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Citations to this article

Acquired congenital heart block. Pattern of maternal antibody response to biochemically defined antigens of the SSA/Ro-SSB/La system in neonatal lupus.
J P Buyon, … , E M Tan, R Winchester
J P Buyon, … , E M Tan, R Winchester
Published August 1, 1989
Citation Information: J Clin Invest. 1989;84(2):627-634. https://doi.org/10.1172/JCI114208.
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Research Article Article has an altmetric score of 6

Acquired congenital heart block. Pattern of maternal antibody response to biochemically defined antigens of the SSA/Ro-SSB/La system in neonatal lupus.

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Abstract

The molecular basis of autoantibody reactivity with components of the SSA/Ro-SSB/La particle exhibited by sera of mothers of infants with severe and permanent manifestations of neonatal lupus (NLE) was investigated using immunoblotting and immunoprecipitation. The characteristics of NLE that were studied included congenital complete heart block (CCHB), second degree heart block, and hepatic fibrosis. Antibodies specific for one or more components of the SSA/Ro-SSB/La particle were found in sera from all 20 mothers of permanently affected infants. However, no antibody specific for a single peptide of this particle was common to all sera. Using tissue extracts from a human cell substrate, 80% of these sera had antibodies to one or more components of the SSA/Ro particle demonstrable by immunoblotting. The predominant antibody response in the NLE group was to the newly recognized 52-kD SSA/Ro peptide component. In contrast, antibodies to the 60-kD SSA/Ro component although present, were the least represented and not significantly increased in frequency among mothers of these infants, compared with a group of 31 mothers with autoimmune diseases such as systemic lupus erythromatosus (SLE) but who had healthy offspring. Antibodies directed to the 48-kD SSB/La antigen were demonstrated in 90% of the NLE mothers often accompanying antibodies against the 52-kD SSA/Ro component. The combination of antibodies to 48- and 52-kD structures was significantly increased in the NLE group, with an odds ratio of 35. The type of cell or tissue substrate was shown to influence detectability of antibodies. The 52-kD SSA/Ro peptide and the 48-kD SSB/La peptide were abundant in cardiac tissues from fetuses aged 18-24 wk, further supporting the possible relevance of these peptides to heart block.

Authors

J P Buyon, E Ben-Chetrit, S Karp, R A Roubey, L Pompeo, W H Reeves, E M Tan, R Winchester

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Year: 2022 2020 2019 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2003 2002 2001 2000 1999 1998 1997 1995 1994 1993 1992 1991 1990 1987 Total
Citations: 2 1 2 3 1 3 3 2 5 4 5 1 4 3 2 2 2 3 4 6 7 6 8 13 12 17 18 10 11 1 161
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Citations to this article in year 2012 (5)

Title and authors Publication Year
Umbilical cord blood levels of maternal antibodies reactive with p200 and full-length Ro 52 in the assessment of risk for cardiac manifestations of neonatal lupus
JH Reed, RM Clancy, KH Lee, A Saxena, PM Izmirly, JP Buyon
Arthritis Care & Research 2012
Clinical and pathological roles of Ro/SSA autoantibody system
R Yoshimi, A Ueda, K Ozato, Y Ishigatsubo
Clinical & developmental immunology 2012
Evaluation of Transplacental Treatment for Fetal Congenital Bradyarrhythmia
T Miyoshi, Y Maeno, H Sago, N Inamura, S Yasukohchi, M Kawataki, H Horigome, H Yoda, M Taketazu, M Shozu, M Nii, H Kato, S Hayashi, A Hagiwara, A Omoto, W Shimizu, I Shiraishi, H Sakaguchi, K Nishimura, K Ueda, S Katsuragi, T Ikeda
Circulation Journal 2012
Neonatal autoimmune diseases: A critical review
C Chang
Journal of Autoimmunity 2012
Maternal autoantibody levels in congenital heart block and potential prophylaxis with antiinflammatory agents
RD Tunks, ME Clowse, SG Miller, LR Brancazio, PC Barker
American Journal of Obstetrics and Gynecology 2012

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