Hypertension causes biochemical and morphological changes in the vessel wall by unknown mechanisms. Locally produced substances may have a role in mediating these vascular changes. We have studied the expression of platelet-derived growth factor (PDGF) B chain and PDGF A chain, insulin-like growth factor (IGF)-I and IGF-II, endothelial cell growth factor (ECGF), basic fibroblast growth factor (bFGF), and transforming growth factor-beta (TGF-beta) in aortic tissue from normotensive rats and rats made hypertensive by deoxycorticosterone (DOC)/salt treatment. Using Northern blotting, we found that genes for each of these growth factors were transcriptionally active in the aorta of both normotensive and hypertensive rats. TGF-beta aortic mRNA levels increased up to threefold as a result of DOC/salt hypertension. In contrast, no major changes in the expression of either PDGF chain, IGF-I or II, ECGF, or bFGF were detectable. The results indicate that at least seven genes coding for growth factors that were shown previously to influence growth and function of vascular cells in vitro, are expressed in rat aorta in vivo. These findings support the hypothesis that synthesis and release of growth factors in the arterial wall are involved in autocrine and/or paracrine regulatory mechanisms. In addition, the increased expression of TGF-beta in vivo may have a role in mediating the aortic changes induced by hypertension.
R Sarzani, P Brecher, A V Chobanian
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American Journal of Hypertension | 2017 |
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H Zempo, J Suzuki, M Ogawa, R Watanabe, K Fujiu, I Manabe, SJ Conway, Y Taniyama, R Morishita, Y Hirata, M Isobe, R Nagai |
Hypertension Research | 2016 |
Impairment of arterial elastic properties and elevated circulating levels of transforming growth factor-beta in subjects with repaired coarctation of aorta
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International Journal for Numerical Methods in Biomedical Engineering | 2015 |
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Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2015 |
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American journal of physiology. Renal physiology | 2014 |
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Hypertension | 2010 |
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'Correction:' Serum transforming growth factor beta-1 (TGF-beta-1) levels in diabetic patients are not associated with pre-existent coronary artery disease
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Cardiovascular Diabetology | 2007 |
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The association of plasma adiponectin level with carotid arterial stiffness
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Proceedings of the National Academy of Sciences | 2000 |
TGF-βs and TGF-β receptors in atherosclerosis
TA McCaffrey |
Cytokine & Growth Factor Reviews | 2000 |
Transforming growth factor- 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage
M Suthanthiran, B Li, JO Song, R Ding, VK Sharma, JE Schwartz, P August |
Proceedings of the National Academy of Sciences | 2000 |
Ribozyme Oligonucleotides Against Transforming Growth Factor-β Inhibited Neointimal Formation After Vascular Injury in Rat Model: Potential Application of Ribozyme Strategy to Treat Cardiovascular Disease
K Yamamoto, R Morishita, N Tomita, T Shimozato, H Nakagami, A Kikuchi, M Aoki, J Higaki, Y Kaneda, T Ogihara |
Circulation | 2000 |
Mechanical Strain–Induced Extracellular Matrix Production by Human Vascular Smooth Muscle Cells: Role of TGF-β 1
CJ OCallaghan, B Williams |
Hypertension | 2000 |
Aging and Chronic Hypertension Decrease Expression of Rat Aortic Soluble Guanylyl Cyclase
S Klöß, A Bouloumié, A Mülsch |
Hypertension | 2000 |
Transforming Growth Factor β in Hypertensives With Cardiorenal Damage
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Hypertension | 2000 |
Recommended therapies for restenosis
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Expert Opinion on Therapeutic Patents | 1999 |
Does transforming growth factor β1 play a role in the pathogenesis of chronic allograft rejection?
