TR- mutant rats have an autosomal recessive mutation that is expressed as a severely impaired hepatobiliary secretion of organic anions like bilirubin-(di)glucuronide and dibromosulphthalein (DBSP). In this paper, the hepatobiliary transport of glutathione and a glutathione conjugate was studied in normal Wistar rats and TR- rats. It was shown that glutathione is virtually absent from the bile of TR- rats. In the isolated, perfused liver the secretion of glutathione and the glutathione conjugate, dinitrophenyl-glutathione (GS-DNP), from hepatocyte to bile is severely impaired, whereas the sinusoidal secretion from liver to blood is not affected. The secretion of GS-DNP was also studied in isolated hepatocytes. The secretion of GS-DNP from cells isolated from TR- rat liver was significantly slower than from normal hepatocytes. Efflux of GS-DNP was a saturable process with respect to intracellular GS-DNP concentration: Vmax and Km for efflux from TR- cells was 498 nmol/min.g dry wt and 3.3 mM, respectively, as compared with 1514 nmol/min.g dry wt and 0.92 mM in normal hepatocytes. These results suggest that the canalicular transport system for glutathione and glutathione conjugates is severely impaired in TR- rats, whereas sinusoidal efflux is unaffected. Because the defect also comes to expression in isolated hepatocytes, efflux of GS-DNP from normal hepatocytes must predominantly be mediated by the canalicular transport mechanism, which is deficient in TR- rats.
R P Elferink, R Ottenhoff, W Liefting, J de Haan, P L Jansen
Title and authors | Publication | Year |
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X Niu, IA de Graaf, D de Vegte, M Langelaar-Makkinje, S Sekine, GM Groothuis |
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L Qiu, J Finley, M Taimi, MD Aleo, C Strock, J Gilbert, S Qin, Y Will |
Applied In Vitro Toxicology | 2015 |
ABC Transporters - 40 Years on
AM George |
ABC Transporters - 40 Years on | 2015 |
Modulation of biotransformation systems and ABC transporters by benznidazole in rats
VG Perdomo, JP Rigalli, SS Villanueva, ML Ruiz, MG Luquita, CG Echenique, VA Catania |
Antimicrobial agents and chemotherapy | 2013 |
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ND Pfeifer, AS Bridges, BC Ferslew, RN Hardwick, KL Brouwer |
The Journal of pharmacology and experimental therapeutics | 2013 |
EASL Recognition Awardee 2012
M Trauner |
Journal of Hepatology | 2012 |
Fibroblast growth factor 21 is induced by endoplasmic reticulum stress
FG Schaap, AE Kremer, WH Lamers, PL Jansen, IC Gaemers |
Biochimie | 2012 |
Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor
JP Rigalli, VG Perdomo, MG Luquita, SS Villanueva, A Arias, D Theile, J Weiss, AD Mottino, ML Ruiz, VA Catania, TG Geary |
PLoS neglected tropical diseases | 2012 |
Cellular Localization and Biochemical Analysis of Mammalian CDC50A, a Glycosylated β-subunit for P4 ATPases
DE Folmer, KS Mok, SW de Wee, S Duijst, JK Hiralall, J Seppen, RP Elferink, CC Paulusma |
Journal of Histochemistry & Cytochemistry | 2012 |
Bilirubin Metabolism and Jaundice
AW Wolkoff, PD Berk |
Schiff s Diseases of the Liver Schiff/Schiff s Diseases of the Liver | 2011 |
Schiff's Diseases of the Liver: Schiff/Schiff's Diseases of the Liver
