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Citations to this article

Growth factor expression in aorta of normotensive and hypertensive rats.
R Sarzani, … , P Brecher, A V Chobanian
R Sarzani, … , P Brecher, A V Chobanian
Published April 1, 1989
Citation Information: J Clin Invest. 1989;83(4):1404-1408. https://doi.org/10.1172/JCI114029.
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Research Article

Growth factor expression in aorta of normotensive and hypertensive rats.

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Abstract

Hypertension causes biochemical and morphological changes in the vessel wall by unknown mechanisms. Locally produced substances may have a role in mediating these vascular changes. We have studied the expression of platelet-derived growth factor (PDGF) B chain and PDGF A chain, insulin-like growth factor (IGF)-I and IGF-II, endothelial cell growth factor (ECGF), basic fibroblast growth factor (bFGF), and transforming growth factor-beta (TGF-beta) in aortic tissue from normotensive rats and rats made hypertensive by deoxycorticosterone (DOC)/salt treatment. Using Northern blotting, we found that genes for each of these growth factors were transcriptionally active in the aorta of both normotensive and hypertensive rats. TGF-beta aortic mRNA levels increased up to threefold as a result of DOC/salt hypertension. In contrast, no major changes in the expression of either PDGF chain, IGF-I or II, ECGF, or bFGF were detectable. The results indicate that at least seven genes coding for growth factors that were shown previously to influence growth and function of vascular cells in vitro, are expressed in rat aorta in vivo. These findings support the hypothesis that synthesis and release of growth factors in the arterial wall are involved in autocrine and/or paracrine regulatory mechanisms. In addition, the increased expression of TGF-beta in vivo may have a role in mediating the aortic changes induced by hypertension.