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American journal of physiology. Heart and circulatory physiology | 1999 |
TGF-β 1 DNA Polymorphisms, Protein Levels, and Blood Pressure
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Hypertension | 1999 |
Prevention of Neointimal Formation by a Serine Protease Inhibitor, FUT-175, After Carotid Balloon Injury in Rats
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Stroke; a journal of cerebral circulation | 1999 |
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Proceedings of the National Academy of Sciences | 1998 |
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Journal of the American College of Cardiology | 1998 |
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European Journal of Pharmacology | 1998 |
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Overexpression of transforming growth factor 1 in arterial endothelium causes hyperplasia, apoptosis, and cartilaginous metaplasia
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Proceedings of the National Academy of Sciences | 1998 |
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American journal of physiology. Heart and circulatory physiology | 1998 |
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Negative Regulation of Local Hepatocyte Growth Factor Expression by Angiotensin II and Transforming Growth Factor-β in Blood Vessels: Potential Role of HGF in Cardiovascular Disease
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Hypertension | 1998 |
Vascular hypertrophy in experimental diabetes. Role of advanced glycation end products
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Kidney International | 1997 |
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Journal of Laboratory and Clinical Medicine | 1997 |
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Hypertension | 1997 |
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Hypertension | 1997 |
Bimodal Effects of Angiotensin II on Migration of Human and Rat Smooth Muscle Cells: Direct Stimulation and Indirect Inhibition Via Transforming Growth Factor-β1
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Arteriosclerosis, thrombosis, and vascular biology | 1997 |
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Life Sciences | 1996 |
REGULATION AND INTERACTIONS OF TRANSFORMING GROWTH FACTOR-? WITH CARDIOVASCULAR CELLS: IMPLICATIONS FOR DEVELOPMENT AND DISEASE
J Saltis, A Agrotis, A Bobik |
Clinical and Experimental Pharmacology and Physiology | 1996 |
VASCULAR REMODELLING AND MOLECULAR BIOLOGY: NEW CONCEPTS AND THERAPEUTIC POSSIBILITIES
A Agrotis, A Bobik |
Clinical and Experimental Pharmacology and Physiology | 1996 |
Postnatal regulation of fibroblast growth factor ligand and receptor gene expression in rat thoracic aorta
JA Winkles, GF Alberts, KA Peifley, K Nomoto, G Liau, MW Majesky |
The American Journal of Pathology | 1996 |
ELEVATED EPIDERMAL GROWTH FACTOR RECEPTOR LEVELS IN HYPERTENSIVE LYON RAT KIDNEY AND AORTA
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Clinical and Experimental Pharmacology and Physiology | 1996 |
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A Vascular Modulator, Hepatocyte Growth Factor, Is Associated With Systolic Pressure
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Hypertension | 1996 |
Endocrinology of the Vasculature
JR Sowers |
1996 | |
Dynamics of vascular remodeling: An overview and bibliography
SM Bortman, DW Losordo |
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Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta1
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Diabetes Mellitus and Hypertension, Emerging Therapeutic Perspectives
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SUPPRESSION OF VASCULAR TRANSFORMING GROWTH FACTOR-?1AND EXTRACELLULAR MATRIX GENE EXPRESSIONS BY CILAZAPRIL AND NIFEDIPINE IN HYPERTENSIVE RATS
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Clinical and Experimental Pharmacology and Physiology | 1995 |
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Hypertension | 1995 |
Multiple Risk Factors in Cardiovascular Disease
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1995 | |
Endothelin: Potential Role in Hypertension and Vascular Hypertrophy
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Hypertension | 1995 |
Molecular Regulation of the Bovine Endothelial Cell Nitric Oxide Synthase by Transforming Growth Factor–β 1
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EFFECT OF TRANSFORMING GROWTH FACTOR-?1 ON PLATELET-DERIVED GROWTH FACTOR RECEPTOR BINDING AND GENE EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS FROM SHR AND WKY RATS
A Agrotis, J Saltis, A Bobik |
Clinical and Experimental Pharmacology and Physiology | 1994 |
The basis of molecular strategies for treating coronary restenosis after angioplasty
SE Epstein, E Speir, EF Unger, RJ Guzman, T Finkel |
Journal of the American College of Cardiology | 1994 |
Preexisting Vascular Pathology in Donor and Recipient Vessels During Penile Microvascular Arterial Bypass Surgery
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New perspectives in hypertension research. Potentials of vascular biology