H Malhi, GJ Gores |
Schiff's Diseases of the Liver: Schiff/Schiff's Diseases of the Liver | 2011 |
Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation
CD Klaassen, LM Aleksunes |
Pharmacological reviews | 2010 |
Biliary secretion of S-nitrosoglutathione is involved in the hypercholeresis induced by ursodeoxycholic acid in the normal rat
CM Rodríguez-Ortigosa, JM Banales, I Olivas, I Uriarte, JJ Marín, FJ Corrales, JF Medina, J Prieto |
Hepatology | 2010 |
ABCC2/Abcc2: a multispecific transporter with dominant excretory functions
K Jemnitz, K Heredi-Szabo, J Janossy, E Ioja, L Vereczkey, P Krajcsi |
Drug Metabolism Reviews | 2010 |
Impact of Acute Streptozotocin-Induced Diabetes on ABC Transporter Expression in Rats
GJ Anger, L Magomedova, M Piquette-Miller |
Chemistry & Biodiversity | 2009 |
Transporters as Drug Carriers: Structure, Function, Substrates
G Ecker, P Chiba |
Transporters as Drug Carriers: Structure, Function, Substrates | 2009 |
Mechanism of trifluralin-induced thyroid tumors in rats
SA Saghir, GD Charles, MJ Bartels, LH Kan, MD Dryzga, KA Brzak, AJ Clark |
Toxicology Letters | 2008 |
ABCC2/Abcc2 Transport Property in Different Species and its Modulation by Heterogeneous Factors
K ITO |
Drug Metabolism and Pharmacokinetics | 2008 |
MRP class of human ATP binding cassette (ABC) transporters: historical background and new research directions
Y Toyoda, Y Hagiya, T Adachi, K Hoshijima, MT Kuo, T Ishikawa |
Xenobiotica | 2008 |
MRP2 haplotypes confer differential susceptibility to toxic liver injury
JH Choi, BM Ahn, J Yi, JH Lee, JH Lee, SW Nam, CY Chon, KH Han, SH Ahn, IJ Jang, JY Cho, Y Suh, MO Cho, JE Lee, KH Kim, MG Lee |
Pharmacogenetics and Genomics | 2007 |
Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor-E2–related factor-2 transcriptional pathway
JM Maher, MZ Dieter, LM Aleksunes, AL Slitt, G Guo, Y Tanaka, GL Scheffer, JY Chan, JE Manautou, Y Chen, TP Dalton, M Yamamoto, CD Klaassen |
Hepatology | 2007 |
Multidrug resistance associated protein 2 mediates transport of prostaglandin E2
DR de Waart, CC Paulusma, C Kunne, RP Elferink |
Liver International | 2006 |
Integration of hepatic drug transporters and phase II metabolizing enzymes: Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites
MJ Zamek-Gliszczynski, KA Hoffmaster, K Nezasa, MN Tallman, KL Brouwer |
European Journal of Pharmaceutical Sciences | 2006 |
Hyperbaric oxygen stimulates cell proliferation and normalizes multidrug resistance protein-2 protein localization in primary rat hepatocytes
T Mizuguchi, H Oshima, H Imaizumi, H Kohara, M Kawamoto, T Nobuoka, H Kawasaki, K Harada, Y Masuda, Y Kikkawa, T Mitaka, Y Asai, K Hirata |
Wound Repair and Regeneration | 2005 |
Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins
N Ballatori, CL Hammond, JB Cunningham, SM Krance, R Marchan |
Toxicology and Applied Pharmacology | 2005 |
Mechanisms involved in spironolactone-induced choleresis in the rat
ML Ruiz, SS Villanueva, MG Luquita, EJ Sánchez-Pozzi, FA Crocenzi, JM Pellegrino, JE Ochoa, M Vore, AD Mottino, VA Catania |
Biochemical Pharmacology | 2005 |
Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR− rats
C Chen, AL Slitt, MZ Dieter, Y Tanaka, GL Scheffer, CD Klaassen |
