berthiaume, HG Folkesson, MA Matthay
Journal of applied physiology 2002
Hepatocyte growth factor is produced by blood and alveolar neutrophils in acute respiratory failure
S Jaffré, M Dehoux, C Paugam, A Grenier, S Chollet-Martin, JB Stern, J Mantz, M Aubier, B Crestani
American journal of physiology. Lung cellular and molecular physiology 2002
Mechanisms of Organ Dysfunction in Critical Illness
TW Evans, MP Fink
2002
Community-Acquired Pneumonia
TJ Marrie
2002
Fas (CD95) Induces Alveolar Epithelial Cell Apoptosis in Vivo
G Matute-Bello, RK Winn, M Jonas, EY Chi, TR Martin, WC Liles
The American Journal of Pathology 2001
Neutrophil activation and acute lung injury
WL Lee, GP Downey
Current Opinion in Critical Care 2001
Efficacy of antileukotriene agents in asthma management
RA Nathan, JP Kemp
Annals of Allergy Asthma & Immunology 2001
Respiratory-Circulatory Interactions in Health and Disease: Formation and Reabsorption
M Matthay, T Sakuma
Respiratory-Circulatory Interactions in Health and Disease 2001
Local Inflammatory Responses following Bronchial Endotoxin Instillation in Humans
NP O'grady, HL Preas, J Pugin, C Fiuza, M Tropea, D Reda, SM Banks, AF Suffredini
American journal of respiratory and critical care medicine 2001
Leukocyte Elastase: Physiological Functions and Role in Acute Lung Injury
WL Lee, GP Downey
American journal of respiratory and critical care medicine 2001
Current treatment of asthma - focus on leukotrienes
SD Crowther, PJ Rees
Expert Opinion on Pharmacotherapy 2000
The role of eosinophils and neutrophils in inflammation
Sampson
Clinical & Experimental Allergy 2000
Novel therapy for COPD
TT Hansel, MJ Leckie, SA Bryan, PJ Barnes
Expert Opinion on Investigational Drugs 2000
ALVEOLAR EPITHELIAL BARRIER
MA Matthay, N Fukuda, J Frank, R Kallet, B Daniel, T Sakuma
Clinics in Chest Medicine 2000
Eicosapentaenoic Acid Reduces Pulmonary Edema in Endotoxemic Rats
S Sane, M Baba, C Kusano, K Shirao, T Andoh, T Kamada, T Aikou
Journal of Surgical Research 2000
Circulating neutrophil concentration and respiratory distress in premature infants
PJ Ferreira, TJ Bunch, KH Albertine, DP Carlton
The Journal of Pediatrics 2000
Neutrophil recruitment and increased permeability during acute lung injury induced by lipopolysaccharide
M Chignard, V Balloy
American journal of physiology. Lung cellular and molecular physiology 2000
The Metabolism of Leukotriene B 4 in Lewis Lung Carcinoma Porcine Kidney Cells
JA Hankin, RC Murphy
American journal of respiratory and critical care medicine 2000
Pharmacological Characterization of Leukotriene Receptors
SE Dahlén
American journal of respiratory and critical care medicine 2000
E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid
F Rose, L Kiss, F Grimminger, K Mayer, U Grandel, W Seeger, E Bieniek, U Sibelius
American journal of physiology. Lung cellular and molecular physiology 2000
Cellular Mechanisms in Airways Inflammation
CP Page, KH Banner, D Spina
2000
Yearbook of Intensive Care and Emergency Medicine 2000
JL Vincent
2000
Pathogenesis of increased sucrose permeability in H. pylori gastritis
D Y Graham
Digestive Diseases and Sciences 2000
Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia
K Kurahashi, O Kajikawa, T Sawa, M Ohara, MA Gropper, DW Frank, TR Martin, JP Wiener-Kronish
Journal of Clinical Investigation 1999
Biochemistry and physiology of the leukotrienes
NC Barnes, LJ Smith
Clinical Reviews in Allergy & Immunology 1999
PARTITIONING LUNG AND PLASMA PROTEINS: CIRCULATING SURFACTANT PROTEINS AS BIOMARKERS OF ALVEOLOCAPILLARY PERMEABILITY
IR Doyle, TE Nicholas, AD Bersten
Clinical and Experimental Pharmacology and Physiology 1999
