Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Androgen regulation of rat renal angiotensinogen messenger RNA expression.
K E Ellison, … , M Pivor, V J Dzau
K E Ellison, … , M Pivor, V J Dzau
Published June 1, 1989
Citation Information: J Clin Invest. 1989;83(6):1941-1945. https://doi.org/10.1172/JCI114102.
View: Text | PDF
Research Article Article has an altmetric score of 1

Androgen regulation of rat renal angiotensinogen messenger RNA expression.

  • Text
  • PDF
Abstract

Renal angiotensinogen (ang-n) mRNA concentration in the male WKY rat increases significantly during puberty. Furthermore, renal angiotensinogen mRNA level in the adult female WKY rat is considerably lower than in the male. The present study investigates the role of androgen in differential renal ang-n mRNA expression. Northern and slot blot analyses with alpha-32P labeled ang-n cDNA (pRang 3) demonstrated that castration lowered ang-n mRNA levels in the male kidney by greater than or equal to 60% compared with control, suggesting that androgen may be involved with renal ang-n gene regulation. Moreover, male WKY rats castrated as weanlings and normal adult female WKY rats each implanted with testosterone displayed significant (P less than 0.05) increases in renal ang-n mRNA levels. Our observations, taken together with previous reports that androgen influences proximal tubule morphology and the tubular expression of transport proteins (e.g., Na+/H+ antiporter), may have important physiological implications for understanding the relationship between androgen and angiotensin in the regulation of tubular function.

Authors

K E Ellison, J R Ingelfinger, M Pivor, V J Dzau

×

Total citations by year

Year: 2024 2023 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1987 Total
Citations: 3 2 4 8 7 4 8 3 6 4 2 8 5 8 4 5 8 7 4 5 3 3 3 7 3 3 1 1 4 2 3 5 3 4 1 151
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (151)

Title and authors Publication Year
Hyperoxia-induced airflow restriction and Renin-Angiotensin System expression in a bronchopulmonary dysplasia mouse model.
Dowell J, Bice Z, Yan K, Konduri GG
Physiological Reports 2024
Understanding the Role of Sex Hormones in Cardiovascular Kidney Metabolic Syndrome: Toward Personalized Therapeutic Approaches
Guldan M, Unlu S, Abdel-Rahman SM, Ozbek L, Gaipov A, Covic A, Soler MJ, Covic A, Kanbay M
Journal of Clinical Medicine 2024
Sex-Specific Differences in Kidney Function and Blood Pressure Regulation
Stamellou E, Sterzer V, Alam J, Roumeliotis S, Liakopoulos V, Dounousi E
International Journal of Molecular Sciences 2024
Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome.
Stone T, Yanes Cardozo LL, Oluwatade TN, Leone CA, Burgos M, Okifo F, Pal L, Reckelhoff JF, Stachenfeld NS
American journal of physiology. Heart and circulatory physiology 2023
Sex Differences in Glomerular Lesions, in Atherosclerosis Progression, and in the Response to Angiotensin-Converting Enzyme Inhibitors in the ApoE(-/-) Mice Model.
Mallén A, Rodriguez-Urquia R, Alvarez R, Dorca-Duch E, Navarro E, Hueso M
International journal of molecular sciences 2023
Gender differences in human adrenal cortex and its disorders
X Gao, Y Yamazaki, Y Tezuka, K Omata, Y Ono, R Morimoto, Y Nakamura, F Satoh, H Sasano
Molecular and Cellular Endocrinology 2021
Reproductive Hormones
C Marsh
2021
Targeting the Endothelium to Achieve Cardioprotection
N Herrera-Zelada, U Zuñiga-Cuevas, A Ramirez-Reyes, S Lavandero, JA Riquelme
Frontiers in pharmacology 2021
Cross‐sex testosterone therapy modifies the renal morphology and function in female rats and might underlie increased systolic pressure
DC Lichtenecker, R Argeri, CH de Moura Castro, MR DiasdaSilva, GN Gomes
Clinical and experimental pharmacology & physiology 2021
Testosterone therapy in hypogonadal patients and the associated risks of cardiovascular events
ZJ Kharaba, MA Buabeid, NA Ibrahim, FJ Jirjees, HJ Obaidi, A Kaddaha, L Khajehkarimoddini, Y Alfoteih
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2020
Late‐onset hypogonadism: Reductio ad absurdum of the cardiovascular risk‐benefit of testosterone replacement therapy
F Sesti, R Pofi, M Minnetti, M Tenuta, D Gianfrilli, AM Isidori
Andrologia 2020
Effectiveness of testosterone therapy in hypogonadal patients and its controversial adverse impact on the cardiovascular system
ZJ Kharaba, MA Buabeid, YA Alfoteih
Critical Reviews in Toxicology 2020
Sex Disparities in COVID-19 Severity and Outcome: Are Men Weaker or Women Stronger?
