Citations to this article

Idiotypic sensitization in utero of children born to mothers with schistosomiasis or Chagas' disease.
S M Eloi-Santos, … , D G Colley, R Correa-Oliveira
S M Eloi-Santos, … , D G Colley, R Correa-Oliveira
Published September 1, 1989
Citation Information: J Clin Invest. 1989;84(3):1028-1031. https://doi.org/10.1172/JCI114225.
View: Text | PDF
Research Article Article has an altmetric score of 3

Idiotypic sensitization in utero of children born to mothers with schistosomiasis or Chagas' disease.

Abstract

Cord blood mononuclear cells (CBMC) of neonates born of mothers with Chagas' disease or schistosomiasis exhibited strong proliferative responses against idiotypes expressed on antibodies with specificity for Trypanosoma cruzi or Schistosoma mansoni antigens, respectively. These immunoaffinity-purified preparations were stimulatory if they were prepared from pools of patients' sera or from the mother's own serum, taken early during her pregnancy. These CBMC did not respond to normal immunoglobulin, and CBMC of neonates born of uninfected mothers did not respond to antibodies against either T. cruzi or S. mansoni, or normal immunoglobulin preparations. We propose that in utero exposure of a fetus to some idiotypes expressed on placentally transferred antibodies induces anti-Id T lymphocyte sensitization, which we detect as a proliferative response by CBMC exposed to immunoaffinity-purified antibodies expressing the relevant idiotypes. This is the first experimental evidence that children born of mothers with chronic infections undergo natural in utero idiotypic manipulations and are born possessing cellular anti-Id reactivity.

Authors

S M Eloi-Santos, E Novato-Silva, V M Maselli, G Gazzinelli, D G Colley, R Correa-Oliveira

×

Total citations by year

Year: 2021 2020 2016 2015 2014 2013 2012 2011 2010 2009 2008 2006 2005 2004 2002 2001 2000 1999 1997 1996 1995 1994 1993 1992 1991 1990 Total
Citations: 1 1 1 3 3 1 1 3 2 1 3 1 2 3 2 1 2 5 2 1 1 3 2 3 1 1 50
Citation information

Citations to this article (50)