Asthma and leukotrienes: antileukotrienes as novel anti-asthmatic drugs
HE Claesson, SE Dahlen
Journal of Internal Medicine 1999
Role of leukotrienes in antimicrobial host defense of the lung
M Peters-Golden, M Coffey
Clinical Reviews in Allergy & Immunology 1999
Synergistic effects of pranlukast and a leukotriene B4 receptor antagonist on antigen-induced pulmonary reaction
T Sakurada, M Abe, M Kodani, N Sakata, T Katsuragi
European Journal of Pharmacology 1999
New and Exploratory Therapeutic Agents for Asthma
R Djukanovi_
New and Exploratory Therapeutic Agents for Asthma 1999
Segmental allergen challenge induces plasma protein leakage into the airways of asthmatic subjects at 4 hours but not at 5 minutes after challenge
RE Nocker, JS van der Zee, FR Weller, FJ van Overveld, HM Jansen, TA Out
Journal of Laboratory and Clinical Medicine 1999
LEUKOTRIENES, LEUKOTRIENE RECEPTOR ANTAGONISTS AND LEUKOTRIENE SYNTHESIS INHIBITORS IN ASTHMA: AN UPDATE. PART I: SYNTHESIS, RECEPTORS AND ROLE OF LEUKOTRIENES IN ASTHMA
P Devillier, N Baccard, C Advenier
Pharmacological Research 1999
Ambient Air Particles: Effects on Cellular Oxidant Radical Generation in Relation to Particulate Elemental Chemistry
AK Prahalad, JM Soukup, J Inmon, R Willis, AJ Ghio, S Becker, JE Gallagher
Toxicology and Applied Pharmacology 1999
Chemokines in Disease
CA Hébert
1999
Anti-Inflammatory Drugs in Asthma
AP Sampson, MK Church
1999
Novel Inhibitors of Leukotrienes
G Folco, B Samuelsson, RC Murphy
1999
Molecular Biology of the Lung
RA Stockley
1999
Comprehensive Asthma Management: Guidelines for Clinicians
JP Kemp
Journal of Asthma 1998
Exposure of healthy volunteers to swine house dust increases formation of leukotrienes, prostaglandin D2, and bronchial responsiveness to methacholine
S O'Sullivan, SE Dahlen, K Larsson, BM Larsson, P Malmberg, M Kumlin, L Palmberg
Thorax 1998
New therapies for chronic obstructive pulmonary disease
PJ Barnes
Thorax 1998
Effects of SA6541, a leukotriene A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis
F Tsuji, Y Miyake, H Enomoto, M Horiuchi, S Mita
European Journal of Pharmacology 1998
Contre un rôle majeur du polynucléaire neutrophile au cours du SDRA
C Delclaux
Réanimation Urgences 1998
Leukotrienes and Inflammation
WW Busse
American journal of respiratory and critical care medicine 1998
Involvement of Leukotriene B4 in Murine Dermatitis Models
F Tsuji, Y Miyake, M Horiuchi, S Mita
Biochemical Pharmacology 1998
Protective Effect of Endotoxin Instillation on Subsequent Bacteria-induced Acute Lung Injury in Rats
D Jean, S Rezaiguia-Delclaux, C Delacourt, R Leclercq, C Lafuma, C Brun-Buisson, A Harf, C Delclaux
American journal of respiratory and critical care medicine 1998
Inhaled leukotrienes cause bronchoconstriction and neutrophil accumulation in horses
KA Marr, P Lees, CP Page, FM Cunningham
Research in Veterinary Science 1998
The Effect of Endotoxin on in Vivo Rat Alveolar Macrophage Phagocytosis
CW Frevert, AE Warner, E Weller, JD Brain
Experimental Lung Research 1998
Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury
C Hierholzer, JC Kalff, L Omert, K Tsukada, JE Loeffert, SC Watkins, TR Billiar, DJ Tweardy
American journal of physiology. Lung cellular and molecular physiology 1998
Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP
JA Nick, NJ Avdi, SK Young, C Knall, P Gerwins, GL Johnson, GS Worthen
Journal of Clinical Investigation 1997
Decrease in Gastric Permeability to Sucrose Following Cure of Helicobacter pylori Infection
RW Goodgame, HM Malaty, HM El-Zimaity, DY Graham
Helicobacter 1997
The novel chemokine mob-1: Involvement in adult respiratory distress syndrome