R Pivonello, RS Auriemma, C Pivonello, AM Isidori, G Corona, A Colao, RP Millar
Neuroendocrinology 2020
Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women
YI Cortés, E Barinas-Mitchell, NS Egnot, S Bhasin, R Jasuja, N Santoro, RC Thurston
The Journal of clinical endocrinology and metabolism 2020
Targeting the renin angiotensin system for the treatment of anxiety and depression
S Chrissobolis, AN Luu, RA Waldschmidt, ME Yoakum, MS D'Souza
Pharmacology, biochemistry, and behavior 2020
Sex differences in cardiovascular actions of the renin–angiotensin system
D Medina, D Mehay, AC Arnold
Clinical Autonomic Research 2020
Brain Testosterone-CYP1B1 (Cytochrome P450 1B1) Generated Metabolite 6β-Hydroxytestosterone Promotes Neurogenic Hypertension and Inflammation
P Singh, SR Dutta, CY Song, SR Oh, FJ Gonzalez, KU Malik
Hypertension 2020
Sex differences in the metabolic effects of the renin-angiotensin system
MC White, R Fleeman, AC Arnold
Biology of sex differences 2019
Testosterone replacement therapy and cardiovascular risk.
Gagliano-Jucá T, Basaria S
Nature reviews. Cardiology 2019
TEMPORARY REMOVAL: Androgens and Blood Pressure Control: Sex Differences and Mechanisms
JF Reckelhoff
Mayo Clinic Proceedings 2019
Understanding sex differences in long-term blood pressure regulation: insights from experimental studies and computational modeling
S Ahmed, R Hu, J Leete, AT Layton
American journal of physiology. Heart and circulatory physiology 2019
Endocrine Disorders in Kidney Disease: Diagnosis and Treatment
CM Rhee, K Kalantar-Zadeh, GA Brent
2019
The potential role of myosin motor proteins in mediating the subcellular distribution of NHE3 in the renal proximal tubule
RO Crajoinas, JZ Polidoro, AC Girardi
American journal of physiology. Renal physiology 2019
Testosterone replacement therapy and cardiovascular risk
T Gagliano-Jucá, S Basaria
Nature Reviews Cardiology 2019
Vascular Type 1 Angiotensin Receptors Control Blood Pressure by Augmenting Peripheral Vascular Resistance in Female Mice
E Wolf, EJ Diaz, A Hollis, TA Hoang, HA Azad, KM Bendt, RC Griffiths, MA Sparks
American journal of physiology. Renal physiology 2018
Regulation of blood pressure is influenced by gender: A study in obese Zucker rats
M Moulana, RO Maranon
Life Sciences 2018
Gonadal hormones, but not sex, affect the acquisition and maintenance of a Go/No-Go odor discrimination task in mice
T Kunkhyen, E Perez, M Bass, A Coyne, MJ Baum, JA Cherry
Hormones and Behavior 2018
Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan
AE Stanhewicz, MM Wenner, NS Stachenfeld
American journal of physiology. Heart and circulatory physiology 2018
Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis
LC Veiras, AC Girardi, J Curry, L Pei, DL Ralph, A Tran, RC Castelo-Branco, N Pastor-Soler, CT Arranz, AS Yu, AA McDonough
Journal of the American Society of Nephrology : JASN 2017
Pediatric Hypertension
J Flynn, JR Ingelfinger, K Redwine
Pediatric Hypertension 2017
HDAC9 is an epigenetic repressor of kidney angiotensinogen establishing a sex difference
CT Bourgeois, R Satou, MC Prieto
Biology of sex differences 2017
Influence of sex on hyperfiltration in patients with uncomplicated type 1 diabetes
M Škrtić, Y Lytvyn, P Bjornstad, HN Reich, JW Scholey, P Yip, EB Sochett, B Perkins, DZ Cherney