Authors

R Sarzani, P Brecher, A V Chobanian

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Journal of Clinical Investigation 1992
Transforming growth factor-beta 1 is decreased in remodeling hypertensive bovine pulmonary arteries
MD Botney, WC Parks, EC Crouch, K Stenmark, RP Mecham
Journal of Clinical Investigation 1992
Transforming growth factor-beta in disease: the dark side of tissue repair
WA Border, E Ruoslahti
Journal of Clinical Investigation 1992
Pathologic Hypertrophy with Fibrosis: The Structural Basis for Myocardial Failure
KT Weber, CG Brilla, SE Campbell, G Zhou, L Matsubara, E Guarda
Blood Pressure 1992
Arterial response to mechanical injury: balloon catheter de-endothelialization
GA Ferns, AL Stewart-Lee, EE Anggard
Atherosclerosis 1992
DIFFERENTIAL REGULATION BY TRANSFORMING GROWTH FACTOR-?1 OF PLATELET-DERIVED GROWTH FACTOR- STIMULATED PROLIFERATION OF VASCULAR SMOOTH MUSCLE CELLS FROM SHR AND WKY RATS
J Saltis, A Agrotis, A Bobik
Clinical and Experimental Pharmacology and Physiology 1992
Large-vessel endothelium switches to a microvascular phenotype during angiogenesis in collagen gel culture of rat aorta
RF Nicosia, E Bonanno, S Villaschi
Atherosclerosis 1992
Increased EGF binding and EGFR mRNA expression in rat aorta with chronic administration of pressor angiotensin II
MP Sambhi, N Swaminathan, H Wang, H Rong
Biochemical Medicine and Metabolic Biology 1992
Vascular effects of systemic hypertension
AV Chobanian
The American Journal of Cardiology 1992
Pathophysiology of atherosclerosis
AV Chobanian
The American Journal of Cardiology 1992
TGF-beta 1 potentiates growth factor-stimulated proliferation of vascular smooth muscle cells in genetic hypertension
J Saltis, A Agrotis, A Bobik
American journal of physiology. Cell physiology 1992
Local renin-angiotensin system in human adrenals and aldosteronomas
R Sarzani, F Fallo, P Dessì-Fulgheri, M Pistorello, A Lanari, VM Paci, F Mantero, A Rappelli
Hypertension 1992
Inhibition of smooth muscle cell proliferation by an antisense oligodeoxynucleotide targeting the messenger RNA encoding proliferating cell nuclear antigen
E Speir, SE Epstein
Circulation 1992
In vitro effects of a recombinant toxin targeted to the fibroblast growth factor receptor on rat vascular smooth muscle and endothelial cells
S Biro, CB Siegall, YM Fu, E Speir, I Pastan, SE Epstein
Circulation research 1992
Rat carotid neointimal smooth muscle cells reexpress a developmentally regulated mRNA phenotype during repair of arterial injury
MW Majesky, CM Giachelli, MA Reidy, SM Schwartz
Circulation research 1992
High potassium diets greatly increase growth-inhibiting agents in aortas of hypertensive rats
K Sugimoto, L Tobian, T Ishimitsu, JM Lange
Hypertension 1992
Production of transforming growth factor beta 1 during repair of arterial injury
MW Majesky, V Lindner, DR Twardzik, SM Schwartz, MA Reidy
Journal of Clinical Investigation 1991
Fibronectin biosynthesis in the rat aorta in vitro. Changes due to experimental hypertension
R Saouaf, I Takasaki, E Eastman, AV Chobanian, P Brecher
Journal of Clinical Investigation 1991
Culture-induced increase in acidic and basic fibroblast growth factor activities and their association with the nuclei of vascular endothelial and smooth muscle cells
E Speir, J Sasse, S Shrivastav, W Casscells
Journal of Cellular Physiology 1991
Interleukin 1 regulates heparin-binding growth factor 2 gene expression in vascular smooth muscle cells
CG Gay, JA Winkles
Proceedings of the National Academy of Sciences 1991
Expression of transforming growth factor-beta 1, -beta 2, and -beta 3 mRNA and protein in the murine lung
RW Pelton, MD Johnson, EA Perkett, LI Gold, HL Moses
American journal of respiratory cell and molecular biology 1991
Southwestern Internal Medicine Conference: Hormonal and Local Factors in Hypertension
NM Kaplan
The American Journal of the Medical Sciences 1991
Insulin-like growth factor I gene expression in vascular cells
P Delafontaine, KE Bernstein, RW Alexander
Hypertension 1991
Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells
SE Epstein, CB Siegall, S Biro, YM Fu, D FitzGerald, I Pastan
Circulation 1991
Hypertension-induced changes of platelet-derived growth factor receptor expression in rat aorta and heart
R Sarzani, G Arnaldi, AV Chobanian
Hypertension 1991
Polyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension
EE Soltis, PS Newman, JW Olson
Hypertension 1991
Biosynthesis of fibronectin by rabbit aorta
I Takasaki, AV Chobanian, P Brecher
The Journal of biological chemistry 1991
Transforming growth factor-beta activity in sheep lung lymph during the development of pulmonary hypertension
EA Perkett, RM Lyons, HL Moses, KL Brigham, B Meyrick
Journal of Clinical Investigation 1990
PDGF ligand and receptor gene expression during repair of arterial injury
MW Majesky, MA Reidy, DF Bowen-Pope, CE Hart, JN Wilcox, SM Schwartz
The Journal of Cell Biology 1990
Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function
AW Hahn, TJ Resink, T Scott-Burden, J Powell, Y Dohi, FR Bühler
Cell regulation 1990
Early proto-oncogene expression in rat aortic smooth muscle cells following endothelial removal
JM Miano, RR Tota, N Vlasic, KJ Danishefsky, MB Stemerman
The American Journal of Pathology 1990
Specific growth stimulation of cultured smooth muscle cells from spontaneously hypertensive rats by platelet-derived growth factor A-chain homodimer
TJ Resink, T Scott-Burden, AW Hahn, M Rouge, M Hosang, JS Powell, FR Bühler
Cell regulation 1990
Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-beta
RA Majack, MW Majesky, LV Goodman
The Journal of Cell Biology 1990
The effects of ACE inhibitors and other antihypertensive drugs on cardiovascular risk factors and atherogenesis
AV Chobanian
Clinical Cardiology 1990
Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit
AV Chobanian, CC Haudenschild, C Nickerson, R Drago
Hypertension 1990
Regulation of differentiated properties and proliferation of arterial smooth muscle cells
J Thyberg, U Hedin, M Sjölund, L Palmberg, BA Bottger
Arteriosclerosis (Dallas, Tex.) 1990
Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation
B Cercek, MC Fishbein, JS Forrester, RH Helfant, JA Fagin
Circulation research 1990
1989 Corcoran lecture: adaptive and maladaptive responses of the arterial wall to hypertension
AV Chobanian
Hypertension 1990
Cardiac myocytes as targets for the action of peptide growth factors
MD Schneider, TG Parker
Circulation 1990
Effect of hypertension on fibronectin expression in the rat aorta
I Takasaki, AV Chobanian, R Sarzani, P Brecher
The Journal of biological chemistry 1990

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