F Abdullah, P Ovadia, G Feuerstein, LF Neville, R Morrison, G Mathiak, M Whiteford, R Rabinovici
Surgery 1997
Granules of the human neutrophilic polymorphonuclear leukocyte
N Borregaard, JB Cowland
Blood 1997
Neutrophil Apoptosis in the Acute Respiratory Distress Syndrome
G Matute-Bello, WC Liles, F Radella, KP Steinberg, JT Ruzinski, M Jonas, EY Chi, LD Hudson, TR Martin
American journal of respiratory and critical care medicine 1997
Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits
HG Folkesson, MA Matthay
Journal of applied physiology 1997
Leukotriene Activity Modulation in Asthma:
SL Spector
Drugs 1997
Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: A 6-month randomized multicenter trial
MC Liu, LM Dubé, J Lancaster
Journal of Allergy and Clinical Immunology 1996
NEW MODALITIES FOR THE PHARMACOTHERAPY OF ASTHMA
WR Henderson
Immunology and Allergy Clinics of North America 1996
Leukotriene B4 and asthma
PE Christie, NC Barnes
Thorax 1996
Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced responses in asthma
DJ Evans, PJ Barnes, SM Spaethe, EL van Alstyne, MI Mitchell, BJ O'Connor
Thorax 1996
ARDS Acute Respiratory Distress in Adults
TW Evans, C Haslett
1996
Clinical Management of Asthma in the 1990s: Current Therapy and New Directions
P Jain, JA Golish
Drugs 1996
Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms
HG Folkesson, MA Matthay, CA Hébert, VC Broaddus
Journal of Clinical Investigation 1995
Sputum peroxidase activity correlates with the severity of lung disease in cystic fibrosis
WE Regelmann, CM Siefferman, JM Herron, GR Elliott, CC Clawson, BH Gray
Pediatric Pulmonology 1995
Effects of pretreatment with SDZ MRL 953, a novel immunostimulatory lipid A analog, on endotoxin-induced acute lung injury in guinea pigs
H Nakamura, A Ishizaka, T Urano, K Sayama, F Sakamaki, T Terashima, Y Waki, K Soejima, S Tasaka, N Hasegawa
Clinical and diagnostic laboratory immunology 1995
Eicosanoids and asthma: an update
FC Thien, EH Walters
Prostaglandins, Leukotrienes and Essential Fatty Acids 1995
Immunopharmacology of Free Radical Species
C Rice-Evans
Immunopharmacology of Free Radical Species 1995
Beneficial effects of a leukotriene receptor antagonist on thrombin-induced pulmonary edema in the rat
CM Ahn, H Sandler, T Saldeen
Prostaglandins, Leukotrienes and Essential Fatty Acids 1995
Effect of Cotton, Hemp, and Flax Dust Extracts on Lung Permeability in the Guinea Pig
PJ Bates, SJ Farr, PJ Nicholls
Experimental Lung Research 1995
Leukotriene B4 in Bronchoalveolar Lavage Fluid of Patients With Diffuse Panbronchiolitis
H Oda, JI Kadota, S Kohno, K Hara
Chest 1995
Effect of an LTB4 Aerosol Exposure on Pulmonary Function, Cell Populations, and Mediators in the Lungs of Rhesus Monkeys
DL Allen, DR Herman, GD Williams, SM Spaethe, MA Dorato, RK Wolff
Inhalation Toxicology 1995
INFLAMMATION AND ASTHMA
RJ Horwitz, WW Busse
Clinics in Chest Medicine 1995
Helicobacter pylori
J Calam
European Journal of Clinical Investigation 1994
The absorption and effect of dietary supplementation with omega-3 fatty acids on serum leukotriene B4, in patients with cystic fibrosis
LE Kurlandsky, MR Bennink, PM Webb, PJ Ulrich, LJ Baer
Pediatric Pulmonology 1994
QSAR Study of ortho-phenylphenol leukotriene B4 receptor antagonists
JH Wikel, MJ Sofia, DL Saussy, KG Bemis
Bioorganic & Medicinal Chemistry Letters 1994
Toxoplasma gondii alters eicosanoid release by human mononuclear phagocytes: role of leukotrienes in interferon gamma-induced antitoxoplasma activity
EC Yong, EY Chi, WR Henderson
Journal of Experimental Medicine 1994
Oral absorption of omega-3 fatty acids in patients with cystic fibrosis who have pancreatic insufficiency and in healthy control subjects