American journal of physiology. Renal physiology 2017
Sex differences in transplantation
JD Momper, ML Misel, DB McKay
Transplantation reviews (Orlando, Fla.) 2017
Androgens and Hypertension in Men and Women: a Unifying View
C Moretti, G Lanzolla, M Moretti, L Gnessi, E Carmina
Current Hypertension Reports 2017
Sex differences in the drinking response to angiotensin II (AngII): Effect of body weight
J Santollo, AM Torregrossa, D Daniels
Hormones and Behavior 2017
Adverse health effects of androgen use
A Goldman, S Basaria
Molecular and Cellular Endocrinology 2017
6β-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone–Metabolite, Mediates Angiotensin II–Induced Renal Dysfunction in Male MiceNovelty and Significance
AK Pingili, S Thirunavukkarasu, M Kara, DD Brand, A Katsurada, DS Majid, LG Navar, FJ Gonzalez, KU Malik
Hypertension 2016
Sex differences in renal transcriptome and programmed hypertension in offspring exposed to prenatal dexamethasone
YL Tain, MS Wu, YJ Lin
Steroids 2016
Chronic Blockade of the Androgen Receptor Abolishes Age-Dependent Increases in Blood Pressure in Female Growth-Restricted RatsNovelty and Signficance
JH Dasinger, S Intapad, BR Rudsenske, GK Davis, AD Newsome, BT Alexander
Hypertension 2016
The different role of sex hormones on female cardiovascular physiology and function: not only oestrogens
S Salerni, SD Francescomarino, C Cadeddu, F Acquistapace, S Maffei, S Gallina
European Journal of Clinical Investigation 2015
Disruption of the cytochrome P -450 1B1 gene exacerbates renal dysfunction and damage associated with angiotensin II-induced hypertension in female mice
BL Jennings, JA Moore, AK Pingili, AM Estes, XR Fang, A Kanu, FJ Gonzalez, KU Malik
American journal of physiology. Renal physiology 2015
Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats
PL Dalpiaz, AZ Lamas, IF Caliman, RF Ribeiro, GR Abreu, MR Moyses, TU Andrade, SA Gouvea, MF Alves, AK Carmona, NS Bissoli, M Bader
PloS one 2015
Chronic Renal Disease
P Delanaye, AD Rule
2015
Pathophysiology and Pharmacotherapy of Cardiovascular Disease
G Jagadeesh, P Balakumar, K Maung-U
2015
Central and humoral mechanisms for arterial hypertension in women
VI Podzolkov, AE Bragina, JN Rodionova, JA Koloda
2015
Administration of an anabolic steroid during the adolescent phase changes the behavior, cardiac autonomic balance and fluid intake in male adult rats
EL Olivares, AL Silveira, FV Fonseca, C Silva-Almeida, RS Côrtes, PP Pereira-Junior, JH Nascimento, LC Reis
Physiology & Behavior 2014
Androgen-induced hypertension in angiotensinogen deficient mice: Role of 20-HETE and EETS
V Garcia, J Cheng, A Weidenhammer, Y Ding, CC Wu, F Zhang, K Gotlinger, JR Falck, ML Schwartzman
Prostaglandins & Other Lipid Mediators 2014
Enhanced Mesenteric Arterial Responsiveness to Angiotensin II Is Androgen Receptor-Dependent in Prenatally Protein-Restricted Adult Female Rat Offspring
K Sathishkumar, MP Balakrishnan, C Yallampalli
Biology of reproduction 2014
Sex and Gender Differences in Cardiovascular-Renal Diseases and Hypertension
J Reckelhoff
Colloquium Series on Integrated Systems Physiology From Molecule to Function 2014
Should There Be Sex-Specific Criteria for the Diagnosis and Treatment of Heart Failure?