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Role of angiotensin II in renal injury of deoxycorticosterone acetate-salt hypertensive rats
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Hypertension increases insulin-like growth factor binding protein-4 mRNA levels in rat aorta
A Anwar, P Delafontaine |
Hypertension | 1994 |
Na(+)-H+ exchanger expression in vascular smooth muscle of spontaneously hypertensive and Wistar-Kyoto rats
PA Lucchesi, N DeRoux, BC Berk |
Hypertension | 1994 |
Hyperplastic growth of aortic smooth muscle cells in renovascular hypertensive rabbits is characterized by the expansion of an immature cell phenotype
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Journal of Clinical Investigation | 1993 |
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JM Davidson, O Zoia, JM Liu |
Journal of Cellular Physiology | 1993 |
Angiogenic role of endogenous basic fibroblast growth factor released by rat aorta after injury
S Villaschi, RF Nicosia |
The American Journal of Pathology | 1993 |
Sequestration and secretion of insulin-like growth factor-I by bovine aortic endothelial cells
CM Gajdusek, Z Luo, MR Mayberg |
Journal of Cellular Physiology | 1993 |
Procollagen Types I and III and Transforming Growth Factor-Beta Gene Expression in the Arterial Wall after Exposure to Periarterial Blood
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Chronic transplant rejection: Magnitude of the problem and pathogenetic mechanisms
LC Paul, H Benediktsson |
Transplantation Reviews | 1993 |
Expression of follistatin, an activin-binding protein, in vascular smooth muscle cells and arteriosclerotic lesions
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Arteriosclerosis Thrombosis and Vascular Biology | 1993 |
Vascular biology and medicine in the 1990s: scope, concepts, potentials, and perspectives
VJ Dzau, GH Gibbons, JP Cooke, N Omoigui |
Circulation | 1993 |
Cyclic AMP suppresses fibronectin expression in the rabbit aorta in vitro
WD Coats, P Brecher |
Arteriosclerosis Thrombosis and Vascular Biology | 1993 |
Arterial smooth muscle cell phenotype in stroke-prone spontaneously hypertensive rats
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Hypertension | 1993 |
Abdominal coarctation increases insulin-like growth factor I mRNA levels in rat aorta
KA Fath, RW Alexander, P Delafontaine |
Circulation research | 1993 |
Smooth muscle cell immediate-early gene and growth factor activation follows vascular injury. A putative in vivo mechanism for autocrine growth
JM Miano, N Vlasic, RR Tota, MB Stemerman |
Arteriosclerosis Thrombosis and Vascular Biology | 1993 |
Influence of the status of the renin-angiotensin system on the effect of cilazapril on neointima formation after vascular injury in rats
JP Clozel, RK Müller, S Roux, W Fischli, HR Baumgartner |
Circulation | 1993 |
Basic fibroblast growth factor in the extracellular matrix suppresses collagen synthesis and type III procollagen mRNA levels in arterial smooth muscle cell cultures
A Majors, LA Ehrhart |
Arteriosclerosis Thrombosis and Vascular Biology | 1993 |
Growth Factors and the Cardiovascular System
P Cummins |
1993 | |
Angiotensin und Herz
H Grobecker, G Heusch, BE Strauer |
1993 | |
Recent Progress in Atherosclerosis Research
A Roessner, E Vollmer |
1993 | |
Angiotensin and the Heart
H Grobecker, G Heusch, BE Strauer |
1993 | |
Fibronectin expression in the normal and hypertrophic rat heart
WS Mamuya, P Brecher |
Journal of Clinical Investigation | 1992 |
Transforming growth factor-beta 1 is decreased in remodeling hypertensive bovine pulmonary arteries
MD Botney, WC Parks, EC Crouch, K Stenmark, RP Mecham |
Journal of Clinical Investigation | 1992 |
Transforming growth factor-beta in disease: the dark side of tissue repair
WA Border, E Ruoslahti |
Journal of Clinical Investigation | 1992 |
Pathologic Hypertrophy with Fibrosis: The Structural Basis for Myocardial Failure
KT Weber, CG Brilla, SE Campbell, G Zhou, L Matsubara, E Guarda |
Blood Pressure | 1992 |
Arterial response to mechanical injury: balloon catheter de-endothelialization
GA Ferns, AL Stewart-Lee, EE Anggard |
Atherosclerosis | 1992 |
DIFFERENTIAL REGULATION BY TRANSFORMING GROWTH FACTOR-?1 OF PLATELET-DERIVED GROWTH FACTOR- STIMULATED PROLIFERATION OF VASCULAR SMOOTH MUSCLE CELLS FROM SHR AND WKY RATS
J Saltis, A Agrotis, A Bobik |
Clinical and Experimental Pharmacology and Physiology | 1992 |
Large-vessel endothelium switches to a microvascular phenotype during angiogenesis in collagen gel culture of rat aorta
RF Nicosia, E Bonanno, S Villaschi |
Atherosclerosis | 1992 |
Increased EGF binding and EGFR mRNA expression in rat aorta with chronic administration of pressor angiotensin II
MP Sambhi, N Swaminathan, H Wang, H Rong |
Biochemical Medicine and Metabolic Biology | 1992 |
Vascular effects of systemic hypertension
AV Chobanian |
The American Journal of Cardiology | 1992 |
Pathophysiology of atherosclerosis
AV Chobanian |
The American Journal of Cardiology | 1992 |
TGF-beta 1 potentiates growth factor-stimulated proliferation of vascular smooth muscle cells in genetic hypertension