Biochemical Pharmacology | 2005 |
Transport deficient (TR−) hyperbilirubinemic rats are resistant to acetaminophen hepatotoxicity
VM Silva, MS Thibodeau, C Chen, JE Manautou |
Biochemical Pharmacology | 2005 |
Function and Regulation of Multidrug Resistance Proteins (MRPs) in the Renal Elimination of Organic Anions
FM van de Water, R Masereeuw, FG Russel |
Drug Metabolism Reviews | 2005 |
PREVENTION OF MRP2 ACTIVITY IMPAIRMENT IN ETHINYLESTRADIOL-INDUCED CHOLESTASIS BY URSODEOXYCHOLATE IN THE RAT
FA Crocenzi, V D'Andrea, VA Catania, MG Luquita, JM Pellegrino, JE Ochoa, AD Mottino, EJ Pozzi |
Drug Metabolism and Disposition | 2005 |
Involvement of Mrp2 in Hepatic and Intestinal Disposition of Dinitrophenyl-S-glutathione in Partially Hepatectomized Rats
SS Villanueva, ML Ruiz, MG Luquita, EJ Pozzi, VA Catania, AD Mottino |
Toxicological Sciences | 2004 |
Abolition of Valproate-Derived Choleresis in the Mrp2 Transporter-Deficient Rat
AW Wright, RG Dickinson |
The Journal of pharmacology and experimental therapeutics | 2004 |
The MRP family of drug efflux pumps
GD Kruh, MG Belinsky |
Oncogene | 2003 |
Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells
H Lou, M Ookhtens, A Stolz, N Kaplowitz |
AJP Gastrointestinal and Liver Physiology | 2003 |
HEPATOBILIARY EXCRETION OF ACETAMINOPHEN GLUTATHIONE CONJUGATE AND ITS DERIVATIVES IN TRANSPORT-DEFICIENT (TR - ) HYPERBILIRUBINEMIC RATS
C Chen, GE Hennig, JE Manautou |
Drug Metabolism and Disposition | 2003 |
Canalicular bile formation: beyond single transporter functions
PJ Meier |
Journal of Hepatology | 2002 |
Contribution of mrp2 in alterations of canalicular bile formation by the endothelin antagonist bosentan
L Fouassier, N Kinnman, G Lefèvre, E Lasnier, C Rey, R Poupon, RP Elferink, C Housset |
Journal of Hepatology | 2002 |
Membrane Transporters as Drug Targets
GL Amidon, W Sadée |
2002 | |
Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green
VM Silva, C Chen, GE Hennig, HE Whiteley, JE Manautou |
Food and Chemical Toxicology | 2001 |
Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes
CL Hammond, TK Lee, N Ballatori |
Journal of Hepatology | 2001 |
MRP subfamily transporters and resistance to anticancer agents
G D Kruh, H Zeng, P A Rea, G Liu, Z S Chen, K Lee, M G Belinsky |
Journal of Bioenergetics and Biomembranes | 2001 |
Electron-microscopic demonstration of multidrug resistance protein 2 (Mrp2) retrieval from the canalicular membrane in response to hyperosmolarity and lipopolysaccharide
F Dombrowski, R Kubitz, A Chittattu, M Wettstein, N Saha, D Häussinger |
Biochemical Journal | 2000 |
Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver
CC Paulusma, MJ Kothe, CT Bakker, PJ Bosma, I Bokhoven, J Marle, U Bolder, GN Tytgat, RP Elferink |
Hepatology | 2000 |
The MRP2/cMOAT Transporter and Arsenic-Glutathione Complex Formation Are Required for Biliary Excretion of Arsenic
SV Kala, MW Neely, G Kala, CI Prater, DW Atwood, JS Rice, MW Lieberman |
The Journal of biological chemistry | 2000 |
Mrp2 is essential for estradiol-17β(β-D -glucuronide)–induced cholestasis in rats
L Huang, JW Smit, DK Meijer, M Vore |
Hepatology | 2000 |
Oxidative Stress as a Cause of Biliary Lithiasis: New Possibilities for Medical Therapy of Stones or a False Alarm?