LE Greiten, SJ Holditch, SP Arunachalam, VM Miller
Journal of Cardiovascular Translational Research 2013
Sex and gender differences in control of blood pressure
R Maranon, JF Reckelhoff
Clinical Science 2013
The Link Between the Renin-Angiotensin-Aldosterone System and Renal Injury in Obesity and the Metabolic Syndrome
T Thethi, M Kamiyama, H Kobori
Current Hypertension Reports 2012
Overexpression of Mouse Angiotensinogen in Renal Proximal Tubule Causes Salt-Sensitive Hypertension in Mice
J Ying, D Stuart, E Hillas, BR Gociman, N Ramkumar, JM Lalouel, DE Kohan
American Journal of Hypertension 2012
Flutamide Increases Aldosterone Levels in Gonadectomized Male But Not Female Wistar Rats
PJ Hofmann, M Michaelis, F Götz, C Bartel, T Kienitz, M Quinkler
American Journal of Hypertension 2012
The safety of postmenopausal testosterone therapy
K Maclaran, N Panay
Women s Health 2012
The “His and Hers” of the Renin-Angiotensin System
LM Hilliard, AK Sampson, RD Brown, KM Denton
Current Hypertension Reports 2012
Hypertension in Postmenopausal Women
R Lima, M Wofford, JF Reckelhoff
Current Hypertension Reports 2012
Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes
LM Yamaleyeva, S Gilliam-Davis, I Almeida, KB Brosnihan, SH Lindsey, MC Chappell
American journal of physiology. Renal physiology 2012
Testosterone Supplementation in Male Obese Zucker Rats Reduces Body Weight and Improves Insulin Sensitivity But Increases Blood Pressure
DD Davis, AL Ruiz, LL Yanes, R Iliescu, K Yuan, M Moulana, LC Racusen, JF Reckelhoff
Hypertension 2012
Hypertension in kidney androgen-regulated protein (KAP) transgenic male mice is produced by sympathetic overactivation secondary to increased oxidative stress
Maria T. Grande, Gloria Pascual, Adela S. Riolobos, Milagros Clemente Lorenzo, Beatriz Bardaji, Luz Barreiro, Olga Tornavaca, Jose Lopez-Novoa, Anna Meseguer
Free radical biology & medicine 2011
Postmenopausal Hypertension
LL Yanes, JF Reckelhoff
American Journal of Hypertension 2011
Cardiovascular-Renal and Metabolic Characterization of a Rat Model of Polycystic Ovary Syndrome
LL Yanes, DG Romero, M Moulana, R Lima, DD Davis, H Zhang, R Lockhart, LC Racusen, JF Reckelhoff
Gender Medicine 2011
Sex-related differences in pharmacokinetics and pharmacodynamics of anti-hypertensive drugs
K Ueno, H Sato
Hypertension Research 2011
Fetal and Neonatal Physiology
LH Johnson, VK Bhutani
Fetal and Neonatal Physiology 2011
Regulation of multiple renin–angiotensin system genes by Sry
A Milsted, AC Underwood, J Dunmire, HL DelPuerto, AS Martins, DL Ely, ME Turner
Journal of Hypertension 2010
Testosterone, SHBG and cardiovascular health in postmenopausal women
JS Brand, YT van der Schouw
International Journal of Impotence Research 2010
Gender and the renin-angiotensin-aldosterone system
K Komukai, S Mochizuki, M Yoshimura
Fundamental & Clinical Pharmacology 2010
Vitamins & Hormones
KJ Hare, FK Knop
Vitamins & Hormones 2010
Physiology of Kidney Renin
H Castrop, K Höcherl, A Kurtz, F Schweda, V Todorov, C Wagner
Physiological reviews 2010
Enhanced sensitivity to acute angiotensin II is testosterone dependent in adult male growth-restricted offspring
NB Ojeda, TP Royals, JT Black, JH Dasinger, JM Johnson, BT Alexander
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2010
Castration fails to prevent prenatally programmed hypertension in male rats
LL Woods, TK Morgan, JA Resko
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2010
Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain
JA Cohen, SH Lindsey, NT Pirro, KB Brosnihan, PE Gallagher, MC Chappell
American journal of physiology. Renal physiology 2010
Dihydrotestosterone stimulates aldosterone secretion by H295R human adrenocortical cells
LL Yanes, DG Romero
Molecular and Cellular Endocrinology 2009
Oral contraceptive progestins and angiotensin-dependent control of the renal circulation in humans
MA Sarna, NK Hollenberg, EW Seely, SB Ahmed
Journal of Human Hypertension 2009
Angiotensin-Converting Enzyme Genotype Affects Skeletal Muscle Strength In Elite Athletes
AM Costa, AJ Silva, N Garrido, H Louro, DA Marinho, MC Marques, L Breitenfeld