J Saltis, A Agrotis, A Bobik |
American journal of physiology. Cell physiology | 1992 |
Local renin-angiotensin system in human adrenals and aldosteronomas
R Sarzani, F Fallo, P Dessì-Fulgheri, M Pistorello, A Lanari, VM Paci, F Mantero, A Rappelli |
Hypertension | 1992 |
Inhibition of smooth muscle cell proliferation by an antisense oligodeoxynucleotide targeting the messenger RNA encoding proliferating cell nuclear antigen
E Speir, SE Epstein |
Circulation | 1992 |
In vitro effects of a recombinant toxin targeted to the fibroblast growth factor receptor on rat vascular smooth muscle and endothelial cells
S Biro, CB Siegall, YM Fu, E Speir, I Pastan, SE Epstein |
Circulation research | 1992 |
Rat carotid neointimal smooth muscle cells reexpress a developmentally regulated mRNA phenotype during repair of arterial injury
MW Majesky, CM Giachelli, MA Reidy, SM Schwartz |
Circulation research | 1992 |
High potassium diets greatly increase growth-inhibiting agents in aortas of hypertensive rats
K Sugimoto, L Tobian, T Ishimitsu, JM Lange |
Hypertension | 1992 |
Production of transforming growth factor beta 1 during repair of arterial injury
MW Majesky, V Lindner, DR Twardzik, SM Schwartz, MA Reidy |
Journal of Clinical Investigation | 1991 |
Fibronectin biosynthesis in the rat aorta in vitro. Changes due to experimental hypertension
R Saouaf, I Takasaki, E Eastman, AV Chobanian, P Brecher |
Journal of Clinical Investigation | 1991 |
Culture-induced increase in acidic and basic fibroblast growth factor activities and their association with the nuclei of vascular endothelial and smooth muscle cells
E Speir, J Sasse, S Shrivastav, W Casscells |
Journal of Cellular Physiology | 1991 |
Interleukin 1 regulates heparin-binding growth factor 2 gene expression in vascular smooth muscle cells
CG Gay, JA Winkles |
Proceedings of the National Academy of Sciences | 1991 |
Expression of transforming growth factor-beta 1, -beta 2, and -beta 3 mRNA and protein in the murine lung
RW Pelton, MD Johnson, EA Perkett, LI Gold, HL Moses |
American journal of respiratory cell and molecular biology | 1991 |
Southwestern Internal Medicine Conference: Hormonal and Local Factors in Hypertension
NM Kaplan |
The American Journal of the Medical Sciences | 1991 |
Insulin-like growth factor I gene expression in vascular cells
P Delafontaine, KE Bernstein, RW Alexander |
Hypertension | 1991 |
Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells
SE Epstein, CB Siegall, S Biro, YM Fu, D FitzGerald, I Pastan |
Circulation | 1991 |
Hypertension-induced changes of platelet-derived growth factor receptor expression in rat aorta and heart
R Sarzani, G Arnaldi, AV Chobanian |
Hypertension | 1991 |
Polyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension
EE Soltis, PS Newman, JW Olson |
Hypertension | 1991 |
Biosynthesis of fibronectin by rabbit aorta
I Takasaki, AV Chobanian, P Brecher |
The Journal of biological chemistry | 1991 |
Transforming growth factor-beta activity in sheep lung lymph during the development of pulmonary hypertension
EA Perkett, RM Lyons, HL Moses, KL Brigham, B Meyrick |
Journal of Clinical Investigation | 1990 |
PDGF ligand and receptor gene expression during repair of arterial injury
MW Majesky, MA Reidy, DF Bowen-Pope, CE Hart, JN Wilcox, SM Schwartz |
The Journal of Cell Biology | 1990 |
Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function
AW Hahn, TJ Resink, T Scott-Burden, J Powell, Y Dohi, FR Bühler |
Cell regulation | 1990 |
Early proto-oncogene expression in rat aortic smooth muscle cells following endothelial removal
JM Miano, RR Tota, N Vlasic, KJ Danishefsky, MB Stemerman |
The American Journal of Pathology | 1990 |
Specific growth stimulation of cultured smooth muscle cells from spontaneously hypertensive rats by platelet-derived growth factor A-chain homodimer
TJ Resink, T Scott-Burden, AW Hahn, M Rouge, M Hosang, JS Powell, FR Bühler |
Cell regulation | 1990 |
Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-beta
RA Majack, MW Majesky, LV Goodman |
The Journal of Cell Biology | 1990 |
The effects of ACE inhibitors and other antihypertensive drugs on cardiovascular risk factors and atherogenesis
AV Chobanian |
Clinical Cardiology | 1990 |
Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit
AV Chobanian, CC Haudenschild, C Nickerson, R Drago |
Hypertension | 1990 |
Regulation of differentiated properties and proliferation of arterial smooth muscle cells
J Thyberg, U Hedin, M Sjölund, L Palmberg, BA Bottger |
Arteriosclerosis (Dallas, Tex.) | 1990 |
Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation
B Cercek, MC Fishbein, JS Forrester, RH Helfant, JA Fagin |
Circulation research | 1990 |
1989 Corcoran lecture: adaptive and maladaptive responses of the arterial wall to hypertension
AV Chobanian |
Hypertension | 1990 |
Cardiac myocytes as targets for the action of peptide growth factors
MD Schneider, TG Parker |
Circulation | 1990 |
Effect of hypertension on fibronectin expression in the rat aorta
I Takasaki, AV Chobanian, R Sarzani, P Brecher |
The Journal of biological chemistry | 1990 |