JCI - Citations to Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

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Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

T F Byrd, M A Horwitz

Published May 1, 1989
Citation Information: J Clin Invest. 1989;83(5):1457-1465. https://doi.org/10.1172/JCI114038.

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Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

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Abstract

We have investigated the role of iron in the intracellular biology of Legionella pneumophila in human monocytes and in the effector arm of cell-mediated immune defense against this intracellular bacterial pathogen. To determine if L. pneumophila intracellular multiplication is iron dependent, we studied the effect of the iron chelator deferoxamine on L. pneumophila infection of monocytes. Deferoxamine at 15 microM completely inhibited L. pneumophila intracellular multiplication. The inhibitory effect of deferoxamine was reversed with equimolar iron-saturated transferrin but not apotransferrin. To examine the potential role of iron in monocyte activation, we investigated the influence of iron-saturated transferrin on L. pneumophila multiplication in IFN gamma-activated monocytes. Iron transferrin, but not apotransferrin, neutralized the capacity of activated monocytes to inhibit L. pneumophila multiplication. To explore a potential mechanism by which activated monocytes might limit the availability of intracellular iron, we examined transferrin receptor expression on nonactivated and activated monocytes cultured in vitro for 5 d. By fluorescence-activated flow cytometry, activated monocytes exhibited markedly fewer transferrin receptors than nonactivated monocytes. By Scatchard analysis of 125I-transferrin binding to monocytes, nonactivated monocytes had 38,300 +/- 12,700 (mean +/- SE) transferrin binding sites, whereas activated monocytes had 10,300 +/- 1,600, a reduction of 73%. Activated and nonactivated monocytes had a similar mean Kd (1.8 +/- 0.2 nM). This study demonstrates that (a) L. pneumophila intracellular multiplication is iron dependent; (b) activated monocytes inhibit L. pneumophila multiplication by limiting the availability of intracellular iron; and (c) transferrin receptors are downregulated on IFN gamma-activated monocytes.

