Citations to this article

Normal human intestinal B lymphocytes. Increased activation compared with peripheral blood.
M G Peters, … , S R Rich, R P MacDermott
M G Peters, … , S R Rich, R P MacDermott
Published June 1, 1989
Citation Information: J Clin Invest. 1989;83(6):1827-1833. https://doi.org/10.1172/JCI114088.
View: Text | PDF
Research Article

Normal human intestinal B lymphocytes. Increased activation compared with peripheral blood.

Abstract

The state of activation of normal human intestinal mononuclear cells obtained from transplant donors was studied. Compared with PBMC, freshly isolated intestinal mononuclear cells expressed significantly more cell surface activation antigens on both B and T lymphocytes. Intestinal mononuclear cells contained significant numbers of immunoglobulin secreting cells immediately after cell separation. This population included CD5-positive B cells that secreted predominantly IgA. Cells from the large bowel consistently revealed higher numbers of IgA secreting cells than cells from the small bowel. Thus, intestinal B cells are markedly activated in vivo compared with PBMC and this increased activation correlates with increased spontaneous antibody secretion. B cells from the large intestine are more highly activated and secrete more antibody than do cells from the small intestine. The intestinal lamina propria lymphoid compartment exhibits a heightened state of activation that may be important for its distinct role in mucosal defense.

Authors

M G Peters, H Secrist, K R Anders, G S Nash, S R Rich, R P MacDermott

×

Total citations by year

Year: 2015 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 Total
Citations: 5 2 2 3 3 3 3 5 3 3 4 4 5 1 46
Citation information

Citations to this article (46)