RD Soloway, SA Weinman |
Hepatology | 2000 |
Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione
CC Paulusma, MA van Geer, R Evers, M Heijn, R Ottenhoff, P Borst, RP Elferink |
Biochemical Journal | 1999 |
Induction of the multispecific organic anion transporter (cMoat/mrp2) gene and biliary glutathione secretion by the herbicide 2,4,5-trichlorophenoxyacetic acid in the mouse liver
AM Wielandt, V Vollrath, M Manzano, S Miranda, L Accatino, J Chianale |
Biochemical Journal | 1999 |
Dexamethasone- and osmolarity-dependent expression of the multidrug-resistance protein 2 in cultured rat hepatocytes
R Kubitz, U Warskulat, M Schmitt, D Häussinger |
Biochemical Journal | 1999 |
DRUG-INDUCED CHOLESTASIS
FR Simon |
Clinics in Liver Disease | 1998 |
Molecular mechanisms of cholestasis: causes and consequences of impaired bile formation
N R Koopen, M Müller, R J Vonk, P Zimniak, F Kuipers |
Biochimica et Biophysica Acta | 1998 |
Impaired activity of the bile canalicular organic anion transporter (Mrp2/cmoat) is not the main cause of ethinylestradiol-induced cholestasis in the rat: Impaired Activity of the Bile Canalicular Organic Anion Transporter (Mrp2/cmoat) Is Not the Main Cause of Ethinylestradiol-Induced Cholestasis in the
NR Koopen, H Wolters, R Havinga, RJ Vonk, PL Jansen, M Müller, F Kuipers |
Hepatology | 1998 |
ATP-dependent Transport of Reduced Glutathione on YCF1, the Yeast Orthologue of Mammalian Multidrug Resistance Associated Proteins
JF Rebbeor, GC Connolly, ME Dumont, N Ballatori |
The Journal of biological chemistry | 1998 |
CHOLESTASIS AND ALTERATIONS OF GLUTATHIONE METABOLISM INDUCED BY TACROLIMUS (FK506) IN THE RAT1:
S Sanchez-Campos, R Lopez-Acebo, P Gonzalez, JM Culebras, MJ Tuon, J Gonzalez-Gallego |
Transplantation | 1998 |
Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets
H Roelofsen, CJ Soroka, D Keppler, JL Boyer |
Journal of cell science | 1998 |
Differential Interaction of Bile Acids from Patients with Inborn Errors of Bile Acid Synthesis with Hepatocellular Bile Acid Transporters
B Stieger, J Zhang, B O'Neill, J Sjovall, PJ Meier |
European Journal of Biochemistry | 1997 |
Regulation of organic anion transport in the liver
H Roelofsen, M Müller, PL Jansen |
The Yale journal of biology and medicine | 1997 |
Hepatic glutathione and glutathione S-conjugate transport mechanisms
TK Lee, L Li, N Ballatori |
The Yale journal of biology and medicine | 1997 |
Multiple Routes and Regulation by Tyrosine Phosphorylation Characterize the ATP-Dependent Transport of 2,4-DinitrophenylS-Glutathione in Inside-Out Vesicles from Human Erythrocytes
M Saxena, GB Henderson |
Archives of Biochemistry and Biophysics | 1997 |
Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment
ND Hadjiliadis |
1997 | |
Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells
R Evers, GJ Zaman, L Deemter, H Jansen, J Calafat, LC Oomen, RP Elferink, P Borst, AH Schinkel |
Journal of Clinical Investigation | 1996 |
Review Article: New insights into the mechanisms of hepatic transport and bile secretion
S Erlinger |
Journal of Gastroenterology and Hepatology | 1996 |
Bilirubin glucuronidation by intact Gunn rat fibroblasts expressing bilirubin UDP-glucuronosyltransferase
J Seppen, K Tada, S Hellwig, CT Bakker, VR Prasad, NR Chowdhury, JR Chowdhury, PJ Bosma, RP Elferink |
Biochemical Journal | 1996 |
ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump
I Leier, G Jedlitschky, U Buchholz, M Center, SP Cole, RG Deeley, D Keppler |
Biochemical Journal | 1996 |
Effects of ursodeoxycholate and its conjugates on biliary glutathione excretion in rats
H Takikawa, N Sano, M Yamanaka |
Digestive Diseases and Sciences | 1996 |
Effect of diethylmaleate on bile secretion and ultrastructural appearance of hepatocytes in normal rats and mutant rats with defective organic anion secretion