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T F Byrd, M A Horwitz

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Brucella abortus strain 2308 produces brucebactin, a highly efficient catecholic siderophore MI Carreró, JM Lobo, FJ Sangari, J Agüero	Microbiology	2002
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Community-Acquired Pneumonia TJ Marrie		2002
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Phagocytosis and killing of intracellular pathogens: interaction between cytokines and antibiotics Y Ouadrhiri, Y Sibille	Current Opinion in Infectious Diseases	2000
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Modulation of intramacrophage iron metabolism during microbial cell invasion ED Weinberg	Microbes and Infection	2000
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Defense mechanisms against infections HY Reynolds	Current Opinion in Pulmonary Medicine	1999
The transferrin receptor: role in health and disease P Ponka, CN Lok	The International Journal of Biochemistry & Cell Biology	1999
Iron and infection SI Patruta, WH Horl	Kidney International	1999
Ferric reduction is a potential iron acquisition mechanism for Histoplasma capsulatum MM Timmerman, JP Woods	Infection and immunity	1999
Advances in Cellular and Molecular Biology of Membranes and Organelles MA Horwitz, DL Clemens	Advances in Cellular and Molecular Biology of Membranes and Organelles	1999
Effects of iron deprivation on Mycobacterium avium growth MS Gomes, G Dom, J Pedrosa, JR Boelaert, R Appelberg	Tubercle and Lung Disease	1999
Oxygen-Independent Microbicidal Mechanisms of Phagocytes T Ganz	Proceedings of The Association of American Physicians	1999
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Fatal attraction of mammalian cells toLegionella pneumophila YA Kwaik	Molecular Microbiology	1998
Review Article Erratic behavior of nitric oxide within the immune system: illustrative review of conflicting data and their immunopharmacological aspects Z Zidek, K Mašek	International Journal of Immunopharmacology	1998
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Encyclopedia of Immunology RL Riley	Encyclopedia of Immunology	1998
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Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes TF Byrd	Journal of Clinical Investigation	1997
Response of Chlamydia trachomatis serovar E to iron restriction in vitro and evidence for iron-regulated chlamydial proteins JE Raulston	Infection and immunity	1997
Ehrlichia chaffeensis inclusions are early endosomes which selectively accumulate transferrin receptor RE Barnewall, Y Rikihisa, EH Lee	Infection and immunity	1997
Bafilomycin A1 and intracellular multiplication of Legionella pneumophila L Cattani, P Goldoni, MC Pastoris, L Sinibaldi, N Orsi	Antimicrobial agents and chemotherapy	1997
An iron- and fur-repressed Legionella pneumophila gene that promotes intracellular infection and encodes a protein with similarity to the Escherichia coli aerobactin synthetases EK Hickey, NP Cianciotto	Infection and immunity	1997
Hemosiderin deposition in portal endothelial cells is a histologic marker predicting poor response to interferon-α therapy in chronic hepatitis C K Kaji, Y Nakanurna, K Harada, A Sakai, S Kaneko, K Kobayash	Pathology International	1997
Differential Effects of Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) in Enhancing Macrophage Resistance toLegionella pneumophilavsCandida albicans Y Yamamoto, TW Klein, M Tomioka, H Friedman	Cellular Immunology	1997
Antigenic and genetic characterization of Leaionella Proteins: Contribution to taxonomy, diagnosis and pathogenesis JM Bangsborg	APMIS	1997
Phenotyping and Cytokine Regulation of the BEAS-2B Human Bronchial Epithelial Cell: Demonstration of Inducible Expression of the Adhesion Molecules VCAM-1 and ICAM-1 J Atsuta, SA Sterbinsky, J Plitt, LM Schwiebert, BS Bochner, RP Schleimer	American journal of respiratory cell and molecular biology	1997
Polyvalent Cationic Metals Induce the Rate of Transferrin-independent Iron Acquisition by HL-60 Cells O Olakanmi, JB Stokes, S Pathan, BE Britigan	The Journal of biological chemistry	1997
Lactoferrin TW Hutchens, B Lönnerdal		1997
Analysis of the Intracellular Fate of Legionella pneumophila Mutants MS Swanson, RR Isberg	Annals of the New York Academy of Sciences	1996