Journal of sports science & medicine 2009
Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats
LL Yanes, JC Sartori-Valinotti, R Iliescu, DG Romero, LC Racusen, H Zhang, JF Reckelhoff
American journal of physiology. Renal physiology 2009
Sex differences in the fetal programming of hypertension
D Grigore, NB Ojeda, BT Alexander
Gender Medicine 2008
Testosterone influences renal electrolyte excretion in SHR/y and WKY males
J Toot, C Jenkins, G Dunphy, S Boehme, M Hart, A Milsted, M Turner, D Ely
BMC Physiology 2008
Estrogen receptors in the kidney: Lessons from genetically altered mice
PH Lane
Gender Medicine 2008
Androgens stimulate proximal tubule transport
R Quigley
Gender Medicine 2008
Testosterone and Blood Pressure Regulation
T Kienitz, M Quinkler
Kidney and Blood Pressure Research 2008
The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease
H Kobori, M Nangaku, LG Navar, A Nishiyama
Pharmacological reviews 2007
Comprehensive Hypertension
HK Parthasarathy, TM MacDonald
Comprehensive Hypertension 2007
Sodium in Health and Disease
P Manunta, M Sciarrone
Sodium in Health and Disease: The Example of Nonsteroidal Anti-inflammatory Agents 2007
The endocrine system in chronic nitric oxide deficiency
F Vargas, JM Moreno, R Wangensteen, I Rodriguez-Gomez, J Garcia-Estan
European Journal of Endocrinology 2007
Testosterone treatment promotes tubular damage in experimental diabetes in prepubertal rats
J Sun, K Devish, WJ Langer, PK Carmines, PH Lane
American journal of physiology. Renal physiology 2007
Testosterone contributes to marked elevations in mean arterial pressure in adult male intrauterine growth restricted offspring
NB Ojeda, D Grigore, LL Yanes, R Iliescu, EB Robertson, H Zhang, BT Alexander
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2007
Vascular dysfunction during pregnancy in women with polycystic ovary syndrome
S Hu, A Leonard, A Seifalian, P Hardiman
Human Reproduction 2007
Gender Differences in the Renin-Angiotensin and Nitric Oxide Systems: Relevance in the Normal and Diseased Kidney
BB McGuire, RW Watson, F Pérez-Barriocanal, JM Fitzpatrick, NG Docherty
Kidney and Blood Pressure Research 2007
Physiology of local renin-angiotensin systems
M Paul, AP Mehr, R Kreutz
Physiological reviews 2006
Renin-angiotensin system is an important factor in hormone refractory prostate cancer
H Uemura, H Hasumi, H Ishiguro, J Teranishi, Y Miyoshi, Y Kubota
The Prostate 2006
Gender-related differences in advanced glycation endproducts, oxidative stress markers and nitric oxide synthases in rats
X Wang, K Desai, BH Juurlink, J Champlain, L Wu
Kidney International 2006
Sexual dimorphism in the renin-angiotensin system in aging spontaneously hypertensive rats
LL Yanes, DG Romero, JW Iles, R Iliescu, C Gomez-Sanchez, JF Reckelhoff
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2006
Androgens augment renal vascular responses to ANG II in New Zealand genetically hypertensive rats
J Song, CK Kost, DS Martin
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2006
Differences in decline in GFR with age between males and females. Reference data on clearances of inulin and PAH in potential kidney donors
UB Berg
Nephrology Dialysis Transplantation 2006
Background Gene Expression in Rat Kidney: Influence of Strain, Gender, and Diet
SD Seidel, SC Hung, HL Kan, BB Gollapudi
Toxicological Sciences 2006
Gender Differences in Hypertension and Kidney Disease
D Reyes, SQ Lew, PL Kimmel
Medical Clinics of North America 2005
Changes in renal hemodynamics and structure in the aging kidney; sexual dimorphism and the nitric oxide system
C Baylis
Experimental Gerontology 2005
Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease
JF Reckelhoff, LL Yanes, R Iliescu, LA Fortepiani, JP Granger
American journal of physiology. Renal physiology 2005
Sex differences in the development of angiotensin II-induced hypertension in conscious mice
B Xue, J Pamidimukkala, M Hay
American journal of physiology. Heart and circulatory physiology 2005
Testosterone enhances calcium reabsorption by the kidney
D Couchourel, M Leclerc, J Filep, MG Brunette