M Dumont, C D'Hont, G Feldmann, E Rogier, A Moreau, PL Jansen, S Erlinger |
Liver | 1996 |
Bile secretion of cadmium, silver, zinc and copper in the rat. Involvement of various transport systems
M Dijkstra, R Havinga, RJ Vonk, F Kuipers |
Life Sciences | 1996 |
Inhibition of glutathione S-transferase activity in human melanoma cells by α,β-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal
ML van Iersel, JP Ploemen, I Struik, C Amersfoort, AE Keyzer, JG Schefferlie, PJ van Bladeren |
Chemico-Biological Interactions | 1996 |
The function of the multidrug resistance proteins (MRP and cMRP) in drug conjugate transport and hepatobiliary excretion
D Keppler, I Leier, G Jedlitschky, R Mayer, M Büchler |
Advances in Enzyme Regulation | 1996 |
ATP-dependent 17-Estradiol 17-(-D-Glucuronide) Transport by Multidrug Resistance Protein (MRP): INHIBITION BY CHOLESTATIC STEROIDS
DW Loe, KC Almquist, SP Cole, RG Deeley |
The Journal of biological chemistry | 1996 |
Molecular Biology of Membrane Transport Disorders
SG Schultz, TE Andreoli, AM Brown, DM Fambrough, JF Hoffman, MJ Welsh |
1996 | |
Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics
M Yamazaki, H Suzuki, Y Sugiyama |
Pharmaceutical Research | 1996 |
The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I
JD Hayes, DJ Pulford |
Critical Reviews in Biochemistry and Molecular Biology | 1995 |
The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part II
JD Hayes, DJ Pulford |
Critical Reviews in Biochemistry and Molecular Biology | 1995 |
Carrier-mediated uptake and excretion of bromosulfophthalein-glutathione in perfused rat liver: A multiple indicator dilution study
WP Geng, AJ Schwab, CA Goresky, KS Pang |
Hepatology | 1995 |
New insights into the mechanism of bile acid—induced biliary lipid secretion
HJ Verkade, RJ Vonk, F Kuipers |
Hepatology | 1995 |
Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes
R Mayer, J Kartenbeck, M Büchler, G Jedlitschky, I Leier, D Keppler |
The Journal of Cell Biology | 1995 |
Hepatobiliary transport of hepatic 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors conjugated with bile acids
E Petzinger, L Nickau, JA Horz, S Schulz, G Wess, A Enhsen, E Falk, KH Baringhaus, H Glombik, A Hoffmann, S Müllner, G Neckermann, W Kramer |
Hepatology | 1995 |
Impaired biliary excretion and whole body elimination of methylmercury in rats with a congenital defect in biliary glutathione excretion
N Ballatori, Z Gatmaitan, AT Truong |
Hepatology | 1995 |
Redistribution of canalicular organic anion transport activity in isolated and cultured rat hepatocytes
H Roelofsen, CT Bakker, B Schoemaker, M Heijn, PL Jansen, RP Elferink |
Hepatology | 1995 |
Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport
RP Elferink, DK Meijer, F Kuipers, PL Jansen, AK Groen, GM Groothuis |
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes | 1995 |
Dynamic aspects of glutathione metabolism in obstructive jaundice
M Hirota, K Sugi, M Inoue |
Journal of Gastroenterology | 1994 |
The role of the canalicular multispecific organic anion transporter in the disposal of endo-and xenobiotics
RP Elferink, PL Jansen |
Pharmacology & Therapeutics | 1994 |
ATP-dependent transport of organic anions in secretory vesicles of Saccharomyces cerevisiae
MV St-Pierre, S Ruetz, LF Epstein, P Gros, IM Arias |
Proceedings of the National Academy of Sciences | 1994 |
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
M Müller, C Meijer, GJ Zaman, P Borst, RJ Scheper, NH Mulder, EG de Vries, PL Jansen |
Proceedings of the National Academy of Sciences | 1994 |
Bile flow in a mutant Sprague-Dawley rat with defective biliary excretion of glutathione
H Yoshida, K Okano, T Tamano, Y Kuronuma, M Iijima |
Journal of Gastroenterology | 1994 |
Glutathione conjugation and conversion to mercapturic acids can occur as an intrahepatic process
