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Citations to this article

Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig. Possible role of free radicals.
D J Dusser, … , D B Borson, J A Nadel
D J Dusser, … , D B Borson, J A Nadel
Published September 1, 1989
Citation Information: J Clin Invest. 1989;84(3):900-906. https://doi.org/10.1172/JCI114251.
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Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig. Possible role of free radicals.

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Abstract

We examined the effects of acute exposure to cigarette smoke on the airway responses to substance P in anesthetized guinea pigs and on the activity of airway neutral endopeptidase (NEP). After exposure to air or to cigarette smoke we measured the change in total pulmonary resistance (RL) induced by increasing concentrations of aerosolized substance P in the absence or presence of the NEP inhibitor phosphoramidon. In the absence of phosphramidon the bronchoconstrictor responses to substance P were greater in cigarette smoke-exposed guinea pigs than in air-exposed animals. Phosphoramidon did not further potentiate the responses to substance P in smoke-exposed guinea pigs, whereas it did so in air-exposed animals. In the presence of phosphoramidon, bronchoconstrictor responses to substance P in animals exposed to air or to cigarette smoke were not different. Aerosols of SOD delivered before cigarette smoke exposures dramatically reduced smoke-induced hyperresponsiveness to substance P, whereas heat-inactivated SOD had no effect on smoke-induced hyper-responsiveness to substance P. Cigarette smoke solution inhibited NEP activity from tracheal homogenate in a concentration-dependent fashion, an inhibitory effect that was mostly due to the gas phase of the smoke, but not to nicotine. The mild chemical oxidant N-chlorosuccinimide mimicked the concentration-dependent inhibitory effect of smoke solution on airway NEP activity. We conclude that cigarette smoke causes enhanced airway responsiveness to substance P in vivo by inactivating airway NEP. We suggest that cigarette smoke-induced inhibition of airway NEP is due to effects of free radicals.

Authors

D J Dusser, T D Djokic, D B Borson, J A Nadel

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American journal of respiratory and critical care medicine 1993
Neutral Endopeptidase Activity and Airway Hyperresponsiveness to Neurokinin A in Asthmatic Subjects In Vivo
D Cheung, MC Timmers, AH Zwinderman, JD Hartigh, JH Dijkman, PJ Sterk
American journal of respiratory and critical care medicine 1993
Inhaled A23187 Produces a Preferential Sensitization to Substance P
PW Stengel, AM Bendele, SL Cockerham, SA Silbaugh
American journal of respiratory and critical care medicine 1993
Ozone-induced Increases in Substance P and 8-Epi-Prostaglandin F 2 α in the Airways of Human Subjects
ME Hazbun, R Hamilton, A Holian, WL Eschenbacher
American journal of respiratory cell and molecular biology 1993
Effectiveness of levodropropizine against cigarette smoke-induced airway hyperreactivity: possible mechanism
L Daffonchio, A Hernandez, G Melillo, G Clavenna, C Omini
European Journal of Pharmacology: Environmental Toxicology and Pharmacology 1993
Cigarette Smoking and Health: A Radical View
B Halliwell
The Journal of the Royal Society for the Promotion of Health 1993
Neurogenic inflammation and sensitivity to environmental chemicals
WJ Meggs
Environmental Health Perspectives 1993
Virus-induced airway inflammation and hyperresponsiveness in the guinea-pig is inhibited by levodropropizine
G Folkerts, HJ van der Linde, C Omini, FP Nijkamp
Naunyn-Schmiedeberg's Archives of Pharmacology 1993
Differential Responsiveness to Irritant Mixtures: Possible Mechanisms
R Bascom
Annals of the New York Academy of Sciences 1992
Bronchial responses to substance P after antigen challenge in the guinea-pig: in vivo and in vitro studies
E Boichot, V Lagente, GL Gall, C Carré, JM Mencia-Huerta, P Braquet, A Lockhart, N Frossard
Mediators of Inflammation 1992
Neurogenic Inflammation and Asthma
PJ Barnes
Journal of Asthma 1992
Sensory, parasympathetic, and sympathetic neural influences in the nasal mucosa
JN Baraniuk
Journal of Allergy and Clinical Immunology 1992
Mucus secretion and inflammation
JD Lundgren, JN Baraniuk
Pulmonary Pharmacology 1992
Nedocromil sodium prevents airway hyperreactivity induced by cigarette smoke in anaesthetized guinea-pigs
L Daffonchio, A Hernandez, C Omini
Pulmonary Pharmacology 1992
Role of peptidases in bradykinin-induced increase in vascular permeability in vivo
T Yong, XP Gao, S Koizumi, JM Conlon, SI Rennard, WG Mayhan, I Rubinstein
Circulation research 1992
Asthma Treatment
D Olivieri, PJ Barnes, SS Hurd, GC Folco
1992
Biochemistry of asthma
PJ Barnes
Trends in Biochemical Sciences 1991
CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung
MA Shipp, GE Tarr, CY Chen, SN Switzer, LB Hersh, H Stein, ME Sunday, EL Reinherz
Proceedings of the National Academy of Sciences 1991
The upper respiratory tract: mucous membrane irritation
R Bascom
Environmental Health Perspectives 1991
Cigarette smoke-induced changes in guinea-pig airway responsiveness to histamine and citric acid
JA Karlsson, C Zackrisson, C Sjölin, K Forsberg
Acta Physiologica Scandinavica 1991
Neuropeptides in the Respiratory Tract: Part II
PJ Barnes, JN Baraniuk, MG Belvisi
American journal of respiratory and critical care medicine 1991
Endogenous Tachykinins in Antigen-Induced Acute Bronchial Responses of Guinea Pigs
YL Lai
Experimental Lung Research 1991
Cough in Hot Pepper Workers
P Blanc, D Liu, C Juarez, HA Boushey
Chest 1991
Hypertonic saline increases vascular permeability in the rat trachea by producing neurogenic inflammation
E Umeno, DM McDonald, JA Nadel
Journal of Clinical Investigation 1990
Reactive oxygen species and airway inflammation
PJ Barnes
Free radical biology & medicine 1990
Decreased neutral endopeptidases: Possible role in inflammatory diseases of airways
JA Nadel
Lung 1990
Effects of epithelium removal on relaxation of airway smooth muscle induced by vasoactive intestinal peptide and electrical field stimulation
SG Farmer, J Togo
British Journal of Pharmacology 1990
Airway hyperreactivity induced by active cigarette smoke exposure in guinea-pigs: possible role of sensory neuropeptides
L Daffonchio, A Hernandez, L Gallico, C Omini
Pulmonary Pharmacology 1990
Oxidative injury and the heat shock response
YR Donati, DO Slosman, BS Polla
Biochemical Pharmacology 1990
Immunohistochemical Localization of Endopeptidase 24.15 in Rat Trachea, Lung Tissue, and Alveolar Macrophages
HS Choi, M Lesser, C Cardozo, M Orlowski
American journal of respiratory cell and molecular biology 1990
Association of MS Pi Phenotype with Airway Hyperresponsiveness
RG Townley, JG Southard, P Radford, RJ Hopp, AK Bewtra, L Ford
Chest 1990

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