Molecular and Cellular Endocrinology 2004
The impact of gender on progression of renal disease: potential role of estrogen-mediated vascular endothelial growth factor regulation and vascular protection
DH Kang, ES Yu, KI Yoon, R Johnson
The American Journal of Pathology 2004
Role of sex, gonadectomy and sex hormones in the development of nitric oxide inhibition-induced hypertension: Sex hormones and l -NAME-induced hypertension
J Sáinz, A Osuna, R Wangensteen, JD Luna, I Rodríguez-Gómez, J Duarte, JM Moreno, F Vargas
Experimental Physiology 2004
The Impact of Gender on Progression of Renal Disease
DH Kang, ES Yu, KI Yoon, R Johnson
The American Journal of Pathology 2004
Androgens augment proximal tubule transport
A Quan, S Chakravarty, JK Chen, JC Chen, S Loleh, N Saini, RC Harris, J Capdevila, R Quigley
American journal of physiology. Renal physiology 2004
Interactions between gender and the angiotensin type 1 receptor gene polymorphism
H Reich, JA Duncan, J Weinstein, DC Cattran, JW Scholey, JA Miller
Kidney International 2003
Sex and the Renin Angiotensin System: Implications for Gender Differences in the Progression of Kidney Disease
K Sandberg, H Ji
Advances in renal replacement therapy 2003
Male gender increases sensitivity to renal injury in response to cholesterol loading
DM Attia, R Goldschmeding, MA Attia, P Boer, HA Koomans, JA Joles
American journal of physiology. Renal physiology 2003
Gonadal effects on plasma ACE activity in mice
YK Lim, L Retnam, B Bhagavath, SK Sethi, A Ali, SK Lim
Atherosclerosis 2002
Gender differences in steroid modulation of angiotensin II-induced protein kinase C activity in anterior pituitary of the rat
A Lachowicz, E Rębas
Biochemical and Biophysical Research Communications 2002
Diabetic kidney disease: impact of puberty
PH Lane
American journal of physiology. Renal physiology 2002
Functional analysis and androgen-regulated expression of mouse organic anion transporting polypeptide 1 (Oatp1) in the kidney
J Isern
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 2001
Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice
Y Ding, CD Sigmund
American journal of physiology. Renal physiology 2001
Gender Differences in the Regulation of Blood Pressure
JF Reckelhoff
Hypertension 2001
Testicular hormonal regulation of the renin-angiotensin system in the rat epididymis
PS Leung, TP Wong, SY Lam, HC Chan, PY Wong
Life Sciences 2000
Male gender increases sensitivity to proteinuria induced by mild NOS inhibition in rats: role of sex hormones
AM Verhagen, DM Attia, HA Koomans, JA Joles
American journal of physiology. Renal physiology 2000
Androgen regulation and site specificity of angiotensinogen gene expression and secretion in rat adipocytes
V Serazin-Leroy, M Morot, P Mazancourt, Y Giudicelli
American journal of physiology. Endocrinology and metabolism 2000
Gender Differences in Development of Hypertension in Spontaneously Hypertensive Rats: Role of the Renin-Angiotensin System
JF Reckelhoff, H Zhang, K Srivastava
Hypertension 2000
Appropriate Tissue- and Cell-specific Expression of a Single Copy Human Angiotensinogen Transgene Specifically Targeted Upstream of the HPRT Locus by Homologous Recombination
B Cvetkovic, B Yang, RA Williamson, CD Sigmund
The Journal of biological chemistry 2000
Catecholamines and angiotensinogen gene expression in kidney proximal tubular cells
J S Chan, T T Wang, S L Zhang, X Chen, S Carrière
Molecular and Cellular Biochemistry 2000
Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-kappaB (NF-kappaB) transcription factor
A R Brasier, M Jamaluddin, Y Han, C Patterson, M S Runge
Molecular and Cellular Biochemistry 2000
ROLE OF ANDROGENS IN MEDIATING HYPERTENSION AND RENAL INJURY
JF Reckelhoff, JP Granger
Clinical and Experimental Pharmacology and Physiology 1999
Neonatal sympathectomy reduces adult blood pressure and cardiovascular pathology in Y chromosome consomic rats
DH Hamid
Blood Pressure 1999
Rat proximal tubule cell line transformed with origin-defective SV40 DNA: autocrine ANG II feedback
JR Ingelfinger, F Jung, D Diamant, L Haveran, E Lee, A Brem, SS Tang
American journal of physiology. Renal physiology 1999
