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Citations to this article

Predominant expression of circulating CD3+ lymphocytes bearing gamma T cell receptor in a prolonged immunodeficiency after allogeneic bone marrow transplantation.
E Vilmer, … , M Boiron, A Bensussan
E Vilmer, … , M Boiron, A Bensussan
Published September 1, 1988
Citation Information: J Clin Invest. 1988;82(3):755-761. https://doi.org/10.1172/JCI113675.
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Research Article

Predominant expression of circulating CD3+ lymphocytes bearing gamma T cell receptor in a prolonged immunodeficiency after allogeneic bone marrow transplantation.

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Abstract

The cell surface expression of alpha:beta heterodimer was studied using WT31 monoclonal antibody, in peripheral blood lymphocytes (PBL) from a patient who developed a prolonged immunodeficiency after allogeneic bone marrow transplantation. This patient, grafted for chronic myelogenous leukemia, received T cell depleted bone marrow from her HLA, A, B, D matched sibling. The late occurrence of opportunistic infection, led us to analyze the phenotype of patient PBL. 70% of PBL were CD3+ and 29% WT31+, indicating that the majority of CD3+ PBL did not express the alpha:beta heterodimer. Transcription of the genes encoding the alpha, beta, and gamma chains was assessed in cell lines derived from PBL, by Northern blot analysis. We showed that the CD3+ WT31- subset expressed a truncated, beta mRNA (1.0 kb) and also truncated alpha transcript (1.4 kb). To determine the CD3-associated structure on CD3+ WT31- cell line, immunoprecipitation assays were performed using monoclonal anti-CD3 and an hetero antiserum against gamma peptides. These CD3+ WT31- cells expressed a disulfide linked dimer, composed of products of gamma gene (37 kD, 40 kD) and of undefined delta chain (45 kD). Functional analyses were performed in PBL before and after sorting with WT31 and anti-CD3 antibody. These circulating CD3+ WT31- cells were unable to proliferate when triggered with anti-T3 beads and they seemed to mediate a suppressor activity on CD3+ WT31+ cells.

Authors

E Vilmer, P Guglielmi, V David, G Leca, C Rabian, L Degos, M Boiron, A Bensussan

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Total citations by year

Year: 2021 2004 2002 1999 1998 1997 1996 1994 1993 1992 1991 1990 1989 Total
Citations: 1 1 1 1 1 1 1 2 2 2 6 9 5 33
Citation information
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Citations to this article (33)