Gamma interferon protects endothelial cells from damage by Candida albicans by inhibiting endothelial cell phagocytosis RA Fratti, MA Ghannoum, JE Edwards, SG Filler	Infection and immunity	1996
Effector mechanisms responsible for gamma interferon-mediated host resistance to Legionella pneumophila lung infection: the role of endogenous nitric oxide differs in susceptible and resistant murine hosts L Heath, C Chrisp, G Huffnagle, M LeGendre, Y Osawa, M Hurley, C Engleberg, J Fantone, J Brieland	Infection and immunity	1996
De novo synthesis of Legionella pneumophila antigens during intracellular growth in phagocytic cells M Susa, J Hacker, R Marre	Infection and immunity	1996
Exochelins of Mycobacterium tuberculosis remove iron from human iron-binding proteins and donate iron to mycobactins in the M. tuberculosis cell wall J Gobin, MA Horwitz	Journal of Experimental Medicine	1996
A Legionella pneumophila gene that promotes hemin binding WA O'Connell, EK Hickey, NP Cianciotto	Infection and immunity	1996
Legionella pneumophila mutants that are defective for iron acquisition and assimilation and intracellular infection CD Pope, W O'Connell, NP Cianciotto	Infection and immunity	1996
Effects of Interferon-α, β, and γ on the Function of Differentiated Leukemic HL-60 Cells Induced by 1,25-Dihydroxyvitamin D3 M Watanabe, Y Shimamoto, T Matsumoto, SI Yoshida, O Kohashi, T Sunaga	Journal of Interferon & Cytokine Research	1996
The use of deferoxamine infusions to enhance the response rate to interferon-α treatment of chronic viral hepatitis B Y Bayraktar, T Koseoglu, C Somner, B Kayhan, A Temizer, B Uzunalimoglu, ND Maria, DH van Thiel	Journal of Viral Hepatitis	1996
Advances in Structural Biology A Ghahary, P Rajeet, EE Tredget	Advances in Structural Biology	1996
Effects of Interferon-α, β, and γ on the Function of Differentiated Leukemic HL-60 Cells Induced by 1,25-Dihydroxyvitamin D 3 M Watanabe, Y Shimamoto, T Matsumoto, SI Yoshida, O Kohashi, T Sunaga	Journal of Interferon & Cytokine Research	1996
Molecular Biology of Hematopoiesis 5 NG Abraham, S Asano, G Brittinger, GJ Maestroni, RK Shadduck		1996
Bacterial Invasiveness VL Miller		1996
Respiratory infections: Community-acquired pneumonia and newer microbes HY Reynolds	Lung	1996
In vivo regulation of replicative Legionella pneumophila lung infection by endogenous tumor necrosis factor alpha and nitric oxide JK Brieland, DG Remick, PT Freeman, MC Hurley, JC Fantone, NC Engleberg	Infection and immunity	1995
Intraphagocytic growth induces an antibiotic-resistant phenotype of Legionella pneumophila J Barker, H Scaife, MR Brown	Antimicrobial agents and chemotherapy	1995
Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins J Gobin, CH Moore, JR Reeve, DK Wong, BW Gibson, MA Horwitz	Proceedings of the National Academy of Sciences	1995
Influence of iron-limited continuous culture on physiology and virulence of Legionella pneumophila BW James, WS Mauchline, RB Fitzgeorge, PJ Dennis, CW Keevil	Infection and immunity	1995
Decreased capacity of aged mice to produce interferon-gamma in Legionella pneumophila infection H Fujio, I Kawamura, H Miyamoto, M Mitsuyama, S Yoshida	Mechanisms of Ageing and Development	1995
Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility gene MC Beckers, S Yoshida, K Morgan, E Skamene, P Gros	Mammalian Genome	1995
Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis SL Newman, L Gootee, G Brunner, GS Deepe	Journal of Clinical Investigation	1994
Differences and similarities in permissive A/J versus non-permissive BALB/c murine macrophages infected with Legionella pneumophila: The role of iron SJ Gebran, Y Yamamoto, S McHugh, C Newton, TW Klein, H Friedman	FEMS Immunology and Medical Microbiology	1994
Cytokines and legionellosis TF Byrd	Biotherapy	1994
Cytokines in the treatment of leishmaniasis: From studies of immunopathology to patient therapy JL Ho, R Badaro, D Hatzigeorgiou, SG Reed, WD Johnson	Biotherapy	1994
Macrophage permissiveness for Legionella pneumophila growth modulated by iron SJ Gebran, C Newton, Y Yamamoto, R Widen, TW Klein, H Friedman	Infection and immunity	1994
2-Deoxy-D-glucose inhibits intracellular multiplication and promotes intracellular killing of Legionella pneumophila in A/J mouse macrophages M Ogawa, S Yoshida, Y Mizuguchi	Infection and immunity	1994
Inhibition of Legionella pneumophila growth by gamma interferon in permissive A/J mouse macrophages: role of reactive oxygen species, nitric oxide, tryptophan, and iron(III) SJ Gebran, Y Yamamoto, C Newton, TW Klein, H Friedman	Infection and immunity	1994
Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice. A murine model of human Legionnaires' disease J Brieland, P Freeman, R Kunkel, C Chrisp, M Hurley, J Fantone, C Engleberg	The American Journal of Pathology	1994
Abrogation of gamma interferon-induced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron-transferrin RE Barnewall, Y Rikihisa	Infection and immunity	1994
Difference in Legionella pneumophila growth permissiveness between J774.1 murine macrophage-like JA-4 cells and lipopolysaccharide (LPS)-resistant mutant cells, LPS1916, after stimulation with LPS F Kura, K Suzuki, H Watanabe, Y Akamatsu, F Amano	Infection and immunity	1994
Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2 HS Shin, BE Drysdale, ML Shin, PW Noble, SN Fisher, WA Paznekas	Molecular and cellular biology	1994
Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin LE Cano, B Gomez, E Brummer, A Restrepo, DA Stevens	Infection and immunity	1994
Mechanisms involved in uptake of Bordetella bronchiseptica by mouse dendritic cells CA Guzman, M Rohde, KN Timmis	Infection and immunity	1994
Nitrite production by macrophages derived from BCG-resistant and -susceptible congenic mouse strains in response to IFN-gamma and infection with BCG LF Barrera, I Kramnik, E Skamene, D Radzioch	Immunology	1994
Iron and Immunity JH Brock	Journal of Nutritional Immunology	1994
Cloning and sequencing of the Legionella pneumophila fur gene EK Hickey, NP Cianciotto	Gene	1994
Response to interferon α therapy is influenced by the iron content of the liver DH van Thiel, L Friedlander, S Fagiuoli, HI Wright, W Irish, JS Gavaler	Journal of Hepatology	1994
11 Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators C Hershko	Baillière's Clinical Haematology	1994
Host defenses against respiratory infection SJ Skerrett	Medical Clinics of North America	1994
Lactoferrin Structure and Function TW Hutchens, SV Rumball, B Lönnerdal		1994
Pulmonary Infections and Immunity H Chmel, M Bendinelli, H Friedman		1994
Cytokines in the Treatment of Infectious Diseases BJ Kullberg, JW Meer		1994
LIFE-THREATENING PNEUMONIA K Gleeson, HY Reynolds	Clinics in Chest Medicine	1994
Iron sequestration by macrophages decreases the potential for extracellular hydroxyl radical formation O Olakanmi, SE McGowan, MB Hayek, BE Britigan	Journal of Clinical Investigation	1993
Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon gamma TF Byrd, MA Horwitz	Journal of Clinical Investigation	1993
Interferon-gamma and resistance to bacterial infections CW Czarniecki, G Sonnenfeld	APMIS	1993
Iron, infection and immune function C Hershko	Proceedings of the Nutrition Society	1993
The major iron-containing protein of Legionella pneumophila is an aconitase homologous with the human iron-responsive element-binding protein JM Mengaud, MA Horwitz	Journal of bacteriology	1993
Identification of Legionella pneumophila genes required for growth within and killing of human macrophages AB Sadosky, LA Wiater, HA Shuman	Infection and immunity	1993
Biosynthesis of nitric oxide activates iron regulatory factor in macrophages JC Drapier, H Hirling, J Wietzerbin, P Kaldy, LC Kühn	The EMBO Journal	1993
Differences in transferrin response and numbers of transferrin receptors in rat and human mammary carcinoma lines of different metastatic potentials T Inoue, PG Cavanaugh, PA Steck, N Br�nner, GL Nicolson	Journal of Cellular Physiology	1993
Iron acquisition in microbial pathogenesis SM Payne	Trends in Microbiology	1993
Macrophage control of Brucella abortus: influence of cytokines and iron CL Baldwin, X Jiang, DM Fernandes	Trends in Microbiology	1993
T Cell Involvement in Resistance to Facultative Intracellular Pathogens of the Lung PA Campbell	Chest	1993
Fungal Infections and Immune Responses JW Murphy, H Friedman, M Bendinelli		1993
Iron chelators in medicine C Hershko	Molecular Aspects of Medicine	1992
Investigation of the role of macrophages and endogenous interferon-Î³ in natural resistance of mice againstLegionella pneumophilainfection H Fujio, S Yoshida, H Miyamoto, M Mitsuyama, Y Mizuguchi	FEMS Microbiology Letters	1992
Differential morphologic and metabolic alterations in permissive versus nonpermissive murine macrophages infected with Legionella pneumophila Y Yamamoto, TW Klein, K Brown, H Friedman	Infection and immunity	1992