Female Wistar–Kyoto and SHR/y rats have the same genotype but different patterns of expression of renin and angiotensinogen genes
A Milsted, MC Marcelo, ME Turner, DL Ely
Journal of Hypertension 1998
Androgen metabolism in cultured rat renal inner medullary collecting duct (IMCD) cells
K Matsuzaki, T Arai, T Inumaru, M Mihori, T Momose, M Sano, K Koide, N Shimizu
Steroids 1998
Testosterone Exacerbates Hypertension and Reduces Pressure-Natriuresis in Male Spontaneously Hypertensive Rats
JF Reckelhoff, H Zhang, JP Granger
Hypertension 1998
Decline in Renal Hemodynamic Function in Aging SHR: Role of Androgens
JF Reckelhoff, H Zhang, JP Granger
Hypertension 1997
Molecular Reviews in Cardiovascular Medicine
K Lindpaintner, D Ganten
1996
The impact of gender on the progression of chronic renal disease
SR Silbiger, J Neugarten
American Journal of Kidney Diseases 1995
Reproduction and the renin-angiotensin system
WF Ganong
Neuroscience & Biobehavioral Reviews 1995
Developmental consequences of the renin-angiotensin system
RA Gomez, VF Norwood
American Journal of Kidney Diseases 1995
In situ hybridization and immunohistochemistry of renal angiotensinogen in neonatal and adult rat kidneys
IA Darby, C Sernia
Cell and Tissue Research 1995
Sexual Dimorphism of Urine Angiotensinogen Excretion in the Rat
E Wang, K Yayama, M Takano, H Okamoto
The Japanese Journal of Pharmacology 1994
Functional expression of the human angiotensinogen gene in transgenic mice
G Yang, DC Merrill, MW Thompson, JE Robillard, CD Sigmund
The Journal of biological chemistry 1994
Cellular expression of angiotensin type-1 receptor mRNA in the kidney
B Meister, A Lippoldt, B Bunnemann, T Inagami, D Ganten, K Fuxe
Kidney International 1993
Feedback regulation of angiotensin converting enzyme activity and mRNA levels by angiotensin II
H Schunkert, JR Ingelfinger, AT Hirsch, Y Pinto, WJ Remme, H Jacob, VJ Dzau
Circulation research 1993
The Arterial System in Hypertension
ME Safar, MF ORourke
1993
Evidence for tissue-specific activation of renal angiotensinogen mRNA expression in chronic stable experimental heart failure
H Schunkert, JR Ingelfinger, AT Hirsch, SS Tang, SE Litwin, CE Talsness, VJ Dzau
Journal of Clinical Investigation 1992
Reciprocal feedback regulation of kidney angiotensinogen and renin mRNA expressions by angiotensin II
H Schunkert, JR Ingelfinger, H Jacob, B Jackson, B Bouyounes, VJ Dzau
American journal of physiology. Endocrinology and metabolism 1992
Differential effects of captopril and enalapril on tissue renin-angiotensin systems in experimental heart failure
AT Hirsch, CE Talsness, AD Smith, H Schunkert, JR Ingelfinger, VJ Dzau
Circulation 1992
Androgen-dependent angiotensinogen and renin messenger RNA expression in hypertensive rats
YF Chen, AJ Naftilan, S Oparil
Hypertension 1992
Sex Steroids and the Cardiovascular System
PW Ramwell, GM Rubanyi, E Schillinger
1992
Angiotensin actions in the kidney: Renewed insight into the old hormone
I Ichikawa, RC Harris
Kidney International 1991
Androgen receptors in osteoblast-like cell lines
ES Orwoll, L Stribrska, EE Ramsey, EJ Keenan
Calcified Tissue International 1991
Molecular biology of angiotensinogen
KR Lynch, MJ Peach
Hypertension 1991
In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule. An hypothesis for the intrarenal renin angiotensin system
JR Ingelfinger, WM Zuo, EA Fon, KE Ellison, VJ Dzau
Journal of Clinical Investigation 1990
Potential role of the tissue renin-angiotensin system in the pathophysiology of congestive heart failure
AT Hirsch, YM Pinto, H Schunkert, VJ Dzau
The American Journal of Cardiology 1990
Adrenal androgen excretion during adrenarche. Relation to race and blood pressure
JH Pratt, AK Manatunga, MA Wagner, JJ Jones, FJ Meaney
Hypertension 1990
Intrarenal angiotensinogen: localization and regulation
JR Ingelfinger, H Schunkert, KE Ellison, M Pivor, WM Zuo, R Pratt, VJ Dzau
Pediatric Nephrology 1990
Congestive Heart Failure
L Werkö
Acta Medica Scandinavica 1987

← Previous 1 2 3 … 6 7 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

On 1 videos
32 readers on Mendeley
See more details