Title and authors Publication Year
Crossroads Between Innate and Adaptive Immunity V
SP Schoenberger, PD Katsikis, B Pulendran 		2015
Crossroads Between Innate and Adaptive Immunity V
SP Schoenberger, PD Katsikis, B Pulendran 		2015
Crossroads Between Innate and Adaptive Immunity V
SP Schoenberger, PD Katsikis, B Pulendran 		2015
Crossroads Between Innate and Adaptive Immunity V
SP Schoenberger, PD Katsikis, B Pulendran 		2015
Crossroads Between Innate and Adaptive Immunity V
SP Schoenberger, PD Katsikis, B Pulendran 		2015
Mucosal Plasma Cell Repertoire During HIV-1 Infection
RW Scamurra, DB Nelson, XM Lin, DJ Miller, GJ Silverman, T Kappel, JR Thurn, E Lorenz, A Kulkarni-Narla, EN Janoff 		Journal of immunology (Baltimore, Md. : 1950) 2002
The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression
F Medina, C Segundo, A Campos-Caro, I González-Garcı́a, JA Brieva 		Blood 2002
The mucosal immune system: from specialized immune defense to inflammation and allergy
H Kiyono, MN Kweon, T Hiroi, I Takahashi 		Acta Odontologica Scandinavica 2001
A Preponderance of CCR5 + CXCR4 + Mononuclear Cells Enhances Gastrointestinal Mucosal Susceptibility to Human Immunodeficiency Virus Type 1 Infection
MA Poles, J Elliott, P Taing, PA Anton, IS Chen 		Journal of virology 2001
Immunoglobulin A cell distribution in the human small intestine: phenotypic and functional characteristics
IN Farstad, H Carlsen, HC Morton, P Brandtzaeg 		Immunology 2000
Regulation of Immunoglobulin Secretion by Plasma Cells Infiltrating Nasal Polyps: Regulation of Immunoglobulin Secretion by Plasma Cells Infiltrating Nasal Polyps
A Sánchez-Segura, JA Brieva, C Rodríguez 		The Laryngoscope 2000
IL-15 and IL-15 Receptor Selectively Regulate Differentiation of Common Mucosal Immune System-Independent B-1 Cells for IgA Responses
T Hiroi, M Yanagita, N Ohta, G Sakaue, H Kiyono 		Journal of immunology (Baltimore, Md. : 1950) 2000
Human Immunodeficiency Virus Type 1 and Mucosal Humoral Defense
EN Janoff, RW Scamurra, TC Sanneman, K Eidman, JR Thurn 		The Journal of Infectious Diseases 1999
Induction of Interleukin-15 Production by HIV-1 Nef Protein: A Role in the Proliferation of Uninfected Cells
MG Quaranta, B Camponeschi, E Straface, W Malorni, M Viora 		Experimental Cell Research 1999
IgG1 production by sIgD+ splenic B cells and peritoneal B-1 cells in response to IL-5 and CD38 ligation
T Yasue, M Baba, S Mori, C Mizoguchi, S Uehara, K Takatsu 		International Immunology 1999
Cafeteria feeding induces interleukin-1β mRNA expression in rat liver and brain
MK Hansen, P Taishi, Z Chen, JM Krueger 		American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 1998
Lack of immunotoxicity of saquinavir (Ro 31-8959) used alone or in double or triple combination with AZT and ddC
M Viora, G Di Genova, M G Quaranta, M Boirivant, B Camponeschi 		Journal of Clinical Immunology 1998
HIV-1 gp120 accelerates Fas-mediated activation-induced human lamina propria T cell apoptosis
M Boirivant, M Viora, L Giordani, A L Luzzati, A M Pronio, C Montesani, O Pugliese 		Journal of Clinical Immunology 1998
Sequence analysis of human IgVH genes indicates that ileal lamina propria plasma cells are derived from Peyer's patches
DK Dunn-Walters, PG Isaacson, J Spencer 		European Journal of Immunology 1997
ADVANCES IN MUCOSAL IMMUNOLOGY
I McGowan, A Chalmers, GR Smith, D Jewell 		Gastroenterology Clinics of North America 1997
Isolation and purification of CD14-negative mucosal macrophages from normal human small intestine
PD Smith, EN Janoff, M Mosteller-Barnum, M Merger, JM Orenstein, JF Kearney, MF Graham 		Journal of Immunological Methods 1997
Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis
M Boirivant, R Pica, R DeMaria, R Testi, F Pallone, W Strober 		Journal of Clinical Investigation 1996
Alterations of the mucosal immune system in inflammatory bowel disease
RP MacDermoit 		Journal of Gastroenterology 1996
Essentials of Mucosal Immunology
DK Podolsky 		Essentials of Mucosal Immunology 1996
Gut Dysfunction in Critical Illness
JL Rombeau, J Takala 		1996
Circulating immunoglobulin G can play a critical role in clearance of intestinal reovirus infection
ML Barkon, BL Haller, HW th 		Journal of virology 1996
IgA production by peritoneal cavity B cells is IL-6 independent: Implications for intestinal IgA response
KW Beagley, S Bao, AJ Ramsay, JH Eldridge, AJ Husband 		European Journal of Immunology 1995
Pitfalls in the characterization of small intestinal lymphocytes
EC Ebert, AI Roberts 		Journal of Immunological Methods 1995
Advances in Mucosal Immunology
J Mestecky, MW Russell, S Jackson, SM Michalek, H Tlaskalová-Hogenová, J Šterzl 		1995
Handbook of Mucosal Immunology
D Nadal, CP Braegger, P Knoflach, B Albini 		Handbook of Mucosal Immunology 1994
Alterations in the mucosal immune system in ulcerative colitis and crohn's disease
RP MacDermott 		Medical Clinics of North America 1994
Vasoactive intestinal polypeptide modulates the in vitro immunoglobulin a production by intestinal lamina propria lymphocytes
M Boirivant, S Fais, B Annibale, D Agostini, GD Fave, F Pallone 		Gastroenterology 1994
Increased spontaneous secretion of rheumatoid factor by intestinal lamina propria mononuclear cells from Crohn's disease but not ulcerative colitis patients
RP MacDERMOTT, S Schreiber, GS Nash, WJ Koopman 		Clinical & Experimental Immunology 1993
A possible paradox in the immunology of multiple sclerosis: Its apparent lack of ‘specificity’ might provide clues to the etiology
K Lauer 		Medical Hypotheses 1993
Immune activation genes in inflammatory bowel disease
T Matsuura, GA West, KR Youngman, JS Klein, C Fiocchi 		Gastroenterology 1993
Increased spontaneous secretion of rheumatoid factor by intestinal lamina propria mononuclear cells from Crohn's disease but not ulcerative colitis patients.
MacDermott RP, Schreiber S, Nash GS, Koopman WJ 		Clinical & Experimental Immunology 1993
Structure and expression of the mb-1 transcript in human lymphoid cells
I Leduc, JL Preud'homme, M Cogné 		Clinical & Experimental Immunology 1992
Increased in vitro release of soluble interleukin 2 receptor by colonic lamina propria mononuclear cells in inflammatory bowel disease
S Schreiber, A Raedler, AR Conn, JL Rombeau, RP MacDermott 		Gut 1992
THE ROLE OF THE MUCOSAL IMMUNE SYSTEM IN INFLAMMATORY BOWEL DISEASE
S Schreiber, A Raedler, WF Stenson, RP MacDermott 		Gastroenterology Clinics of North America 1992
Structure and expression of the mb-1 transcript in human lymphoid cells.
Leduc I, Preud'homme JL, Cogné M 		Clinical & Experimental Immunology 1992
Intestinal immune responses in humans. Oral cholera vaccination induces strong intestinal antibody responses and interferon-gamma production and evokes local immunological memory
M Quiding, I Nordström, A Kilander, G Andersson, LA Hanson, J Holmgren, C Czerkinsky 		Journal of Clinical Investigation 1991
Size, CD4 and CDS Marker Profiles and Functions of Lymphocyte Subpopulations in Mucosal-Associated Lymph Nodes
MJ Dobrzanski, TJ Yang 		Immunological Investigations 1991
Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease
S Schreiber, RP MacDermott, A Raedler, R Pinnau, MJ Bertovich, GS Nash 		Gastroenterology 1991
Interactions between Helicobacter pylori and the Local Mucosal Immune System
PB Ernst, S Pecquet 		Scandinavian Journal of Gastroenterology 1991
Immunology of Milk and the Neonate
J Mestecky, C Blair, PL Ogra 		1991
Oxidant defense mechanisms in the human colon
MB Grisham, RP MacDermott, EA Deitch 		Inflammation 1990

Advertisement