WR Henderson, SJ Astley, MM McCready, P Kushmerick, S Casey, JW Becker, BW Ramsey
The Journal of Pediatrics 1994
Leukotriene Receptor Antagonists and Biosynthesis Inhibitors in Asthma: An Update
Z Diamant, JW Lammers, PJ Sterk
Clinical immunotherapeutics 1994
Pseudomonas aeruginosa Infections in Patients with Cystic Fibrosis: New Immunomodulatory Strategies
A Buret
Clinical immunotherapeutics 1994
Function of the Alveolar Epithelial Barrier Under Pathologic Conditions
MA Matthay
Chest 1994
Lung Mast Cells Increase in Number and Degranulate during Pulmonary Artery Occlusion/Reperfusion Injury in Dogs
M Su, EY Chi, MJ Bishop, WR Henderson
American journal of respiratory and critical care medicine 1993
Immunoglobulin E-mediated Increase in Vascular Permeability Correlates with Eosinophilic Inflammation
DS Collins, R Dupuis, GJ Gleich, KR Bartemes, YY Koh, M Pollice, KH Albertine, JE Fish, SP Peters
American journal of respiratory and critical care medicine 1993
Leukotriene B 4 Markedly Elevated in the Epithelial Lining Fluid of Patients with Cystic Fibrosis
MW Konstan, RW Walenga, KA Hilliard, JB Hilliard
American journal of respiratory and critical care medicine 1993
A Mechanism of Erythromycin Treatment in Patients with Diffuse Panbronchiolitis
J Kadota, O Sakito, S Kohno, H Sawa, H Mukae, H Oda, K Khiawakami, K Fukushima, K Hiratani, K Hara
American journal of respiratory and critical care medicine 1993
Neutrophils Recruited to the Lungs of Humans by Segmental Antigen Challenge Display a Reduced Chemotactic Response to Leukotriene B 4
YY Koh, R Dupuis, M Pollice, KH Albertine, JE Fish, SP Peters
American journal of respiratory cell and molecular biology 1993
Pharmacologic Modulation of Antigen-induced Pulmonary Responses in the Perfused Guinea Pig Lung
WM Selig, JE Tocker, SA Tannu, F Cerasoli, SK Durham
American journal of respiratory and critical care medicine 1993
WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity
D Grimes, RJ Sturm, LR Marinari, RP Carlson, JW Berkenkopf, JH Musser, AF Kreft, BM Weichman
European Journal of Pharmacology 1993
Oral Leukotriene Inhibitor (MK-886) Blocks Allergen-induced Airway Responses
BS Friedman, EH Bel, A Buntinx, W Tanaka, YH Han, S Shingo, R Spector, P Sterk
American journal of respiratory and critical care medicine 1993
Leukotriene B4 and lnterleukin-8 in Human Immunodeficiency Virus-related Pulmonary Disease
GY Lipschik, ME Doerfler, JA Kovacs, WD Travis, VA Andrawis, MG Lawrence, JR Dichter, FP Ognibene, JH Shelhamer
Chest 1993
Evidence of a role for mesothelial cell-derived interleukin 8 in the pathogenesis of asbestos-induced pleurisy in rabbits
AM Boylan, C Rüegg, KJ Kim, CA Hébert, JM Hoeffel, R Pytela, D Sheppard, IM Goldstein, VC Broaddus
Journal of Clinical Investigation 1992
Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide. Implications for cytokine production in normal and injured lungs
TR Martin, JC Mathison, PS Tobias, DJ Letúrcq, AM Moriarty, RJ Maunder, RJ Ulevitch
Journal of Clinical Investigation 1992
Decreased polymorphonuclear leucocyte chemotactic response to leukotriene B4 in cystic fibrosis
RH Lawrence, TC Sorrell
Clinical & Experimental Immunology 1992
Scientific perspectives on adult respiratory distress syndrome
JE Repine
The Lancet 1992
Enhanced leukotriene synthesis in leukocytes of atopic and asthmatic subjects
AP Sampson, RU Thomas, JF Costello, PJ Piper
British Journal of Clinical Pharmacology 1992
Hyperoxic Exposure in Humans
DE Griffith, JG Garcia, HL James, KS Callahan, S Iriana, D Holiday
Chest 1992
Decreased polymorphonuclear leucocyte chemotactic response to leukotriene B4 in cystic fibrosis.
