Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Sulfated beef insulin treatment elicits CD8+ T cells that may abrogate immunologic insulin resistance in type I diabetes.
P Naquet, … , J W Semple, T L Delovitch
P Naquet, … , J W Semple, T L Delovitch
Published November 1, 1989
Citation Information: J Clin Invest. 1989;84(5):1479-1487. https://doi.org/10.1172/JCI114323.
View: Text | PDF
Research Article Article has an altmetric score of 3

Sulfated beef insulin treatment elicits CD8+ T cells that may abrogate immunologic insulin resistance in type I diabetes.

  • Text
  • PDF
Abstract

The in vitro responses of T cells from 13 insulin-nonresistant and 1 immunologically insulin-resistant (IIR) type I diabetes patients to sulfated beef insulin (SBI) were analyzed. Insulin A-loop specific CD4+ T cells from these patients did not respond to SBI. After 1 yr of treatment with SBI the IIR patient's T cell and antibody responses to beef, pork, and human insulin progressed from very high to nondetectable levels. This occurred in parallel to the appearance of her insulin-specific CD8+ T cells, which inhibited the response of her A-loop-specific CD4+ T cells to insulin. A transient increase in her CD8+ anti-insulin antibody activity coincided with a relative lack of her CD8+ T cell activity. CD8+ T cells that regulate T cell responsiveness to insulin are probably present but difficult to detect in most type I diabetes patients. These T cells were identified in only 2 of 13 insulin-nonresistant patients who presented with lipoatrophy and insulin allergy, respectively, and who possessed high-titered, anti-insulin antibodies. Our data demonstrate that CD8+ T cells play an important role in controlling peripheral tolerance to insulin and may abrogate IIR in a diabetic patient treated with SBI.

Authors

P Naquet, J Ellis, A Kenshole, J W Semple, T L Delovitch

×

Total citations by year

Year: 2024 2007 2005 1998 1997 1991 Total
Citations: 1 1 1 1 1 2 7
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (7)

Title and authors Publication Year
Sulfation pathways in the maintenance of functional beta-cell mass and implications for diabetes
Mueller JW, Thomas P, Dalgaard LT, da Silva Xavier G
Essays in Biochemistry 2024
Immunological Responses to Exogenous Insulin
SE Fineberg, TT Kawabata, D Finco-Kent, RJ Fountaine, GL Finch, AS Krasner
Endocrine reviews 2007
Hypoglycemia and Hyperglycemia Due to Insulin Antibodies against Therapeutic Human Insulin: Treatment with Double Filtration Plasmapheresis and Prednisolone
R Koyama, K Nakanishi, M Kato, S Yamashita, H Kuwahara, H Katori
The American Journal of the Medical Sciences 2005
Use of a Liposome Antigen Delivery System to Alter Immune Responses in Vivo
CM Lutsiak, DL Sosnowski, DS Wishart, GS Kwon, J Samuel
Journal of Pharmaceutical Sciences 1998
INSULINS
MR Burge, DS Schade
Endocrinology & Metabolism Clinics of North America 1997
Altered processing of human insulin by B lymphocytes from an immunologically insulinresistant type I diabetic patient
JW Semple, TL Delovitch
Journal of Autoimmunity 1991
Insulin-dependent (type I) diabetes mellitus
W Rodger
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1991

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 1 patents
9 readers on Mendeley
See more details