Title and authors Publication Year
Schistosomes in the Lung: Immunobiology and Opportunity
EL Houlder, AH Costain, PC Cook, AS MacDonald 		Frontiers in immunology 2021
Maternal Latent Mycobacterium tuberculosis Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda
L Lubyayi, PA Mawa, G Nabakooza, M Nakibuule, JV Tushabe, J Serubanja, D Aibo, H Akurut, J Tumusiime, M Hasso-Agopsowicz, P Kaleebu, J Levin, HM Dockrell, S Smith, EL Webb, AM Elliott, S Cose 		Frontiers in immunology 2020
Salivary IgA against sporozoite-specific embryogenesis-related protein (TgERP) in the study of horizontally transmitted toxoplasmosis via T. gondii oocysts in endemic settings
BM Mangiavacchi, FP Vieira, LM Bahia-Oliveira, D HILL 		Epidemiology and Infection 2016
Sm29, but Not Sm22.6 Retains its Ability to Induce a Protective Immune Response in Mice Previously Exposed to a Schistosoma mansoni Infection
CC Alves, N Araujo, VC Santos, FB Couto, NR Assis, SB Morais, SC Oliveira, CT Fonseca, DJ Diemert 		PLoS neglected tropical diseases 2015
Congenital Chagas disease as an ecological model of interactions between Trypanosoma cruzi parasites, pregnant women, placenta and fetuses
Y Carlier, C Truyens 		Acta Tropica 2015
Sex and Gender Differences in Infection and Treatments for Infectious Diseases
SL Klein, CW Roberts 		2015
Human schistosomiasis
DG Colley, AL Bustinduy, WE Secor, CH King 		The Lancet 2014
Pregnancy and helminth infections
H Mpairwe, R Tweyongyere, A Elliott 		Parasite Immunology 2014
Immunology of human schistosomiasis
DG Colley, WE Secor 		Parasite Immunology 2014
The development of TH2 responses from infancy to 4 years of age and atopic sensitization in areas endemic for helminth infections
Y Djuardi, T Supali, H Wibowo, YC Kruize, SA Versteeg, R Ree, E Sartono, M Yazdanbakhsh 		Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2013
Uninfected but not unaffected: chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections
N Dauby, T Goetghebuer, TR Kollmann, J Levy, A Marchant 		The Lancet Infectious Diseases 2012
Advances in Parasitology
H Huang 		Chagas Disease, Part A 2011
Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial
R Tweyongyere, PA Mawa, M Kihembo, FM Jones, EL Webb, S Cose, DW Dunne, BJ Vennervald, AM Elliott 		BMC Infectious Diseases 2011
The Immune Response to Schistosome Antigens in Formerly Infected Travelers
M Mos, JW Geerts, LG Visser, M Yazdanbakhsh, D Soonawala 		The American journal of tropical medicine and hygiene 2011
Acquired immune heterogeneity and its sources in human helminth infection
CD Bourke, RM Maizels, F Mutapi 		Parasitology 2010
Maternal–Fetal Transmission of Trypanosoma cruzi
Y Carlier, C Truyens 		American Trypanosomiasis 2010
Sex Hormones and Immunity to Infection
SL Klein, C Roberts 		2009
Human schistosomiasis mansoni: Immune responses during acute and chronic phases of the infection
IR Caldas, AC Campi-Azevedo, LF Oliveira, AM Silveira, RC Oliveira, G Gazzinelli 		Acta Tropica 2008
Immuno-epidemiology of Schistosoma mansoni infections in endemic populations co-infected with soil-transmitted helminths: Present knowledge, challenges, and the need for further studies
SM Geiger 		Acta Tropica 2008
Urban transmission of Chagas disease in Cochabamba, Bolivia
N Medrano-Mercado, R Ugarte-Fernandez, V Butrón, S Uber-Busek, HL Guerra, TC de Araújo-Jorge, R Correa-Oliveira 		Memórias do Instituto Oswaldo Cruz 2008
Susceptibility of neonate mice born to Schistosoma mansoni-infected and noninfected mothers to subsequent S. mansoni infection
AM Attallah, AT Abbas, MI Dessouky, HM El-emshaty, HM Elsheikha 		Parasitology Research 2006
Studies on Plasmodium falciparum isotypic antibodies and numbers of IL-4 and IFN-γ secreting cells in paired maternal cord blood from South West Cameroon
EA Achidi, JK Anchang, JT Minang, MJ Ahmadou, M Troye-Blomberg 		International Journal of Infectious Diseases 2005
Mucosal Immunology
WR Brown 		Mucosal Immunology 2005
Intestinal worms and human allergy
PJ Cooper 		Parasite Immunology 2004
The effect of colostrum on pigs pre-natally or post-natally exposed to Schistosoma japonicum
ME Techau, MV Johansen, P Lind, N Ornbjerg 		Parasitology 2004
The Potential Impact of Early Exposures to Geohelminth Infections on the Development of Atopy
PJ Cooper 		Clinical Reviews in Allergy & Immunology 2004
Anti-filarial and total lgG4 and IgE antibody levels are correlated in mothers and their offspring
AJ Terhell, S Wahyuni, A Pryce, JW Koot, K Abadi, M Yazdanbakhsh 		Transactions of the Royal Society of Tropical Medicine and Hygiene 2002