Macrophage activation for intracellular killing as induced by a Ca2+ ionophore. Dependence on L-arginine-derived nitrogen oxidation products Y Buchmüller-Rouiller, SB Corradin, J Mauël	Biochemical Journal	1992
L-arginine-dependent killing of intracellular Ehrlichia risticii by macrophages treated with gamma interferon J Park, Y Rikihisa	Infection and immunity	1992
Intracellular growth inhibition of Histoplasma capsulatum induced in murine macrophages by recombinant gamma interferon is not due to a limitation of the supply of methionine or cysteine to the fungus BA Wu-Hsieh, DH Howard	Infection and immunity	1992
Activation of macrophages for destruction of Francisella tularensis: identification of cytokines, effector cells, and effector molecules AH Fortier, T Polsinelli, SJ Green, CA Nacy	Infection and immunity	1992
Cytokines, Toxoplasma and Intracellular Parasitism MH Beaman, SY Wong, JS Remington	Immunological Reviews	1992
Comparative ability of human monocytes and macrophages to control the intracellular growth ofMycobacterium aviumandMycobacterium tuberculosis: effect of interferon-gamma and indomethacin JP Sousa, N Rastogi	FEMS Microbiology Letters	1992
Iron depletion: A defense against intracellular infection and neoplasia ED Weinberg	Life Sciences	1992
Transposon mutagenesis in Legionella pneumophila M Tully, A Williams, RB Fitzgeorge	Research in Microbiology	1992
Mononuclear Phagocytes R van Furth		1992
Macrophage Biology and Activation SW Russell, S Gordon		1992
Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens TF Byrd, MA Horwitz	Journal of Clinical Investigation	1991
Lactoferrin inhibits or promotes Legionella pneumophila intracellular multiplication in nonactivated and interferon gamma-activated human monocytes depending upon its degree of iron saturation. Iron-lactoferrin and nonphysiologic iron chelates reverse mon TF Byrd, MA Horwitz	Journal of Clinical Investigation	1991
Role of nitric oxide synthesis in macrophage antimicrobial activity CF Nathan, JB Hibbs	Current Opinion in Immunology	1991
Suppression by human recombinant gamma interferon of in vitro macrophage nonopsonic and opsonic phagocytosis and killing DP Speert, L Thorson	Infection and immunity	1991
Acquisition of iron by Legionella pneumophila: role of iron reductase W Johnson, L Varner, M Poch	Infection and immunity	1991
Gamma interferon-activated human macrophages and Toxoplasma gondii, Chlamydia psittaci, and Leishmania donovani: antimicrobial role of limiting intracellular iron HW Murray, AM Granger, RF Teitelbaum	Infection and immunity	1991
Role of transferrin, transferrin receptors, and iron in macrophage listericidal activity CE Alford, TE King, PA Campbell	Journal of Experimental Medicine	1991
Inhibition of Ehrlichia risticii infection in murine peritoneal macrophages by gamma interferon, a calcium ionophore, and concanavalin A J Park, Y Rikihisa	Infection and immunity	1991
Iron limitation and the gamma interferon-mediated antihistoplasma state of murine macrophages TE Lane, BA Wu-Hsieh, DH Howard	Infection and immunity	1991
Nitric oxide and host defence RG Kilbourn	Research in Immunology	1991
Activation of human monocyte-derived macrophages by interferon γ is accompanied by increase of poly(ADP-ribose) polymerase activity G Berton, C Sorio, C Laudanna, M Menegazzi, AC Prati, H Suzuki	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	1991
Iron and bacterial virulence ? a brief overview E Griffiths	Biology of Metals	1991
Legionellosis MH Nguyen, JE Stout, VL Vu	Infectious Disease Clinics of North America	1991
Dietary and prophylactic iron supplements S Kent, ED Weinberg, P Stuart-Macadam	Human Nature	1990
Bacteria-phagocyte interactions: emerging tactics in an ancient rivalry AS Cross, NM Kelly	FEMS Microbiology Letters	1990
Prooxidant activity of transferrin and lactoferrin SJ Klebanoff, AM Waltersdorph	Journal of Experimental Medicine	1990
Cellular Iron Metabolism in Health and Diseased ED Weinberg	Drug Metabolism Reviews	1990
Organización funcional del macrófago alveolar JL Arellano, JE García, MJ Martín, MC Montero, AJ López, MC Sánchez	Archivos de Bronconeumología	1990
Dietary and prophylactic iron supplements: Helpful or harmful? S Kent, ED Weinberg, P Stuart-Macadam	Human Nature	1990
Clinical Approach to Infection in the Compromised Host RH Rubin, LS Young		1988

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Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

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