We examined the effects of acute exposure to cigarette smoke on the airway responses to substance P in anesthetized guinea pigs and on the activity of airway neutral endopeptidase (NEP). After exposure to air or to cigarette smoke we measured the change in total pulmonary resistance (RL) induced by increasing concentrations of aerosolized substance P in the absence or presence of the NEP inhibitor phosphoramidon. In the absence of phosphramidon the bronchoconstrictor responses to substance P were greater in cigarette smoke-exposed guinea pigs than in air-exposed animals. Phosphoramidon did not further potentiate the responses to substance P in smoke-exposed guinea pigs, whereas it did so in air-exposed animals. In the presence of phosphoramidon, bronchoconstrictor responses to substance P in animals exposed to air or to cigarette smoke were not different. Aerosols of SOD delivered before cigarette smoke exposures dramatically reduced smoke-induced hyperresponsiveness to substance P, whereas heat-inactivated SOD had no effect on smoke-induced hyper-responsiveness to substance P. Cigarette smoke solution inhibited NEP activity from tracheal homogenate in a concentration-dependent fashion, an inhibitory effect that was mostly due to the gas phase of the smoke, but not to nicotine. The mild chemical oxidant N-chlorosuccinimide mimicked the concentration-dependent inhibitory effect of smoke solution on airway NEP activity. We conclude that cigarette smoke causes enhanced airway responsiveness to substance P in vivo by inactivating airway NEP. We suggest that cigarette smoke-induced inhibition of airway NEP is due to effects of free radicals.
D J Dusser, T D Djokic, D B Borson, J A Nadel
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Mediators of Inflammation | 1992 |
Neurogenic Inflammation and Asthma
PJ Barnes |
Journal of Asthma | 1992 |
Sensory, parasympathetic, and sympathetic neural influences in the nasal mucosa
JN Baraniuk |
Journal of Allergy and Clinical Immunology | 1992 |
Mucus secretion and inflammation
JD Lundgren, JN Baraniuk |
Pulmonary Pharmacology | 1992 |
Nedocromil sodium prevents airway hyperreactivity induced by cigarette smoke in anaesthetized guinea-pigs
L Daffonchio, A Hernandez, C Omini |
Pulmonary Pharmacology | 1992 |
Role of peptidases in bradykinin-induced increase in vascular permeability in vivo
T Yong, XP Gao, S Koizumi, JM Conlon, SI Rennard, WG Mayhan, I Rubinstein |
Circulation research | 1992 |
Asthma Treatment
D Olivieri, PJ Barnes, SS Hurd, GC Folco |
1992 | |
Biochemistry of asthma
PJ Barnes |
Trends in Biochemical Sciences | 1991 |
CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung
MA Shipp, GE Tarr, CY Chen, SN Switzer, LB Hersh, H Stein, ME Sunday, EL Reinherz |
Proceedings of the National Academy of Sciences | 1991 |
The upper respiratory tract: mucous membrane irritation
R Bascom |
Environmental Health Perspectives | 1991 |
Cigarette smoke-induced changes in guinea-pig airway responsiveness to histamine and citric acid
JA Karlsson, C Zackrisson, C Sjölin, K Forsberg |
Acta Physiologica Scandinavica | 1991 |
Neuropeptides in the Respiratory Tract: Part II
PJ Barnes, JN Baraniuk, MG Belvisi |
American journal of respiratory and critical care medicine | 1991 |
Endogenous Tachykinins in Antigen-Induced Acute Bronchial Responses of Guinea Pigs
YL Lai |
Experimental Lung Research | 1991 |
Cough in Hot Pepper Workers
P Blanc, D Liu, C Juarez, HA Boushey |
Chest | 1991 |
Hypertonic saline increases vascular permeability in the rat trachea by producing neurogenic inflammation
E Umeno, DM McDonald, JA Nadel |
Journal of Clinical Investigation | 1990 |
Reactive oxygen species and airway inflammation
PJ Barnes |
Free radical biology & medicine | 1990 |
Decreased neutral endopeptidases: Possible role in inflammatory diseases of airways
JA Nadel |
Lung | 1990 |
Effects of epithelium removal on relaxation of airway smooth muscle induced by vasoactive intestinal peptide and electrical field stimulation
SG Farmer, J Togo |
British Journal of Pharmacology | 1990 |
Airway hyperreactivity induced by active cigarette smoke exposure in guinea-pigs: possible role of sensory neuropeptides
L Daffonchio, A Hernandez, L Gallico, C Omini |
Pulmonary Pharmacology | 1990 |
Oxidative injury and the heat shock response
YR Donati, DO Slosman, BS Polla |
Biochemical Pharmacology | 1990 |
Immunohistochemical Localization of Endopeptidase 24.15 in Rat Trachea, Lung Tissue, and Alveolar Macrophages
HS Choi, M Lesser, C Cardozo, M Orlowski |
American journal of respiratory cell and molecular biology | 1990 |
Association of MS Pi Phenotype with Airway Hyperresponsiveness
RG Townley, JG Southard, P Radford, RJ Hopp, AK Bewtra, L Ford |
Chest | 1990 |