Lawrence RH, Sorrelli TC
Clinical & Experimental Immunology 1992
Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin
JP Wiener-Kronish, KH Albertine, MA Matthay
Journal of Clinical Investigation 1991
Repeated episodes of C5a-induced neutrophil influx do not result in pulmonary fibrosis
JA Harris, DM Hyde, Q Wang, MY Stovall, SN Giri
Inflammation 1991
Granulocyte chemotaxis in the canine trachea: Inhibition by lipid mediator antagonists and systemic inhibitors
HG Johnson, ML McNee
Agents and Actions 1991
Concentrations of LTB4, LTC4, LTD4and LTE4in bronchiolitis due to respiratory syncytial virus
R Garofalo, RC Welliver, PL Ogra, DR Welliver
Pediatric Allergy and Immunology 1991
Release of leukotriene B4 from human neutrophils after interaction with nontypeable Haemophilus influenzae
R Garofalo, H Faden, S Sharma, PL Ogra
Infection and immunity 1991
Conference Summary
AB Cohen
Annals of the New York Academy of Sciences 1991
Bronchoscopy with Bronchoalveolar Lavage Causes Neutrophil Recruitment to the Lower Respiratory Tract
SG von Essen, RA Robbins, JR Spurzem, AB Thompson, SS Mcgranaghan, SI Rennard
American journal of respiratory and critical care medicine 1991
The Function of Lung and Blood Neutrophils in Patients with the Adult Respiratory Distress Syndrome: Implications for the Pathogenesis of Lung Infections
TR Martin, BP Pistorese, LD Hudson, RJ Maunder
American journal of respiratory and critical care medicine 1991
The antiinflammatory agent SC-41930 inhibits granulocyte infiltration of the rodent dermis induced by 6-trans-leukotriene B4
DJ Fretland, DL Widomski, CP Anglin, TS Gaginella
Prostaglandins, Leukotrienes and Essential Fatty Acids 1991
Serum Leukotriene B4 Levels in Patients with Obstructive Pulmonary Disease
JS Seggev, WH TThornton, TE Edes
Chest 1991
Identification of two neutrophil chemotactic peptides produced by porcine alveolar macrophages
RB Goodman, JW Forstrom, SG Osborn, EY Chi, TR Martin
The Journal of biological chemistry 1991
Omega-oxidized leukotriene B4 detected in the broncho-alveolar lavage fluid of patients with non-cardiogenic pulmonary edema, but not in those with cardiogenic edema
W Seeger, F Grimminger, M Barden, G Becker, J Lohmeyer, D Heinrich,
Intensive Care Medicine 1991
Staphylococcus aureus enterotoxin B challenge of monkeys: correlation of plasma levels of arachidonic acid cascade products with occurrence of illness
M Jett, W Brinkley, R Neill, P Gemski, R Hunt
Infection and immunity 1990
Identification and biological activity of dihydro-leukotriene B4: A prominent metabolite of leukotriene B4 in the human lung
M Kumlin, JR Falck, J Raud, Y Harada, SE Dahlén, E Granström
Biochemical and Biophysical Research Communications 1990
Mechanisms and Mediators of the Adult Respiratory Distress Syndrome
JE Rinaldo, JW Christman
Clinics in Chest Medicine 1990
The mechanism of leukotriene B4 export from human polymorphonuclear leukocytes
BK Lam, L Gagnon, KF Austen, RJ Soberman
The Journal of biological chemistry 1990
Verhandlungen der Deutschen Gesellschaft für Innere Medizin
B Schlegel
1962

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