Title and authors Publication Year
γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends
M de Souza Barros, ND de Araújo, F Magalhães-Gama, TL Ribeiro, FS Hanna, AM Tarragô, A Malheiro, AG Costa
Frontiers in immunology 2021
Stem Cell Transplantation for Hematologic Malignancies
RJ Soiffer
2004
BY55/CD160 acts as a co‐receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression
M Nikolova, A MarieCardine, L Boumsell, A Bensussan
International Immunology 2002
Clinical Applications of Cytokines and Growth Factors
JR Wingard, GD Demetri
1999
Increase in Vdelta1+gammadelta T cells in the peripheral blood and bone marrow as a selective feature of HIV-1 but not other virus infections
R Rossol, JU Dobmeyer, TS Dobmeyer, SA Klein, S Rossol, D Wesch, D Hoelzer, D Kabelitz, EB Helm
British Journal of Haematology 1998
Bronchiolitis obliterans in ataxia-telangiectasia
M Ito, A Nakagawa, N Hirabayashi, J Asai
Virchows Archiv 1997
γδ T cells are secondary participants in acute graft-versus-host reactions initiated by CD4+ αβT cells
S Tsuji, D Char, RP Bucy, M Simonsen, CL Chen, MD Cooper
European Journal of Immunology 1996
Peripheral T cell receptors αβ and γδ in patients with Hodgkin's lymphoma
H Akan, M Beksaçl, I Aydoǧgdu, H Koçl, O Ilhan, M Özcan
British Journal of Haematology 1994
Increased Level of Circulating Gamma/Delta T Cells in a Patient With Eosinophilic Granuloma
N Shijubo, K Shigehara, S Tsutahara, S Abe
Chest 1994
Lysis of CD4+lymphocytes by non-HLA-restricted cytotoxic T lymphoe from HIV-infected individuals
MD Grant, FM Smaill, KL Rosenthal
Clinical & Experimental Immunology 1993
Lysis of CD4+ lymphocytes by non-HLA-restricted cytotoxic T lymphocytes from HIV-infected individuals
MD Grant, FM Smaill, KL Rosenthal
Clinical & Experimental Immunology 1993
Phenotypic profile and functional characteristics of human gamma and delta T cells during acute toxoplasmosis
PD Paoli, G Basaglia, D Gennari, M Crovatto, ML Modolo, G Santini
Journal of clinical microbiology 1992
Differential human immunodeficiency virus expression in CD4+ cloned lymphocytes: from viral latency to replication
A Chapel, A Bensussan, E Vilmer, D Dormont
Journal of virology 1992
Direct involvement of CD7 (gp40) in activation of TcRγ/δ+ T cells
S Carrel, S Salvi, F Rafti, M Favrot, C Rapin, RP Sekaly
European Journal of Immunology 1991
ELEVATED T CELL RECEPTOR γδ + T CELLS IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS
J Hassan, C Feighery, B Bresnihan, A Whelan
British Journal of Haematology 1991
Generation and Function of αδ T Cells after Allogeneic Bone Marrow Transplantation in Humans: Comparison in Absence or Presence of HLA-Matched or Mismatched Thymus
M Nagasawa, T Morio, S Takagi, J Yata
Pediatrics International 1991
Induction, Specificity and Elimination of Asialo-GM 1+ Graft-Versus-Host Effector Cells of Donor Origin
T Ghayur, A Xenocostas, TA Seemayer, WS Lapp
Scandinavian Journal of Immunology 1991
A subset of γδ lymphocytes is increased during HIV-1 infection
P Paoli, D Gennari, P Martelli, G Basaglia, M Crovatto, S Battistin, C Santini
Clinical & Experimental Immunology 1991
A subset of gamma delta lymphocytes is increased during HIV-1 infection
PD Paoli, D Gennari, P Martelli, G Basaglia, M Crovatto, S Battistin, G Santini
Clinical & Experimental Immunology 1991
Increased numbers of T lymphocytes with gamma delta-positive antigen receptors in a subgroup of individuals with pulmonary sarcoidosis
B Balbi, DR Moller, M Kirby, KJ Holroyd, RG Crystal
Journal of Clinical Investigation 1990
Immunodeficiency after Bone Marrow Transplantation can be associated with Autoreactive T-Cell Receptor gammaomega-bearing Lymphocytes
A Bensussan, V David, E Vilmer, G Leca, L Boxbisell
Immunological Reviews 1990
Long-term immunomodulatory effects of t lymphocyte depletion in patients with systemic sclerosis
JJ Goronzy, CM Weyand
Arthritis & Rheumatism 1990
Characterization of normal human CD3+ CD5- and γδ T cell receptor positive T lymphocytes
EF Srour, T Leemhuis, L Jenski, R Redmond, D Fillak, J Jansen
Clinical & Experimental Immunology 1990
Characterization of normal human CD3+ CD5- and gamma delta T cell receptor positive T lymphocytes
EF Spour, T Leemhuis, L Jenski, R Redmond, D Fillak, J Jansen
Clinical & Experimental Immunology 1990
Relative Increase of T Cells Expressing the Gamma/Delta Rather Than the Alpha/Beta Receptor in Ataxia-Telangiectasia
M Carbonari, M Cherchi, R Paganelli, G Giannini, E Galli, C Gaetano, C Papetti, M Fiorilli
New England Journal of Medicine 1990
Increased gamma delta T cells in acute Plasmodium falciparum malaria
M Ho, HK Webster, P Tongtawe, K Pattanapanyasat, WP Weidanz
Immunology Letters 1990
Detection of a T cell receptor δ chain with an anti-TCR α chain serum
G Leca, JC Bories, F Davi, A Bensussan
Clinical Immunology and Immunopathology 1990
Correlation between T cell receptor γδ isotypic forms and cytotoxic activity: Analysis with human T cell clones and lines
H Dastot, M Schmid, C Gontier, M Amiot, D Mathieu-Mahul, A Bensussan, L Boumsell
Cellular Immunology 1990
‘Fetal-type’ B and T lymphocytes in rheumatoid arthritis and primary Sjögren's syndrome
C Plater-Zyberk, FM Brennan, M Feldmann, RN Maini
Journal of Autoimmunity 1989
Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjögren's syndrome
F Brennan, C Plater-Zyberk, RN Maini, M Feldmann
Clinical & Experimental Immunology 1989
Immunoactive products of human placenta. II. Direct inhibition of non-MHC restricted cytolytic activity of human CD3 alpha-beta but not CD3 gamma-delta expressing T cell clones
E Menu, V David, A Bensussan, G Chaouat
Journal of Reproductive Immunology 1989
T–Cell Activation in Health and Disease
J Timsit, W Savino, C Boitard, JF Bach
T–Cell Activation in Health and Disease 1989
Immunobiology of HLA
B Dupont
1989

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