CA Hinchman, N Ballatori |
Journal of Toxicology and Environmental Health | 1994 |
Bile Viscosity in Patients with Biliary Drainage: Effect of Co-Trimoxazole and N- Acetylcysteine and Role in Stent Clogging
PP Coene, AK Groen, PH Davids, M Hardeman, GN Tytgat, K Huibregtse |
Scandinavian Journal of Gastroenterology | 1994 |
Decreased bilirubin transport in the perfused liver of endotoxemic rats
H Roelofsen, CN van der Veere, R Ottenhoff, B Schoemaker, LM Jansen, RP Elferink |
Gastroenterology | 1994 |
Biliary Amino Acid and Glutathione Secretion in Response to Amino Acid Infusion in the Isolated Rat Liver
KE Shattuck, CD Grinnell, DK Rassin |
JPEN. Journal of parenteral and enteral nutrition | 1994 |
New concepts in bilirubin chemistry, transport and metabolism: Report of the second international bilirubin workshop, April 9–11, 1992, trieste, Italy
C Tiribelli, JD Ostrow |
Hepatology | 1993 |
Organic anions exhibit distinct inhibition patterns on the low-Km and high-Km transport of S-(2,4-dinitrophenyl)glutathione through the human erythrocyte membrane
G Bartosz, H Sies, TP Akerboom |
Biochemical Journal | 1993 |
Glutathione-conjugate transport by human colon adenocarcinoma cells (Caco-2 cells)
RP Elferink, CT Bakker, PL Jansen |
Biochemical Journal | 1993 |
The biology of the bile canaliculus, 1993
IM Arias, M Che, Z Gatmaitan, C Leveille, T Nishida, MS Pierre |
Hepatology | 1993 |
ATP-dependent transport systems for organic anions
P Zimniak, YC Awasthi |
Hepatology | 1993 |
Functional integrity of hepatocyte canalicular membrane transport of taurocholate and bilirubin diglucuronide in eisai hyperbilirubinuria rats
Y Adachi, H Kobayashi, M Shouji, M Kitano, Y Okuyama, T Yamamoto |
Life Sciences | 1993 |
Complete elimination of the hepatobiliary mr contrast agent Gd-EOB-DTPA in hepatic dysfunction: An experimental study using transport-deficient, mutant rats
A Muhler, RP Elferink, HJ Weinmann |
MAGMA Magnetic Resonance Materials in Physics, Biology, and Medicine | 1993 |
Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter
RP Elferink, CT Bakker, H Roelofsen, E Middelkoop, R Ottenhoff, M Heijn, PL Jansen |
Hepatology | 1993 |
Cyclosporin, the biology of the bile canaliculus, and cholestasis
IM Arias |
Gastroenterology | 1993 |
Inhibition by cyclosporin A of Adenosine triphosphate-dependent transport from the hepatocyte into bile
M Kadmon, C Klünemann, M Böhme, T Ishikawa, K Gorgas, G Otto, C Herfarth, D Keppler |
Gastroenterology | 1993 |
Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
J J Smit, A H Schinkel, R P Oude Elferink, A K Groen, E Wagenaar, L van Deemter, C A Mol, R Ottenhoff, N M van der Lugt, M A van Roon |
Cell | 1993 |
Relationship between biliary excretion of bilirubin and glutathione disulfide
Y Kuronuma, H Yoshida, M Iijima, T Harada |
Gastroenterologia Japonica | 1993 |
Identification of an anion-transport ATPase that catalyzes glutathione conjugate-dependent ATP hydrolysis in canalicular plasma membranes from normal rats and rats with conjugated hyperbilirubinemia (GY mutant)
P Zimniak, SA Ziller, I Panfil, A Radominska, H Wolters, F Kuipers, R Sharma, M Saxena, MT Moslen, M Vore, R Vonk, YC Awasthi, R Lester |
Archives of Biochemistry and Biophysics | 1992 |
Dinitrophenyl S-glutathione ATPase purified from human muscle catalyzes ATP hydrolysis in the presence of leukotrienes
M Saxena, SS Singhal, S Awasthi, SV Singh, EF Labelle, P Zimniak, YC Awasthi |
Archives of Biochemistry and Biophysics | 1992 |
Determinants in the hepatic uptake of organic anions
C Tiribelli |
Journal of Hepatology | 1992 |
Inhibition of biliary excretion of indocyanine green by the thiol-oxidizing agent, diazenedicarboxylic acid bis[n,n′-dimethylamide]
H Yoshida, M Iijima, Y Kuronuma, T Harada |