Experimental models of Schistosoma mansoni infection
AW Cheever, JA Lenzi, HL Lenzi, ZA Andrade 		Memórias do Instituto Oswaldo Cruz 2002
Prenatal Exposure, Maternal Sensitization, and Sensitization In Utero To Indoor Allergens in an Inner-City Cohort
RL Miller, GL Chew, CA Bell, SA Biedermann, M Aggarwal, PL Kinney, WY Tsai, RM Whyatt, FP Perera, JG Ford 		American journal of respiratory and critical care medicine 2001
Immunopathology of schistosomiasis: a cautionary tale of mice and men
PG Fallon 		Immunology Today 2000
Natural versus Drug-induced Resistance in Schistosoma mansoni Infection
R Corrêa-Oliveira, IR Caldas, G Gazzinelli 		Parasitology Today 2000
In utero sensitization in Chagas' disease leads to altered lymphocyte phenotypic patterns in the newborn cord blood mononuclear cells
SF Neves, S Eloi-Santos, R Ramos, S Rigueirinho, G Gazzinelli, R Correa-Oliveira 		Parasite Immunology 1999
Neonatal idiotypic exposure alters subsequent cytokine, pathology, and survival patterns in experimental Schistosoma mansoni infections
MA Montesano, DG Colley, S Eloi-Santos, GL Freeman, WE Secor 		Journal of Experimental Medicine 1999
Neonatal Idiotypic Exposure Alters Subsequent Cytokine, Pathology, and Survival Patterns in Experimental Schistosoma mansoni Infections
MA Montesano, DG Colley, S Eloi-Santos, GL Freeman, WE Secor 		Journal of Experimental Medicine 1999
Infection-stimulated or perinatally initiated idiotypic interactions can direct differential morbidity and mortality in schistosomiasis
DG Colley, MA Montesano, GL Freeman, WE Secor 		Microbes and Infection 1999
Development of Antibody Isotype Responses to Schistosoma mansoni in an Immunologically Naive Immigrant Population: Influence of Infection Duration, Infection Intensity, and Host Age
SH Kaufmann, CW Naus, G Kimani, JH Ouma, AJ Fulford, M Webster, GJ van Dam, AM Deelder, AE Butterworth, DW Dunne 		Infection and immunity 1999
In utero exposure to helminth and mycobacterial antigens generates cytokine responses similar to that observed in adults
I Malhotra, J Ouma, A Wamachi, J Kioko, P Mungai, A Omollo, L Elson, D Koech, JW Kazura, CL King 		Journal of Clinical Investigation 1997
Haemophilus influenzae type b-specific antibody in infants after maternal immunization
JA Englund, WP Glezen, C Thompson, R Anwaruddin, CS Turner, GR Siber 		The Pediatric Infectious Disease Journal 1997
In utero exposure to Onchocerca volvulus: relationship to subsequent infection intensity and cellular immune responsiveness
LH Elson, A Days, M Calvopiña, W Paredes, E Araujo, RH Guderian, JE Bradley, TB Nutman 		Infection and immunity 1996
Influence of maternal infection on offspring resistance towards parasites
Y Carlier, C Truyens 		Parasitology Today 1995
Maternal Immunization to Prevent Infectious Diseases in the Neonate or Infant
RA Insel, M Amstey, K Woodin, M Pichichero 		International Journal of Technology Assessment in Health Care 1994
Long-term effect of prenatal exposure to maternal microfilaraemia on immune responsiveness to filarial parasite antigens
C Steel, JS McCarthy, E Ottesen, A Guinea 		The Lancet 1994
Parasitic Infections and the Immune System
F Kierszenbaum, MB Sztein 		Parasitic Infections and the Immune System 1994
Trypanosoma cruzi infection in women
L Brabin 		Parasitology Today 1993
Molecular Biology and its Application to Medical Mycology
B Maresca, GS Kobayashi, H Yamaguchi 		1993
Immune Responses During Human Schistosomiasis Mansoni. XVIII. Immunologic Status of Pregnant Women and Their Neonates
E Novato-Silva, G Gazzinelli, DG Colley 		Scandinavian Journal of Immunology 1992
Analysis of anti-keyhole limpet haemocyanin antibody in Brazilians supports its use for the diagnosis of acute schistosomiasis mansoni
CF Alves-Brito, AJ Simpson, LM Bahia-Oliveira, AL Rabello, RS Rocha, JR Lambertucci, G Gazzinelli, N Katz, R Correa-Oliveira 		Transactions of the Royal Society of Tropical Medicine and Hygiene 1992
Human immune responses during schistosomiasis mansoni
G Gazzinelli, DG Colley 		Revista da Sociedade Brasileira de Medicina Tropical 1992
Immunological aspects of the morbidity of human Chagas' disease
G Gazzinelli, Z Brener 		Research in Immunology 1991
Two modes of idiotypic stimulation of T lymphocytes from patients with Chagas' disease: Correlations with clinical forms of infection
RT Gazzinelli, G Gazzinelli, JR Cançado, JE Cardoso, Z Brener, DG Colley 		Research in Immunology 1990

Advertisement