Biochemical Pharmacology | 1992 |
ATP-dependent multispecific organic anion transport system in rat erythrocyte membrane vesicles
M Heijn, RP Elferink, PL Jansen |
American journal of physiology. Cell physiology | 1992 |
The relationship between biliary secretion of bilirubin and glutathione in the rat
H Yoshida, Y Kuronuma, M Iijima, T Harada, J Kuhlenkamp, N Kaplowitz |
Gastroenterologia Japonica | 1992 |
Mammalian Amino Acid Transport
MS Kilberg, D Häussinger |
1992 | |
Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats
JC Fernández-Checa, H Takikawa, T Horie, M Ookhtens, N Kaplowitz |
The Journal of biological chemistry | 1992 |
ATP-dependent taurocholate transport by rat liver canalicular membrane vesicles
Y Adachi, H Kobayashi, Y Kurumi, M Shouji, M Kitano, T Yamamoto |
Hepatology | 1991 |
Glutathione metabolism and its role in hepatotoxicity
LD DeLeve, N Kaplowitz |
Pharmacology & Therapeutics | 1991 |
Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant sprague-dawley rat
H Takikawa, N Sano, T Narita, Y Uchida, M Yamanaka, T Horie, T Mikami, O Tagaya |
Hepatology | 1991 |
Rat liver canalicular membrane vesicles contain an ATP-dependent bile acid transport system
T Nishida, Z Gatmaitan, M Che, IM Arias |
Proceedings of the National Academy of Sciences | 1991 |
Inhibition of glutathione-conjugate secretion from isolated hepatocytes by dipolar bile acids and other organic anions
RP Elferink, R Ottenhoff, A Radominska, AF Hofmann, F Kuipers, PL Jansen |
Biochemical Journal | 1991 |
Hepatocanalicular organic-anion transport is regulated by protein kinase C
H Roelofsen, R Ottenhoff, RP Elferink, PL Jansen |
Biochemical Journal | 1991 |
The anionic conjugates of bilirubin and bile acids stimulate ATP hydrolysis by S-(dinitrophenyl)glutathione ATPase of human erythrocyte
SS Singhal, R Sharma, S Gupta, H Ahmad, P Zimniak, A Radominska, R Lester, YC Awasthi |
FEBS Letters | 1991 |
Purification and characterization of an ATPase from human liver which catalyzes ATP hydrolysis in the presence of the conjugates of bilirubin, bile acids and glutathione
YC Awasthi, SS Singhal, S Gupta, H Ahmad, P Zimniak, A Radominska, R Lester, R Sharma |
Biochemical and Biophysical Research Communications | 1991 |
ATP-Dependent transport for glucuronides in canalicular plasma membrane vesicles
K Kobayashi, S Komatsu, T Nishi, H Hara, K Hayashi |
Biochemical and Biophysical Research Communications | 1991 |
New insights into canalicular organic anion secretion
RH Moseley |
Hepatology | 1991 |
Liver Pathology and Alcohol
RR Watson |
1991 | |
ATP-dependent S-(2,4-dinitrophenyl)glutathione transport in canalicular plasma membrane vesicles from rat liver
TP Akerboom, V Narayanaswami, M Kunst, H Sies |
The Journal of biological chemistry | 1991 |
Intrahepatic conversion of a glutathione conjugate to its mercapturic acid. Metabolism of 1-chloro-2,4-dinitrobenzene in isolated perfused rat and guinea pig livers
CA Hinchman, H Matsumoto, TW Simmons, N Ballatori |
The Journal of biological chemistry | 1991 |
Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia
T Kitamura, P Jansen, C Hardenbrook, Y Kamimoto, Z Gatmaitan, IM Arias |
Proceedings of the National Academy of Sciences | 1990 |
The uncoupling of biliary lipid from bile acid secretion by organic anions in the rat
HJ Verkade, MJ Wolbers, R Havinga, DR Uges, RJ Vonk, F Kuipers |
Gastroenterology | 1990 |
Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes
K Kobayashi, Y Sogame, H Hara, K Hayashi |
The Journal of biological chemistry | 1990 |
Cellular Mechanisms of Intrahepatic Cholestasis:
PJ Meier-Abt |
Drugs | 1990 |
Evidence for leukotriene C4 transport mediated by an ATP-dependent glutathione S-conjugate carrier in rat heart and liver plasma membranes
T Ishikawa, K Kobayashi, Y Sogame, K Hayashi |
FEBS Letters | 1989 |